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4. A Preliminary Analysis of Thyrotropin Measurement from Finger Stick Dried Blood Spot with an Automated High-Throughput Immunoassay Analyzer

Author

CDL Patiëntenzorg KC, Pathologie Groep Bovenschen, Cancer, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), CDL Unit Externe Business/ ARCADIA, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Front office & ext. business, Schakelaar, Michael Y., Lentjes, Eef G.W.M., Visser, Timothy S.Q., Schoneveld, Arjan H., Hoefer, Imo E., Tiel Groenestege, Wouter M., CDL Patiëntenzorg KC, Pathologie Groep Bovenschen, Cancer, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), CDL Unit Externe Business/ ARCADIA, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Front office & ext. business, Schakelaar, Michael Y., Lentjes, Eef G.W.M., Visser, Timothy S.Q., Schoneveld, Arjan H., Hoefer, Imo E., and Tiel Groenestege, Wouter M.

Published
2023

5. Analysis of C-reactive protein from finger stick dried blood spot to predict high risk of cardiovascular disease

Author

CDL Patiëntenzorg KC, Pathologie Groep Bovenschen, Cancer, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), CDL Unit Externe Business/ ARCADIA, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Front office & ext. business, Schakelaar, Michael Y., Kemperman, Hans, Schoneveld, Arjan H., Hoefer, Imo E., Tiel Groenestege, Wouter M., CDL Patiëntenzorg KC, Pathologie Groep Bovenschen, Cancer, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), CDL Unit Externe Business/ ARCADIA, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Cluster Front office & ext. business, Schakelaar, Michael Y., Kemperman, Hans, Schoneveld, Arjan H., Hoefer, Imo E., and Tiel Groenestege, Wouter M.

Published
2023

6. The influence of apical periodontitis on circulatory inflammatory mediators in peripheral blood: A prospective case–control study

Author

UMC Utrecht Holding, CDL Unit Externe Business/ ARCADIA, CDL Arcadia, Georgiou, Athina Christina, Twisk, Jos W.R., Crielaard, Wim, Ouwerling, Peter, Schoneveld, Arjan H., van der Waal, Suzette Veronica, UMC Utrecht Holding, CDL Unit Externe Business/ ARCADIA, CDL Arcadia, Georgiou, Athina Christina, Twisk, Jos W.R., Crielaard, Wim, Ouwerling, Peter, Schoneveld, Arjan H., and van der Waal, Suzette Veronica

Published
2023

7. Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability

Author

Georgakis, Marios K., primary, van der Laan, Sander W., additional, Asare, Yaw, additional, Mekke, Joost M., additional, Haitjema, Saskia, additional, Schoneveld, Arjan H., additional, de Jager, Saskia C.A., additional, Nurmohamed, Nick S., additional, Kroon, Jeffrey, additional, Stroes, Erik S.G., additional, de Kleijn, Dominique P.V., additional, de Borst, Gert J., additional, Maegdefessel, Lars, additional, Soehnlein, Oliver, additional, Pasterkamp, Gerard, additional, and Dichgans, Martin, additional

Published
2021
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8. High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome

Author

Zorgeenheid Vaatchirurgie Medisch, Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, CDL Arcadia, Researchgr. Hart-brein as., Brain, Circulatory Health, Centraal Diagnostisch Laboratorium, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Silvis, Max J.M., Bennekom, Joelle V., Schoneveld, Arjan H., de Winter, Robbert J., Isgum, Ivana, Lessmann, Nikolas, Velthuis, Birgitta K., Pasterkamp, Gerard, Mosterd, Arend, Timmers, Leo, de Kleijn, Dominique P.V., Zorgeenheid Vaatchirurgie Medisch, Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, CDL Arcadia, Researchgr. Hart-brein as., Brain, Circulatory Health, Centraal Diagnostisch Laboratorium, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Silvis, Max J.M., Bennekom, Joelle V., Schoneveld, Arjan H., de Winter, Robbert J., Isgum, Ivana, Lessmann, Nikolas, Velthuis, Birgitta K., Pasterkamp, Gerard, Mosterd, Arend, Timmers, Leo, and de Kleijn, Dominique P.V.

Published
2021

9. Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19

Author

CDL Staf Research, Circulatory Health, CDL Arcadia, Medische Staf Intensive Care, Infection & Immunity, Arts Assistenten Longziekten, Onderzoeksgroep 6, Janssen, Nico A.F., Grondman, Inge, de Nooijer, Aline H., Boahen, Collins K., Koeken, Valerie A.C.M., Matzaraki, Vasiliki, Kumar, Vinod, He, Xuehui, Kox, Matthijs, Koenen, Hans J.P.M., Smeets, Ruben L., Joosten, Irma, Brüggemann, Roger J.M., Kouijzer, Ilse J.E., van der Hoeven, Hans G., Schouten, Jeroen A., Frenzel, Tim, Reijers, Monique H.E., Hoefsloot, Wouter, Dofferhoff, Anton S.M., van Apeldoorn, Marjan J., Blaauw, Marc J.T., Veerman, Karin, Maas, Coen, Schoneveld, Arjan H., Hoefer, Imo E., Derde, Lennie P.G., van Deuren, Marcel, van der Meer, Jos W.M., van Crevel, Reinout, Giamarellos-Bourboulis, Evangelos J., Joosten, Leo A.B., van den Heuvel, Michel M., Hoogerwerf, Jacobien, de Mast, Quirijn, Pickkers, Peter, Netea, Mihai G., van de Veerdonk, Frank L., CDL Staf Research, Circulatory Health, CDL Arcadia, Medische Staf Intensive Care, Infection & Immunity, Arts Assistenten Longziekten, Onderzoeksgroep 6, Janssen, Nico A.F., Grondman, Inge, de Nooijer, Aline H., Boahen, Collins K., Koeken, Valerie A.C.M., Matzaraki, Vasiliki, Kumar, Vinod, He, Xuehui, Kox, Matthijs, Koenen, Hans J.P.M., Smeets, Ruben L., Joosten, Irma, Brüggemann, Roger J.M., Kouijzer, Ilse J.E., van der Hoeven, Hans G., Schouten, Jeroen A., Frenzel, Tim, Reijers, Monique H.E., Hoefsloot, Wouter, Dofferhoff, Anton S.M., van Apeldoorn, Marjan J., Blaauw, Marc J.T., Veerman, Karin, Maas, Coen, Schoneveld, Arjan H., Hoefer, Imo E., Derde, Lennie P.G., van Deuren, Marcel, van der Meer, Jos W.M., van Crevel, Reinout, Giamarellos-Bourboulis, Evangelos J., Joosten, Leo A.B., van den Heuvel, Michel M., Hoogerwerf, Jacobien, de Mast, Quirijn, Pickkers, Peter, Netea, Mihai G., and van de Veerdonk, Frank L.

Published
2021

10. Monocyte-chemoattractant protein-1 levels in human atherosclerotic lesions associate with plaque vulnerability

Author

CDL Onderzoek Pasterkamp, Circulatory Health, Zorgeenheid Vaatchirurgie Medisch, Divisie Heelkundige Specialismen, CDL Arcadia, Experimentele Afd. Cardiologie 2, Infection & Immunity, Brain, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Georgakis, Marios K., van der Laan, Sander W., Asare, Yaw, Mekke, Joost M., Haitjema, Saskia, Schoneveld, Arjan H., de Jager, Saskia C.A., Nurmohamed, Nick S., Kroon, Jeffrey, Stroes, Erik S.G., de Kleijn, Dominique P.V., de Borst, Gert J., Maegdefessel, Lars, Soehnlein, Oliver, Pasterkamp, Gerard, Dichgans, Martin, CDL Onderzoek Pasterkamp, Circulatory Health, Zorgeenheid Vaatchirurgie Medisch, Divisie Heelkundige Specialismen, CDL Arcadia, Experimentele Afd. Cardiologie 2, Infection & Immunity, Brain, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Georgakis, Marios K., van der Laan, Sander W., Asare, Yaw, Mekke, Joost M., Haitjema, Saskia, Schoneveld, Arjan H., de Jager, Saskia C.A., Nurmohamed, Nick S., Kroon, Jeffrey, Stroes, Erik S.G., de Kleijn, Dominique P.V., de Borst, Gert J., Maegdefessel, Lars, Soehnlein, Oliver, Pasterkamp, Gerard, and Dichgans, Martin

Published
2021

11. Extracellular vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain

Author

Zorgeenheid Vaatchirurgie Medisch, Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, CDL Arcadia, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Van Bennekom, Joelle, Silvis, Max J.M., Timmerman, Nathalie, Schoneveld, Arjan H., Grobbee, Diederick E., De Winter, Robbert J., Mosterd, Arend, Timmers, Leo, De Kleijn, Dominique P.V., Zorgeenheid Vaatchirurgie Medisch, Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, CDL Arcadia, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Van Bennekom, Joelle, Silvis, Max J.M., Timmerman, Nathalie, Schoneveld, Arjan H., Grobbee, Diederick E., De Winter, Robbert J., Mosterd, Arend, Timmers, Leo, and De Kleijn, Dominique P.V.

Published
2020

14. Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain

Author

Dekker, Mirthe, primary, Waissi, Farahnaz, additional, van Bennekom, Joelle, additional, Silvis, Max J. M., additional, Timmerman, Nathalie, additional, Schoneveld, Arjan H., additional, Grobbee, Diederick E., additional, de Winter, Robbert J., additional, Mosterd, Arend, additional, Timmers, Leo, additional, and de Kleijn, Dominique P. V., additional

Published
2020
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15. Matrix Metalloproteinase 2 Is Associated With Stable and Matrix Metalloproteinases 8 and 9 With Vulnerable Carotid Atherosclerotic Lesions: A Study in Human Endarterectomy Specimen Pointing to a Role for Different Extracellular Matrix Metalloproteinase Inducer Glycosylation Forms

Author

Sluijter, Joost P.G., Pulskens, Wilco P.C., Schoneveld, Arjan H., Velema, Evelyn, Strijder, Chaylendra F., Frans, Moll, de Vries, Jean-Paul, Verheijen, Jan, Hanemaaijer, Roeland, de Kleijn, Dominique P.V., and Pasterkamp, Gerard

Published
2006
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16. Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure

Author

van den Hoogen, Patricia, de Jager, Saskia C.A., Huibers, Manon M.H., Schoneveld, Arjan H., Puspitasari, Yustina M., Valstar, Gideon B., Oerlemans, Marish I.F.J., de Weger, Roel A., Doevendans, Pieter A., den Ruijter, Hester M., Laman, Jon D., Vink, Aryan, Sluijter, Joost P.G., van den Hoogen, Patricia, de Jager, Saskia C.A., Huibers, Manon M.H., Schoneveld, Arjan H., Puspitasari, Yustina M., Valstar, Gideon B., Oerlemans, Marish I.F.J., de Weger, Roel A., Doevendans, Pieter A., den Ruijter, Hester M., Laman, Jon D., Vink, Aryan, and Sluijter, Joost P.G.

Published
2019

17. Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure

Author

Experimentele Afd. Cardiologie 2, Pathologie MP, Genetica, Genetica Sectie Genoomdiagnostiek, CDL Arcadia, Circulatory Health, Experimentele Afd. Cardiologie 1, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Pathologie Moleculair, Regenerative Medicine and Stem Cells, Pathologie Pathologen staf, Onderzoek Cardiovasculair Reg. Med., van den Hoogen, Patricia, de Jager, Saskia C.A., Huibers, Manon M.H., Schoneveld, Arjan H., Puspitasari, Yustina M., Valstar, Gideon B., Oerlemans, Marish I.F.J., de Weger, Roel A., Doevendans, Pieter A., den Ruijter, Hester M., Laman, Jon D., Vink, Aryan, Sluijter, Joost P.G., Experimentele Afd. Cardiologie 2, Pathologie MP, Genetica, Genetica Sectie Genoomdiagnostiek, CDL Arcadia, Circulatory Health, Experimentele Afd. Cardiologie 1, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Pathologie Moleculair, Regenerative Medicine and Stem Cells, Pathologie Pathologen staf, Onderzoek Cardiovasculair Reg. Med., van den Hoogen, Patricia, de Jager, Saskia C.A., Huibers, Manon M.H., Schoneveld, Arjan H., Puspitasari, Yustina M., Valstar, Gideon B., Oerlemans, Marish I.F.J., de Weger, Roel A., Doevendans, Pieter A., den Ruijter, Hester M., Laman, Jon D., Vink, Aryan, and Sluijter, Joost P.G.

Published
2019

20. Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre‐ and end‐stage heart failure

Author

Hoogen, Patricia, primary, Jager, Saskia C. A., additional, Huibers, Manon M. H., additional, Schoneveld, Arjan H., additional, Puspitasari, Yustina M., additional, Valstar, Gideon B., additional, Oerlemans, Marish I. F. J., additional, Weger, Roel A., additional, Doevendans, Pieter A., additional, Ruijter, Hester M., additional, Laman, Jon D., additional, Vink, Aryan, additional, and Sluijter, Joost P. G., additional

Published
2019
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21. Lowering low-density lipoprotein particles in plasma using dextran sulphate co-precipitates procoagulant extracellular vesicles

Author

Wang, Jiong Wei, Zhang, Ya Nan, Sze, Siu Kwan, van de Weg, Sander M., Vernooij, Flora, Schoneveld, Arjan H., Tan, Sock Hwee, Versteeg, Henri H., Timmers, Leo, Lam, Carolyn S.P., de Kleijn, Dominique P.V., Wang, Jiong Wei, Zhang, Ya Nan, Sze, Siu Kwan, van de Weg, Sander M., Vernooij, Flora, Schoneveld, Arjan H., Tan, Sock Hwee, Versteeg, Henri H., Timmers, Leo, Lam, Carolyn S.P., and de Kleijn, Dominique P.V.

Published
2018

22. Lowering low-density lipoprotein particles in plasma using dextran sulphate co-precipitates procoagulant extracellular vesicles

Author

Cardiologie, Circulatory Health, Analisten, Onderzoek Vrouw Hart & Vaatziekten, Verpleegafd Vaatchirurgie D4 Oost, Infection & Immunity, Wang, Jiong Wei, Zhang, Ya Nan, Sze, Siu Kwan, van de Weg, Sander M., Vernooij, Flora, Schoneveld, Arjan H., Tan, Sock Hwee, Versteeg, Henri H., Timmers, Leo, Lam, Carolyn S.P., de Kleijn, Dominique P.V., Cardiologie, Circulatory Health, Analisten, Onderzoek Vrouw Hart & Vaatziekten, Verpleegafd Vaatchirurgie D4 Oost, Infection & Immunity, Wang, Jiong Wei, Zhang, Ya Nan, Sze, Siu Kwan, van de Weg, Sander M., Vernooij, Flora, Schoneveld, Arjan H., Tan, Sock Hwee, Versteeg, Henri H., Timmers, Leo, Lam, Carolyn S.P., and de Kleijn, Dominique P.V.

Published
2018

23. Loss of y Chromosome in Blood Is Associated with Major Cardiovascular Events during Follow-Up in Men after Carotid Endarterectomy

Author

Haitjema, Saskia, Kofink, Daniel, Van Setten, Jessica, Van Der Laan, Sander W., Schoneveld, Arjan H., Eales, James, Tomaszewski, Maciej, De Jager, Saskia C.A., Pasterkamp, Gerard, Asselbergs, Folkert W., Den Ruijter, Hester M., Haitjema, Saskia, Kofink, Daniel, Van Setten, Jessica, Van Der Laan, Sander W., Schoneveld, Arjan H., Eales, James, Tomaszewski, Maciej, De Jager, Saskia C.A., Pasterkamp, Gerard, Asselbergs, Folkert W., and Den Ruijter, Hester M.

Published
2017

24. Loss of y Chromosome in Blood Is Associated with Major Cardiovascular Events during Follow-Up in Men after Carotid Endarterectomy

Author

Experimentele Afd. Cardiologie 1, Circulatory Health, Onderzoek Precision medicine, Onderzoek Vrouw Hart & Vaatziekten, Analisten, Experimentele Afd. Cardiologie 2, CDL Cluster Onderzoek en Onderwijs, Verpleegkundig Onderzoek, Team Medisch, Haitjema, Saskia, Kofink, Daniel, Van Setten, Jessica, Van Der Laan, Sander W., Schoneveld, Arjan H., Eales, James, Tomaszewski, Maciej, De Jager, Saskia C.A., Pasterkamp, Gerard, Asselbergs, Folkert W., Den Ruijter, Hester M., Experimentele Afd. Cardiologie 1, Circulatory Health, Onderzoek Precision medicine, Onderzoek Vrouw Hart & Vaatziekten, Analisten, Experimentele Afd. Cardiologie 2, CDL Cluster Onderzoek en Onderwijs, Verpleegkundig Onderzoek, Team Medisch, Haitjema, Saskia, Kofink, Daniel, Van Setten, Jessica, Van Der Laan, Sander W., Schoneveld, Arjan H., Eales, James, Tomaszewski, Maciej, De Jager, Saskia C.A., Pasterkamp, Gerard, Asselbergs, Folkert W., and Den Ruijter, Hester M.

Published
2017

25. Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure : An Observational Study in a Dyspnoea Cohort

Author

Zhang, Ya-Nan, Vernooij, Flora, Ibrahim, Irwani, Ooi, Shirley, Gijsberts, Crystel M, Schoneveld, Arjan H, Sen, Kuan Win, den Ruijter, Hester M, Timmers, Leo, Richards, Arthur Mark, Jong, Chun Tzen, Mazlan, Ibrahim, Wang, Jiong-Wei, Lam, Carolyn S P, de Kleijn, Dominique P V, Zhang, Ya-Nan, Vernooij, Flora, Ibrahim, Irwani, Ooi, Shirley, Gijsberts, Crystel M, Schoneveld, Arjan H, Sen, Kuan Win, den Ruijter, Hester M, Timmers, Leo, Richards, Arthur Mark, Jong, Chun Tzen, Mazlan, Ibrahim, Wang, Jiong-Wei, Lam, Carolyn S P, and de Kleijn, Dominique P V

Published
2016

26. Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort

Author

Experimentele Afd. Cardiologie 1, Circulatory Health, Onderzoek Vrouw Hart & Vaatziekten, Analisten, Cardiologie, Infection & Immunity, Zhang, Ya-Nan, Vernooij, Flora, Ibrahim, Irwani, Ooi, Shirley, Gijsberts, Crystel M, Schoneveld, Arjan H, Sen, Kuan Win, den Ruijter, Hester M, Timmers, Leo, Richards, Arthur Mark, Jong, Chun Tzen, Mazlan, Ibrahim, Wang, Jiong-Wei, Lam, Carolyn S P, de Kleijn, Dominique P V, Experimentele Afd. Cardiologie 1, Circulatory Health, Onderzoek Vrouw Hart & Vaatziekten, Analisten, Cardiologie, Infection & Immunity, Zhang, Ya-Nan, Vernooij, Flora, Ibrahim, Irwani, Ooi, Shirley, Gijsberts, Crystel M, Schoneveld, Arjan H, Sen, Kuan Win, den Ruijter, Hester M, Timmers, Leo, Richards, Arthur Mark, Jong, Chun Tzen, Mazlan, Ibrahim, Wang, Jiong-Wei, Lam, Carolyn S P, and de Kleijn, Dominique P V

Published
2016

27. Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort

Author

Zhang, Ya-Nan, primary, Vernooij, Flora, additional, Ibrahim, Irwani, additional, Ooi, Shirley, additional, Gijsberts, Crystel M., additional, Schoneveld, Arjan H., additional, Sen, Kuan Win, additional, den Ruijter, Hester M., additional, Timmers, Leo, additional, Richards, Arthur Mark, additional, Jong, Chun Tzen, additional, Mazlan, Ibrahim, additional, Wang, Jiong-Wei, additional, Lam, Carolyn S. P., additional, and de Kleijn, Dominique P. V., additional

Published
2016
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28. Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes : The Athero-Express Genomics Study

Author

Van Der Laan, Sander W., Foroughi Asl, Hassan, van den Borne, Pleunie, van Setten, Jessica, van der Perk, M. E Madeleine, van de Weg, Sander M., Schoneveld, Arjan H., de Kleijn, Dominique P V, Michoel, Tom, Björkegren, Johan L M, den Ruijter, Hester M., Asselbergs, Folkert W., de Bakker, Paul I W, Pasterkamp, Gerard, Van Der Laan, Sander W., Foroughi Asl, Hassan, van den Borne, Pleunie, van Setten, Jessica, van der Perk, M. E Madeleine, van de Weg, Sander M., Schoneveld, Arjan H., de Kleijn, Dominique P V, Michoel, Tom, Björkegren, Johan L M, den Ruijter, Hester M., Asselbergs, Folkert W., de Bakker, Paul I W, and Pasterkamp, Gerard

Published
2015

29. Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study

Author

Experimentele Afd. Cardiologie 1, Cardiologie, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Analisten, JC onderzoeksprogramma Methodologie, Cancer, CDL Cluster Onderzoek en Onderwijs, Van Der Laan, Sander W., Foroughi Asl, Hassan, van den Borne, Pleunie, van Setten, Jessica, van der Perk, M. E Madeleine, van de Weg, Sander M., Schoneveld, Arjan H., de Kleijn, Dominique P V, Michoel, Tom, Björkegren, Johan L M, den Ruijter, Hester M., Asselbergs, Folkert W., de Bakker, Paul I W, Pasterkamp, Gerard, Experimentele Afd. Cardiologie 1, Cardiologie, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, Analisten, JC onderzoeksprogramma Methodologie, Cancer, CDL Cluster Onderzoek en Onderwijs, Van Der Laan, Sander W., Foroughi Asl, Hassan, van den Borne, Pleunie, van Setten, Jessica, van der Perk, M. E Madeleine, van de Weg, Sander M., Schoneveld, Arjan H., de Kleijn, Dominique P V, Michoel, Tom, Björkegren, Johan L M, den Ruijter, Hester M., Asselbergs, Folkert W., de Bakker, Paul I W, and Pasterkamp, Gerard

Published
2015

30. Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles.

Author

Wang, Jiong-Wei, Zhang, Ya-Nan, Sze, Siu Kwan, van de Weg, Sander M., Vernooij, Flora, Schoneveld, Arjan H., Tan, Sock-Hwee, Versteeg, Henri H., Timmers, Leo, Lam, Carolyn S. P., and de Kleijn, Dominique P. V.

Subjects
LOW density lipoproteins, VESICLES (Cytology), BLOOD coagulation, CARDIOVASCULAR diseases, PROTEOMICS, DEXTRAN sulfate
Abstract

Plasma extracellular vesicles (EVs) are lipid membrane vesicles involved in several biological processes including coagulation. Both coagulation and lipid metabolism are strongly associated with cardiovascular events. Lowering very-low- and low-density lipoprotein ((V)LDL) particles via dextran sulphate LDL apheresis also removes coagulation proteins. It remains unknown, however, how coagulation proteins are removed in apheresis. We hypothesize that plasma EVs that contain high levels of coagulation proteins are concomitantly removed with (V)LDL particles by dextran sulphate apheresis. For this, we precipitated (V)LDL particles from human plasma with dextran sulphate and analyzed the abundance of coagulation proteins and EVs in the precipitate. Coagulation pathway proteins, as demonstrated by proteomics and a bead-based immunoassay, were over-represented in the (V)LDL precipitate. In this precipitate, both bilayer EVs and monolayer (V)LDL particles were observed by electron microscopy. Separation of EVs from (V)LDL particles using density gradient centrifugation revealed that almost all coagulation proteins were present in the EVs and not in the (V)LDL particles. These EVs also showed a strong procoagulant activity. Our study suggests that dextran sulphate used in LDL apheresis may remove procoagulant EVs concomitantly with (V)LDL particles, leading to a loss of coagulation proteins from the blood. [ABSTRACT FROM AUTHOR]

Published
2018
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31. Leukotriene B4 Levels in Human Atherosclerotic Plaques and Abdominal Aortic Aneurysms

Author

van den Borne, Pleunie, primary, van der Laan, Sander W., additional, Bovens, Sandra M., additional, Koole, Dave, additional, Kowala, Mark C., additional, Michael, Laura F., additional, Schoneveld, Arjan H., additional, van de Weg, Sander M., additional, Velema, Evelyn, additional, de Vries, Jean-Paul, additional, de Borst, Gert J., additional, Moll, Frans L., additional, de Kleijn, Dominique P. V., additional, Quax, Paul H. A., additional, Hoefer, Imo E., additional, and Pasterkamp, Gerard, additional

Published
2014
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32. Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events

Author

Peeters, Wouter, primary, de Kleijn, Dominique P.V., additional, Vink, Aryan, additional, van de Weg, Sander, additional, Schoneveld, Arjan H., additional, Sze, Siu Kwan, additional, van der Spek, Peter J., additional, de Vries, Jean-Paul P.M., additional, Moll, Frans L., additional, and Pasterkamp, Gerard, additional

Published
2010
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33. Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events

Author

de Kleijn, Dominique P.V., primary, Moll, Frans L., additional, Hellings, Willem E., additional, Ozsarlak-Sozer, Gonen, additional, de Bruin, Peter, additional, Doevendans, Pieter A., additional, Vink, Aryan, additional, Catanzariti, Louise M., additional, Schoneveld, Arjan H., additional, Algra, Ale, additional, Daemen, Mat J., additional, Biessen, E.A., additional, de Jager, W., additional, Zhang, Huoming, additional, de Vries, Jean-Paul, additional, Falk, Erling, additional, Lim, Sai K., additional, van der Spek, Peter J., additional, Sze, Siu Kwan, additional, and Pasterkamp, Gerard, additional

Published
2010
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34. Toll-Like Receptor 4 Is Involved in Outward Arterial Remodeling

Author

Hollestelle, Saskia C.G., primary, de Vries, Margreet R., additional, van Keulen, J. Karlijn, additional, Schoneveld, Arjan H., additional, Vink, Aryan, additional, Strijder, Chaylendra F., additional, van Middelaar, Ben J., additional, Pasterkamp, Gerard, additional, Quax, Paul H.A., additional, and de Kleijn, Dominique P.V., additional

Published
2004
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42. Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure.

Author

van den Hoogen P, de Jager SCA, Huibers MMH, Schoneveld AH, Puspitasari YM, Valstar GB, Oerlemans MIFJ, de Weger RA, Doevendans PA, den Ruijter HM, Laman JD, Vink A, and Sluijter JPG

Subjects
Case-Control Studies, Disease Progression, Female, Humans, Male, Middle Aged, Myocardium immunology, Stroke Volume immunology, Ventricular Dysfunction, Left blood, Ventricular Dysfunction, Left immunology, Heart Failure blood, Heart Failure immunology, Immunoglobulin G blood, Immunoglobulin G immunology, Myocytes, Cardiac immunology
Abstract

The chronic inflammatory response plays an important role in adverse cardiac remodelling and the development of heart failure (HF). There is also evidence that in the pathogenesis of several cardiovascular diseases, chronic inflammation is accompanied by antibody and complement deposits in the heart, suggestive of a true autoimmune response. However, the role of antibody-mediated immune responses in HF progression is less clear. We assessed whether immune cell infiltration and immunoglobulin levels are associated with HF type and disease stage, taking sex differences into account. We found IgG deposits and increased infiltration of immune cells in the affected myocardium of patients with end-stage HF with reduced ejection fraction (HFrEF, n = 20). Circulating levels of IgG1 and IgG3 were elevated in these patients. Furthermore, the percentage of transitional/regulatory B cells was decreased (from 6.9% to 2.4%) compared with healthy controls (n = 5). Similarly, increased levels of circulating IgG1 and IgG3 were observed in men with left ventricular diastolic dysfunction (LVDD, n = 5), possibly an early stage of HF with preserved EF (HFpEF). In conclusion, IgG deposits and infiltrates of immune cells are present in end-stage HFrEF. In addition, both LVDD patients and end-stage HFrEF patients show elevated levels of circulating IgG1 and IgG3, suggesting an antibody-mediated immune response upon cardiac remodelling, which in the early phase of remodelling appear to differ between men and women. These immunoglobulin subclasses might be used as marker for pre-stage HF and its progression. Future identification of auto-antigens might open possibilities for new therapeutic interventions., (© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.)

Published
2019
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43. Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles.

Author

Wang JW, Zhang YN, Sze SK, van de Weg SM, Vernooij F, Schoneveld AH, Tan SH, Versteeg HH, Timmers L, Lam CSP, and de Kleijn DPV

Subjects
Adsorption, Adult, Dextran Sulfate chemistry, Female, Humans, Lipoproteins, LDL isolation & purification, Lipoproteins, VLDL isolation & purification, Male, Blood Coagulation Factors isolation & purification, Blood Component Removal adverse effects, Lipoproteins, LDL chemistry, Lipoproteins, VLDL chemistry
Abstract

Plasma extracellular vesicles (EVs) are lipid membrane vesicles involved in several biological processes including coagulation. Both coagulation and lipid metabolism are strongly associated with cardiovascular events. Lowering very-low- and low-density lipoprotein ((V)LDL) particles via dextran sulphate LDL apheresis also removes coagulation proteins. It remains unknown, however, how coagulation proteins are removed in apheresis. We hypothesize that plasma EVs that contain high levels of coagulation proteins are concomitantly removed with (V)LDL particles by dextran sulphate apheresis. For this, we precipitated (V)LDL particles from human plasma with dextran sulphate and analyzed the abundance of coagulation proteins and EVs in the precipitate. Coagulation pathway proteins, as demonstrated by proteomics and a bead-based immunoassay, were over-represented in the (V)LDL precipitate. In this precipitate, both bilayer EVs and monolayer (V)LDL particles were observed by electron microscopy. Separation of EVs from (V)LDL particles using density gradient centrifugation revealed that almost all coagulation proteins were present in the EVs and not in the (V)LDL particles. These EVs also showed a strong procoagulant activity. Our study suggests that dextran sulphate used in LDL apheresis may remove procoagulant EVs concomitantly with (V)LDL particles, leading to a loss of coagulation proteins from the blood., Competing Interests: The authors declare no conflict of interest.

Published
2017
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