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1. A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Author

Li, S., Spitz, N., Ghantous, A., Abrishamcar, S., Reimann, B., Marques, I., Silver, M.J., Aguilar-Lacasaña, S., Kitaba, N., Rezwan, F.I., Röder, Stefan, Sirignano, L., Tuhkanen, J., Mancano, G., Sharp, G.C., Metayer, C., Morimoto, L., Stein, D.J., Zar, H.J., Alfano, R., Nawrot, T., Wang, C., Kajantie, E., Keikkala, E., Mustaniemi, S., Ronkainen, J., Sebert, S., Silva, W., Vääräsmäki, M., Jaddoe, V.W.V., Bernstein, R.M., Prentice, A.M., Cosin-Tomas, M., Dwyer, T., Håberg, S.E., Herceg, Z., Magnus, M.C., Munthe-Kaas, M.C., Page, C.M., Völker, M., Gilles, M., Send, T., Witt, S., Zillich, L., Gagliardi, L., Richiardi, L., Czamara, D., Räikkönen, K., Chatzi, L., Vafeiadi, M., Arshad, S.H., Ewart, S, Plusquin, M., Felix, J.F., Moore, S.E., Vrijheid, M., Holloway, J.W., Karmaus, W., Herberth, Gunda, Zenclussen, Ana Claudia, Streit, F., Lahti, J., Hüls, A., Hoang, T.T., London, S.J., Wiemels, J.L., Li, S., Spitz, N., Ghantous, A., Abrishamcar, S., Reimann, B., Marques, I., Silver, M.J., Aguilar-Lacasaña, S., Kitaba, N., Rezwan, F.I., Röder, Stefan, Sirignano, L., Tuhkanen, J., Mancano, G., Sharp, G.C., Metayer, C., Morimoto, L., Stein, D.J., Zar, H.J., Alfano, R., Nawrot, T., Wang, C., Kajantie, E., Keikkala, E., Mustaniemi, S., Ronkainen, J., Sebert, S., Silva, W., Vääräsmäki, M., Jaddoe, V.W.V., Bernstein, R.M., Prentice, A.M., Cosin-Tomas, M., Dwyer, T., Håberg, S.E., Herceg, Z., Magnus, M.C., Munthe-Kaas, M.C., Page, C.M., Völker, M., Gilles, M., Send, T., Witt, S., Zillich, L., Gagliardi, L., Richiardi, L., Czamara, D., Räikkönen, K., Chatzi, L., Vafeiadi, M., Arshad, S.H., Ewart, S, Plusquin, M., Felix, J.F., Moore, S.E., Vrijheid, M., Holloway, J.W., Karmaus, W., Herberth, Gunda, Zenclussen, Ana Claudia, Streit, F., Lahti, J., Hüls, A., Hoang, T.T., London, S.J., and Wiemels, J.L.

Abstract

Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.

Published
2024

2. Response to the letter by Esteves et al.

Author

Send, T. S., Gilles, M., Codd, V., Wolf, I. A. C., Bardtke, S., Streit, F., Strohmaier, J., Frank, J., Schendel, D., Sütterlin, M. W., Denniff, M., Laucht, M., Samani, N. J., Deuschle, M., Rietschel, M., and Witt, S. H.

Published
2018
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3. DNA methylation signatures of aggression and closely related constructs:a meta-analysis of epigenome-wide studies across the lifespan

Author

van Dongen, J. (Jenny), Hagenbeek, F. A. (Fiona A.), Suderman, M. (Matthew), Roetman, P. J. (Peter J.), Sugden, K. (Karen), Chiocchetti, A. G. (Andreas G.), Ismail, K. (Khadeeja), Mulder, R. H. (Rosa H.), Hafferty, J. D. (Jonathan D.), Adams, M. J. (Mark J.), Walker, R. M. (Rosie M.), Morris, S. W. (Stewart W.), Lahti, J. (Jari), Kupers, L. K. (Leanne K.), Escaramis, G. (Georgia), Alemany, S. (Silvia), Bonder, M. J. (Marc Jan), Meijer, M. (Mandy), Ip, H. F. (Hill F.), Jansen, R. (Rick), Baselmans, B. M. (Bart M. L.), Parmar, P. (Priyanka), Lowry, E. (Estelle), Streit, F. (Fabian), Sirignano, L. (Lea), Send, T. S. (Tabea S.), Frank, J. (Josef), Jylhava, J. (Juulia), Wang, Y. (Yunzhang), Mishra, P. P. (Pashupati Prasad), Colins, O. F. (Olivier F.), Corcoran, D. L. (David L.), Poulton, R. (Richie), Mill, J. (Jonathan), Hannon, E. (Eilis), Arseneault, L. (Louise), Korhonen, T. (Tellervo), Vuoksimaa, E. (Eero), Felix, J. F. (Janine F.), Bakermans-Kranenburg, M. J. (Marian J.), Campbell, A. (Archie), Czamara, D. (Darina), Binder, E. (Elisabeth), Corpeleijn, E. (Eva), Gonzalez, J. R. (Juan R.), Grazuleviciene, R. (Regina), Gutzkow, K. B. (Kristine B.), Evandt, J. (Jorunn), Vafeiadi, M. (Marina), Klein, M. (Marieke), van der Meer, D. (Dennis), Ligthart, L. (Lannie), Kluft, C. (Cornelis), Davies, G. E. (Gareth E.), Hakulinen, C. (Christian), Keltikangas-Jarvinen, L. (Liisa), Franke, B. (Barbara), Freitag, C. M. (Christine M.), Konrad, K. (Kerstin), Hervas, A. (Amaia), Fernandez-Rivas, A. (Aranzazu), Vetro, A. (Agnes), Raitakari, O. (Olli), Lehtimaki, T. (Terho), Vermeiren, R. (Robert), Strandberg, T. (Timo), Raikkonen, K. (Katri), Snieder, H. (Harold), Witt, S. H. (Stephanie H.), Deuschle, M. (Michael), Pedersen, N. L. (Nancy L.), Hagg, S. (Sara), Sunyer, J. (Jordi), Franke, L. (Lude), Kaprio, J. (Jaakko), Ollikainen, M. (Miina), Moffitt, T. E. (Terrie E.), Tiemeier, H. (Henning), van IJzendoorn, M. H. (Marinus H.), Relton, C. (Caroline), Vrijheid, M. (Martine), Sebert, S. (Sylvain), Järvelin, M.-R. (Marjo-Riitta), Caspi, A. (Avshalom), Evans, K. L. (Kathryn L.), McIntosh, A. M. (Andrew M.), Bartels, M. (Meike), Boomsma, D. I. (Dorret, I), van Dongen, J. (Jenny), Hagenbeek, F. A. (Fiona A.), Suderman, M. (Matthew), Roetman, P. J. (Peter J.), Sugden, K. (Karen), Chiocchetti, A. G. (Andreas G.), Ismail, K. (Khadeeja), Mulder, R. H. (Rosa H.), Hafferty, J. D. (Jonathan D.), Adams, M. J. (Mark J.), Walker, R. M. (Rosie M.), Morris, S. W. (Stewart W.), Lahti, J. (Jari), Kupers, L. K. (Leanne K.), Escaramis, G. (Georgia), Alemany, S. (Silvia), Bonder, M. J. (Marc Jan), Meijer, M. (Mandy), Ip, H. F. (Hill F.), Jansen, R. (Rick), Baselmans, B. M. (Bart M. L.), Parmar, P. (Priyanka), Lowry, E. (Estelle), Streit, F. (Fabian), Sirignano, L. (Lea), Send, T. S. (Tabea S.), Frank, J. (Josef), Jylhava, J. (Juulia), Wang, Y. (Yunzhang), Mishra, P. P. (Pashupati Prasad), Colins, O. F. (Olivier F.), Corcoran, D. L. (David L.), Poulton, R. (Richie), Mill, J. (Jonathan), Hannon, E. (Eilis), Arseneault, L. (Louise), Korhonen, T. (Tellervo), Vuoksimaa, E. (Eero), Felix, J. F. (Janine F.), Bakermans-Kranenburg, M. J. (Marian J.), Campbell, A. (Archie), Czamara, D. (Darina), Binder, E. (Elisabeth), Corpeleijn, E. (Eva), Gonzalez, J. R. (Juan R.), Grazuleviciene, R. (Regina), Gutzkow, K. B. (Kristine B.), Evandt, J. (Jorunn), Vafeiadi, M. (Marina), Klein, M. (Marieke), van der Meer, D. (Dennis), Ligthart, L. (Lannie), Kluft, C. (Cornelis), Davies, G. E. (Gareth E.), Hakulinen, C. (Christian), Keltikangas-Jarvinen, L. (Liisa), Franke, B. (Barbara), Freitag, C. M. (Christine M.), Konrad, K. (Kerstin), Hervas, A. (Amaia), Fernandez-Rivas, A. (Aranzazu), Vetro, A. (Agnes), Raitakari, O. (Olli), Lehtimaki, T. (Terho), Vermeiren, R. (Robert), Strandberg, T. (Timo), Raikkonen, K. (Katri), Snieder, H. (Harold), Witt, S. H. (Stephanie H.), Deuschle, M. (Michael), Pedersen, N. L. (Nancy L.), Hagg, S. (Sara), Sunyer, J. (Jordi), Franke, L. (Lude), Kaprio, J. (Jaakko), Ollikainen, M. (Miina), Moffitt, T. E. (Terrie E.), Tiemeier, H. (Henning), van IJzendoorn, M. H. (Marinus H.), Relton, C. (Caroline), Vrijheid, M. (Martine), Sebert, S. (Sylvain), Järvelin, M.-R. (Marjo-Riitta), Caspi, A. (Avshalom), Evans, K. L. (Kathryn L.), McIntosh, A. M. (Andrew M.), Bartels, M. (Meike), and Boomsma, D. I. (Dorret, I)

Abstract

DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10−7; Bonferroni correction). In cord blood samples of 2425 children from five cohorts with aggression assessed at mean ages ranging from 4 to 7 years, 83% of these sites showed the same direction of association with childhood aggression (r = 0.74, p = 0.006) but no epigenome-wide significant sites were found. Top-sites (48 at a false discovery rate of 5% in the peripheral blood meta-analysis or in a combined meta-analysis of peripheral blood and cord blood) have been associated with chemical exposures, smoking, cognition, metabolic traits, and genetic variation (mQTLs). Three genes whose expression levels were associated with top-sites were previously linked to schizophrenia and general risk tolerance. At six CpGs, DNA methylation variation in blood mirrors variation in the brain. On average 44% (range = 3–82%) of the aggression–methylation association was explained by current and former smoking and BMI. These findings point at loci that are sensitive to chemical exposures with potential implications for neuronal functions. We hope these results to be a starting point for studies leading to applications as peripheral biomarkers and to reveal causal relationships with aggression and related traits.

Published
2021

4. Diagnostik und Therapie einer Inneren Laryngozele

Author

Koppen, T, Schade, G, Westermann, S, Bootz, F, and Send, T

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Als Laryngozele wird die hernienartige Aussackung des Ventriculus laryngis zwischen Plica vestibularis und Plica vocalis bezeichnet. Nur ca. 1/ 2.500.000 Patienten pro Jahr sind von der einseitigen oder selteneren (12,7%) zweiseitigen Variante betroffen. Man unterscheidet die angeborene[zum vollständigen Text gelangen Sie über die oben angegebene URL], Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte

Published
2019
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5. Management and outcome of epistaxis under direct oral anticoagulants: a comparison with warfarin

Author

Send, T, Bertlich, M, Horlbeck, F, Schafigh, D, Freytag, S, Eichhorn, KW, Graeff, I, Bootz, F, Jakob, M, Send, T, Bertlich, M, Horlbeck, F, Schafigh, D, Freytag, S, Eichhorn, KW, Graeff, I, Bootz, F, and Jakob, M

Abstract

BACKGROUND: Epistaxis is one of the more common reasons for emergency room visits. The main risk factor for epistaxis is anticoagulant therapy. Until recently, the main culprit was oral intake of a vitamin K antagonist, such as warfarin, which has a number of side effects. Even more recently, several direct oral anticoagulants, rivaroxaban and dabigatran, have been approved for use. We investigated the possible differences between treatment of epistaxis with direct oral anticoagulants and vitamin K antagonists. METHODS: We conducted a retrospective cohort study at a tertiary referral center in Germany. All patients who were admitted within a 1-year period were included. Patient files were used to obtain the information. RESULTS: Overall, 677 patients were included in our study. Of these, 159 had been treated with vitamin K antagonists and 49 with direct oral anticoagulants. There were no significant differences in terms of age (p = 0.592), sex (p = 0.372), vital signs, bloodwork, or location of bleeding (p = 0.372). Management of epistaxis between the groups was also comparable (p = 0.399), with similar hospital admission rates (37.1% vs 24.5%; p = 0.145) and duration of stay (3.5 ± 2.1 days vs 3.8 ± 3.3 days; p = 0.650). CONCLUSION: We found no evidence to suggest epistaxis is more severe or requires more invasive therapy in patients given direct oral anticoagulants. A significant proportion of patients on vitamin K antagonists were not within the target range for international normalized ratio, highlighting one of the main issues with oral anticoagulation by vitamin K antagonists.

Published
2019

6. Reconstruction of the skull base in spontaneous rhinoliquorrhea

Author

Jakob, M, Bertlich, M, Eichhorn, KW, Thudium, M, Bootz, F, Send, T, Jakob, M, Bertlich, M, Eichhorn, KW, Thudium, M, Bootz, F, and Send, T

Abstract

Objective/Hypothesis: Spontaneous rhinoliquorrhea often occurs due to defects of the skull base. It is often misinterpreted as rhinitis and is surgically the most difficult rhinoliquorrhea entity to close.Methods: We conducted a retrospective chart analysis of patients that were diagnosed with spontaneous rhinoliquorrhea at the University Hospital Bonn between 2001 and 2017.Results: Overall, twelve patients were included in this study. On average, the time between occurrence of nasal discharge and diagnoses of rhinoliquorrhea was 123 days. In ten patients, the localization of the skull base defect could be localized by computed tomography or MRI cisternography. Ten patients underwent surgery, of which 9 remained recurrence free. One patient underwent revision surgery and from thereon was recurrence free.Conclusion: Spontaneous rhinoliquorrhea still remains a diagnostic and therapeutic challenge. Whenever persistent watery nasal discharge appears in a patient, rhinoliquorrhea must be considered. Endoscopic surgical reconstruction of the skull base is the therapeutic gold standard and should be attempted as soon as the diagnosis is secured., Hypothese: Rhinoliqurrhoe tritt häufig als Folge von spontanen Schädelbasisläsionen auf; diese Form der Rhinoliqurrhoe ist die am schwierigsten zu beherrschende.Methoden: Wir haben eine retrospektive Analyse aller Patienten durchgeführt, welche mit der Diagnose einer spontanen Rhinoliquorrhoe im Uniklinikum Bonn behandelt wurden.Ergebnisse: Insgesamt wurden zwölf Patienten in dieser Studie eingeschlossen. Im Mittel betrug die Zeit zwischen dem ersten Auftreten einer wässerigen Rhinorrhoe und der Diagnose einer spontanen Rhinoliqurrhoe 123 Tage. In zehn dieser Patienten konnte der Defekt mittel Computertomographie oder MR-Zisternographie dargestellt werden. Zehn Patienten wurden aufgrund der spontanen Rhinoliqurrhoe operiert, von denen neun auch im weiteren Verlauf beschwerdefrei blieben. Ein Patient benötigt einen Revisionseingriff, war hernach jedoch ebenfalls ohne weitere Episoden von Rhinoliqurrhoe.Schlussfolgerung: Spontane Rhinoliqurrhoe ist nach wie vor sowohl diagnostisch wie therapeutisch eine Herausforderung. Bei jedem Patienten, der sich mit wässriger Rhinorrhoe vorstellt, muss eine spontane Rhinoliqurrhoe in Betracht gezogen werden. Die endoskopische Rekonstruktion der Schädelbasis ist bis heute der therapeutische Goldstandard und sollte bei Diagnosestellung geplant werden.

Published
2019

7. Sinunasale Malignome im Kopf-Halsbereich

Author

Eichhorn, K, Send, T, Bootz, F, and Jakob, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Sinunasale Malignome sind eine kleine und histologisch manigfaltige Gruppe der Malignome im Kopf- und Halsbereich. Methoden: Wir identifizierten und untersuchten 124 sinunasalen Malignome im Zeitraum von 2006 bis 2015 an der Bonner Universitätsklinik anhand der Akten und Pathologiebefunde[zum vollständigen Text gelangen Sie über die oben angegebene URL], 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2017
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8. Seltener cervicaler Weichgewebstumor – Desmoid-Tumore als Form des niedrigmalignen Sarkoms

Author

Send, T, Isselstein, JL, Van Bremen, T, and Bootz, F

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Desmoide sind seltene monoklonale Tumore (3-4 Fälle pro 1 Millionen pro Jahr) intermediärer Dignität, die in nahezu allen Organe des Körpers auftreten können. Typisch ist ein infiltratives Wachtum, schlechte Abgrenzbarkeit eine sehr hohe Lokalrezidivneigung jedoch[zum vollständigen Text gelangen Sie über die oben angegebene URL], 88. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2017
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11. Manifestationen von Amyloidose im Kopf-Hals-Bereich

Author

Bartmann, D, Albert, F, Bootz, F, and Send, T

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Beim Krankheitsbild der Amyloidose kommt es zur Ablagerung von unlöslichen Proteinaggregaten in multiplen Organsystemen, Gefäßen oder Nerven. Diese können hereditär oder erworben, lokalisiert oder systemisch auftreten und gehen mit unterschiedlichen klinischen Symptomen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 87. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2016
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12. Erstdiagnose der Sarkoidose im Kopf-Hals-Bereich

Author

Send, T, Bartmann, D, Pump, JB, Bootz, F, and Jakob, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Sarkoidose ist eine granulomatöse Multisystemerkrankung unklarer Ätiologie (>90% primärer Befall des Lungenparenchyms). Manifestationen im HNO-Bereich treten bei 10-15% der Patienten auf, am häufigsten als zervikale Lymphadenopathie. Die extrapulmonale[zum vollständigen Text gelangen Sie über die oben angegebene URL], 87. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2016
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13. Optogenetische Stimulation von Skelettmuskeln als Vorbereitung der Larynxstimulation – vom Licht zur Kontraktion

Author

Send, T, Brügmann, T, van Bremen, T, Bootz, F, Fleischmann, BK, and Sasse, P

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Steuerung genetisch modifizierter Muskelzellen mit Licht konnte bereits an Herzmuskelzellen gezeigt werden. Hier wird die Anwendung am Skelettmuskel untersucht. Grundlage bildet Kanalrhodopsin2 (ChR2), ein lichtgeschalteter Kationenkanal der Grünalge. Zellen die ChR2 exprimieren,[for full text, please go to the a.m. URL], 86. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2015
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14. Darstellung von Defekten der anterioren Schädelbasis bei spontaner Rhinoliquorrhoe

Author

Eichhorn, K, Send, T, Susanne, G, Bootz, F, and Jakob, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die spontan auftretende Rhinoliquorrhoe ohne erkennbare Ursache wie Trauma, Neoplasie oder vorausgegangene Operation ist selten (30 oder Pseudotumor cerebri. Der Nachweis der oft intermittierend auftretenden oder lageabhängigen Liquorrhoe durch eine konventionelle Bildgebung zur präoperativen Topodiagnostik der Fistel gelingt nicht immer. Methode: Von 2000 bis 2014 stellten sich in unserer Klinik insgesamt 14 Patienten mit einer spontanen Rhinoliquorrhoe vor. Die klinischen Daten und die Verläufe wurden retrospektiv aufgearbeitet. Ergebnisse: Eine spontane Rhinoliquorrhoe trat in unserem Patientengut 2mal so häufig bei Frauen (71,4%) wie bei Männern (28,6%) auf. Der Nachweis gelang mittels CT und MRT und in einigen Fällen (21,4%) erst mit einer intrathekalen Applikation von KM im MRT (MR-Zysternographie). In 2 Fällen lag zusätzlich eine Meningozele vor. In 11 (78,6%) konnte die Deckung endoskopisch erfolgen, in 2 Fällen wurde die OP nicht gewünscht und in einem Fall erfolgte die transfrontale Deckung mit einem Galea-Periost-Lappen in Kooperation mit der Neurochirurgie. Schlussfolgerungen: Bei einer spontanen Rhinoliquorrhoe ist der Nachweis einer Leckage (geringe Mengen/intermittierendes Auftreten) häufig erschwert. Der Goldstandart der Fisteldetektion sind HR-CT und MRT. Bei kleineren Fisteln von wenigen Millimetern kann eine MR/ CT-Zysternographie mit intrathekaler KM-Injektion (off-lable-use in der MR-Zysternographie) notwendig sein. Eine nuklearmedizinische Radionucleid-Zysternographie oder eine intrathekale Natrium-Fluoreszein Injektion stellen weitere Alternativen dar. Der Erstautor gibt keinen Interessenkonflikt an., GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; 11:Doc315; ISSN 1865-1038

Published
2015
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15. Optogenetische Stimulation von Skelettmuskeln – Larynxstimulation mit Licht am Mausmodell

Author

van Bremen, T, Brügmann, T, Send, T, Bootz, F, Fleischmann, BK, and Sasse, P

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die ein- oder beidseitige Parese des N. laryngeus recurrens ist eine häufige und schwerwiegende Komplikation nach Halsoperationen, malignen Prozessen oder neurologischen Erkrankungen. Aufgrund technischer Limitationen hat der elektrische Larynxschrittmacher noch keine dauerhafte Anwendung[for full text, please go to the a.m. URL], 86. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2015
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16. Seltene Differentialdiagnose einer therapieresistenten bakteriellen Pharyngitis

Author

Bartmann, D, Send, T, Herberhold, S, and Bootz, F

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Sexuell übertragbare Erkrankungen (STD) sind häufige Ursachen für Infektionen im Genitoanalbereich. Bei akuten oro-pharyngealen Infektionen spielen sie dagegen eine untergeordnete Rolle, sodass sie differentialdiagnostisch häufig nicht bedacht werden. Durch orogenitale[for full text, please go to the a.m. URL], 86. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2015
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22. Die kongenitale Encephalozele als mögliche Differenzialdiagnose einer Mittelohrraumforderung

Author

Send, T, Schröck, A, Gerstner, A, and Bootz, F

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Klinisch auffällige tympanale Raumforderungen sind häufige Indikationen für Ohroperationen. Intraoperativ kann die klinische Verdachtsdiagnose jedoch verschiedenste Tumorentitäten ergeben. Die kongenitale Encephalozele gehört zu den seltenen Differentialdiagnosen. Methoden: Wir demonstrieren den Fall einer multimorbiden 44-jährigen Patientin. Ergebnisse: Die Patientin stellte sich bei uns mit einer seit Jahren bestehenden Hörminderung des rechten Ohres vor. Es bestand keine Otorrhoe und kein Vertigo. Das Audiogramm ergab eine Schalleitungsschwerhörigkeit rechts, bei regelrechter Innenohrfunktion. Bei der ohrmikroskopischen Untersuchung stellte sich eine dem Trommelfell im hinteren oberen Quadranten anliegende Raumforderung dar. Sowohl das präoperativ durchgeführte MRT als auch das CT Felsenbein ergaben lediglich flüssigkeitsgefüllte Mastoidzellen. Mit der Verdachtsdiagnose eines Cholesteatoms wurde eine Mittelohrexploration in Intubationsnarkose durchgeführt. Intraoperativ ließ sich ein Cholesteatom ausschließen, vielmehr kam eine epitympanale polypöse Raumforderung zur Darstellung. Diese wurde biopsiert und die Operation bei unklarer Entität beendet. Die Histologie ergab intaktes Hirngewebe. Ein Trauma in der Vorgeschichte wurde verneint. In einer Folgeoperation wurde das prolabierte Hirngewebe über eine Mastoidektomie entfernt mit anschließender Otobasisrekonstruktion und Duraplastik. Schlussfolgerung: Kongenitale Encephalozelen sind selten. In unserem Fall handelt es sich am ehesten um einen kongenitalen Defekt im Tegmen tympani, denn andere bekannte Ursachen wie Trauma, Voroperationen oder Entzündungen lagen nicht vor. Typischerweise fand sich keine Liquorrhoe. Der Erstautor gibt keinen Interessenkonflikt an., GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; 9:Doc12; ISSN 1865-1038

Published
2013
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23. Metamizol als Standardanalgetikum? – Agranulozytose ein unterschätztes Risiko

Author

Send, T, Jakob, M, and Bootz, F

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Agranulozytose bei Metamizoltherapie (Novalgin®) ist ein bekanntes jedoch unterschätztes Risiko, trotzdem zeigt sich eine stetige Zunahme der Verordnungen als Standardanalgetikum in Deutschland. Die Inzidenz dieser lebensgefährlichen Nebenwirkung wird mit 1:5000 in der[for full text, please go to the a.m. URL], 83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2012
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24. Häufigkeit maligner Tumore als Zufallsbefund nach Tonsillektomie

Author

Send, T, Schröck, A, Bootz, F, and Jakob, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Zum Ausschluss okkulter Malignome wird das bei der Tonsillektomie entnommene Gewebe meist routinemäßig histologisch untersucht. Bei steigendem finanziellem Druck auf das Gesundheitssystem muss die Notwendigkeit von Routineuntersuchungen kritisch betrachtet werden. Methode:[for full text, please go to the a.m. URL], 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2010
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33. Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium.

Author

Yeung E, Biedrzycki RJ, Gómez Herrera LC, Issarapu P, Dou J, Marques IF, Mansuri SR, Page CM, Harbs J, Khodasevich D, Poisel E, Niu Z, Allard C, Casey E, Berstein FM, Mancano G, Elliott HR, Richmond R, He Y, Ronkainen J, Sebert S, Bell EM, Sharp G, Mumford SL, Schisterman EF, Chandak GR, Fall CHD, Sahariah SA, Silver MJ, Prentice AM, Bouchard L, Domellof M, West C, Holland N, Cardenas A, Eskenazi B, Zillich L, Witt SH, Send T, Breton C, Bakulski KM, Fallin MD, Schmidt RJ, Stein DJ, Zar HJ, Jaddoe VWV, Wright J, Grazuleviciene R, Gutzkow KB, Sunyer J, Huels A, Vrijheid M, Harlid S, London S, Hivert MF, Felix J, Bustamante M, and Guan W

Subjects
Humans, Female, Infant, Newborn, Child, Adult, Male, Child, Preschool, CpG Islands genetics, Pregnancy, DNA Methylation genetics, Maternal Age
Abstract

Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals. We meta-analyzed epigenome-wide associations of parental age with offspring blood DNAm of over 9500 newborns and 2000 children (5-10 years old) from the Pregnancy and Childhood Epigenetics consortium. In newborns, we identified 33 CpG sites in 13 loci with DNAm associated with maternal age (P FDR  < 0.05). Eight of these CpGs were located near/in the MTNR1B gene, coding for a melatonin receptor. Regional analysis identified them together as a differentially methylated region consisting of 9 CpGs in/near MTNR1B, at which higher DNAm was associated with greater maternal age (P FDR  = 6.92 × 10 -8 ) in newborns. In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant (p < 0.05) and retained the same positive direction, suggesting persistence of associations. Maternal age was also positively associated with higher DNA methylation at three CpGs in RTEL1-TNFRSF6B at birth (P FDR  < 0.05) and nominally in childhood (p < 0.0001). Of the remaining 10 CpGs also persistent in childhood, methylation at cg26709300 in YPEL3/BOLA2B in external data was associated with expression of ITGAL, an immune regulator. While further study is needed to establish causality, particularly due to the small effect sizes observed, our results potentially support offspring DNAm as a mechanism underlying associations of maternal age with child health., (© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)

Published
2024
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34. A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation.

Author

Li S, Spitz N, Ghantous A, Abrishamcar S, Reimann B, Marques I, Silver MJ, Aguilar-Lacasaña S, Kitaba N, Rezwan FI, Röder S, Sirignano L, Tuhkanen J, Mancano G, Sharp GC, Metayer C, Morimoto L, Stein DJ, Zar HJ, Alfano R, Nawrot T, Wang C, Kajantie E, Keikkala E, Mustaniemi S, Ronkainen J, Sebert S, Silva W, Vääräsmäki M, Jaddoe VWV, Bernstein RM, Prentice AM, Cosin-Tomas M, Dwyer T, Håberg SE, Herceg Z, Magnus MC, Munthe-Kaas MC, Page CM, Völker M, Gilles M, Send T, Witt S, Zillich L, Gagliardi L, Richiardi L, Czamara D, Räikkönen K, Chatzi L, Vafeiadi M, Arshad SH, Ewart S, Plusquin M, Felix JF, Moore SE, Vrijheid M, Holloway JW, Karmaus W, Herberth G, Zenclussen A, Streit F, Lahti J, Hüls A, Hoang TT, London SJ, and Wiemels JL

Subjects
Child, Female, Humans, Infant, Newborn, Pregnancy, Epigenesis, Genetic, Epigenomics, Birth Order, DNA Methylation
Abstract

Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends., (© 2024. The Author(s).)

Published
2024
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35. Alveolar Echinococcosis of the Parotid Gland-An Ultra Rare Location Reported from Western Europe.

Author

Koppen T, Barth TFE, Eichhorn KW, Gabrielpillai J, Kader R, Bootz F, and Send T

Abstract

(1) Background: Alveolar echinococcosis (AE) is restricted to the northern hemisphere with high endemic regions in Central Europe, North and Central Asia as well as Western China. The larval stage of Echinococcus multilocularis (E. multilocularis) causes AE with tumor-like growth. Humans are accidental hosts. This report is on the first case of AE becoming clinically manifested in the parotic gland. (2) Case presentation: A 52-year-old male patient presented with progressive and painful swelling of the right parotid gland persisting for one year. We performed a partial parotidectomy. The histological examination and immunohistological staining revealed larval stage of E. multilocularis . (3) Conclusion: E. multilocularis is known to infect animals and humans coincidentally, and leads to AE. It is one of the most life-threatening zoonoses in Europe. It typically manifests in the liver (50-77%), with further spreading to other organs being a rare phenomenon. Echinococcosis should be considered in the differential diagnosis of lesions of the parotid gland in endemic areas, but AE has not been described so far in the parotid gland as the sole manifestation and, therefore, impedes the correct diagnosis. A complete resection should be the aim, however, preservation of the facial nerve and adjuvant albendazole therapy is mandatory.

Published
2021
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36. Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein.

Author

Gabrielpillai J, Salamat A, Schaefer C, Kania A, Lunatschek C, Eichhorn KW, Bootz F, and Send T

Abstract

Thrombosis is a serious complication of a hyaluronic acid-based filler injection. Little is known about the late-onset complications of fillers; therefore, an optimal complication management is necessary. In this case report, we describe a rare complication of thrombosis after a filler injection. A 35-year old woman was admitted to the emergency department, with swelling on her forehead in association with recurrent pain and light flashes in her right eye. Sonographic examination showed a thrombosis of the right frontal vein. The patient reported that a hyaluronic acid filler injection had been administered on the forehead 3 months ago. After several weeks of anticoagulation with heparin and apixaban, the symptoms persisted. The vein with thrombosis was ultimately resected under local anesthesia. Histological findings showed a chronic inflammatory reaction of the tissue to hyaluronic acid. Vascular complications may appear as late-onset complications even several months after the filler injection. Subcutaneous application of low molecular weight heparins is the therapy of first choice. If this treatment is not effective, resection of the thrombosis may be performed., (Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)

Published
2020
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37. Higher number of multidisciplinary tumor board meetings per case leads to improved clinical outcome.

Author

Freytag M, Herrlinger U, Hauser S, Bauernfeind FG, Gonzalez-Carmona MA, Landsberg J, Buermann J, Vatter H, Holderried T, Send T, Schumacher M, Koscielny A, Feldmann G, Heine M, Skowasch D, Schäfer N, Funke B, Neumann M, and Schmidt-Wolf IGH

Subjects
Adult, Aged, Aged, 80 and over, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local therapy, Neoplasms pathology, Neoplasms therapy, Prognosis, Retrospective Studies, Survival Rate, Young Adult, Interdisciplinary Communication, Neoplasm Recurrence, Local mortality, Neoplasms mortality, Patient Care Team organization & administration
Abstract

Background: This analysis aims at evaluating the impact of multidisciplinary tumor boards on clinical outcome of multiple tumor entities, the effect of the specific number of multidisciplinary tumor boards and potential differences between the tumor entities., Methods: By a matched-pair analysis we compared the response to treatment, overall survival, relapse or disease free survival and progression free survival of patients whose cases were discussed in a tumor board meeting with patients whose cases were not. It was performed with patients registered in the cancer registry of the University of Bonn and diagnosed between 2010 and 2016. After the matching process with a pool of 7262 patients a total of 454 patients with 66 different tumor types were included in this study., Results: First, patients with three or more multidisciplinary tumor board meetings in their history show a significantly better overall survival than patients with no tumor board meeting. Second, response to treatment, relapse free survival and time to progression were not found to be significantly different. Third, there was no significant difference for a specific tumor entity., Conclusion: This study revealed a positive impact of a higher number of multidisciplinary tumor boards on the clinical outcome. Also, our analysis hints towards a positive effect of multidisciplinary tumor boards on overall survival.

Published
2020
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38. Reconstruction of the skull base in spontaneous rhinoliquorrhea.

Author

Jakob M, Bertlich M, Eichhorn KW, Thudium M, Bootz F, and Send T

Abstract

Objective/Hypothesis: Spontaneous rhinoliquorrhea often occurs due to defects of the skull base. It is often misinterpreted as rhinitis and is surgically the most difficult rhinoliquorrhea entity to close. Methods: We conducted a retrospective chart analysis of patients that were diagnosed with spontaneous rhinoliquorrhea at the University Hospital Bonn between 2001 and 2017. Results: Overall, twelve patients were included in this study. On average, the time between occurrence of nasal discharge and diagnoses of rhinoliquorrhea was 123 days. In ten patients, the localization of the skull base defect could be localized by computed tomography or MRI cisternography. Ten patients underwent surgery, of which 9 remained recurrence free. One patient underwent revision surgery and from thereon was recurrence free. Conclusion: Spontaneous rhinoliquorrhea still remains a diagnostic and therapeutic challenge. Whenever persistent watery nasal discharge appears in a patient, rhinoliquorrhea must be considered. Endoscopic surgical reconstruction of the skull base is the therapeutic gold standard and should be attempted as soon as the diagnosis is secured., Competing Interests: The authors declare that they have no competing interests.

Published
2019
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39. Optogenetic control of contractile function in skeletal muscle.

Author

Bruegmann T, van Bremen T, Vogt CC, Send T, Fleischmann BK, and Sasse P

Subjects
Animals, Channelrhodopsins, Dependovirus genetics, Electric Stimulation, Laryngeal Muscles pathology, Membrane Potentials, Mice, Mice, Transgenic, Muscle Fibers, Skeletal pathology, Muscle, Skeletal pathology, Laryngeal Muscles physiology, Light, Muscle Contraction, Muscle Fibers, Skeletal physiology, Muscle, Skeletal physiology, Optogenetics methods, Vocal Cords
Abstract

Optogenetic stimulation allows activation of cells with high spatial and temporal precision. Here we show direct optogenetic stimulation of skeletal muscle from transgenic mice expressing the light-sensitive channel Channelrhodopsin-2 (ChR2). Largest tetanic contractions are observed with 5-ms light pulses at 30 Hz, resulting in 84% of the maximal force induced by electrical stimulation. We demonstrate the utility of this approach by selectively stimulating with a light guide individual intralaryngeal muscles in explanted larynges from ChR2-transgenic mice, which enables selective opening and closing of the vocal cords. Furthermore, systemic injection of adeno-associated virus into wild-type mice provides sufficient ChR2 expression for optogenetic opening of the vocal cords. Thus, direct optogenetic stimulation of skeletal muscle generates large force and provides the distinct advantage of localized and cell-type-specific activation. This technology could be useful for therapeutic purposes, such as restoring the mobility of the vocal cords in patients suffering from laryngeal paralysis.

Published
2015
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