Search

Your search keyword '"Shin, Cheolmin"' showing total 30 results
Start Over Author "Shin, Cheolmin" Search Limiters Full Text
30 results on '"Shin, Cheolmin"'

2. A Multi-Center, Open-Label, Single-Arm Study to Investigate the Early Effectiveness of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression Using a Mobile Self-Monitoring Application.

Author

Kim, Junhyung, Lee, Seung-Hoon, Shin, Cheolmin, Han, Kyu-Man, Cho, Sung Joon, Hong, Narei, and Han, Changsu

Subjects
HAMILTON Depression Inventory, GENERALIZED anxiety disorder, MOBILE health, MENTAL depression, INTRANASAL medication
Abstract

This study assesses the early effectiveness of esketamine nasal spray (ESK) in adults with treatment-resistant depression (TRD) 1 day after the first administration, as monitored through self-assessment via the mobile application, Esketamine Continuing Assessment for Relapse Prevention (EsCARe). In this multi-center, open-label, single-arm study, adults aged 18–65 years diagnosed with TRD after failing at least two antidepressant therapies were enrolled from five tertiary hospitals in South Korea. During the induction period, participants self-administered ESK twice weekly and used the EsCARe app daily to record mood, sleep, and somatic symptoms. Key clinical assessments, the Patient Health Questionnaire-9 (PHQ-9), the Hamilton Depression Rating Scale (HAMD), and the Generalized Anxiety Disorder Scale (GAD-7), were measured at baseline and at weeks 2 and 4. The reliability and validity of EsCARe was assessed. The treatment results indicated significant improvements in depressive and anxiety symptoms, with notable reductions in the PHQ-9 and the GAD-7 by week 2, and the HAMD by week 4. The EsCARe app reliably and validly monitored depressive symptoms and demonstrated a significant reduction in depressive symptoms 1 day after the first administration of ESK. Using ESK, complemented by mobile self-monitoring, effectively reduces the symptoms of TRD early in the treatment course. Integrating mobile health technology into the therapeutic regimen highlights a significant advancement in managing TRD, offering patients and clinicians immediate feedback on treatment efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Investigating the effectiveness of a smart mental health intervention (inMind) for stress reduction during pharmacological treatment for mild to moderate major depressive disorders: Study protocol for a randomized control trial

Author

Kim, Junhyung, primary, Shin, Cheolmin, additional, Han, Kyu-Man, additional, Lee, Moon-Soo, additional, Jeong, Hyun-Ghang, additional, Pae, Chi-Un, additional, Patkar, Ashwin A., additional, Masand, Prakash M., additional, and Han, Changsu, additional

Published
2023
Full Text
View/download PDF

11. Ketamine in Major Depressive Disorder: Mechanisms and Future Perspectives

Author

Shin, Cheolmin and Kim, Yong-Ku

Subjects
medicine.medical_specialty, medicine.drug_class, Antidepressant, Review Article, Major depressive disorder, Dissociative, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Ketamine, Psychiatry, Suicidal ideation, Biological Psychiatry, N-Methyl-D-aspartic acid (NMDA) receptor antagonist, business.industry, Psychotomimetic, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, NMDA receptor, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Major depressive disorder (MDD) is a serious psychiatric illness that causes functional impairment in many people. While monoaminergic antidepressants have been used to effectively treat MDD, these antidepressants have limitations in that they have delayed onset of action and many patients remain treatment-resistant. Therefore, there is a need to develop antidepressants with a novel target, and researchers have directed their attention to the glutamatergic system. Ketamine, although developed as an anesthetic, has been found to produce an antidepressant effect at sub-anesthetic doses via N-Methyl-D-aspartic acid (NMDA) receptor blockade as well as NMDA receptor- independent pathways. A single infusion of ketamine produced rapid improvement in clinical symptoms to a considerable level and led to the resolution of serious depressive symptoms, including imminent suicidal ideation, in patients with MDD. A series of recent randomized controlled trials have provided a high level of evidence for the therapeutic efficacy of ketamine treatment in MDD and presented new insights on the dose, usage, and route of administration of ketamine as an antidepressant. With this knowledge, it is expected that ketamine treatment protocols for MDD will be established as a treatment option available in clinical practice. However, long-term safety must be taken into consideration as ketamine has abuse potential and it is associated with psychological side effects such as dissociative or psychotomimetic effects.

Published
2020

15. Synergy through Integration of Wearable EEG and Virtual Reality for Mild Cognitive Impairment and Mild Dementia Screening: Protocol Design and Feasibility Study (Preprint)

Author

Lee, Bohee, primary, Lee, Taeheon, additional, Jeon, Hyungsin, additional, Lee, Songsub, additional, Kim, Kibum, additional, Cho, Wanhee, additional, Hwang, Jeonghwan, additional, Chae, Yong-Wook, additional, Jung, Jin-Man, additional, Kang, Hyo Jin, additional, Kim, Nan Hee, additional, Shin, Cheolmin, additional, and Jang, Jaeson, additional

Published
2021
Full Text
View/download PDF

16. The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer’s Dementia: A Double-Blind Randomized Placebo-Controlled Trial

Author

Youn, HyunChul, primary, Lee, Kang Joon, additional, Kim, Shin-Gyeom, additional, Cho, Seong-Jin, additional, Kim, Woo Jung, additional, Lee, Won Joon, additional, Hwang, Jae Yeon, additional, Han, Changsu, additional, Shin, Cheolmin, additional, and Jung, Han-yong, additional

Published
2021
Full Text
View/download PDF

21. The Development of Evidence-Based Guideline for Diagnosis and Management of Headache in Korea

Author

Kim, Sun Mi, primary, Ko, Young-Hoon, additional, Yoon, Seoyoung, additional, Kang, Won Sub, additional, Kim, Hye-Geum, additional, Park, Hye Youn, additional, Shin, Cheolmin, additional, Um, Yoo Hyun, additional, Youn, Soyoung, additional, Lee, Jae-Hon, additional, Jang, Seung-Ho, additional, Jeon, Sang Won, additional, Jeon, Hong Jun, additional, Chung, Seockhoon, additional, Choi, Jae-Won, additional, Han, Kyu-Man, additional, and Lee, Sang-Yeol, additional

Published
2019
Full Text
View/download PDF

30. Effect of Frailty on Depression among Patients with Late-life Depression: A Test of Anger, Anxiety, and Resilience as Mediators.

Author

Kim J, Jeong HG, Lee MS, Pae CU, Patkar AA, Jeon SW, Shin C, and Han C

Abstract

Objective: While the association between depression and frailty in the elderly population has been investigated, the psychological factors that mediate such a relationship remain unknown. The identification of psychological factors in interventions for depression treatment in the elderly may assist in the treatment and care. We aimed to explore the mediating effects of anger, anxiety, and resilience on the link between frailty and depression symptoms in patients with late-life depression., Methods: A sample of 203 older adults completed questionnaires that assessed depression, anger, resilience, and anxiety. To measure frailty, participants were evaluated using a self-rated health questionnaire, weight-adjusted waist index related to sarcopenia, and weight-adjusted handgrip strength to evaluate weakness. A mediation model was tested, hypothesizing that anger, anxiety, and resilience would partially mediate the strength of the frailty-depression link in the elderly., Results: Only self-rated health showed a significant association with depressive symptoms in late-life depression. Our study demonstrated that frailty has both direct and indirect associations with depression, mediated by anger, resilience, and anxiety., Conclusion: Given that anger, resilience, and anxiety influence the link between self-rated health and depression, interventions that lead to increased resilience and decreased anger and anxiety may be promising to reduce depressive symptoms in older adults with depression.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results