1. Impact of age on treatment response in men with prostate cancer treated with radiotherapy
- Author
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Bryant, Alex K, Nelson, Tyler J, McKay, Rana R, Kader, A Karim, Parsons, J Kellogg, Einck, John P, Kane, Christopher J, Sandhu, Ajay P, Mundt, Arno J, Murphy, James D, and Rose, Brent S
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Urologic Diseases ,Aging ,Cancer ,Prostate Cancer ,Clinical Research ,Good Health and Well Being ,hormone receptor agonists ,neoadjuvant therapy ,prostatic neoplasm ,radiotherapy ,veterans ,Clinical sciences - Abstract
ObjectiveTo analyse the effect of age at diagnosis on clinical outcomes of localized prostate cancer (PCa) treated with radiation therapy.Subjects and methodsWe identified 12 784 patients with intermediate- or high-risk localized PCa treated with radiation therapy (RT) and neoadjuvant androgen deprivation therapy (ADT) between 2000 and 2015 from nationwide Veterans Affairs data. Patients were grouped into three age categories (≤59, 60-69, and ≥70 years old). Outcomes included immediate PSA response (3-month post-RT PSA and 2-year PSA nadir, grouped into
- Published
- 2022