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1. The gap-size influence on the excitation of magnetorotational instability in cylindrical Couette flows

Author

Rüdiger, G. and Schultz, M.

Subjects
Physics - Fluid Dynamics
Abstract

The excitation conditions of the magnetorotational instability are studied for axially unbounded Taylor-Couette flows of various gap widths between the cylinders. The cylinders are considered as made from both perfect-conducting or insulating material and the conducting fluid with a finite but small magnetic Prandtl number rotates with a quasi-Keplerian velocity profile. The solutions are optimized with respect to the wave number and the Reynolds number of the rotation of the inner cylinder. For the axisymmetric modes we find the critical Lundquist number of the applied axial magnetic field the lower the wider the gap between the cylinders. A similar result is obtained for the induced cell structure: the wider the gap the more spherical the cells are. The marginal rotation rate of the inner cylinder -- for fixed size of the outer cylinder -- always possesses a minimum for not too wide and not too narrow gap widths. For perfect-conducting walls the minimum lies at $r_{\rm in}\simeq 0.4$ while it is at $r_{\rm in}\simeq 0.5$ for insulating walls where $r_{\rm in}$ is the normalized radius of the inner cylinder. The lowest magnetic field amplitudes to excite the instability are required for Taylor-Couette flows between perfect-conducting cylinders with gaps corresponding to $r_{\rm in}\simeq 0.2$. For even wider and also for very thin gaps the needed magnetic fields and rotation frequencies are shown to become rather huge. Also the nonaxisymmetric modes with $|m|=1$ have been considered. Their excitation generally requires stronger magnetic fields and higher magnetic Reynolds numbers in comparison to those for the axisymmetric modes which is true for wide-gap containers with $r_{\rm in} \lesssim 0.3$., Comment: 12 pages, 6 figures

Published
2023

2. Improving Medication Adherence Levels in Inflammatory Bowel Disease (IBD) Patients: A Narrative Evidence-Based Review

Author

Amiesimaka OI, Aluzaite K, Braund R, and Schultz M

Subjects
inflammatory bowel disease, ibd, interventions, medication adherence, Medicine (General), R5-920
Abstract

Obreniokibo Ibifubara Amiesimaka,1 Kristina Aluzaite,1 Rhiannon Braund,2 Michael Schultz1,3 1Gastroenterology Research Unit, Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand; 2New Zealand Pharmacovigilance Centre, University of Otago, Dunedin, New Zealand; 3Gastroenterology Unit, Dunedin Hospital, Te Whatu Ora/Health New Zealand, Dunedin, New ZealandCorrespondence: Michael Schultz, Gastroenterology Research Unit, Department of Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, 9054, New Zealand, Tel +64 3 479 0999, Email michael.schultz@otago.ac.nzAbstract: Inflammatory bowel disease (IBD) management is typified by a long-term medication regimen which can comprise multiple medications prescribed in different combinations, doses, frequencies, and with various administration routes. This complexity can make medication adherence (MA) – patients taking their medications per the prescription – for patients with IBD a challenge. The research corpus contains diverse interventions aimed at improving MA in patients with IBD. Therefore, to condense the evidenced strategies for ease of reference, this narrative evidence-based review broadly outlines the patient-level interventions reported. The interventions are grouped as educational, behavioural, cognitive-behavioural, and multicomponent. They, however, present mixed results as to their efficacy at improving MA, with those employing combined approaches being the most promising. This reflects the reality that MA is impacted by multiple factors encompassing those pertaining to the patient, disease, therapy, patients’ socioeconomic status, and health system. Hence, the most ideal interventions would likely be multifaceted patient-level interventions alongside policy/system-level strategies, to maximise the potential for successfully improving patients’ MA. These findings might have been impacted by the heterogeneity of the studies in terms of the method of MA assessment, duration of interventions, and more besides.Keywords: Inflammatory Bowel Disease, IBD, interventions, medication adherence

Published
2024

3. On the toroidal-velocity anti-dynamo theorem under the presence of nonuniform electric conductivity

Author

Rüdiger, G. and Schultz, M.

Subjects
Physics - Fluid Dynamics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Laminar electrically conducting Couette flows with the hydrodynamically stable quasi-Keplerian rotation profile and non-uniform conductivity are probed for dynamo instability. In spherical geometry the equations for the poloidal and the toroidal field components completely decouple, resulting in free decay, regardless of the spatial distribution of the electric conductivity. In cylindrical geometry the poloidal and toroidal components do not decouple, but here also we do not find dynamo excitations for the cases that the electric conductivity only depends on the radius or -- much more complex -- that it only depends on the azimuthal or the axial coordinate. The transformation of the plane-flow dynamo model of Busse \& Wicht (1992) to cylindrical or spherical geometry therefore fails. It is also shown that even the inclusion of axial flows of both directions does {\em not} support the dynamo mechanism. The Elsasser toroidal-velocity antidynamo theorem, according to which dynamos without any radial velocity component cannot work, is thus not softened by non-uniform conductivity distributions., Comment: 8 pages, 6 figures

Published
2021
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6. Destabilization of super-rotating Taylor-Couette flows by current-free helical magnetic fields

Author

Rüdiger, G., Schultz, M., and Hollerbach, R.

Subjects
Physics - Fluid Dynamics
Abstract

In an earlier paper we showed that the combination of azimuthal magnetic fields and super-rotation in Taylor-Couette flows of conducting fluids can be unstable against non-axisymmetric perturbations if the magnetic Prandtl number of the fluid is $Pm\neq 1$. Here we demonstrate that the addition of a weak axial field component may allow axisymmetric perturbation patterns for $Pm$ of order unity depending on the boundary conditions. The axisymmetric modes only occur for magnetic Mach numbers (of the azimuthal field) of order unity, while higher values are necessary for non-axisymmetric modes. The typical growth time of the instability and the characteristic time scale of the axial migration of the axisymmetric mode are long compared with the rotation period, but short compared with the magnetic diffusion time. The modes travel in the positive or negative $z$-direction along the rotation axis depending on the sign of $B_\phi B_z$. We also demonstrate that the azimuthal components of flow and field perturbations travel in phase if $|B_\phi|\gg |B_z|$, independent of the form of the rotation law. Within a short-wave approximation for thin gaps it is also shown (in an Appendix) that for {\em ideal} fluids the considered helical magnetorotational instability (HMRI) only exists for rotation laws with negative shear., Comment: 18 pages, 10 Figures

Published
2020
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7. Large-scale dynamo action of magnetized Taylor-Couette flows

Author

Rüdiger, G. and Schultz, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Physics - Fluid Dynamics
Abstract

A conducting Taylor-Couette flow with quasi-Keplerian rotation law containing a toroidal magnetic field serves as a mean-field dynamo model of the Tayler-Spruit-type. The flows are unstable against nonaxisymmetric perturbations which form electromotive forces defining $\alpha$ effect and eddy diffusivity. If both degenerated modes with $m=\pm 1$ are excited with the same power then the global $\alpha$ effect vanishes and a dynamo cannot work. It is shown, however, that the Tayler instability produces finite $\alpha$ effects if only an isolated mode is considered but this intrinsic helicity of the single-mode is too low for an $\alpha^2$ dynamo. Moreover, an $\alpha\Om$ dynamo model with quasi-Keplerian rotation requires a minimum magnetic Reynolds number of rotation of ${\rm Rm}\simeq 2.000$ to work. Whether it really works depends on assumptions about the turbulence energy. For a steeper-than-quadratic dependence of the turbulence intensity on the magnetic field, however, dynamos are only excited if the resulting magnetic eddy diffusivity approximates its microscopic value, $\eta_{\rm T}\simeq \eta$. By basically lower or larger eddy diffusivities the dynamo instability is suppressed., Comment: 12 pages, 12 figures

Published
2019
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8. Non-diffusive angular momentum transport in rotating $\bf z$-pinches

Author

Rüdiger, G. and Schultz, M.

Subjects
Physics - Plasma Physics, Astrophysics - Solar and Stellar Astrophysics, Physics - Fluid Dynamics
Abstract

The stability of conducting Taylor-Couette flows under the presence of toroidal magnetic background fields is considered. For strong enough magnetic amplitudes such magnetohydrodynamic flows are unstable against nonaxisymmetric perturbations which may also transport angular momentum. In accordance with the often used diffusion approximation one expects the angular momentum transport vanishing for rigid rotation. In the sense of a nondiffusive $\Lambda$ effect, however, even for {\em rigidly} rotating $z$-pinches an axisymmetric angular momentum flux appears which is directed outward (inward) for large (small) magnetic Mach numbers. The internal rotation in a magnetized rotating tank can thus never be uniform. Those particular rotation laws are used to estimate the value of the instability-induced eddy viscosity for which the nondiffusive $\Lambda$ effect and the diffusive shear-induced transport compensate each other. The results provide the Shakura-Sunyaev viscosity ansatz leading to numerical values linearly growing with the Reynolds number of rotation., Comment: 15 pages, 9 figures

Published
2019
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12. The stratorotational instability of Taylor-Couette flows of moderate Reynolds numbers

Author

Rüdiger, G., Seelig, T., Schultz, M., Gellert, M., Harlander, U., and Egbers, Chr.

Subjects
Physics - Fluid Dynamics
Abstract

In view of new experimental data the instability against adiabatic nonaxisymmetric perturbations of a Taylor-Couette flow with an axial density stratification is considered in dependence of the Reynolds number Re of rotation and the Brunt-V\"ais\"al\"a number Rn of the stratification. The flows at and beyond the Rayleigh limit become unstable between a lower and an upper Reynolds number (for fixed Rn). The rotation can thus be too slow or too fast for the stratorotational instability. The upper Reynolds number above which the instability decays, has its maximum value for the potential flow (driven by cylinders rotating according to the Rayleigh limit) and decreases strongly for flatter rotation profiles finally leaving only isolated islands of instability in the (Rn/Re) map. The maximal possible rotation ratio $\mu_{\rm max}$ only slightly exceeds the shear value of the quasi-uniform flow with $U_\phi\simeq$const. Along and between the lines of neutral stability the wave numbers of the instability patterns for all rotation laws beyond the Rayleigh limit are mainly determined by the Froude number Fr which is defined by the ratio between Re and Rn. The cells are highly prolate for Fr>1 so that measurements for too high Reynolds numbers become difficult for axially bounded containers. The instability patterns migrate azimuthally slightly faster than the outer cylinder rotates., Comment: 17 pages, 13 figures, accepted for publishing in JPP

Published
2016
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13. Nonaxisymmetric MHD instabilities of Chandrasekhar states in Taylor-Couette geometry

Author

Gellert, M., Rüdiger, G., Schultz, M., Guseva, A., and Hollerbach, R.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Physics - Fluid Dynamics
Abstract

We consider axially periodic Taylor-Couette geometry with insulating boundary conditions. The imposed basic states are so-called Chandrasekhar states, where the azimuthal flow $U_\phi$ and magnetic field $B_\phi$ have the same radial profiles. Mainly three particular profiles are considered: the Rayleigh limit, quasi-Keplerian, and solid-body rotation. In each case we begin by computing linear instability curves and their dependence on the magnetic Prandtl number Pm. For the azimuthal wavenumber m=1 modes, the instability curves always scale with the Reynolds number and the Hartmann number. For sufficiently small Pm these modes therefore only become unstable for magnetic Mach numbers less than unity, and are thus not relevant for most astrophysical applications. However, modes with m>10 can behave very differently. For sufficiently flat profiles, they scale with the magnetic Reynolds number and the Lundquist number, thereby allowing instability also for the large magnetic Mach numbers of astrophysical objects. We further compute fully nonlinear, three-dimensional equilibration of these instabilities, and investigate how the energy is distributed among the azimuthal (m) and axial (k) wavenumbers. In comparison spectra become steeper for large m, reflecting the smoothing action of shear. On the other hand kinetic and magnetic energy spectra exhibit similar behavior: if several azimuthal modes are already linearly unstable they are relatively flat, but for the rigidly rotating case where m=1 is the only unstable mode they are so steep that neither Kolmogorov nor Iroshnikov-Kraichnan spectra fit the results. The total magnetic energy exceeds the kinetic energy only for large magnetic Reynolds numbers Rm>100., Comment: 12 pages, 14 figures, submitted to ApJ

Published
2016
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14. Biaxial Planar Hall Effect Sensors With Sub-Nanotesla Resolution

Author

Das, P. T., Nhalil, H., Mor, V., Schultz, M., Hasidim, N., Grosz, A., and Klein, L.

Abstract

The planar Hall effect (PHE) magnetic sensors are attractive for various applications, where the field resolution is required in the range of sub-nanotesla or in picotesla. Here, we present a detailed noise study of PHE sensors consisting of two or three intersecting ellipses. It can be used to measure two components of the magnetic field vector in the sensor plane in particular along the two perpendicular easy axes in the overlapping region for two intersecting ellipses and three easy axes at an angle of 60° for three crossing ellipses. Thus, for each remanent magnetic state in the overlap area, the sensor can measure the vector component of the magnetic field perpendicular to the direction of the remanent magnetization. The two field components are measured with a field resolution $\le 200$ pT/ $\surd $ Hz at 10 Hz and 350 pT/ $\surd $ Hz at 1 Hz in the same region, while maintaining a similar size and noise level of a single-axis sensor. Furthermore, we discuss here the possible route for future improvement of the field resolution.

Published
2024
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15. Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study

Author

Robba, C, Battaglini, D, Abbas, A, Sarrió, E, Cinotti, R, Asehnoune, K, Taccone, F, Rocco, P, Schultz, M, Citerio, G, Stevens, R, Badenes, R, Abback, P, Codorniu, A, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garçon, P, Zarka, J, Vermeijden, W, Cornet, A, Gard, S, Domínguez, R, Bellini, M, Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronial, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Companion, B, Pérez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghulam, M, Andrea, C, Daniela, P, Deana, C, Vertigo, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, García-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Mijangos, J, Haënggi, M, Gurjar, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Elbuzidi, A, Piagnerelli, M, Elhadi, M, Digitale, J, Fong, N, Cerda, R, de la Torre Peredo, N, Mccredie, V, Suei, E, Haenggi, M, Samir, J, Robba, Chiara, Battaglini, Denise, Abbas, Abbas, Sarrió, Ezequiel, Cinotti, Raphael, Asehnoune, Karim, Taccone, Fabio S., Rocco, Patricia R., Schultz, Marcus J., Citerio, Giuseppe, Stevens, Robert David, Badenes, Rafael, Abback, Paër-Sélim, Codorniu, Anaïs, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J., Cornet, Alexander Daniel, Gard, Sergio Reyes Infra, Domínguez, Rafael Cirino Lara, Bellini, Maria Mercedes, Haedo, Maria Milagros Gomez, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronial, Arvind, Miranda-Ackerman, Roberto Carlos, Barbosa-Camacho, Francisco José, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Companion, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Yahya, Hana Basheer, Khaled, Ala, Ghulam, Mohamed, Andrea, Cracchiolo Neville, Daniela, Palma Maria, Deana, Cristian, Vertigo, Luigi, Chavez, Manuel J. Rivera, Trujillo, Rocio Mendoza, Legros, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Coombs, Alexander Edward, Welbourne, Jessie, Pineda, Ana Alicia Velarde, Castillo, Víctor Hugo Nubert, Azab, Mohammed A., Azzam, Ahmed Y., van Meenen, David Michael Paul, Gasca, Gilberto Adrian, Arellano, Alfredo, Galicia-Espinosa, Forttino, García-Ramos, José Carlos, Yadav, Ghanshyam, Jha, Amarendra Kumar, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Reza, Syed Tariq, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Mishra, Shakti Bedanta, Samal, Samir, Mijangos, Julio Cesar, Haënggi, Mattias, Gurjar, Mohan, Kaye, Callum, Godoy, Daniela Agustin, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Elbuzidi, Abdurrahmaan Ali Suei, Piagnerelli, Michaël, Elhadi, Muhammed, Azab, Mohammed Atef, Digitale, Jean Catherine, Fong, Nicholas, Cerda, Ricardo Campos, de la Torre Peredo, Norma, McCredie, Victoria, Suei, Elbuzidi Abdurrahmaan Ali, Haenggi, Matthias, Samir, Jaber, Robba, C, Battaglini, D, Abbas, A, Sarrió, E, Cinotti, R, Asehnoune, K, Taccone, F, Rocco, P, Schultz, M, Citerio, G, Stevens, R, Badenes, R, Abback, P, Codorniu, A, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garçon, P, Zarka, J, Vermeijden, W, Cornet, A, Gard, S, Domínguez, R, Bellini, M, Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronial, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Companion, B, Pérez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghulam, M, Andrea, C, Daniela, P, Deana, C, Vertigo, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, García-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Mijangos, J, Haënggi, M, Gurjar, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Elbuzidi, A, Piagnerelli, M, Elhadi, M, Digitale, J, Fong, N, Cerda, R, de la Torre Peredo, N, Mccredie, V, Suei, E, Haenggi, M, Samir, J, Robba, Chiara, Battaglini, Denise, Abbas, Abbas, Sarrió, Ezequiel, Cinotti, Raphael, Asehnoune, Karim, Taccone, Fabio S., Rocco, Patricia R., Schultz, Marcus J., Citerio, Giuseppe, Stevens, Robert David, Badenes, Rafael, Abback, Paër-Sélim, Codorniu, Anaïs, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J., Cornet, Alexander Daniel, Gard, Sergio Reyes Infra, Domínguez, Rafael Cirino Lara, Bellini, Maria Mercedes, Haedo, Maria Milagros Gomez, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronial, Arvind, Miranda-Ackerman, Roberto Carlos, Barbosa-Camacho, Francisco José, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Companion, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Yahya, Hana Basheer, Khaled, Ala, Ghulam, Mohamed, Andrea, Cracchiolo Neville, Daniela, Palma Maria, Deana, Cristian, Vertigo, Luigi, Chavez, Manuel J. Rivera, Trujillo, Rocio Mendoza, Legros, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Coombs, Alexander Edward, Welbourne, Jessie, Pineda, Ana Alicia Velarde, Castillo, Víctor Hugo Nubert, Azab, Mohammed A., Azzam, Ahmed Y., van Meenen, David Michael Paul, Gasca, Gilberto Adrian, Arellano, Alfredo, Galicia-Espinosa, Forttino, García-Ramos, José Carlos, Yadav, Ghanshyam, Jha, Amarendra Kumar, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Reza, Syed Tariq, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Mishra, Shakti Bedanta, Samal, Samir, Mijangos, Julio Cesar, Haënggi, Mattias, Gurjar, Mohan, Kaye, Callum, Godoy, Daniela Agustin, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Elbuzidi, Abdurrahmaan Ali Suei, Piagnerelli, Michaël, Elhadi, Muhammed, Azab, Mohammed Atef, Digitale, Jean Catherine, Fong, Nicholas, Cerda, Ricardo Campos, de la Torre Peredo, Norma, McCredie, Victoria, Suei, Elbuzidi Abdurrahmaan Ali, Haenggi, Matthias, and Samir, Jaber

Abstract

Purpose: The use of arterial partial pressure of carbon dioxide (PaCO2) as a target intervention to manage elevated intracranial pressure (ICP) and its effect on clinical outcomes remain unclear. We aimed to describe targets for PaCO2 in acute brain injured (ABI) patients and assess the occurrence of abnormal PaCO2 values during the first week in the intensive care unit (ICU). The secondary aim was to assess the association of PaCO2 with in-hospital mortality. Methods: We carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO2 was collected on day 1, 3, and 7 from ICU admission. Normocapnia was defined as PaCO2 > 35 and to 45 mmHg; mild hypocapnia as 32–35 mmHg; severe hypocapnia as 26–31 mmHg, forced hypocapnia as < 26 mmHg, and hypercapnia as > 45 mmHg. Results: 1476 patients (65.9% male, mean age 52 ± 18 years) were included. On ICU admission, 804 (54.5%) patients were normocapnic (incidence 1.37 episodes per person/day during ICU stay), and 125 (8.5%) and 334 (22.6%) were mild or severe hypocapnic (0.52 and 0.25 episodes/day). Forced hypocapnia and hypercapnia were used in 40 (2.7%) and 173 (11.7%) patients. PaCO2 had a U-shape relationship with in-hospital mortality with only severe hypocapnia and hypercapnia being associated with increased probability of in-hospital mortality (omnibus p value = 0.0009). Important differences were observed across different subgroups of ABI patients. Conclusions: Normocapnia and mild hypocapnia are common in ABI patients and do not affect patients' outcome. Extreme derangements of PaCO2 values were significantly associated with increased in-hospital mortality.

Published
2024

16. Co-Occurrence of Sarcopenia and Frailty in Acutely Admitted Older Medical Patients:Results from the Copenhagen PROTECT Study

Author

Nygaard, Hanne, Kamper, R. S., Ekmann, A., Hansen, S. K., Hansen, P., Schultz, M., Rasmussen, J., Pressel, E., Suetta, C., Nygaard, Hanne, Kamper, R. S., Ekmann, A., Hansen, S. K., Hansen, P., Schultz, M., Rasmussen, J., Pressel, E., and Suetta, C.

Abstract

Background: Sarcopenia and frailty are often used interchangeably in clinical practice yet represent two distinct conditions and require different therapeutic approaches. The literature regarding the co-occurrence of both conditions in older patients is scarce as most studies have investigated the prevalence of sarcopenia and frailty separately. Objectives: We aim to evaluate the prevalence and co-occurrence of sarcopenia and frailty in a large sample of acutely admitted older medical patients. Design: Secondary analyses using cross-sectional data from the Copenhagen PROTECT study. Setting: Patients were included from the acute medical ward at Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, between November 2019 and November 2021. Participants: Acutely admitted older medical patients (≥65 years). Measurements: Handgrip strength (HGS) was investigated using a handheld dynamometer. Lean mass (SMI) was investigated using direct-segmental multifrequency bioelectrical impedance analyses (DSM-BIA). Low HGS, low SMI, and sarcopenia were defined according to the recent definitions from the European Working Group on Sarcopenia in Older People (EWGSOP2). The Clinical Frailty Scale (CFS) was used to evaluate frailty, with a value > 5 indicating the presence of frailty. Patients were enrolled and tested within 24 hours of admission. Results: This study included 638 patients (mean age: 78.2±7.6, 55% female) with complete records of SMI, HGS, and the CFS. The prevalence of low HGS, low SMI, sarcopenia, and frailty were 39.0%, 33.1%, 19.7%, and 39.0%, respectively. Sarcopenia and frailty co-occurred in 12.1% of the patients. Conclusions: It is well-known that sarcopenia and frailty represent clinical manifestations of ageing and overlap in terms of the impairment in physical function observed in both conditions. Our results demonstrate that sarcopenia and frailty do not necessarily co-occur within the older acutely admitted patient, highlig

Published
2024

17. Subcritical excitation of the current-driven Tayler instability by super-rotation

Author

Rüdiger, G., Schultz, M., Gellert, M., and Stefani, F.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Physics - Fluid Dynamics
Abstract

It is known that in a hydrodynamic Taylor-Couette system uniform rotation or a rotation law with positive shear ('super-rotation') are linearly stable. It is also known that a conducting fluid under the presence of a sufficiently strong axial electric-current becomes unstable against nonaxisymmetric disturbances. It is thus suggestive that a cylindric pinch formed by a homogeneous axial electric-current is stabilized by rotation laws with $d\Omega/dR \geq 0$. However, for magnetic Prandtl numbers Pm$\neq 1$ and for slow rotation also rigid rotation and super-rotation support the instability by lowering their critical Hartmann numbers. For super-rotation in narrow gaps and for modest rotation rates this double-diffusive instability even exists for toroidal magnetic fields with rather arbitrary radial profiles, the current-free profile $B_\phi\propto 1/R$ included. For rigid rotation and for super-rotation the sign of the azimuthal drift of the nonaxisymmetric hydromagnetic instability pattern strongly depends on the magnetic Prandtl number. The pattern counterrotates with the flow for Pm$\ll 1$ and it corotates for Pm$\gg 1$ while for rotation laws with negative shear the instability pattern migrates in the direction of the basic rotation for all Pm. An axial electric-current of minimal 3.6 kAmp flowing inside or outside the inner cylinder suffices to realize the double-diffusive instability for super-rotation in experiments using liquid sodium as the conducting fluid between the rotating cylinders. The limit is 11 kAmp if a gallium alloy is used., Comment: 17 pages, 9 figures, submitted to PoF

Published
2015
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19. The effective magnetic Prandtl number in magnetized and differentially rotating stellar radiation zones

Author

Ruediger, G., Schultz, M., and Kitchatinov, L. L.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

With application to inner stellar radiative zones, a linear theory is used to analyze the instability of a dipole-parity toroidal background field, in the presence of density stratification, differential rotation, and realistically small Prandtl numbers. The physical parameters are the normalized latitudinal shear $a$ and the normalized field amplitude $b$. Only the solutions for the wavelengths with the maximal growth rates are considered. If these scales are combined to the radial values of velocity, one finds that the (very small) radial velocity only depends slightly on $a$ and $b$, so that it can be used as the free parameter of the eigenvalue system. The resulting instability-generated tensors of magnetic diffusivity and eddy viscosity are highly anisotropic. The eddy diffusivity in latitudinal direction exceeds the eddy diffusivity in radial direction by orders of magnitude. Its latitudinal profile shows a strong concentration toward the poles which is also true for the effective viscosity which has been calculated via the angular momentum transport of the instability pattern. The resulting effective magnetic Prandtl number reaches values of $O(10^2)$, so that the differential rotation decays much faster than the toroidal background field, which is {the} necessary condition to explain the observed slow rotation of the early red-giant and sub-giant cores by means of magnetic instabilities., Comment: 10 pages, submitted to MNRAS

Published
2014

21. Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial

Author

Wahlster, S, Sharma, M, Taran, S, Town, J, Stevens, R, Cinotti, R, Asehoune, K, Pelosi, P, Robba, C, Abback, P, Codorniu, A, Citerio, G, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Battaglini, D, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garcon, P, Zarka, J, Vermeijden, W, Cornet, A, Inurrigarro, S, Dominguez, R, Bellini, M, Gomez Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronia, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Compagnon, B, Perez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghula, M, Andrea, C, Daniela, P, Deana, C, Vetrugno, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Velarde Pineda, A, Nubert Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, Garcia-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Mijangos, J, Haenggi, M, Gurjar, M, Schultz, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Badenes, R, Suei Elbuzidi, A, Piagnerelli, M, Elhadi, M, Digitale, J, Fong, N, Cerda, R, de la Torre Peredo, N, Wahlster S., Sharma M., Taran S., Town J. A., Stevens R. D., Cinotti R., Asehoune K., Pelosi P., Robba C., Abback P. -S., Codorniu A., Citerio G., Sala V. L., Astuto M., Tringali E., Alampi D., Rocco M., Maugeri J. G., Bellissima A., Filippini M., Lazzeri N., Cortegiani A., Ippolito M., Battaglini D., Biston P., Al-Gharyani M. F., Chabanne R., Astier L., Soyer B., Gaugain S., Zimmerli A., Pietsch U., Filipovic M., Brandi G., Bicciato G., Serrano A., Monleon B., van Vliet P., Gerretsen B. M., Ortiz-Macias I. X., Oto J., Enomoto N., Matsuda T., Masui N., Garcon P., Zarka J., Vermeijden W. J., Cornet A. D., Inurrigarro S. R., Dominguez R. C. L., Bellini M. M., Gomez Haedo M. M., Lamot L., Orquera J., Biais M., Georges D., Baronia A., Miranda-Ackerman R. C., Barbosa-Camacho F. J., Porter J., Lopez-Morales M., Geeraerts T., Compagnon B., Perez-Torres D., Prol-Silva E., Yahya H. B., Khaled A., Ghula M., Andrea C. N., Daniela P. M., Deana C., Vetrugno L., Chavez M. J. R., Trujillo R. M., Legros V., Brochet B., Huet O., Geslain M., van der Jagt M., van Steenkiste J., Ahmed H., Coombs A. E., Welbourne J., Velarde Pineda A. A., Nubert Castillo V. H., Azab M. A., Azzam A. Y., van Meenen D. M. P., Gasca G. A., Arellano A., Galicia-Espinosa F., Garcia-Ramos J. C., Yadav G., Jha A. K., Robert-Edan V., Rodie-Talbere P. -A., Jain G., Panda S., Agarwal S., Deewan Y., Reza S. T., Hossain M. M., Papadas C., Chantziara V., Sklavou C., Hourmant Y., Grillot N., Pirracchio R., Akkari A., Abdelaty M., Hashim A., Launey Y., Masseret E., Lasocki S., Gergaud S., Mouclier N., Saxena S., Agrawal A., Mishra S. B., Samal S., Mijangos J. C., Haenggi M., Gurjar M., Schultz M. J., Kaye C., Godoy D. A., Alvarez P., Ioakeimidou A., Ueno Y., Badenes R., Suei Elbuzidi A. A., Piagnerelli M., Elhadi M., Digitale J. C., Fong N., Cerda R. C., de la Torre Peredo N., Wahlster, S, Sharma, M, Taran, S, Town, J, Stevens, R, Cinotti, R, Asehoune, K, Pelosi, P, Robba, C, Abback, P, Codorniu, A, Citerio, G, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Battaglini, D, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garcon, P, Zarka, J, Vermeijden, W, Cornet, A, Inurrigarro, S, Dominguez, R, Bellini, M, Gomez Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronia, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Compagnon, B, Perez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghula, M, Andrea, C, Daniela, P, Deana, C, Vetrugno, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Velarde Pineda, A, Nubert Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, Garcia-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Mijangos, J, Haenggi, M, Gurjar, M, Schultz, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Badenes, R, Suei Elbuzidi, A, Piagnerelli, M, Elhadi, M, Digitale, J, Fong, N, Cerda, R, de la Torre Peredo, N, Wahlster S., Sharma M., Taran S., Town J. A., Stevens R. D., Cinotti R., Asehoune K., Pelosi P., Robba C., Abback P. -S., Codorniu A., Citerio G., Sala V. L., Astuto M., Tringali E., Alampi D., Rocco M., Maugeri J. G., Bellissima A., Filippini M., Lazzeri N., Cortegiani A., Ippolito M., Battaglini D., Biston P., Al-Gharyani M. F., Chabanne R., Astier L., Soyer B., Gaugain S., Zimmerli A., Pietsch U., Filipovic M., Brandi G., Bicciato G., Serrano A., Monleon B., van Vliet P., Gerretsen B. M., Ortiz-Macias I. X., Oto J., Enomoto N., Matsuda T., Masui N., Garcon P., Zarka J., Vermeijden W. J., Cornet A. D., Inurrigarro S. R., Dominguez R. C. L., Bellini M. M., Gomez Haedo M. M., Lamot L., Orquera J., Biais M., Georges D., Baronia A., Miranda-Ackerman R. C., Barbosa-Camacho F. J., Porter J., Lopez-Morales M., Geeraerts T., Compagnon B., Perez-Torres D., Prol-Silva E., Yahya H. B., Khaled A., Ghula M., Andrea C. N., Daniela P. M., Deana C., Vetrugno L., Chavez M. J. R., Trujillo R. M., Legros V., Brochet B., Huet O., Geslain M., van der Jagt M., van Steenkiste J., Ahmed H., Coombs A. E., Welbourne J., Velarde Pineda A. A., Nubert Castillo V. H., Azab M. A., Azzam A. Y., van Meenen D. M. P., Gasca G. A., Arellano A., Galicia-Espinosa F., Garcia-Ramos J. C., Yadav G., Jha A. K., Robert-Edan V., Rodie-Talbere P. -A., Jain G., Panda S., Agarwal S., Deewan Y., Reza S. T., Hossain M. M., Papadas C., Chantziara V., Sklavou C., Hourmant Y., Grillot N., Pirracchio R., Akkari A., Abdelaty M., Hashim A., Launey Y., Masseret E., Lasocki S., Gergaud S., Mouclier N., Saxena S., Agrawal A., Mishra S. B., Samal S., Mijangos J. C., Haenggi M., Gurjar M., Schultz M. J., Kaye C., Godoy D. A., Alvarez P., Ioakeimidou A., Ueno Y., Badenes R., Suei Elbuzidi A. A., Piagnerelli M., Elhadi M., Digitale J. C., Fong N., Cerda R. C., and de la Torre Peredo N.

Abstract

Background: There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aimed to describe MP in ventilated patients with ABI, and evaluate associations between MP and clinical outcomes. Methods: In this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult patients with ABI (Glasgow Coma Scale ≤ 12 before intubation) who required mechanical ventilation (MV) ≥ 24 h. Using multivariable log binomial regressions, we separately assessed associations between MP on hospital day (HD)1, HD3, HD7 and clinical outcomes: hospital mortality, need for reintubation, tracheostomy placement, and development of acute respiratory distress syndrome (ARDS). Results: We included 1217 patients (mean age 51.2 years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9 J/min [IQR 9.2–15.1], 13 J/min [IQR 10–17], and 14 J/min [IQR 11–20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9 J/min, aRR at 17 J/min was 1.22, 95% CI 1.14–1.30) and HD3 (1.38, 95% CI 1.23–1.53), reintubation on HD1 (1.64; 95% CI 1.57–1.72), and tracheostomy on HD7 (1

Published
2023

22. Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO Study

Author

Robba, C, Battaglini, D, Cinotti, R, Asehnoune, K, Stevens, R, Taccone, F, Badenes, R, Pelosi, P, Abback, P, Codorniu, A, Citerio, G, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Agrippino, B, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garcon, P, Zarka, J, Vermeijden, W, Cornet, A, Inurrigarro, S, Dominguez, R, Bellini, M, Gomez-Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronia, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Compagnon, B, Perez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghula, M, Cracchiolo Neville, A, Palma, M, Deana, C, Vetrugno, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, Garcia-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Mijangos, J, Haenggi, M, Gurjar, M, Schultz, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Elbuzidi, A, Piagnerelli, M, Elhadi, M, Digitale, J, Fong, N, Cerda, R, de la Torre Peredo, N, Robba C., Battaglini D., Cinotti R., Asehnoune K., Stevens R., Taccone F. S., Badenes R., Pelosi P., Abback P. -S., Codorniu A., Citerio G., Sala V. L., Astuto M., Tringali E., Alampi D., Rocco M., Maugeri J. G., Agrippino B., Filippini M., Lazzeri N., Cortegiani A., Ippolito M., Biston P., Al-Gharyani M. F., Chabanne R., Astier L., Soyer B., Gaugain S., Zimmerli A., Pietsch U., Filipovic M., Brandi G., Bicciato G., Serrano A., Monleon B., van Vliet P., Gerretsen B. M., Ortiz-macias I. X., Oto J., Enomoto N., Matsuda T., Masui N., Garcon P., Zarka J., Vermeijden W. J., Cornet A. D., Inurrigarro S. R., Dominguez R. C. L., Bellini M. M., Gomez-Haedo M. M., Lamot L., Orquera J., Biais M., Georges D., Baronia A., Miranda-Ackerman R. C., Barbosa-Camacho F. J., Porter J., Lopez-Morales M., Geeraerts T., Compagnon B., Perez-Torres D., Prol-Silva E., Yahya H. B., Khaled A., Ghula M., Cracchiolo Neville A., Palma M. D., Deana C., Vetrugno L., Chavez M. J. R., Trujillo R. M., Legros V., Brochet B., Huet O., Geslain M., van der Jagt M., van Steenkiste J., Ahmed H., Coombs A. E., Welbourne J., Pineda A. A. V., Castillo V. H. N., Azab M. A., Azzam A. Y., van Meenen D. M. P., Gasca G. A., Arellano A., Galicia-Espinosa F., Garcia-Ramos J. C., Yadav G., Jha A. K., Robert-Edan V., Rodie-Talbere P. -A., Jain G., Panda S., Agarwal S., Deewan Y., Reza S. T., Hossain M. M., Papadas C., Chantziara V., Sklavou C., Hourmant Y., Grillot N., Pirracchio R., Akkari A., Abdelaty M., Hashim A., Launey Y., Masseret E., Lasocki S., Gergaud S., Mouclier N., Saxena S., Agrawal A., Mishra S. B., Samal S., Mijangos J. C., Haenggi M., Gurjar M., Schultz M. J., Kaye C., Godoy D. A., Alvarez P., Ioakeimidou A., Ueno Y., Elbuzidi A. A. S., Piagnerelli M., Elhadi M., Digitale J. C., Fong N., Cerda R. C., de la Torre Peredo N., Robba, C, Battaglini, D, Cinotti, R, Asehnoune, K, Stevens, R, Taccone, F, Badenes, R, Pelosi, P, Abback, P, Codorniu, A, Citerio, G, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Agrippino, B, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garcon, P, Zarka, J, Vermeijden, W, Cornet, A, Inurrigarro, S, Dominguez, R, Bellini, M, Gomez-Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronia, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Compagnon, B, Perez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghula, M, Cracchiolo Neville, A, Palma, M, Deana, C, Vetrugno, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, Garcia-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Mijangos, J, Haenggi, M, Gurjar, M, Schultz, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Elbuzidi, A, Piagnerelli, M, Elhadi, M, Digitale, J, Fong, N, Cerda, R, de la Torre Peredo, N, Robba C., Battaglini D., Cinotti R., Asehnoune K., Stevens R., Taccone F. S., Badenes R., Pelosi P., Abback P. -S., Codorniu A., Citerio G., Sala V. L., Astuto M., Tringali E., Alampi D., Rocco M., Maugeri J. G., Agrippino B., Filippini M., Lazzeri N., Cortegiani A., Ippolito M., Biston P., Al-Gharyani M. F., Chabanne R., Astier L., Soyer B., Gaugain S., Zimmerli A., Pietsch U., Filipovic M., Brandi G., Bicciato G., Serrano A., Monleon B., van Vliet P., Gerretsen B. M., Ortiz-macias I. X., Oto J., Enomoto N., Matsuda T., Masui N., Garcon P., Zarka J., Vermeijden W. J., Cornet A. D., Inurrigarro S. R., Dominguez R. C. L., Bellini M. M., Gomez-Haedo M. M., Lamot L., Orquera J., Biais M., Georges D., Baronia A., Miranda-Ackerman R. C., Barbosa-Camacho F. J., Porter J., Lopez-Morales M., Geeraerts T., Compagnon B., Perez-Torres D., Prol-Silva E., Yahya H. B., Khaled A., Ghula M., Cracchiolo Neville A., Palma M. D., Deana C., Vetrugno L., Chavez M. J. R., Trujillo R. M., Legros V., Brochet B., Huet O., Geslain M., van der Jagt M., van Steenkiste J., Ahmed H., Coombs A. E., Welbourne J., Pineda A. A. V., Castillo V. H. N., Azab M. A., Azzam A. Y., van Meenen D. M. P., Gasca G. A., Arellano A., Galicia-Espinosa F., Garcia-Ramos J. C., Yadav G., Jha A. K., Robert-Edan V., Rodie-Talbere P. -A., Jain G., Panda S., Agarwal S., Deewan Y., Reza S. T., Hossain M. M., Papadas C., Chantziara V., Sklavou C., Hourmant Y., Grillot N., Pirracchio R., Akkari A., Abdelaty M., Hashim A., Launey Y., Masseret E., Lasocki S., Gergaud S., Mouclier N., Saxena S., Agrawal A., Mishra S. B., Samal S., Mijangos J. C., Haenggi M., Gurjar M., Schultz M. J., Kaye C., Godoy D. A., Alvarez P., Ioakeimidou A., Ueno Y., Elbuzidi A. A. S., Piagnerelli M., Elhadi M., Digitale J. C., Fong N., Cerda R. C., and de la Torre Peredo N.

Abstract

Background: In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with ABI during the intensive care unit (ICU) stay and to determine their association with in-hospital mortality. The secondary aim was to identify the optimal thresholds of arterial partial pressure of oxygen (PaO2) predicting in-hospital mortality. Methods: We conducted a secondary analysis of a prospective multicenter observational cohort study. Adult patients with ABI (traumatic brain injury, subarachnoid aneurysmal hemorrhage, intracranial hemorrhage, ischemic stroke) with available data on PaO2 during the ICU stay were included. Hypoxemia was defined as PaO2 < 80 mm Hg, normoxemia was defined as PaO2 between 80 and 120 mm Hg, mild/moderate hyperoxemia was defined as PaO2 between 121 and 299 mm Hg, and severe hyperoxemia was defined as PaO2 levels ≥ 300 mm Hg. Results: A total of 1,407 patients were included in this study. The mean age was 52 (±18) years, and 929 (66%) were male. Over the ICU stay, the fractions of patients in the study cohort who had at least one episode of hypoxemia, mild/moderate hyperoxemia, and severe hyperoxemia were 31.3%, 53.0%, and 1.7%, respectively. PaO2 values below 92 mm Hg and above 156 mm Hg were associated with an increased probability of in-hospital mortality. Differences were observed among subgroups of patients with ABI, with consistent effects only seen in patients without traumatic brain injury. Conclusions: In patients with ABI, hypoxemia and mild/moderate hyperoxemia were relatively frequent. Hypoxemia and hyperoxemia during ICU stay may influence in-hospital mortality. However, the small number of oxygen values collected represents a major limitation of the study.

Published
2023

23. Risk factors of extubation failure in neurocritical patients with the most impaired consciousness

Author

de Courson, H, Massart, N, Asehnoune, K, Cinotti, R, Abback, P, Codorniu, A, Citerio, G, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Robba, C, Battaglini, D, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garcon, P, Zarka, J, Vermeijden, W, Cornet, A, Inurrigarro, S, Dominguez, R, Bellini, M, Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronia, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Compagnon, B, Perez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghula, M, Andrea, C, Daniela, P, Deana, C, Vetrugno, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espino-sa, F, Garcia-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Fong, N, Digitale, J, Stevens, R, Mijangos, J, Haenngi, M, Gurjar, M, Schultz, M, Godoy, D, Alvarez, P, Kaye, C, Ioakeimidou, A, Ueno, Y, Badenes, R, Elbuzidi, A, Piagnerelli, M, Elhadi, M, Cerda, R, Peredo, N, de Courson H., Massart N., Asehnoune K., Cinotti R., Abback P. -S., Codorniu A., Citerio G., Sala V. L., Astuto M., Tringali E., Alampi D., Rocco M., Maugeri J. G., Bellissima A., Filippini M., Lazzeri N., Cortegiani A., Ippolito M., Robba C., Battaglini D., Biston P., Al-Gharyani M. F., Chabanne R., Astier L., Soyer B., Gaugain S., Zimmerli A., Pietsch U., Filipovic M., Brandi G., Bicciato G., Serrano A., Monleon B., van Vliet P., Gerretsen B. M., Ortiz-Macias I. X., Oto J., Enomoto N., Matsuda T., Masui N., Garcon P., Zarka J., Vermeijden W. J., Cornet A. D., Inurrigarro S. R., Dominguez R. C. L., Bellini M. M., Haedo M. M. G., Lamot L., Orquera J., Biais M., Georges D., Baronia A., Miranda-Ackerman R. C., Barbosa-Camacho F. J., Porter J., Lopez-Morales M., Geeraerts T., Compagnon B., Perez-Torres D., Prol-Silva E., Yahya H. B., Khaled A., Ghula M., Andrea C. N., Daniela P. M., Deana C., Vetrugno L., Chavez M. J. R., Trujillo R. M., Legros V., Brochet B., Huet O., Geslain M., van der Jagt M., van Steenkiste J., Ahmed H., Coombs A. E., Welbourne J., Pineda A. A. V., Castillo V. H. N., Azab M. A., Azzam A. Y., van Meenen D. M. P., Gasca G. A., Arellano A., Galicia-Espino-sa F., Garcia-Ramos J. C., Yadav G., Jha A. K., Robert-Edan V., Rodie-Talbere P. -A., Jain G., Panda S., Agarwal S., Deewan Y., Reza S. T., Hossain M. M., Papadas C., Chantziara V., Sklavou C., Hourmant Y., Grillot N., Pirracchio R., Akkari A., Abdelaty M., Hashim A., Launey Y., Masseret E., Lasocki S., Gergaud S., Mouclier N., Saxena S., Agrawal A., Mishra S. B., Samal S., Fong N., Digitale J., Stevens R., Mijangos J. C., Haenngi M., Gurjar M., Schultz M., Godoy D. A., Alvarez P., Kaye C., Ioakeimidou A., Ueno Y., Badenes R., Elbuzidi A. S., Piagnerelli M., Elhadi M., Cerda R., Peredo N., de Courson, H, Massart, N, Asehnoune, K, Cinotti, R, Abback, P, Codorniu, A, Citerio, G, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Robba, C, Battaglini, D, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garcon, P, Zarka, J, Vermeijden, W, Cornet, A, Inurrigarro, S, Dominguez, R, Bellini, M, Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronia, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Compagnon, B, Perez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghula, M, Andrea, C, Daniela, P, Deana, C, Vetrugno, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azab, M, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espino-sa, F, Garcia-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Reza, S, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Fong, N, Digitale, J, Stevens, R, Mijangos, J, Haenngi, M, Gurjar, M, Schultz, M, Godoy, D, Alvarez, P, Kaye, C, Ioakeimidou, A, Ueno, Y, Badenes, R, Elbuzidi, A, Piagnerelli, M, Elhadi, M, Cerda, R, Peredo, N, de Courson H., Massart N., Asehnoune K., Cinotti R., Abback P. -S., Codorniu A., Citerio G., Sala V. L., Astuto M., Tringali E., Alampi D., Rocco M., Maugeri J. G., Bellissima A., Filippini M., Lazzeri N., Cortegiani A., Ippolito M., Robba C., Battaglini D., Biston P., Al-Gharyani M. F., Chabanne R., Astier L., Soyer B., Gaugain S., Zimmerli A., Pietsch U., Filipovic M., Brandi G., Bicciato G., Serrano A., Monleon B., van Vliet P., Gerretsen B. M., Ortiz-Macias I. X., Oto J., Enomoto N., Matsuda T., Masui N., Garcon P., Zarka J., Vermeijden W. J., Cornet A. D., Inurrigarro S. R., Dominguez R. C. L., Bellini M. M., Haedo M. M. G., Lamot L., Orquera J., Biais M., Georges D., Baronia A., Miranda-Ackerman R. C., Barbosa-Camacho F. J., Porter J., Lopez-Morales M., Geeraerts T., Compagnon B., Perez-Torres D., Prol-Silva E., Yahya H. B., Khaled A., Ghula M., Andrea C. N., Daniela P. M., Deana C., Vetrugno L., Chavez M. J. R., Trujillo R. M., Legros V., Brochet B., Huet O., Geslain M., van der Jagt M., van Steenkiste J., Ahmed H., Coombs A. E., Welbourne J., Pineda A. A. V., Castillo V. H. N., Azab M. A., Azzam A. Y., van Meenen D. M. P., Gasca G. A., Arellano A., Galicia-Espino-sa F., Garcia-Ramos J. C., Yadav G., Jha A. K., Robert-Edan V., Rodie-Talbere P. -A., Jain G., Panda S., Agarwal S., Deewan Y., Reza S. T., Hossain M. M., Papadas C., Chantziara V., Sklavou C., Hourmant Y., Grillot N., Pirracchio R., Akkari A., Abdelaty M., Hashim A., Launey Y., Masseret E., Lasocki S., Gergaud S., Mouclier N., Saxena S., Agrawal A., Mishra S. B., Samal S., Fong N., Digitale J., Stevens R., Mijangos J. C., Haenngi M., Gurjar M., Schultz M., Godoy D. A., Alvarez P., Kaye C., Ioakeimidou A., Ueno Y., Badenes R., Elbuzidi A. S., Piagnerelli M., Elhadi M., Cerda R., and Peredo N.

Published
2023

24. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Author

Matuozzo, D, Talouarn, E, Marchal, A, Zhang, P, Manry, J, Seeleuthner, Y, Zhang, Y, Bolze, A, Chaldebas, M, Milisavljevic, B, Gervais, A, Bastard, P, Asano, T, Bizien, L, Barzaghi, F, Abolhassani, H, Abou Tayoun, A, Aiuti, A, Alavi Darazam, I, Allende, L, Alonso-Arias, R, Arias, A, Aytekin, G, Bergman, P, Bondesan, S, Bryceson, Y, Bustos, I, Cabrera-Marante, O, Carcel, S, Carrera, P, Casari, G, Chaibi, K, Colobran, R, Condino-Neto, A, Covill, L, Delmonte, O, El Zein, L, Flores, C, Gregersen, P, Gut, M, Haerynck, F, Halwani, R, Hancerli, S, Hammarstrom, L, Hatipoglu, N, Karbuz, A, Keles, S, Kyheng, C, Leon-Lopez, R, Franco, J, Mansouri, D, Martinez-Picado, J, Metin Akcan, O, Migeotte, I, Morange, P, Morelle, G, Martin-Nalda, A, Novelli, G, Novelli, A, Palabiyik, F, Pan-Hammarstrom, Q, de Diego, R, Planas-Serra, L, Pleguezuelo, D, Prando, C, Pujol, A, Reyes, L, Riviere, J, Rodriguez-Gallego, C, Rojas, J, Rovere-Querini, P, Schluter, A, Shahrooei, M, Sobh, A, Soler-Palacin, P, Tandjaoui-Lambiotte, Y, Tipu, I, Tresoldi, C, Troya, J, van de Beek, D, Zatz, M, Zawadzki, P, Al-Muhsen, S, Alosaimi, M, Alsohime, F, Baris-Feldman, H, Butte, M, Constantinescu, S, Cooper, M, Dalgard, C, Fellay, J, Heath, J, Lau, Y, Lifton, R, Maniatis, T, Mogensen, T, von Bernuth, H, Lermine, A, Vidaud, M, Boland, A, Deleuze, J, Nussbaum, R, Kahn-Kirby, A, Mentre, F, Tubiana, S, Gorochov, G, Tubach, F, Hausfater, P, Al-Mulla, F, Anderson, M, Andreakos, E, Feldman, H, Belot, A, Biggs, C, Bogunovic, D, Bondarenko, A, Bousfiha, A, Brodin, P, Bustamante, C, Chakravorty, S, Christodoulou, J, Desai, M, Drolet, B, Baghdadi, J, Espinosa-Padilla, S, Froidure, A, Hagin, D, Henrickson, S, Hsieh, E, Husebye, E, Imai, K, Itan, Y, Jarvis, E, Karamitros, T, Kisand, K, Ku, C, Ling, Y, Lucas, C, Marodi, L, Milner, J, Mironska, K, Morio, T, Ng, L, O'Farrelly, C, Okada, S, Planas, A, Quintana-Murci, L, Renia, L, Resnick, I, Sancho-Shimizu, V, Sediva, A, Seppanen, M, Shcherbina, A, Slaby, O, Snow, A, Spaan, A, Tancevski, I, Tangye, S, Ramaswamy, S, Turvey, S, Uddin, F, Uddin, M, Vinh, D, Casanova, J, Vacher, Y, Gysembergh-Houal, A, Demerville, L, Chachoua, A, Abad, S, Abassi, R, Abdellaoui, A, Abdelmalek, A, Abdoul, H, Abergel, H, Abeud, F, Abgrall, S, Abisror, N, Adechian, M, Aderdour, N, Admane, H, Adnet, F, Afritt, S, Agostini, H, Aguilar, C, Agut, S, Aiello, T, Kaci, M, Oufella, H, Ajeenthiravasan, G, Alauzy, V, Alby-Laurent, F, Allard, L, Alyanakian, M, Borrero, B, Amam, S, Amrouche, L, Andronikof, M, Anglicheau, D, Anguel, N, Annane, D, Aounzou, M, Aparicio, C, Aratus, G, Arlet, J, Arzoine, J, Aslangul, E, Assefi, M, Aubry, A, Audiffred, L, Audureau, E, Auger, C, Auregan, J, Awotar, C, Milla, S, Azan, D, Azemar, L, Azzouguen, B, Elrufaai, M, Badsi, A, Bakouboula, P, Balcerowiak, C, Balde, F, Baldivia, E, Bangamingo, E, Baptiste, A, Baran-Marszak, F, Barau, C, Barget, N, Baronnet, F, Barthelemy, R, Baudel, J, Baudry, C, Baudry, E, Beaugerie, L, Belamri, A, Belaube, N, Belilita, R, Bellassen, P, Belmokhtar, R, Beltran, I, Benainous, R, Benallaoua, M, Benamouzig, R, Benbara, A, Benhida, J, Benkhelouf, A, Benlagha, J, Benmostafa, C, Benothmane, S, Bentifraouine, M, Berard, L, Bernier, Q, Berti, E, Bertier, A, Berton, L, Bessis, S, Beurton, A, Bianco, C, Bianquis, C, Bidar, F, Blanche, P, Blayau, C, Bleibtreu, A, Blin, E, Bloch-Queyrat, C, Boissier, M, Bollens, D, Bolzoni, M, Bompard, R, Bonnet, N, Bonnouvrier, J, Botha, S, Boucenna, W, Bouchama, F, Bouchaud, O, Bouchghoul, H, Boudjebla, T, Boudjema, N, Bouffard, C, Bougle, A, Bouguerra, M, Bouras, L, Bourcier, A, Durand, A, Bourrier, A, Bouscarat, F, Bouvry, D, Bouziri, N, Bouzrara, O, Bribier, S, Brugier, D, Brunel, M, Bui, E, Buisson, A, Bukreyeva, I, Bureau, C, Cadranel, J, Cailhol, J, Calin, R, Vega, C, Canavaggio, P, Cancella, M, Cantin, D, Cao, A, Carbillon, L, Carlier, N, Cassard, C, Castor, G, Cauchy, M, Cha, O, Chaigne, B, Challal, S, Champion, K, Chariot, P, Chas, J, Chauveau, S, Chauvin, A, 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B., Bourrier A., Bouscarat F., Bouvry D., Bouziri N., Bouzrara O., Bribier S., Brugier D., Brunel M., Bui E., Buisson A., Bukreyeva I., Bureau C., Cadranel J., Cailhol J., Calin R., Vega C. C., Canavaggio P., Cancella M., Cantin D., Cao A., Carbillon L., Carlier N., Cassard C., Castor G., Cauchy M., Cha O., Chaigne B., Challal S., Champion K., Chariot P., Chas J., Chauveau S., Chauvin A., Chauvin C., Chavarot N., Chebbout K., Cherai M., Cherubini I., Chevalier A., Chiarabini T., Chinet T., Chocron R., Choinier P., Chommeloux J., Choquet C., Choupeaux L., Chousterman B., Ciocan D., Clarke A., Clavere G., Clavier F., Clement K., Clerc S., Cohen Y., Cohen F., Cohen A., Coilly A., Colboc H., Colin P., Collet M., Comarmond C., Combacon E., Combes A., Comparon C., Constantin J. -M., Cordel H., Cordier A. -G., Costantini A., Chalumeau N. C., Couffignal C., Coupeau D., Creange A., Lamarre Y. C., Da Silveira C., Kayani S. D. G. 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M., Smith N., Solanich X., Sole-Violan J., Soler C., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Trouillet-Assant S., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Oz S. K. T., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Veliz S. P. Z., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Volokha A., Vuotto F., Wauters E., Wauters J., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Boulanger C., Vanderlinden D., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Cloherty O. C. A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geijtenbeek S. G. T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Heunks S. M. H. L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Danielson J. J., Biondi A., Bettini L. R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Meyts I., Zhang S. -Y., Puel A., Notarangelo L. D., Boisson-Dupuis S., Su H. C., Boisson B., Jouanguy E., Zhang Q., Abel L., and Cobat A.

Abstract

Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

Published
2023

25. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

Author

Pham, T, Heunks, L, Bellani, G, Madotto, F, Aragao, I, Beduneau, G, Goligher, E, Grasselli, G, Laake, J, Mancebo, J, Penuelas, O, Piquilloud, L, Pesenti, A, Wunsch, H, van Haren, F, Brochard, L, Laffey, J, Abrough, F, Acharya, S, Amin, P, Arabi, Y, Bauer, P, Beitler, J, Berkius, J, Bugedo, G, Camporota, L, Cerny, V, Cho, Y, Clarkson, K, Estenssoro, E, Gritsan, A, Hashemian, S, Hermans, G, Jovanovic, B, Kurahashi, K, Matamis, D, Moerer, O, Molnar, Z, Ozyilmaz, E, Panka, B, Papali, A, Perbet, S, Qiu, H, Razek, A, Rittayamai, N, Roldan, R, Serpa Neto, A, Szuldrzynski, K, Talmor, D, Tomescu, D, Villagomez, A, Zeggwagh, A, Abe, T, Aboshady, A, Acampo-de Jong, M, Adderley, J, Adiguzel, N, Agrawal, V, Aguilar, G, Aguirre, G, Aguirre-Bermeo, H, Ahlstrom, B, Akbas, T, Akker, M, Al Sadeh, G, Alamri, S, Algaba, A, Ali, M, Aliberti, A, Allegue, J, Alvarez, D, Amador, J, Andersen, F, Ansari, S, Apichatbutr, Y, Apostolopoulou, O, Arellano, D, Arica, M, Arikan, H, Arinaga, K, Arnal, J, Asano, K, Asin-Corrochano, M, Avalos Cabrera, J, Avila Fuentes, S, Aydemir, S, Aygencel, G, Azevedo, L, Bacakoglu, F, Badie, J, Baedorf Kassis, E, Bai, G, Balaraj, G, Ballico, B, Banner-Goodspeed, V, Banwarie, P, Barbieri, R, Baronia, A, Barrett, J, Barrot, L, Barrueco-Francioni, J, Barry, J, Bawangade, H, Beavis, S, Beck, E, Beehre, N, Belenguer Muncharaz, A, Belliato, M, Bellissima, A, Beltramelli, R, Ben Souissi, A, Benitez-Cano, A, Benlamin, M, Benslama, A, Bento, L, Benvenuti, D, Bernabe, L, Bersten, A, Berta, G, Bertini, P, Bertram-Ralph, E, Besbes, M, Bettini, L, Beuret, P, Bewley, J, Bezzi, M, Bhakhtiani, L, Bhandary, R, Bhowmick, K, Bihari, S, Bissett, B, Blythe, D, Bocher, S, Boedjawan, N, Bojanowski, C, Boni, E, Boraso, S, Borelli, M, Borello, S, Borislavova, M, Bosma, K, Bottiroli, M, Boyd, O, Bozbay, S, Briva, A, Bruel, C, Bruni, A, Buehner, U, Bulpa, P, Burt, K, Buscot, M, Buttera, S, Cabrera, J, Caccese, R, Caironi, P, Canchos Gutierrez, I, Canedo, N, Cani, A, Cappellini, I, 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N., Crespo Ramirez M., Crova P., Cruz J., Cubattoli L., Cukurova Z., Curto F., Czempik P., D'Andrea R., da Silva Ramos F., Dangers L., Danguy des Deserts M., Danin P. -E., Dantas F., Daubin C., Dawei W., de Haro C., de Jesus Montelongo F., De Mendoza D., de Pablo R., De Pascale G., De Rosa S., Decavele M., Declercq P. -L., Deicas A., del Carmen Campos Moreno M., Dellamonica J., Delmas B., Demirkiran O., Demirkiran H., Dendane T., di Mussi R., Diakaki C., Diaz A., Diaz W., Dikmen Y., Dimoula A., Doble P., Doha N., Domingos G., Dres M., Dries D., Duggal A., Duke G., Dunts P., Dybwik K., Dykyy M., Eckert P., Efe S., Elatrous S., Elay G., Elmaryul A. S., Elsaadany M., Elsayed H., Elsayed S., Emery M., Ena S., Eng K., Englert J. A., Erdogan E., Ergin Ozcan P., Eroglu E., Escobar M., Esen F., Esen Tekeli A., Esquivel A., Esquivel Gallegos H., Ezzouine H., Facchini A., Faheem M., Fanelli V., Farina M. F., Fartoukh M., Fehrle L., Feng F., Feng Y., Fernandez I., Fernandez B., Fernandez-Rodriguez M. L., Ferrando C., Ferreira da Silva M. J., Ferreruela M., Ferrier J., Flamm Zamorano M. J., Flood L., Floris L., Fluckiger M., Forteza C., Fortunato A., Frans E., Frattari A., Fredes S., Frenzel T., Fumagalli R., Furche M. A., Fusari M., Fysh E., Galeas-Lopez J. L., Galerneau L. -M., Garcia A., Garcia M. F., Garcia E., Garcia Olivares P., Garlicki J., Garnero A., Garofalo E., Gautam P., Gazenkampf A., Gelinotte S., Gelormini D., Ghrenassia E., Giacomucci A., Giannoni R., Gigante A., Glober N., Gnesin P., Gollo Y., Gomaa D., Gomero Paredes R., Gomes R., Gomez R. A., Gomez O., Gomez A., Gondim L., Gonzalez M., Gonzalez I., Gonzalez-Castro A., Gordillo Romero O., Gordo F., Gouin P., Graf Santos J., Grainne R., Grando M., Granov Grabovica S., Grasso S., Grasso R., Grimmer L., Grissom C., Gu Q., Guan X. -D., Guarracino F., Guasch N., Guatteri L., Gueret R., Guerin C., Guerot E., Guitard P. -G., Gul F., Gumus A., Gurjar M., Gutierrez P., Hachimi A., Hadzibegovic A., Hagan S., Hammel C., Han Song J., Hanlon G., Heines S., Henriksson J., Herbrecht J. -E., Heredia Orbegoso G. O., Hermon A., Hernandez R., Hernandez C., Herrera L., Herrera-Gutierrez M., Hidalgo J., Hill D., Holmquist D., Homez M., Hongtao X., Hormis A., Horner D., Hornos M. C., Hou M., House S., Housni B., Hugill K., Humphreys S., Humbert L., Hunter S., Hwa Young L., Iezzi N., Ilutovich S., Inal V., Innes R., Ioannides P., Iotti G. A., Ippolito M., Irie H., Iriyama H., Itagaki T., Izura J., Izza S., Jabeen R., Jamaati H., Jamadarkhana S., Jamoussi A., Jankowski M., Jaramillo L. 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C., Wei B. -L., Weller D., Welsh D., Welters I., Wert M., Whiteley S., Wilby E., Williams E., Williams K., Wilson A., Wojtas J., Won Huh J., Wrathall D., Wright C., Wu J. -F., Xi G., Xing Z. -J., Xu H., Yamamoto K., Yan J., Yanez J., Yang X., Yates E., Yazicioglu Mocin O., Ye Z., Yildirim F., Yoshida N., Yoshido H. H. L., Young Lee B., Yu R., Yu G., Yu T., Yuan B., Yuangtrakul N., Yumoto T., Yun X., Zakalik G., Zaki A., Zalba-Etayo B., Zambon M., Zang B., Zani G., Zarka J., Zerbi S. M., Zerman A., Zetterquist H., Zhang J., Zhang H., Zhang W., Zhang G., Zhao H., Zheng J., Zhu B., and Zumaran R.

Abstract

Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 d

Published
2023

26. Astrophysical and experimental implications from the magnetorotational instability of toroidal fields

Author

Ruediger, G., Gellert, M., Schultz, M., Hollerbach, R., and Stefani, F.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Physics - Fluid Dynamics
Abstract

The interaction of differential rotation and toroidal fields that are current-free in the gap between two corotating axially unbounded cylinders is considered. It is shown that nonaxisymmetric perturbations are unstable if the rotation rate and Alfv\'en frequency of the field are of the same order, almost independent of the magnetic Prandtl number Pm. For the very steep rotation law \Omega\propto R^{-2} (the Rayleigh limit) and for small Pm the threshold values of rotation and field for this Azimuthal MagnetoRotational Instability (AMRI) scale with the ordinary Reynolds number and the Hartmann number, resp. A laboratory experiment with liquid metals like sodium or gallium in a Taylor-Couette container has been designed on the basis of this finding. For fluids with more flat rotation laws the Reynolds number and the Hartmann number are no longer typical quantities for the instability. For the weakly nonlinear system the numerical values of the kinetic energy and the magnetic energy are derived for magnetic Prandtl numbers \leq 1. We find that the magnetic energy grows monotonically with the magnetic Reynolds number Rm, while the kinetic energy grows with Rm/\sqrt{Pm}. The resulting turbulent Schmidt number, as the ratio of the `eddy' viscosity and the diffusion coefficient of a passive scalar (such as lithium) is of order 20 for Pm=1, but for small Pm it drops to order unity. Hence, in a stellar core with fossil fields and steep rotation law the transport of angular momentum by AMRI is always accompanied by an intense mixing of the plasma, until the rotation becomes rigid., Comment: 8 pages, 11 figures

Published
2013
Full Text
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27. Characterisation of Teacher Professional Knowledge and Skill through Content Representations from Tertiary Chemistry Educators

Author

Schultz, M., Lawrie, G. A., Bailey, C. H., and Dargaville, B. L.

Abstract

An established tool for collating secondary teachers' pedagogical content knowledge (Loughran's CoRe) has been adapted for use by tertiary educators. Chemistry lecturers with a range of levels of experience were invited to participate in workshops through which the tool was piloted, refined and applied. We now present this refined tool for the tertiary teaching community to consider adopting. The teaching approaches of over 80 workshop participants were collected using the tool in a broad survey of tertiary chemistry teaching strategies. Participation in the workshops led to a significant gain in personal PCK for some individuals. Analysis of responses received in the workshops revealed that the consensus model of secondary teacher professional knowledge and skill is also applicable to the tertiary level, and that the CoRe is a useful way to gain insight into the knowledge bases and topic-specific professional knowledge of tertiary chemistry teachers. The data were aggregated and coded inductively to distil the types of strategies commonly found to be useful for teaching particular tertiary chemistry topics. This resulted in collation of over 300 teaching strategies for 19 different chemistry topics, representing significant topic-specific professional knowledge of tertiary practitioners. To share and sustain this collection of teaching strategies, a website was built that is searchable by either chemistry topic or by type of teaching strategy, making it immediately useful to practitioners. Usage analytics data for the website confirm that many users have accessed the resource, showing that this is a practical way to transfer information between chemistry educators.

Published
2018
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28. Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: clinical indicators

Author

Myles, P., Grocott, M., Biccard, B., Blazeby, J., Boney, O., Chan, M., Diouf, E., Fleisher, L., Kalkman, C., Kurz, A., Moonesinghe, R., Wijeysundera, D., Gan, T.J., Peyton, P., Sessler, D., Tramèr, M., Cyna, A., De Oliveira, G.S., Jr., Wu, C., Jensen, M., Kehlet, H., Botti, M., Haller, G., Cook, T., Neuman, M., Story, D., Gruen, R., Bampoe, S., Evered, L., Scott, D., Silbert, B., van Dijk, D., Grocott, H., Eckenhoff, R., Rasmussen, L., Eriksson, L., Beattie, S., Landoni, G., Leslie, K., Howell, S., Nagele, P., Richards, T., Lamy, A., Lalu, M., Pearse, R., Mythen, M., Canet, J., Moller, A., Gin, T., Schultz, M., Pelosi, P., Gabreu, M., Futier, E., Creagh-Brown, B., Abbott, T., Klein, A., Corcoran, T., Jamie Cooper, D., Dieleman, S., McIlroy, D., Bellomo, R., Shaw, A., Prowle, J., Karkouti, K., Billings, J., Mazer, D., Jayarajah, M., Murphy, M., Bartoszko, J., Sneyd, R., Morris, S., George, R., Shulman, M., Lane-Fall, M., Nilsson, U., Stevenson, N., Cooper, J.D.J., van Klei, W., Cabrini, L., Miller, T., Pace, N., Jackson, S., Buggy, D., Short, T., Riedel, B., Gottumukkala, V., Alkhaffaf, B., Johnson, M., Haller, Guy, Bampoe, Sohail, Cook, Tim, Fleisher, Lee A., Grocott, Michael P.W., Neuman, Mark, Story, David, and Myles, Paul S.

Published
2019
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29. Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications

Author

Kroell, W., Metzler, H., Struber, G., Wegscheider, T., Gombotz, H., Hiesmayr, M., Schmid, W., Urbanek, B., Kahn, D., Momeni, M., Pospiech, A., Lois, F., Forget, P., Grosu, I., Poelaert, J., Mossevelde, V., van Malderen, M.C., Dylst, D., Melkebeek, J.V., Beran, M., Hert, S.D., Baerdemaeker, L.D., Heyse, B., Limmen, J.V., Wyffels, P., Jacobs, T., Roels, N., Bruyne, A.D., Velde, S.V.D., Marina, J.Z., Dejana, D.O., Pernar, S., Zunic, J., Miskovic, P., Zilic, A., Kvolik, S., Ivic, D., Darija, A.V., Skiljic, S., Vinkovic, H., Oputric, I., Juricic, K., Frkovic, V., Kopic, J., Mirkovic, I., Saric, J.P., Erceg, G., Dvorscak, M.B., Branka, M.S., Pavicic, A.M., Goranovic, T., Maldini, B., Radocaj, T., Gavranovic, Z., Inga, M.B., Sehovic, M., Stourac, P., Harazim, H., Smekalova, O., Kosinova, M., Kolacek, T., Hudacek, K., Drab, M., Brujevic, J., Vitkova, K., Jirmanova, K., Volfova, I., Dzurnakova, P., Liskova, K., Dudas, R., Filipsky, R., Kafrawy, S.E., Abdelwahab, H.H., Metwally, T., Ahmed, A.R., Ahmed Mostafa, E.S., Hasan, W.F., Ahmed, A.G., Yassin, H., Magdy, M., Abdelhady, M., Mahran, M., Herodes, E., Kivik, P., Oganjan, J., Aun, A., Sormus, A., Sarapuu, K., Mall, M., Karjagin, J., Futier, E., Petit, A., Gerard, A., Marret, E., Solier, M., Jaber, S., Prades, A., Krassler, J., Merzky, S., Abreu, M.G.D., Uhlig, C., Kiss, T., Bundy, A., Bluth, T., Gueldner, A., Spieth, P., Scharffenberg, M., Thiem, D.T., Koch, T., Treschan, T., Schaefer, M., Bastin, B., Geib, J., Weiss, M., Kienbaum, P., Pannen, B., Gottschalk, A., Konrad, M., Westerheide, D., Schwerdtfeger, B., Wrigge, H., Simon, P., Reske, A., Nestler, C., Valsamidis, D., Stroumpoulis, K., Antholopoulos, G., Andreou, A., Karapanos, D., Theodoraki, K., Gkiokas, G., Tasoulis, M.K., Sidiropoulou, T., Zafeiropoulou, F., Florou, P., Pandazi, A., Tsaousi, G., Nouris, C., Pourzitaki, C., Bystritski, D., Pizov, R., Eden, A., Pesce, C.V., Campanile, A., Marrella, A., Grasso, S., Michele, M.D., Bona, F., Giacoletto, G., Sardo, E., Sottosanti, L.G.V., Solca, M., Volta, C.A., Spadaro, S., Verri, M., Ragazzi, R., Zoppellari, R., Cinnella, G., Raimondo, P., Bella, D.L., Mirabella, L., D'antini, D., Pelosi, P., Molin, A., Brunetti, I., Gratarola, A., Pellerano, G., Sileo, R., Pezzatto, S., Montagnani, L., Pasin, L., Landoni, G., Zangrillo, A., Beretta, L., Parma, A.L.D., Tarzia, V., Dossi, R., Sassone, M.E., Sances, D., Tredici, S., Spano, G., Castellani, G., Delunas, L., Peradze, S., Venturino, M., Arpino, I., Sher, S., Tommasino, C., Rapido, F., Morelli, P., Vargas, M., Servillo, G., Cortegiani, A., Raineri, S.M., Montalto, F., Russotto, V., Giarratano, A., Baciarello, M., Generali, M., Cerati, G., Leykin, Y., Bressan, F., Bartolini, V., Zamidei, L., Brazzi, L., Liperi, C., Sales, G., Pistidda, L., Severgnini, P., Brugnoni, E., Musella, G., Bacuzzi, A., Muhardri, D., Agreta, G.G., Sada, F., Bytyqi, A., Karbonskiene, A., Aukstakalniene, R., Teberaite, Z., Salciute, E., Tikuisis, R., Miliauskas, P., Jurate, S., Kontrimaviciute, E., Tomkute, G., Xuereb, J., Bezzina, M., Borg, F. Joseph, Hemmes, S., Schultz, M., Hollmann, M., Wiersma, I., Binnekade, J., Bos, L., Boer, C., Duvekot, A., Veld, B.I ‘t, Werger, A., Dennesen, P., Severijns, C., Jong, J.D., Hering, J., Beek, R.V., Ivars, S., Jammer, I.B., Breidablik, A., Hodt, K.S., Fjellanger, F., Avalos, M.V., Jannicke, M.O., Andersson, E., Amir, S.K., Molina, R., Wutai, S., Morais, E., Tareco, G., Ferreira, D., Amaral, J., Castro, M.D.L.G., Cadilha, S., Appleton, S., Parente, S., Correia, M., Martins, D., Monteirosa, A., Ricardo, A., Rodrigues, S., Horhota, L., Grintescu, I.M., Mirea, L., Grintescu, I.C., Corneci, D., Negoita, S., Dutu, M., Popescu Garotescu, I., Filipescu, D., Prodan, A.B., Droc, G., Fota, R., Popescu, M., Tomescu, D., Petcu, A.M., Tudoroiu, M.I., Moise, A., Guran, C.T., Gherghina, I., Costea, D., Cindea, I., Copotoiu, S.M., Copotoiu, R., Barsan, V., Tolcser, Z., Riciu, M., Moldovan, S.G., Veres, M., Gritsan, A., Kapkan, T., Gritsan, G., Korolkov, O., Kulikov, A., Lubnin, A., Ovezov, A., Prokoshev, P., Lugovoy, A., Anipchenko, N., Babayants, A., Komissarova, I., Zalina, K., Likhvantsev, V., Fedorov, S., Lazukic, A., Pejakovic, J., Mihajlovic, D., Kusnierikova, Z., Zelinkova, M., Bruncakova, K., Polakovicova, L., Sobona, V., Barbka, N.S., Ana, P.G., Jovanov, M., Strazisar, B., Jasmina, M.B., Vesna, N.J., Voje, M., Grynyuk, A., Kostadinov, I., Alenka, S.V., Moral, V., Unzueta, M.C., Puigbo, C., Fava, J., Canet, J., Moret, E., Nunez, M.R., Sendra, M., Brunelli, A., Rodenas, F., Monedero, P., Hidalgo, F., Yepes, M.J., Martinez-Simon, A., Abajo, A., Lisi, A., Perez, G., Martinez, R., Granell, M., Vivo, J.T., Ruiz, C.S., Andrés Ibañez, J.A.D., Pastor, E., Soro, M., Ferrando, C., Defez, M., Cesar Aldecoa, A.S., Perez, R., Rico, J., Jawad, M., Saeed, Y., Gillberg, L., Bengisun, Z.K., Kazbek, B.K., Coskunfirat, N., Boztug, N., Sanli, S., Yilmaz, M., Hadimioglu, N., Senturk, N.M., Camci, E., Kucukgoncu, S., Sungur, Z., Sivrikoz, N., Ozgen, S.U., Toraman, F., Selvi, O., Senturk, O., Yildiz, M., Kuvaki, B., Gunenc, F., Kucukguclu, S., Ozbilgin, S., Maral, J., Canli, S., Arun, O., Saltali, A., Aydogan, E., Akgun, F.N., Sanlikarip, C., Karaman, F.M., Mazur, A., Vorotyntsev, S., Rousseau, G., Barrett, C., Stancombe, L., Shelley, B., Scholes, H., Limb, J., Rafi, A., Wayman, L., Deane, J., Rogerson, D., Williams, J., Yates, S., Rogers, E., Pulletz, M., Moreton, S., Jones, S., Venkatesh, S., Burton, M., Brown, L., Goodall, C., Rucklidge, M., Fuller, D., Nadolski, M., Kusre, S., Lundberg, M., Everett, L., Nutt, H., Zuleika, M., Carvalho, P., Clements, D., Ben, C.B., Watt, P., Raymode, P., Pearse, R., Mohr, O., Raj, A., Creary, T., Chishti, A., Bell, A., Higham, C., Cain, A., Gibb, S., Mowat, S., Franklin, D., West, C., Minto, G., Boyd, N., Mills, G., Calton, E., Walker, R., Mackenzie, F., Ellison, B., Roberts, H., Chikungwa, M., Jackson, C., Donovan, A., Foot, J., Homan, E., Montgomery, J., Portch, D., Mercer, P., Palmer, J., Paddle, J., Fouracres, A., Datson, A., Andrew, A., Welch, L., Rose, A., Varma, S., Simeson, K., Rambhatla, M., Susarla, J., Marri, S., Kodaganallur, K., Das, A., Algarsamy, S., Colley, J., Davies, S., Szewczyk, M., Smith, T., Ana, F.B., Luzier, E., Almagro, A., Melo, M.V., Fernando, L., Sulemanji, D., Sprung, J., Weingarten, T., Kor, D., Scavonetto, F., Tze, Y., Gregoretti, C., Neto, A.S., Hemmes, S.N.T., Ball, L., Hollmann, M.W., Mills, G.H., Melo, M.F.V., Putensen, C., Gama de Abreu, M., and Schultz, M.J.

Published
2019
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30. A 490 GHz planar circuit balanced Nb-Al$_\mathbf{2}$O$_{\mathbf{3}}$-Nb quasiparticle mixer for radio astronomy: Application to quantitative local oscillator noise determination

Author

Westig, M. P., Justen, M., Jacobs, K., Stutzki, J., Schultz, M., Schomacker, F., and Honingh, C. E.

Subjects
Physics - Instrumentation and Detectors
Abstract

This article presents a heterodyne experiment which uses a 380-520 GHz planar circuit balanced Nb-$\mathrm{Al_2O_3}$-Nb superconductor-insulator-superconductor (SIS) quasiparticle mixer with 4-8 GHz instantaneous intermediate frequency (IF) bandwidth to quantitatively determine local oscillator (LO) noise. A balanced mixer is a unique tool to separate noise at the mixer's LO port from other noise sources. This is not possible in single-ended mixers. The antisymmetric IV characteristic of a SIS mixer further helps to simplify the measurements. The double-sideband receiver sensitivity of the balanced mixer is 2-4 times the quantum noise limit $h\nu/k_B$ over the measured frequencies with a maximum LO noise rejection of 15 dB. This work presents independent measurements with three different LO sources that produce the reference frequency but also an amount of near-carrier noise power which is quantified in the experiment as a function of the LO and IF frequency in terms of an equivalent noise temperature $T_{LO}$. In a second experiment we use only one of two SIS mixers of the balanced mixer chip, in order to verify the influence of near-carrier LO noise power on a single-ended heterodyne mixer measurement. We find an IF frequency dependence of near-carrier LO noise power. The frequency-resolved IF noise temperature slope is flat or slightly negative for the single-ended mixer. This is in contrast to the IF slope of the balanced mixer itself which is positive due to the expected IF roll-off of the mixer. This indicates a higher noise level closer to the LO's carrier frequency. Our findings imply that near-carrier LO noise has the largest impact on the sensitivity of a receiver system which uses mixers with a low IF band, for example superconducting hot-electron bolometer (HEB) mixers., Comment: 13 pages, 8 figures, 2 tables, see manuscript for complete abstract

Published
2012
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31. Terahertz hot electron bolometer waveguide mixers for GREAT

Author

Pütz, P., Honingh, C. E., Jacobs, K., Justen, M., Schultz, M., and Stutzki, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Supplementing the publications based on the first-light observations with the German Receiver for Astronomy at Terahertz frequencies (GREAT) on SOFIA, we present background information on the underlying heterodyne detector technology. We describe the superconducting hot electron bolometer (HEB) detectors that are used as frequency mixers in the L1 (1400 GHz), L2 (1900 GHz), and M (2500 GHz) channels of GREAT. Measured performance of the detectors is presented and background information on their operation in GREAT is given. Our mixer units are waveguide-based and couple to free-space radiation via a feedhorn antenna. The HEB mixers are designed, fabricated, characterized, and flight-qualified in-house. We are able to use the full intermediate frequency bandwidth of the mixers using silicon-germanium multi-octave cryogenic low-noise amplifiers with very low input return loss. Superconducting HEB mixers have proven to be practical and sensitive detectors for high-resolution THz frequency spectroscopy on SOFIA. We show that our niobium-titanium-nitride (NbTiN) material HEBs on silicon nitride (SiN) membrane substrates have an intermediate frequency (IF) noise roll-off frequency above 2.8 GHz, which does not limit the current receiver IF bandwidth. Our mixer technology development efforts culminate in the first successful operation of a waveguide-based HEB mixer at 2.5 THz and deployment for radioastronomy. A significant contribution to the success of GREAT is made by technological development, thorough characterization and performance optimization of the mixer and its IF interface for receiver operation on SOFIA. In particular, the development of an optimized mixer IF interface contributes to the low passband ripple and excellent stability, which GREAT demonstrated during its initial successful astronomical observation runs., Comment: Accepted for publication in A&A (SOFIA/GREAT special issue)

Published
2012
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32. Field-dependent anisotropic magnetoresistance and planar Hall effect in epitaxial magnetite thin films

Author

Naftalis, N., Kaplan, A., Schultz, M., Vaz, C. A. F., Moyer, J. A., Ahn, C. H., and Klein, L.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

A systematic study of the temperature and magnetic field dependence of the longitudinal and transverse resistivities of epitaxial thin films of magnetite (Fe3O4) is reported. The anisotropic magnetoresistance (AMR) and the planar Hall effect (PHE) are sensitive to the in-plane orientation of current and magnetization with respect to crystal axes in a way consistent with the cubic symmetry of the system. We also show that the AMR exhibit sign reversal as a function of temperature, and that it shows significant field dependence without saturation up to 9 T. Our results provide a unified description of the anisotropic magnetoresistance effects in epitaxial magnetite films and illustrate the need for a full determination of the resistivity tensor in crystalline systems.

Published
2011
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33. Suppression of the large-scale Lorentz force by turbulence

Author

Ruediger, G., Kitchatinov, L. L., and Schultz, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Physics - Fluid Dynamics
Abstract

The components of the total stress tensor (Reynolds stress plus Maxwell stress) are computed within the quasilinear approximation for a driven turbulence influenced by a large-scale magnetic background field. The conducting fluid has an arbitrary magnetic Prandtl number and the turbulence without the background field is assumed as homogeneous and isotropic with a free Strouhal number St. The total large-scale magnetic tension is always reduced by the turbulence with the possibility of a `catastrophic quenching' for large magnetic Reynolds number Rm so that even its sign is reversed. The total magnetic pressure is enhanced by turbulence with short correlation time (`white noise') but it is reduced by turbulence with long correlation time. Also in this case the sign of the total pressure may reverse but only for special turbulences with sufficiently large St> 1. The turbulence-induced terms of the stress tensor are suppressed by strong magnetic fields. For the tension term this quenching grows with the square of the Hartmann number of the magnetic field. For microscopic (i.e. small) diffusivity values the magnetic tension term becomes thus highly quenched even for field amplitudes much smaller than their equipartition value. In the opposite case of large-eddy simulations the magnetic quenching is only mild but then also the turbulence-induced Maxwell tensor components for weak fields remain rather small., Comment: 7 pages, 5 figures, submitted to Astron. Nachr

Published
2011
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34. The angular momentum transport by standard MRI in quasi-Kepler cylindric Taylor-Couette flows

Author

Gellert, M., Rüdiger, G., and Schultz, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The instability of a quasi-Kepler flow in dissipative Taylor-Couette systems under the presence of an homogeneous axial magnetic field is considered with focus to the excitation of nonaxisymmetric modes and the resulting angular momentum transport. The excitation of nonaxisymmetric modes requires higher rotation rates than the excitation of the axisymmetric mode and this the more the higher the azimuthal mode number m. We find that the weak-field branch in the instability map of the nonaxisymmetric modes has always a positive slope (in opposition to the axisymmetric modes) so that for given magnetic field the modes with m>0 always have an upper limit of the supercritical Reynolds number. In order to excite a nonaxisymmetric mode at 1 AU in a Kepler disk a minimum field strength of about 1 Gauss is necessary. For weaker magnetic field the nonaxisymmetric modes decay. The angular momentum transport of the nonaxisymmetric modes is always positive and depends linearly on the Lundquist number of the background field. The molecular viscosity and the basic rotation rate do not influence the related {\alpha}-parameter. We did not find any indication that the MRI decays for small magnetic Prandtl number as found by use of shearing-box codes. At 1 AU in a Kepler disk and a field strength of about 1 Gauss the {\alpha} proves to be (only) of order 0.005.

Published
2011
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35. Screening in graphene antidot lattices

Author

Schultz, M. H., Jauho, A. P., and Pedersen, T. G.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We compute the dynamical polarization function for a graphene antidot lattice in the random-phase approximation. The computed polarization functions display a much more complicated structure than what is found for pristine graphene (even when evaluated beyond the Dirac-cone approximation); this reflects the miniband structure and the associated van Hove singularities of the antidot lattice. The polarization functions depend on the azimuthal angle of the {\bf q}-vector. We develop approximations to ease the numerical work, and critically evaluate the performance of the various schemes. We also compute the plasmon dispersion law, and find an approximate square-root dependence with a suppressed plasmon frequency as compared to doped graphene. The plasmon dispersion is nearly isotropic, and the developed approximation schemes agree well with the full calculation.

Published
2011
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36. Balanced superconductor-insulator-superconductor mixer on a 9~$\mu$m silicon membrane

Author

Westig, M. P., Jacobs, K., Stutzki, J., Schultz, M., Justen, M., and Honingh, C. E.

Subjects
Physics - Instrumentation and Detectors, Condensed Matter - Superconductivity
Abstract

We present a 380-520 GHz balanced superconductor-insulator-superconductor (SIS) mixer on a single silicon substrate. All radio-frequency (RF) circuit components are fabricated on a $9 \mu$m thick membrane. The intermediate frequency (IF) is separately amplified and combined. The balanced mixer chip, using Nb/Al/Al$_{2}$O$_{3}$/Nb SIS junctions, is mounted in a tellurium copper waveguide block at 4.2 K using Au beam lead contacts. We find uncorrected minimum receiver double-sideband noise temperatures of 70 K and a noise suppression of up to 18 dB, measured within a 440-495 GHz RF and a 4-8 GHz IF bandwidth, representing state-of-the-art device performance., Comment: 10 pages, 4 figures, Accepted by Superconductor Science & Technology

Published
2011
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37. The Tayler instability of toroidal magnetic fields in a columnar gallium experiment

Author

Ruediger, G., Schultz, M., and Gellert, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The nonaxisymmetric Tayler instability of toroidal magnetic fields due to axial electric currents is studied for conducting incompressible fluids between two coaxial cylinders without endplates. The inner cylinder is considered as so thin that even the limit of R_in \to 0 can be computed. The magnetic Prandtl number is varied over many orders of magnitudes but the azimuthal mode number of the perturbations is fixed to m=1. In the linear approximation the critical magnetic field amplitudes and the growth rates of the instability are determined for both resting and rotating cylinders. Without rotation the critical Hartmann numbers do {\em not} depend on the magnetic Prandtl number but this is not true for the growth rates. For given product of viscosity and magnetic diffusivity the growth rates for small and large magnetic Prandtl number are much smaller than those for Pm=1. For gallium under the influence of a magnetic field at the outer cylinder of 1 kG the resulting growth time is 5 s. The minimum electric current through a container of 10 cm diameter to excite the kink-type instability is 3.20 kA. For a rotating container both the critical magnetic field and the related growth times are larger than for the resting column., Comment: 7 pages, 9 figures, submitted to Astron. Nachr

Published
2010
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38. The pinch-type instability of helical magnetic fields

Author

Ruediger, G., Schultz, M., and Elstner, D.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

To find out whether toroidal field can stably exist in galaxies the current-driven instability of toroidal magnetic fields is considered under the influence of an axial magnetic field component and under the influence of both rigid and differential rotation. The MHD equations are solved in a simplified model with cylindric geometry. We assume the axial field as uniform and the fluid as incompressible. The stability of a toroidal magnetic field is strongly influenced by uniform axial magnetic fields. If both field components are of the same order of magnitude then the instability is slightly supported and modes with m>1 dominate. If the axial field even dominates the most unstable modes have again m>1 but the field is strongly stabilized. All modes are suppressed by a fast rigid rotation where the m=1 mode maximally resists. Just this mode becomes best re-animated for \Omega > \Omega^A (\Omega^A the Alfven frequency) if the rotation has a negative shear. -- Strong indication has been found for a stabilization of the nonaxisymmetric modes for fluids with small magnetic Prandtl number if they are unstable for Pm=1. For rotating fluids the higher modes with m>1 do not play an important role in the linear theory. In the light of our results galactic fields should be marginally unstable against perturbations with m<= 1. The corresponding growth rates are of the order of the rotation period of the inner part of the galaxy., Comment: 7 pages, 9 figures, submitted to Astron. Astrophys

Published
2010
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39. HIFI spectroscopy of low-level water transitions in M82

Author

Weiss, A., Requena-Torres, M. A., Guesten, R., Garcia-Burillo, S., Harris, A. I., Israel, F. P., Klein, T., Kramer, C., Lord, S., Martin-Pintado, J., Roellig, M., Stutzki, J., Szczerba, R., van der Werf, P. P., Philipp-May, S., Yorke, H., Akyilmaz, M., Gal, C., Higgins, R., Marston, A., Roberts, J., Schloeder, F., Schultz, M., Teyssier, D., Whyborn, N., and Wunsch, H. J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present observations of the rotational ortho-water ground transition, the two lowest para-water transitions, and the ground transition of ionised ortho-water in the archetypal starburst galaxy M82, performed with the HIFI instrument on the Herschel Space Observatory. These observations are the first detections of the para-H2O(111-000) (1113\,GHz) and ortho-H2O+(111-000) (1115\,GHz) lines in an extragalactic source. All three water lines show different spectral line profiles, underlining the need for high spectral resolution in interpreting line formation processes. Using the line shape of the para-H2O(111-000) and ortho-H2O+(111-000) absorption profile in conjunction with high spatial resolution CO observations, we show that the (ionised) water absorption arises from a ~2000 pc^2 region within the HIFI beam located about ~50 pc east of the dynamical centre of the galaxy. This region does not coincide with any of the known line emission peaks that have been identified in other molecular tracers, with the exception of HCO. Our data suggest that water and ionised water within this region have high (up to 75%) area-covering factors of the underlying continuum. This indicates that water is not associated with small, dense cores within the ISM of M82 but arises from a more widespread diffuse gas component., Comment: 5 pages, 4 figures. Accepted for publication in A&A

Published
2010
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40. Dissipative Taylor-Couette flows under the influence of helical magnetic fields

Author

Ruediger, G., Gellert, M., Schultz, M., and Hollerbach, R.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The linear stability of MHD Taylor-Couette flows in axially unbounded cylinders is considered, for magnetic Prandtl number unity. Magnetic fields varying from purely axial to purely azimuthal are imposed, with a general helical field parameterized by \beta=B_\phi/B_z. We map out the transition from the standard MRI for \beta=0 to the nonaxisymmetric Azimuthal MagnetoRotational Instability (AMRI) for \beta\to \infty. For finite \beta, positive and negative wave numbers m, corresponding to right and left spirals, are no longer identical. The transition from \beta=0 to \beta\to\infty includes all the possible forms of MRI with axisymmetric and nonaxisymmetric modes. For the nonaxisymmetric modes, the most unstable mode spirals in the opposite direction to the background field. The standard (\beta=0) MRI is axisymmetric for weak fields (including the instability with the lowest Reynolds number) but is nonaxisymmetric for stronger fields. If the azimuthal field is due in part to an axial current flowing through the fluid itself (and not just along the central axis), then it is also unstable to the nonaxisymmetric Tayler instability, which is most effective without rotation. For large \beta this instability has wavenumber m=1, whereas for \beta\simeq 1 m=2 is most unstable. The most unstable mode spirals in the same direction as the background field., Comment: 9 pages, 11 figures

Published
2010
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41. Eddy viscosity and turbulent Schmidt number by kink-type instability of strong toroidal magnetic fields

Author

Ruediger, G., Gellert, M., and Schultz, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The potential of the nonaxisymmetric magnetic instability to transport angular momentum and to mix chemicals is probed considering the stability of a nearly uniform toroidal field between conducting cylinders with different rotation rates. The fluid between the cylinders is assumed as incompressible and to be of uniform density. With a linear theory the neutral-stability maps for m=1 are computed. Rigid rotation must be subAlfvenic to allow instability while for differential rotation with negative shear also an unstable domain with superAlfvenic rotation exists. The rotational quenching of the magnetic instability is strongest for magnetic Prandtl number Pm=1 and becomes much weaker for Pm unequal 1. The effective angular momentum transport by the instability is directed outwards(inwards) for subrotation(superrotation). The resulting magnetic-induced eddy viscosities exceed the microscopic values by factors of 10-100. This is only true for superAlfvenic flows; in the strong-field limit the values remain much smaller. The same instability also quenches concentration gradients of chemicals by its nonmagnetic fluctuations. The corresponding diffusion coefficient remains always smaller than the magnetic-generated eddy viscosity. A Schmidt number of order 30 is found as the ratio of the effective viscosity and the diffusion coefficient. The magnetic instability transports much more angular momentum than that it mixes chemicals., Comment: 9 pages, 12 figures, submitted

Published
2009
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42. Tayler instability of toroidal magnetic fields in MHD Taylor-Couette flows

Author

Ruediger, G. and Schultz, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The nonaxisymmetric 'kink-type' Tayler instability (TI) of toroidal magnetic fields is studied for conducting incompressible fluids of uniform density between two infinitely long cylinders rotating around the same axis. It is shown that for resting cylinders the critical Hartmann number for the unstable modes does not depend on Pm. By rigid rotation the instability is suppressed where the critical ratio of the rotation velocity and the Alfven velocity of the field (only) slightly depends on the magnetic Prandtl number Pm. For Pm=1 the rotational quenching of TI takes its maximum. Rotation laws with negative shear (i.e. d\Omega/dR<0) strongly destabilize the toroidal field if the rotation is not too fast. For sufficiently high Reynolds numbers of rotation the suppression of the nonaxisymmetric magnetic instability always dominates. The angular momentum transport of the instability is anticorrelated with the shear so that an eddy viscosity can be defined which proves to be positive. For negative shear the Maxwell stress of the perturbations remarkably contributes to the angular momentum transport. We have also shown the possibility of laboratory TI experiments with a wide-gap container filled with fluid metals like sodium or gallium. Even the effect of the rotational stabilization can be reproduced in the laboratory with electric currents of only a few kAmp., Comment: 9 pages, 11 figures, subm

Published
2009
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45. Destabilisation of hydrodynamically stable rotation laws by azimuthal magnetic fields

Author

Ruediger, G., Hollerbach, R., Schultz, M., and Elstner, D.

Subjects
Astrophysics
Abstract

We consider the effect of toroidal magnetic fields on hydrodynamically stable Taylor-Couette differential rotation flows. For current-free magnetic fields a nonaxisymmetric m=1 magnetorotational instability arises when the magnetic Reynolds number exceeds O (100). We then consider how this `azimuthal magnetorotational instability' (AMRI) is modified if the magnetic field is not current-free, but also has an associated electric current throughout the fluid. This gives rise to current-driven Tayler instabilities (TI) that exist even without any differential rotation at all. The interaction of the AMRI and the TI is then considered when both electric currents and differential rotation are present simultaneously. The magnetic Prandtl number Pm turns out to be crucial in this case. Large Pm have a destabilizing influence, and lead to a smooth transition between the AMRI and the TI. In contrast, small Pm have a stabilizing influence, with a broad stable zone separating the AMRI and the TI. In this region the differential rotation is acting to stabilize the Tayler instabilities, with possible astrophysical applications (Ap stars). The growth rates of both the AMRI and the TI are largely independent of Pm, with the TI acting on the timescale of a single rotation period, and the AMRI slightly slower, but still on the basic rotational timescale. The azimuthal drift timescale is ~20 rotations, and may thus be a (flip-flop) timescale of stellar activity between the rotation period and the diffusion time., Comment: 7 pages, 8 figures, submitted to MNRAS

Published
2007
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46. A non-axisymmetric magnetorotational instability of a purely toroidal magnetic field

Author

Hollerbach, R., Rudiger, G., Schultz, M., and Elstner, D.

Subjects
Astrophysics
Abstract

We consider the flow of an electrically conducting fluid between differentially rotating cylinders, in the presence of an externally imposed toroidal field B_0 (r_i/r) e_phi. It is known that the classical, axisymmetric magnetorotational instability does not exist for such a purely toroidal imposed field. We show here that a non-axisymmetric magnetorotational instability does exist, having properties very similar to the axisymmetric magnetorotational instability in the presence of an axial field.

Published
2006

47. Theory of current instability experiments in magnetic Taylor-Couette flows

Author

Ruediger, G., Schultz, M., Shalybkov, D., and Hollerbach, R.

Subjects
Astrophysics
Abstract

We consider the linear stability of dissipative MHD Taylor-Couette flow with imposed toroidal magnetic fields. The inner and outer cylinders can be either insulating or conducting; the inner one rotates, the outer one is stationary. The magnetic Prandtl number can be as small as 10-5, approaching realistic liquid-metal values. The magnetic field destabilizes the flow, except for radial profiles of B$_\phi$(R) close to the current-free solution. The profile with B$_{in}$=B$_{out}$ (the most uniform field) is considered in detail. For weak fields the TC-flow is stabilized, until for moderately strong fields the m=1 azimuthal mode dramatically destabilizes the flow again. There is thus a maximum value for the critical Reynolds number. For sufficiently strong fields (as measured by the Hartmann number) the toroidal field is always unstable, even for Re=0. The electric currents needed to generate the required toroidal fields in laboratory experiments are a few kA if liquid sodium is used, somewhat more if gallium is used. Weaker currents are needed for wider gaps, so a wide-gap apparatus could succeed even with gallium. The critical Reynolds numbers are only somewhat larger than the nonmagnetic values, so such an experiment would require only modest rotation rates., Comment: 8 pages, 4 figures, submitted to Phys. Rev. E

Published
2006
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48. The stability of MHD Taylor-Couette flow with current-free spiral magnetic fields between conducting cylinders

Author

Ruediger, G., Hollerbach, R., Schultz, M., and Shalybkov, D. A.

Subjects
Astrophysics
Abstract

We study the magnetorotational instability in cylindrical Taylor-Couette flow, with the (vertically unbounded) cylinders taken to be perfect conductors, and with externally imposed spiral magnetic fields. The azimuthal component of this field is generated by an axial current inside the inner cylinder, and may be slightly stronger than the axial field. We obtain an instability beyond the Rayleigh line, for Reynolds numbers of order 1000 and Hartmann numbers of order 10, and independent of the (small) magnetic Prandtl number. For experiments with R_out = 2 R_in = 10 cm and Omega_out = 0.27 Omega_in, the instability appears for liquid sodium for axial fields of ~20 Gauss and axial currents of \~1200 A. For gallium the numbers are ~50 Gauss and ~3200 A. The vertical cell size is about twice the cell size known for nonmagnetic experiments., Comment: 5 pages, 7 figures, submitted to Astronomische Nachrichten

Published
2005
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49. Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes

Author

Gan, T.J., Peyton, P., Tramèr, M., Cyna, A., De Oliveira, G.S., Jr., Wu, C., Jensen, M., Kehlet, H., Botti, M., Boney, O., Haller, G., Grocott, M., Cook, T., Fleisher, L., Neuman, M., Story, D., Gruen, R., Bampoe, S., Evered, Lis, Scott, D., Silbert, B., van Dijk, D., Kalkman, C., Chan, M., Grocott, H., Eckenhoff, R., Rasmussen, L., Eriksson, L., Beattie, S., Wijeysundera, D., Landoni, G., Biccard, B., Howell, S., Nagele, P., Richards, T., Lamy, A., Lalu, M., Pearse, R., Mythen, M., Canet, J., Moller, A., Gin, T., Schultz, M., Pelosi, P., Gabreu, M., Futier, E., Creagh-Brown, B., Abbott, T., Klein, A., Corcoran, T., Jamie Cooper, D., Dieleman, S., Diouf, E., McIlroy, D., Bellomo, R., Shaw, A., Prowle, J., Karkouti, K., Billings, J., Mazer, D., Jayarajah, M., Murphy, M., Bartoszko, J., Sneyd, R., Morris, S., George, R., Moonesinghe, R., Shulman, M., Lane-Fall, M., Nilsson, U., Stevenson, N., van Klei, W., Cabrini, L., Miller, T., Jackson, S., Alkhaffaf, B., Buggy, D.J., Freeman, J., Johnson, M.Z., Leslie, K., Riedel, B., Sessler, D.I., Kurz, A., Gottumukkala, V., Short, T., Pace, N., and Myles, P.S.

Published
2018
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50. Bounding the role of black carbon in the climate system: A scientific assessment

Author

Bond, T. C, Doherty, S. J, Fahey, D. W, Forster, P. M, Berntsen, T., DeAngelo, B. J, Flanner, M. G, Ghan, S., Kärcher, B., Koch, D., Kinne, S., Kondo, Y., Quinn, P. K, Sarofim, M. C, Schultz, M. G, Schulz, M., Venkataraman, C., Zhang, H., Zhang, S., Bellouin, N., Guttikunda, S. K, Hopke, P. K, Jacobson, M. Z, Kaiser, J. W, Klimont, Z., Lohmann, U., Schwarz, J. P, Shindell, D., Storelvmo, T., Warren, S. G, and Zender, C. S

Subjects
black carbon, climate forcing, aerosol
Abstract

Black carbon aerosol plays a unique and important role in Earth's climate system. Black carbon is a type of carbonaceous material with a unique combination of physical properties. This assessment provides an evaluation of black-carbon climate forcing that is comprehensive in its inclusion of all known and relevant processes and that is quantitative in providing best estimates and uncertainties of the main forcing terms: direct solar absorption; influence on liquid, mixed phase, and ice clouds; and deposition on snow and ice. These effects are calculated with climate models, but when possible, they are evaluated with both microphysical measurements and field observations. Predominant sources are combustion related, namely, fossil fuels for transportation, solid fuels for industrial and residential uses, and open burning of biomass. Total global emissions of black carbon using bottom-up inventory methods are 7500 Gg yr(-1) in the year 2000 with an uncertainty range of 2000 to 29000. However, global atmospheric absorption attributable to black carbon is too low in many models and should be increased by a factor of almost 3. After this scaling, the best estimate for the industrial-era (1750 to 2005) direct radiative forcing of atmospheric black carbon is +0.71 W m(-2) with 90% uncertainty bounds of (+0.08, +1.27) W m(-2). Total direct forcing by all black carbon sources, without subtracting the preindustrial background, is estimated as +0.88 (+0.17, +1.48) W m(-2). Direct radiative forcing alone does not capture important rapid adjustment mechanisms. A framework is described and used for quantifying climate forcings, including rapid adjustments. The best estimate of industrial-era climate forcing of black carbon through all forcing mechanisms, including clouds and cryosphere forcing, is +1.1 W m(-2) with 90% uncertainty bounds of +0.17 to +2.1 W m(-2). Thus, there is a very high probability that black carbon emissions, independent of co-emitted species, have a positive forcing and warm the climate. We estimate that black carbon, with a total climate forcing of +1.1 W m(-2), is the second most important human emission in terms of its climate forcing in the present-day atmosphere; only carbon dioxide is estimated to have a greater forcing. Sources that emit black carbon also emit other short-lived species that may either cool or warm climate. Climate forcings from co-emitted species are estimated and used in the framework described herein. When the principal effects of short-lived co-emissions, including cooling agents such as sulfur dioxide, are included in net forcing, energy-related sources (fossil fuel and biofuel) have an industrial-era climate forcing of +0.22 (-0.50 to +1.08) W m(-2) during the first year after emission. For a few of these sources, such as diesel engines and possibly residential biofuels, warming is strong enough that eliminating all short-lived emissions from these sources would reduce net climate forcing (i.e., produce cooling). When open burning emissions, which emit high levels of organic matter, are included in the total, the best estimate of net industrial-era climate forcing by all short-lived species from black-carbon-rich sources becomes slightly negative (-0.06 W m(-2) with 90% uncertainty bounds of -1.45 to +1.29 W m(-2)).The uncertainties in net climate forcing from black-carbon-rich sources are substantial, largely due to lack of knowledge about cloud interactions with both black carbon and co-emitted organic carbon. In prioritizing potential black-carbon mitigation actions, non-science factors, such as technical feasibility, costs, policy design, and implementation feasibility play important roles. The major sources of black carbon are presently in different stages with regard to the feasibility for near-term mitigation. This assessment, by evaluating the large number and complexity of the associated physical and radiative processes in black-carbon climate forcing, sets a baseline from which to improve future climate forcing estimates.

Published
2013

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