1,186 results on '"Schmidt, U."'
Search Results
2. Particle Physics at the European Spallation Source
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Abele, H., Alekou, A., Algora, A., Andersen, K., Baessler, S., Barron-Palos, L., Barrow, J., Baussan, E., Bentley, P., Berezhiani, Z., Bessler, Y., Bhattacharyya, A. K., Bianchi, A., Bijnens, J., Blanco, C., Kraljevic, N. Blaskovic, Blennow, M., Bodek, K., Bogomilov, M., Bohm, C., Bolling, B., Bouquerel, E., Brooijmans, G., Broussard, L. J., Buchan, O., Burgman, A., Calen, H., Carlile, C. J., Cederkall, J., Chanel, E., Christiansen, P., Cirigliano, V., Collar, J. I., Collins, M., Crawford, C. B., Morales, E. Cristaldo, Cupial, P., D'Alessi, L., Damian, J. I. M., Danared, H., Dancila, D., de Andre, J. P. A. M., Delahaye, J. P., Degenkolb, S., Di Julio, D. D., Dracos, M., Dunne, K., Efthymiopoulos, I., Ekelof, T., Eklund, L., Eshraqi, M., Esteban, I., Fanourakis, G., Farricker, A., Fernandez-Martinez, E., Ferreira, M. J., Fertl, M., Fierlinger, P., Folsom, B., Frank, A., Fratangelo, A., Friman-Gayer, U., Fukuda, T., Fynbo, H . O . U., Sosa, A. Garcia, Gazis, N., Galnander, B., Geralis, Th., Ghosh, M., Gokbulut, G., Gomez-Cadenas, J . J., Gonzalez-Alonso, M., Gonzalez, F., Halic, L., Happe, C., Heil, P., Heinz, A., Herde, H., Holl, M., Jenke, T., Jenssen, M., Jericha, E., Johansson, H. T., Johansson, R., Johansson, T., Kamyshkov, Y., Topaksu, A. Kayis, Kildetoft, B., Kirch, K., Klicek, B., Klinkby, E., Kolevatov, R., Konrad, G., Koziol, M., Krhac, K., Kupsc, A., Lacny, L., Larizgoitia, L., Lewis, C. M., Lindroos, M., Lychagin, E., Lytken, E., Maiano, C., Marciniewski, P., Markaj, G., Markisch, B., Marrelli, C., Martins, C., Meirose, B., Mezzetto, M., Milas, N., Milstead, D., Monrabal, F., Muhrer, G., Nepomuceno, A., Nesvizhevsky, V., Nilsson, T., Novella, P., Oglakci, M., Ohlsson, T., Olvegard, M., Oskarsson, A., Ota, T., Park, J., Patrzalek, D., Perrey, H., Persoz, M., Petkov, G., Piegsa, F. M., Pistillo, C., Poussot, P., Privitera, P., Rataj, B., Ries, D., Rizzi, N., Rosauro-Alcaraz, S., Rozpedzik, D., Saiang, D., Santoro, V., Schmidt, U., Schober, H., Schulthess, I., Silverstein, S., Simon, A., Sina, H., Snamina, J., Snow, W. M., Soldner, T., Stavropoulos, G., Stipcevic, M., Szybinski, B., Takibayev, A., Tang, Z., Tarkeshian, R., Theroine, C., Thorne, J., Terranova, F., Thomas, J., Tolba, T., Torres-Sanchez, P., Trachanas, E., Tsenov, R., Uggerhoj, U. I., Vankova-Kirilova, G., Vassilopoulos, N., Wagner, R., Wang, X., Wildner, E., Wolke, M., Wurtz, J., Yiu, S. C., Yoon, S. G., Young, A. R., Zanini, L., Zejma, J., Zerzion, D., Zimmer, O., Zormpa, O., and Zou, Y.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Nuclear Experiment - Abstract
Presently under construction in Lund, Sweden, the European Spallation Source (ESS) will be the world's brightest neutron source. As such, it has the potential for a particle physics program with a unique reach and which is complementary to that available at other facilities. This paper describes proposed particle physics activities for the ESS. These encompass the exploitation of both the neutrons and neutrinos produced at the ESS for high precision (sensitivity) measurements (searches)., Comment: 121 pages, updated version after referee comments
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- 2022
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3. The Danish Atrial Fibrillation Registry: A Multidisciplinary National Pragmatic Initiative for Monitoring and Supporting Quality of Care Based on Data Retrieved from Administrative Registries
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Frost L, Joensen AM, Dam-Schmidt U, Qvist I, Brinck M, Brandes A, Davidsen U, Pedersen OD, Damgaard D, Mølgaard I, Bedsted R, Damgaard Møller Schlünsen A, Grijota Chousa M, Andersen J, Pedersen AR, Johnsen SP, and Vinter N
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atrial fibrillation ,quality indicators ,quality of care ,Infectious and parasitic diseases ,RC109-216 - Abstract
Lars Frost,1,2 Albert Marni Joensen,3 Ulla Dam-Schmidt,4 Ina Qvist,5 Margit Brinck,6 Axel Brandes,7,8 Ulla Davidsen,4 Ole Dyg Pedersen,9 Dorte Damgaard,10 Inge Mølgaard,11 Robert Bedsted,11 Anders Damgaard Møller Schlünsen,12 Miriam Grijota Chousa,12 Julie Andersen,12 Asger Roer Pedersen,1 Søren Paaske Johnsen,13 Nicklas Vinter1,13 1Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark; 2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 3Department of Cardiology, North Denmark Regional Hospital, Hjørring, Denmark; 4Department of Cardiology, Bispebjerg Hospital, Copenhagen University Hospitals, Copenhagen, Denmark; 5Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; 6Department of Cardiology, Odense University Hospital, Odense, Denmark; 7Department of Cardiology, Esbjerg Hospital – University Hospital of Southern Denmark, Esbjerg, Denmark; 8Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; 9Department of Cardiology, Zealand University Hospital, Roskilde, Denmark; 10Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; 11Patient Representative, Aalborg and Roskilde, Denmark; 12The Danish Clinical Quality Program – National Clinical Registries (RKKP), Aarhus, Denmark; 13Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, DenmarkCorrespondence: Lars Frost, Diagnostic Centre, University Clinic for Development of Innovative Patient Pathways, Silkeborg Regional Hospital; Department of Clinical Medicine, Aarhus University, Falkevej 3, Silkeborg, 8600, Denmark, Tel +45 23988590, Email larfrost@rm.dkAim: The Danish Atrial Fibrillation (AF) Registry monitors and supports improvement of quality of care for all AF patients in Denmark. This report describes the registry’s administrative and organizational structure, data sources, data flow, data analyses, annual reporting, and feedback between the registry, clinicians, and the administrative system. We also report the selection process of the quality indicators and the temporal trends in results from 2017– 2021.Methods and Results: The Danish AF Registry aims for complete registration and monitoring of care for all patients diagnosed with AF in Denmark. Administrative registries provide data on contacts to general practice, contacts to private cardiology practice, hospital contacts, medication prescriptions, updated vital status information, and biochemical test results. The Danish Stroke Registry provides information on stroke events. From 2017 to 2021, the proportion with a reported echocardiography among incident AF patients increased from 39.9% (95% CI: 39.3– 40.6) to 82.6% (95% CI: 82.1– 83.1). The initiation of oral anticoagulant therapy among patients with incident AF and a CHA2DS2-VASc score of ≥ 1 in men and ≥ 2 in women increased from 85.3% (95% CI: 84.6– 85.9) to 90.4% (95% CI: 89.9– 91.0). The 1-year and 2-year persistence increased from 85.2% (95% CI: 84.5– 85.9) to 88.7% (95% CI: 88.0– 89.3), and from 85.4% (95% CI: 84.7– 86.2) to 88.2% (95% CI: 87.5– 88.8), respectively. The 1-year risk of ischemic stroke among prevalent patients with AF decreased from 0.88% (95% CI: 0.83– 0.93) to 0.71% (95% CI: 0.66– 0.75). Variation in clinical performance between the five administrative Danish regions was reduced.Conclusion: Continuous nationwide monitoring of quality indicators for AF originating from administrative registries is feasible and supportive of improvements of quality of care.Keywords: atrial fibrillation, quality indicators, quality of care
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- 2023
4. A Narrative Review of Early Intervention for Eating Disorders: Barriers and Facilitators
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Mills R, Hyam L, and Schmidt U
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anorexia nervosa ,bulimia nervosa ,help-seeking ,treatment seeking ,mental health ,Pediatrics ,RJ1-570 - Abstract
Regan Mills,1 Lucy Hyam,1 Ulrike Schmidt1,2 1Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders (CREW), King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; 2Eating Disorders Outpatient Service, South London and Maudsley NHS Foundation Trust, London, UKCorrespondence: Regan Mills, Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders (CREW), King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK, Email regan.mills@kcl.ac.ukAbstract: Eating disorders (EDs) are serious psychiatric illnesses that typically develop during adolescence and emerging adulthood. Early intervention is important for improved outcomes for young people with EDs, yet help-seeking is low and individuals often have a significantly protracted start to treatment, suggesting that early intervention is not well established in the ED field. Previous reviews on facilitators and barriers to early intervention for EDs largely cover perceived barriers related to patient variables and perspectives, whereas clinician-, service-, and healthcare system-related facilitators and barriers are less frequently reviewed. The aim of this review is to synthesize the literature on barriers to and facilitators of early intervention for EDs, regarding patient-, clinician-, service-, and healthcare system-related factors. A narrative review was conducted by searching for relevant peer-reviewed, English-language articles published up until July 2023 on PubMed and PsychINFO. The search was conducted in two steps. First, key search terms were used to identify existing reviews and meta-analyses on facilitators and barriers to early intervention for EDs. Then, additional search terms were added to search for primary and secondary research on patient/family, clinician, service, and healthcare system-related barriers and facilitators. The identified literature shows that, after overcoming intrinsic, motivational barriers (such as self-stigma, denial, and ambivalence), help-seeking individuals may be met with long service waiting lists and limited treatment options. Despite these barriers, there is ongoing research into early intervention in practice, which aims to reach underserved populations and facilitate early intervention despite high service demands and shortages of trained healthcare professionals. Funding for ED research and services has historically been low, and there is also a research-practice gap. This highlights the need for increased consideration of, and funding for early intervention for EDs, to remove barriers as well as facilitate discussions around how to make early intervention programs scalable and sustainable.Keywords: anorexia nervosa, bulimia nervosa, help-seeking, treatment seeking, mental health
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- 2023
5. A non-depolarizing CuTi neutron supermirror guide for PERC
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Hollering, A., Rebrova, N., Klauser, C., Lauer, Th., Märkisch, B., and Schmidt, U.
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Physics - Instrumentation and Detectors - Abstract
Neutron guides are used to transport slow neutrons from sources to experiments. Conventional neutron supermirror guides use alternating thin layers based on nickel and titanium. Due to the magnetic properties of nickel, their neutron reflection properties are spin-dependent, in particular when exposed to high magnetic fields. Motivated by the requirements of precision experiments on neutron beta decay, we present novel supermirrors based on copper and titanium, which preserve the neutron beam polarization. These show excellent reflectivity and prove to be very stable even when exposed to high temperatures.
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- 2021
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6. Improved determination of the $\beta$-$\overline{\nu}_e$ angular correlation coefficient $a$ in free neutron decay with the $a$SPECT spectrometer
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Beck, M., Guardia, F. Ayala, Baeßler, S., Borg, M., Glück, F., Heil, W., Kahlenberg, J., Klopf, M., Konrad, G., Maisonobe, R., Horta, R. Muñoz, Schmidt, C., Schmidt, U., Simson, M., Soldner, T., Virot, R., Wunderle, A., and Zimmer, O.
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Nuclear Experiment - Abstract
We report on a precise measurement of the electron-antineutrino angular correlation ($a$ coefficient) in free neutron beta-decay from the $a$SPECT experiment. The $a$ coefficient is inferred from the recoil energy spectrum of the protons which are detected in 4$\pi$ by the $a$SPECT spectrometer using magnetic adiabatic collimation with an electrostatic filter. Data are presented from a 100 days run at the Institut Laue Langevin in 2013. The sources of systematic errors are considered and included in the final result. We obtain $a = -0.10430(84)$ which is the most precise measurement of the neutron $a$ coefficient to date. From this, the ratio of axial-vector to vector coupling constants is derived giving $|\lambda| = 1.2677(28)$.
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- 2019
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7. Measurement of the Permanent Electric Dipole Moment of the $^{129}$Xe Atom
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Allmendinger, F., Engin, I., Heil, W., Karpuk, S., Krause, H. -J., Niederländer, B., Offenhäusser, A., Repetto, M., Schmidt, U., and Zimmer, S.
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Physics - Atomic Physics - Abstract
We report on a new measurement of the CP-violating permanent Electric Dipole Moment (EDM) of the neutral $^{129}$Xe atom. Our experimental approach is based on the detection of the free precession of co-located nuclear spin-polarized $^3$He and $^{129}$Xe samples. The EDM measurement sensitivity benefits strongly from long spin coherence times of several hours achieved in diluted gases and homogeneous weak magnetic fields of about 400~nT. A finite EDM is indicated by a change in the precession frequency, as an electric field is periodically reversed with respect to the magnetic guiding field. Our result, $\left(-4.7\pm6.4\right)\cdot 10^{-28}$ ecm, is consistent with zero and is used to place a new upper limit on the $^{129}$Xe EDM: $|d_\text{Xe}|<1.5 \cdot 10^{-27}$ ecm (95% C.L.). We also discuss the implications of this result for various CP-violating observables as they relate to theories of physics beyond the standard model.
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- 2019
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8. Production and Integration of the ATLAS Insertable B-Layer
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Abbott, B., Albert, J., Alberti, F., Alex, M., Alimonti, G., Alkire, S., Allport, P., Altenheiner, S., Ancu, L., Anderssen, E., Andreani, A., Andreazza, A., Axen, B., Arguin, J., Backhaus, M., Balbi, G., Ballansat, J., Barbero, M., Barbier, G., Bassalat, A., Bates, R., Baudin, P., Battaglia, M., Beau, T., Beccherle, R., Bell, A., Benoit, M., Bermgan, A., Bertsche, C., Bertsche, D., de Mendizabal, J. Bilbao, Bindi, F., Bomben, M., Borri, M., Bortolin, C., Bousson, N., Boyd, R., Breugnon, P., Bruni, G., Brossamer, J., Bruschi, M., Buchholz, P., Budun, E., Buttar, C., Cadoux, F., Calderini, G., Caminada, L., Capeans, M., Carney, R., Casse, G., Catinaccio, A., Cavalli-Sforza, M., Červ, M., Cervelli, A., Chau, C., Chauveau, J., Chen, S., Chu, M., Ciapetti, M., Cindro, V., Citterio, M., Clark, A., Cobal, M., Coelli, S., Collot, J., Crespo-Lopez, O., Betta, G. Dalla, Daly, C., D'Amen, G., Dann, N., Dao, V., Darbo, G., DaVia, C., David, P., Debieux, S., Delebecque, P., De Lorenzi, F., de Oliveira, R., Dette, K., Dietsche, W., Di Girolamo, B., Dinu, N., Dittus, F., Diyakov, D., Djama, F., Dobos, D., Dondero, P., Doonan, K., Dopke, J., Dorholt, O., Dube, S., Dzahini, D., Egorov, K., Ehrmann, O., Einsweiler, K., Elles, S., Elsing, M., Eraud, L., Ereditato, A., Eyring, A., Falchieri, D., Falou, A., Fausten, C., Favareto, A., Favre, Y., Feigl, S., Perez, S. Fernandez, Ferrere, D., Fleury, J., Flick, T., Forshaw, D., Fougeron, D., Franconi, L., Gabrielli, A., Gaglione, R., Gallrapp, C., Gan, K., Garcia-Sciveres, M., Gariano, G., Gastaldi, T., Gavrilenko, I., Gaudiello, A., Geffroy, N., Gemme, C., Gensolen, F., George, M., Ghislain, P., Giangiacomi, N., Gibson, S., Giordani, M., Giugni, D., Gjersdal, H., Glitza, K., Gnani, D., Godlewski, J., Gonella, L., Gonzalez-Sevilla, S., Gorelov, I., Gorišek, A., Gössling, C., Grancagnolo, S., Gray, H., Gregor, I., Grenier, P., Grinstein, S., Gris, A., Gromov, V., Grondin, D., Grosse-Knetter, J., Guescini, F., Guido, E., Gutierrez, P., Hallewell, G., Hartman, N., Hauck, S., Hasi, J., Hasib, A., Hegner, F., Heidbrink, S., Heim, T., Heinemann, B., Hemperek, T., Hessey, N., Hetmánek, M., Hinman, R., Hoeferkamp, M., Holmes, T., Hostachy, J., Hsu, S., Hügging, F., Husi, C., Iacobucci, G., Ibragimov, I., Idarraga, J., Ikegami, Y., Ince, T., Ishmukhametov, R., Izen, J. M., Janoška, Z., Janssen, J., Jansen, L., Jeanty, L., Jensen, F., Jentzsch, J., Jezequel, S., Joseph, J., Kagan, H., Kagan, M., Karagounis, M., Kass, R., Kastanas, A., Kenney, C., Kersten, S., Kind, P., Klein, M., Klingenberg, R., Kluit, R., Kocian, M., Koffeman, E., Korchak, O., Korolkov, I., Kostyukhina-Visoven, I., Kovalenko, S., Kretz, M., Krieger, N., Krüger, H., Kruth, A., Kugel, A., Kuykendall, W., La Rosa, A., Lai, C., Lantzsch, K., Lapoire, C., Laporte, D., Lari, T., Latorre, S., Leyton, M., Lindquist, B., Looper, K., Lopez, I., Lounis, A., Lu, Y., Lubatti, H., Maeland, S., Maier, A., Mallik, U., Manca, F., Mandelli, B., Mandić, I., Marchand, D., Marchiori, G., Marx, M., Massol, N., Mättig, P., Mayer, J., Goldrick, G. Mc, Mekkaoui, A., Menouni, M., Menu, J., Meroni, C., Mesa, J., Michal, S., Miglioranzi, S., Mikuž, M., Miucci, A., Mochizuki, K., Monti, M., Moore, J., Morettini, P., Morley, A., Moss, J., Muenstermann, D., Murray, P., Nakamura, K., Nellist, C., Nelson, D., Nessi, M., Nisius, R., Nordberg, M., Nuiry, F., Obermann, T., Ockenfels, W., Oide, H., Oriunno, M., Ould-Saada, F., Padilla, C., Pangaud, P., Parker, S., Pelleriti, G., Pernegger, H., Piacquadio, G., Picazio, A., Pohl, D., Polini, A., Pons, X., Popule, J., Bueso, X. Portell, Potamianos, K., Povoli, M., Puldon, D., Pylypchenko, Y., Quadt, A., Quayle, B., Rarbi, F., Ragusa, F., Rambure, T., Richards, E., Riegel, C., Ristic, B., Rivière, F., Rizatdinova, F., Røhne, O., Rossi, C., Rossi, L., Rovani, A., Rozanov, A., Rubinskiy, I., Rudolph, M., Rummler, A., Ruscino, E., Sabatini, F., Salek, D., Salzburger, A., Sandaker, H., Sannino, M., Sanny, B., Scanlon, T., Schipper, J., Schmidt, U., Schneider, B., Schorlemmer, A., Schroer, N., Schwemling, P., Sciuccati, A., Seidel, S., Seiden, A., Šícho, P., Skubic, P., Sloboda, M., Smith, D., Smith, M., Sood, A., Spencer, E., Stramaglia, M., Strauss, M., Stucci, S., Stugu, B., Stupak, J., Styles, N., Su, D., Takubo, Y., Tassan, J., Teng, P., Teixeira, A., Terzo, S., Therry, X., Todorov, T., Tomášek, M., Toms, K., Travaglini, R., Trischuk, W., Troncon, C., Troska, G., Tsiskaridze, S., Tsurin, I., Tsybychev, D., Unno, Y., Vacavant, L., Verlaat, B., Vigeolas, E., Vogt, M., Vrba, V., Vuillermet, R., Wagner, W., Walkowiak, W., Wang, R., Watts, S., Weber, M., Weingarten, J., Welch, S., Wenig, S., Wensing, M., Wermes, N., Wittig, T., Wittgen, M., Yildizkaya, T., Yang, Y., Yao, W., Yi, Y., Zaman, A., Zaidan, R., Zeitnitz, C., Ziolkowski, M., Zivkovic, V., Zoccoli, A., and Zwalinski, L.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
During the shutdown of the CERN Large Hadron Collider in 2013-2014, an additional pixel layer was installed between the existing Pixel detector of the ATLAS experiment and a new, smaller radius beam pipe. The motivation for this new pixel layer, the Insertable B-Layer (IBL), was to maintain or improve the robustness and performance of the ATLAS tracking system, given the higher instantaneous and integrated luminosities realised following the shutdown. Because of the extreme radiation and collision rate environment, several new radiation-tolerant sensor and electronic technologies were utilised for this layer. This paper reports on the IBL construction and integration prior to its operation in the ATLAS detector., Comment: 90 pages in total. Author list: ATLAS IBL Collaboration, starting page 2. 69 figures, 20 tables. Published in Journal of Instrumentation. All figures available at: https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PLOTS/PIX-2018-001
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- 2018
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9. Response Functions for Detectors in Cosmic Ray Neutron Sensing
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Köhli, M., Schrön, M., and Schmidt, U.
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Physics - Instrumentation and Detectors - Abstract
Cosmic-Ray Neutron Sensing (CRNS) is a novel technique for determining environmental water content by measuring albedo neutrons in the epithermal to fast energy range with moderated neutron detectors. We have investigated the response function of stationary and mobile neutron detectors typically used for environmental research in order to improve the model accuracy for neutron transport studies. Monte Carlo simulations have been performed in order to analyze the detection probability in terms of energy-dependent response and angular sensitivity for different variants of CRNS detectors and converter gases. Our results reveal the sensor's response to neutron energies from 0.1 eV to 1 MeV and highest sensitivity to vertical fluxes. The detector efficiency shows good agreement with reference data from the structurally similar Bonner Spheres. The relative probability of neutrons contributing to the overall integrated signal is especially important in regions with non-uniform albedo fluxes, such as complex terrain or heterogeneous distribution of hydrogen pools., Comment: 18 pages, 7 figures
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- 2018
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10. Precise Measurement of Magnetic Field Gradients from Free Spin Precession Signals of $^{3}$He and $^{129}$Xe Magnetometers
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Allmendinger, F., Blümler, P., Doll, M., Grasdijk, O., Heil, W., Jungmann, K., Karpuk, S., Krause, H. -J., Offenhäusser, A., Repetto, M., Schmidt, U., Sobolev, Yu., Tullney, K., Willmann, L., and Zimmer, S.
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Physics - Atomic Physics ,Physics - Instrumentation and Detectors - Abstract
We report on precise measurements of magnetic field gradients extracted from transverse relaxation rates of precessing spin samples. The experimental approach is based on the free precession of gaseous, nuclear spin polarized $^3$He and $^{129}$Xe atoms in a spherical cell inside a magnetic guiding field of about 400 nT using LT$_C$ SQUIDs as low-noise magnetic flux detectors. The transverse relaxation rates of both spin species are simultaneously monitored as magnetic field gradients are varied. For transverse relaxation times reaching 100 h, the residual longitudinal field gradient across the spin sample could be deduced to be$|\vec{\nabla}B_z|=(5.6 \pm 0.4)$ pT/cm. The method takes advantage of the high signal-to-noise ratio with which the decaying spin precession signal can be monitored that finally leads to the exceptional accuracy to determine magnetic field gradients at the sub pT/cm scale.
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- 2016
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11. Footprint Characteristics Revised for Field-Scale Soil Moisture Monitoring with Cosmic-Ray Neutrons
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Köhli, M., Schrön, M., Zreda, M., Schmidt, U., Dietrich, P., and Zacharias, S.
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Physics - Geophysics ,Physics - Instrumentation and Detectors - Abstract
Cosmic-ray neutron probes are widely used to monitor environmental water content near the surface. The method averages over tens of hectares and is unrivaled in serving representative data for agriculture and hydrological models at the hectometer scale. Recent experiments, however, indicate that the sensor response to environmental heterogeneity is not fully understood. Knowledge of the support volume is a prerequisite for the proper interpretation and validation of hydrogeophysical data. In a previous study, several physical simplifications have been introduced into a neutron transport model in order to derive the characteristics of the cosmic-ray probe's footprint. We utilize a refined source and energy spectrum for cosmic-ray neutrons and simulate their response to a variety of environmental conditions. Results indicate that the method is particularly sensitive to soil moisture in the first tens of meters around the probe, whereas the radial weights are changing dynamically with ambient water. The footprint radius ranges from 130 to 240 m depending on air humidity, soil moisture and vegetation. The moisture-dependent penetration depth of 15 to 83 cm decreases exponentially with distance to the sensor. However, the footprint circle remains almost isotropic in complex terrain with nearby rivers, roads or hill slopes. Our findings suggest that a dynamically weighted average of point measurements is essential for accurate calibration and validation. The new insights will have important impact on signal interpretation, sensor installation, data interpolation from mobile surveys, and the choice of appropriate resolutions for data assimilation into hydrological models., Comment: 57 pages, 10 figures. An edited version of this paper was published by AGU
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- 2016
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12. CASCADE - a multi-layer Boron-10 neutron detection system
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Köhli, M., Klein, M., Allmendinger, F., Perrevoort, A. -K., Schröder, T., Martin, N., Schmidt, C. J., and Schmidt, U.
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Physics - Instrumentation and Detectors - Abstract
The globally increased demand for helium-3 along with the limited availability of this gas calls for the development of alternative technologies for the large ESS instrumentation pool. We report on the CASCADE Project - a novel detection system, which has been developed for the purposes of neutron spin echo spectroscopy. It features 2D spatially resolved detection of thermal neutrons at high rates. The CASCADE detector is composed of a stack of solid boron-10 coated Gas Electron Multiplier foils, which serve both as a neutron converter and as an amplifier for the primary ionization deposited in the standard Argon-CO2 counting gas environment. This multi-layer setup efficiently increases the detection efficiency and serves as a helium-3 alternative. It has furthermore been possible to extract the signal of the charge traversing the stack to identify the very thin conversion layer of about 1 micrometer. This allows the precise determination of the time-of-flight, necessary for the application in MIEZE spin echo techniques., Comment: 8 pages, 11 figures. Submitted for publication in Journal of Physics: Conference Series, Proceedings of the European Conference on Neutron Scattering (ECNS2015)
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- 2016
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13. Qualität von Schulsystemen: theoretische Grundlagen und empirische Befunde
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Betz, Tanja, Feldhoff, Tobias, Bauer, Petra, Schmidt, Uwe, Schmidt-Hertha, Bernhard, Betz, T ( Tanja ), Feldhoff, T ( Tobias ), Bauer, P ( Petra ), Schmidt, U ( Uwe ), Schmidt-Hertha, B ( Bernhard ), Maag Merki, Katharina; https://orcid.org/0000-0002-0215-1684, Wullschleger, Andrea; https://orcid.org/0000-0003-4390-3835, Altrichter, Herbert, Betz, Tanja, Feldhoff, Tobias, Bauer, Petra, Schmidt, Uwe, Schmidt-Hertha, Bernhard, Betz, T ( Tanja ), Feldhoff, T ( Tobias ), Bauer, P ( Petra ), Schmidt, U ( Uwe ), Schmidt-Hertha, B ( Bernhard ), Maag Merki, Katharina; https://orcid.org/0000-0002-0215-1684, Wullschleger, Andrea; https://orcid.org/0000-0003-4390-3835, and Altrichter, Herbert
- Abstract
In diesem Kapitel geht es um den Beitrag der ‚Makroebene‘ des Schulsystems zur Qualität schulischer Prozesse und Ergebnisse. Nach einem Überblick über die Entwicklung des Forschungsbereiches werden im zweiten Abschnitt grundlegende Begriffe geklärt: Wie ist die Makroebene Schulsystem strukturiert und an welchen Merkmalen könnte ihre Qualität abgelesen werden? Danach wird der empirische Forschungsstand an drei Beispielen, der Erforschung von Schulstrukturen, des internationalen Vergleichs von Schüler:innenleistungen sowie der Untersuchung von Governance-Reformen diskutiert.
- Published
- 2024
14. Gravity Resonance Spectroscopy Constrains Dark Energy and Dark Matter Scenarios
- Author
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Jenke, T., Cronenberg, G., Burgdörfer, J., Chizhova, L. A., Geltenbort, P., Ivanov, A. N., Lauer, T., Lins, T., Rotter, S., Saul, H., Schmidt, U., and Abele, H.
- Subjects
General Relativity and Quantum Cosmology ,Nuclear Experiment ,Quantum Physics - Abstract
We report on precision resonance spectroscopy measurements of quantum states of ultracold neutrons confined above the surface of a horizontal mirror by the gravity potential of the Earth. Resonant transitions between several of the lowest quantum states are observed for the first time. These measurements demonstrate, that Newton's inverse square law of Gravity is understood at micron distances on an energy scale of~$10^{-14}$~eV. At this level of precision we are able to provide constraints on any possible gravity-like interaction. In particular, a dark energy chameleon field is excluded for values of the coupling constant~$\beta > 5.8\times10^8$ at~95% confidence level~(C.L.), and an attractive (repulsive) dark matter axion-like spin-mass coupling is excluded for the coupling strength $g_sg_p > 3.7\times10^{-16}$~($5.3\times10^{-16}$)~at a Yukawa length of~$\lambda = 20$~{\textmu}m~(95% (C.L.)., Comment: 5 pages, 4 figures
- Published
- 2014
- Full Text
- View/download PDF
15. New limit on Lorentz and CPT violating neutron spin interactions using a free precession 3He-129Xe co-magnetometer
- Author
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Allmendinger, F., Heil, W., Karpuk, S., Kilian, W., Scharth, A., Schmidt, U., Schnabel, A., Sobolev, Yu., and Tullney, K.
- Subjects
General Relativity and Quantum Cosmology ,Physics - Atomic Physics - Abstract
We report on the search for a CPT and Lorentz invariance violating coupling of the 3He and 129Xe nuclear spins (each largely determined by a valence neutron) to background tensor fields which permeate the universe. Our experimental approach is to measure the free precession of nuclear spin polarized 3He and 129Xe atoms in a homogeneous magnetic guiding field of about 400 nT using LTC SQUIDs as low-noise magnetic flux detectors. As the laboratory reference frame rotates with respect to distant stars, we look for a sidereal modulation of the Larmor frequencies of the co-located spin samples. As a result we obtain an upper limit on the equatorial component of the background field interacting with the spin of the bound neutron bn< 6.7*10^-34 GeV (68% C.L.). Our result improves our previous limit (data measured in 2009) by a factor of 30 and the world's best limit by a factor of 5., Comment: 5 pages, 2 figures. arXiv admin note: text overlap with arXiv:1011.2143
- Published
- 2013
- Full Text
- View/download PDF
16. Early weight gain trajectories in first episode anorexia: predictors of outcome for emerging adults in outpatient treatment
- Author
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Austin, A., Flynn, M., Richards, K. L., Sharpe, H., Allen, K. L., Mountford, V. A., Glennon, D., Grant, N., Brown, A., Mahoney, K., Serpell, L., Brady, G., Nunes, N., Connan, F., Franklin-Smith, M., Schelhase, M., Jones, W. R., Breen, G., and Schmidt, U.
- Published
- 2021
- Full Text
- View/download PDF
17. Particle physics at the European Spallation Source
- Author
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Abele, H, Alekou, A, Algora, A, Andersen, K, Baessler, S, Barron-Palos, L, Barrow, J, Baussan, E, Bentley, P, Berezhiani, Z, Bessler, Y, Bhattacharyya, A, Bianchi, A, Bijnens, J, Blanco, C, Kraljevic, N, Blennow, M, Bodek, K, Bogomilov, M, Bohm, C, Bolling, B, Bouquerel, E, Brooijmans, G, Broussard, L, Buchan, O, Burgman, A, Calen, H, Carlile, C, Cederkall, J, Chanel, E, Christiansen, P, Cirigliano, V, Collar, J, Collins, M, Crawford, C, Morales, E, Cupial, P, D'Alessi, L, Damian, J, Danared, H, Dancila, D, de Andre, J, Delahaye, J, Degenkolb, S, Di Julio, D, Dracos, M, Dunne, K, Efthymiopoulos, I, Ekelof, T, Eklund, L, Eshraqi, M, Esteban, I, Fanourakis, G, Farricker, A, Fernandez-Martinez, E, Ferreira, M, Fertl, M, Fierlinger, P, Folsom, B, Frank, A, Fratangelo, A, Friman-Gayer, U, Fukuda, T, Fynbo, H, Sosa, A, Gazis, N, Galnander, B, Geralis, T, Ghosh, M, Gokbulut, G, Gomez-Cadenas, J, Gonzalez-Alonso, M, Gonzalez, F, Halic, L, Happe, C, Heil, P, Heinz, A, Herde, H, Holl, M, Jenke, T, Jenssen, M, Jericha, E, Johansson, H, Johansson, R, Johansson, T, Kamyshkov, Y, Topaksu, A, Kildetoft, B, Kirch, K, Klicek, B, Klinkby, E, Kolevatov, R, Konrad, G, Koziol, M, Krhac, K, Kupsc, A, Lacny, L, Larizgoitia, L, Lewis, C, Lindroos, M, Lychagin, E, Lytken, E, Maiano, C, Marciniewski, P, Markaj, G, Markisch, B, Marrelli, C, Martins, C, Meirose, B, Mezzetto, M, Milas, N, Milstead, D, Monrabal, F, Muhrer, G, Nepomuceno, A, Nesvizhevsky, V, Nilsson, T, Novella, P, Oglakci, M, Ohlsson, T, Olvegard, M, Oskarsson, A, Ota, T, Park, J, Patrzalek, D, Perrey, H, Persoz, M, Petkov, G, Piegsa, F, Pistillo, C, Poussot, P, Privitera, P, Rataj, B, Ries, D, Rizzi, N, Rosauro-Alcaraz, S, Rozpedzik, D, Saiang, D, Santoro, V, Schmidt, U, Schober, H, Schulthess, I, Silverstein, S, Simon, A, Sina, H, Snamina, J, Snow, W, Soldner, T, Stavropoulos, G, Stipcevic, M, Szybinski, B, Takibayev, A, Tang, Z, Tarkeshian, R, Theroine, C, Thorne, J, Terranova, F, Thomas, J, Tolba, T, Torres-Sanchez, P, Trachanas, E, Tsenov, R, Uggerhoj, U, Vankova-Kirilova, G, Vassilopoulos, N, Wagner, R, Wang, X, Wildner, E, Wolke, M, Wurtz, J, Yiu, S, Yoon, S, Young, A, Zanini, L, Zejma, J, Zerzion, D, Zimmer, O, Zormpa, O, Zou, Y, Abele H., Alekou A., Algora A., Andersen K., Baessler S., Barron-Palos L., Barrow J., Baussan E., Bentley P., Berezhiani Z., Bessler Y., Bhattacharyya A. K., Bianchi A., Bijnens J., Blanco C., Kraljevic N. B., Blennow M., Bodek K., Bogomilov M., Bohm C., Bolling B., Bouquerel E., Brooijmans G., Broussard L. J., Buchan O., Burgman A., Calen H., Carlile C. J., Cederkall J., Chanel E., Christiansen P., Cirigliano V., Collar J. I., Collins M., Crawford C. B., Morales E. C., Cupial P., D'Alessi L., Damian J. I. M., Danared H., Dancila D., de Andre J. P. A. M., Delahaye J. P., Degenkolb S., Di Julio D. D., Dracos M., Dunne K., Efthymiopoulos I., Ekelof T., Eklund L., Eshraqi M., Esteban I., Fanourakis G., Farricker A., Fernandez-Martinez E., Ferreira M. J., Fertl M., Fierlinger P., Folsom B., Frank A., Fratangelo A., Friman-Gayer U., Fukuda T., Fynbo H. O. U., Sosa A. G., Gazis N., Galnander B., Geralis T., Ghosh M., Gokbulut G., Gomez-Cadenas J. J., Gonzalez-Alonso M., Gonzalez F., Halic L., Happe C., Heil P., Heinz A., Herde H., Holl M., Jenke T., Jenssen M., Jericha E., Johansson H. T., Johansson R., Johansson T., Kamyshkov Y., Topaksu A. K., Kildetoft B., Kirch K., Klicek B., Klinkby E., Kolevatov R., Konrad G., Koziol M., Krhac K., Kupsc A., Lacny L., Larizgoitia L., Lewis C. M., Lindroos M., Lychagin E., Lytken E., Maiano C., Marciniewski P., Markaj G., Markisch B., Marrelli C., Martins C., Meirose B., Mezzetto M., Milas N., Milstead D., Monrabal F., Muhrer G., Nepomuceno A., Nesvizhevsky V., Nilsson T., Novella P., Oglakci M., Ohlsson T., Olvegard M., Oskarsson A., Ota T., Park J., Patrzalek D., Perrey H., Persoz M., Petkov G., Piegsa F. M., Pistillo C., Poussot P., Privitera P., Rataj B., Ries D., Rizzi N., Rosauro-Alcaraz S., Rozpedzik D., Saiang D., Santoro V., Schmidt U., Schober H., Schulthess I., Silverstein S., Simon A., Sina H., Snamina J., Snow W. M., Soldner T., Stavropoulos G., Stipcevic M., Szybinski B., Takibayev A., Tang Z., Tarkeshian R., Theroine C., Thorne J., Terranova F., Thomas J., Tolba T., Torres-Sanchez P., Trachanas E., Tsenov R., Uggerhoj U. I., Vankova-Kirilova G., Vassilopoulos N., Wagner R., Wang X., Wildner E., Wolke M., Wurtz J., Yiu S. C., Yoon S. G., Young A. R., Zanini L., Zejma J., Zerzion D., Zimmer O., Zormpa O., Zou Y., Abele, H, Alekou, A, Algora, A, Andersen, K, Baessler, S, Barron-Palos, L, Barrow, J, Baussan, E, Bentley, P, Berezhiani, Z, Bessler, Y, Bhattacharyya, A, Bianchi, A, Bijnens, J, Blanco, C, Kraljevic, N, Blennow, M, Bodek, K, Bogomilov, M, Bohm, C, Bolling, B, Bouquerel, E, Brooijmans, G, Broussard, L, Buchan, O, Burgman, A, Calen, H, Carlile, C, Cederkall, J, Chanel, E, Christiansen, P, Cirigliano, V, Collar, J, Collins, M, Crawford, C, Morales, E, Cupial, P, D'Alessi, L, Damian, J, Danared, H, Dancila, D, de Andre, J, Delahaye, J, Degenkolb, S, Di Julio, D, Dracos, M, Dunne, K, Efthymiopoulos, I, Ekelof, T, Eklund, L, Eshraqi, M, Esteban, I, Fanourakis, G, Farricker, A, Fernandez-Martinez, E, Ferreira, M, Fertl, M, Fierlinger, P, Folsom, B, Frank, A, Fratangelo, A, Friman-Gayer, U, Fukuda, T, Fynbo, H, Sosa, A, Gazis, N, Galnander, B, Geralis, T, Ghosh, M, Gokbulut, G, Gomez-Cadenas, J, Gonzalez-Alonso, M, Gonzalez, F, Halic, L, Happe, C, Heil, P, Heinz, A, Herde, H, Holl, M, Jenke, T, Jenssen, M, Jericha, E, Johansson, H, Johansson, R, Johansson, T, Kamyshkov, Y, Topaksu, A, Kildetoft, B, Kirch, K, Klicek, B, Klinkby, E, Kolevatov, R, Konrad, G, Koziol, M, Krhac, K, Kupsc, A, Lacny, L, Larizgoitia, L, Lewis, C, Lindroos, M, Lychagin, E, Lytken, E, Maiano, C, Marciniewski, P, Markaj, G, Markisch, B, Marrelli, C, Martins, C, Meirose, B, Mezzetto, M, Milas, N, Milstead, D, Monrabal, F, Muhrer, G, Nepomuceno, A, Nesvizhevsky, V, Nilsson, T, Novella, P, Oglakci, M, Ohlsson, T, Olvegard, M, Oskarsson, A, Ota, T, Park, J, Patrzalek, D, Perrey, H, Persoz, M, Petkov, G, Piegsa, F, Pistillo, C, Poussot, P, Privitera, P, Rataj, B, Ries, D, Rizzi, N, Rosauro-Alcaraz, S, Rozpedzik, D, Saiang, D, Santoro, V, Schmidt, U, Schober, H, Schulthess, I, Silverstein, S, Simon, A, Sina, H, Snamina, J, Snow, W, Soldner, T, Stavropoulos, G, Stipcevic, M, Szybinski, B, Takibayev, A, Tang, Z, Tarkeshian, R, Theroine, C, Thorne, J, Terranova, F, Thomas, J, Tolba, T, Torres-Sanchez, P, Trachanas, E, Tsenov, R, Uggerhoj, U, Vankova-Kirilova, G, Vassilopoulos, N, Wagner, R, Wang, X, Wildner, E, Wolke, M, Wurtz, J, Yiu, S, Yoon, S, Young, A, Zanini, L, Zejma, J, Zerzion, D, Zimmer, O, Zormpa, O, Zou, Y, Abele H., Alekou A., Algora A., Andersen K., Baessler S., Barron-Palos L., Barrow J., Baussan E., Bentley P., Berezhiani Z., Bessler Y., Bhattacharyya A. K., Bianchi A., Bijnens J., Blanco C., Kraljevic N. B., Blennow M., Bodek K., Bogomilov M., Bohm C., Bolling B., Bouquerel E., Brooijmans G., Broussard L. J., Buchan O., Burgman A., Calen H., Carlile C. J., Cederkall J., Chanel E., Christiansen P., Cirigliano V., Collar J. I., Collins M., Crawford C. B., Morales E. C., Cupial P., D'Alessi L., Damian J. I. M., Danared H., Dancila D., de Andre J. P. A. M., Delahaye J. P., Degenkolb S., Di Julio D. D., Dracos M., Dunne K., Efthymiopoulos I., Ekelof T., Eklund L., Eshraqi M., Esteban I., Fanourakis G., Farricker A., Fernandez-Martinez E., Ferreira M. J., Fertl M., Fierlinger P., Folsom B., Frank A., Fratangelo A., Friman-Gayer U., Fukuda T., Fynbo H. O. U., Sosa A. G., Gazis N., Galnander B., Geralis T., Ghosh M., Gokbulut G., Gomez-Cadenas J. J., Gonzalez-Alonso M., Gonzalez F., Halic L., Happe C., Heil P., Heinz A., Herde H., Holl M., Jenke T., Jenssen M., Jericha E., Johansson H. T., Johansson R., Johansson T., Kamyshkov Y., Topaksu A. K., Kildetoft B., Kirch K., Klicek B., Klinkby E., Kolevatov R., Konrad G., Koziol M., Krhac K., Kupsc A., Lacny L., Larizgoitia L., Lewis C. M., Lindroos M., Lychagin E., Lytken E., Maiano C., Marciniewski P., Markaj G., Markisch B., Marrelli C., Martins C., Meirose B., Mezzetto M., Milas N., Milstead D., Monrabal F., Muhrer G., Nepomuceno A., Nesvizhevsky V., Nilsson T., Novella P., Oglakci M., Ohlsson T., Olvegard M., Oskarsson A., Ota T., Park J., Patrzalek D., Perrey H., Persoz M., Petkov G., Piegsa F. M., Pistillo C., Poussot P., Privitera P., Rataj B., Ries D., Rizzi N., Rosauro-Alcaraz S., Rozpedzik D., Saiang D., Santoro V., Schmidt U., Schober H., Schulthess I., Silverstein S., Simon A., Sina H., Snamina J., Snow W. M., Soldner T., Stavropoulos G., Stipcevic M., Szybinski B., Takibayev A., Tang Z., Tarkeshian R., Theroine C., Thorne J., Terranova F., Thomas J., Tolba T., Torres-Sanchez P., Trachanas E., Tsenov R., Uggerhoj U. I., Vankova-Kirilova G., Vassilopoulos N., Wagner R., Wang X., Wildner E., Wolke M., Wurtz J., Yiu S. C., Yoon S. G., Young A. R., Zanini L., Zejma J., Zerzion D., Zimmer O., Zormpa O., and Zou Y.
- Abstract
Presently under construction in Lund, Sweden, the European Spallation Source (ESS) will be the world's brightest neutron source. As such, it has the potential for a particle physics program with a unique reach and which is complementary to that available at other facilities. This paper describes proposed particle physics activities for the ESS. These encompass the exploitation of both the neutrons and neutrinos produced at the ESS for high precision (sensitivity) measurements (searches).
- Published
- 2023
18. Probing Physics beyond the Standard Model with He/Xe clock comparison experiments
- Author
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Schmidt, U., Allmendinger, F., Heil, W., Karpuk, S., Scharth, A., Sobolev, Y., Tullney, K., and Zimmer, S.
- Subjects
High Energy Physics - Phenomenology ,Physics - Atomic Physics - Abstract
The comparison of the free precession of co-located 3He-129Xe spins (clock comparison) enables us to search for very tiny nonmagnetic spin interactions. With our setup we could establish new limits for Lorentz invariance violating interactions of spins with a relic background field which permeates the Universe and points in a preferred direction in space., Comment: Presented at the Sixth Meeting on CPT and Lorentz Symmetry, Bloomington, Indiana, June 17-21, 2013
- Published
- 2013
19. Using a rotating magnetic guiding field for the 3He-129Xe-Comagnetometer
- Author
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Allmendinger, F., Schmidt, U., Heil, W., Karpuk, S., Scharth, A., Sobolev, Y., Tullney, K., and Zimmer, S.
- Subjects
High Energy Physics - Phenomenology ,Physics - Atomic Physics - Abstract
Our search for non-magnetic spin-dependent interactions is based on the measurement of free precession of nuclear spin polarized 3He and 129Xe atoms in a homogeneous magnetic guiding field of about 400 nT. We report on our approach to perform an adiabatic rotation of the guiding field that allows us to modulate possible non-magnetic spin-dependent interactions and to find an optimization procedure for long transverse relaxation times T2* both for Helium and Xenon., Comment: Presented at the Sixth Meeting on CPT and Lorentz Symmetry, Bloomington, Indiana, June 17-21, 2013
- Published
- 2013
- Full Text
- View/download PDF
20. A quantized frequency reference in the short-ranged gravity potential and its application for dark matter and dark energy searches
- Author
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Jenke, T., Cronenberg, G., Geltenbort, P., Ivanov, A. N., Lauer, T., Lins, T., Schmidt, U., Saul, H., and Abele, H.
- Subjects
High Energy Physics - Experiment ,General Relativity and Quantum Cosmology ,Nuclear Experiment - Abstract
The evidence for the observation of the Higgs spin-0-boson as a manifestation of a scalar field provides the missing corner stone for the standard model of particles (SM). However, the SM fails to explain the non-visible but gravitationally active part of the universe. Its nature is unknown but the confirmation of a scalar Higgs is giving a boost to scalar-field-theories. So far gravity experiments and observations performed at different distances find no deviation from Newton's gravity law. Therefore dark energy must possess a screening mechanism which suppresses the scalar-mediated fifth force. Our line of attack is a novel gravity experiment with neutrons based on a quantum interference technique. The spectroscopic measurement of quantum states on resonances with an external coupling makes this a powerful search for dark matter and dark energy contributions in the universe. Quantum states in the gravity potential are intimately related to other scalar field or spin-0-bosons if they exist. If the reason is that some undiscovered particle interact with a neutron, this results in a measurable energy shift of quantum states in the gravity potential, because for neutrons the screening effect is absent. We use Gravity Resonance Spectroscopy to measure the energy splitting at the highest level of precision, providing a constraint on any possible new interaction. We obtain a sensitivity of 10^-14 eV. We set an experimental limit on any fifth force, in particular on parameter \beta<2x10^9 at n=3 for the scalar chameleon field, which is improved by a factor of 100 compared to our previous experiment and five orders of magnitude better than from precision tests of atomic spectra. The pseudoscalar axion coupling is constrained to gsgp/\hbar c<3x10^-16 at 20\mu m, which is an improvement by a factor of 30. These results indicate that gravity is understood at this improved level of precision., Comment: 18 pages, 2 tables, 12 figures
- Published
- 2012
21. Limit on Lorentz and CPT violation of the bound Neutron Using a Free Precession 3He/129Xe co-magnetometer
- Author
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Gemmel, C., Heil, W., Karpuk, S., Lenz, K., Sobolev, Yu., Tullney, K., Burghoff, M., Kilian, W., Knappe-Grüneberg, S., Müller, W., Schnabel, A., Seifert, F., Trahms, L., and Schmidt, U.
- Subjects
General Relativity and Quantum Cosmology - Abstract
We report on the search for Lorentz violating sidereal variations of the frequency difference of co-located spin-species while the Earth and hence the laboratory reference frame rotates with respect to a relic background field. The co-magnetometer used is based on the detection of freely precessing nuclear spins from polarized 3He and 129Xe gas samples using SQUIDs as low-noise magnetic flux detectors. As result we can determine the limit for the equatorial component of the background field interacting with the spin of the bound neutron to be bn < 3.7 x 10^{-32} GeV (95 C.L.)., Comment: 5 pages, 4 figures
- Published
- 2010
- Full Text
- View/download PDF
22. Test of Lorentz Symmetry by using a 3He/129Xe Co-Magnetometer
- Author
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Tullney, K., Gemmel, C., Heil, W., Karpuk, S., Lenz, K., Sobolev, Yu., Burghoff, M., Kilian, W., Knappe-Grüneberg, S., Müller, W., Schnabel, A., Seifert, F., Trahms, L., and Schmidt, U.
- Subjects
High Energy Physics - Phenomenology - Abstract
To test Lorentz symmetry we used a 3He/129Xe co-magnetometer. We will give a short summary of our experimental setup and the results of our latest measurements. We obtained preliminary results for the equatorial component of the background field interacting with the spin of the bound neutron: b_n < 3.72 x 10^(-32) GeV (95 C.L.)., Comment: Presented at the Fifth Meeting on CPT and Lorentz Symmetry, Bloomington, Indiana, June 28 - July 2, 2010
- Published
- 2010
- Full Text
- View/download PDF
23. Cubic boron nitride: a new prospective material for ultracold neutron application
- Author
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Sobolev, Yu., Lauer, Th., Borisov, Yu., Daum, M., Fresne, N. du, Goeltl, L., Hampel, G., Heil, W., Knecht, A., Keunecke, M., Kratz, J. V., Lang, T., Meister, M., Plonka-Spehr, Ch., Pokotilovski, Yu., Reichert, P., Schmidt, U., Krist, Th., Wiehl, N., and Zenner, J.
- Subjects
Nuclear Experiment - Abstract
For the first time, the neutron optical wall-potential of natural cubic boron nitride (cBN) was measured at the ultracold neutron (UCN) source of the research reactor TRIGA Mainz using the time-of-flight method (TOF). The samples investigated had a wall-potential of (305 +/- 15) neV. This value is in good agreement with the result extracted from neutron reflectometry data and theoretical expectations. Because of its high critical velocity for UCN and its good dielectric characteristics, cubic boron nitride coatings (isotopically enriched) will be useful for a number of applications in UCN experiments.
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- 2009
- Full Text
- View/download PDF
24. A genome-wide association study of anorexia nervosa
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Boraska, V, Franklin, CS, Floyd, JAB, Thornton, LM, Huckins, LM, Southam, L, Rayner, NW, Tachmazidou, I, Klump, KL, Treasure, J, Lewis, CM, Schmidt, U, Tozzi, F, Kiezebrink, K, Hebebrand, J, Gorwood, P, Adan, RAH, Kas, MJH, Favaro, A, Santonastaso, P, Fernández-Aranda, F, Gratacos, M, Rybakowski, F, Dmitrzak-Weglarz, M, Kaprio, J, Keski-Rahkonen, A, Raevuori, A, Van Furth, EF, Slof-Op 't Landt, MCT, Hudson, JI, Reichborn-Kjennerud, T, Knudsen, GPS, Monteleone, P, Kaplan, AS, Karwautz, A, Hakonarson, H, Berrettini, WH, Guo, Y, Li, D, Schork, NJ, Komaki, G, Ando, T, Inoko, H, Esko, T, Fischer, K, Männik, K, Metspalu, A, Baker, JH, Cone, RD, Dackor, J, DeSocio, JE, Hilliard, CE, O'Toole, JK, Pantel, J, Szatkiewicz, JP, Taico, C, Zerwas, S, Trace, SE, Davis, OSP, Helder, S, Bühren, K, Burghardt, R, de Zwaan, M, Egberts, K, Ehrlich, S, Herpertz-Dahlmann, B, Herzog, W, Imgart, H, Scherag, A, Scherag, S, Zipfel, S, Boni, C, Ramoz, N, Versini, A, Brandys, MK, Danner, UN, de Kovel, C, Hendriks, J, Koeleman, BPC, Ophoff, RA, Strengman, E, van Elburg, AA, Bruson, A, Clementi, M, Degortes, D, Forzan, M, Tenconi, E, Docampo, E, Escaramís, G, Jiménez-Murcia, S, Lissowska, J, Rajewski, A, Szeszenia-Dabrowska, N, Slopien, A, Hauser, J, Karhunen, L, Meulenbelt, I, Slagboom, PE, Tortorella, A, and Maj, M
- Subjects
Anorexia ,Mental Health ,Serious Mental Illness ,Human Genome ,Eating Disorders ,Clinical Research ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Anorexia Nervosa ,Asian People ,Calcineurin ,Carrier Proteins ,Case-Control Studies ,Cullin Proteins ,Female ,Genome-Wide Association Study ,Guanine Nucleotide Exchange Factors ,Humans ,Japan ,Male ,Meta-Analysis as Topic ,Nuclear Proteins ,Polymorphism ,Single Nucleotide ,White People ,anorexia nervosa ,body mass index ,eating disorders ,genome-wide association study ,GWAS ,metabolic ,Wellcome Trust Case Control Consortium 3 ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
- Published
- 2014
25. Experimental demonstration of the stability of Berry's phase for a spin-1/2 particle
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Filipp, S., Klepp, J., Hasegawa, Y., Plonka-Spehr, C., Schmidt, U., Geltenbort, P., and Rauch, H.
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Quantum Physics - Abstract
The geometric phase has been proposed as a candidate for noise resilient coherent manipulation of fragile quantum systems. Since it is determined only by the path of the quantum state, the presence of noise fluctuations affects the geometric phase in a different way than the dynamical phase. We have experimentally tested the robustness of Berry's geometric phase for spin-1/2 particles in a cyclically varying magnetic field. Using trapped polarized ultra-cold neutrons it is demonstrated that the geometric phase contributions to dephasing due to adiabatic field fluctuations vanish for long evolution times., Comment: 4 pages, 4 figures
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- 2008
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26. Preferred-Frame and CP-Violation Tests with Polarized Electrons
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Heckel, B. R., Adelberger, E. G., Cramer, C. E., Cook, T. S., Schlamminger, S., and Schmidt, U.
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High Energy Physics - Experiment - Abstract
We used a torsion pendulum containing $\approx 10^{23}$ polarized electrons to search new interactions that couple to electron spin. We limit CP-violating interactions between the pendulum's electrons and unpolarized matter in the earth or the sun, test for rotation and boost-dependent preferred-frame effects using the earth's rotation and velocity with respect to the entire cosmos, and search for exotic velocity-dependent potentials between polarized electrons and unpolarized matter in the sun and moon. Finally, we find that the gravitational mass of an electron spinning toward the galactic center differs by less than about 1 part in $10^{21}$ from an electron spinning in the opposite direction. As a byproduct of this work, the density of polarized electrons in Sm$ $Co$_5$ was measured to be $(4.19\pm 0.19)\times 10^{22} {\rm cm}^{-3}$ at a field of 9.6 kG., Comment: 54 pages, 18 figures, Submitted to PRD
- Published
- 2008
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27. New CP-violation and preferred-frame tests with polarized electrons
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Heckel, B. R., Cramer, C. E., Cook, T. S., Adelberger, E. G., Schlamminger, S., and Schmidt, U.
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High Energy Physics - Phenomenology - Abstract
We used a torsion pendulum containing $\sim 9 \times 10^{22}$ polarized electrons to search for CP-violating interactions between the pendulum's electrons and unpolarized matter in the laboratory's surroundings or the sun, and to test for preferred-frame effects that would precess the electrons about a direction fixed in inertial space. We find $|g_{\rm P}^e g_{\rm S}^N|/(\hbar c)< 1.7 \times 10^{-36}$ and $|g_{\rm A}^e g_{\rm V}^N|/(\hbar c) < 4.8 \times 10^{-56}$ for $\lambda > 1$AU. Our preferred-frame constraints, interpreted in the Kosteleck\'y framework, set an upper limit on the parameter $|\bm{\tilde {b}}^e| \leq 5.0 \times 10^{-21}$ eV that should be compared to the benchmark value $m_e^2/M_{\rm Planck}= 2 \times 10^{-17}$ eV., Comment: 4 figures, accepted for publication in Physical Review Letters
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- 2006
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28. Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study
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McAlindon, T.E., Schmidt, U., Bugarin, D., Abrams, S., Geib, T., DeGryse, R.E., Kim, K., and Schnitzer, T.J.
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- 2018
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29. Sub-millimeter Tests of the Gravitational Inverse-square Law
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Hoyle, C. D., Kapner, D. J., Heckel, B. R., Adelberger, E. G., Gundlach, J. H., Schmidt, U., and Swanson, H. E.
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High Energy Physics - Phenomenology ,General Relativity and Quantum Cosmology - Abstract
Motivated by a variety of theories that predict new effects, we tested the gravitational 1/r^2 law at separations between 10.77 mm and 137 microns using two different 10-fold azimuthally symmetric torsion pendulums and rotating 10-fold symmetric attractors. Our work improves upon other experiments by up to a factor of about 100. We found no deviation from Newtonian physics at the 95% confidence level and interpret these results as constraints on extensions of the Standard Model that predict Yukawa or power-law forces. We set a constraint on the largest single extra dimension (assuming toroidal compactification and that one extra dimension is significantly larger than all the others) of R <= 160 microns, and on two equal-sized large extra dimensions of R <= 130 microns. Yukawa interactions with |alpha| >= 1 are ruled out at 95% confidence for lambda >= 197 microns. Extra-dimensions scenarios stabilized by radions are restricted to unification masses M >= 3.0 TeV/c^2, regardless of the number of large extra dimensions. We also provide new constraints on power-law potentials V(r)\propto r^{-k} with k between 2 and 5 and on the gamma_5 couplings of pseudoscalars with m <= 10 meV/c^2., Comment: 34 pages, 38 figures
- Published
- 2004
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30. Correlative EDS and Raman Spectroscopy.
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Boese, M, Kelly, S, Meyer, T, and Schmidt, U
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- 2024
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31. Sub-millimeter tests of the gravitational inverse-square law: A search for 'large' extra dimensions
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Hoyle, C. D., Schmidt, U., Heckel, B. R., Adelberger, E. G., Gundlach, J. H., Kapner, D. J., and Swanson, H. E.
- Subjects
High Energy Physics - Phenomenology - Abstract
Motivated by higher-dimensional theories that predict new effects, we tested the gravitational 1/r^2 law at separations ranging down to 218 micrometers using a 10-fold symmetric torsion pendulum and a rotating 10-fold symmetric attractor. We improved previous short-range constraints by up to a factor of 1000 and find no deviations from Newtonian physics., Comment: 4 pages, 5 figures
- Published
- 2000
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32. Genotype-phenotype dilemma in a case of sudden cardiac death with the E1053K mutation and a deletion in the SCN5A gene
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Jenewein, T., Beckmann, B.M., Rose, S., Osterhues, H.H., Schmidt, U., Wolpert, C., Miny, P., Marschall, C., Alders, M., Bezzina, C.R., Wilde, A.A.M., Kääb, S., and Kauferstein, S.
- Published
- 2017
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33. Telemedicine in Neuromuscular Diseases During Covid-19 Pandemic: ERN-NMD European Survey.
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El-Hassar, L., Amara, A., Sanson, B., Lacatus, O., Amir Belhouchet, A., Kroneman, M., Claeys, K., Plançon, J.P., Rodolico, C., Primiano, G., Trojsi, F., Filosto, M., Mongini, T.E., Bortolani, S., Monforte, M., Carraro, E., Maggi, L., Ricci, F., Silani, V., Orsucci, D., Créange, A., Péréon, Y., Stojkovic, T., Beek, N.A. van der, Toscano, A., Pareyson, D., Attarian, S., Bergh, P.Y.K. Van den, Remiche, G., Hoeijmakers, J.G.J., Badrising, U., Voermans, N.C., Kaindl, A.M., Schara-Schmidt, U., Schoser, B., Gazzerro, E., Haberlová, J., Voháňka, S., Pál, E., Molnar, M.J., Leonardis, L., Tournev, I.L., Osorio, A.N., Olivé, M., Muelas, N., Alonso-Perez, J., Plá, F., Visser, Marianne de, Siciliano, G., Sacconi, S., El-Hassar, L., Amara, A., Sanson, B., Lacatus, O., Amir Belhouchet, A., Kroneman, M., Claeys, K., Plançon, J.P., Rodolico, C., Primiano, G., Trojsi, F., Filosto, M., Mongini, T.E., Bortolani, S., Monforte, M., Carraro, E., Maggi, L., Ricci, F., Silani, V., Orsucci, D., Créange, A., Péréon, Y., Stojkovic, T., Beek, N.A. van der, Toscano, A., Pareyson, D., Attarian, S., Bergh, P.Y.K. Van den, Remiche, G., Hoeijmakers, J.G.J., Badrising, U., Voermans, N.C., Kaindl, A.M., Schara-Schmidt, U., Schoser, B., Gazzerro, E., Haberlová, J., Voháňka, S., Pál, E., Molnar, M.J., Leonardis, L., Tournev, I.L., Osorio, A.N., Olivé, M., Muelas, N., Alonso-Perez, J., Plá, F., Visser, Marianne de, Siciliano, G., and Sacconi, S.
- Abstract
Item does not contain fulltext, BACKGROUND: Telemedicine (TM) contributes to bridge the gap between healthcare facilities and patients' homes with neuromuscular disease (NMD) because of mobility issues. However, its deployment is limited due to difficulties evaluating subtle neurological signs such as mild weakness or sensory deficits. The COVID-19 pandemic has disrupted healthcare delivery worldwide, necessitating rapid measures implementation by health care providers (HCPs) to protect patients from acquiring SARS-CoV-2 while maintaining the best care and treatment. OBJECTIVES: Given the challenges faced by remote healthcare assistance of NMD patients, we aim to evaluate the use of TM in NMD during the COVID-19 pandemic. METHODS: Based on the Model for Assessment-of-Telemedicine-Applications (MAST), we conducted a survey amongst clinicians of the ERN EURO NMD (European-Reference-Network-for-Rare-Neuromuscular-Diseases). RESULTS: Based on 42 responses over 76 expected ones, our results show that the COVID-19 pandemic significantly increased the number of HCPs using TM (from 60% to 100%). The TM types most used during the COVID-19 period are teleconsultation and consultation by phone, particularly in the context of symptoms worsening in NMD patients with COVID-19 infection. Most European HCPs were satisfied when using TM but as a complementary option to physical consultations. Many responses addressed the issue of technical aspects needing improvement, particularly for elderly patients who need caregivers' assistance for accessing the TM platform. CONCLUSIONS: TM has been essential during COVID-19, but its use still presents some limitations for NMD patients with cognitive deficits or for first-time diagnosis. Thus, TM should be used as complement to, rather than substitute, for face-to-face consultations.
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- 2023
34. Safety and efficacy of tamoxifen in boys with Duchenne muscular dystrophy (TAMDMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
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Henzi, B.C., Schmidt, S., Nagy, S., Rubino-Nacht, D., Schaedelin, S., Putananickal, N., Stimpson, G., Amthor, H., Childs, A.M., Deconinck, N., Groot, I.J.M. de, Horrocks, I., Houwen-van Opstal, S.L.S., Laugel, V., Lopez Lobato, M., Madruga Garrido, M., Nascimento Osorio, A., Schara-Schmidt, U., Spinty, S., Moers, A. von, Lawrence, F., Hafner, P., Dorchies, O.M., Fischer, D., Henzi, B.C., Schmidt, S., Nagy, S., Rubino-Nacht, D., Schaedelin, S., Putananickal, N., Stimpson, G., Amthor, H., Childs, A.M., Deconinck, N., Groot, I.J.M. de, Horrocks, I., Houwen-van Opstal, S.L.S., Laugel, V., Lopez Lobato, M., Madruga Garrido, M., Nascimento Osorio, A., Schara-Schmidt, U., Spinty, S., Moers, A. von, Lawrence, F., Hafner, P., Dorchies, O.M., and Fischer, D.
- Abstract
Item does not contain fulltext, BACKGROUND: Drug repurposing could provide novel treatment options for Duchenne muscular dystrophy. Because tamoxifen-an oestrogen receptor regulator-reduced signs of muscular pathology in a Duchenne muscular dystrophy mouse model, we aimed to assess the safety and efficacy of tamoxifen in humans as an adjunct to corticosteroid therapy over a period of 48 weeks. METHODS: We did a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial at 12 study centres in seven European countries. We enrolled ambulant boys aged 6·5-12·0 years with a genetically confirmed diagnosis of Duchenne muscular dystrophy and who were on stable corticosteroid treatment for more than 6 months. Exclusion criteria included ophthalmological disorders, including cataracts, and haematological disorders. We randomly assigned (1:1) participants using an online randomisation tool to either 20 mg tamoxifen orally per day or matched placebo, stratified by centre and corticosteroid intake. Participants, caregivers, and clinical investigators were masked to treatment assignments. Tamoxifen was taken in addition to standard care with corticosteroids, and participants attended study visits for examinations every 12 weeks. The primary efficacy outcome was the change from baseline to week 48 in scores on the D1 domain of the Motor Function Measure in the intention-to-treat population (defined as all patients who fulfilled the inclusion criteria and began treatment). This study is registered with ClinicalTrials.gov (NCT03354039) and is completed. FINDINGS: Between May 24, 2018, and Oct 14, 2020, 95 boys were screened for inclusion, and 82 met inclusion criteria and were initially enrolled into the study. Three boys were excluded after initial screening due to cataract diagnosis or revoked consent directly after screening, but before randomisation. A further boy assigned to the placebo group did not begin treatment. Therefore, 40 individuals assigned tamoxifen and 38 allocated placebo were inc
- Published
- 2023
35. URANOS v1.0 – the Ultra Rapid Adaptable Neutron-Only Simulation for environmental research
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Köhli, M., Schrön, Martin, Zacharias, Steffen, Schmidt, U., Köhli, M., Schrön, Martin, Zacharias, Steffen, and Schmidt, U.
- Abstract
The understanding of neutron transport by Monte Carlo simulations led to major advancements towards precise interpretation of measurements. URANOS (Ultra Rapid Neutron-Only Simulation) is a free software package which has been developed in the last few years in cooperation with particle physics and environmental sciences, specifically for the purposes of cosmic-ray neutron sensing (CRNS). Its versatile user interface and input/output scheme tailored for CRNS applications offers hydrologists straightforward access to model individual scenarios and to directly perform advanced neutron transport calculations. The geometry can be modeled layer-wise, whereas in each layer a voxel geometry is extruded using a two-dimensional map from pixel images representing predefined materials and allowing for the construction of objects on the basis of pixel graphics without a three-dimensional editor. It furthermore features predefined cosmic-ray neutron spectra and detector configurations and also allows for a replication of important site characteristics of study areas – from a small pond to the catchment scale. The simulation thereby gives precise answers to questions like from which location do neutrons originate? How do they propagate to the sensor? What is the neutron's response to certain environmental changes? In recent years, URANOS has been successfully employed by a number of studies, for example, to calculate the cosmic-ray neutron footprint, signals in complex geometries like mobile applications on roads, urban environments and snow patterns.
- Published
- 2023
36. Skin blister formation together with patterned intradermal hematoma: A special type of tire mark injury in victims run over by a wheel
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Pircher, R., Epting, T., Schmidt, U., Geisenberger, D., Pollak, S., and Kramer, L.
- Published
- 2015
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37. Assessment and management of medical emergencies in eating disorders: guidance for GPs
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Mughal, F, de Lusignan, S, Schmidt, U, and Bhui, K
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Family Practice - Published
- 2023
38. Spotting and supporting eating disorders in school: recommendations from school staff
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Knightsmith, P., Treasure, J., and Schmidt, U.
- Published
- 2013
39. Escalation of methamphetamine-related crime and fatalities in the Dresden region, Germany, between 2005 and 2011
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Pietsch, J., Paulick, T., Schulz, K., Flössel, U., Engel, A., Schmitter, S., and Schmidt, U.
- Published
- 2013
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40. Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK
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A Martineau, Brett N. Adey, Gerome Breen, Papadia S, Maughan B, Alicia J. Peel, Jessica Mundy, Stirrups K, Matthew Richardson, Linger R, Ammar Al-Chalabi, Holt H, Melanie J. Davies, David Veale, Alish B. Palmos, Kirstin L. Purves, Y. Lin, Huebel C, Bristow S, Katherine N. Thompson, Evangelos Vassos, Ward C, Bradley J, Young Ks, Colette R. Hirsch, ter Kuile A, Gursharan Kalsi, Kingston N, Andrea Danese, Timothy R Nicholson, Georgina Krebs, Chaudhuri Kr, Sharon Stevelink, Thalia C. Eley, Bright S, Christopher Rayner, Pollak T, Chinnery P, Matthew Hotopf, Lee Yt, York K, Hegemann L, Dina Monssen, Moukhtarian T, Christine E. Parsons, Henry C. Rogers, and Schmidt U
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Psychiatry and Mental health ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Pandemic ,Medicine ,Anxiety ,medicine.symptom ,business ,Psychiatry ,Applied Psychology ,Depression (differential diagnoses) - Abstract
Background The impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health is still being unravelled. It is important to identify which individuals are at greatest risk of worsening symptoms. This study aimed to examine changes in depression, anxiety and post-traumatic stress disorder (PTSD) symptoms using prospective and retrospective symptom change assessments, and to find and examine the effect of key risk factors. Method Online questionnaires were administered to 34 465 individuals (aged 16 years or above) in April/May 2020 in the UK, recruited from existing cohorts or via social media. Around one-third (n = 12 718) of included participants had prior diagnoses of depression or anxiety and had completed pre-pandemic mental health assessments (between September 2018 and February 2020), allowing prospective investigation of symptom change. Results Prospective symptom analyses showed small decreases in depression (PHQ-9: −0.43 points) and anxiety [generalised anxiety disorder scale – 7 items (GAD)-7: −0.33 points] and increases in PTSD (PCL-6: 0.22 points). Conversely, retrospective symptom analyses demonstrated significant large increases (PHQ-9: 2.40; GAD-7 = 1.97), with 55% reported worsening mental health since the beginning of the pandemic on a global change rating. Across both prospective and retrospective measures of symptom change, worsening depression, anxiety and PTSD symptoms were associated with prior mental health diagnoses, female gender, young age and unemployed/student status. Conclusions We highlight the effect of prior mental health diagnoses on worsening mental health during the pandemic and confirm previously reported sociodemographic risk factors. Discrepancies between prospective and retrospective measures of changes in mental health may be related to recall bias-related underestimation of prior symptom severity.
- Published
- 2022
41. Two-scale elastic parameter identification from noisy macroscopic data
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Schmidt, U., Steinmann, P., and Mergheim, J.
- Published
- 2016
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42. How to Optimise the Collection of Patient-Reported Outcomes in the Context of a Specific Disease such as Eating Disorders
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Schmidt, U., primary
- Published
- 2022
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43. Micro-to-macro transitions for continua with surface structure at the microscale
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Javili, A., McBride, A., Mergheim, J., Steinmann, P., and Schmidt, U.
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- 2013
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44. Mitochondrial diseases mimicking autoimmune diseases of the CNS and good response to steroids initially
- Author
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Marina, A. Della, Bertolini, A., Wegener-Panzer, A., Flotats-Bastardas, M., Reinhardt, T., Naggar, I. El, Distelmaier, F., Blaschek, A., Schara-Schmidt, U., Brunet, T., Wagner, M., Smirnov, D., Prokisch, H., Wortmann, S.B., Rostasy, K., Marina, A. Della, Bertolini, A., Wegener-Panzer, A., Flotats-Bastardas, M., Reinhardt, T., Naggar, I. El, Distelmaier, F., Blaschek, A., Schara-Schmidt, U., Brunet, T., Wagner, M., Smirnov, D., Prokisch, H., Wortmann, S.B., and Rostasy, K.
- Abstract
Item does not contain fulltext, INTRODUCTION: Neuroimmunological diseases such as autoimmune encephalitis (AE) or acquired demyelinating syndromes (ADS), can present with neurological symptoms and imaging features that are indistinguishable from mitochondrial diseases (MD) in particular at initial presentation. METHODS: Retrospective analysis of the clinical, laboratory and neuroimaging features of five patients who presented with signs of a neuroimmunological disease but all had pathological pathogenic variants in genes related to mitochondrial energy metabolism. RESULTS: Four patients presented with an acute neurological episode reminiscent of a possible AE and one patient with a suspected ADS at initial presentation. MRI findings were compatible with neuroimmunological diseases in all patients. In two children cerebrospinal fluid (CSF) studies revealed a mildly elevated cell count, two had elevated CSF lactate, none had oligoclonal bands (OCBs). All patients improved rapidly with intravenous steroids or immunoglobulins. Four patients had one or more relapses. Three patients showed worsening of their neurological symptoms with subsequent episodes and one patient died. Relapses in conjunction with new and progressive neurological symptoms, led to additional work-up which finally resulted in different genetic diagnosis of MD in all patients (MT-TL1, MT-ND5, APOA1-BP, HPDL, POLG). DISCUSSION: We would like to draw attention to a subset of patients with MD initially presenting with signs and symptoms mimicking neuroimmunological. Absence of CSF pleocytosis, elevated CSF lactate and progressive, relapsing course should trigger further (genetic) investigations in search of a MD even in patients with good response initially to immunomodulating therapies.
- Published
- 2022
45. Vis-NIR spectral data and chemical properties of humus samples from forest soils in Saxony
- Author
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Thomas, Felix, Pohle, Marco, Schmidt, U., Werban, Ulrike ; orcid:0000-0003-4700-5258, Thomas, Felix, Pohle, Marco, Schmidt, U., and Werban, Ulrike ; orcid:0000-0003-4700-5258
- Published
- 2022
46. Cathepsin D as biomarker in CSF of nusinersen-treated patients with spinal muscular atrophy
- Author
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Schorling, D., Koelbel, H., Hentschel, A., Pechmann, A., Meyer, N., Wirth, B., Rombo, R., Sickmann, A., Kirschner, J., Schara-Schmidt, U., Lochmueller, H., Roos, A., Schorling, D., Koelbel, H., Hentschel, A., Pechmann, A., Meyer, N., Wirth, B., Rombo, R., Sickmann, A., Kirschner, J., Schara-Schmidt, U., Lochmueller, H., and Roos, A.
- Published
- 2022
47. Introduction of 12 novel pathogenic DMD variants, associated phenotypes and studies of dystrophin and MAST1 abundances
- Author
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Gangfuss, A., Neuhoff, K., Hentschel, A., Kohlschmidt, N., Koelbel, H., Schara Schmidt, U., and Roos, A.
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Medizin - Published
- 2022
48. Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy : A Randomized Clinical Trial
- Author
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Guglieri, M., Bushby, K., Mcdermott, M. P., Hart, K. A., Tawil, R., Martens, W. B., Herr, B. E., Mccoll, E., Speed, C., Wilkinson, J., Kirschner, J., King, W. M., Eagle, M., Brown, M. W., Willis, T., Griggs, R. C., Straub, V., van Ruiten, H., Childs, A. -M., Ciafaloni, E., Shieh, P. B., Spinty, S., Maggi, L., Baranello, G., Butterfield, R. J., Horrocks, I. A., Roper, H., Alhaswani, Z., Flanigan, K. M., Kuntz, N. L., Manzur, A., Darras, B. T., Kang, P. B., Morrison, L., Krzesniak-Swinarska, M., Mah, J. K., Mongini, T. E., Ricci, F., von der Hagen, M., Finkel, R. S., O'Reardon, K., Wicklund, M., Kumar, A., Mcdonald, C. M., Han, J. J., Joyce, N., Henricson, E. K., Schara-Schmidt, U., Gangfuss, A., Wilichowski, E., Barohn, R. J., Statland, J. M., Campbell, C., Vita, G., Vita, G. L., Howard, J. F., Hughes, I., Mcmillan, H. J., Pegoraro, E., Bello, L., Burnette, W. B., Thangarajh, M., Chang, T., Schara-Schmidt, Ulrike (Beitragende*r), and Gangfuss, Andrea (Beitragende*r)
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Male ,Medizin ,General Medicine ,Duchenne ,Muscular Dystrophy, Duchenne ,Child ,Child, Preschool ,Female ,Humans ,Pregnenediones ,Glucocorticoids ,Prednisone ,Muscular Dystrophy ,Preschool ,Original Investigation - Abstract
IMPORTANCE: Corticosteroids improve strength and function in boys with Duchenne muscular dystrophy. However, there is uncertainty regarding the optimum regimen and dosage. OBJECTIVE: To compare efficacy and adverse effects of the 3 most frequently prescribed corticosteroid regimens in boys with Duchenne muscular dystrophy. DESIGN, SETTING, AND PARTICIPANTS: Double-blind, parallel-group randomized clinical trial including 196 boys aged 4 to 7 years with Duchenne muscular dystrophy who had not previously been treated with corticosteroids; enrollment occurred between January 30, 2013, and September 17, 2016, at 32 clinic sites in 5 countries. The boys were assessed for 3 years (last participant visit on October 16, 2019). INTERVENTIONS: Participants were randomized to daily prednisone (0.75 mg/kg) (n = 65), daily deflazacort (0.90 mg/kg) (n = 65), or intermittent prednisone (0.75 mg/kg for 10 days on and then 10 days off) (n = 66). MAIN OUTCOMES AND MEASURES: The global primary outcome comprised 3 end points: rise from the floor velocity (in rise/seconds), forced vital capacity (in liters), and participant or parent global satisfaction with treatment measured by the Treatment Satisfaction Questionnaire for Medication (TSQM; score range, 0 to 100), each averaged across all study visits after baseline. Pairwise group comparisons used a Bonferroni-adjusted significance level of .017. RESULTS: Among the 196 boys randomized (mean age, 5.8 years [SD, 1.0 years]), 164 (84%) completed the trial. Both daily prednisone and daily deflazacort were more effective than intermittent prednisone for the primary outcome (P
- Published
- 2022
49. Komplexe Quetschverletzung rechte Hand und Unterarm durch ein 250 kg schweres Metallwerkstück
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Wünsch, K, Zhu, Z, Schmidt, C, Schmidt, U, and Schütz, L
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ddc: 610 ,Medicine and health - Abstract
Fragestellung: Zur Versorgung kommt am 04.07.2017 ein 1993 geborener Mann (BG-Unfall) mit komplexer Quetschverletzung rechte Hand/Unterarm. Es bestehen grob verschmutzte Riss-Quetschwunden mit streifigen Hautnekrosen sowie in Höhe des Ligamentum carpi transversum eine vollständige Durchtrennung [zum vollständigen Text gelangen Sie über die oben angegebene URL]
- Published
- 2021
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- View/download PDF
50. Comparison of Different Greenhouse Systems and Their Impacts on Plant Responses of Tomatoes
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Dannehl, Dennis, Josuttis, M., Huyskens-Keil, S., Ulrichs, C., and Schmidt, U.
- Published
- 2014
- Full Text
- View/download PDF
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