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1. A prospective, randomized, controlled, multicenter trial for secondary prevention in patients with chronic coronary syndrome using a smartphone application for digital therapy - The CHANGE study protocol

Author

Düsing, Philip, primary, Eckardt, Irina, additional, Schirmer, Stephan H, additional, Sinning, Jan-Malte, additional, Werner, Nikos, additional, Bönner, Florian, additional, Krogmann, Alexander, additional, Schäfer, Sebastian, additional, Sedaghat, Alexander, additional, Müller, Cornelius, additional, Nickenig, Georg, additional, and Zietzer, Andreas, additional

Published
2023
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5. Chemokine CCL9 Is Upregulated Early in Chronic Kidney Disease and Counteracts Kidney Inflammation and Fibrosis

Author

Hemmers, Christian, primary, Schulte, Corinna, additional, Wollenhaupt, Julia, additional, Wong, Dickson W. L., additional, Harlacher, Eva, additional, Orth-Alampour, Setareh, additional, Klinkhammer, Barbara Mara, additional, Schirmer, Stephan H., additional, Böhm, Michael, additional, Marx, Nikolaus, additional, Speer, Thimoteus, additional, Boor, Peter, additional, Jankowski, Joachim, additional, and Noels, Heidi, additional

Published
2022
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8. Plasma biomarkers outperform echocardiographic measurements for cardiovascular risk prediction in kidney transplant recipients: results of the HOME ALONE study.

Author

Emrich, Insa E, Scheuer, Anja L, Rogacev, Kyrill S, Mahfoud, Felix, Wagenpfeil, Stefan, Fliser, Danilo, Schirmer, Stephan H, Böhm, Michael, and Heine, Gunnar H

Subjects
BRAIN natriuretic factor, KIDNEY transplantation, ECHOCARDIOGRAPHY, CARDIOVASCULAR diseases risk factors, NATRIURETIC peptides
Abstract

Background Since kidney transplant recipients (KTRs) have a high cardiovascular disease burden, adequate risk prediction is of importance. Whether echocardiographic parameters and plasma biomarkers, natriuretic peptides [N-terminal pro-B-type natriuretic peptide (NT-proBNP)] and troponin T provide complementary or overlapping prognostic information on cardiovascular events remains uncertain. Methods The prospective Heterogeneity of Monocytes and Echocardiography Among Allograft Recipients in Nephrology (HOME ALONE) study followed 177 KTRs for 5.4 ± 1.7 years. Predefined endpoints were hospitalization for acute decompensated heart failure or all-cause death (HF/D) and major atherosclerotic cardiovascular events or all-cause death (MACE/D). At baseline, plasma NT-proBNP, plasma troponin T and echocardiographic parameters [left atrial volume index, left ventricular (LV) mass index, LV ejection fraction, and LV filling pressure] were assessed. Results Among all echocardiographic and plasma biomarkers measured, only NT-proBNP was consistently associated with HF/D in univariate and multivariate {third versus first tertile: hazard ratio [HR] 4.20 [95% confidence interval (CI) 1.02–17.27]} analysis, and only troponin T was consistently associated with MACE/D in univariate and multivariate [third versus first tertile: HR 8.15 (95% CI 2.75–24.18)] analysis. Conclusion Our data suggest that plasma biomarkers are robust and independent predictors of heart failure and atherosclerotic cardiovascular events after kidney transplantation, whereas standard echocardiographic follow-up does not add to risk prediction. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis

Author

van der Laan, Anja M., Schirmer, Stephan H., de Vries, Margreet R., Koning, Jasper J., Volger, Oscar L., Fledderus, Joost O., Bastiaansen, Antonius J.N.M., Hollander, Maurits R., Baggen, Josefien M., Koch, Karel T., Baan, Jan, Jr, Henriques, José P., van der Schaaf, René J., Vis, Marije M., Mebius, Reina E., van der Pouw Kraan, Tineke C., Quax, Paul H., Piek, Jan J., Horrevoets, Anton J., and van Royen, Niels

Published
2012
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17. Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients

Author

van der Laan Anja M, Leyen Thomas A, Baggen Josefien M, Moerland Perry D, Fledderus Joost O, Schirmer Stephan H, van der Pouw Kraan Tineke CTM, Piek Jan J, van Royen Niels, and Horrevoets Anton JG

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Circulating CD34+ progenitor cells have the potential to differentiate into a variety of cells, including endothelial cells. Knowledge is still scarce about the transcriptional programs used by CD34+ cells from peripheral blood, and how these are affected in coronary artery disease (CAD) patients. Results We performed a whole genome transcriptome analysis of CD34+ cells, CD4+ T cells, CD14+ monocytes, and macrophages from 12 patients with CAD and 11 matched controls. CD34+ cells, compared to other mononuclear cells from the same individuals, showed high levels of KRAB box transcription factors, known to be involved in gene silencing. This correlated with high expression levels in CD34+ cells for the progenitor markers HOXA5 and HOXA9, which are known to control expression of KRAB factor genes. The comparison of expression profiles of CD34+ cells from CAD patients and controls revealed a less naïve phenotype in patients' CD34+ cells, with increased expression of genes from the Mitogen Activated Kinase network and a lowered expression of a panel of histone genes, reaching levels comparable to that in more differentiated circulating cells. Furthermore, we observed a reduced expression of several genes involved in CXCR4-signaling and migration to SDF1/CXCL12. Conclusions The altered gene expression profile of CD34+ cells in CAD patients was related to activation/differentiation by a retinoic acid-induced differentiation program. These results suggest that circulating CD34+ cells in CAD patients are programmed by retinoic acid, leading to a reduced capacity to migrate to ischemic tissues.

Published
2010
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21. Clot Structure: A Potent Mortality Risk Factor in Patients on Hemodialysis

Author

Schuett, Katharina, primary, Savvaidis, Anna, additional, Maxeiner, Sebastian, additional, Lysaja, Katharina, additional, Jankowski, Vera, additional, Schirmer, Stephan H., additional, Dimkovic, Nada, additional, Boor, Peter, additional, Kaesler, Nadine, additional, Dekker, Friedo W., additional, Floege, Jürgen, additional, Marx, Nikolaus, additional, and Schlieper, Georg, additional

Published
2017
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22. Echocardiographic criteria to detect unicuspid aortic valve morphology.

Author

Ewen, Sebastian, Karliova, Irem, Weber, Petra, Schirmer, Stephan H, Abdul-Khaliq, Hashim, Schöpe, Jakob, Mahfoud, Felix, and Schäfers, Hans-Joachim

Subjects
AORTIC stenosis, MITRAL valve surgery, TRICUSPID valve surgery, AORTIC valve abnormalities, AORTIC valve, CONFIDENCE intervals, ECHOCARDIOGRAPHY, PREOPERATIVE care, COMORBIDITY, BODY mass index, ANATOMY, DIAGNOSIS
Abstract

Aims Unicuspid aortic valve (UAV) is a rare congenital malformation associated with severe aortic stenosis or regurgitation. This study aimed to systematically determine echocardiographic criteria to identify UAV. Methods and results All patients underwent a preoperative baseline examination, including echocardiography. A total of 69 patients with intraoperatively confirmed UAV underwent an aortic valve repair procedure between August 2001 and May 2011. To compare the findings of UAV cases with those of other valve morphologies, we examined 99 consecutive patients with a bicuspid aortic valve (BAV) and 103 consecutive patients with a tricuspid aortic valve (TAV) undergoing isolated aortic valve surgery before May 2016. The mean age of the 271 patients was 44.2 ± 12.8 years; 85% were male, with a mean body mass index of 26.2 ± 4.0 kg/m2. Patients with UAV were younger and had fewer co-morbidities than patients with BAV or TAV, respectively. The major criteria for the echocardiographic diagnosis of UAV were defined based on our preoperative examination as follows: (i) single commissural attachment zone, (ii) rounded, leaflet-free edge on the opposite side of the commissural attachment zone, (iii) eccentric valvular orifice during systole, and (iv) patient age <20 years and mean transvalvular gradient >15 mmHg. The minor criteria were defined as an associated thoracic aortopathy and age <40 years. Three out of the four major criteria or two out of the four major criteria and one minor criterion were met in all patients with UAV and in none of the patients with BAV or TAV. Associated 95% confidence intervals were calculated for each estimate of sensitivity (94.7–100%) and specificity (98.1–100%), indicating that an adequate number of patients were included in each of the three groups. Conclusion The proposed echocardiographic score appears to be a specific and sensitive method to distinguish UAV from BAV and TAV. [ABSTRACT FROM AUTHOR]

Published
2019
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23. Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats

Author

Hohl, Mathias, primary, Linz, Dominik, additional, Fries, Peter, additional, Müller, Andreas, additional, Stroeder, Jonas, additional, Urban, Daniel, additional, Speer, Thimoteus, additional, Geisel, Jürgen, additional, Hummel, Björn, additional, Laufs, Ulrich, additional, Schirmer, Stephan H., additional, Böhm, Michael, additional, and Mahfoud, Felix, additional

Published
2016
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24. Reply

Author

Böhm, Michael, primary, Ezekowitz, Michael D., additional, Connolly, Stuart J., additional, Eikelboom, John W., additional, Hohnloser, Stefan H., additional, Reilly, Paul A., additional, Schumacher, Helmut, additional, Brueckmann, Martina, additional, Schirmer, Stephan H., additional, Kratz, Mario T., additional, Yusuf, Salim, additional, Diener, Hans-Christoph, additional, Hijazi, Ziad, additional, and Wallentin, Lars, additional

Published
2015
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25. Reply

Author

Schirmer, Stephan H., primary, Linz, Dominik, additional, Mahfoud, Felix, additional, and Böhm, Michael, additional

Published
2015
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28. Changes in Renal Function in Patients With Atrial Fibrillation

Author

Böhm, Michael, primary, Ezekowitz, Michael D., additional, Connolly, Stuart J., additional, Eikelboom, John W., additional, Hohnloser, Stefan H., additional, Reilly, Paul A., additional, Schumacher, Helmut, additional, Brueckmann, Martina, additional, Schirmer, Stephan H., additional, Kratz, Mario T., additional, Yusuf, Salim, additional, Diener, Hans-Christoph, additional, Hijazi, Ziad, additional, and Wallentin, Lars, additional

Published
2015
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32. Abstract 18332: Clinical Parameters Associated with the Development of the Coronary Collateral Circulation in Patients with a Chronic Total Occlusion

Author

van der Hoeven, Nina W, primary, Teunissen, Paul F, additional, Delewi, Ronak, additional, Schirmer, Stephan H, additional, Traupe, Tobias, additional, van der Pouw-Kraan, Tineke, additional, Tijssen, Jan P, additional, Piek, Jan J, additional, Werner, Gerard S, additional, Seiler, Christian, additional, and van Royen, Niels, additional

Published
2012
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35. Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis

Author

van der Laan, Anja M., primary, Schirmer, Stephan H., additional, de Vries, Margreet R., additional, Koning, Jasper J., additional, Volger, Oscar L., additional, Fledderus, Joost O., additional, Bastiaansen, Antonius J.N.M., additional, Hollander, Maurits R., additional, Baggen, Josefien M., additional, Koch, Karel T., additional, Baan, Jan, additional, Henriques, José P., additional, van der Schaaf, René J., additional, Vis, Marije M., additional, Mebius, Reina E., additional, van der Pouw Kraan, Tineke C., additional, Quax, Paul H., additional, Piek, Jan J., additional, Horrevoets, Anton J., additional, and van Royen, Niels, additional

Published
2011
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36. Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis

Author

Schirmer, Stephan H., primary, Degen, Achim, additional, Baumhäkel, Magnus, additional, Custodis, Florian, additional, Schuh, Lisa, additional, Kohlhaas, Michael, additional, Friedrich, Erik, additional, Bahlmann, Ferdinand, additional, Kappl, Reinhard, additional, Maack, Christoph, additional, Böhm, Michael, additional, and Laufs, Ulrich, additional

Published
2011
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37. Reply

Author

Custodis, Florian, primary, Schirmer, Stephan H., additional, Baumhäkel, Magnus, additional, Heusch, Gerd, additional, Böhm, Michael, additional, and Laufs, Ulrich, additional

Published
2011
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40. Blocking Interferon β Stimulates Vascular Smooth Muscle Cell Proliferation and Arteriogenesis

Author

Schirmer, Stephan H., primary, Bot, Pieter T., additional, Fledderus, Joost O., additional, van der Laan, A.M., additional, Volger, Oscar L., additional, Laufs, Ulrich, additional, Böhm, Michael, additional, de Vries, Carlie J.M., additional, Horrevoets, Anton J.G., additional, Piek, Jan J., additional, Hoefer, Imo E., additional, and van Royen, Niels, additional

Published
2010
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42. Local Cytokine Concentrations and Oxygen Pressure Are Related to Maturation of the Collateral Circulation in Humans

Author

Schirmer, Stephan H., primary, van Royen, Niels, additional, Moerland, Perry D., additional, Fledderus, Joost O., additional, Henriques, José P., additional, van der Schaaf, René J., additional, Vis, Marije M., additional, Baan, Jan, additional, Koch, Karel T., additional, Horrevoets, Anton J.G., additional, Hoefer, Imo E., additional, and Piek, Jan J., additional

Published
2009
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43. Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis

Author

Grundmann, Sebastian, primary, Schirmer, Stephan H., additional, Hekking, Liesbeth H. P., additional, Post, Jan Andries, additional, Ionita, Mihaela G., additional, Groot, Daphne de, additional, Royen, Niels van, additional, Berg, Bernard van den, additional, Vink, Hans, additional, Moser, Martin, additional, Bode, Christoph, additional, Kleijn, Dominique de, additional, Pasterkamp, Gerard, additional, Piek, Jan J., additional, and Hoefer, Imo E., additional

Published
2009
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45. Interferon-β Signaling Is Enhanced in Patients With Insufficient Coronary Collateral Artery Development and Inhibits Arteriogenesis in Mice

Author

Schirmer, Stephan H., primary, Fledderus, Joost O., additional, Bot, Pieter T.G., additional, Moerland, Perry D., additional, Hoefer, Imo E., additional, Baan, Jan, additional, Henriques, José P.S., additional, van der Schaaf, René J., additional, Vis, Marije M., additional, Horrevoets, Anton J.G., additional, Piek, Jan J., additional, and van Royen, Niels, additional

Published
2008
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47. START Trial

Author

van Royen, Niels, primary, Schirmer, Stephan H., additional, Atasever, Bektas, additional, Behrens, Casper Y.H., additional, Ubbink, Dirk, additional, Buschmann, Eva E., additional, Voskuil, Michiel, additional, Bot, Pieter, additional, Hoefer, Imo, additional, Schlingemann, Reinier O., additional, Biemond, Bart J., additional, Tijssen, J.G., additional, Bode, Christoph, additional, Schaper, Wolfgang, additional, Oskam, Jacques, additional, Legemate, Dink A., additional, Piek, Jan J., additional, and Buschmann, Ivo, additional

Published
2005
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48. Design of the START-trial: STimulation of ARTeriogenesis using subcutaneous application of GM-CSF as a new treatment for peripheral vascular disease. A randomized, double-blind, placebo-controlled trial

Author

van Royen, Niels, primary, Piek, Jan J, additional, Legemate, Dink A, additional, Schaper, Wolfgang, additional, Oskam, Jacques, additional, Atasever, Bektas, additional, Voskuil, Michiel, additional, Ubbink, Dirk, additional, Schirmer, Stephan H, additional, Buschmann, Ivo, additional, Bode, Christoph, additional, and Buschmann, Eva E, additional

Published
2003
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49. Expression of a retinoic acid signature in circulatingCD34 cells from coronary artery disease patients.

Author

van der Pouw Kraan, Tineke C. T. M., Schirmer, Stephan H., Fledderus, Joost O., Moerland, Perry D., Baggen, Josefien M., Leyen, Thomas A., van der Laan, Anja M., Piek, Jan J., van Royen, Niels, and Horrevoets, Anton J. G.

Subjects
GENE expression, TRETINOIN, CORONARY disease, CARDIAC patients, GENES
Abstract

Background: Circulating CD34+ progenitor cells have the potential to differentiate into a variety of cells, including endothelial cells. Knowledge is still scarce about the transcriptional programs used by CD34+ cells from peripheral blood, and how these are affected in coronary artery disease (CAD) patients. Results: We performed a whole genome transcriptome analysis of CD34+ cells, CD4+ T cells, CD14+ monocytes, and macrophages from 12 patients with CAD and 11 matched controls. CD34+ cells, compared to other mononuclear cells from the same individuals, showed high levels of KRAB box transcription factors, known to be involved in gene silencing. This correlated with high expression levels in CD34+ cells for the progenitor markers HOXA5 and HOXA9, which are known to control expression of KRAB factor genes. The comparison of expression profiles of CD34+ cells from CAD patients and controls revealed a less naïve phenotype in patients' CD34+ cells, with increased expression of genes from the Mitogen Activated Kinase network and a lowered expression of a panel of histone genes, reaching levels comparable to that in more differentiated circulating cells. Furthermore, we observed a reduced expression of several genes involved in CXCR4-signaling and migration to SDF1/CXCL12. Conclusions: The altered gene expression profile of CD34+ cells in CAD patients was related to activation/ differentiation by a retinoic acid-induced differentiation program. These results suggest that circulating CD34+ cells in CAD patients are programmed by retinoic acid, leading to a reduced capacity to migrate to ischemic tissues. [ABSTRACT FROM AUTHOR]

Published
2010
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50. Differential effects of MCP-1 and leptin on collateral flow and arteriogenesis

Author

Schirmer, Stephan H., Buschmann, Ivo R., Jost, Marco M., Hoefer, Imo E., Grundmann, Sebastian, Andert, Jan-Philip, Ulusans, Susann, Bode, Christoph, Piek, Jan J., and van Royen, Niels

Subjects
*LEPTIN, *HORMONES, *BLOOD vessels, *MUSCLE cells
Abstract

Strategies to therapeutically stimulate collateral artery growth in experimental models have been studied intensively in the last decades. However, the experimental methods to detect collateral artery growth are discussed controversially and vary significantly. We compared different methods in a model of arteriogenesis in the rabbit hind limb and determined the effects on collateral flow of a known pro-arteriogenic factor, monocyte chemoattractant protein-1 (MCP-1), and a cytokine not previously evaluated for its arteriogenic efficacy, the adipocytokine leptin.Forty-two New Zealand White rabbits received either MCP-1, leptin or PBS after ligation of the right femoral artery. The pro-arteriogenic effect of MCP-1 was confirmed by flow measurements during reactive hyperemia, as demonstrated by increased flow ratio (PBS 0.56±0.07 vs. MCP-1 0.77±0.06, no unit, p<0.0001), ankle-brachial index and microsphere-based conductance measurements (PBS 50.8±2.1 vs. MCP-1 225.8±8.8 ml/min/100 mm Hg, p<0.001). Biological activity of leptin on rabbit monocytes was shown by a dose dependent increase in Mac-1 expression. In-vivo administration of leptin also led to an increase in hyperemic flow and flow ratio (leptin 0.69±0.03, p<0.05 vs. PBS), but not to an increase in collateral conductance (leptin 54.7±4.1 ml/min/100 mm Hg, p=ns vs. PBS) or proliferation of vascular smooth muscle cells (Ki-67 staining: PBS 24.7±3.9%, leptin 22.7%±0.8% (p=ns), MCP-1 32.0±1.9% (p<0.01)). Ki-67 mRNA measured by real-time polymerase chain reaction increased (8.8±3.1-fold, p<0.01) during natural arteriogenesis, and was further enhanced (25.5±8.1-fold, p<0.005) after stimulation with MCP-1.MCP-1 and leptin increase collateral flow in the rabbit hind limb model. In contrast to MCP-1, leptin does not enhance direct markers of vascular proliferation such as collateral conductance under maximal vasodilation and proliferation indices. The observed increase in hyperemic collateral flow thus most probably can be attributed to the well-documented vasodilatory effects of leptin. These data stress the necessity of the use of proliferation markers and microsphere-based conductance measurements under maximal vasodilation in order to separate effects of substances on vascular proliferation from effects on vasodilation. [Copyright &y& Elsevier]

Published
2004
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