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In this work, new substituted benzimidazolium salts 2a–d having different groups on the side chain have been synthesized and reacted with Ag2O to produce Ag(I) N-heterocyclic carbene (NHC) complexes 3a–d. Ag(I)-NHC complexes were used as a carben transfer agents to synthesize ruthenium(II)-NHC complexes 4a–d. The structures of all compounds were characterized by 1H NMR, 13C NMR and FT-IR spectroscopies and elemental analysis. The IC50 values of these complexes were determined by MTT assay against MCF7, MDA-MB-231 and HF cancer cell lines. The lowest MIC values were obtained for two complexes, 4b and 4d. The Ru(II)-NHC complexes generally triggered stronger bacterial growth inhibition than the metal-free benzimidazolium cations. Enzymatic inhibition investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE) showed that 4b and 4d are the most potent inhibitors against AchE with an IC50 of 2.52 and 5.06 µg mL−1, respectively, and against TyrE with an IC50 of 19.88 and 24.95 µg mL−1, respectively. Antioxidant activity of the synthesized NHC ligands 2a–2d and their respective Ru(II)-NHC complexes 4a–4d was assessed by three different techniques: the 2.2-diphenyl-1-picrylhydrazyl (DPPH), the 2.2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals scavenging and the β-carotene linoleic acid bleaching assay, showing that 4d has recorded an important antioxidant activity.

International audience; Coordination compounds Pd(L1)Cl2, Pd(L2)Cl2, and Pd(L3)Cl2 have been synthesized fromoptically pure α-amino-oxime ligands L1–L3 based on (R)-limonene. Structures of the new palladiumcomplexes are characterized and described by NMR spectroscopy and X-rays. These α-amino-oximeligands were then evaluated in the palladium-catalysed allylation of 1,3-dioxo compounds.; Les complexes Pd(L1)Cl2, Pd(L2)Cl2, et Pd(L3)Cl2 ont été synthétisés à partir des ligands α-amino-oxime L1-L3 issus du (R)-limonene. Ces nouveaux complexes de palladium ont été carracté-risés par RMN et diffraction aux rayons X. Les ligands α-amino-oxime associés à des précurseurs depalladium ont été évalués sur des réactions d’alkylation allylique.

The aim of this study was a detailed examination of the synthesis of 3-methyleneisoindolinones comprising various functional groups. Methylmagnesuim bromide and PTSA was employed for the synthesis of these compounds. A wide range of 3-methyleneisoindolinones were afforded in good to excellent yields. On the other hand, 3-methyleneisoindolinones was also obtained by an efficient microwave method. The frame work of these derivatives was constructed from 2- acetylbenzoic acid and various primary amines via two-component reaction. The obtained compounds were characterized by 1H NMR, 13C-NMR and IR and elemental analysis.

International audience; N,N-Substituted benzimidazole salts were successfully synthesized and characterized by 1H-NMR, 13C {1H} NMR and IR techniques, which support the proposed structures. Catalysts generated in situ were efficiently used for the carbonylative cross-coupling reaction of 2 bromopyridine with various boronic acids. The reaction was carried out in THF at 110 °C in the presence of K2CO3 under inert conditions and yields unsymmetrical arylpyridine ketones. All N,N-substituted benzimidazole salts 2a–i and 4a–i studied in this work were screened for their cytotoxic activities against human cancer cell lines such us MDA-MB-231, MCF-7 and T47D. The N,N-substituted benzimidazoles 2e and 2f exhibited the most cytotoxic effect with promising cytotoxic activity with IC50 values of 4.45 μg mL−1 against MDA-MB-231 and 4.85 μg mL−1 against MCF7 respectively.

[This corrects the article DOI: 10.1039/C8RA08897G.]., (This journal is © The Royal Society of Chemistry.)