93 results on '"Schwarzbold, Alexandre Vargas"'
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2. In-hospital mortality and severe outcomes after hospital discharge due to COVID-19: A prospective multicenter study from Brazil.
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Perazzo, Hugo, Cardoso, Sandra W, Ribeiro, Maria Pia D, Moreira, Rodrigo, Coelho, Lara E, Jalil, Emilia M, Japiassú, André Miguel, Gouvêa, Elias Pimentel, Nunes, Estevão Portela, Andrade, Hugo Boechat, Gouvêa, Luciano Barros, Ferreira, Marcel Treptow, Rodrigues, Pedro Mendes de Azambuja, Moreira, Ronaldo, Geraldo, Kim, Freitas, Lucilene, Pacheco, Vinicius V, João, Esau Custódio, Fuller, Trevon, Rocha, Verônica Diniz, Nunes, Ceuci de Lima Xavier, Souza, Tâmara Newman Lobato, Toscano, Ana Luiza Castro Conde, Schwarzbold, Alexandre Vargas, Noal, Helena Carolina, Pinto, Gustavo de Araujo, Lemos, Paula Macedo de Oliveira, Santos, Carla, Mello, Fernanda Carvalho de Queiroz, Veloso, Valdilea G, Grinsztejn, Beatriz, and RECOVER-SUS Brasil Group
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RECOVER-SUS Brasil Group ,ALT ,alanine aminotransferase ,AST ,aspartate aminotransferase BMI ,body mass index ,CI ,confidence interval ,COVID-19 ,COVID-19 ,Coronavirus disease 2019 ,CRP ,C-reactive protein ,ESR ,erythrocyte sedimentation rate ,ICU ,intensive care unit ,INR ,international normalized ratio ,IQR ,interquartile range ,In-hospital mortality ,NIV ,non-invasive ventilation ,PD ,person-days ,PY ,person-years ,Post-COVID-19 ,REDCap ,research electronic data capture ,SAPS-III ,simplified acute physiology score III ,SARS-CoV-2 ,severe acute respiratory syndrome coronavirus 2 ,SOFA ,sequential organ failure assessment ,VIF ,variance inflation factor ,VOC ,variant of concern ,WHO ,World Health Organization ,aHR ,adjusted-hazard ratio ,Clinical Research ,Good Health and Well Being - Abstract
BackgroundWe evaluated in-hospital mortality and outcomes incidence after hospital discharge due to COVID-19 in a Brazilian multicenter cohort.MethodsThis prospective multicenter study (RECOVER-SUS, NCT04807699) included COVID-19 patients hospitalized in public tertiary hospitals in Brazil from June 2020 to March 2021. Clinical assessment and blood samples were performed at hospital admission, with post-hospital discharge remote visits. Hospitalized participants were followed-up until March 31, 2021. The outcomes were in-hospital mortality and incidence of rehospitalization or death after hospital discharge. Kaplan-Meier curves and Cox proportional-hazard models were performed.Findings1589 participants [54.5% male, age=62 (IQR 50-70) years; BMI=28.4 (IQR,24.9-32.9) Kg/m² and 51.9% with diabetes] were included. A total of 429 individuals [27.0% (95%CI,24.8-29.2)] died during hospitalization (median time 14 (IQR,9-24) days). Older age [vs
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- 2022
3. Pipeline validation for the identification of antimicrobial-resistant genes in carbapenem-resistant Klebsiella pneumoniae
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Vieira, Andressa de Almeida, Piccoli, Bruna Candia, y Castro, Thaís Regina, Casarin, Bruna Campestrini, Tessele, Luiza Funck, Martins, Roberta Cristina Ruedas, Schwarzbold, Alexandre Vargas, and Trindade, Priscila de Arruda
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- 2023
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4. Potential and limitations of machine meta-learning (ensemble) methods for predicting COVID-19 mortality in a large inhospital Brazilian dataset
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de Paiva, Bruno Barbosa Miranda, Pereira, Polianna Delfino, de Andrade, Claudio Moisés Valiense, Gomes, Virginia Mara Reis, Souza-Silva, Maira Viana Rego, Martins, Karina Paula Medeiros Prado, Sales, Thaís Lorenna Souza, de Carvalho, Rafael Lima Rodrigues, Pires, Magda Carvalho, Ramos, Lucas Emanuel Ferreira, Silva, Rafael Tavares, de Freitas Martins Vieira, Alessandra, Nunes, Aline Gabrielle Sousa, de Oliveira Jorge, Alzira, de Oliveira Maurílio, Amanda, Scotton, Ana Luiza Bahia Alves, da Silva, Carla Thais Candida Alves, Cimini, Christiane Corrêa Rodrigues, Ponce, Daniela, Pereira, Elayne Crestani, Manenti, Euler Roberto Fernandes, Rodrigues, Fernanda d’Athayde, Anschau, Fernando, Botoni, Fernando Antônio, Bartolazzi, Frederico, Grizende, Genna Maira Santos, Noal, Helena Carolina, Duani, Helena, Gomes, Isabela Moraes, Costa, Jamille Hemétrio Salles Martins, di Sabatino Santos Guimarães, Júlia, Tupinambás, Julia Teixeira, Rugolo, Juliana Machado, Batista, Joanna d’Arc Lyra, de Alvarenga, Joice Coutinho, Chatkin, José Miguel, Ruschel, Karen Brasil, Zandoná, Liege Barella, Pinheiro, Lílian Santos, Menezes, Luanna Silva Monteiro, de Oliveira, Lucas Moyses Carvalho, Kopittke, Luciane, Assis, Luisa Argolo, Marques, Luiza Margoto, Raposo, Magda Cesar, Floriani, Maiara Anschau, Bicalho, Maria Aparecida Camargos, Nogueira, Matheus Carvalho Alves, de Oliveira, Neimy Ramos, Ziegelmann, Patricia Klarmann, Paraiso, Pedro Gibson, de Lima Martelli, Petrônio José, Senger, Roberta, Menezes, Rochele Mosmann, Francisco, Saionara Cristina, Araújo, Silvia Ferreira, Kurtz, Tatiana, Fereguetti, Tatiani Oliveira, de Oliveira, Thainara Conceição, Ribeiro, Yara Cristina Neves Marques Barbosa, Ramires, Yuri Carlotto, Lima, Maria Clara Pontello Barbosa, Carneiro, Marcelo, Bezerra, Adriana Falangola Benjamin, Schwarzbold, Alexandre Vargas, de Moura Costa, André Soares, Farace, Barbara Lopes, Silveira, Daniel Vitorio, de Almeida Cenci, Evelin Paola, Lucas, Fernanda Barbosa, Aranha, Fernando Graça, Bastos, Gisele Alsina Nader, Vietta, Giovanna Grunewald, Nascimento, Guilherme Fagundes, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, de Morais, Julia Drumond Parreiras, Moreira, Leila Beltrami, de Oliveira, Leonardo Seixas, de Deus Sousa, Lucas, de Souza Viana, Luciano, de Souza Cabral, Máderson Alvares, Ferreira, Maria Angélica Pires, de Godoy, Mariana Frizzo, de Figueiredo, Meire Pereira, Guimarães-Junior, Milton Henriques, de Paula de Sordi, Mônica Aparecida, da Cunha Severino Sampaio, Natália, Assaf, Pedro Ledic, Lutkmeier, Raquel, Valacio, Reginaldo Aparecido, Finger, Renan Goulart, de Freitas, Rufino, Guimarães, Silvana Mangeon Meirelles, Oliveira, Talita Fischer, Diniz, Thulio Henrique Oliveira, Gonçalves, Marcos André, and Marcolino, Milena Soriano
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- 2023
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5. Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians
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Delfino-Pereira, Polianna, Pires, Magda Carvalho, Gomes, Virginia Mara Reis, Nogueira, Matheus Carvalho Alves, Lima, Maria Clara Pontello Barbosa, Schwarzbold, Alexandre Vargas, Maurílio, Amanda de Oliveira, Scotton, Ana Luiza Bahia Alves, Costa, André Soares de Moura, Farace, Barbara Lopes, de Castro, Bruno Mateus, Cimini, Christiane Corrêa Rodrigues, Silveira, Daniel Vitório, Ponce, Daniela, Pereira, Elayne Crestani, Roesch, Eliane Würdig, Manenti, Euler Roberto Fernandes, Cenci, Evelin Paola de Almeida, dos Santos, Fernanda Costa, Anschau, Fernando, Aranha, Fernando Graça, Bartolazzi, Frederico, Nascimento, Guilherme Fagundes, Vianna, Heloisa Reniers, d'Arc Lyra Batista, Joanna, de Alvarenga, Joice Coutinho, Carvalho, Juliana da Silva Nogueira, Machado-Rugolo, Juliana, Ruschel, Karen Brasil, Menezes, Luanna Silva Monteiro, de Castro, Luís César, Nasi, Luiz Antônio, Floriani, Maiara Anschau, Souza, Maíra Dias, Souza-Silva, Maíra Viana Rego, Carneiro, Marcelo, Bicalho, Maria Aparecida Camargos, de Godoy, Mariana Frizzo, Guimarães-Júnior, Milton Henriques, Ziegelmann, Patricia Klarmann, Assaf, Pedro Ledic, Martelli, Petrônio José de Lima, Finger, Renan Goulart, Francisco, Saionara Cristina, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, de Oliveira, Thainara Conceição, Lage, Thalita Martins, Muller, Vanessa, Ramires, Yuri Carlotto, Ferrari, Teresa Cristina de Abreu, and Marcolino, Milena Soriano
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- 2023
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6. COVID-19 outcomes in people living with HIV: Peering through the waves
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Sales, Thaís Lorenna Souza, Souza-Silva, Maíra Viana Rego, Delfino-Pereira, Polianna, Neves, João Victor Baroni, Sacioto, Manuela Furtado, Assis, Vivian Costa Morais de, Duani, Helena, Oliveira, Neimy Ramos de, Sampaio, Natália da Cunha Severino, Ramos, Lucas Emanuel Ferreira, Schwarzbold, Alexandre Vargas, Jorge, Alzira de Oliveira, Scotton, Ana Luiza Bahia Alves, Castro, Bruno Mateus de, Silva, Carla Thais Cândida Alves da, Ramos, Carolina Marques, Anschau, Fernando, Botoni, Fernando Antonio, Grizende, Genna Maira Santos, Nascimento, Guilherme Fagundes, Ruschel, Karen Brasil, Menezes, Luanna Silva Monteiro, Castro, Luís César de, Nasi, Luiz Antônio, Carneiro, Marcelo, Godoy, Mariana Frizzo de, Nogueira, Matheus Carvalho Alves, Guimarães Júnior, Milton Henriques, Ziegelmann, Patricia Klarmann, Almeida, Rafaela Charão de, Francisco, Saionara Cristina, Silveira Neto, Sidney Teodoro, Araújo, Silvia Ferreira, Avelino-Silva, Thiago Junqueira, Aliberti, Márlon Juliano Romero, Pires, Magda Carvalho, Silva, Eduardo Sérgio da, and Marcolino, Milena Soriano
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- 2023
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7. Neurological manifestations by sex and age group in COVID-19 inhospital patients
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Pereira, Daniella Nunes, Bicalho, Maria Aparecida Camargos, Jorge, Alzira de Oliveira, Gomes, Angélica Gomides dos Reis, Schwarzbold, Alexandre Vargas, Araújo, Anna Luiza Homan, Cimini, Christiane Corrêa Rodrigues, Ponce, Daniela, Rios, Danyelle Romana Alves, Grizende, Genna Maira Santos, Manenti, Euler Roberto Fernandes, Anschau, Fernando, Aranha, Fernando Graça, Bartolazzi, Frederico, Batista, Joanna d'Arc Lyra, Tupinambás, Julia Teixeira, Ruschel, Karen Brasil, Ferreira, Maria Angélica Pires, Paraíso, Pedro Gibson, Araújo, Silvia Ferreira, Teixeira, Antonio Lucio, and Marcolino, Milena Soriano
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- 2022
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8. Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients
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Figueiredo, Flávio de Azevedo, Ramos, Lucas Emanuel Ferreira, Silva, Rafael Tavares, Ponce, Daniela, de Carvalho, Rafael Lima Rodrigues, Schwarzbold, Alexandre Vargas, Maurílio, Amanda de Oliveira, Scotton, Ana Luiza Bahia Alves, Garbini, Andresa Fontoura, Farace, Bárbara Lopes, Garcia, Bárbara Machado, da Silva, Carla Thais Cândida Alves, Cimini, Christiane Corrêa Rodrigues, de Carvalho, Cíntia Alcantara, Dias, Cristiane dos Santos, Silveira, Daniel Vitório, Manenti, Euler Roberto Fernandes, Cenci, Evelin Paola de Almeida, Anschau, Fernando, Aranha, Fernando Graça, de Aguiar, Filipe Carrilho, Bartolazzi, Frederico, Vietta, Giovanna Grunewald, Nascimento, Guilherme Fagundes, Noal, Helena Carolina, Duani, Helena, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, de Alvarenga, Joice Coutinho, Chatkin, José Miguel, de Morais, Júlia Drumond Parreiras, Machado-Rugolo, Juliana, Ruschel, Karen Brasil, Martins, Karina Paula Medeiros Prado, Menezes, Luanna Silva Monteiro, Couto, Luciana Siuves Ferreira, de Castro, Luís César, Nasi, Luiz Antônio, Cabral, Máderson Alvares de Souza, Floriani, Maiara Anschau, Souza, Maíra Dias, Souza-Silva, Maira Viana Rego, Carneiro, Marcelo, de Godoy, Mariana Frizzo, Bicalho, Maria Aparecida Camargos, Lima, Maria Clara Pontello Barbosa, Aliberti, Márlon Juliano Romero, Nogueira, Matheus Carvalho Alves, Martins, Matheus Fernandes Lopes, Guimarães-Júnior, Milton Henriques, Sampaio, Natália da Cunha Severino, de Oliveira, Neimy Ramos, Ziegelmann, Patricia Klarmann, Andrade, Pedro Guido Soares, Assaf, Pedro Ledic, Martelli, Petrônio José de Lima, Delfino-Pereira, Polianna, Martins, Raphael Castro, Menezes, Rochele Mosmann, Francisco, Saionara Cristina, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, de Oliveira, Thainara Conceição, Sales, Thaís Lorenna Souza, Avelino-Silva, Thiago Junqueira, Ramires, Yuri Carlotto, Pires, Magda Carvalho, and Marcolino, Milena Soriano
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- 2022
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9. Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry
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Pereira, Daniella Nunes, Silveira, Leticia Ferreira Gontijo, Guimarães, Milena Maria Moreira, Polanczyk, Carísi Anne, Nunes, Aline Gabrielle Sousa, Costa, André Soares de Moura, Farace, Barbara Lopes, Cimini, Christiane Corrêa Rodrigues, Carvalho, Cíntia Alcantara de, Ponce, Daniela, Roesch, Eliane Würdig, Manenti, Euler Roberto Fernandes, Lucas, Fernanda Barbosa, Rodrigues, Fernanda d'Athayde, Anschau, Fernando, Aranha, Fernando Graça, Bartolazzi, Frederico, Vietta, Giovanna Grunewald, Nascimento, Guilherme Fagundes, Duani, Helena, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, Costa, Jamille Hemétrio Salles Martins, Batista, Joanna d'Arc Lyra, Alvarenga, Joice Coutinho de, Chatkin, José Miguel, Morais, Júlia Drumond Parreiras de, Machado-Rugolo, Juliana, Ruschel, Karen Brasil, Pinheiro, Lílian Santos, Menezes, Luanna Silva Monteiro, Couto, Luciana Siuves Ferreira, Kopittke, Luciane, Castro, Luís César de, Nasi, Luiz Antônio, Cabral, Máderson Alvares de Souza, Floriani, Maiara Anschau, Souza, Maíra Dias, Carneiro, Marcelo, Bicalho, Maria Aparecida Camargos, Godoy, Mariana Frizzo de, Nogueira, Matheus Carvalho Alves, Guimarães Júnior, Milton Henriques, Sampaio, Natália da Cunha Severino, Oliveira, Neimy Ramos de, Assaf, Pedro Ledic, Finger, Renan Goulart, Campos, Roberta Xavier, Menezes, Rochele Mosmann, Francisco, Saionara Cristina, Alvarenga, Samuel Penchel, Guimarães, Silvana Mangeon Mereilles, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, Diniz, Thulio Henrique Oliveira, Ramires, Yuri Carlotto, Cenci, Evelin Paola de Almeida, Oliveira, Thainara Conceição de, Schwarzbold, Alexandre Vargas, Ziegelmann, Patricia Klarmann, Pozza, Roberta, Carvalho, Caroline Scherer, Pires, Magda Carvalho, and Marcolino, Milena Soriano
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- 2022
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10. Clinical characteristics and outcomes in COVID-19 in kidney transplant recipients: a propensity score matched cohort study
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Delfino-Pereira, Polianna, primary, Ventura, Vanessa das Graças José, additional, Pires, Magda Carvalho, additional, Ponce, Daniela, additional, Carmo, Gabriel Assis Lopes do, additional, Carmo, Lilian Pires de Freitas do, additional, Paiva, Bruno Barbosa Miranda de, additional, Schwarzbold, Alexandre Vargas, additional, Gomes, Angélica Gomides dos Reis, additional, Castro, Bruno Mateus de, additional, Polanczyk, Carísi Anne, additional, Cimini, Christiane Corrêa Rodrigues, additional, Lima, Daniela Antunes de, additional, Sousa, Fabiano Carvalho de, additional, Bartolazzi, Frederico, additional, Vietta, Giovanna Grunewald, additional, Vianna, Heloisa Reniers, additional, Chatkin, José Miguel, additional, Ruschel, Karen Brasil, additional, Kopittke, Luciane, additional, Castro, Luís César de, additional, Carneiro, Marcelo, additional, Reis, Priscilla Pereira dos, additional, and Marcolino, Milena Soriano, additional
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- 2024
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11. Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry
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Schwarzbold, Alexandre Vargas, de Oliveira Maurílio, Amanda, de Barros, Ana Lara Rodrigues Monteiro, Scotton, Ana Luiza Bahia Alves, Rodríguez-Morales, Alfonso J., dos Reis, Anderson Lacerda, Moura Costa, André Soares, de Oliveira, Argenil José Assis, Farace, Bárbara Lopes, da Silva, Carla Thais Cândida Alves, Ramos, Carolina Marques, Cimini, Christiane Corrêa Rodrigues, de Carvalho, Cíntia Alcantara, Silveira, Daniel Vitório, Ponce, Daniela, Kroger, Emanuele Marianne Souza, Manenti, Euler Roberto Fernandes, Lucas, Fernanda Barbosa, Rodrigues, Fernanda d'Athayde, Anschau, Fernando, Botoni, Fernando Antonio, Bartolazzi, Frederico, Crestani, Gabriela Petry, Nascimento, Guilherme Fagundes, Noal, Helena Carolina, Duani, Helena, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, de Alvarenga, Joice Coutinho, de Morais, Júlia Drumond Parreiras, Rugolo, Juliana Machado, Franco, Lara Monalyza Gonçalves, Moreira, Leila Beltrami, de Oliveira, Leonardo Seixas, Pinheiro, Lílian Santos, Pacheco, Liliane Souto, Kopittke, Luciane, de Souza Viana, Luciano, de Moura, Luis Cesar Souto, Santos, Luisa Elem Almeida, de Souza Cabral, Máderson Alvares, Souza, Maíra Dias, Tofani, Marcela Gonçalves Trindade, da Silveira, Marconi Franco, de Melo Andrade, Marcus Vinicius, Ferreira, Maria Angélica Pires, Bicalho, Maria Aparecida Camargos, Martins, Maria Auxiliadora Parreiras, Lima, Maria Clara Pontello Barbosa, Borges, Mariana Balbinot, Canesso, Mariana de Braga Lima Carvalho, Nogueira, Matheus Carvalho Alves, de Figueiredo, Meire Pereira, Guimarães Junior, Milton Henriques, Almeida, Mychelle Stefany Santos, de Sordi, Mônica Aparecida de Paula, Sampaio, Natália da Cunha Severino, de Oliveira, Neimy Ramos, Vianna, Paulo Tarso Lima, Andrade, Pedro Guido Soares, Assaf, Pedro Ledic, Oliveira, Rafael Fusaro Aguiar, de Carvalho, Rafael Lima Rodrigues, de Almeida, Rafaela dos Santos Charão, Martins, Raphael Castro, Valacio, Reginaldo Aparecido, Cardoso, Ricardo Bertoglio, Coelho, Ricardo Braga, Pozza, Roberta, Mourato, Rodolfo Lucas Silva, Vieira, Rodrigo Costa Pereira, de Abreu, Roger Mendes, Silva, Rufino de Freitas, Francisco, Saionara Cristina, Guimarães, Silvana Mangeon Mereilles, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, de Vargas, Tatiana, Fereguetti, Tatiani Oliveira, Lage, Thalita Martins, Diniz, Thulio Henrique Oliveira, dos Santos, Veridiana Baldon, Marcolino, Milena S., Ziegelmann, Patricia K., Souza-Silva, Maira V.R., Nascimento, I.J.B., Oliveira, Luana M., Monteiro, Luanna S., Sales, Thaís L.S., Ruschel, Karen B., Martins, Karina P.M.P., Etges, Ana Paula B.S., Molina, Israel, and Polanczyk, Carisi A.
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- 2021
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12. Corrigendum: Assessment of risk scores to predict mortality of COVID-19 patients admitted to the intensive care unit
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Nogueira, Matheus Carvalho Alves, primary, Nobre, Vandack, additional, Pires, Magda Carvalho, additional, Ramos, Lucas Emanuel Ferreira, additional, Ribeiro, Yara Cristina Neves Marques Barbosa, additional, Aguiar, Rubia Laura Oliveira, additional, Vigil, Flavia Maria Borges, additional, Gomes, Virginia Mara Reis, additional, Santos, Camila de Oliveira, additional, Miranda, Davi Mesquita, additional, Durães, Pamela Andrea Alves, additional, Costa, Josiane Moreira da, additional, Schwarzbold, Alexandre Vargas, additional, Gomes, Angélica Gomides dos Reis, additional, Pessoa, Bruno Porto, additional, Matos, Carolina Cunha, additional, Cimini, Christiane Corrêa Rodrigues, additional, Carvalho, Cíntia Alcântara de, additional, Ponce, Daniela, additional, Manenti, Euler Roberto Fernandes, additional, Cenci, Evelin Paola de Almeida, additional, Anschau, Fernando, additional, Costa, Flávia Carvalho Cardoso, additional, Nascimento, Francine Janaina Magalhães, additional, Bartolazzi, Frederico, additional, Grizende, Genna Maira Santos, additional, Vianna, Heloisa Reniers, additional, Nepomuceno, Jomar Cristeli, additional, Ruschel, Karen Brasil, additional, Zandoná, Liege Barella, additional, Castro, Luís César de, additional, Souza, Maíra Dias, additional, Carneiro, Marcelo, additional, Bicalho, Maria Aparecida Camargos, additional, Vilaça, Mariana do Nascimento, additional, Bonardi, Naiara Patrícia Fagundes, additional, Oliveira, Neimy Ramos de, additional, Lutkmeier, Raquel, additional, Francisco, Saionara Cristina, additional, Araújo, Silvia Ferreira, additional, Delfino-Pereira, Polianna, additional, and Marcolino, Milena Soriano, additional
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- 2024
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13. Incidence of Respiratory Syncytial Virus–Associated Lower Respiratory Tract Illness in Infants in Low- and Middle-Income Regions During the Coronavirus Disease 2019 Pandemic
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Fry, Samantha, primary, Chokephaibulkit, Kulkanya, additional, Pallem, Sridevi, additional, Henry, Ouzama, additional, Pu, Yongjia, additional, Akawung, Agnes, additional, Kim, Joon Hyung, additional, Yanni, Emad, additional, Tullio, Antonella Nadia, additional, Aurpibul, Linda, additional, Lee, Christine Mui Fong, additional, Ceballos, Ana, additional, Zaman, Khalequ, additional, Abadía de Regalado, Ivonne, additional, Ahmed, Khatija, additional, Arias Fernandez, Diana Andrea, additional, Taher, Sri Wahyu, additional, Caccavo, Juliana, additional, Coutinho, Conrado Milani, additional, D’Andrea Nores, Ulises, additional, De León, Tirza, additional, D’Silva, Emily Christine, additional, De Bernardi, Mara, additional, Dieser, Pablo, additional, Falaschi, Andrea, additional, Flores Acosta, Clara del Carmen, additional, Gentile, Angela, additional, Teo, Ik Hui, additional, Kotze, Sheena, additional, López-Medina, Eduardo, additional, Luca, Ruben, additional, Lucion, Maria Florencia, additional, Mantaring, Jacinto Blas III V, additional, Marín, Bladimir, additional, Moelo, Malahleha, additional, Mussi-Pinhata, Marisa Márcia, additional, Pinto, Jorge, additional, Puthanakit, Thanyawee, additional, Reyes, Osvaldo, additional, Roa, Maria Fernanda, additional, Rodriguez Brieschke, María Teresa, additional, Rodriguez, Camilo Enrique, additional, Rodriguez Niño, Juan Nicolas, additional, Schwarzbold, Alexandre Vargas, additional, Sierra Garcia, Alexandra, additional, Sivapatham, Lavitha, additional, Soon, Ruey, additional, Tinoco, Juan Carlos, additional, Velásquez Penagos, Jesús Arnulfo, additional, and Dos Santos, Gaël, additional
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- 2023
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14. Assessment of risk scores to predict mortality of COVID-19 patients admitted to the intensive care unit.
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Alves Nogueira, Matheus Carvalho, Nobre, Vandack, Carvalho Pires, Magda, Ferreira Ramos, Lucas Emanuel, Marques Barbosa Ribeiro, Yara Cristina Neves, Oliveira Aguiar, Rubia Laura, Borges Vigil, Flavia Maria, Reis Gomes, Virginia Mara, de Oliveira Santos, Camila, Mesquita Miranda, Davi, Alves Durães, Pamela Andrea, Moreira da Costa, Josiane, Schwarzbold, Alexandre Vargas, dos Reis Gomes, Angélica Gomides, Porto Pessoa, Bruno, Cunha Matos, Carolina, Rodrigues Cimini, Christiane Corrêa, Alcântara de Carvalho, Cíntia, Ponce, Daniela, and Fernandes Manenti, Euler Roberto
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- 2024
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15. AVALIAÇÃO DA CONCORDÂNCIA ENTRE RT-QPCR E SEQUENCIAMENTO DE GENOMA TOTAL NA IDENTIFICAÇÃO DE VARIANTES DO SARS-COV-2
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Casarin, Bruna Campestrini, primary, Somavilla, Viviane Drescher, additional, Castro, Thais Regins Y, additional, Vieira, Andressa de Almeida, additional, Tessele, Luiza Funck, additional, Schwarzbold, Alexandre Vargas, additional, and Trindade, Priscila de Arruda, additional
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- 2023
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16. ANÁLISE DO ESQUEMA VACINAL EM PACIENTES INFECTADOS COM A LINHAGEM XBB NA REGIÃO CENTRAL DO RIO GRANDE DO SUL, BRASIL
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Piccoli, Bruna Candia, primary, Tessele, Luíza Funck, additional, Casarin, Bruna Campestrini, additional, Castro, Thais Regina y, additional, Seerig, Ana Paula, additional, Vieira, Andressa de Almeida, additional, Schwarzbold, Alexandre Vargas, additional, Santos, Vitor Telles, additional, and Trindade, Priscila de Arruda, additional
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- 2023
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17. MODULAÇÃO TRANSCRICIONAL DE GENES ASSOCIADOS AO SISTEMA ANTIOXIDANTE EM PACIENTES COM COVID-19: IMPACTO POTENCIAL NO SISTEMA NERVOSO CENTRAL
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Piccoli, Bruna Candia, primary, Tessele, Luiza Funck, additional, Schwarzbold, Alexandre Vargas, additional, and Trindade, Priscila de Arruda, additional
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- 2023
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18. ANÁLISE RETROSPECTIVA DAS MUTAÇÕES NA ORF8 DO SARS-COV-2 NA REGIÃO CENTRAL DO RIO GRANDE DO SUL, BRASIL: IMPLICAÇÕES PARA O PROGNÓSTICO DA COVID-19
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Tessele, Luíza Funck, primary, Piccoli, Bruna Candia, additional, castro, Thais Regina y, additional, Casarin, Bruna Campestrini, additional, Vieira, Andressa de Almeida, additional, Santos, Vitor Telles dos, additional, Schwarzbold, Alexandre Vargas, additional, and Trindade, Priscila de Arruda, additional
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- 2023
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19. Dados de Vida Real sobre o Uso da Hidroxicloroquina ou da Cloroquina Combinadas ou Não à Azitromicina em Pacientes com Covid-19: Uma Análise Retrospectiva no Brasil
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Souza-Silva, Maíra Viana Rego, primary, Pereira, Daniella Nunes, additional, Pires, Magda Carvalho, additional, Vasconcelos, Isabela Muzzi, additional, Schwarzbold, Alexandre Vargas, additional, Vasconcelos, Diego Henrique de, additional, Pereira, Elayne Crestani, additional, Manenti, Euler Roberto Fernandes, additional, Costa, Felício Roberto, additional, Aguiar, Filipe Carrilho de, additional, Anschau, Fernando, additional, Bartolazzi, Frederico, additional, Nascimento, Guilherme Fagundes, additional, Vianna, Heloisa Reniers, additional, Batista, Joanna d’Arc Lyra, additional, Machado-Rugolo, Juliana, additional, Ruschel, Karen Brasil, additional, Ferreira, Maria Angélica Pires, additional, Oliveira, Leonardo Seixas de, additional, Menezes, Luanna Silva Monteiro, additional, Ziegelmann, Patricia Klarmann, additional, Tofani, Marcela Gonçalves Trindade, additional, Bicalho, Maria Aparecida Camargos, additional, Nogueira, Matheus Carvalho Alves, additional, Guimarães-Júnior, Milton Henriques, additional, Aguiar, Rúbia Laura Oliveira, additional, Rios, Danyelle Romana Alves, additional, Polanczyk, Carisi Anne, additional, and Marcolino, Milena Soriano, additional
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- 2023
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20. COVID-19 outcomes in people living with HIV: peering through the waves
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Saless, Thaís Lorenna Souza, primary, Souza-Silva, Maíra Viana Rego, additional, Delfino-Pereira, Polianna, additional, Neves, João Victor Baroni, additional, Sacioto, Manuela Furtado, additional, de Assis, Vivian Costa Morais, additional, Duani, Helena, additional, de Oliveira, Neimy Ramos, additional, Sampaio, Natália da Cunha Severino, additional, Ramos, Lucas Emanuel Ferreira, additional, Schwarzbold, Alexandre Vargas, additional, Jorge, Alzira de Oliveira, additional, Scotton, Ana Luiza Bahia Alves, additional, de Castro, Bruno Mateus, additional, da Silva, Carla Thais Cândida Alves, additional, Ramos, Carolina Marques, additional, Anschau, Fernando, additional, Botoni, Fernando Antonio, additional, Grizende, Genna Maira Santos, additional, Nascimento, Guilherme Fagundes, additional, Ruschel, Karen Brasil, additional, Menezes, Luanna Silva Monteiro, additional, de Castro, Luís César, additional, Nasi, Luiz Antônio, additional, Carneiro, Marcelo, additional, de Godoy, Mariana Frizzo, additional, Nogueira, Matheus Carvalho Alves, additional, Júnior, Milton Henriques Guimarães, additional, Ziegelmann, Patricia Klarmann, additional, de Almeida, Rafaela Charão, additional, Francisco, Saionara Cristina, additional, Neto, Sidney Teodoro Silveira, additional, Araújo, Silvia Ferreira, additional, Avelino-Silva, Thiago Junqueira, additional, Aliberti, Márlon Juliano Romero, additional, Pires, Magda Carvalho, additional, da Silva, Eduardo Sérgio, additional, and Marcolino, Milena Soriano, additional
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- 2023
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21. Assessment of risk scores to predict mortality of COVID-19 patients admitted to the intensive care unit
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Nogueira, Matheus Carvalho Alves, primary, Nobre, Vandack, additional, Pires, Magda Carvalho, additional, Ramos, Lucas Emanuel Ferreira, additional, Ribeiro, Yara Cristina Neves Marques Barbosa, additional, Aguiar, Rubia Laura Oliveira, additional, Vigil, Flavia Maria Borges, additional, Gomes, Virginia Mara Reis, additional, Santos, Camila de Oliveira, additional, Miranda, Davi Mesquita, additional, Durães, Pamela Andrea Alves, additional, Costa, Josiane Moreira da, additional, Schwarzbold, Alexandre Vargas, additional, Gomes, Angélica Gomides dos Reis, additional, Pessoa, Bruno Porto, additional, Matos, Carolina Cunha, additional, Cimini, Christiane Corrêa Rodrigues, additional, Carvalho, Cíntia Alcântara de, additional, Ponce, Daniela, additional, Manenti, Euler Roberto Fernandes, additional, Cenci, Evelin Paola de Almeida, additional, Anschau, Fernando, additional, Costa, Flávia Carvalho Cardoso, additional, Nascimento, Francine Janaina Magalhães, additional, Bartolazzi, Frederico, additional, Grizende, Genna Maira Santos, additional, Vianna, Heloisa Reniers, additional, Nepomuceno, Jomar Cristeli, additional, Ruschel, Karen Brasil, additional, Zandoná, Liege Barella, additional, Castro, Luís César de, additional, Souza, Maíra Dias, additional, Carneiro, Marcelo, additional, Bicalho, Maria Aparecida Camargos, additional, Vilaça, Mariana do Nascimento, additional, Bonardi, Naiara Patrícia Fagundes, additional, Oliveira, Neimy Ramos de, additional, Lutkmeier, Raquel, additional, Francisco, Saionara Cristina, additional, Araújo, Silvia Ferreira, additional, Delfino-Pereira, Polianna, additional, and Marcolino, Milena Soriano, additional
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- 2023
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22. Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19
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Barbosa, Hannah Cardoso, Martins, Maria Auxiliadora Parreiras, Jesus, Jordana Cristina de, Meira, Karina Cardoso, Passaglia, Luiz Guilherme, Sacioto, Manuela Furtado, Bezerra, Adriana Falangola Benjamin, Schwarzbold, Alexandre Vargas, Maurílio, Amanda de Oliveira, Farace, Barbara Lopes, Silva, Carla Thais Cândida Alves da, Cimini, Christiane Corrêa Rodrigues, Silveira, Daniel Vitorio, Carazai, Daniela do Reis, Ponce, Daniela, Costa, Emanuel Victor Alves, Manenti, Euler Roberto Fernandes, Cenci, Evelin Paola de Almeida, Bartolazzi, Frederico, Madeira, Glícia Cristina de Castro, Nascimento, Guilherme Fagundes, Velloso, Isabela Vasconcellos Pires, Batista, Joanna d’Arc Lyra, Morais, Júlia Drumond Parreiras de, Carvalho, Juliana da Silva Nogueira, Ruschel, Karen Brasil, Martins, Karina Paula Medeiros Prado, Zandoná, Liege Barella, Menezes, Luanna Silva Monteiro, Kopittke, Luciane, Castro, Luís César de, Nasi, Luiz Antônio, Floriani, Maiara Anschau, Souza, Maíra Dias, Carneiro, Marcelo, Bicalho, Maria Aparecida Camargos, Lima, Maria Clara Pontello Barbosa, Godoy, Mariana Frizzo de, Guimarães-Júnior, Milton Henriques, Mendes, Paulo Mascarenhas, Delfino-Pereira, Polianna, Ribeiro, Raquel Jaqueline Eder, Finger, Renan Goulart, Menezes, Rochele Mosmann, Francisco, Saionara Cristina, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, Oliveira, Thainara Conceição de, Polanczyk, Carisi Anne, and Marcolino, Milena Soriano
- Subjects
Respiração artificial ,Troponina ,Infecções por Coronavírus ,Mortalidade ,COVID-19 ,Artificial Respiration ,Mortality ,Coronavirus Infections ,Troponin - Abstract
Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p
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- 2023
23. Bordetella trematum infection: case report and review of previous cases
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y Castro, Thaís Regina, Martins, Roberta Cristina Ruedas, Dal Forno, Nara Lúcia Frasson, Santana, Luciana, Rossi, Flávia, Schwarzbold, Alexandre Vargas, Costa, Silvia Figueiredo, and Trindade, Priscila de Arruda
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- 2019
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24. Incipient Parallel Evolution of SARS-CoV-2 Deltacron Variant in South Brazil
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Sant’Anna, Fernando Hayashi, primary, Finger Andreis, Tiago, additional, Salvato, Richard Steiner, additional, Muterle Varela, Ana Paula, additional, Comerlato, Juliana, additional, Gregianini, Tatiana Schäffer, additional, Barcellos, Regina Bones, additional, de Souza Godinho, Fernanda Marques, additional, Resende, Paola Cristina, additional, da Luz Wallau, Gabriel, additional, y Castro, Thaís Regina, additional, Casarin, Bruna Campestrini, additional, de Almeida Vieira, Andressa, additional, Schwarzbold, Alexandre Vargas, additional, de Arruda Trindade, Priscila, additional, Tumioto Giannini, Gabriela Luchiari, additional, Freese, Luana, additional, Bristot, Giovana, additional, Brasil, Carolina Serpa, additional, de Oliveira Rocha, Bruna, additional, Martins, Paloma Bortolini, additional, de Oliveira, Francine Hehn, additional, van Oosterhout, Cock, additional, and Wendland, Eliana, additional
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- 2023
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25. Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19
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Barbosa, Hannah Cardoso, primary, Martins, Maria Auxiliadora Parreiras, additional, Jesus, Jordana Cristina de, additional, Meira, Karina Cardoso, additional, Passaglia, Luiz Guilherme, additional, Sacioto, Manuela Furtado, additional, Bezerra, Adriana Falangola Benjamin, additional, Schwarzbold, Alexandre Vargas, additional, Maurílio, Amanda de Oliveira, additional, Farace, Barbara Lopes, additional, Silva, Carla Thais Cândida Alves da, additional, Cimini, Christiane Corrêa Rodrigues, additional, Silveira, Daniel Vitorio, additional, Carazai, Daniela do Reis, additional, Ponce, Daniela, additional, Costa, Emanuel Victor Alves, additional, Manenti, Euler Roberto Fernandes, additional, Cenci, Evelin Paola de Almeida, additional, Bartolazzi, Frederico, additional, Madeira, Glícia Cristina de Castro, additional, Nascimento, Guilherme Fagundes, additional, Velloso, Isabela Vasconcellos Pires, additional, Batista, Joanna d’Arc Lyra, additional, Morais, Júlia Drumond Parreiras de, additional, Carvalho, Juliana da Silva Nogueira, additional, Ruschel, Karen Brasil, additional, Martins, Karina Paula Medeiros Prado, additional, Zandoná, Liege Barella, additional, Menezes, Luanna Silva Monteiro, additional, Kopittke, Luciane, additional, Castro, Luís César de, additional, Nasi, Luiz Antônio, additional, Floriani, Maiara Anschau, additional, Souza, Maíra Dias, additional, Carneiro, Marcelo, additional, Bicalho, Maria Aparecida Camargos, additional, Lima, Maria Clara Pontello Barbosa, additional, Godoy, Mariana Frizzo de, additional, Guimarães-Júnior, Milton Henriques, additional, Mendes, Paulo Mascarenhas, additional, Delfino-Pereira, Polianna, additional, Ribeiro, Raquel Jaqueline Eder, additional, Finger, Renan Goulart, additional, Menezes, Rochele Mosmann, additional, Francisco, Saionara Cristina, additional, Araújo, Silvia Ferreira, additional, Oliveira, Talita Fischer, additional, Oliveira, Thainara Conceição de, additional, Polanczyk, Carisi Anne, additional, and Marcolino, Milena Soriano, additional
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- 2023
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26. Raquianestesia em gestantes com COVID-19: revisão integrativa
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Yamada, Eduardo Jorge, primary, Petró, Gabriel de Sousa, additional, Rohden, Guiherme Barasuol, additional, Marques, Clandio Timm, additional, Schwarzbold, Alexandre Vargas, additional, and Backes, Dirce Stein, additional
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- 2023
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27. Spinal anesthesia in pregnant with COVID-19: integrative review
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Yamada, Eduardo Jorge, primary, Petró, Gabriel de Sousa, additional, Rohden, Guiherme Barasuol, additional, Marques, Clandio Timm, additional, Schwarzbold, Alexandre Vargas, additional, and Backes, Dirce Stein, additional
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- 2023
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28. Construcción del dispositivo para la Irradiación Ultravioleta UV-C
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Weis, Guilherme Lopes, Baumhardt, Tadeu, Torres, Herculis Rolins, Schwarzbold, Alexandre Vargas, and Dorneles, Lucio Strazzabosco
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Disinfection ,Raios Ultravioleta ,Rayos ultravioleta ,Desinfección ,COVID-19 ,Ultraviolet rays ,Desinfecção - Abstract
Durante a pandemia de COVID-19, a redução na produção e distribuição de diversos equipamentos de proteção individual (EPI), em especial, as máscaras N95, emergiu a necessidade de desenvolver um dispositivo local para desinfecção destes EPI, utilizando-se a radiação ultravioleta C (UV-C), aumentando a segurança dos usuários em caso de reuso desses equipamentos. Para realizar essa tarefa, foi desenvolvido o sistema de irradiação UV-C e, seu projeto, distribuído para diversas instituições que manifestaram interesse. Assim, baseado nos princípios de funcionamento de um equipamento de radioterapia, o qual possui fontes de radiação, dispositivos de controles de dose acumulada, de taxa de dose, de tempo de exposição e de segurança. Em março de 2020, com o auxílio de uma equipe técnica e de pesquisa foi possível desenvolver esse dispositivo e oportunizar a desinfecção das máscaras N95 no caso de escassez, ainda, como diferencial este projeto conta com um sistema de controle de dose UV (mJ/cm2) em tempo real. No entanto, como o Hospital Universitário adquiriu EPI em quantidade suficiente para a sua demanda, a implantação deste dispositivo não fora necessária. Com o objetivo de viabilizar a construção desse dispositivo, este trabalho traz todas as informações necessárias para a sua replicação, possibilitando que o mesmo seja utilizado como ferramenta segura para aplicação de radiação ultravioleta em diversas áreas como Unidade de Tratamento Intensivo - UTI, Centro de Materiais e Esterilização – CME, etc. During the COVID-19 pandemic, the reduction in the production and distribution of various personal protective equipment (PPE), in particular, N95 masks, emerged the need to develop a local device for disinfection of these PPE, using ultraviolet C radiation (UV-C), increasing the safety of users in case of reuse of this equipment. To accomplish this task, the UV-C irradiation system was developed and its project distributed to several institutions that expressed interest. Thus, based on the operating principles of radiotherapy equipment, which has radiation sources, accumulated dose control devices, dose rate, exposure time and safety. In March 2020, with the help of a technical and research team, it was possible to develop this device and provide the opportunity to disinfect N95 masks in case of shortage, still, as a differential, this project has a UV dose control system (mJ/cm2) in real time. However, as the University Hospital acquired PPE in sufficient quantity for its demand, the implantation of this device was not necessary. In order to enable the construction of this device, this work brings all the information necessary for its replication, allowing it to be used as a safe tool for the application of ultraviolet radiation in several areas such as the Intensive Care Unit - ICU, Materials Sterilization Center – MSC, etc. Durante la pandemia de COVID-19, la reducción en la producción y distribución de diversos equipos de protección personal (EPP), en particular, máscaras N95, surgió la necesidad de desarrollar un dispositivo local para la desinfección de estos EPP, utilizando radiación ultravioleta C (UV -C), aumentando la seguridad de los usuarios en caso de reutilización de este equipo. Para cumplir con esta tarea, se desarrolló el sistema de irradiación UV-C y se distribuyó su proyecto a varias instituciones que expresaron interés. Así, en base a los principios de funcionamiento de los equipos de radioterapia, que cuenta con fuentes de radiación, dispositivos de control de dosis acumulada, tasa de dosis, tiempo de exposición y seguridad. En marzo de 2020, con la ayuda de un equipo técnico y de investigación, se logró desarrollar este dispositivo y brindar la oportunidad de desinfectar mascarillas N95 en caso de escasez, aún así, como diferencial, este proyecto cuenta con un sistema de control de dosis UV (mJ /cm2) en tiempo real. Sin embargo, como el Hospital Universitario adquirió EPI en cantidad suficiente para su demanda, no fue necesaria la implantación de este dispositivo. Con el fin de viabilizar la construcción de este dispositivo, este trabajo trae toda la información necesaria para su replicación, permitiendo que sea utilizado como una herramienta segura para la aplicación de radiación ultravioleta en varias áreas como la Unidad de Cuidados Intensivos - UCI, Centro de Materiales y Esterilización – CME, etc.
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- 2022
29. In-hospital mortality and severe outcomes after hospital discharge due to COVID-19: A prospective multicenter study from Brazil
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Perazzo, Hugo, primary, Cardoso, Sandra W., additional, Ribeiro, Maria Pia D., additional, Moreira, Rodrigo, additional, Coelho, Lara E., additional, Jalil, Emilia M., additional, Japiassú, André Miguel, additional, Gouvêa, Elias Pimentel, additional, Nunes, Estevão Portela, additional, Andrade, Hugo Boechat, additional, Gouvêa, Luciano Barros, additional, Ferreira, Marcel Treptow, additional, Rodrigues, Pedro Mendes de Azambuja, additional, Moreira, Ronaldo, additional, Geraldo, Kim, additional, Freitas, Lucilene, additional, Pacheco, Vinicius V., additional, João, Esau Custódio, additional, Fuller, Trevon, additional, Rocha, Verônica Diniz, additional, Nunes, Ceuci de Lima Xavier, additional, Souza, Tâmara Newman Lobato, additional, Toscano, Ana Luiza Castro Conde, additional, Schwarzbold, Alexandre Vargas, additional, Noal, Helena Carolina, additional, Pinto, Gustavo de Araujo, additional, Lemos, Paula Macedo de Oliveira, additional, Santos, Carla, additional, Mello, Fernanda Carvalho de Queiroz, additional, Veloso, Valdilea G., additional, and Grinsztejn, Beatriz, additional
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- 2022
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30. Incipient Parallel Evolution of SARS-CoV-2 Deltacron Variant in South Brazil.
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Sant'Anna, Fernando Hayashi, Finger Andreis, Tiago, Salvato, Richard Steiner, Muterle Varela, Ana Paula, Comerlato, Juliana, Gregianini, Tatiana Schäffer, Barcellos, Regina Bones, de Souza Godinho, Fernanda Marques, Resende, Paola Cristina, da Luz Wallau, Gabriel, y Castro, Thaís Regina, Casarin, Bruna Campestrini, de Almeida Vieira, Andressa, Schwarzbold, Alexandre Vargas, de Arruda Trindade, Priscila, Tumioto Giannini, Gabriela Luchiari, Freese, Luana, Bristot, Giovana, Brasil, Carolina Serpa, and de Oliveira Rocha, Bruna
- Subjects
GENETIC recombination ,SARS-CoV-2 ,BIOLOGICAL evolution ,PESTE des petits ruminants - Abstract
With the coexistence of multiple lineages and increased international travel, recombination and gene flow are likely to become increasingly important in the adaptive evolution of SARS-CoV-2. These processes could result in genetic introgression and the incipient parallel evolution of multiple recombinant lineages. However, identifying recombinant lineages is challenging, and the true extent of recombinant evolution in SARS-CoV-2 may be underestimated. This study describes the first SARS-CoV-2 Deltacron recombinant case identified in Brazil. We demonstrate that the recombination breakpoint is at the beginning of the Spike gene. The 5′ genome portion (circa 22 kb) resembles the AY.101 (Delta), and the 3′ genome portion (circa 8 kb nucleotides) is most similar to the BA.1.1 (Omicron). Furthermore, evolutionary genomic analyses indicate that the new strain emerged after a single recombination event between lineages of diverse geographical locations in December 2021 in South Brazil. This Deltacron, AYBA-RS, is one of the dozens of recombinants described in 2022. The submission of only four sequences in the GISAID database suggests that this lineage had a minor epidemiological impact. However, the recent emergence of this and other Deltacron recombinant lineages (XD, XF, and XS) suggests that gene flow and recombination may play an increasingly important role in the COVID-19 pandemic. We explain the evolutionary and population genetic theory that supports this assertion, concluding that this stresses the need for continued genomic surveillance. This monitoring is vital for countries where multiple variants are present, as well as for countries that receive significant inbound international travel. [ABSTRACT FROM AUTHOR]
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- 2023
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31. Additional file 1 of Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients
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Figueiredo, Flávio de Azevedo, Ramos, Lucas Emanuel Ferreira, Silva, Rafael Tavares, Ponce, Daniela, de Carvalho, Rafael Lima Rodrigues, Schwarzbold, Alexandre Vargas, Maurílio, Amanda de Oliveira, Scotton, Ana Luiza Bahia Alves, Garbini, Andresa Fontoura, Farace, Bárbara Lopes, Garcia, Bárbara Machado, da Silva, Carla Thais Cândida Alves, Cimini, Christiane Corrêa Rodrigues, de Carvalho, Cíntia Alcantara, Dias, Cristiane dos Santos, Silveira, Daniel Vitório, Manenti, Euler Roberto Fernandes, Cenci, Evelin Paola de Almeida, Anschau, Fernando, Aranha, Fernando Graça, de Aguiar, Filipe Carrilho, Bartolazzi, Frederico, Vietta, Giovanna Grunewald, Nascimento, Guilherme Fagundes, Noal, Helena Carolina, Duani, Helena, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, de Alvarenga, Joice Coutinho, Chatkin, José Miguel, de Morais, Júlia Drumond Parreiras, Machado-Rugolo, Juliana, Ruschel, Karen Brasil, Martins, Karina Paula Medeiros Prado, Menezes, Luanna Silva Monteiro, Couto, Luciana Siuves Ferreira, de Castro, Luís César, Nasi, Luiz Antônio, Cabral, Máderson Alvares de Souza, Floriani, Maiara Anschau, Souza, Maíra Dias, Souza-Silva, Maira Viana Rego, Carneiro, Marcelo, de Godoy, Mariana Frizzo, Bicalho, Maria Aparecida Camargos, Lima, Maria Clara Pontello Barbosa, Aliberti, Márlon Juliano Romero, Nogueira, Matheus Carvalho Alves, Martins, Matheus Fernandes Lopes, Guimarães-Júnior, Milton Henriques, Sampaio, Natália da Cunha Severino, de Oliveira, Neimy Ramos, Ziegelmann, Patricia Klarmann, Andrade, Pedro Guido Soares, Assaf, Pedro Ledic, Martelli, Petrônio José de Lima, Delfino-Pereira, Polianna, Martins, Raphael Castro, Menezes, Rochele Mosmann, Francisco, Saionara Cristina, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, de Oliveira, Thainara Conceição, Sales, Thaís Lorenna Souza, Avelino-Silva, Thiago Junqueira, Ramires, Yuri Carlotto, Pires, Magda Carvalho, and Marcolino, Milena Soriano
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Additional file 1: Table S1. TRIPOD checklist for transparent reporting on a multivariable prognostic model.
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- 2022
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32. Additional file 4 of Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients
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Figueiredo, Flávio de Azevedo, Ramos, Lucas Emanuel Ferreira, Silva, Rafael Tavares, Ponce, Daniela, de Carvalho, Rafael Lima Rodrigues, Schwarzbold, Alexandre Vargas, Maurílio, Amanda de Oliveira, Scotton, Ana Luiza Bahia Alves, Garbini, Andresa Fontoura, Farace, Bárbara Lopes, Garcia, Bárbara Machado, da Silva, Carla Thais Cândida Alves, Cimini, Christiane Corrêa Rodrigues, de Carvalho, Cíntia Alcantara, Dias, Cristiane dos Santos, Silveira, Daniel Vitório, Manenti, Euler Roberto Fernandes, Cenci, Evelin Paola de Almeida, Anschau, Fernando, Aranha, Fernando Graça, de Aguiar, Filipe Carrilho, Bartolazzi, Frederico, Vietta, Giovanna Grunewald, Nascimento, Guilherme Fagundes, Noal, Helena Carolina, Duani, Helena, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, de Alvarenga, Joice Coutinho, Chatkin, José Miguel, de Morais, Júlia Drumond Parreiras, Machado-Rugolo, Juliana, Ruschel, Karen Brasil, Martins, Karina Paula Medeiros Prado, Menezes, Luanna Silva Monteiro, Couto, Luciana Siuves Ferreira, de Castro, Luís César, Nasi, Luiz Antônio, Cabral, Máderson Alvares de Souza, Floriani, Maiara Anschau, Souza, Maíra Dias, Souza-Silva, Maira Viana Rego, Carneiro, Marcelo, de Godoy, Mariana Frizzo, Bicalho, Maria Aparecida Camargos, Lima, Maria Clara Pontello Barbosa, Aliberti, Márlon Juliano Romero, Nogueira, Matheus Carvalho Alves, Martins, Matheus Fernandes Lopes, Guimarães-Júnior, Milton Henriques, Sampaio, Natália da Cunha Severino, de Oliveira, Neimy Ramos, Ziegelmann, Patricia Klarmann, Andrade, Pedro Guido Soares, Assaf, Pedro Ledic, Martelli, Petrônio José de Lima, Delfino-Pereira, Polianna, Martins, Raphael Castro, Menezes, Rochele Mosmann, Francisco, Saionara Cristina, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, de Oliveira, Thainara Conceição, Sales, Thaís Lorenna Souza, Avelino-Silva, Thiago Junqueira, Ramires, Yuri Carlotto, Pires, Magda Carvalho, and Marcolino, Milena Soriano
- Abstract
Additional file 4: Table S3. Assessment of potential predictors for the model development.
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- 2022
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33. Additional file 2 of Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients
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Figueiredo, Flávio de Azevedo, Ramos, Lucas Emanuel Ferreira, Silva, Rafael Tavares, Ponce, Daniela, de Carvalho, Rafael Lima Rodrigues, Schwarzbold, Alexandre Vargas, Maurílio, Amanda de Oliveira, Scotton, Ana Luiza Bahia Alves, Garbini, Andresa Fontoura, Farace, Bárbara Lopes, Garcia, Bárbara Machado, da Silva, Carla Thais Cândida Alves, Cimini, Christiane Corrêa Rodrigues, de Carvalho, Cíntia Alcantara, Dias, Cristiane dos Santos, Silveira, Daniel Vitório, Manenti, Euler Roberto Fernandes, Cenci, Evelin Paola de Almeida, Anschau, Fernando, Aranha, Fernando Graça, de Aguiar, Filipe Carrilho, Bartolazzi, Frederico, Vietta, Giovanna Grunewald, Nascimento, Guilherme Fagundes, Noal, Helena Carolina, Duani, Helena, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, de Alvarenga, Joice Coutinho, Chatkin, José Miguel, de Morais, Júlia Drumond Parreiras, Machado-Rugolo, Juliana, Ruschel, Karen Brasil, Martins, Karina Paula Medeiros Prado, Menezes, Luanna Silva Monteiro, Couto, Luciana Siuves Ferreira, de Castro, Luís César, Nasi, Luiz Antônio, Cabral, Máderson Alvares de Souza, Floriani, Maiara Anschau, Souza, Maíra Dias, Souza-Silva, Maira Viana Rego, Carneiro, Marcelo, de Godoy, Mariana Frizzo, Bicalho, Maria Aparecida Camargos, Lima, Maria Clara Pontello Barbosa, Aliberti, Márlon Juliano Romero, Nogueira, Matheus Carvalho Alves, Martins, Matheus Fernandes Lopes, Guimarães-Júnior, Milton Henriques, Sampaio, Natália da Cunha Severino, de Oliveira, Neimy Ramos, Ziegelmann, Patricia Klarmann, Andrade, Pedro Guido Soares, Assaf, Pedro Ledic, Martelli, Petrônio José de Lima, Delfino-Pereira, Polianna, Martins, Raphael Castro, Menezes, Rochele Mosmann, Francisco, Saionara Cristina, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, de Oliveira, Thainara Conceição, Sales, Thaís Lorenna Souza, Avelino-Silva, Thiago Junqueira, Ramires, Yuri Carlotto, Pires, Magda Carvalho, and Marcolino, Milena Soriano
- Abstract
Additional file 2: Table S2. L1 penalised shrunk coefficients for the MMCD score.
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- 2022
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34. Spinal anesthesia in pregnant women with COVID-19: integrative review.
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Jorge Yamada, Eduardo, de Sousa Petró, Gabriel, Rohden, Guiherme Barasuol, Marques, Clandio Timm, Schwarzbold, Alexandre Vargas, and Backes, Dirce Stein
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SPINAL anesthesia ,PREGNANT women ,PORTUGUESE people ,ANESTHESIOLOGISTS ,SYSTEMATIC reviews ,MEDLINE ,ENGLISH people ,GESTATIONAL age ,ONLINE information services ,HYPODERMIC needles ,COVID-19 - Abstract
Copyright of Minas Gerais Medical Journal / Revista Médica de Minas Gerais is the property of Associacao Medica de Minas Gerais and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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35. Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry
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Marcolino, Milena S., primary, Ziegelmann, Patricia K., additional, Souza-Silva, Maira V.R., additional, Nascimento, I.J.B., additional, Oliveira, Luana M., additional, Monteiro, Luanna S., additional, Sales, Thaís L.S., additional, Ruschel, Karen B., additional, Martins, Karina P.M.P., additional, Etges, Ana Paula B.S., additional, Molina, Israel, additional, Polanczyk, Carisi A., additional, Schwarzbold, Alexandre Vargas, additional, de Oliveira Maurílio, Amanda, additional, de Barros, Ana Lara Rodrigues Monteiro, additional, Scotton, Ana Luiza Bahia Alves, additional, Rodríguez-Morales, Alfonso J., additional, dos Reis, Anderson Lacerda, additional, Moura Costa, André Soares, additional, de Oliveira, Argenil José Assis, additional, Farace, Bárbara Lopes, additional, da Silva, Carla Thais Cândida Alves, additional, Ramos, Carolina Marques, additional, Cimini, Christiane Corrêa Rodrigues, additional, de Carvalho, Cíntia Alcantara, additional, Silveira, Daniel Vitório, additional, Ponce, Daniela, additional, Kroger, Emanuele Marianne Souza, additional, Manenti, Euler Roberto Fernandes, additional, Lucas, Fernanda Barbosa, additional, Rodrigues, Fernanda d'Athayde, additional, Anschau, Fernando, additional, Botoni, Fernando Antonio, additional, Bartolazzi, Frederico, additional, Crestani, Gabriela Petry, additional, Nascimento, Guilherme Fagundes, additional, Noal, Helena Carolina, additional, Duani, Helena, additional, Vianna, Heloisa Reniers, additional, Guimarães, Henrique Cerqueira, additional, de Alvarenga, Joice Coutinho, additional, de Morais, Júlia Drumond Parreiras, additional, Rugolo, Juliana Machado, additional, Franco, Lara Monalyza Gonçalves, additional, Moreira, Leila Beltrami, additional, de Oliveira, Leonardo Seixas, additional, Pinheiro, Lílian Santos, additional, Pacheco, Liliane Souto, additional, Kopittke, Luciane, additional, de Souza Viana, Luciano, additional, de Moura, Luis Cesar Souto, additional, Santos, Luisa Elem Almeida, additional, de Souza Cabral, Máderson Alvares, additional, Souza, Maíra Dias, additional, Tofani, Marcela Gonçalves Trindade, additional, da Silveira, Marconi Franco, additional, de Melo Andrade, Marcus Vinicius, additional, Ferreira, Maria Angélica Pires, additional, Bicalho, Maria Aparecida Camargos, additional, Martins, Maria Auxiliadora Parreiras, additional, Lima, Maria Clara Pontello Barbosa, additional, Borges, Mariana Balbinot, additional, Canesso, Mariana de Braga Lima Carvalho, additional, Nogueira, Matheus Carvalho Alves, additional, de Figueiredo, Meire Pereira, additional, Guimarães Junior, Milton Henriques, additional, Almeida, Mychelle Stefany Santos, additional, de Sordi, Mônica Aparecida de Paula, additional, Sampaio, Natália da Cunha Severino, additional, de Oliveira, Neimy Ramos, additional, Vianna, Paulo Tarso Lima, additional, Andrade, Pedro Guido Soares, additional, Assaf, Pedro Ledic, additional, Oliveira, Rafael Fusaro Aguiar, additional, de Carvalho, Rafael Lima Rodrigues, additional, de Almeida, Rafaela dos Santos Charão, additional, Martins, Raphael Castro, additional, Valacio, Reginaldo Aparecido, additional, Cardoso, Ricardo Bertoglio, additional, Coelho, Ricardo Braga, additional, Pozza, Roberta, additional, Mourato, Rodolfo Lucas Silva, additional, Vieira, Rodrigo Costa Pereira, additional, de Abreu, Roger Mendes, additional, Silva, Rufino de Freitas, additional, Francisco, Saionara Cristina, additional, Guimarães, Silvana Mangeon Mereilles, additional, Araújo, Silvia Ferreira, additional, Oliveira, Talita Fischer, additional, de Vargas, Tatiana, additional, Fereguetti, Tatiani Oliveira, additional, Lage, Thalita Martins, additional, Diniz, Thulio Henrique Oliveira, additional, and dos Santos, Veridiana Baldon, additional
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- 2021
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36. Vancomycin-resistant enterococcus faecium bacteremia in a tertiary care hospital : epidemiology, antimicrobial susceptibility, and outcome
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Rosa, Regis Goulart, Schwarzbold, Alexandre Vargas, Santos, Rodrigo Pires dos, Turra, Eduardo Eggers, Machado, Denise Pires, and Goldani, Luciano Zubaran
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Enterococos resistentes à vancomicina ,Bacteremia ,Infecção hospitalar ,Vancomicina - Abstract
Vancomycin-resistant Enterococcus faecium (VREF) has emerged as a relevant multidrug-resistant pathogen and potentially lethal etiology of health care associated infections worldwide. The objective of this retrospective cohort study was to assess factors associated with mortality in patients with VREF bacteremia in a major tertiary referral hospital in Southern Brazil. All documented cases of bacteremia identified betweenMay 2010 and July 2012 were evaluated. Cox regression was performed to determine whether the characteristics related to the host or antimicrobial treatment were associated with the all-cause 30-day mortality. In total, 35 patients with documented VREF bacteremia were identified during the study period. The median APACHE-II score of the study population was 26 (interquartile range: 10).The overall 30-day mortality was 65.7%. All VREF isolates were sensitive to linezolid, daptomycin, and quinupristin-dalfopristin. Linezolid was the only antimicrobial agent with in vitro activity against VREF that was administered to the cohort. After multivariate analysis, linezolid treatment (HR, 0.08; 95% CI, 0.02–0.27) and presence of acute kidney injury at the onset of bacteremia (HR, 4.01; 95% CI, 1.62–9.94) were independently associated with mortality. Presentation with acute kidney injury and lack of treatment with an effective antibiotic poses risk for mortality in patients withVREF bacteremia.
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- 2014
37. A fully validated microbiological assay for daptomycin injection and comparison to HPLC method
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Christ, Ana Paula, primary, Machado, Mariana Souto, additional, Ribas, Karla Giacomelli, additional, Schwarzbold, Alexandre Vargas, additional, Silva, Cristiane de Bona da, additional, and Adams, Andréa Inês Horn, additional
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- 2015
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38. Bacteremia por Enterococcus faecium resistente à vancomicina em hospital terciário : epidemiologia, susceptibilidade aos antimicrobianos e mortalidade
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Schwarzbold, Alexandre Vargas and Goldani, Luciano Zubaran
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Doenças transmissíveis ,Risk factors ,Epidemiology ,Susceptibility ,Enterococcus faecium ,Bacteriemia ,Mortalidade ,Resistência à vancomicina ,Bacteremia ,Mortality ,Epidemiologia ,Vancomycin-resistant Enterococcus ,Enterococcus - Abstract
Introdução: Enterococcus faecium resistente à vancomicina (EFRV) surgiu como um importante patógeno multirresistente e de etiologia potencialmente letal nas infecções associadas aos cuidados de saúde em todo o mundo. Objetivo: O objetivo deste estudo de coorte retrospectivo foi avaliar os fatores associados à mortalidade em pacientes com bacteremia causadas por EFRV em um grande hospital de referência terciária no sul do Brasil. Métodos: Foram avaliados todos os casos documentados de bacteremia identificados entre maio de 2010 e julho de 2012. Regressão de Cox foi realizada para determinar se as características relacionadas ao hospedeiro ou o tratamento antimicrobiano estavam associadas com a mortalidade por qualquer causa em 30 dias. No total, 35 pacientes documentados com bacteremia por EFRV foram identificados durante o período de estudo. Resultados: A mediana do escore APACHE-II da população do estudo foi 26 (IQR 10). A mortalidade global em 30 dias foi de 65,7%%. Todos isolados de EFRV eram sensíveis à linezolida, daptomicina e quinopristina - dalfopristina. A linezolida foi o único agente antimicrobiano com atividade in vitro contra EFRV que foi administrada à coorte. Após a análise multivariada, o tratamento com linezolida (HR 0,08, 95% CI, 0,02-0,27) e a presença de insuficiência renal aguda no início da bacteremia (HR 4,01, 95% CI, 1,62-9,94) foram associadas de forma independente com o desfecho principal. Conclusão: Apresentação com insuficiência renal aguda e ausência de tratamento com um antibiótico eficaz representa um risco de mortalidade em pacientes com bacteremia por EFRV. Background: Vancomycin-resistant Enterococcus faecium (VREF) has emerged as a relevant multidrug-resistant pathogen and potentially lethal etiology of health care-associated infections worldwide. Objective: The objective of this retrospective cohort study was to assess factors associated with mortality in patients with VREF bacteremia in a major tertiary referral hospital in southern Brazil. Methods: All documented cases of bacteremia identified between May 2010 and July 2012 were evaluated. Cox regression was performed to determine whether the characteristics related to the host or antimicrobial treatment were associated with the all-cause 30-day mortality. In total, 35 patients with documented VREF bacteremia were identified during the study period. Results: The median APACHE-II score of the study population was 26 (IQR 10). The overall 30-day mortality was 65.7%. All VREF isolates were sensitive to linezolid, daptomycin and quinopristin-dalfopristin. Linezolid was the only antimicrobial agent with in vitro activity against VREF that was administered to the cohort. After multivariate analysis, linezolid treatment (HR, 0.08; 95%CI, 0.02 – 0.27) and presence of acute kidney injury at the onset of bacteremia (HR, 4.01; 95%CI, 1.62 – 9.94) were independently associated with the main outcome. Conclusion: Presentation with acute kidney injury and lack of treatment with an effective antibiotic poses risk for mortality in patients with VREF bacteremia.
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- 2013
39. Modelagem de um escore de mielotoxicidade quimioterápica na predição de neutropenia febril em tumores hematológicos
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Schwarzbold, Alexandre Vargas and Goldani, Luciano Zubaran
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Hematological malignancies ,Previsões ,Neutropenia ,Risk model ,Febrile neutropenia ,Chemotherapy ,Quimioterapia ,Myelotoxicity score ,Prediction ,Toxicidade de medicamentos ,Neoplasias hematológicas - Abstract
A neutropenia induzida pela quimioterapia é o mais comum efeito adverso da quimioterapia sistêmica para o câncer e é frequentemente complicada por neutropenia febril (NF). O uso profilático de fatores de crescimento hematopoiéticos pode reduzir o risco, a severidade e a duração da NF. Na prática clínica atual, a decisão de administrar ao paciente profilaxia com fatores de crescimento é baseada principalmente no potencial mielotóxico dos esquemas de QT, mas riscos específicos dos regimes não são definidos. Em muitos estudos, a toxicidade da quimioterapia é analizada em termos de alta dosagem versus baixa dosagem, sem uma regra geral que considere os diferentes esquemas de QT em uma única escala. O objetivo desse estudo é validar uma classificação de toxicidade de um esquema de QT e avaliar sua utilidade em um modelo de predição de risco de neutropenia febril em pacientes com câncer hematológico no começo de um ciclo de quimioterapia. Foram avaliados prospectivamente duzentos e sessenta e oito pacientes e acompanhados durante 1053 ciclos de quimioterapia na Bélgica, entre 2001 e 2005. Informações relevantes foram coletadas no começo do primeiro ciclo e o número de dias de neutropenia febril foi contabilizado no acompanhamento dos pacientes [dicotomizada (sem neutropenia versus >= dia de NF)]. A relação entre o desfecho e as co-variáveis foi analisada usando a Equação de Estimativa Generalizada (GEE). Um regime de quimioterapia agressiva é o maior preditor de NF [razão de chances (OR) 5.2 (3.2-8.4)]. Os outros preditores independentes são: doença subjacente, o comprometimento de medula óssea, superfície corporal = 1 day of FN)]. Aggressive chemotherapy regimen is the major predictor of FN [odds ratio 5.2 (3.2 - 8.4)]. The other independent predictors are the underlying disease, an involvement of bone marrow, body surface
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- 2006
40. Indução de aderência intrabdominal por prótese de retícula de polipropileno : estudo experimental em ratos
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Gurski, Richard Ricachenevsky, Schirmer, Carlos Cauduro, Wagner, Jeverson, Berlim, Gustavo Levacov, Muller, Marcelo Figueiredo, Beck, Plauto Erasmo, Weidlich, Juliana, Teruchkin, Betina, Schwarzbold, Alexandre Vargas, Leite, Cristina Silveira Moraes, Tatsch, Mariana Franciosi, Saueressig, Mauricio Guidi, Edelweiss, Maria Isabel Albano, and Kruel, Cleber Dario Pinto
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Laparoscopia ,Hérnia ,Postoperative adhesions ,Laparoscopic surgery ,Virilha ,Groin hernia - Abstract
INTRODUÇÃO: A correção de hérnias na virilha através de um método videolaparoscópico transperitoneal está se tornando cada vez mais comum. Contudo, este método poderia levar a um aumento na incidência de formação de aderências. MATERIAIS E MÉTODOS: A incidência de aderências induzidas pela colocação de retícula e pela reperitonização foram observadas em 40 ratos Wistar adultos, machos, divididos aleatoriamente em quatro grupos com 10 ratos cada um (Grupo A = sem retícula, sem reperitonização; B = sem retícula, com reperitonização; C = com retícula, sem reperitonização; D = retícula e reperitonização). Após a abertura da cavidade abdominal, a fossa ilíaca foi identificada e fez-se uma abertura de aproximadamente 2 x 2 cm na parede parietal. Nos ratos em que uma prótese de polipropileno foi utilizada, uma retícula Marlex com 1,5 x 1,5 cm foi colocada sobre a abertura peritoneal. Nos outros animais, a reperitonização foi feita com sutura simples, utilizando-se fio de polipropileno monofilamentar 5.0 com uma agulha cardiovascular (atraumática). Os animais foram sacrificados 15 dias depois da operação. A análise macroscópica foi realizada por um investigador cego quanto ao grupo de origem dos animais. A análise estatística utilizou o teste exato de Fisher e o c2. Um P < 0,05 foi considerado significativo. RESULTADOS: As aderências foram significativamente mais comuns nos grupos nos quais a prótese foi utilizada (59% vs. 95%; P = 0,01), assim como nos grupos nos quais foi feita a reperitonização (58% vs. 100%; P = 0,03). CONCLUSÕES: Os resultados sugerem que a retícula de polipropileno e a reperitonização são fatores independentes entre si quanto à indução de formação de aderências. INTRODUCTION: The correction of groin hernias using a transperitoneal videolaparoscopic method with a polypropylene mesh is becoming increasingly common. This could lead to an increased incidence of adhesion formation. MATERIALS AND METHODS: The incidence of adhesions induced by mesh placement and by reperitonization was observed in 40 male adult Wistar rats, randomly allocated to four groups of 10 rats (Group A = no mesh, no reperitonization; B = no mesh, reperitonization; C = mesh, no reperitonization; D = mesh and reperitonization). After opening the abdominal cavity, the iliac fossa was identified and a peritoneal opening, measuring about 2 by 2 cm, was done on the parietal wall. In the rats in which a polypropylene prosthesis was used, a piece of Marlex mesh, measuring about 1.5 by 1.5 cm was placed on the peritoneal opening. A simple suture was performed in the animals submitted to reperitonization, using a 5.0 monofilamentar polypropylene thread on a cardiovascular (atraumatic) needle. The animals were killed 15 days after the operation. Macroscopic analysis was done by an investigator blinded to intervention group. Fisher’s exact test and the c2 test were used for statistical analysis of the results. A P < 0.05 was considered as significant. RESULTS: Adhesions were significantly more common in the groups in which the prosthesis was placed (59% vs. 95%; P = 0.01), as well as in the groups in which reperitonization was performed (58% vs. 100%; P = 0.03). CONCLUSIONS: The results suggest that polypropylene mesh placement and reperitonization are each independent factors that have a role in inducing the formation of adhesions.
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- 1998
41. Efficacy of multi-layered soft silicone foam dressing compared to transparent polyurethane film in heels pressure injury prevention: within person randomized clinical trial (Pressure Injury Prevention Trial − PIPT)
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Soares, Rhea Silvia de Avila, Lima, Suzinara Beatriz Soares de, Alves, Paulo Jorge Pereira, Lopes, Camila Mendonça de Moraes, Martins, Elenice Spagnolo Rodrigues, Padoin, Stela Maris de Mello, Magnago, Tania Solange Bosi de Souza, and Schwarzbold, Alexandre Vargas
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Pele ,Clinical trial ,Ensaio clínico ,Temperatura corporal ,Enfermagem ,Body temperature ,Lesão por pressão ,Nursing ,Pressure ulcer ,Skin ,CIENCIAS DA SAUDE::ENFERMAGEM [CNPQ] - Abstract
It is relevant to evaluate new technologies in PI prevention to substantiate a professional practice based on scientific evidences. The objective of this research is to evaluate the efficacy of multi-layered soft silicone foam dressing compared to transparent polyurethane film in heels pressure injury prevention, in patients hospitalized in intensive care unit (ICU) with high and very high risk. It was performed a within person randomized clinical trial, developed in a university hospital from south of Brazil, from July 21st 2017 to March 25th 2018. The sample consisted of successive entries of the patients that met the inclusion criteria, from daily visits the ICU for the recruitment of eligible patients, totalling 92 patients and 184 cutaneous sites. Randomization was performed for the heels: intervention group (multi-layered soft silicone foam dressing) and control group (transparent polyurethane film). After randomization and initial data collection (baseline), the intervention was performed according to each group. Data were analyzed by the program Statistical Package for Social Sciences version 21. In order to evaluate the primary outcome (PI development), the incidence and relative risk were calculated. For the variables of the skin microclimate on the first day (baseline) and the last (end), a Wilcoxon test was performed. To analyze the outcome variables between the groups with and without PI development, Student's t test or Mann-Whitney U test was performed. To verify the association between the qualitative independent variables and the development of LP, a Chi- Square or Fisher's exact test was performed. In order to analyze the correlation between the quantitative variables, Spearman's correlation was used. A level of statistical significance of 5% was used. The ethical aspects were observed according to precepts established in Resolution 466/2012 of the National Health Council. The PI incidence was 10.9%, with 8.7% in the intervention group and 13.0% in the control group. The difference in incidence between groups was not significant (p=0.333). The skin temperature of heels that developed LP as well as of heels in use of the transparent polyurethane film did not present significant difference between baseline and end. The factors associated with the PI development were age, length of stay in the study, length of hospital stay prior to ICU, edema and erythema. The study provides additional evidence to support the use of multi-layered soft silicone foam dressing in PI prevention. The relative risk was 0.67, thus those who used multi-layered soft silicone foam dressing had 33% lower risk of PI developing compared to patients using transparent polyurethane film. É relevante avaliar novas tecnologias na prevenção das lesões por pressão para fundamentar uma práxis profissional baseada em evidências científicas. O objetivo desta pesquisa é avaliar a eficácia do uso da espuma multicamadas de poliuretano com silicone (EMPS) comparada ao filme transparente de poliuretano (FTP) na prevenção de LP em pacientes hospitalizados em unidade de tratamento intensivo (UTI) com alto risco ou risco muito alto. Trata-se de um ensaio clínico randomizado autocontrolado, desenvolvido em um hospital universitário do sul do Brasil, de julho de 2017 a março de 2018. A amostra foi constituída por entradas sucessivas dos pacientes que atenderam aos critérios de inclusão, a partir de visitas diárias a UTI para recrutamento dos pacientes elegíveis, totalizando 92 pacientes e 184 sítios cutâneos. A randomização foi realizada para os calcâneos: grupo intervenção (EMPS) e grupo controle (FTP). Após a randomização e coleta dos dados iniciais (baseline) foi realizada a intervenção de acordo com cada grupo. Os dados foram analisados pelo programa Statistical Package for Social Sciences versão 21. Para avaliar o desfecho primário (desenvolvimento de LP), foi calculada a incidência e o risco relativo. Para as variáveis do microclima da pele, foi realizado teste de Wilcoxon. Para analisar as variáveis de desfecho entre os grupos com e sem desenvolvimento de LP, realizou-se teste t de Student ou U de Mann-Whitney. Para verificar a associação entre as variáveis independentes qualitativas e o desenvolvimento de LP, foi realizado teste de Qui-Quadrado ou Exato de Fisher. A fim de analisar a correlação entre as variáveis quantitativas, utilizou-se correlação de Spearman. Foi empregado um nível de significância estatística de 5%. Os aspectos éticos foram observados conforme preceitos estabelecidos na Resolução 466/2012 do Conselho Nacional da Saúde. A incidência de LP foi de 10,9%, com 8,7% no grupo intervenção e 13,0% no grupo controle. Não foi significante a diferença na incidência entre os grupos (p=0,343). A temperatura e umidade da pele (microclima) e a oleosidade dos calcâneos sofrem alterações em seus valores quando em uso de coberturas para prevenção de lesões por pressão. A temperatura da pele dos calcâneos que desenvolveram LP, bem como dos calcâneos em uso do FTP não apresentaram diferença significativa entre baseline e end. Os fatores associados ao desenvolvimento de LP foram idade, tempo de permanência no estudo, tempo de internação anterior à UTI, edema e eritema. O estudo fornece evidências adicionais para apoiar o uso de EMPS na prevenção de LPs. O risco relativo foi de 0,67, assim quem usa a EMPS tem 33% menos risco de desenvolver LP quando comparado aos pacientes em uso do FTP.
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- 2019
42. Quality of life and the impacte on adherence of the antiretroviral tratment with people living whit HIV
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Primeira, Marcelo Ribeiro, Padoin, Stela Maris de Mello, Soárez, Patricia Coelho de, Schwarzbold, Alexandre Vargas, and Paula, Cristiane Cardoso de
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Adesão à medicação ,Acquired immunodeficiency syndrome ,Quality of life ,Qualidade de vida ,Highly active antiretroviral therapy ,Síndrome de imunodeficiência adquirida ,HIV ,Enfermagem ,Nursing ,Terapia antirretroviral de alta atividade ,Medication adherence ,CIENCIAS DA SAUDE::ENFERMAGEM [CNPQ] - Abstract
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES The epidemic caused by the human immunodeficiency virus is a public health problem. One of the strategies for its control is the use of antiretroviral drugs by people infected by the virus. The viral load supression is expected when there is a early initiation of the treatment, and is linked to adherence toantiretroviral therapy. Already the quality of life of these people becomes important since living with this virus is a chronic health condition. Thereby, the assessment of quality of life in order to verify its impact on treatment adherence becomes a concern. The study aimed to assess whether quality of life is associated with adherence to antiretroviral therapy. Cross-sectional study, conducted inland of Rio Grande do Sul, Brazil. The scenario was the Outpatient Service of Infectious Diseases of Adults of the University Hospital of Santa Maria. The sample consisted of 156 adult participants who were infected with the virus and who had followed up on the service for at least three months. The data were collected from the "Questionnaire to assess the adherence to antiretroviral treatment in people with HIV/AIDS - CEAT-VIH" and "HIV/AIDS-Targeted Quality of Life Instrument (HAT-QoL)" for evaluation quality of life. The collected data were inserted on Epi Info 7.0 software, and its analyzes were performed in SPSS 21.0. Frequency analyzes were performed for the questionnaire scores, following their respective manuals. Subsequently, logistic regressions were performed to verify the associations between quality of life, compliance and biological markers of viral load and CD4 lymphocytes. Regarding the degree of compliance, 1.3% had low adherence (inadequate), 66% presented insufficient adherence and 32.7% adhered strictly (adequate). Quality of life obtained the lowest scores in the dimensions related to "Disclosure concerns" (47,40) and "Financial worries" (49,20). The dimensions with the highest scores were "Satisfaction with life" (75,52), "Sexual function" (80,69) and "Medication worries" (84,20). The "Overall function", "Medication worries" and "Provider trust" dimensions were statistically significant and positive regarding compliance, and "Disclosure concerns" presented negative statistical significance related to compliance. Moreover, it was verified that the highest quality of life scores were related to strict compliance. Finally, increased viral load is seen as detrimental to quality of life dimensions. Based on these results, it is expected that health care providers can use quality of life assessment and their influence on compliance to propose health promotion strategies for this population, intervening in the most impaired quality of life dimensions in order to prevent interference in adhesion to the antiretroviral therapy and consequently in the biological markers. A epidemia provocada pela disseminação do vírus da imunodeficiência humana é um problema de saúde pública. Uma das estratégias para o seu controle é o uso de medicamentos antirretrovirais pelas pessoas infectadas pelo vírus. A expectativa quanto ao início precoce desse tratamento é a supressão da carga viral, que está vinculada à adesão ao tratamento. Já a qualidade de vida dessas pessoas se torna importante uma vez que viver com esse vírus é uma condição crônica de saúde. Dessa forma, a avaliação da qualidade de vida a fim de verificar seu impacto na adesão se torna uma preocupação. O objetivo do estudo foi avaliar se a qualidade de vida está associada à adesão ao tratamento antirretroviral. Estudo transversal, realizado no interior do Rio Grande do Sul, Brasil. O cenário foi o serviço de Ambulatório de Doenças Infecciosas de Adultos do Hospital Universitário de Santa Maria. A amostra constitui-se de 156 participantes adultos infectados pelo vírus e que realizavam acompanhamento no serviço há pelo menos três meses. Os dados foram coletados a partir do questionário de caracterização dos adultos, pelo questionário de avaliação da adesão ao tratamento antirretroviral em pessoas com HIV/AIDS – CEAT-VIH e pelo HIV/AIDS-Targeted Quality of Life Instrument – HAT-QoL, para avaliação da qualidade de vida. Os dados coletados foram inseridos no software Epi Info 7.0, e suas análises realizadas no SPSS 21.0. Foram realizadas análises por frequência para as pontuações dos questionários, seguindo seus respectivos manuais. Posteriormente foram realizadas regressões logísticas a fim de verificar as associações entre a qualidade de vida, adesão e os marcadores biológicos de carga viral e linfócitos TCD4. Quanto ao grau de adesão, 1,3% obteve baixa adesão (inadequada), 66% apresentou adesão insuficiente e 32,7% adesão estrita (adequada). A qualidade de vida obteve os menores escores nas dimensões relacionadas à “Preocupações com o sigilo” (47,40) e “Preocupações financeiras” (49,20). As dimensões com maiores pontuações foram a “Satisfação com a vida” (75,52), “Função sexual” (80,69) e “Preocupações com a medicação” (84,20). As dimensões “Função geral”, “Preocupações com a medicação” e “Confiança no profissional”, apresentaram significância estatística e positiva quanto à adesão, já “Preocupações com o sigilo” apresentou significância estatística negativa relacionada à adesão. Ainda, verificou-se que os maiores escores de qualidade de vida estiveram relacionados à adesão estrita. Finalmente, o aumento de carga viral é visto como prejudicial às dimensões de qualidade de vida. A partir destes resultados, espera-se que os profissionais de saúde possam utilizar a avaliação de qualidade de vida e sua influência na adesão para propor estratégias de promoção à saúde desta população, intervindo nas dimensões de qualidade de vida mais comprometidas, a fim de prevenir que estas interfiram na adesão ao tratamento antirretroviral e consequentemente nos marcadores biológicos.
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- 2018
43. Clinical and epidemiological characterization of pneumonia hospitalization cases at Hospital Universitario de Santa Maria: a cross-sectional study
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Daronco, Alexandre, Beck, Maristela de Oliveira, Schwarzbold, Alexandre Vargas, and Pedro, Fabio Lopes
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CIENCIAS DA SAUDE::MEDICINA [CNPQ] ,Epidemiology ,Microbiologia ,Pneumonia ,Epidemiologia ,Microbiology - Abstract
Pneumonia is an infection of the lung parenchyma. It is the result of a complex interaction between aggressive agents and the host's immune response. This pathology has great relevance in the different health services in the world and also in the Unified Health System, being one of the main causes of hospitalization in Brazil. This study aims to investigate the characteristics of patients hospitalized at the Santa Maria University Hospital due to the diagnosis of pneumonia, as well as to know the empirical choice of antimicrobials, the microorganisms isolated in sputum cultures and the clinical outcomes of hospitalization. A total of 104 patients with suspected diagnosis of pneumonia were obtained between January 2014 and February 2016. The characterization was performed in 63 cases. The minimum age was 18 years and the maximum age was 93 years, and in 33 cases (52.4%) the age was equal to or greater than 65 years. The clinical outcome of discharge occurred in 35 cases (55.6%) and death was observed in the others. Twenty-nine patients (41.3%) had an isolated microorganism, especially Gram-negative, collected sputum collected at the time of arrival. The empiric antimicrobial most frequently prescribed at the time of admission was Piperacillin + Tazobactam (25 cases - 39.57%), in monotreptica or in combination with another antimicrobial. The particularities of the cases of pneumonia studied can be attributed to the fact that the Santa Maria University Hospital is a reference center for cases of greater complexity. The data obtained in this study may help to better understand the problems related to pneumonia in the Santa Maria University Hospital. A pneumonia é uma infecção do parênquima pulmonar. É resultante da complexa interação entre agentes agressores e resposta imunológica do hospedeiro. Tal patologia possui grande relevância nos diferentes serviços de saúde no mundo e também no Sistema Único de Saúde, sendo uma das principais causas de internação no Brasil. Este estudo tem por objetivos investigar as características dos pacientes internados no Hospital Universitário de Santa Maria devido ao diagnóstico de pneumonia, bem como conhecer as escolhas empíricas de antimicrobianos, os microrganismos isolados em culturais de escarro e os desfechos clínicos da internação. Um total de 104 pacientes com suspeita diagnóstica de pneumonia foram obtidos no período entre janeiro de 2014 a fevereiro de 2016. A caracterização foi realizada em 63 casos. A idade mínima foi de 18 anos e a idade máxima foi de 93 anos, sendo que em 33 casos (52,4%) a idade era igual ou superior a 65 anos. O desfecho clínico de alta ocorreu em 35 casos (55,6%) e óbito foi observado nos demais. Possuíam material de escarro coletado no momento da chegada 29 pacientes, sendo que 12 destes (41,3%) tiveram microrganismo isolado, com especial destaque para gram-negativos. O antimicrobiano empírico mais frequentemente prescrito no momento da internação foi Piperacilina+Tazobactam (25 casos – 39,57%), em monotorepia ou em combinação com outro antimicrobiano. As particularidades dos casos de pneumonia estudados podem ser atribuídos ao fato do Hospital Universitário de Santa Maria ser centro de referência para casos de maior complexidade. Os dados obtidos neste estudo podem auxiliar em melhor compreensão da problemática relacionada a pneumonia no Hospital Universitário de Santa Maria.
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- 2017
44. Concordance of cardiovascular risk score in HIV and HCV infected individuals
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Librelotto, Paula Rubin Facco, Beck, Maristela de Oliveira, Pedro, Fabio Lopes, and Schwarzbold, Alexandre Vargas
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Escore de risco cardiovascular ,Hepatite C ,CIENCIAS DA SAUDE::MEDICINA [CNPQ] ,HIV ,Framingham risk score ,Score Reynolds risk and global risk score ,Escore de risco de Reynolds e escore de risco global ,Hepatitis C ,Escore de risco de Framingham ,Risk cardiovascular score - Abstract
The Acquired Immunodeficiency Syndrome (AIDS) caused by the human immunodeficiency virus (HIV) is a serious, emergent, pandemic disease, considered of the biggest problems in the world. The introduction of Highly Active Antirretroviral Therapy (HAART) allowed immune deficiency reduction caused by the virus, decrease morbidity associated with AIDS and, consequently, the increased life expectancy. The aging of this population has been accompanied by high cardiovascular risk, and the mechanisms responsible for this increase are not entirely clear. It is believed that chronic inflammation generated by the HIV virus and hepatitis C virus (HCV), the metabolic changes related to the viruses and antiretroviral therapy are related to the cardiovascular morbidity and mortality. Knowing the cardiovascular risk of these patients through the use of clinical risk scores is important in order to plan possible interventions which can reduce the risks. This transversal study evaluated the prevalence of cardiovascular risk in 128 patients divided into three groups: 52 patients with monoinfected by HIV, 33 subjects with monoinfection by HCV, 33 subjects coinfected by HIV / HCV, at the University Hospital of Santa Maria - Brazil. For that, different clinical risk scores were applied: the Framingham Risk Score (FRS), the Reynolds Risk Score (RRS) and Global Risk Score (GRS). We evaluated the concordance and correlation between the methods and the percentage of patients who were reclassified after the application of different scores. The prevalence of cardiovascular risk among all the populations studied was 8.7% for FRS, 4.3% for RRS and 48.1% for GRS. HCV patients showed higher risk prevalence when compared to other patients. FRS classified more patients as low risk in all population subgroups, suggesting that it is a score that underestimates the risk for HIV and HCV populations. At our study, 9.6% of HIV monoinfected population had moderate to high risk according to FRS, while 50% had moderate to high risk of the GRS, showing that depending on the method used to assessment the risk, patients are reclassified, which implies in different measures and prevention interventions. The risk scores were weak concordance and correlation with each other, independent of the evaluated subgroup. This study emphasizes the need to establish specific risk scores for the HIV population. A Síndrome da Imunodeficiência Adquirida (SIDA) causada pelo vírus da imunodeficiência humana (HIV) é uma doença pandêmica grave, emergente, considerada um dos maiores problemas de saúde mundial. A introdução da terapia antirretroviral de alta eficácia permitiu a redução da deficiência imunológica causada pelo vírus, diminuição da morbimortalidade associadas a SIDA e, consequentemente, o aumento da expectativa de vida. O envelhecimento dessa população tem sido acompanhado por elevado risco cardiovascular, sendo que os mecanismos responsáveis por este aumento não são totalmente esclarecidos. Acredita-se que o processo inflamatório crônico gerado pelo vírus HIV e da hepatite C (HCV), as alterações metabólicas relacionados aos vírus e a terapia antirretroviral estejam relacionados a morbimortalidade cardiovascular. Conhecer o risco cardiovascular desses pacientes através da aplicação de escores de risco clínicos é importante, a fim de planejar possíveis intervenções que possam reduzi-lo. Esse estudo transversal avaliou a prevalência do risco cardiovascular em 128 pacientes, divididos em três grupos: 52 pacientes com monoinfecção pelo HIV, 33 monoinfectados pelo HCV, 33 coinfectados HIV/HCV, no Hospital Universitário de Santa Maria – Brasil. Para isso, foram aplicados diferentes escores clínicos de risco: Escore de Risco de Framingham (ERF), Escore de Risco de Reynolds (ERR) e Escore de Risco Global (ERG). Foram avaliadas a concordância e a correlação entre os métodos e o percentual de pacientes que foram reclassificados após a aplicação dos diferentes escores. A prevalência de risco cardiovascular entre toda a população estudada foi 8,7% pelo ERF, 4,3% pelo ERR e 48,1% pelo ERG. Os pacientes HCV apresentaram maior prevalência de risco quando comparado aos demais pacientes. O ERF classificou mais pacientes como baixo risco em todos os subgrupos da população, sugerindo ser um escore que subestime o risco na população HIV e HCV. No nosso estudo 9,6% da população monoinfectada pelo HIV teve risco de moderado a alto pelo ERF, enquanto 50% teve risco de moderado a alto pelo ERG, demostrando que dependendo do método utilizado para avaliação do risco, os pacientes são reclassificados, o que implica em diferentes medidas e intervenções de prevenção. Os escores de risco tiveram fraca concordância e correlação entre si, independente do subgrupo avaliado. Esse estudo enfatiza a necessidade de se criar escores de risco específicos para a população HIV.
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- 2016
45. Sporothrix schenckii complex: photodynamic inactivation, influency of melanin in antifungal activity and drug combination
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Mario, Débora Alves Nunes, Alves, Sydney Hartz, Pereira, Daniela Isabel Brayer, Santurio, Janio Morais, Zanette, Régis Adriel, and Schwarzbold, Alexandre Vargas
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Melanina ,Terapia fotodinâmica ,Melanin ,Complexo Sporothrix schenckii ,Sporothrix schenckii complex ,Antifungal combination ,CIENCIAS DA SAUDE::FARMACIA [CNPQ] ,Combinação de antifúngicos ,Photodynamic therapy - Abstract
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Sporotrichosis is a subcutaneous mycosis that affects humans and animals, and it is caused by dimorphic melanized fungi belonging to the genus Sporothrix. Sporotrichosis is mainly acquired by traumatic implantation of the fungus into the dermis through scratches inflicted by domestic animals or by handling plants. This study approaches: a) the in vitro susceptibility of Sporothrix schenckii complex species to photodynamic inactivation using methylene blue as a photosensitizer and laser as the light source; b) the combination of amphotericin B plus posaconazole in a murine model of systemic infection by S. brasiliensis and S. schenckii sensu stricto, seeking to enhance the treatment of disseminated sporotrichosis; c) the interference of fungal melanin in the in vitro susceptibility of S. brasiliensis and S. schenckii sensu stricto to amphotericin B and itraconazole. In the photodynamic therapy study we have applied methylene blue as a photosensitizing agent and Light emitting diode (InGaAlP) against Sporothrix schenckii complex species in an in vitro assay. The viability of the conidia was determined through the counting of colony forming units. The activity of amphotericin B and posaconazole alone or in combination was evaluated by using a microdilution checkerboard method. For the in vivo study, OF-1 mice were intravenously (i.v.) infected with a lethal inoculum of 2 x 107 CFU/animal. Two strains of S. brasiliensis and two of S. schenckii were tested. Animals received amphotericin i.v. at suboptimal dose i.e., 0.3 mg/kg, in combination with oral posaconazole at 2.5 mg/kg, 5 mg/kg or 10 mg/kg BID. Results were compared with their respective monotherapies and efficacy was evaluated by prolongation of survival and reduction of tissue burden in spleen and liver. In the study of the interference of melanin in the susceptibility of S. brasiliensis and S. schenckii sensu stricto, yeast cells were cultivated in minimal medium with or without L-DOPA in order to induce the production of melanin. Microdilution and time-kill methods were used to determine the antifungal activity against yeast cells with different amounts of melanin. The laser light (InGaAlP) together with a methylene blue photosensitizer were able to significantly reduce the growth of all the tested Sporothrix strains. In vitro data demonstrated a synergistic effect of the combination and although posaconazole alone was effective against sporotrichosis, efficacy was increased when combined with amphotericin B. The maximum efficacy of the combinations was obtained with posaconazole 5 mg/kg. The killing assay showed that melanization protected isolates within the Sporothrix schenckii complex from amphotericin B, particularly in the lower concentrations tested. The conclusions of the present study are: a) the in vitro inhibition of Sporothrix spp. isolates by laser light deserves in vivo experimental and clinical studies since it may be a promising treatment for cutaneous and subcutaneous sporotrichosis; b) posaconazole in combination with suboptimal doses of amphotericin B could be an option in the treatment of disseminated sporotrichosis especially when itraconazole or amphotericin B at optimal doses are contraindicated; c) combination studies of amphotericin B with inhibitors of melanin are required in order to avoid this effect. A esporotricose é uma micose subcutânea que afeta homens e animais, e é causada por fungos dimórficos melanizados pertencentes ao gênero Sporothrix. Pode ser principalmente adquirida por implantação traumática do fungo na derme através da arranhadura de animais domésticos ou manipulação de plantas contaminadas. O presente estudo investigou: a) a suscetibilidade in vitro de espécies do Complexo Sporothrix schenckii à inativação fotodinâmica; b) a combinação de anfotericina B e posaconazol em modelo murino de infecção sistêmica por S. brasiliensis e S. schenckii stricto sensu, buscando melhorar o tratamento da esporotricosse disseminada; c) a interferência da melanina fúngica na suscetibilidade in vitro de S. brasiliensis e S. schenckii stricto sensu à anfotericina B e itraconazol. No estudo da terapia fotodinâmica foi aplicado azul de metileno como fotossensibilizador e emissão de luz diiodo (InGaAlP) frente espécies do complexo Sporothrix schenckii em ensaio in vitro. A viabilidade dos conídios foi determinada através de contagem de unidades formadoras de colônia (UFC). A atividade da anfotericina B e posaconazol sozinhos ou combinados foi avaliada segundo a técnica de microdiluição em caldo e técnica de checkerboard. No estudo in vivo, camundongos OF-1 foram infectados com um inóculo de 2 x 107 UFC/animal. Foram utilizadas duas cepas de S. brasiliensis e duas cepas de S. schenckii. Os animais receberam doses de 0.3 mg/kg de anfotericina B em combinação com 2.5 mg/kg e 5 mg/kg de posaconazol. Os resultados foram comparados com as respectivas monoterapias e a eficácia foi avaliada através do prolongamento da sobrevivência e redução da carga fúngica no fígado e baço. No estudo da interferência da melanina na suscetibilidade de S. brasiliensis e S. schenckii stricto sensu à anfotericina B e itraconazol, células leveduriformes foram cultivadas em meio mínimo com e sem L-DOPA. Métodos de microdiluição e tempo de morte foram utilizados para determinar a atividade dos antifúngicos frente às células com diferentes quantidades de melanina. A luz laser (InGaAlP) em conjunto com o azul de metileno foram capazes de reduzir significativamente o crescimento de todas as cepas de Sporothrix testadas. Os dados in vitro demonstraram um efeito sinérgico da combinação de posaconazol e anfotericina B, e, apesar de o posaconazol 5 mg/kg sozinho apresentar eficácia contra a esporotricose, teve sua eficiência aumentada quando combinado com anfotericina B 0,3 mg/kg. A técnica de tempo de morte mostrou que a melanização protegeu os isolados do complexo Sporothrix schenckii da anfotericina B, particularmente na concentração mais baixa testada. Desta forma, as conclusões do presente estudo são: a) a inibição fotodinâmica in vitro de isolados de Sporothrix merece estudos experimentais e clínicos, uma vez que pode ser um tratamento promissor para a esporotricose cutânea e subcutânea; b) o posaconazol em combinação com dose baixa de anfotericina B pode ser uma opção para o tratamento de esporotricose disseminada, especialmente quando itraconazol e anfotericina B são contraindicados; c) estudos de combinação de anfotericina B com inibidores de melanina são necessários a fim de evitar o efeito protetor da melanina contra as defesas do organismo e contra antifúngicos.
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- 2015
46. Identification of infection Helicobacter pylori antigen through fecal test
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Nora, Magali Dalla, Fagundes, Renato Borges, Schwarzbold, Alexandre Vargas, Alves, Sydney Hartz, and Premaor, Melissa Orlandin
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Helicobacter pylori ,CIENCIAS DA SAUDE [CNPQ] ,Teste fecal ,Diagnóstico ,Diagnosis ,Fecal test - Abstract
Introduction: The diagnosis of Helicobacter pylori (H. pylori) infection can be performed by non-invasive and invasive methods. The identification through test of fecal antigen (FAT) method is a non-invasive, simple, and relatively inexpensive. The aim of this study was to determine the diagnostic performance of immunoassay FAT in the identification of H. pylori infection. Methods: H. pylori antigens were identified in the stools of dyspeptic patients undergoing upper gastrointestinal endoscopy (UGE). The identification of H. pylori antigens was carried out through the ImmunoCard STAT! HpSA. Histopathology and urease test were the gold standard. Results: We studied 100 patients, 80% women and 20% men, with mean age of 52.7±11.8 years. The prevalence of H. pylori infection was 48%. The FAT immunoassay showed the following measures of diagnostic performance: specificity of 96% (95%CI 89.1-98.9); sensitivity of 65% (95%C I 56.9-67.6); positive predictive value of 94% (95%CI 82.8-98.3) and negative predictive value of 75% (95%CI 69.1-76.8). The accuracy was 80% (95%CI 74-84) and the prevalence odds ratio was 45,6 (95%CI 10,7-188,5). Conclusion: The FAT immunoassay presented high specificity and high positive predictive value. However, due to low sensitivity it would be appropriate to test it in a post-treatment period to assess the eradication of H. pylori. Introdução: O diagnóstico da infecção por Helicobacter pylori (H. pylori) pode ser realizado por métodos invasivos e não invasivos. A identificação através do teste do antígeno fecal (TAF) é um método não invasivo, simples, fácil e relativamente barato. O objetivo deste estudo foi determinar o desempenho diagnóstico do TAF imunocromatográfico na identificação da infecção pelo H. pylori. Métodos: A pesquisa de antígenos fecais do H. pylori foi realizada através do ImmunoCard STAT! HpSA em pacientes dispépticos submetidos à endoscopia digestiva alta (EDA) com coleta de biópsias para histopatologia e teste da urease, utilizados como padrão ouro. Resultados: Participaram do estudo 100 pacientes, 80% eram mulheres e 20% homens, com média de idade de 52,7±11,8 anos. A prevalência da infecção pelo H. pylori foi de 48%. O TAF imunocromatográfico apresentou as seguintes medidas de desempenho diagnóstico: especificidade 96,2% (IC95% 89,1-98,9), sensibilidade 64,6% (IC95% 56,9-67,6), valor preditivo positivo 93,9% (IC95% 82,8-98,3) e valor preditivo negativo 74,6% (IC95% 69,1-76,8). A acurácia foi de 80% (IC95% 74-84). A razão de chances de prevalência para TAF positivo foi 45,6 (IC95% 10,7-188,5). Conclusão: O TAF imunocromatográfico apresentou elevada especificidade e valor preditivo positivo. Porém, devido sua baixa sensibilidade seria adequado testá-lo em um período pós-tratamento na avaliação da erradicação do H. pylori.
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- 2015
47. Palliative care and COVID-19: acknowledging past mistakes to forge a better future.
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de Andrade CRM, Luz FST, de Oliveira NR, Kopittke L, Santa Rosa LMM, Gomes AGDR, Bartolazzi F, Francisco SC, da Costa FR, Jorge AO, Cimini CCR, Carneiro M, Ruschel KB, Schwarzbold AV, Ponce D, Ferreira MAP, Guimarães Júnior MH, Silveira DV, Aranha FG, de Carvalho RLR, de Godoy MF, Viana LMP, Hirakata VN, Bicalho MAC, and Marcolino MS
- Abstract
Context: COVID-19 induces complex distress across physical, psychological, and social realms and palliative care (PC) has the potential to mitigate this suffering significantly., Objectives: To describe the clinical characteristics and outcomes of COVID-19 patients with an indication of PC, compared to patients who had no indication, in different pandemic waves., Methods: This retrospective multicenter observational cohort included patients from 40 hospitals, admitted from March 2020 to August 2022. Patients who had an indication of palliative care (PC) described in their medical records were included in the palliative care group (PCG), while those who had no such indication in their medical records were allocated to the non-palliative care group (NPCG)., Results: Out of 21,158 patients, only 6.7% had indication for PC registered in their medical records. The PCG was older, had a higher frequency of comorbidities, exhibited higher frailty, and had a higher prevalence of clinical complications and mortality (81.4% vs. 17.7%, p < 0.001), when compared to the NPCG. Regarding artificial life support, the PCG had a higher frequency of dialysis (20.4% vs. 10.1%, p < 0.001), invasive mechanical ventilation (48.2% vs. 26.0%, p < 0.001) and admission to the intensive care unit (53.6% vs. 35.4%, p < 0.001). These differences were consistent across all three waves., Conclusion: A low proportion of patients received PC. Patients in PCG were more fragile, had more clinical complications, and had a higher mortality. On the contrary to our expectations, they received more artificial life support in all three waves. Taken together, these findings suggest that decisions regarding PC indication were made too late, within a context of end-of-life and therapeutic failure., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Andrade, Luz, Oliveira, Kopittke, Santa Rosa, Gomes, Bartolazzi, Francisco, Costa, Jorge, Cimini, Carneiro, Ruschel, Schwarzbold, Ponce, Ferreira, Guimarães Júnior, Silveira, Aranha, Carvalho, Godoy, Viana, Hirakata, Bicalho and Marcolino.)
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- 2024
- Full Text
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48. Real-Life Data on Hydroxychloroquine or Chloroquine with or Without Azithromycin in COVID-19 Patients: A Retrospective Analysis in Brazil.
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Souza-Silva MVR, Pereira DN, Pires MC, Vasconcelos IM, Schwarzbold AV, Vasconcelos DH, Pereira EC, Manenti ERF, Costa FR, Aguiar FC, Anschau F, Bartolazzi F, Nascimento GF, Vianna HR, Batista JDL, Machado-Rugolo J, Ruschel KB, Ferreira MAP, Oliveira LS, Menezes LSM, Ziegelmann PK, Tofani MGT, Bicalho MAC, Nogueira MCA, Guimarães-Júnior MH, Aguiar RLO, Rios DRA, Polanczyk CA, and Marcolino MS
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- Aged, Female, Humans, Male, Middle Aged, Arrhythmias, Cardiac drug therapy, Azithromycin therapeutic use, Brazil epidemiology, Cohort Studies, COVID-19, Retrospective Studies, SARS-CoV-2, Chloroquine adverse effects, COVID-19 Drug Treatment, Hydroxychloroquine adverse effects
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Background: Despite no evidence showing benefits of hydroxychloroquine and chloroquine with or without azithromycin for COVID-19 treatment, these medications have been largely prescribed in Brazil., Objectives: To assess outcomes, including in-hospital mortality, electrocardiographic abnormalities, hospital length-of-stay, admission to the intensive care unit, and need for dialysis and mechanical ventilation, in hospitalized COVID-19 patients who received chloroquine or hydroxychloroquine, and to compare outcomes between those patients and their matched controls., Methods: A retrospective multicenter cohort study that included consecutive laboratory-confirmed COVID-19 patients from 37 Brazilian hospitals from March to September 2020. Propensity score was used to select matching controls by age, sex, cardiovascular comorbidities, and in-hospital use of corticosteroid. A p-value <0.05 was considered statistically significant., Results: From 7,850 COVID-19 patients, 673 (8.6%) received hydroxychloroquine and 67 (0.9%) chloroquine. The median age in the study group was 60 years (46 - 71) and 59.1% were women. During hospitalization, 3.2% of patients presented side effects and 2.2% required therapy discontinuation. Electrocardiographic abnormalities were more prevalent in the chloroquine/hydroxychloroquine group (13.2% vs. 8.2%, p=0.01), and the long corrected QT interval was the main difference (3.6% vs. 0.4%, p<0.001). The median hospital length of stay was longer in the HCQ/CQ + AZT group than in controls (9.0 [5.0, 18.0] vs. 8.0 [4.0, 14.0] days). There was no statistical differences between groups in intensive care unit admission (35.1% vs. 32.0%; p=0.282), invasive mechanical ventilation support (27.0% vs. 22.3%; p=0.074) or mortality (18.9% vs. 18.0%; p=0.682)., Conclusion: COVID-19 patients treated with chloroquine or hydroxychloroquine had a longer hospital length of stay, when compared to matched controls. Intensive care unit admission, invasive mechanical ventilation, dialysis and in-hospital mortality were similar.
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- 2023
- Full Text
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49. Correction: Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients.
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de Azevedo Figueiredo F, Ramos LEF, Silva RT, Ponce D, de Carvalho RLR, Schwarzbold AV, de Oliveira Maurílio A, Scotton ALBA, Garbini AF, Farace BL, Garcia BM, da Silva CTCA, Cimini CCR, de Carvalho CA, Dos Santos Dias C, Silveira DV, Manenti ERF, de Almeida Cenci EP, Anschau F, Aranha FG, de Aguiar FC, Bartolazzi F, Vietta GG, Nascimento GF, Noal HC, Duani H, Vianna HR, Guimarães HC, de Alvarenga JC, Chatkin JM, de Morais JDP, Machado-Rugolo J, Ruschel KB, Martins KPMP, Menezes LSM, Couto LSF, de Castro LC, Nasi LA, de Souza Cabral MA, Floriani MA, Souza MD, Souza-Silva MVR, Carneiro M, de Godoy MF, Bicalho MAC, Lima MCPB, Aliberti MJR, Nogueira MCA, Martins MFL, Guimarães-Júnior MH, da Cunha Severino Sampaio N, de Oliveira NR, Ziegelmann PK, Andrade PGS, Assaf PL, de Lima Martelli PJ, Delfino-Pereira P, Castro Martins R, Menezes RM, Francisco SC, Araújo SF, Oliveira TF, de Oliveira TC, Souza Sales TL, Avelino-Silva TJ, Ramires YC, Pires MC, and Marcolino MS
- Published
- 2023
- Full Text
- View/download PDF
50. Myocardial Injury and Prognosis in Hospitalized COVID-19 Patients in Brazil: Results From The Brazilian COVID-19 Registry.
- Author
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Barbosa HC, Martins MAP, Jesus JC, Meira KC, Passaglia LG, Sacioto MF, Bezerra AFB, Schwarzbold AV, Maurílio AO, Farace BL, Silva CTCAD, Cimini CCR, Silveira DV, Carazai DDR, Ponce D, Costa EVA, Manenti ERF, Cenci EPA, Bartolazzi F, Madeira GCC, Nascimento GF, Velloso IVP, Batista JDL, Morais JDP, Carvalho JDSN, Ruschel KB, Martins KPMP, Zandoná LB, Menezes LSM, Kopittke L, Castro LC, Nasi LA, Floriani MA, Souza MD, Carneiro M, Bicalho MAC, Lima MCPB, Godoy MF, Guimarães-Júnior MH, Mendes PM, Delfino-Pereira P, Ribeiro RJE, Finger RG, Menezes RM, Francisco SC, Araújo SF, Oliveira TF, Oliveira TC, Polanczyk CA, and Marcolino MS
- Subjects
- Female, Humans, Male, Middle Aged, Brazil epidemiology, C-Reactive Protein, Cohort Studies, Prognosis, Aged, COVID-19, Heart Injuries
- Abstract
Background: Cardiovascular complications of COVID-19 are important aspects of the disease's pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce., Objectives: To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry., Methods: This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05., Results: Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels., Conclusion: Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients.
- Published
- 2023
- Full Text
- View/download PDF
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