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1. Neuroradiological, genetic and clinical characteristics of histone H3 K27-mutant diffuse midline gliomas in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort

Author

Hayashi, Nobuhide, Fukai, Junya, Nakatogawa, Hirokazu, Kawaji, Hiroshi, Yoshioka, Ema, Kodama, Yoshinori, Nakajo, Kosuke, Uda, Takehiro, Naito, Kentaro, Kijima, Noriyuki, Okita, Yoshiko, Kagawa, Naoki, Takahashi, Yoshinobu, Hashimoto, Naoya, Arita, Hideyuki, Takano, Koji, Sakamoto, Daisuke, Iida, Tomoko, Arakawa, Yoshiki, Kawauchi, Takeshi, Sonoda, Yukihiko, Mitobe, Yuta, Ishibashi, Kenichi, Matsuda, Masahide, Achiha, Takamune, Tomita, Takahiro, Nonaka, Masahiro, Hara, Keijiro, Takebe, Noriyoshi, Tsuzuki, Takashi, Nakajima, Yoshikazu, Ohue, Shiro, Nakajima, Nobuyuki, Watanabe, Akira, Inoue, Akihiro, Umegaki, Masao, Kanematsu, Daisuke, Katsuma, Asako, Sumida, Miho, Shofuda, Tomoko, Mano, Masayuki, Kinoshita, Manabu, Mori, Kanji, Nakao, Naoyuki, and Kanemura, Yonehiro

Published
2024
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2. Failure of human rhombic lip differentiation underlies medulloblastoma formation

Author

Hendrikse, Liam D, Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H, Erickson, Anders W, Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L, Shokouhian, Mohammad, Suárez, Raúl A, Ly, Michelle, Borlase, Stephanie, Scott, David S, Vladoiu, Maria C, Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y, Kumar, Sachin A, Balin, Polina, Visvanathan, Abhirami, Lee, John JY, Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L, Luu, Betty, Bérubé, Pierre, Wang, Yu C, Pfister, Stefan M, Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A, Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim J, Kros, Johan M, Zitterbart, Karel, Bailey, Swneke D, Eberhart, Charles G, Rao, Amulya AN, Giannini, Caterina, Olson, James M, Garami, Miklós, Hauser, Peter, Phillips, Joanna J, Ra, Young S, de Torres, Carmen, Mora, Jaume, Li, Kay KW, Ng, Ho-Keung, Poon, Wai S, Pollack, Ian F, López-Aguilar, Enrique, Gillespie, G Yancey, Van Meter, Timothy E, Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C, Cooper, Michael K, Rubin, Joshua B, Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S, Van Meir, Erwin G, Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G, Faria, Claudia C, Roussel, Martine F, Boop, Frederick, Chan, Jennifer A, Aldinger, Kimberly A, Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E, and Thompson, Eric M

Subjects
Stem Cell Research, Brain Disorders, Neurosciences, Rare Diseases, Stem Cell Research - Nonembryonic - Non-Human, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Cell Differentiation, Cell Lineage, Cerebellar Neoplasms, Cerebellum, Core Binding Factor alpha Subunits, Hedgehog Proteins, Histone Demethylases, Humans, Ki-67 Antigen, Medulloblastoma, Metencephalon, Muscle Proteins, Mutation, Otx Transcription Factors, Repressor Proteins, T-Box Domain Proteins, Transcription Factors, General Science & Technology
Abstract

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1-4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5-8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES+KI67+ unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB.

Published
2022

3. Subtyping of Group 3/4 medulloblastoma as a potential prognostic biomarker among patients treated with reduced dose of craniospinal irradiation: a Japanese Pediatric Molecular Neuro-Oncology Group study

Author

Fukuoka, Kohei, Kurihara, Jun, Shofuda, Tomoko, Kagawa, Naoki, Yamasaki, Kai, Ando, Ryo, Ishida, Joji, Kanamori, Masayuki, Kawamura, Atsufumi, Park, Young-Soo, Kiyotani, Chikako, Akai, Takuya, Keino, Dai, Miyairi, Yosuke, Sasaki, Atsushi, Hirato, Junko, Inoue, Takeshi, Nakazawa, Atsuko, Koh, Katsuyoshi, Nishikawa, Ryo, Date, Isao, Nagane, Motoo, Ichimura, Koichi, and Kanemura, Yonehiro

Published
2023
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4. The transcriptional landscape of Shh medulloblastoma.

Author

Skowron, Patryk, Farooq, Hamza, Cavalli, Florence MG, Morrissy, A Sorana, Ly, Michelle, Hendrikse, Liam D, Wang, Evan Y, Djambazian, Haig, Zhu, Helen, Mungall, Karen L, Trinh, Quang M, Zheng, Tina, Dai, Shizhong, Stucklin, Ana S Guerreiro, Vladoiu, Maria C, Fong, Vernon, Holgado, Borja L, Nor, Carolina, Wu, Xiaochong, Abd-Rabbo, Diala, Bérubé, Pierre, Wang, Yu Chang, Luu, Betty, Suarez, Raul A, Rastan, Avesta, Gillmor, Aaron H, Lee, John JY, Zhang, Xiao Yun, Daniels, Craig, Dirks, Peter, Malkin, David, Bouffet, Eric, Tabori, Uri, Loukides, James, Doz, François P, Bourdeaut, Franck, Delattre, Olivier O, Masliah-Planchon, Julien, Ayrault, Olivier, Kim, Seung-Ki, Meyronet, David, Grajkowska, Wieslawa A, Carlotti, Carlos G, de Torres, Carmen, Mora, Jaume, Eberhart, Charles G, Van Meir, Erwin G, Kumabe, Toshihiro, French, Pim J, Kros, Johan M, Jabado, Nada, Lach, Boleslaw, Pollack, Ian F, Hamilton, Ronald L, Rao, Amulya A Nageswara, Giannini, Caterina, Olson, James M, Bognár, László, Klekner, Almos, Zitterbart, Karel, Phillips, Joanna J, Thompson, Reid C, Cooper, Michael K, Rubin, Joshua B, Liau, Linda M, Garami, Miklós, Hauser, Peter, Li, Kay Ka Wai, Ng, Ho-Keung, Poon, Wai Sang, Yancey Gillespie, G, Chan, Jennifer A, Jung, Shin, McLendon, Roger E, Thompson, Eric M, Zagzag, David, Vibhakar, Rajeev, Ra, Young Shin, Garre, Maria Luisa, Schüller, Ulrich, Shofuda, Tomoko, Faria, Claudia C, López-Aguilar, Enrique, Zadeh, Gelareh, Hui, Chi-Chung, Ramaswamy, Vijay, Bailey, Swneke D, Jones, Steven J, Mungall, Andrew J, Moore, Richard A, Calarco, John A, Stein, Lincoln D, Bader, Gary D, Reimand, Jüri, Ragoussis, Jiannis, Weiss, William A, Marra, Marco A, Suzuki, Hiromichi, and Taylor, Michael D

Subjects
Humans, Medulloblastoma, Cerebellar Neoplasms, Signal Transduction, Gene Expression Regulation, Neoplastic, Adolescent, Adult, Middle Aged, Child, Child, Preschool, Infant, Female, Male, Hedgehog Proteins, Gene Regulatory Networks, Genetic Variation, Young Adult, Transcriptome, Pediatric Research Initiative, Brain Cancer, Pediatric, Rare Diseases, Genetics, Pediatric Cancer, Clinical Research, Brain Disorders, Neurosciences, Biotechnology, Human Genome, Cancer, 2.1 Biological and endogenous factors
Abstract

Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated importance of non-coding RNA transcripts. We identify alterations within the cAMP dependent pathway (GNAS, PRKAR1A) which converge on GLI2 activity and show that 18% of tumors have a genetic event that directly targets the abundance and/or stability of MYCN. Furthermore, we discover an extensive network of fusions in focally amplified regions encompassing GLI2, and several loss-of-function fusions in tumor suppressor genes PTCH1, SUFU and NCOR1. Molecular convergence on a subset of genes by nucleotide variants, copy number aberrations, and gene fusions highlight the key roles of specific pathways in the pathogenesis of Sonic hedgehog medulloblastoma and open up opportunities for therapeutic intervention.

Published
2021

5. TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations.

Author

Arita, Hideyuki, Matsushita, Yuko, Machida, Ryunosuke, Yamasaki, Kai, Hata, Nobuhiro, Ohno, Makoto, Yamaguchi, Shigeru, Sasayama, Takashi, Tanaka, Shota, Higuchi, Fumi, Iuchi, Toshihiko, Saito, Kuniaki, Kanamori, Masayuki, Matsuda, Ken-Ichiro, Miyake, Yohei, Tamura, Kaoru, Tamai, Sho, Nakamura, Taishi, Uda, Takehiro, Okita, Yoshiko, Fukai, Junya, Sakamoto, Daisuke, Hattori, Yasuhiko, Pareira, Eriel, Hatae, Ryusuke, Ishi, Yukitomo, Miyakita, Yasuji, Tanaka, Kazuhiro, Takayanagi, Shunsaku, Otani, Ryohei, Sakaida, Tsukasa, Kobayashi, Keiichi, Saito, Ryuta, Kurozumi, Kazuhiko, Shofuda, Tomoko, Nonaka, Masahiro, Suzuki, Hiroyoshi, Shibuya, Makoto, Komori, Takashi, Sasaki, Hikaru, Mizoguchi, Masahiro, Kishima, Haruhiko, Nakada, Mitsutoshi, Sonoda, Yukihiko, Tominaga, Teiji, Nagane, Motoo, Nishikawa, Ryo, Kanemura, Yonehiro, Kuchiba, Aya, Narita, Yoshitaka, and Ichimura, Koichi

Subjects
1p/19q codeletion, CDKN2A, Glioma, IDH1/2, TERT, Adolescent, Adult, Aged, Aged, 80 and over, Astrocytoma, Brain Neoplasms, Chromosome Deletion, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 19, Female, Glioblastoma, Glioma, Humans, Isocitrate Dehydrogenase, Karnofsky Performance Status, Male, Middle Aged, Multivariate Analysis, Mutation, Neoplasm Grading, Neurosurgical Procedures, Oligodendroglioma, Prognosis, Promoter Regions, Genetic, Proportional Hazards Models, Radiotherapy, Adjuvant, Retrospective Studies, Survival Rate, Telomerase, Young Adult
Abstract

TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated gliomas. However, whether these mutations have an impact on patient survival independent of 1p/19q codeletion is unknown. In this study, we investigated the impact of TERT promoter mutations on survival in IDH-mutated glioma cases. Detailed clinical information and molecular status data were collected for a cohort of 560 adult patients with IDH-mutated gliomas. Among these patients, 279 had both TERT promoter mutation and 1p/19q codeletion, while 30 had either TERT promoter mutation (n = 24) or 1p/19q codeletion (n = 6) alone. A univariable Cox proportional hazard analysis for survival using clinical and genetic factors indicated that a Karnofsky performance status score (KPS) of 90 or 100, WHO grade II or III, TERT promoter mutation, 1p/19q codeletion, radiation therapy, and extent of resection (90-100%) were associated with favorable prognosis (p

Published
2020

6. Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains

Author

Kanemura, Yonehiro, primary, Yamamoto, Atsuyo, additional, Katsuma, Asako, additional, Fukusumi, Hayato, additional, Shofuda, Tomoko, additional, Kanematsu, Daisuke, additional, Handa, Yukako, additional, Sumida, Miho, additional, Yoshioka, Ema, additional, Mine, Yutaka, additional, Yamaguchi, Ryo, additional, Okada, Masayasu, additional, Igarashi, Michihiro, additional, Sekino, Yuko, additional, Shirao, Tomoaki, additional, Nakamura, Masaya, additional, and Okano, Hideyuki, additional

Published
2024
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8. Prediction of MGMT promotor methylation status in glioblastoma by contrast-enhanced T1-weighted intensity image

Author

Sanada, Takahiro, primary, Kinoshita, Manabu, additional, Sasaki, Takahiro, additional, Yamamoto, Shota, additional, Fujikawa, Seiya, additional, Fukuyama, Shusei, additional, Hayashi, Nobuhide, additional, Fukai, Junya, additional, Okita, Yoshiko, additional, Nonaka, Masahiro, additional, Uda, Takehiro, additional, Arita, Hideyuki, additional, Mori, Kanji, additional, Ishibashi, Kenichi, additional, Takano, Koji, additional, Nishida, Namiko, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanematsu, Daisuke, additional, Tanino, Mishie, additional, Kodama, Yoshinori, additional, Mano, Masayuki, additional, and Kanemura, Yonehiro, additional

Published
2024
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9. Intertumoral Heterogeneity within Medulloblastoma Subgroups

Author

Cavalli, Florence MG, Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David JH, Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M, Farooq, Hamza, Isaev, Keren, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Rao, Amulya A Nageswara, Li, Kay Ka Wai, Ng, Ho-Keung, Eberhart, Charles G, Pollack, Ian F, Hamilton, Ronald L, Gillespie, G Yancey, Olson, James M, Leary, Sarah, Weiss, William A, Lach, Boleslaw, Chambless, Lola B, Thompson, Reid C, Cooper, Michael K, Vibhakar, Rajeev, Hauser, Peter, van Veelen, Marie-Lise C, Kros, Johan M, French, Pim J, Ra, Young Shin, Kumabe, Toshihiro, López-Aguilar, Enrique, Zitterbart, Karel, Sterba, Jaroslav, Finocchiaro, Gaetano, Massimino, Maura, Van Meir, Erwin G, Osuka, Satoru, Shofuda, Tomoko, Klekner, Almos, Zollo, Massimo, Leonard, Jeffrey R, Rubin, Joshua B, Jabado, Nada, Albrecht, Steffen, Mora, Jaume, Van Meter, Timothy E, Jung, Shin, Moore, Andrew S, Hallahan, Andrew R, Chan, Jennifer A, Tirapelli, Daniela PC, Carlotti, Carlos G, Fouladi, Maryam, Pimentel, José, Faria, Claudia C, Saad, Ali G, Massimi, Luca, Liau, Linda M, Wheeler, Helen, Nakamura, Hideo, Elbabaa, Samer K, Perezpeña-Diazconti, Mario, de León, Fernando Chico Ponce, Robinson, Shenandoah, Zapotocky, Michal, Lassaletta, Alvaro, Huang, Annie, Hawkins, Cynthia E, Tabori, Uri, Bouffet, Eric, Bartels, Ute, Dirks, Peter B, Rutka, James T, Bader, Gary D, Reimand, Jüri, Goldenberg, Anna, Ramaswamy, Vijay, and Taylor, Michael D

Subjects
Genetics, Rare Diseases, Pediatric Cancer, Cancer, Brain Cancer, Pediatric Research Initiative, Pediatric, Human Genome, Brain Disorders, Cluster Analysis, Cohort Studies, DNA Copy Number Variations, DNA Methylation, Gene Expression Profiling, Genomics, Humans, Medulloblastoma, Precision Medicine, copy number, gene expression, integrative clustering, medulloblastoma, methylation, subgroups, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.

Published
2017

10. Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation

Author

Hendrikse, Liam D., Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H., Erickson, Anders W., Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L., Shokouhian, Mohammad, Suárez, Raúl A., Ly, Michelle, Borlase, Stephanie, Scott, David S., Vladoiu, Maria C., Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J. Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y., Kumar, Sachin A., Balin, Polina, Visvanathan, Abhirami, Lee, John J. Y., Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L., Luu, Betty, Bérubé, Pierre, Wang, Yu C., Pfister, Stefan M., Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A., Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim J., Kros, Johan M., Zitterbart, Karel, Bailey, Swneke D., Eberhart, Charles G., Rao, Amulya A. N., Giannini, Caterina, Olson, James M., Garami, Miklós, Hauser, Peter, Phillips, Joanna J., Ra, Young S., de Torres, Carmen, Mora, Jaume, Li, Kay K. W., Ng, Ho-Keung, Poon, Wai S., Pollack, Ian F., López-Aguilar, Enrique, Gillespie, G. Yancey, Van Meter, Timothy E., Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C., Cooper, Michael K., Rubin, Joshua B., Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S., Van Meir, Erwin G., Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G., Faria, Claudia C., Roussel, Martine F., Boop, Frederick, Chan, Jennifer A., Aldinger, Kimberly A., Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E., Thompson, Eric M., Ansari, Marc, Garre, Maria L., Chico, Fernando, Eguía, Pilar, Pérezpeña, Mario, Morrissy, A. Sorana, Cavalli, Florence M. G., Wu, Xiaochong, Daniels, Craig, Rich, Jeremy N., Jones, Steven J. M., Moore, Richard A., Marra, Marco A., Huang, Xi, Reimand, Jüri, Sorensen, Poul H., Wechsler-Reya, Robert J., Weiss, William A., Pugh, Trevor J., Garzia, Livia, Kleinman, Claudia L., Stein, Lincoln D., Jabado, Nada, Malkin, David, Ayrault, Olivier, Golden, Jeffrey A., Ellison, David W., Doble, Brad, Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E., Suzuki, Hiromichi, Millen, Kathleen J., and Taylor, Michael D.

Published
2022
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11. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Author

Thompson, Eric M, Hielscher, Thomas, Bouffet, Eric, Remke, Marc, Luu, Betty, Gururangan, Sridharan, McLendon, Roger E, Bigner, Darell D, Lipp, Eric S, Perreault, Sebastien, Cho, Yoon-Jae, Grant, Gerald, Kim, Seung-Ki, Lee, Ji Yeoun, Rao, Amulya A Nageswara, Giannini, Caterina, Li, Kay Ka Wai, Ng, Ho-Keung, Yao, Yu, Kumabe, Toshihiro, Tominaga, Teiji, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Low, David CY, Seow, Wan Tew, Chang, Kenneth TE, Mora, Jaume, Pollack, Ian F, Hamilton, Ronald L, Leary, Sarah, Moore, Andrew S, Ingram, Wendy J, Hallahan, Andrew R, Jouvet, Anne, Fèvre-Montange, Michelle, Vasiljevic, Alexandre, Faure-Conter, Cecile, Shofuda, Tomoko, Kagawa, Naoki, Hashimoto, Naoya, Jabado, Nada, Weil, Alexander G, Gayden, Tenzin, Wataya, Takafumi, Shalaby, Tarek, Grotzer, Michael, Zitterbart, Karel, Sterba, Jaroslav, Kren, Leos, Hortobágyi, Tibor, Klekner, Almos, László, Bognár, Pócza, Tímea, Hauser, Peter, Schüller, Ulrich, Jung, Shin, Jang, Woo-Youl, French, Pim J, Kros, Johan M, van Veelen, Marie-Lise C, Massimi, Luca, Leonard, Jeffrey R, Rubin, Joshua B, Vibhakar, Rajeev, Chambless, Lola B, Cooper, Michael K, Thompson, Reid C, Faria, Claudia C, Carvalho, Alice, Nunes, Sofia, Pimentel, José, Fan, Xing, Muraszko, Karin M, López-Aguilar, Enrique, Lyden, David, Garzia, Livia, Shih, David JH, Kijima, Noriyuki, Schneider, Christian, Adamski, Jennifer, Northcott, Paul A, Kool, Marcel, Jones, David TW, Chan, Jennifer A, Nikolic, Ana, Garre, Maria Luisa, Van Meir, Erwin G, Osuka, Satoru, Olson, Jeffrey J, Jahangiri, Arman, Castro, Brandyn A, Gupta, Nalin, Weiss, William A, Moxon-Emre, Iska, Mabbott, Donald J, Lassaletta, Alvaro, Hawkins, Cynthia E, Tabori, Uri, Drake, James, and Kulkarni, Abhaya

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Oncology and Carcinogenesis, Brain Disorders, Rare Diseases, Brain Cancer, Pediatric Research Initiative, Pediatric, Cancer, Adult, Brain Neoplasms, Canada, Child, Child, Preschool, Combined Modality Therapy, Disease Progression, Disease-Free Survival, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Medulloblastoma, Prognosis, Retrospective Studies, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundPatients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner.MethodsWe retrospectively identified patients who had a histological diagnosis of medulloblastoma and complete data about extent of resection and survival from centres participating in the Medulloblastoma Advanced Genomics International Consortium. We collected from resections done between April, 1997, and February, 2013, at 35 international institutions. We established medulloblastoma subgroup affiliation by gene expression profiling on frozen or formalin-fixed paraffin-embedded tissues. We classified extent of resection on the basis of postoperative imaging as gross total resection (no residual tumour), near-total resection (30 Gy vs no craniospinal irradiation). The primary analysis outcome was the effect of extent of resection by molecular subgroup and the effects of other clinical variables on overall and progression-free survival.FindingsWe included 787 patients with medulloblastoma (86 with WNT tumours, 242 with SHH tumours, 163 with group 3 tumours, and 296 with group 4 tumours) in our multivariable Cox models of progression-free and overall survival. We found that the prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. We identified a progression-free survival benefit for gross total resection over sub-total resection (hazard ratio [HR] 1·45, 95% CI 1·07-1·96, p=0·16) but no overall survival benefit (HR 1·23, 0·87-1·72, p=0·24). We saw no progression-free survival or overall survival benefit for gross total resection compared with near-total resection (HR 1·05, 0·71-1·53, p=0·8158 for progression-free survival and HR 1·14, 0·75-1·72, p=0·55 for overall survival). No significant survival benefit existed for greater extent of resection for patients with WNT, SHH, or group 3 tumours (HR 1·03, 0·67-1·58, p=0·89 for sub-total resection vs gross total resection). For patients with group 4 tumours, gross total resection conferred a benefit to progression-free survival compared with sub-total resection (HR 1·97, 1·22-3·17, p=0·0056), especially for those with metastatic disease (HR 2·22, 1·00-4·93, p=0·050). However, gross total resection had no effect on overall survival compared with sub-total resection in patients with group 4 tumours (HR 1·67, 0·93-2·99, p=0·084).InterpretationThe prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. Although maximum safe surgical resection should remain the standard of care, surgical removal of small residual portions of medulloblastoma is not recommended when the likelihood of neurological morbidity is high because there is no definitive benefit to gross total resection compared with near-total resection.FundingCanadian Cancer Society Research Institute, Terry Fox Research Institute, Canadian Institutes of Health Research, National Institutes of Health, Pediatric Brain Tumor Foundation, and the Garron Family Chair in Childhood Cancer Research.

Published
2016

12. 10025-MPC-3 DIFFERENCE AMONG GENERATIONS IN PATIENTS WITH HISTONE H3-MUTATED GLIOMAS

Author

Fukai, Junya, primary, Hayashi, Nobuhide, additional, Nakatogawa, Hirokazu, additional, Kawaji, Hiroshi, additional, Kodama, Yoshinori, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanematsu, Daisuke, additional, Katsuma, Asako, additional, Sumida, Miho, additional, Kijima, Noriyuki, additional, Okita, Yoshiko, additional, Mori, Kanji, additional, and Kanemura, Yonehiro, additional

Published
2023
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13. 10015-NI-1 PREDICTION OF MGMT PROMOTOR METHYLATION STATUS IN GLIOBLASTOMA BY CONTRAST-ENHANCED T1-WEIGHTED IMAGE

Author

Sanada, Takahiro, primary, Kinoshita, Manabu, additional, Sasaki, Takahiro, additional, Yamamoto, Shota, additional, Fujikawa, Seiya, additional, Fukuyama, Shusei, additional, Hayashi, Nobuhide, additional, Fukai, Junya, additional, Okita, Noriko, additional, Nonaka, Masahiro, additional, Uda, Takehiro, additional, Arita, Hideyuki, additional, Mori, Kanji, additional, Ishibashi, Kenichi, additional, Takano, Koji, additional, Nishida, Namiko, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanematsu, Daisuke, additional, Tanino, Mishie, additional, Kodama, Yoshinori, additional, Mano, Masayuki, additional, and Kanemura, Yonehiro, additional

Published
2023
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14. 10184-BT-14 CLINICAL FEATURE OF HEMISPHERIC GLIOMA WITH H3F3A, PEDIATRIC-TYPE HIGH GRADE GLIOMA, H3 K27-ALTERED, NEC AND DIFFUSE HEMISPHERIC GLIOMA, H3 G34-MUTANT, CNS WHO GRADE 4

Author

Nakatogawa, Hirokazu, primary, Kawaji, Hiroshi, additional, Hayashi, Nobuhide, additional, Fukai, Junya, additional, Kijima, Noriyuki, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanematsu, Daisuke, additional, Katsuma, Asako, additional, Sumida, Miho, additional, Inenaga, Chikanori, additional, Mori, Kanji, additional, and Kanemura, Yonehiro, additional

Published
2023
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15. 10179-NI-8 CLINICORADIOLOGICAL CHARACTERISTICS OF H3 K27-ALTERED THALAMIC GLIOMAS

Author

Hayashi, Nobuhide, primary, Fukai, Junya, additional, Nakatogawa, Hirokazu, additional, Kawaji, Hiroshi, additional, Okita, Yoshiko, additional, Kijima, Noriyuki, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanematsu, Daisuke, additional, Katsuma, Asako, additional, Sumida, Miho, additional, Nakao, Naoyuki, additional, Mori, Kanji, additional, and Kanemura, Yonehiro, additional

Published
2023
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19. Human induced pluripotent stem cell line (ONHi001-A) generated from a patient with infantile neuroaxonal dystrophy having PLA2G6 c.517C>T (p.Q173X) and c.1634A>G (p.K545R) compound heterozygous mutations

Author

Fukusumi, Hayato, primary, Togo, Kazuyuki, additional, Beck, Goichi, additional, Shofuda, Tomoko, additional, Kanematsu, Daisuke, additional, Yamamoto, Atsuyo, additional, Sumida, Miho, additional, Baba, Kousuke, additional, Mochizuki, Hideki, additional, and Kanemura, Yonehiro, additional

Published
2023
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20. Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media

Author

Tateno, Hiroaki, Hiemori, Keiko, Hirayasu, Kazunari, Sougawa, Nagako, Fukuda, Masakazu, Warashina, Masaki, Amano, Makoto, Funakoshi, Taku, Sadamura, Yoshifusa, Miyagawa, Shigeru, Saito, Atsuhiro, Sawa, Yoshiki, Shofuda, Tomoko, Sumida, Miho, Kanemura, Yonehiro, Nakamura, Masaya, Okano, Hideyuki, Onuma, Yasuko, Ito, Yuzuru, Asashima, Makoto, and Hirabayashi, Jun

Published
2017
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21. Prediction of IDH and TERT promoter mutations in low-grade glioma from magnetic resonance images using a convolutional neural network

Author

Fukuma, Ryohei, Yanagisawa, Takufumi, Kinoshita, Manabu, Shinozaki, Takashi, Arita, Hideyuki, Kawaguchi, Atsushi, Takahashi, Masamichi, Narita, Yoshitaka, Terakawa, Yuzo, Tsuyuguchi, Naohiro, Okita, Yoshiko, Nonaka, Masahiro, Moriuchi, Shusuke, Takagaki, Masatoshi, Fujimoto, Yasunori, Fukai, Junya, Izumoto, Shuichi, Ishibashi, Kenichi, Nakajima, Yoshikazu, Shofuda, Tomoko, Kanematsu, Daisuke, Yoshioka, Ema, Kodama, Yoshinori, Mano, Masayuki, Mori, Kanji, Ichimura, Koichi, Kanemura, Yonehiro, and Kishima, Haruhiko

Published
2019
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22. Radiomics and MGMT promoter methylation for prognostication of newly diagnosed glioblastoma

Author

Sasaki, Takahiro, Kinoshita, Manabu, Fujita, Koji, Fukai, Junya, Hayashi, Nobuhide, Uematsu, Yuji, Okita, Yoshiko, Nonaka, Masahiro, Moriuchi, Shusuke, Uda, Takehiro, Tsuyuguchi, Naohiro, Arita, Hideyuki, Mori, Kanji, Ishibashi, Kenichi, Takano, Koji, Nishida, Namiko, Shofuda, Tomoko, Yoshioka, Ema, Kanematsu, Daisuke, Kodama, Yoshinori, Mano, Masayuki, Nakao, Naoyuki, and Kanemura, Yonehiro

Published
2019
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23. Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

Author

Fukuoka, Kohei, Kanemura, Yonehiro, Shofuda, Tomoko, Fukushima, Shintaro, Yamashita, Satoshi, Narushima, Daichi, Kato, Mamoru, Honda-Kitahara, Mai, Ichikawa, Hitoshi, Kohno, Takashi, Sasaki, Atsushi, Hirato, Junko, Hirose, Takanori, Komori, Takashi, Satomi, Kaishi, Yoshida, Akihiko, Yamasaki, Kai, Nakano, Yoshiko, Takada, Ai, Nakamura, Taishi, Takami, Hirokazu, Matsushita, Yuko, Suzuki, Tomonari, Nakamura, Hideo, Makino, Keishi, Sonoda, Yukihiko, Saito, Ryuta, Tominaga, Teiji, Matsusaka, Yasuhiro, Kobayashi, Keiichi, Nagane, Motoo, Furuta, Takuya, Nakada, Mitsutoshi, Narita, Yoshitaka, Hirose, Yuichi, Ohba, Shigeo, Wada, Akira, Shimizu, Katsuyoshi, Kurozumi, Kazuhiko, Date, Isao, Fukai, Junya, Miyairi, Yousuke, Kagawa, Naoki, Kawamura, Atsufumi, Yoshida, Makiko, Nishida, Namiko, Wataya, Takafumi, Yamaoka, Masayoshi, Tsuyuguchi, Naohiro, Uda, Takehiro, Takahashi, Mayu, Nakano, Yoshiteru, Akai, Takuya, Izumoto, Shuichi, Nonaka, Masahiro, Yoshifuji, Kazuhisa, Kodama, Yoshinori, Mano, Masayuki, Ozawa, Tatsuya, Ramaswamy, Vijay, Taylor, Michael D., Ushijima, Toshikazu, Shibui, Soichiro, Yamasaki, Mami, Arai, Hajime, Sakamoto, Hiroaki, Nishikawa, Ryo, Ichimura, Koichi, and on behalf of the Japan Pediatric Molecular Neuro-Oncology Group (JPMNG)

Published
2018
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24. Genetic Alteration May Proceed with a Histological Change in Glioblastoma: A Report from Initially Diagnosed as Nontumor Lesion Cases

Author

TAKEUCHI, Hayato, primary, TAKAHASHI, Yoshinobu, additional, TANIGAWA, Seisuke, additional, OKAMOTO, Takanari, additional, KODAMA, Yoshinori, additional, SHISHIDO-HARA, Yukiko, additional, YOSHIOKA, Ema, additional, SHOFUDA, Tomoko, additional, KANEMURA, Yonehiro, additional, KONISHI, Eiichi, additional, and HASHIMOTO, Naoya, additional

Published
2022
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25. MPC-8 CLINICAL CHARACTERISTICS OF H3 K27-MUTATED GLIOMAS AT MIDLINE AND NEAR MIDLINE

Author

Hayashi, Nobuhide, primary, Fukai, Junya, additional, Nakatogawa, Hirokazu, additional, Kawaji, Hiroshi, additional, Okita, Yoshiko, additional, Kijima, Noriyuki, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanemastu, Daisuke, additional, Katsuma, Asako, additional, Sumida, Miho, additional, Nakao, Naoyuki, additional, Mori, Kanji, additional, and Kanemura, Yonehiro, additional

Published
2022
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26. MPC-15 CLINICAL FEATURE OF NON-MIDLINE GLIOMA WITH H3F3A GENE MUTATION

Author

Nakatogawa, Hirokazu, primary, Kawaji, Hiroshi, additional, Hayashi, Nobuhide, additional, Fukai, Junya, additional, Kijima, Noriyuki, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanematsu, Daisuke, additional, Katsuma, Asako, additional, Sumida, Miho, additional, Inenaga, Chikanori, additional, Mori, Kanji, additional, and Kanemura, Yonehiro, additional

Published
2022
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27. BIOS-05. SANGER SEQUENCING AND COPY-NUMBER ALTERATION ANALYSIS WITH MLPA CAN CLINICALLY CLASSIFY IDH-WILD-TYPE LOWER-GRADE ASTROCYTOMA

Author

Arakawa, Yoshiki, primary, Makino, Yasuhide, additional, Yoshioka, Ema, additional, Shofuda, Tomoko, additional, Kawauchi, Takeshi, additional, Terada, Yukinori, additional, Tanji, Masahiro, additional, Kanematsu, Daisuke, additional, Mineharu, Yohei, additional, Miyamoto, Susumu, additional, and Kanemura, Yonehiro, additional

Published
2022
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28. Lesion location implemented magnetic resonance imaging radiomics for predicting IDH and TERT promoter mutations in grade II/III gliomas

Author

Arita, Hideyuki, Kinoshita, Manabu, Kawaguchi, Atsushi, Takahashi, Masamichi, Narita, Yoshitaka, Terakawa, Yuzo, Tsuyuguchi, Naohiro, Okita, Yoshiko, Nonaka, Masahiro, Moriuchi, Shusuke, Takagaki, Masatoshi, Fujimoto, Yasunori, Fukai, Junya, Izumoto, Shuichi, Ishibashi, Kenichi, Nakajima, Yoshikazu, Shofuda, Tomoko, Kanematsu, Daisuke, Yoshioka, Ema, Kodama, Yoshinori, Mano, Masayuki, Mori, Kanji, Ichimura, Koichi, and Kanemura, Yonehiro

Published
2018
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29. MEDB-30. Subclassification of Group 3/4 medulloblastoma as a potential prognostic biomarker to reduce the dose of craniospinal irradiation in patients with metastatic tumors: A Japanese Pediatric Molecular Neuro-Oncology Group study

Author

Fukuoka, Kohei, primary, Kurihara, Jun, additional, Mori, Makiko, additional, Arakawa, Yuki, additional, Yoshioka, Ema, additional, Shofuda, Tomoko, additional, Matsushita, Yuko, additional, Hibiya, Yuko, additional, Honda, Satoko, additional, Nakazawa, Atsuko, additional, Kiyotani, Chikako, additional, Kagawa, Naoki, additional, Yamasaki, Kai, additional, Ando, Ryo, additional, Keino, Dai, additional, Miyairi, Yosuke, additional, Akai, Takuya, additional, Kanamori, Masayuki, additional, Ishida, Joji, additional, Park, Young-Soo, additional, Kawamura, Atsufumi, additional, Sasaki, Atsushi, additional, Nishikawa, Ryo, additional, Date, Isao, additional, Nagane, Motoo, additional, Koh, Katsuyoshi, additional, Ichimura, Koichi, additional, and Kanemura, Yonehiro, additional

Published
2022
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31. TB-8 Genetic and molecular properties of long-term proliferating tumorsphere -forming glioma derived cells

Author

Kijima, Noriyuki, primary, Kanematsu, Daisuke, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Yamamoto, Atsuyo, additional, Handa, Yukako, additional, Fukusumi, Hayato, additional, Katsuma, Asako, additional, Sumida, Miho, additional, Moriuchi, Shusuke, additional, Nonaka, Masahiro, additional, Okita, Yoshiko, additional, Tsuyuguchi, Naohiro, additional, Uda, Takehiro, additional, Kawashima, Toshiyuki, additional, Fukai, Junya, additional, Kodama, Yoshinori, additional, Mano, Masayuki, additional, Higuchi, Yuichiro, additional, Suemizu, Hiroshi, additional, and Kanemura, Yonehiro, additional

Published
2021
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32. MPC-6 Clinical significance of whole chromosomal aberration signatures in non-metastatic medulloblastomas treated with 18Gy of craniospinal irradiation

Author

Fukuoka, Kohei, primary, Kurihara, Jun, additional, Mori, Makiko, additional, Arakawa, Yuki, additional, Yoshioka, Ema, additional, Shofuda, Tomoko, additional, Matsushita, Yuko, additional, Hibiya, Yuko, additional, Honda, Satoko, additional, Nakazawa, Atsuko, additional, Kiyotani, Chikako, additional, Kagawa, Naoki, additional, Yamasaki, Kai, additional, Ando, Ryo, additional, Keino, Dai, additional, Miyairi, Yosuke, additional, Sasaki, Atsushi, additional, Nishikawa, Ryo, additional, Date, Isao, additional, Nagane, Motoo, additional, Koh, Katsuyoshi, additional, Ichimura, Koichi, additional, and Kanemura, Yonehiro, additional

Published
2021
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33. TMOD-05. GENETIC AND MOLECULAR PROPERTIES OF LONG-TERM PROLIFERATING TUMORSPHERE -FORMING GLIOMA DERIVED CELLS

Author

Kijima, Noriyuki, primary, kanematsu, Daisuke, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Yamamoto, Atsuyo, additional, Handa, Yukako, additional, Fukusumi, Hayato, additional, Katsuma, Asako, additional, Moriuchi, Shusuke, additional, Nonaka, Masahiro, additional, Okita, Yoshiko, additional, Tsuyuguchi, Naohiro, additional, Uda, Takehiro, additional, Kawashima, Toshiyuki, additional, Fukai, Junya, additional, Kodama, Yoshinori, additional, Mano, Masayuki, additional, Higuchi, Yuichiro, additional, Suemizu, Hiroshi, additional, and Kanemura, Yonehiro, additional

Published
2021
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34. Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro

Author

Togo, Kazuyuki, primary, Fukusumi, Hayato, additional, Shofuda, Tomoko, additional, Ohnishi, Hiroshi, additional, Yamazaki, Hiroyuki, additional, Hayashi, Mariko Kato, additional, Kawasaki, Nana, additional, Takei, Nobuyuki, additional, Nakazawa, Takanobu, additional, Saito, Yumiko, additional, Baba, Kousuke, additional, Hashimoto, Hitoshi, additional, Sekino, Yuko, additional, Shirao, Tomoaki, additional, Mochizuki, Hideki, additional, and Kanemura, Yonehiro, additional

Published
2021
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35. Additional file 1 of Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro

Author

Togo, Kazuyuki, Fukusumi, Hayato, Shofuda, Tomoko, Ohnishi, Hiroshi, Yamazaki, Hiroyuki, Hayashi, Mariko Kato, Kawasaki, Nana, Takei, Nobuyuki, Nakazawa, Takanobu, Saito, Yumiko, Baba, Kousuke, Hashimoto, Hitoshi, Sekino, Yuko, Shirao, Tomoaki, Mochizuki, Hideki, and Kanemura, Yonehiro

Subjects
animal diseases, virus diseases
Abstract

Additional file 1: Table 1. Primers for SYBR Green-based qRT-PCR.

Published
2021
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36. Additional file 3 of Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro

Author

Togo, Kazuyuki, Fukusumi, Hayato, Shofuda, Tomoko, Ohnishi, Hiroshi, Yamazaki, Hiroyuki, Hayashi, Mariko Kato, Kawasaki, Nana, Takei, Nobuyuki, Nakazawa, Takanobu, Saito, Yumiko, Baba, Kousuke, Hashimoto, Hitoshi, Sekino, Yuko, Shirao, Tomoaki, Mochizuki, Hideki, and Kanemura, Yonehiro

Abstract

Additional file 3: Table 3. Antibodies used in Western bold analysis.

Published
2021
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37. Additional file 4 of Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro

Author

Togo, Kazuyuki, Fukusumi, Hayato, Shofuda, Tomoko, Ohnishi, Hiroshi, Yamazaki, Hiroyuki, Hayashi, Mariko Kato, Kawasaki, Nana, Takei, Nobuyuki, Nakazawa, Takanobu, Saito, Yumiko, Baba, Kousuke, Hashimoto, Hitoshi, Sekino, Yuko, Shirao, Tomoaki, Mochizuki, Hideki, and Kanemura, Yonehiro

Subjects
nervous system
Abstract

Additional file 4: Figure S1. Gene expression analysis of pre- and postsynaptic markers during the neuronal differentiation of hiPSC-NPCs in the absence and presence of NGF. Dot and box plots showing the expression of postsynaptic markers (drebrin A+E and drebrin A) and a presynaptic marker (synaptophysin) during neuronal differentiation. Statistical analysis was performed using ANOVA with the post hoc Tukey–Kramer method and Student’s t-tests (***p

Published
2021
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38. Additional file 2 of Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro

Author

Togo, Kazuyuki, Fukusumi, Hayato, Shofuda, Tomoko, Ohnishi, Hiroshi, Yamazaki, Hiroyuki, Hayashi, Mariko Kato, Kawasaki, Nana, Takei, Nobuyuki, Nakazawa, Takanobu, Saito, Yumiko, Baba, Kousuke, Hashimoto, Hitoshi, Sekino, Yuko, Shirao, Tomoaki, Mochizuki, Hideki, and Kanemura, Yonehiro

Abstract

Additional file 2: Table 2. Antibodies used in this study.

Published
2021
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39. Additional file 3 of Infrequent RAS mutation is not associated with specific histological phenotype in gliomas

Author

Makino, Yasuhide, Arakawa, Yoshiki, Yoshioka, Ema, Shofuda, Tomoko, Minamiguchi, Sachiko, Kawauchi, Takeshi, Tanji, Masahiro, Kanematsu, Daisuke, Nonaka, Masahiro, Okita, Yoshiko, Kodama, Yoshinori, Mano, Masayuki, Hirose, Takanori, Mineharu, Yohei, Miyamoto, Susumu, and Kanemura, Yonehiro

Abstract

Additional file 3: Supplementary Table 1. Gene-specific primers used for PCR amplifications of the regions of interest in driver genes and quantitative methylation-specific PCR (qMSP) of MGMT promoter.

Published
2021
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40. Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient ( PARK4 ) with SNCA triplication

Author

Fukusumi, Hayato, primary, Togo, Kazuyuki, additional, Sumida, Miho, additional, Nakamori, Masayuki, additional, Obika, Satoshi, additional, Baba, Kousuke, additional, Shofuda, Tomoko, additional, Ito, Daisuke, additional, Okano, Hideyuki, additional, Mochizuki, Hideki, additional, and Kanemura, Yonehiro, additional

Published
2021
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43. Activated leukocyte cell adhesion molecule expression correlates with the WNT subgroup in medulloblastoma and is involved in regulating tumor cell proliferation and invasion

Author

Achiha, Takamune, primary, Kijima, Noriyuki, additional, Kodama, Yoshinori, additional, Kagawa, Naoki, additional, Kinoshita, Manabu, additional, Fujimoto, Yasunori, additional, Nonaka, Masahiro, additional, Fukai, Junya, additional, Inoue, Akihiro, additional, Nishida, Namiko, additional, Yamanaka, Takumi, additional, Harada, Atsuko, additional, Mori, Kanji, additional, Tsuyuguchi, Naohiro, additional, Uda, Takehiro, additional, Ishibashi, Kenichi, additional, Tomogane, Yusuke, additional, Sakamoto, Daisuke, additional, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanematsu, Daisuke, additional, Mano, Masayuki, additional, Luu, Betty, additional, Taylor, Michael D., additional, Kanemura, Yonehiro, additional, and Kishima, Haruhiko, additional

Published
2020
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45. MBRS-38. MOLECULAR CLASSIFICATION AND CLINICAL CHARACTERISTICS OF 236 MEDULLOBLASTOMAS IN JAPAN

Author

Kanemura, Yonehiro, primary, Shofuda, Tomoko, additional, Yoshioka, Ema, additional, Kanematsu, Daisuke, additional, Ichimura, Koichi, additional, Sasaki, Atsushi, additional, Inoue, Takeshi, additional, Hirato, Junko, additional, Kodama, Yoshinori, additional, Mano, Masayuki, additional, Shibui, Soichiro, additional, Arai, Hajime, additional, Sakamoto, Hiroaki, additional, Date, Isao, additional, and Nishikawa, Ryo, additional

Published
2020
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46. MPC-02 Prognostic effects of molecular factors in elderly patients with IDH-wildtype Glioblastomas

Author

Fukai, Junya, primary, Hayashi, Nobuhide, additional, Arita, Hideyuki, additional, Umehara, Toru, additional, Yoshioka, Ema, additional, Shofuda, Tomoko, additional, Kanematsu, Daisuke, additional, Kodama, Yoshinori, additional, Kinoshita, Manabu, additional, Okita, Yoshiko, additional, Nonaka, Masahiro, additional, Uda, Takehiro, additional, Sakamoto, Daisuke, additional, Sasaki, Takahiro, additional, Uematsu, Yuji, additional, Nakao, Naoyuki, additional, Mori, Kanji, additional, and Kanemura, Yonehiro, additional

Published
2020
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47. TMOD-29. ESTABLISHMENT OF PATIENT-DERIVED XENOGRAFTS FROM RARE PRIMARY BRAIN TUMORS

Author

Kijima, Noriyuki, primary, Nakajima, Yoshikazu, additional, Kanematsu, Daisuke, additional, Shofuda, Tomoko, additional, Higuchi, Yuichiro, additional, Suemizu, Hiroshi, additional, Mori, Kanji, additional, Kodama, Yoshinori, additional, Mano, Masayuki, additional, Sasaki, Atsushi, additional, Inoue, Takeshi, additional, Hirato, Junko, additional, Kishima, Haruhiko, additional, and Kanemura, Yonehiro, additional

Published
2020
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48. NI-13 The effectiveness and limitation of survival prediction in primary glioblastoma using machine learning-based texture analysis

Author

Umehara, Toru, primary, Kinoshita, Manabu, additional, Sasaki, Takahiro, additional, Arita, Hideyuki, additional, Yoshioka, Ema, additional, Shofuda, Tomoko, additional, Kodama, Yoshinori, additional, Hirayama, Ryuichi, additional, Kijima, Noriyuki, additional, Kagawa, Naoki, additional, Okita, Yoshiko, additional, Takano, Koji, additional, Uda, Takehiro, additional, Fukai, Junya, additional, Sakamoto, Daisuke, additional, Mori, Kanji, additional, and Kanemura, Yonehiro, additional

Published
2020
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49. TERT promoter mutation associated with multifocal phenotype and poor prognosis in patients with IDH wild-type glioblastoma

Author

Kikuchi, Zensho, primary, Shibahara, Ichiyo, additional, Yamaki, Tetsu, additional, Yoshioka, Ema, additional, Shofuda, Tomoko, additional, Ohe, Rintaro, additional, Matsuda, Ken-ichiro, additional, Saito, Ryuta, additional, Kanamori, Masayuki, additional, Kanemura, Yonehiro, additional, Kumabe, Toshihiro, additional, Tominaga, Teiji, additional, and Sonoda, Yukihiko, additional

Published
2020
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