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2. Systemic, Mucosal Immune Activation and Psycho-Sexual Health in ART-Suppressed Women Living with HIV: Evaluating Biomarkers and Environmental Stimuli

Author

Nijhawan, Parni, primary, Carraro, Anna, additional, Vita, Serena, additional, Del Borgo, Cosmo, additional, Tortellini, Eeva, additional, Guardiani, Mariasilvia, additional, Zingaropoli, Maria Antonella, additional, Mengoni, Fabio, additional, Petrozza, Vincenzo, additional, Di Troia, Luciana, additional, Marcucci, Immacolata, additional, Kertusha, Blerta, additional, Scerpa, Maria Cristina, additional, Turriziani, Ombretta, additional, Vullo, Vincenzo, additional, Ciardi, Maria Rosa, additional, Mastroianni, Claudio Maria, additional, Marocco, Raffaella, additional, and Lichtner, Miriam, additional

Published
2023
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3. Consensus for Flow Cytometry Clinical Report on Multiple Myeloma: A Multicenter Harmonization Process Merging Laboratory Experience and Clinical Needs

Author

Cordone, Iole, primary, Amodeo, Rachele, additional, Bellesi, Silvia, additional, Bottan, Fiorella, additional, Buccisano, Francesco, additional, De Propris, Maria Stefania, additional, Masi, Serena, additional, Panichi, Valentina, additional, Scerpa, Maria Cristina, additional, Annibali, Ombretta, additional, Bongarzoni, Velia, additional, Caravita di Toritto, Tommaso, additional, Coppetelli, Ugo, additional, Cupelli, Luca, additional, de Fabritiis, Paolo, additional, Franceschini, Luca, additional, Garzia, Mariagrazia, additional, Fiorini, Alessia, additional, Laverde, Giacinto, additional, Mengarelli, Andrea, additional, Za, Tommaso, additional, and Petrucci, Maria Teresa, additional

Published
2023
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5. Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for “vertical” and “lateral” combination strategies

Author

Ricciardi, Maria Rosaria, Scerpa, Maria Cristina, Bergamo, Paola, Ciuffreda, Ludovica, Petrucci, Maria Teresa, Chiaretti, Sabina, Tavolaro, Simona, Mascolo, Maria Grazia, Abrams, Stephen L., Steelman, Linda S., Tsao, Twee, Marchetti, Antonio, Konopleva, Marina, Del Bufalo, Donatella, Cognetti, Francesco, Foà, Robin, Andreeff, Michael, McCubrey, James A., Tafuri, Agostino, and Milella, Michele

Published
2012
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6. Genetic lesions disrupting calreticulin 3′‐untranslated region in JAK2 mutation‐negative polycythemia vera

Author

Quattrocchi, Alberto, primary, Maiorca, Carlo, additional, Billi, Monia, additional, Tomassini, Simona, additional, De Marinis, Elisabetta, additional, Cenfra, Natalia, additional, Equitani, Francesco, additional, Gentile, Martina, additional, Ceccherelli, Alessia, additional, Banella, Cristina, additional, Mecarocci, Sergio, additional, Scerpa, Maria Cristina, additional, Pisanò, Stefania, additional, Pacilli, Annalisa, additional, Di Cristofano, Claudio, additional, Mancini, Massimiliano, additional, Guglielmelli, Paola, additional, Vannucchi, Alessandro Maria, additional, Noguera, Nelida, additional, Grignani, Francesco, additional, Cimino, Giuseppe, additional, and Nervi, Clara, additional

Published
2020
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7. Overview of T-cell depletion in haploidentical stem cell transplantation

Author

Daniele, Nicola, Scerpa, Maria Cristina, Caniglia, Maurizio, Ciammetti, Chiara, Rossi, Cecilia, Bernardo, Maria Ester, Locatelli, Franco, Isacchi, Giancarlo, Zinno, Francesco, Locatelli, Franco (ORCID:0000-0002-7976-3654), Daniele, Nicola, Scerpa, Maria Cristina, Caniglia, Maurizio, Ciammetti, Chiara, Rossi, Cecilia, Bernardo, Maria Ester, Locatelli, Franco, Isacchi, Giancarlo, Zinno, Francesco, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

N/A

Published
2012

8. Processing of hematopoietic stem cells from peripheral blood before cryopreservation: use of a closed automated system

Author

Zinno, Francesco, Landi, Fabiola, Scerpa, Maria Cristina, Aureli, Viviana, Lanti, Alessandro, Ceccarelli, Stefano, Caniglia, Maurizio, Miele, Massimino Jan, Daniele, Nicola, Landolfo, Attilio, Cometa, Angela Maria, Locatelli, Franco, Isacchi, Giancarlo, Locatelli, Franco (ORCID:0000-0002-7976-3654), Zinno, Francesco, Landi, Fabiola, Scerpa, Maria Cristina, Aureli, Viviana, Lanti, Alessandro, Ceccarelli, Stefano, Caniglia, Maurizio, Miele, Massimino Jan, Daniele, Nicola, Landolfo, Attilio, Cometa, Angela Maria, Locatelli, Franco, Isacchi, Giancarlo, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

BACKGROUND: Hematopoietic stem cell transplantation is commonly used to treat several oncohematologic diseases. The autologous hematopoietic progenitor cells collected through apheresis (HPC-A) must be cryopreserved and stored before use in vivo. Cell processing that precedes cryopreservation of HPC-A includes volume reduction aimed at reducing the amount of dimethyl sulfoxide used, as well as storage space.STUDY DESIGN AND METHODS: The aim of our study was to assess the effectiveness of volume reduction performed with an automated closed system, namely, the Sepax S100 cell separation device (Biosafe SA). A total of 165 procedures were carried out on concentrates collected from 104 adult and pediatric patients. As a control group, 30 HPC-A units processed according to the standard method (i.e., centrifugation at a speed of 850 x g for 10 minutes, followed by manual plasma reduction) were evaluated.RESULTS: The volume reduction obtained was 59% (range, 20.54%-84.21%; standard deviation [SD], +/- 12.19%), going from 236 mL (range, 100-443 mL; SD, +/- 80.41 mL) to 97 mL (range, 33.00-263.00 mL; SD, +/- 47.41 mL); recovery of nucleated cells was 90% (range, 64.84%-105.93%; SD, +/- 8.76%), while that of CD34+ cells was 91% (range, 59.30%-119.37%; SD, +/- 13.30%). These values did not differ from those obtained using the standard method. Automated processing required 20 minutes versus 40 minutes of manual processing.DISCUSSION: Our data demonstrate that volume reduction carried out with the Sepax S100 automated system was particularly effective; cell recovery was excellent and the time spent was short.' Moreover, the closed system allows cell processing to be carried out in a contamination-controlled environment, in accordance with good manufacturing practice guidelines.

Published
2011

9. T(reg) cells: collection, processing, storage and clinical use

Author

Daniele, Nicola, Scerpa, Maria Cristina, Landi, Fabiola, Caniglia, Maurizio, Miele, Massimino Jan, Locatelli, Franco, Isacchi, Giancarlo, Zinno, Francesco, Locatelli, Franco (ORCID:0000-0002-7976-3654), Daniele, Nicola, Scerpa, Maria Cristina, Landi, Fabiola, Caniglia, Maurizio, Miele, Massimino Jan, Locatelli, Franco, Isacchi, Giancarlo, Zinno, Francesco, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

T regulatory cells are fundamental in the maintenance of immune homeostasis and self-tolerance. Experimental models suggest the existence of two functional types of T-reg cells designated naturally occurring and induced. Interest in T-reg cells increased with evidence from experimental mouse and human models demonstrating that the immunosuppressive potential of these cells can be utilized in the treatment of various pathological conditions. The existence of a subpopulation of suppressive T cells was the subject of significant controversy among immunologists for many years. T regulatory cells limit immune activation through a variety of direct and indirect interactions, many of which are yet to be determined. Fully understanding T-reg cells biology will lead us to harnessing the capacity of these cells in order to develop strategies to prevent autoimmune disorders and tolerance to transplantation. Efficient isolation, expansion and cryopreservation strategies that comply with Good Manufacturing Practice (GMP) guidelines are prerequisites for the clinical application of human CD4+ CD25+ CD127(low) FOXP3+ regulatory T cells. (C) 2011 Elsevier GmbH. All rights reserved.

Published
2011

10. Multiple Strategies Based on MEK, mTOR and BCL-2 Signal Transduction Inhibition in Acute Lymphoblastic Leukemia (ALL)

Author

Ricciardi, Maria Rosaria, primary, Decandia, Samantha, primary, Santinelli, Sara, primary, Gregorj, Chiara, primary, De Cave, Fabiana, primary, Scerpa, Maria Cristina, primary, Bergamo, Paola, primary, Libotte, Francesco, primary, De Benedictis, Cinzia, primary, Vitale, Antonella, primary, Petrucci, Maria Teresa, primary, Konopleva, Marina, primary, Andreeff, Michael, primary, Milella, Michele, primary, Foa, Robert, primary, and Tafuri, Agostino, primary

Published
2008
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11. Development of Mek inhibition (MEK-I)-Based Therapeutic Strategies in Acute Myeloid Leukemia (AML)

Author

Milella, Michele, primary, Ricciardi, Maria Rosaria, additional, Bergamo, Paola, additional, Scerpa, Maria Cristina, additional, Gervasoni, Jacopo, additional, Petrucci, Maria Teresa, additional, Chiaretti, Sabina, additional, Tavolaro, Simona, additional, Ciuffreda, Ludovica, additional, Decandia, Samantha, additional, Libotte, Francesco, additional, Abrams, Stephen Lee, additional, Steelman, Linda S, additional, Konopleva, Marina, additional, Cognetti, Francesco, additional, Foa, Robert, additional, Andreeff, Michael, additional, McCubrey, James, additional, and Tafuri, Agostino, additional

Published
2008
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