Search

Your search keyword '"Seppala L"' showing total 28 results
Start Over Author "Seppala L" Search Limiters Full Text
28 results on '"Seppala L"'

1. Exploration of user involvement and collaboration in a co-design project : a case study

Author

Seppala, L. M.

Subjects
362.1
Abstract

Introduction: Collaborative design (co-design) is an approach that includes ‘users’ in the design process. This approach is growing in popularity amongst companies seeking to develop a competitive advantage in the field of outdoor clothing and equipment. Health research is steadily developing a substantial evidence base of the effectiveness of public involvement in research, however, in the co-design research field, there is a less developed evidence base concerning user involvement aspects. This qualitative case study presents an exploration of the factors that influence the experience of user involvement in a study utilising a co-design approach. The case concerned is the New Dynamics of Ageing-funded study ‘Design for Ageing Well’, which presented an opportunity to explore both the co-design mechanisms utilised along with the experiences of the individuals involved in the study. They included research team members, project partners (e.g., outdoor clothing manufacturers), User Reference Group members (members of the public) and User Advisory Group members (also members of the public). Methods: A single case study approach was utilised. Sampling was purposeful, taken from the above four groups of stakeholders. Data collection methods included one-to-one semi-structured interviews (35 people) and non-participant observations (44 total hours). Findings: This study demonstrated that strong project management, including leadership and change management, is crucial for a successful co-design experience. A clear vision, plus the aim and purpose of the co-design process, need to be communicated to all stakeholders. The three main factors that impact public involvement in co-design are: • The facilitator’s knowledge and skills regarding co-design methods and moderation; • Multidisciplinary collaboration; • The management of the co-design setting. Conclusion: Effective public involvement in co-design research requires suitable leadership, project management, and a clear communication strategy, and attention should be paid to the facilitation and management of the co-design setting. These objectives are best achieved when user needs are heard and embedded in all aspects of the co-design approach.

Published
2017

2. The role of plasma concentrations and drug characteristics of beta‐blockers in fall risk of older persons

Author

Ploegmakers, K. J., primary, van Poelgeest, E. P., additional, Seppala, L. J., additional, van Dijk, S. C., additional, de Groot, L. C. P. G. M., additional, Oliai Araghi, S., additional, van Schoor, N. M., additional, Stricker, B., additional, Swart, K. M. A., additional, Uitterlinden, A. G., additional, Mathôt, R. A. A., additional, and van der Velde, N., additional

Published
2023
Full Text
View/download PDF

3. Are higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?

Author

Pronk, A. C., van Poelgeest, E. P., Seppala, L. J., Ploegmakers, K. J., Stricker, B. H., Swart, K. M.A., van Dijk, S. C., Oliai Araghi, S., de Groot, L. C.P.G.M., van Schoor, N. M., Mathôt, R. A.A., van der Velde, N., Pronk, A. C., van Poelgeest, E. P., Seppala, L. J., Ploegmakers, K. J., Stricker, B. H., Swart, K. M.A., van Dijk, S. C., Oliai Araghi, S., de Groot, L. C.P.G.M., van Schoor, N. M., Mathôt, R. A.A., and van der Velde, N.

Abstract

Purpose: Antidepressants are well-established fall-risk increasing drugs (FRIDs) and therefore falls should be considered an important adverse drug event (ADE) of antidepressants. However, not all antidepressant users experience fall incidents and factors associated with increased fall risk among antidepressant users are incompletely understood. Our objective was to explore whether antidepressant plasma concentrations are associated with falls in older antidepressant users. Methods: For this study, we included antidepressant users of the multicenter B-PROOF study. Fall incidents were recorded prospectively using fall calendars. Antidepressant plasma concentrations were analyzed by Liquid chromatography-mass spectrometry (LC–MS) at baseline and at 2 years follow-up. The associations between the observed antidepressant concentration and fall risk were assessed using Cox proportional hazard and logistic regression models and adjusted for potential confounders. Results: In total 93 selective serotonin reuptake inhibitor (SSRI) and 41 antidepressant (TCA) users were identified. There was a significant association between baseline TCA plasma concentration and fall risk within users (HR 2.50, 95% CI 1.07–5.87, crude model). In the adjusted model, there were no significant associations between concentrations of SSRIs and fall risk. Conclusion: There might be an association between plasma concentrations of TCAs and the risk of falling in older users. However, these results needs to be interpreted with caution considering the small sample size and accompanying limitation of confinement to crude analyses. Therefore, these novel findings need to replicated in a larger cohort, preferably including adjustment for potential confounders and more frequent measures of plasma concentrations is needed.

Published
2023

4. Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults

Author

Pronk, A. C., Seppala, L. J., Trajanoska, K., Stringa, N., van de Loo, B., de Groot, L. C.P.G.M., van Schoor, N. M., Koskeridis, F., Markozannes, G., Ntzani, E., Uitterlinden, A. G., Rivadeneira, F., Stricker, B. H., van der Velde, N., Pronk, A. C., Seppala, L. J., Trajanoska, K., Stringa, N., van de Loo, B., de Groot, L. C.P.G.M., van Schoor, N. M., Koskeridis, F., Markozannes, G., Ntzani, E., Uitterlinden, A. G., Rivadeneira, F., Stricker, B. H., and van der Velde, N.

Abstract

Background Antidepressant use has been associated with increased fall risk. Antidepressant-related adverse drug reactions (e.g. orthostatic hypotension) depend partly on genetic variation. We hypothesized that candidate genetic polymorphisms are associated with fall risk in older antidepressant users. Methods The association between antidepressant use and falls was cross-sectionally investigated in a cohort of Dutch older adults by logistic regression analyses. In case of significant interaction product term of antidepressant use and candidate polymorphism, the association between the variant genotype and fall risk was assessed within antidepressant users and the association between antidepressant use and fall risk was investigated stratified per genotype. Secondly, a look-up of the candidate genes was performed in an existing genome-wide association study on drug-related falls in antidepressant users within the UK Biobank. In antidepressant users, genetic associations for our candidate polymorphisms for fall history were investigated. Results In antidepressant users(n = 566), for rs28371725 (CYP2D6*41) fall risk was decreased in TC/variant allele carriers compared to CC/non-variant allele carriers (OR = 0.45, 95% CI 0.26–0.80). Concerning rs1057910 (CYP2C9*3), fall risk was increased in CA/variant allele carriers compared to AA/non-variant allele carriers (OR = 1.95, 95% CI 1.17–3.27). Regarding, rs1045642 (ABCB1), fall risk was increased in AG/variant allele carriers compared to GG/non-variant allele carriers (OR = 1.69, 95% CI 1.07–2.69). Concerning the ABCB1-haplotype (rs1045642/rs1128503), fall risk was increased in AA-AA/variant allele carriers compared to GG-GG/non-variant allele carriers (OR = 1.86, 95% CI 1.05–3.29). In the UK Biobank, in antidepressant users(n = 34,000) T/variant-allele of rs28371725 (CYP2D*41) was associated with increased fall risk (OR = 1.06, 95% CI 1.01–1.12). G/non-variant-allele of rs4244285 (CY2C19*2) was associated with decrease

Published
2022

5. Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults

Author

Pronk, A. C., primary, Seppala, L. J., additional, Trajanoska, K., additional, Stringa, N., additional, van de Loo, B., additional, de Groot, L. C. P. G. M., additional, van Schoor, N. M., additional, Koskeridis, F., additional, Markozannes, G., additional, Ntzani, E., additional, Uitterlinden, A. G., additional, Rivadeneira, F., additional, Stricker, B. H., additional, and van der Velde, N., additional

Published
2022
Full Text
View/download PDF

6. Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment

Author

Abu-Shawareb, H, Acree, R, Adams, P, Adams, J, Addis, B, Aden, R, Adrian, P, Afeyan, BB, Aggleton, M, Aghaian, L, Aguirre, A, Aikens, D, Akre, J, Albert, F, Albrecht, M, Albright, BJ, Albritton, J, Alcala, J, Alday, C, Alessi, DA, Alexander, N, Alfonso, J, Alfonso, N, Alger, E, Ali, SJ, Ali, ZA, Alley, WE, Amala, P, Amendt, PA, Amick, P, Ammula, S, Amorin, C, Ampleford, DJ, Anderson, RW, Anklam, T, Antipa, N, Appelbe, B, Aracne-Ruddle, C, Araya, E, Arend, M, Arnold, P, Arnold, T, Asay, J, Atherton, LJ, Atkinson, D, Atkinson, R, Auerbach, JM, Austin, B, Auyang, L, Awwal, AS, Ayers, J, Ayers, S, Ayers, T, Azevedo, S, Bachmann, B, Back, CA, Bae, J, Bailey, DS, Bailey, J, Baisden, T, Baker, KL, Baldis, H, Barber, D, Barberis, M, Barker, D, Barnes, A, Barnes, CW, Barrios, MA, Barty, C, Bass, I, Batha, SH, Baxamusa, SH, Bazan, G, Beagle, JK, Beale, R, Beck, BR, Beck, JB, Bedzyk, M, Beeler, RG, Behrendt, W, Belk, L, Bell, P, Belyaev, M, Benage, JF, Bennett, G, Benedetti, LR, Benedict, LX, Berger, R, Bernat, T, Bernstein, LA, Berry, B, Bertolini, L, Besenbruch, G, Betcher, J, Bettenhausen, R, Betti, R, Bezzerides, B, Bhandarkar, SD, Bickel, R, Biener, J, Biesiada, T, Bigelow, K, Bigelow-Granillo, J, Bigman, V, Bionta, RM, Birge, NW, Bitter, M, Black, AC, Bleile, R, Bleuel, DL, Bliss, E, Blue, B, Boehly, T, Boehm, K, Boley, CD, Bonanno, R, Bond, EJ, Bond, T, Bonino, MJ, Borden, M, Bourgade, J-L, Bousquet, J, Bowers, J, Bowers, M, Boyd, R, Bozek, A, Bradley, DK, Bradley, KS, Bradley, PA, Bradley, L, Brannon, L, Brantley, PS, Braun, D, Braun, T, Brienza-Larsen, K, Briggs, TM, Britten, J, Brooks, ED, Browning, D, Bruhn, MW, Brunner, TA, Bruns, H, Brunton, G, Bryant, B, Buczek, T, Bude, J, Buitano, L, Burkhart, S, Burmark, J, Burnham, A, Burr, R, Busby, LE, Butlin, B, Cabeltis, R, Cable, M, Cabot, WH, Cagadas, B, Caggiano, J, Cahayag, R, Caldwell, SE, Calkins, S, Callahan, DA, Calleja-Aguirre, J, Camara, L, Camp, D, Campbell, EM, Campbell, JH, Carey, B, Carey, R, Carlisle, K, Carlson, L, Carman, L, Carmichael, J, Carpenter, A, Carr, C, Carrera, JA, Casavant, D, Casey, A, Casey, DT, Castillo, A, Castillo, E, Castor, JI, Castro, C, Caughey, W, Cavitt, R, Celeste, J, Celliers, PM, Cerjan, C, Chandler, G, Chang, B, Chang, C, Chang, J, Chang, L, Chapman, R, Chapman, T, Chase, L, Chen, H, Chen, K, Chen, L-Y, Cheng, B, Chittenden, J, Choate, C, Chou, J, Chrien, RE, Chrisp, M, Christensen, K, Christensen, M, Christopherson, AR, Chung, M, Church, JA, Clark, A, Clark, DS, Clark, K, Clark, R, Claus, L, Cline, B, Cline, JA, Cobble, JA, Cochrane, K, Cohen, B, Cohen, S, Collette, MR, Collins, G, Collins, LA, Collins, TJB, Conder, A, Conrad, B, Conyers, M, Cook, AW, Cook, D, Cook, R, Cooley, JC, Cooper, G, Cope, T, Copeland, SR, Coppari, F, Cortez, J, Cox, J, Crandall, DH, Crane, J, Craxton, RS, Cray, M, Crilly, A, Crippen, JW, Cross, D, Cuneo, M, Cuotts, G, Czajka, CE, Czechowicz, D, Daly, T, Danforth, P, Darbee, R, Darlington, B, Datte, P, Dauffy, L, Davalos, G, Davidovits, S, Davis, P, Davis, J, Dawson, S, Day, RD, Day, TH, Dayton, M, Deck, C, Decker, C, Deeney, C, DeFriend, KA, Deis, G, Delamater, ND, Delettrez, JA, Demaret, R, Demos, S, Dempsey, SM, Desjardin, R, Desjardins, T, Desjarlais, MP, Dewald, EL, DeYoreo, J, Diaz, S, Dimonte, G, Dittrich, TR, Divol, L, Dixit, SN, Dixon, J, Dodd, ES, Dolan, D, Donovan, A, Donovan, M, Döppner, T, Dorrer, C, Dorsano, N, Douglas, MR, Dow, D, Downie, J, Downing, E, Dozieres, M, Draggoo, V, Drake, D, Drake, RP, Drake, T, Dreifuerst, G, DuBois, DF, DuBois, PF, Dunham, G, Dylla-Spears, R, Dymoke-Bradshaw, AKL, Dzenitis, B, Ebbers, C, Eckart, M, Eddinger, S, Eder, D, Edgell, D, Edwards, MJ, Efthimion, P, Eggert, JH, Ehrlich, B, Ehrmann, P, Elhadj, S, Ellerbee, C, Elliott, NS, Ellison, CL, Elsner, F, Emerich, M, Engelhorn, K, England, T, English, E, Epperson, P, Epstein, R, Erbert, G, Erickson, MA, Erskine, DJ, Erlandson, A, Espinosa, RJ, Estes, C, Estabrook, KG, Evans, S, Fabyan, A, Fair, J, Fallejo, R, Farmer, N, Farmer, WA, Farrell, M, Fatherley, VE, Fedorov, M, Feigenbaum, E, Feit, M, Ferguson, W, Fernandez, JC, Fernandez-Panella, A, Fess, S, Field, JE, Filip, CV, Fincke, JR, Finn, T, Finnegan, SM, Finucane, RG, Fischer, M, Fisher, A, Fisher, J, Fishler, B, Fittinghoff, D, Fitzsimmons, P, Flegel, M, Flippo, KA, Florio, J, Folta, J, Folta, P, Foreman, LR, Forrest, C, Forsman, A, Fooks, J, Foord, M, Fortner, R, Fournier, K, Fratanduono, DE, Frazier, N, Frazier, T, Frederick, C, Freeman, MS, Frenje, J, Frey, D, Frieders, G, Friedrich, S, Froula, DH, Fry, J, Fuller, T, Gaffney, J, Gales, S, Le Galloudec, B, Le Galloudec, KK, Gambhir, A, Gao, L, Garbett, WJ, Garcia, A, Gates, C, Gaut, E, Gauthier, P, Gavin, Z, Gaylord, J, Geissel, M, Génin, F, Georgeson, J, Geppert-Kleinrath, H, Geppert-Kleinrath, V, Gharibyan, N, Gibson, J, Gibson, C, Giraldez, E, Glebov, V, Glendinning, SG, Glenn, S, Glenzer, SH, Goade, S, Gobby, PL, Goldman, SR, Golick, B, Gomez, M, Goncharov, V, Goodin, D, Grabowski, P, Grafil, E, Graham, P, Grandy, J, Grasz, E, Graziani, F, Greenman, G, Greenough, JA, Greenwood, A, Gregori, G, Green, T, Griego, JR, Grim, GP, Grondalski, J, Gross, S, Guckian, J, Guler, N, Gunney, B, Guss, G, Haan, S, Hackbarth, J, Hackel, L, Hackel, R, Haefner, C, Hagmann, C, Hahn, KD, Hahn, S, Haid, BJ, Haines, BM, Hall, BM, Hall, C, Hall, GN, Hamamoto, M, Hamel, S, Hamilton, CE, Hammel, BA, Hammer, JH, Hampton, G, Hamza, A, Handler, A, Hansen, S, Hanson, D, Haque, R, Harding, D, Harding, E, Hares, JD, Harris, DB, Harte, JA, Hartouni, EP, Hatarik, R, Hatchett, S, Hauer, AA, Havre, M, Hawley, R, Hayes, J, Hayes, S, Hayes-Sterbenz, A, Haynam, CA, Haynes, DA, Headley, D, Heal, A, Heebner, JE, Heerey, S, Heestand, GM, Heeter, R, Hein, N, Heinbockel, C, Hendricks, C, Henesian, M, Heninger, J, Henrikson, J, Henry, EA, Herbold, EB, Hermann, MR, Hermes, G, Hernandez, JE, Hernandez, VJ, Herrmann, MC, Herrmann, HW, Herrera, OD, Hewett, D, Hibbard, R, Hicks, DG, Hill, D, Hill, K, Hilsabeck, T, Hinkel, DE, Ho, DD, Ho, VK, Hoffer, JK, Hoffman, NM, Hohenberger, M, Hohensee, M, Hoke, W, Holdener, D, Holdener, F, Holder, JP, Holko, B, Holunga, D, Holzrichter, JF, Honig, J, Hoover, D, Hopkins, D, Berzak Hopkins, L, Hoppe, M, Hoppe, ML, Horner, J, Hornung, R, Horsfield, CJ, Horvath, J, Hotaling, D, House, R, Howell, L, Hsing, WW, Hu, SX, Huang, H, Huckins, J, Hui, H, Humbird, KD, Hund, J, Hunt, J, Hurricane, OA, Hutton, M, Huynh, KH-K, Inandan, L, Iglesias, C, Igumenshchev, IV, Izumi, N, Jackson, M, Jackson, J, Jacobs, SD, James, G, Jancaitis, K, Jarboe, J, Jarrott, LC, Jasion, D, Jaquez, J, Jeet, J, Jenei, AE, Jensen, J, Jimenez, J, Jimenez, R, Jobe, D, Johal, Z, Johns, HM, Johnson, D, Johnson, MA, Gatu Johnson, M, Johnson, RJ, Johnson, S, Johnson, SA, Johnson, T, Jones, K, Jones, O, Jones, M, Jorge, R, Jorgenson, HJ, Julian, M, Jun, BI, Jungquist, R, Kaae, J, Kabadi, N, Kaczala, D, Kalantar, D, Kangas, K, Karasiev, VV, Karasik, M, Karpenko, V, Kasarky, A, Kasper, K, Kauffman, R, Kaufman, MI, Keane, C, Keaty, L, Kegelmeyer, L, Keiter, PA, Kellett, PA, Kellogg, J, Kelly, JH, Kemic, S, Kemp, AJ, Kemp, GE, Kerbel, GD, Kershaw, D, Kerr, SM, Kessler, TJ, Key, MH, Khan, SF, Khater, H, Kiikka, C, Kilkenny, J, Kim, Y, Kim, Y-J, Kimko, J, Kimmel, M, Kindel, JM, King, J, Kirkwood, RK, Klaus, L, Klem, D, Kline, JL, Klingmann, J, Kluth, G, Knapp, P, Knauer, J, Knipping, J, Knudson, M, Kobs, D, Koch, J, Kohut, T, Kong, C, Koning, JM, Koning, P, Konior, S, Kornblum, H, Kot, LB, Kozioziemski, B, Kozlowski, M, Kozlowski, PM, Krammen, J, Krasheninnikova, NS, Kraus, B, Krauser, W, Kress, JD, Kritcher, AL, Krieger, E, Kroll, JJ, Kruer, WL, Kruse, MKG, Kucheyev, S, Kumbera, M, Kumpan, S, Kunimune, J, Kustowski, B, Kwan, TJT, Kyrala, GA, Laffite, S, Lafon, M, LaFortune, K, Lahmann, B, Lairson, B, Landen, OL, Langenbrunner, J, Lagin, L, Land, T, Lane, M, Laney, D, Langdon, AB, Langer, SH, Langro, A, Lanier, NE, Lanier, TE, Larson, D, Lasinski, BF, Lassle, D, LaTray, D, Lau, G, Lau, N, Laumann, C, Laurence, A, Laurence, TA, Lawson, J, Le, HP, Leach, RR, Leal, L, Leatherland, A, LeChien, K, Lechleiter, B, Lee, A, Lee, M, Lee, T, Leeper, RJ, Lefebvre, E, Leidinger, J-P, LeMire, B, Lemke, RW, Lemos, NC, Le Pape, S, Lerche, R, Lerner, S, Letts, S, Levedahl, K, Lewis, T, Li, CK, Li, H, Li, J, Liao, W, Liao, ZM, Liedahl, D, Liebman, J, Lindford, G, Lindman, EL, Lindl, JD, Loey, H, London, RA, Long, F, Loomis, EN, Lopez, FE, Lopez, H, Losbanos, E, Loucks, S, Lowe-Webb, R, Lundgren, E, Ludwigsen, AP, Luo, R, Lusk, J, Lyons, R, Ma, T, Macallop, Y, MacDonald, MJ, MacGowan, BJ, Mack, JM, Mackinnon, AJ, MacLaren, SA, MacPhee, AG, Magelssen, GR, Magoon, J, Malone, RM, Malsbury, T, Managan, R, Mancini, R, Manes, K, Maney, D, Manha, D, Mannion, OM, Manuel, AM, Mapoles, E, Mara, G, Marcotte, T, Marin, E, Marinak, MM, Mariscal, C, Mariscal, DA, Mariscal, EF, Marley, EV, Marozas, JA, Marquez, R, Marshall, CD, Marshall, FJ, Marshall, M, Marshall, S, Marticorena, J, Martinez, D, Maslennikov, I, Mason, D, Mason, RJ, Masse, L, Massey, W, Masson-Laborde, P-E, Masters, ND, Mathisen, D, Mathison, E, Matone, J, Matthews, MJ, Mattoon, C, Mattsson, TR, Matzen, K, Mauche, CW, Mauldin, M, McAbee, T, McBurney, M, Mccarville, T, McCrory, RL, McEvoy, AM, McGuffey, C, Mcinnis, M, McKenty, P, McKinley, MS, McLeod, JB, McPherson, A, Mcquillan, B, Meamber, M, Meaney, KD, Meezan, NB, Meissner, R, Mehlhorn, TA, Mehta, NC, Menapace, J, Merrill, FE, Merritt, BT, Merritt, EC, Meyerhofer, DD, Mezyk, S, Mich, RJ, Michel, PA, Milam, D, Miller, C, Miller, D, Miller, DS, Miller, E, Miller, EK, Miller, J, Miller, M, Miller, PE, Miller, T, Miller, W, Miller-Kamm, V, Millot, M, Milovich, JL, Minner, P, Miquel, J-L, Mitchell, S, Molvig, K, Montesanti, RC, Montgomery, DS, Monticelli, M, Montoya, A, Moody, JD, Moore, AS, Moore, E, Moran, M, Moreno, JC, Moreno, K, Morgan, BE, Morrow, T, Morton, JW, Moses, E, Moy, K, Muir, R, Murillo, MS, Murray, JE, Murray, JR, Munro, DH, Murphy, TJ, Munteanu, FM, Nafziger, J, Nagayama, T, Nagel, SR, Nast, R, Negres, RA, Nelson, A, Nelson, D, Nelson, J, Nelson, S, Nemethy, S, Neumayer, P, Newman, K, Newton, M, Nguyen, H, Di Nicola, J-MG, Di Nicola, P, Niemann, C, Nikroo, A, Nilson, PM, Nobile, A, Noorai, V, Nora, R, Norton, M, Nostrand, M, Note, V, Novell, S, Nowak, PF, Nunez, A, Nyholm, RA, O'Brien, M, Oceguera, A, Oertel, JA, Okui, J, Olejniczak, B, Oliveira, J, Olsen, P, Olson, B, Olson, K, Olson, RE, Opachich, YP, Orsi, N, Orth, CD, Owen, M, Padalino, S, Padilla, E, Paguio, R, Paguio, S, Paisner, J, Pajoom, S, Pak, A, Palaniyappan, S, Palma, K, Pannell, T, Papp, F, Paras, D, Parham, T, Park, H-S, Pasternak, A, Patankar, S, Patel, MV, Patel, PK, Patterson, R, Patterson, S, Paul, B, Paul, M, Pauli, E, Pearce, OT, Pearcy, J, Pedrotti, B, Peer, A, Pelz, LJ, Penetrante, B, Penner, J, Perez, A, Perkins, LJ, Pernice, E, Perry, TS, Person, S, Petersen, D, Petersen, T, Peterson, DL, Peterson, EB, Peterson, JE, Peterson, JL, Peterson, K, Peterson, RR, Petrasso, RD, Philippe, F, Phipps, TJ, Piceno, E, Ping, Y, Pickworth, L, Pino, J, Plummer, R, Pollack, GD, Pollaine, SM, Pollock, BB, Ponce, D, Ponce, J, Pontelandolfo, J, Porter, JL, Post, J, Poujade, O, Powell, C, Powell, H, Power, G, Pozulp, M, Prantil, M, Prasad, M, Pratuch, S, Price, S, Primdahl, K, Prisbrey, S, Procassini, R, Pruyne, A, Pudliner, B, Qiu, SR, Quan, K, Quinn, M, Quintenz, J, Radha, PB, Rainer, F, Ralph, JE, Raman, KS, Raman, R, Rambo, P, Rana, S, Randewich, A, Rardin, D, Ratledge, M, Ravelo, N, Ravizza, F, Rayce, M, Raymond, A, Raymond, B, Reed, B, Reed, C, Regan, S, Reichelt, B, Reis, V, Reisdorf, S, Rekow, V, Remington, BA, Rendon, A, Requieron, W, Rever, M, Reynolds, H, Reynolds, J, Rhodes, J, Rhodes, M, Richardson, MC, Rice, B, Rice, NG, Rieben, R, Rigatti, A, Riggs, S, Rinderknecht, HG, Ring, K, Riordan, B, Riquier, R, Rivers, C, Roberts, D, Roberts, V, Robertson, G, Robey, HF, Robles, J, Rocha, P, Rochau, G, Rodriguez, J, Rodriguez, S, Rosen, M, Rosenberg, M, Ross, G, Ross, JS, Ross, P, Rouse, J, Rovang, D, Rubenchik, AM, Rubery, MS, Ruiz, CL, Rushford, M, Russ, B, Rygg, JR, Ryujin, BS, Sacks, RA, Sacks, RF, Saito, K, Salmon, T, Salmonson, JD, Sanchez, J, Samuelson, S, Sanchez, M, Sangster, C, Saroyan, A, Sater, J, Satsangi, A, Sauers, S, Saunders, R, Sauppe, JP, Sawicki, R, Sayre, D, Scanlan, M, Schaffers, K, Schappert, GT, Schiaffino, S, Schlossberg, DJ, Schmidt, DW, Schmitt, MJ, Schneider, DHG, Schneider, MB, Schneider, R, Schoff, M, Schollmeier, M, Schölmerich, M, Schroeder, CR, Schrauth, SE, Scott, HA, Scott, I, Scott, JM, Scott, RHH, Scullard, CR, Sedillo, T, Seguin, FH, Seka, W, Senecal, J, Sepke, SM, Seppala, L, Sequoia, K, Severyn, J, Sevier, JM, Sewell, N, Seznec, S, Shah, RC, Shamlian, J, Shaughnessy, D, Shaw, M, Shaw, R, Shearer, C, Shelton, R, Shen, N, Sherlock, MW, Shestakov, AI, Shi, EL, Shin, SJ, Shingleton, N, Shmayda, W, Shor, M, Shoup, M, Shuldberg, C, Siegel, L, Silva, FJ, Simakov, AN, Sims, BT, Sinars, D, Singh, P, Sio, H, Skulina, K, Skupsky, S, Slutz, S, Sluyter, M, Smalyuk, VA, Smauley, D, Smeltser, RM, Smith, C, Smith, I, Smith, J, Smith, L, Smith, R, Sohn, R, Sommer, S, Sorce, C, Sorem, M, Soures, JM, Spaeth, ML, Spears, BK, Speas, S, Speck, D, Speck, R, Spears, J, Spinka, T, Springer, PT, Stadermann, M, Stahl, B, Stahoviak, J, Stanton, LG, Steele, R, Steele, W, Steinman, D, Stemke, R, Stephens, R, Sterbenz, S, Sterne, P, Stevens, D, Stevers, J, Still, CB, Stoeckl, C, Stoeffl, W, Stolken, JS, Stolz, C, Storm, E, Stone, G, Stoupin, S, Stout, E, Stowers, I, Strauser, R, Streckart, H, Streit, J, Strozzi, DJ, Suratwala, T, Sutcliffe, G, Suter, LJ, Sutton, SB, Svidzinski, V, Swadling, G, Sweet, W, Szoke, A, Tabak, M, Takagi, M, Tambazidis, A, Tang, V, Taranowski, M, Taylor, LA, Telford, S, Theobald, W, Thi, M, Thomas, A, Thomas, CA, Thomas, I, Thomas, R, Thompson, IJ, Thongstisubskul, A, Thorsness, CB, Tietbohl, G, Tipton, RE, Tobin, M, Tomlin, N, Tommasini, R, Toreja, AJ, Torres, J, Town, RPJ, Townsend, S, Trenholme, J, Trivelpiece, A, Trosseille, C, Truax, H, Trummer, D, Trummer, S, Truong, T, Tubbs, D, Tubman, ER, Tunnell, T, Turnbull, D, Turner, RE, Ulitsky, M, Upadhye, R, Vaher, JL, VanArsdall, P, VanBlarcom, D, Vandenboomgaerde, M, VanQuinlan, R, Van Wonterghem, BM, Varnum, WS, Velikovich, AL, Vella, A, Verdon, CP, Vermillion, B, Vernon, S, Vesey, R, Vickers, J, Vignes, RM, Visosky, M, Vocke, J, Volegov, PL, Vonhof, S, Von Rotz, R, Vu, HX, Vu, M, Wall, D, Wall, J, Wallace, R, Wallin, B, Walmer, D, Walsh, CA, Walters, CF, Waltz, C, Wan, A, Wang, A, Wang, Y, Wark, JS, Warner, BE, Watson, J, Watt, RG, Watts, P, Weaver, J, Weaver, RP, Weaver, S, Weber, CR, Weber, P, Weber, SV, Wegner, P, Welday, B, Welser-Sherrill, L, Weiss, K, Widmann, K, Wheeler, GF, Whistler, W, White, RK, Whitley, HD, Whitman, P, Wickett, ME, Widmayer, C, Wiedwald, J, Wilcox, R, Wilcox, S, Wild, C, Wilde, BH, Wilde, CH, Wilhelmsen, K, Wilke, MD, Wilkens, H, Wilkins, P, Wilks, SC, Williams, EA, Williams, GJ, Williams, W, Williams, WH, Wilson, DC, Wilson, B, Wilson, E, Wilson, R, Winters, S, Wisoff, J, Wittman, M, Wolfe, J, Wong, A, Wong, KW, Wong, L, Wong, N, Wood, R, Woodhouse, D, Woodruff, J, Woods, DT, Woods, S, Woodworth, BN, Wooten, E, Wootton, A, Work, K, Workman, JB, Wright, J, Wu, M, Wuest, C, Wysocki, FJ, Xu, H, Yamaguchi, M, Yang, B, Yang, ST, Yatabe, J, Yeamans, CB, Yee, BC, Yi, SA, Yin, L, Young, B, Young, CS, Young, CV, Young, P, Youngblood, K, Zacharias, R, Zagaris, G, Zaitseva, N, Zaka, F, Ze, F, Zeiger, B, Zika, M, Zimmerman, GB, Zobrist, T, Zuegel, JD, Zylstra, AB, Indirect Drive ICF Collaboration, Collaboration, Indirect Drive ICF, AWE Plc, Lawrence Livermore National Laboratory, and U.S Department of Energy

Subjects
General Physics, 02 Physical Sciences, General Physics and Astronomy, Indirect Drive ICF Collaboration, 01 Mathematical Sciences, 09 Engineering
Abstract

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.

Published
2022

7. Deprescribing tool for STOPPFall (screening tool of older persons prescriptions in older adults with high fall risk) items

Author

Seppala, L. J., Petrovic, M., Jesper Ryg, Bahat, G., Topinkova, E., Szczerbińska, K., Cammen, T. J., Hartikainen, S., Ilhan, B., Landi, F., Morrissey, Y., Mair, A., Gutiérrez-Valencia, M., Emmelot-Vonk, M. H., Caballero Mora, M. A., Michael Denkinger, Crome, P., Jackson, S. H. D., Correa-Pérez, A., Knol, W., Soulis, G., Adalsteinn Gudmundsson, Ziere, G., Wehling, M., O’mahony, D., Antonio Cherubini, and Nathalie van der Velde

Subjects
screening, fall risk, Medicine and Health Sciences, Deprescribing tool, older persons prescriptions, STOPPFall
Abstract

Background: Health care professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier. To support clinicians in the management of FRIDs and to facilitate the deprescribing process, a deprescribing tool was developed by a European expert group for STOPPFall (Screening Tool of Older Persons Prescriptions in older adults with high fall risk) items. Methods: STOPPFall was created using an expert Delphi consensus process in 2019 and in 2020, 24 panellists from EuGMS SIG on Pharmacology and Task and Finish on FRIDs completed deprescribing tool questionnaire. To develop the questionnaire, a Medline literature search was performed. The panellists were asked to indicate for every medication class a possible need for stepwise withdrawal and strategy for withdrawal. They were asked in which situations withdrawal should be performed. Furthermore, panellists were requested to indicate those symptoms patients should be monitored for after deprescribing and a possible need for follow-ups. Results: Practical deprescribing guidance was developed for STOPPFall medication classes. For each medication class, a decision tree algorithm was developed including steps from medication review to symptom monitoring after medication withdrawal. Conclusion: STOPPFall was combined with a practical deprescribing tool designed to optimize medication review. This practical guide can help overcome current reluctance towards deprescribing in clinical practice by providing an up-to-date and straightforward source of expert knowledge.

Published
2020

8. [Editorial Note] EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): position on knowledge dissemination, management, and future research

Author

Seppala, L J, van der Velde, N, Masud, T, Blain, H, Petrovic, M, van der Cammen, T J, Szczerbińska, K, Hartikainen, S, Kenny, R A, Ryg, J, Eklund, P, Topinková, E, Mair, A, Laflamme, L, Rajkumar, C, EuGMS Task and Finish Group on Fall-Risk-Increasing Drugs, and others

Abstract

Falls are under-recognized as adverse drug events. Healthcare professionals are reluctant to withdraw fall-risk-increasing medications. The EuGMS Task and Finish group on fall-risk-increasing drugs (FRIDs) proposes in this paper its recommendations on dissemination of knowledge about, management of, and future research on FRIDs. Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe. The EuGMS Task and Finish group is developing educational materials to facilitate knowledge dissemination for healthcare professionals and older people. In addition, steps in primary prevention through judicious prescribing, deprescribing of FRIDs (withdrawal and dose reduction), and gaps in current research are outlined in this position paper.

Published
2019

9. EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research

Author

Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., Szczerbińska, K., Hartikainen, S., Kenny, R. A., Ryg, J., Eklund, P., Topinková, E., Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutiérrez-Valencia, M., Caballero-Mora, MA, Landi, F., Emmelot-Vonk, M. H., Cherubini, A., Baeyens, J. P., Correa-Pérez, A., Gudmundsson, A., Marengoni, A., O’Mahony, D., Parekh, N., Pisa, F. E., Rajkumar, C., Wehling, M., Ziere, G., and the EuGMS Special Interest Group on Pharmacology

Abstract

Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe. The EuGMS Task and Finish group is developing educational materials to facilitate knowledge dissemination for healthcare professionals and older people. In addition, steps in primary prevention through judicious prescribing, deprescribing of FRIDs (withdrawal and dose reduction), and gaps in current research are outlined in this position paper.

Published
2019

10. EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research

Author

Seppala, L. J. (author), van der Velde, N. (author), Masud, T. (author), Blain, H. (author), Petrovic, M. (author), van der Cammen, T.J.M. (author), Szczerbińska, K. (author), Hartikainen, S. (author), Kenny, R. A. (author), Seppala, L. J. (author), van der Velde, N. (author), Masud, T. (author), Blain, H. (author), Petrovic, M. (author), van der Cammen, T.J.M. (author), Szczerbińska, K. (author), Hartikainen, S. (author), and Kenny, R. A. (author)

Abstract

Falls are under-recognized as adverse drug events. Healthcare professionals are reluctant to withdraw fall-risk-increasing medications. The EuGMS Task and Finish group on fall-risk-increasing drugs (FRIDs) proposes in this paper its recommendations on dissemination of knowledge about, management of, and future research on FRIDs. Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe. The EuGMS Task and Finish group is developing educational materials to facilitate knowledge dissemination for healthcare professionals and older people. In addition, steps in primary prevention through judicious prescribing, deprescribing of FRIDs (withdrawal and dose reduction), and gaps in current research are outlined in this position paper., Applied Ergonomics and Design

Published
2019
Full Text
View/download PDF

11. EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research

Author

MS Geriatrie, Circulatory Health, Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., Szczerbinska, K., Hartikainen, S., Kenny, R. A., Ryg, J., Eklund, P., Topinkova, E., Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutierrez-Valencia, M., Caballero-Mora, M. A., Landi, F., Emmelot-Vonk, M. H., Cherubini, A., Baeyens, J. P., Correa-Perez, A., Gudmundsson, A., Marengoni, A., O'Mahony, D., Parekh, N., Pisa, F. E., Rajkumar, C., Wehling, M., Ziere, G., MS Geriatrie, Circulatory Health, Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., Szczerbinska, K., Hartikainen, S., Kenny, R. A., Ryg, J., Eklund, P., Topinkova, E., Mair, A., Laflamme, L., Thaler, H., Bahat, G., Gutierrez-Valencia, M., Caballero-Mora, M. A., Landi, F., Emmelot-Vonk, M. H., Cherubini, A., Baeyens, J. P., Correa-Perez, A., Gudmundsson, A., Marengoni, A., O'Mahony, D., Parekh, N., Pisa, F. E., Rajkumar, C., Wehling, M., and Ziere, G.

Published
2019

12. Age modifies the association between apathy and recurrent falling in Dutch ambulant older persons with a high fall risk: Recurrent falling in Dutch outpatients, does apathy play a role?

Author

Henstra, M. J., Houbolt, C. M., Seppala, L. J., de Rooij, S. E., Rhebergen, D., Stek, M. L., van der Velde, N., Amsterdam Neuroscience, Geriatrics, Other Research, APH - Aging & Later Life, AMS - Ageing & Morbidty, Internal medicine, Psychiatry, APH - Mental Health, General practice, and Lifelong Learning, Education & Assessment Research Network (LEARN)

Subjects
BASE-LINE, Apathy, LATE-LIFE DEPRESSION, VASCULAR-DISEASE, ADULTS, Community-dwelling, Recurrent falling, COGNITIVE IMPAIRMENT, VALIDATION, Aging and cognition, COMMUNITY, PARKINSONS-DISEASE, INCREASING DRUGS, Falls, MATTER
Abstract

Apathy, a common and disabling behavioural syndrome in older persons, has been associated with impaired physical performance and executive dysfunction. Both are fall risk factors and they share pathophysiological pathway. We cross-sectionally examined the association between apathy and recurrent falling (≥2 falls in the past 12 months) and number of falls in the past 12 months in 243 outpatients aged ≥65 years with ≥3 fall risk-factors visiting a fall-clinic after a fall. We calculated Odds Ratio's (ORs), Incidence Rate Ratio's (IRRs) and their 95% Confidential Intervals (CI95) using multivariable regression and negative binomial regression analyses. We adjusted for cognitive functioning, depression, the use of fall risk increasing drugs, visual impairment, urine incontinence, comorbidity, smoking, use of alcohol, body mass index (BMI), and the number of months between assessment of fall risk and of apathy. We assessed effect modification by age and gender. In our study, apathy was independently associated with recurrent falling in patients aged 65–75 years: OR 2.8 (CI95 1.0–7.7). Overall, patients with apathy experienced 1.46 times as many falls in the past 12 months compared to patients without apathy (IRR 1.46 (CI95 1.0–2.1). To conclude, in high fall-risk older outpatients, apathy was cross-sectionally associated with recurrent falling in patients aged 65–75 years and the number of falls. Apathy appeared to be especially relevant in relation to falling in this age group. Whether apathy predicts recurrent falling is yet to be determined.

Published
2018

13. A report on the health and social care listening event

Author

Williamson, T, Ball, E, Choucri, LP, Collier, E, Devitt, P, Franks, H, Howarth, ML, Lythgoe, J, Mcandrew, S, Roberts, D, Rowswell, K, Seppala, L, Wray, J, and Yates-Bolton, N

Subjects
health_and_wellbeing
Abstract

The purpose of the Listening Event was to enable a wide range of people, including professionals working in statutory, voluntary and other organisations and members of the public, to ‘have a say’ about health and social care and what we as a University can do for and with these partners and the public. We particularly wanted to hear about key concerns of the University such as:\ud • Strengthening community engagement and partnerships\ud • Health and social care training we should be providing, for whom, and how this is delivered\ud • Ideas relating to the University themes including media, use of space and buildings, human rights, social justice and security \ud • Research topics we should be addressing\ud However the main strength of the Listening Event approach is that topics for discussion are mostly led by participants who attend. On this occasion, the\ud discussion topics were very much focused on the concerns of participants and lots of information and ideas were generated. The task now is for the event planning team to review the discussion notes and identify what can be\ud addressed and how, in the short, medium and long term. This planning will be taking place over the Autumn in 2011, and any participants or readers of this report are more than welcome to get in touch to work with us or add their views.\ud The purpose of this report is to record all discussion summaries for sharing amongst participants and others. It is important that participants especially get to read what others had said at the event. The report will lead to changes in University practices such as the content of some of our courses and new business ideas and relationships will also be explored. The event itself provided a useful means of public engagement that others may wish to adopt.

Published
2011

14. Linear Collider Physics Resource Book for Snowmass 2001, 2: Higgs and Supersymmetry Studies

Author

Abe, T., Arkani-Hamed, N., Asner, David Mark, Baer, H., Bagger, Jonathan A., Balazs, Csaba, Baltay, C., Barker, T., Barklow, T., Barron, J., Baur, Ulrich J., Beach, R., Bellwied, R., Bigi, Ikaros I.Y., Blochinger, C., Boege, S., Bolton, T., Bower, G., Brau, James E., Breidenbach, Martin, Brodsky, Stanley J., Burke, David L., Burrows, Philip N., Butler, Joel N., Chakraborty, Dhiman, Cheng, Hsin-Chia, Chertok, Maxwell Benjamin, Choi, Seong-Youl, Cinabro, David, Corcella, Gennaro, Cordero, R.K., Danielson, N., Davoudiasl, Hooman, Dawson, S., Denner, Ansgar, Derwent, P., Diaz, Marco Aurelio, Dima, M., Dittmaier, Stefan, Dixit, M., Dixon, Lance J., Dobrescu, Bogdan A., Doncheski, M.A., Duckwitz, M., Dunn, J., Early, J., Erler, Jens, Feng, Jonathan L., Ferretti, C., Fisk, H.Eugene, Fraas, H., Freitas, A., Frey, R., Gerdes, David W., Gibbons, L., Godbole, R., Godfrey, S., Goodman, E., Gopalakrishna, Shrihari, Graf, N., Grannis, Paul D., Gronberg, Jeffrey Baton, Gunion, John F., Haber, Howard E., Han, Tao, Hawkings, Richard, Hearty, Christopher, Heinemeyer, Sven, Hertzbach, Stanley S., Heusch, Clemens A., Hewett, JoAnne L., Hikasa, K., Hiller, G., Hoang, Andre H., Hollebeek, Robert, Iwasaki, M., Jacobsen, Robert Gibbs, Jaros, John Alan, Juste, A., Kadyk, John A., Kalinowski, J., Kalyniak, P., Kamon, Teruki, Karlen, Dean, Keller, L, Koltick, D., Kribs, Graham D., Kronfeld, Andreas Samuel, Leike, A., Logan, Heather E., Lykken, Joseph D., Macesanu, Cosmin, Magill, Stephen R., Marciano, William Joseph, Markiewicz, Thomas W., Martin, S., Maruyama, T., Matchev, Konstantin Tzvetanov, Monig, Klaus, Montgomery, Hugh E., Moortgat-Pick, Gudrid A., Moreau, G., Mrenna, Stephen, Murakami, Brandon, Murayama, Hitoshi, Nauenberg, Uriel, Neal, H., Newman, B., Nojiri, Mihoko M., Orr, Lynne H., Paige, F., Para, A., Pathak, S., Peskin, Michael E., Plehn, Tilman, Porter, F., Potter, C., Prescott, C., Rainwater, David Landry, Raubenheimer, Tor O., Repond, J., Riles, Keith, Rizzo, Thomas Gerard, Ronan, Michael T., Rosenberg, L., Rosner, Jonathan L., Roth, M., Rowson, Peter C., Schumm, Bruce Andrew, Seppala, L., Seryi, Andrei, Siegrist, J., Sinev, N., Skulina, K., Sterner, K.L., Stewart, I., Su, S., Tata, Xerxes Ramyar, Telnov, Valery I., Teubner, Thomas, Tkaczyk, S., Turcot, Andre S., van Bibber, Karl A., Van Kooten, Rick J., Vega, R., Wackeroth, Doreen, Wagner, D., Waite, Anthony P., Walkowiak, Wolfgang, Weiglein, Georg, Wells, James Daniel, Wester, William Carl, III, Williams, B., Wilson, G., Wilson, R., Winn, D., Woods, M., Wudka, J., Yakovlev, Oleg I., Yamamoto, H., and Yang, Hai Jun

Subjects
High Energy Physics::Phenomenology, Physics::Accelerator Physics, High Energy Physics::Experiment, Particle Physics - Experiment
Abstract

This Resource Book reviews the physics opportunities of a next-generation e+e- linear collider and discusses options for the experimental program. Part 2 reviews the possible experiments on Higgs bosons and supersymmetric particles that can be done at a linear collider. This Resource Book reviews the physics opportunities of a next-generation e+e- linear collider and discusses options for the experimental program. Part 2 reviews the possible experiments on Higgs bosons and supersymmetric particles that can be done at a linear collider.

Published
2001

15. Broadband Diffractive Lens

Author

LAWRENCE LIVERMORE NATIONAL LAB CA, Ceglio, N. M., Hawryluk, A. M., Gaines, D. P., London, R. A., Seppala, L. G., LAWRENCE LIVERMORE NATIONAL LAB CA, Ceglio, N. M., Hawryluk, A. M., Gaines, D. P., London, R. A., and Seppala, L. G.

Abstract

Significant progress has been made toward solving the century-old problem of chromatic aberrations in diffractive optics. Our approach exploits modern materials and microfabrication technology and is very different from the 'purely diffractive strategy', which is commonly employed and which results in multiple diffractive elements separated by a finite distance. We have developed a Fresnel zone plate lens comprised of a serial stack of patterned minus-filters which allows broadband radiation to be focussed (or imaged) without longitudinal or transverse chromatic aberrations. Diffractive optics, such as the Fresnel zone plate shown in Figure 1, are commonly used for imaging and focussing radiation at wavelengths for which refraction is not a viable option.

Published
1992

16. Linear Collider Physics Resource Book for Snowmass 2001 - Part 1: Introduction

Author

Abe, T., Arkani-Hamed, N., Asner, D., Baer, H., Bagger, J., Balazs, C., Baltay, C., Barker, T., Barklow, T., Barron, J., Baur, U., Beach, R., Bellwied, R., Bigi, I., Blöchinger, C., Boege, S., Bolton, T., Bower, G., Brau, J., Breidenbach, M., Brodsky, S. J., Burke, D., Burrows, P., Butler, J. N., Chakraborty, D., Cheng, H. C., Chertok, M., Choi, S. Y., Cinabro, D., Corcella, G., Cordero, R. K., Danielson, N., Davoudiasl, H., Dawson, S., Denner, A., Derwent, P., Diaz, M. A., Dima, M., Dittmaier, S., Dixit, M., Dixon, L., Dobrescu, B., Doncheski, M. A., Duckwitz, M., Dunn, J., Early, J., Erler, J., Feng, J. L., Ferretti, C., Fisk, H. E., Fraas, H., Freitas, A., Frey, R., Gerdes, D., Gibbons, L., Godbole, R., Godfrey, S., Goodman, E., Gopalakrishna, S., Graf, N., Grannis, P. D., Gronberg, J., Gunion, J., Haber, H. E., Han, T., Hawkings, R., Hearty, C., Heinemeyer, S., Hertzbach, S. S., Heusch, C., Hewett, J., Hikasa, K., Hiller, G., Hoang, A., Hollebeek, R., Iwasaki, M., Jacobsen, R., Jaros, J., Juste, A., Kadyk, J., Kalinowski, J., Kalyniak, P., Kamon, T., Karlen, D., Keller, L., Koltick, D., Kribs, G., Kronfeld, A., Leike, A., Logan, H. E., Lykken, J., Macesanu, C., Magill, S., Marciano, W., Markiewicz, T. W., Martin, S., Maruyama, T., Matchev, K., Moenig, K., Montgomery, H. E., Moortgat-Pick, G., Moreau, G., Mrenna, S., Murakami, B., Murayama, H., Nauenberg, U., Neal, H., Newman, B., Nojiri, M., Orr, L. H., Paige, F., Para, A., Pathak, S., Peskin, M. E., Plehn, T., Porter, F., Potter, C., Prescott, C., Rainwater, D., Raubenheimer, T., Repond, J., Riles, K., Rizzo, T., Ronan, M., Rosenberg, L., Rosner, J., Roth, M., Rowson, P., Schumm, B., Seppala, L., Seryi, A., Siegrist, J., Sinev, N., Skulina, K., Sterner, K. L., Stewart, I., Su, S., Tata, X., Telnov, V., Teubner, T., Tkaczyk, S., Turcot, A. S., Bibber, K., Kooten, R., Vega, R., Wackeroth, D., Wagner, D., Waite, A., Walkowiak, W., Weiglein, G., James Daniel Wells, W Wester, Iii, Williams, B., Wilson, G., Wilson, R., Winn, D., Woods, M., Wudka, J., Yakovlev, O., Yamamoto, H., and Yang, H. J.

Subjects
hep-ex, Physics::Accelerator Physics, High Energy Physics::Experiment, hep-ph, Particle Physics - Experiment, Particle Physics - Phenomenology
Abstract

This Resource Book reviews the physics opportunities of a next-generation e+e- linear collider and discusses options for the experimental program. Part 1 contains the table of contents and introduction and gives a summary of the case for a 500 GeV linear collider.

17. Linear Collider Physics Resource Book for Snowmass 2001 - Part 4: Theoretical, Accelerator, and Experimental Options

Author

Abe, T., Arkani-Hamed, N., Asner, D., Baer, H., Bagger, J., Balazs, C., Baltay, C., Barker, T., Barklow, T., Barron, J., Baur, U., Beach, R., Bellwied, R., Bigi, I., Blöchinger, C., Boege, S., Bolton, T., Bower, G., Brau, J., Breidenbach, M., Brodsky, S. J., Burke, D., Burrows, P., Butler, J. N., Chakraborty, D., Cheng, H. C., Chertok, M., Choi, S. Y., Cinabro, D., Corcella, G., Cordero, R. K., Danielson, N., Davoudiasl, H., Dawson, S., Ansgar Denner, Derwent, P., Diaz, M. A., Dima, M., Dittmaier, S., Dixit, M., Dixon, L., Dobrescu, B., Doncheski, M. A., Duckwitz, M., Dunn, J., Early, J., Erler, J., Feng, J. L., Ferretti, C., Fisk, H. E., Fraas, H., Freitas, A., Frey, R., Gerdes, D., Gibbons, L., Godbole, R., Godfrey, S., Goodman, E., Gopalakrishna, S., Graf, N., Grannis, P. D., Gronberg, J., Gunion, J., Haber, H. E., Han, T., Hawkings, R., Hearty, C., Heinemeyer, S., Hertzbach, S. S., Heusch, C., Hewett, J., Hikasa, K., Hiller, G., Hoang, A., Hollebeek, R., Iwasaki, M., Jacobsen, R., Jaros, J., Juste, A., Kadyk, J., Kalinowski, J., Kalyniak, P., Kamon, T., Karlen, D., Keller, L., Koltick, D., Kribs, G., Kronfeld, A., Leike, A., Logan, H. E., Lykken, J., Macesanu, C., Magill, S., Marciano, W., Markiewicz, T. W., Martin, S., Maruyama, T., Matchev, K., Moenig, K., Montgomery, H. E., Moortgat-Pick, G., Moreau, G., Mrenna, S., Murakami, B., Murayama, H., Nauenberg, U., Neal, H., Newman, B., Nojiri, M., Orr, L. H., Paige, F., Para, A., Pathak, S., Peskin, M. E., Plehn, T., Porter, F., Potter, C., Prescott, C., Rainwater, D., Raubenheimer, T., Repond, J., Riles, K., Rizzo, T., Ronan, M., Rosenberg, L., Rosner, J., Roth, M., Rowson, P., Schumm, B., Seppala, L., Seryi, A., Siegrist, J., Sinev, N., Skulina, K., Sterner, K. L., Stewart, I., Su, S., Tata, X., Telnov, V., Teubner, T., Tkaczyk, S., Turcot, A. S., Bibber, K., Kooten, R., Vega, R., Wackeroth, D., Wagner, D., Waite, A., Walkowiak, W., Weiglein, G., Wells, J. D., W Wester, Iii, Williams, B., Wilson, G., Wilson, R., Winn, D., Woods, M., Wudka, J., Yakovlev, O., Yamamoto, H., and Yang, H. J.

Subjects
Physics::Instrumentation and Detectors, hep-ex, Physics::Accelerator Physics, High Energy Physics::Experiment, hep-ph, Particle Physics - Experiment, Particle Physics - Phenomenology
Abstract

This Resource Book reviews the physics opportunities of a next-generation e+e- linear collider and discusses options for the experimental program. Part 4 discusses options for the linear collider program, at a number of levels. First, it presents a broad review of physics beyond the Standard Model, indicating how the linear collider is relevant to each possible pathway. Next, it surveys options for the accelerator and experimental plan, including the questions of the running scenario, the issue of one or two interaction regions, and the options for positron polarization, photon-photon collisions, and e-e- collisions. Finally, it reviews the detector design issues for the linear collider and presents three possible detector designs.

24. Experimental comparison of a Shack-Hartmann sensor and a phase-shifting interferometer for large-optics metrology applications.

Author

Koch JA, Presta RW, Sacks RA, Zacharias RA, Bliss ES, Dailey MJ, Feldman M, Grey AA, Holdener FR, Salmon JT, Seppala LG, Toeppen JS, Van Atta L, Van Wonterghem BM, Whistler WT, Winters SE, and Woods BW

Abstract

We performed a direct side-by-side comparison of a Shack-Hartmann wave-front sensor and a phase-shifting interferometer for the purpose of characterizing large optics. An expansion telescope of our own design allowed us to measure the surface figure of a 400-mm-square mirror with both instruments simultaneously. The Shack-Hartmann sensor produced data that closely matched the interferometer data over spatial scales appropriate for the lenslet spacing, and much of the <20-nm rms systematic difference between the two measurements was due to diffraction artifacts that were present in the interferometer data but not in the Shack-Hartmann sensor data. The results suggest that Shack-Hartmann sensors could replace phase-shifting interferometers for many applications, with particular advantages for large-optic metrology.

Published
2000
Full Text
View/download PDF

25. Condenser optics, partial coherence, and imaging for soft-x-ray projection lithography.

Author

Sommargren GE and Seppala LG

Abstract

A condenser system couples the radiation source to an imaging system, controlling the uniformity and partial coherence at the object, which ultimately affects the characteristics of the aerial image. A soft-x-ray projection lithography system based on a ring-field imaging system and a laser-produced plasma x-ray source places considerable constraints on the design of a condenser system. Two designs are proposed, critical illumination and Köhler illumination, each of which requires three mirrors and scanning for covering the entire ring field with the required uniformity and partial coherence. Images based on Hopkins' formulation of partially coherent imaging are simulated.

Published
1993
Full Text
View/download PDF

26. Low-cost, high-resolution, single-structure array telescopes for imaging of low-Earth-orbit satellites.

Author

Massie NA, Oster Y, Poe G, Seppala L, and Shao M

Abstract

Telescopes that are designed for the unconventional imaging of near-Earth satellites must follow unique design rules. The costs must be reduced substantially over those of the conventional telescope designs, and the design must accommodate a technique to circumvent atmospheric distortion of the image. Apertures of 12 m and more along with altitude-altitude mounts that provide high tracking rates are required. A novel design for such a telescope, optimized for speckle imaging, has been generated. Its mount closely resembles a radar mount, and it does not use the conventional dome. Costs for this design are projected to be considerably lower than those for the conventional designs. Results of a design study are presented with details of the electro-optical and optical designs.

Published
1992
Full Text
View/download PDF

27. Optical Interpretation of the Merit Function in Grey's Lens Design Program.

Author

Seppala LG

Abstract

A ray and wavefront analysis is the basis of an interpretation of the aberration balancing merit function in Grey's lens design program. From each of several field angles, this program traces a coarse grid of rays through an axially symmetric optical system. A polynomial in a region around each ray describes the wave error. This polynomial includes terms (through second order) in aperture, field angle, and wavelength variables. The coefficients of the terms in the polynomial are calculated from real and differential ray trace data. The merit function is the variance of the wave error, obtained by squaring and integrating the polynomials over appropriate ranges of the variables. Distortion is removed from the wave error polynomials and is included in the merit function in a unique manner.

Published
1974
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results