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5. Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study

Author

Okuyama, Nádia Calvo Martins, Cezar-dos-Santos, Fernando, Pereira, Érica Romão, Trugilo, Kleber Paiva, Cebinelli, Guilherme Cesar Martelossi, Sena, Michelle Mota, Pereira, Ana Paula Lombardi, Aranome, Adriano Martin Felis, Mangieri, Luis Fernando Lasaro, Ferreira, Rodolfo Sanches, Watanabe, Maria Angelica Ehara, and de Oliveira, Karen Brajão

Published
2018
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6. Immunotherapy in Acute Leukemias: Implications and Perspectives Using Wt1 Antigen.

Author

Cebinelli GC, DE Sousa Pereira N, Sena MM, DE Oliveira CE, Fujita TC, DA Rocha SP, DE Abreu Oliveira FJ, Marinello PC, and Watanabe MA

Subjects
Antigens, Neoplasm immunology, Apoptosis genetics, Apoptosis immunology, Cell Differentiation genetics, Cell Differentiation immunology, Cell Proliferation genetics, Dendritic Cells immunology, Humans, Leukemia genetics, Leukemia immunology, T-Lymphocytes, Cytotoxic immunology, WT1 Proteins immunology, WT1 Proteins therapeutic use, Antigens, Neoplasm genetics, Immunotherapy, Leukemia therapy, WT1 Proteins genetics
Abstract

The WT1 gene encodes a transcription factor involved in regulation of many cellular processes, including proliferation, differentiation, mRNA processing and apoptosis, besides acting as a transcription repressor of growth factors and their receptors' genes. This gene is expressed at high levels in several types of cancers, including acute leukemias. In this regard, many studies have identified WT1 protein as a tumor antigen, considered a target molecule for clinical application in human acute leukemias. Immunotherapy using WT1 antigen has been effective in stimulating immune responses against leukemic cells. Regarding adoptive immunotherapy, the use of dendritic cells (DCs) for the WT1-specific cytotoxic T cells generation proved to be efficient in the development and maintenance of immunologic cells. Therefore, these therapeutic methods, that provided enthusiasm for moving ahead, highlight several opportunities and challenges to be used in clinical practice for managing acute leukemias., (Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2016

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