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1. Simultaneous navigation and mascon gravity estimation around small bodies

Author

Sanchez, Julio C. and Schaub, Hanspeter

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Space Physics
Abstract

This manuscript develops a simultaneous navigation and gravity estimation strategy around a small body. The scheme combines dynamical model compensation with a mascon gravity fit. Dynamical compensation adds the unmodeled acceleration to the filter state. Consequently, the navigation filter is able to generate an on-orbit position-unmodeled acceleration dataset. The available measurements correspond to the landmarks-based navigation technique. Accordingly, an on-board camera is able to provide landmark pixels. The aforementioned position-unmodeled acceleration dataset serves to train a mascon gravity model on-board while in flight. The training algorithm finds the optimal mass values and locations using Adam gradient descent. By a careful choice of the mascon variables and constraints projection, the masses are ensured to be positive and within the small body shape. The numerical results provide a comprehensive analysis on the global gravity accuracy for different estimation scenarios.

Published
2023

6. Manoeuvre detection in Low Earth Orbit with Radar Data

Author

Montilla, Jose M., Sanchez, Julio C., Vazquez, Rafael, Galan-Vioque, Jorge, Benayas, Javier Rey, and Siminski, Jan

Subjects
Mathematics - Optimization and Control, Electrical Engineering and Systems Science - Systems and Control, Mathematics - Probability, Statistics - Applications, 70M20
Abstract

This work outlines and assesses several methods for the detection of manoeuvres in Low Earth Orbit (LEO) from surveillance radar data. To be able to detect manoeuvres, the main starting assumption is that the object under analysis has an orbit known with a sufficient degree of precision. Based on the precise (a posteriori) orbit and radar data, several manoeuvre detection methods are presented; one is based on unscented Kalman filtering, whereas two others algorithms are based on reachability analysis of the state, which correlates its prediction set with the next track from the radar. The filtering algorithm can be extended for several radar tracks, whereas the reachability-based methods are more precise in detecting manoeuvres. Then, to inherit the best properties of both classes of algorithms, a manoeuvre detection filter that combines both concepts is finally presented. Manoeuvre detection results are presented first for simulated scenarios -- for validation and calibration purposes -- and later for real data. Radar information comes from the Spanish Space Surveillance Radar (S3TSR), with real manoeuvre information and high-quality ephemerides. The results show promise, taking into account that a single surveillance radar is the only source of data, obtaining manoeuvre detection rates of more than 50% and false positive rates of less than 10%., Comment: Preprint submitted to Advances in Space Research

Published
2022

8. Adventures in Multi-Omics I: Combining heterogeneous data sets via relationships matrices

Author

Akdemir, Deniz and Sanchez, Julio Isidro

Subjects
Statistics - Applications, Mathematics - Statistics Theory, Quantitative Biology - Genomics, Statistics - Methodology
Abstract

In this article, we propose a covariance based method for combining partial data sets in the genotype to phenotype spectrum. In particular, an expectation-maximization algorithm that can be used to combine partially overlapping relationship/covariance matrices is introduced. Combining data this way, based on relationship matrices, can be contrasted with a feature imputation based approach. We used several public genomic data sets to explore the accuracy of combining genomic relationship matrices. We have also used the heterogeneous genotype/phenotype data sets in the https://triticeaetoolbox.org/ to illustrate how this new method can be used in genomic prediction, phenomics, and graphical modeling., Comment: This project was supported by WheatSustain

Published
2019

15. Efficient Breeding by Genomic Mating

Author

Akdemir, Deniz and Sanchez, Julio Isidro

Subjects
Quantitative Biology - Populations and Evolution
Abstract

In this article, we propose an approach to breeding which focuses on mating instead of truncation selection, our method uses genome-wide marker information in a similar fashion to genomic selection so we refer it to as genomic mating. Using concepts of estimated breeding values, risk (usefulness) and inbreeding, an efficient mating approach is formulated for improvement of breeding values in the long run. We have used a genetic algorithm to find solutions to this optimization problem. Results from our simulations point to the efficiency of genomic mating for breeding complex traits compared to truncation selection.

Published
2016

17. Sparse testing designs for optimizing predictive ability in sugarcane populations.

Author

Garcia-Abadillo, Julian, Adunola, Paul, Silva Aguilar, Fernando, Trujillo-Montenegro, Jhon Henry, Jaime Riascos, John, Persa, Reyna, Isidro y Sanchez, Julio, and Jarquín, Diego

Subjects
SUGAR crops, SUCROSE, PREDICTION models, GENOTYPES, PHENOTYPES
Abstract

Sugarcane is a crucial crop for sugar and bioenergy production. Saccharose content and total weight are the two main key commercial traits that compose sugarcane's yield. These traits are under complex genetic control and their response patterns are influenced by the genotype-by-environment (G×E) interaction. An efficient breeding of sugarcane demands an accurate assessment of the genotype stability through multi-environment trials (METs), where genotypes are tested/evaluated across different environments. However, phenotyping all genotype-in-environment combinations is often impractical due to cost and limited availability of propagation-materials. This study introduces the sparse testing designs as a viable alternative, leveraging genomic information to predict unobserved combinations through genomic prediction models. This approach was applied to a dataset comprising 186 genotypes across six environments (6×186=1,116 phenotypes). Our study employed three predictive models, including environment, genotype, and genomic markers as main effects, as well as the G×E to predict saccharose accumulation (SA) and tons of cane per hectare (TCH). Calibration sets sizes varying between 72 (6.5%) to 186 (16.7%) of the total number of phenotypes were composed to predict the remaining 930 (83.3%). Additionally, we explored the optimal number of common genotypes across environments for G×E pattern prediction. Results demonstrate that maximum accuracy for SA (ρ=0:611) and for TCH (ρ=0:341) was achieved using in training sets few (3) to no common (0) genotype across environments maximizing the number of different genotypes that were tested only once. Significantly, we show that reducing phenotypic records for model calibration has minimal impact on predictive ability, with sets of 12 non-overlapped genotypes per environment (72=12×6) being the most convenient costbenefit combination. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Logistic Biplots for Ordinal Data with an Application to Job Satisfaction of Doctorate Degree Holders in Spain

Author

Vicente-Villardón, José Luis and Sánchez, Julio César Hernández

Subjects
Statistics - Applications, Statistics - Computation, Statistics - Methodology, 62H, 62P
Abstract

Biplot Methods allow for the simultaneous representation of individuals and variables of a data matrix. For Binary or Nominal data, Logistic biplots have been recently developed to extend the classical linear representations for continuous data. When data are ordinal, linear, binary or nominal logistic biplots are not adequate and techniques as Categorical Principal Component Analysis (CATPCA) or Item Response Theory (IRT) for ordinal items should be used instead. In this paper we extend the Biplot to ordinal data. The resulting method is termed Ordinal Logistic Biplot (OLB). Row scores are computed to have ordinal logistic responses along the dimensions and column parameters produce logistic response surfaces that, projected onto the space spanned by the row scores, define a linear biplot. A proportional odds model is used, obtaining a multidimensional model known as graded response model in the Item Response Theory literature. We study the geometry of such a representation and construct computational algorithms for the estimation of parameters and the calculation of prediction directions. Ordinal Logistic Biplots extend both CATPCA and IRT in the sense that gives a graphical representation for IRT similar to the biplot for CATPCA. The main theoretical results are applied to the study of job satisfaction of doctorate (PhD) holders in Spain. Holders of doctorate degrees or other research qualifications are crucial to the creation, commercialization and dissemination of knowledge and to innovation. The proposed methods are used to extract useful information from the Spanish data from the international 'Survey on the careers of doctorate holders (CDH)', jointly carried out Eurostat, the Organisation for Economic Co-operation and Development (OECD) and UNESCO's Institute for Statistics (UIS)., Comment: 26 pages, 11 figures,2 tables. arXiv admin note: text overlap with arXiv:1309.5486

Published
2014

22. Logistic biplot for nominal data

Author

Sánchez, Julio César Hernández and Vicente-Villardón, José Luis

Subjects
Statistics - Methodology
Abstract

Classical Biplot Methods allow for the simultaneous representation of individuals (rows) and variables (columns) of a data matrix. For Binary data, Logistic biplots have been recently developed.When data are nominal, linear or even binary logistic biplots are not adequate and techniques as Multiple Correspondence Analysis (MCA), Latent Trait Analysis (LTA) or Item Response Theory for nominal items should be used instead. In this paper we extend the binary logistic biplot to nominal data. The resulting method is termed Nominal Logistic Biplot, although the variables are represented as convex prediction regions rather than vectors. Using the methods from Computational Geometry, the set of prediction regions is converted to a set of points in such a way that the prediction for each individual is established by its closest category point. Then interpretation is based on distances rather than on projections. We study the geometry of such a representation and construct computational algorithms for the estimation of parameters and the calculation of prediction regions. Nominal Logistic Biplots extend both MCA and LTA in the sense that gives a graphical representation for LTA similar to the one obtained in MCA., Comment: 22 pages, 8 figures

Published
2013

29. Acceptability of the vaccine against human papilloma virus in adults

Author

Clavijo Naula, Joseline Andrea, Benalcazar Quinche, Juan Carlos, Ojeda Sanchez, Julio Cesar, Charry Ramirez, José Ricardo, Clavijo Naula, Joseline Andrea, Benalcazar Quinche, Juan Carlos, Ojeda Sanchez, Julio Cesar, and Charry Ramirez, José Ricardo

Abstract

Human papillomavirus (HPV) is responsible for 80% of cases of cervical cancer (CCU), worldwide it is placed in the fourth place of the most common cancers, this disease is preventable through the application of the vaccine, however, this vaccine has low acceptance compared to other vaccines (tetanus, diphtheria, etc). The vaccine is applied to girls who range the ages of 9 and 12, in two doses with an interval of 6 months between each dose, for this reason parents are the ones who play a very important role in accepting the vaccine. According to the results of several researches, the acceptability of the vaccine is good, nevertheless, there may be numerous barriers that prevent vaccination, such as: lack of knowledge about human papilloma virus and the vaccine, the male gender, since they consider that they are not at risk, myths about the adverse effects of the vaccine and in certain regions the cost of the vaccine all lead to reduced acceptability of human papillomavirus vaccine. In this way, it is believed that in order to give a higher acceptability of the vaccine, it is necessary to educate the general population since it will help in decision-making and in this way, higher vaccination rates would be ensured. Keywords: Patient Acceptance of Health Care, Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18., El virus del papiloma humano (VPH) es responsable del 80% de casos de cáncer cervicouterino (CCU), a nivel mundial ocupa el cuarto lugar de los cánceres más comunes, esta enfermedad es prevenible mediante la aplicación de la vacuna, sin embargo, esta vacuna tiene baja aceptación comparadas con otras vacunas (tétanos, difteria, etc). La vacuna es aplicada en niñas entre 9 a 12 años, en dos dosis con un intervalo de 6 meses entre cada dosis, por tal motivo los padres son quienes toman un papel muy importante en la aceptación de la vacuna. De acuerdo a los resultados de varias investigaciones la aceptabilidad de la vacuna es buena, sin embargo, pueden presentarse numerosas barreras que impiden la vacunación como: la falta de conocimiento sobre el virus de papiloma humano y la vacuna, el género masculino ya que consideran no estar en riesgo, los mitos sobre los efectos adversos de la vacuna y en ciertas regiones el costo de la vacuna todo esto llevando a reducir la aceptabilidad de la vacuna contra el virus de papiloma humano. De esta manera, se cree que para que la aceptabilidad de la vacuna sea superior es necesario educar a la población en general ya que ayudara en la toma de decisiones y de esta manera se asegurarían tasas superiores de vacunación. Palabras clave: Aceptación de la Atención de Salud, Vacuna Tetravalente Recombinante contra el Virus del Papiloma Humano Tipos 6, 11, 16, 18.

Published
2023

30. Protective role of physical activity patterns prior to COVID-19 confinement with the severity/duration of respiratory pathologies consistent with COVID-19 symptoms in Spanish populations

Author

Latorre-Román, Pedro Ángel, Guzmán-Guzmán, Iris Paola, Delgado-Floody, Pedro, Herrador Sanchez, Julio, Aragón-Vela, Jerónimo, García Pinillos, Felipe, Párraga Montilla, Juan A., Latorre-Román, Pedro Ángel, Guzmán-Guzmán, Iris Paola, Delgado-Floody, Pedro, Herrador Sanchez, Julio, Aragón-Vela, Jerónimo, García Pinillos, Felipe, and Párraga Montilla, Juan A.

Abstract

The main purpose of the present study was to determine the association of physical activity (PA) patterns prior to COVID-19 confinement with severe respiratory distress consistent with COVID-19 symptoms. Participants were recruited by sending a survey through various social network channels via the snowball method. A voluntary sample of 420 individuals consisting of 199 men and 221 women from the Spanish national territory participated in this study. Some factors, such as being overweight and obese were related to the presence of a greater number of symptoms associated with COVID-19. Interestingly, it was observed that not performing moderate or vigorous PA increased the risk of COVID-19 symptoms. Consequently, when the effect of the practise of PA was evaluated in terms of the number of practises per week and in minutes per practise per week, a protective effect was observed, where moderate PA >150 min per week reported an inverse association with hospitalization for respiratory symptoms (RR: 95%CI: 0.24, 0.05–1.04, P = 0.05). Likewise, overweight (RR: 16.3, 95%CI: 1.93–137.9, P = 0.01), obesity (RR: 19.1, 95%CI: 1.63–222.5, P = 0.019) and non-performance of moderate PA (RR: 4.12, 95%CI; 0.95–17.76, P = 0.05) reported positive associations with hospitalization for respiratory symptoms. Thus, the practise of moderate PA (>150 min per week) is a protective factor against hospitalization for respiratory symptoms consistent with COVID-19 symptoms., The main purpose of the present study was to determine the association of physical activity (PA) patterns prior to COVID-19 confinement with severe respiratory distress consistent with COVID-19 symptoms. Participants were recruited by sending a survey through various social network channels via the snowball method. A voluntary sample of 420 individuals consisting of 199 men and 221 women from the Spanish national territory participated in this study. Some factors, such as being overweight and obese were related to the presence of a greater number of symptoms associated with COVID-19. Interestingly, it was observed that not performing moderate or vigorous PA increased the risk of COVID-19 symptoms. Consequently, when the effect of the practise of PA was evaluated in terms of the number of practises per week and in minutes per practise per week, a protective effect was observed, where moderate PA >150 min per week reported an inverse association with hospitalization for respiratory symptoms (RR: 95%CI: 0.24, 0.05–1.04, P = 0.05). Likewise, overweight (RR: 16.3, 95%CI: 1.93–137.9, P = 0.01), obesity (RR: 19.1, 95%CI: 1.63–222.5, P = 0.019) and non-performance of moderate PA (RR: 4.12, 95%CI; 0.95–17.76, P = 0.05) reported positive associations with hospitalization for respiratory symptoms. Thus, the practise of moderate PA (>150 min per week) is a protective factor against hospitalization for respiratory symptoms consistent with COVID-19 symptoms.

Published
2023

35. Effects of polycyclic aromatic hydrocarbons on gestational hormone production in a placental cell line: Application of passive dosing to in vitro tests

Author

Valderrama, Jhon Fredy Narváez, primary, Gil, Vanessa Correa, additional, Alzate B, Viviana, additional, Tavera, Edison Andrés, additional, Noreña, Edgar, additional, Porras, Jazmín, additional, Quintana-Castillo, Juan Carlos, additional, García L, Juan José, additional, Molina P, Francisco José, additional, Ramos-Contreras, Carlos, additional, and Sanchez, Julio Bueno, additional

Published
2022
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40. A multicategory logit model detecting temporal changes in antimicrobial resistance

Author

AERTS, Marc, Teng, Kendy Tzu-yun, JASPERS, Stijn, Alvarez Sanchez, Julio, Chindelevitch, Leonid, Teng, Kendy/0000-0003-3200-1545, AERTS, Marc, Teng, Kendy Tzu-yun, JASPERS, Stijn, Alvarez Sanchez, Julio, and Chindelevitch, Leonid

Subjects
Multidisciplinary, Logistic Models, Drug Resistance, Bacterial, Animals, Humans, Microbial Sensitivity Tests, Anti-Bacterial Agents, Group Processes
Abstract

Monitoring and investigating temporal trends in antimicrobial data is a high priority for human and animal health authorities. Timely detection of temporal changes in antimicrobial resistance (AMR) can rely not only on monitoring and analyzing the proportion of resistant isolates based on the use of a clinical or epidemiological cut-off value, but also on more subtle changes and trends in the full distribution of minimum inhibitory concentration (MIC) values. The nature of the MIC distribution is categorical and ordinal (discrete). In this contribution, we developed a particular family of multicategory logit models for estimating and modelling MIC distributions over time. It allows the detection of a multitude of temporal trends in the full discrete distribution, without any assumption on the underlying continuous distribution for the MIC values. The experimental ranges of the serial dilution experiments may vary across laboratories and over time. The proposed categorical model allows to estimate the MIC distribution over the maximal range of the observed experiments, and allows the observed ranges to vary across labs and over time. The use and performance of the model is illustrated with two datasets on AMR in Salmonella. The authors thank the official veterinary services from the Spanish Ministry of Agriculture, Fisheries and Food for providing the CIPR data. The authors also thank the editors and reviewers for their constructive comments.

Published
2021

41. Secure smart contract data sharing for IoT devices

Author

Vega Sanchez, Julio (author) and Vega Sanchez, Julio (author)

Abstract

The increasing demand for sharing Internet of Things (IoT) increases demand for a secure way of sharing data. Smart contracts could provide this because of its distributed nature. Proxy re-encryption is an encryption (PRE) method that can be used to share information. In this paper, a secure data sharing scheme is presented that uses multi-hop PRE with HyperLedger Fabric (HF). The scheme requires only two parties to participate with the data owner serving as the proxy and lets users remain access after re-encrypting the cipher. The implementation is used as means for demonstration and analysis. It still requires further work for actual deployment but demonstrates that the scheme holds in terms of efficiency and scalability., CSE3000 Research Project, Computer Science and Engineering

Published
2022

42. Injerto Autólogo de Calcar Femoral como Contrafuerte para Artroplastía en Fracturas Laterales de Cadera: injerto autologo de calcar femoral en fractura de cadera

Author

Peredo Lazarte, Andres, Ruilova Sanchez, Julio Cesar, Peredo Lazarte, Andres, and Ruilova Sanchez, Julio Cesar

Abstract

Hip fractures represent an important cause of morbimortality in the adult population, more than 50% correspond to lateral fractures, and these include unstable fractures that are difficult to manage. Objective: to analyze the clinical and radiological results of patients treated with partial hip arthroplasty for transtrochanteric fractures, using autologous femoral calcar graft. Methods: prospective study with a quantitative approach. The sample consisted of 11 patients with transtrochanteric hip fracture, who underwent arthroplasty using a femoral calcar graft, with a follow-up of 4 to 6 months, at the Hospital Obrero N°2 of Cochabamba. Clinical and radiological characteristics were analyzed and a description of the surgical technique was made. Results: the average age of the study population was 83.4 years, with 63.6% female (7 patients) and 36.4% male (4 patients). According to the AO classification for lateral hip fractures, type 31A2.2 was the main one with 45.5%. More than 50% of the patients had good stability according to the Gruen zones. More than 60% evolved between good and excellent, according to the Harris scale, with an average of 83.65 (range from 67.1 to 90.8) at the third month and an average of 84.74 at the sixth month. Conclusions: we believe that the treatment of lateral hip fractures using this technique can be an alternative for the management of patients with unstable fractures, with a high probability of osteosynthesis failure and mainly when the patient and relatives agree with the procedure., Las fracturas de cadera representan una causa importante de morbimortalidad en la población adulta, más del 50% corresponden a fracturas laterales, y entre ellas están las inestables que son de difícil manejo. Objetivo: analizar los resultados clínico-radiológicos de pacientes tratados con artroplastía parcial de cadera por fracturas transtrocantericas, utilizando injerto autólogo de calcar femoral. Métodos: el estudio prospectivo de enfoque cuantitativo. La muestra fue de 11 pacientes con fractura transtrocanterica de cadera, en quienes se realizó artroplastía utilizando un injerto de calcar femoral, con un seguimiento entre 4 a 6 meses, en el Hospital Obrero N°2 de Cochabamba. Se analizaron características clínicas, radiológicas y se realiza una descripción de la técnica quirúrgica. Resultados: la edad promedio de la población de estudio fue de 83,4 años, siendo el sexo femenino el 63,6% (7 pacientes) y el sexo masculino 36,4% (4 pacientes). Según la clasificación de la AO para fracturas laterales de cadera, el tipo 31A2.2 fue el principal con 45,5%. Mas del 50% tenían buena estabilidad según las zonas de Gruen. Mas del 60% evolucionaron entre bueno y excelente, según la escala de Harris, con un promedio de 83,65 (rango de 67,1 a 90,8) al tercer mes y un promedio de 84,74 al sexto mes. Conclusiones: el tratamiento de las fracturas laterales de cadera mediante esta técnica, creemos que puede ser una alternativa para el manejo de pacientes con fractura inestable, con altas probabilidades de falla de osteosíntesis y principalmente cuando el paciente y familiares estén de acuerdo con el procedimiento.

Published
2022

45. Implicancia de la transformación digital en la gestión empresarial de la micro y pequeña empresa, sector restaurantes Arequipa 2021

Author

Delgadillo Sanchez, Julio Cesar and Salinas Gainza, Freddy Raúl

Subjects
transformación, Implicancia, purl.org/pe-repo/ocde/ford#2.11.04 [https], restaurantes, digital, gestión, administración y productividad, empresarial
Abstract

El objetivo de esta investigación fue; Determinar la Implicancia de la transformación digital en la Gestión Empresarial de la Micro y Pequeña empresa en el sector restaurantes Arequipa 2021. En el presente trabajo de investigación fue el método científico cuantitativo, de tipo explicativa, diseño de investigación es no experimental – transversal; la población fue un total 147 MYPES, la muestra fue la no probabilística de un 136 MYPES, la técnica de recolección de datos fue encuesta. Las Micro y pequeñas empresas son de suma importancia para la economía Nacional los mismos que se desenvuelven en un ambiente competitivo y por lo tanto es importante su participación activa dentro de este ecosistema global de transformación digital, siendo necesario la mejora en la gestión de la empresa en forma eficiente en la toma de decisiones. Muchas son las causas que las empresas se encuentran inmersas en una deficiente administración e ineficiencia de sus operaciones normales, en la falta de una adecuado manejo e incorporación de nuevas tecnologías que incrementen su productividad y sobre todo sus problemas que derivan de una escasa toma de decisiones eficiente, y es por esta razón que la presente investigación busca proponer un manejo eficiente de la gestión dentro de un cambio de cultura y pensamiento empresarial en los nuevos modelos de negocio en las Micro y pequeñas empresas en la ciudad de Arequipa. Según los resultados, se puede evidenciar, el 58.82% de las empresas casi siempre, controla y dirige a las personas a su cargo, de manera que se cumplan sus metas u objetivos previamente establecidos, mientras el 41.18% siempre adapta el proceso para mantener la competitividad. En conclusión, la implicancia de la transformación digital en la Gestión Empresarial de la Micro y Pequeña empresa fue una implicancia positiva media, siendo muy significativa.

Published
2022

46. Mejora de la planificación de la demanda de las tiendas retail propias de la empresa Crepier

Author

De la Cruz Sanchez, Julio Cesar, Falcon Paredes, Madeline Rubi, and Vidal Paredes, Alex Antonio

Subjects
Family business, Oferta y demanda, Logistica empresarial, Retail trade, Comercio al por menor, Empresas familiares, Supply and demand, Marcas comerciales, Business Logistics, Trademarks
Abstract

El presente estudio de investigación se enfocará en una mejora en el proceso de la planificación de la demanda de la empresa CREPIER con el fin de identificar los factores que afectan a la disponibilidad de productos en cada tienda retail propia de la empresa. Para diagnosticar el problema se ha tomado en cuenta el análisis interno y externo de la empresa, así como las fortalezas, debilidades, oportunidades y amenazas respectivamente. Además de detallar un diagrama de flujo y las operaciones clave de la cadena de suministro de la empresa. Con todo ello, se planteó una hipótesis, el cual se soporta del objetivo principal de la investigación, y es la implementación de un proceso de planeamiento de demanda formal con el apoyo de un software especializado creará pronósticos más acertados, reduciendo los errores en la planificación. Debido al diagrama de causa-efecto, se logró identificar las causas raíz de los principales problemas que afectan las pérdidas de ventas y excesos de inventarios. Con ello, se propuso plantear 4 propuestas de solución, las cuales se filtraron al aplicar un ranking de factores, con ello se determinó la propuesta de solución determinante es: Rediseñar el proceso con un modelo de planeamiento centralizado con modelos de reposición a locales apoyados por software especializado. Además, se hizo uso de dos principales indicadores: MAPE y % de pérdidas de cada categoría, las cuales resultaron menores al simular el uso del software especializado. Por otro lado, se obtuvo un porcentaje de la diferencia de MAPE’s, ya que con ello se obtendría la ganancia al emplear el software especializado. Finalmente, con el dato mencionado anteriormente, se realizó una evaluación económica-financiera con el uso de flujo de caja de ganancia-egreso de la mejora, la cual se evidencia un indicador beneficio-costo de 5.49 y un TIR 48%. This research study will focus on improving CREPIER's demand planning process to identify the factors that affect the availability of products in each of the company's retail stores. To diagnose the problem, the internal and external analysis of the company has been taken into account, as well as the strengths, weaknesses, opportunities and threats respectively. In addition to detailing a flow diagram and the key operations of the company's supply chain. With all this, a hypothesis was raised, which is supported by the main objective of the research, and that is the implementation of a formal demand planning process with the support of specialized software will create more accurate forecasts, reducing errors in planning. Due to the cause-effect diagram, it was possible to identify the root causes of the main problems affecting sales losses and excess inventories. With this, it was proposed to propose 4 solution proposals, which were filtered by applying a ranking of factors, thus determining the determining solution proposal: Redesign the process with a centralized planning model with local replenishment models supported by specialized software. In addition, two main indicators were used: MAPE and % of losses for each category, which were lower when simulating the use of specialized software. On the other hand, a percentage of the MAPE's difference was obtained, since this would provide the gain when using the specialized software. Finally, with the mentioned data, an economic-financial evaluation was carried out with the use of the cash flow of profit-loss of the improvement, which shows a benefit-cost indicator of 5.49 and an IRR of 48%.

Published
2022

49. Laboratories Can Reliably Detect Clinically Relevant Variants in the TP53 Gene below 10 % Allelic Frequency: A Multicenter Study of ERIC, the European Research Initiative on CLL

Author

Pavlova, Sarka, Malcikova, Jitka, Radova, Lenka, Bonfiglio, Silvia, Cowland, Jack B., Brieghel, Christian, Andersen, Mette Klarskov, Karypidou, Maria, Biderman, Bella V, Doubek, Michael, Lazarian, Gregory, Rapado, Inmaculada, Vynck, Matthijs, Porret, Naomi, Andres, Martin, Rosenberg, Dina, Sahar, Dvora, Martinez-Laperche, Carolina, Borde, Ismael Buño, Hindley, Andrew, Sánchez, Julio Bravo, García-Marco, José, Serrano, Alicia, Ferrer Lores, Blanca, Fernández-Rodriguez, Concepción, Bellosillo, Beatriz, Stilgenbauer, Stephan, Tausch, Eugen, Nikdin, Hero, Quinn, Fiona, Atkinson, Emer, Van De Corput, Lisette, Yildiz, Cafer, Bilbao, Cristina, Florido, Yanira, Thiede, Christian, Schuster, Caroline, Stoj, Anastazja, Czekalska, Sylwia, Chatzidimitriou, Anastasia, Laidou, Stamatia, Bidet, Audrey, Dussiau, Charles, Nollet, Friedel, Piras, Giovanna, Borosova, Tereza, Kurucova, Terezia, Monne, Maria, Smirnova, Svetlana, Nikitin, Evgeny, Sloma, Ivan, Delfau, Marie-Helene, Largeaud, Laetitia, Ysebaert, Loic, Valk, Peter J. M., Christian, Amy, Walewska, Renata, Sebastião, Marta, da Silva, Maria Gomes, Galieni, Piero, Angelini, Mario, Rossi, Davide, Spina, Valeria, Matos, Sónia, Martins, Vânia, Donaldson, David, Stoklosa, Tomasz, Pepek, Monika, Baliakas, Panagiotis, Andreu, Rafa, Luna, Irene, Kahre, Tiina, Murumets, Ülle, Laird, Sophie, Ward, Daniel, Alcoceba, Miguel, Balanzategui, Ana, Scarfo, Lydia, Gandini, Francesca, Zapparoli, Ettore, Blanco, Adoracion, Costa, Pau Abrisqueta, Rodriguez, Ana E., Benito Sanchez, Maria Rocio, Davi, Frédéric, Bravetti, Clothilde, Gameiro, Paula, Martinez-Lopez, Joaquin, Tazon, Barbara, Baran-Marszak, Fanny, Davies, Zadie, Caterwood, Mark, Sudarikov, Andrey B, Rosenquist, Richard, Niemann, Carsten Utoft, Stamatopoulos, Kostas, Ghia, Paolo, and Pospisilova, Sarka

Published
2023
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50. Gobierno electrónico y satisfacción del servicio a proveedores inscritos en el Organismo Supervisor de las Contrataciones del Estado. Lima 2020

Author

Ramirez Sanchez, Julio Américo and Uribe Hernández, Yrene Cecilia

Subjects
Satisfacción del cliente, purl.org/pe-repo/ocde/ford#5.06.02 [http], Contratos públicos, Gobierno electrónico
Abstract

El presente trabajo de investigación titulado “Gobierno electrónico y satisfacción del servicio a proveedores inscritos en el Organismo Supervisor de las Contrataciones del Estado. Lima 2020”, tiene por objetivo determinar la relación que existe entre las variables gobierno electrónico y satisfacción del servicio, la muestra es de 107 proveedores extranjeros domiciliados en Lima cuya inscripción al Registro Nacional de proveedores (RNP) se haya realizado en el año 2020, siendo un muestreo probabilístico de una población de 147 proveedores. Se ha empleado el método hipotético deductivo, siendo una investigación básica con diseño no experimental a nivel descriptivo, empleándose cuestionarios en un periodo de tiempo para trabajar con las variables, con una escala de Likert ordinal. El 26.17 % de los proveedores perciben la adopción del gobierno electrónico de nivel bueno, 49.53% perciben un nivel regular y 24.30% un nivel malo, además con respecto a la satisfacción del servicio el 28.04% percibe un nivel bueno, 42.99% un nivel regular y 28.07% un nivel malo. En la contrastación de las hipótesis, Existe una relación positiva y alta entre las variables. (Según los resultados de Spearman r=0,842 y p=0,00), existe una relación positiva y baja entre el gobierno electrónico y la calidad funcional percibida. (Según la prueba de Spearman r=0,412 y p=0,00), existe una relación positiva y moderada entre el gobierno electrónico y calidad técnica percibida. (Según los resultados de Spearman r=0,598 y p=0,00), existe una relación positiva y moderada entre el gobierno electrónico y el valor percibido. (Según los resultados de Spearman r=0,594 y p=0,00), existe una relación positiva y baja entre el gobierno electrónico y la confianza. (Según la prueba de Spearman r=0,373 y p=0,00) y existe una relación positiva y baja entre el gobierno electrónico y la expectativa. (Según la prueba de Spearman r=0,405 y p=0,00). Lima Norte Escuela de Posgrado Reforma y Modernización del Estado

Published
2020

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