75 results on '"Sakamoto G"'
Search Results
2. Revisión pictográfica de endoleaks (endofugas)
- Author
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Andrés Labra W, Giancarlo Schiappacasse F, Cristóbal Ramos G, Pablo Alvayay Q, and Cristián Sakamoto G
- Subjects
medicine.medical_specialty ,Aorta ,Aortic lumen ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Usually asymptomatic ,Lumen (anatomy) ,Stent ,Vascular leakage ,medicine.disease ,Aneurysm ,medicine.artery ,Angiography ,cardiovascular system ,Medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Radiology ,business - Abstract
The current treatment for aortic aneurysms is to install an endovascular stent in the aortic lumen. The most common complication of stents is endoleaks. Those defined as a peri-prosthetic vascular leak, in the aneurysm sac, are usually asymptomatic. If not detected early, they can progress with the growth and rupture of the aneurysm. The method of choice for evaluation is angiography by computed tomography (CT).The aim of this pictorial review is to describe and illustrate the imaging findings of the different types of endoleaks in computed tomography angiograms (5 types).Keywords: Aorta, CT angiography, Endoleak, Stents. Resumen: El tratamiento actual de los aneurismas aorticos es la instalacion de una endoprotesis en el lumen aortico por via endovascular. La complicacion mas frecuente de las endoprotesis son los endoleaks. Los que se definen como flujo vascular peri-protesico, en el saco aneurismatico, generalmente asintomatico. De no ser detectados a tiempo, pueden progresar con el crecimiento y rotura del aneurisma. El metodo de eleccion para su evaluacion es la angiografia mediante tomografia computada (TC).El objetivo de la presente revision pictografica es describir e ilustrar los hallazgos imaginologicos de los diferentes tipos de endoleaks en angiografia por tomografia computada (cinco tipos).Palabras clave: Angiografia por CT, Aorta, Endofuga, Endoprotesis.
- Published
- 2015
3. A Pictorial review of endoleaks
- Author
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Alvayay Q, Pablo, Schiappacasse F, Giancarlo, Labra W, Andrés, Sakamoto G, Cristián, and Ramos G, Cristóbal
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CT angiography ,Endoleak ,Endoprótesis ,Endofuga ,cardiovascular system ,Stents ,cardiovascular diseases ,Aorta ,Angiografía por CT - Abstract
El tratamiento actual de los aneurismas aórticos es la instalación de una endoprótesis en el lumen aórtico por vía endovascular. La complicación más frecuente de las endoprótesis son los endoleaks. Los que se definen como flujo vascular peri-protésico, en el saco aneurismático, generalmente asintomático. De no ser detectados a tiempo, pueden progresar con el crecimiento y rotura del aneurisma. El método de elección para su evaluación es la angiografía mediante tomografía computada (TC). El objetivo de la presente revisión pictográfica es describir e ilustrar los hallazgos imaginológicos de los diferentes tipos de endoleaks en angiografía por tomografía computada (cinco tipos). The current treatment for aortic aneurysms is to install an endovascular stent in the aortic lumen. The most common complication of stents is endoleaks. Those defined as a peri-prosthetic vascular leak, in the aneurysm sac, are usually asymptomatic. If not detected early, they can progress with the growth and rupture of the aneurysm. The method of choice for evaluation is angiography by computed tomography (CT). The aim of this pictorial review is to describe and illustrate the imaging findings of the different types of endoleaks in computed tomography angiograms (5 types).
- Published
- 2015
4. Revisión pictográfica de endoleaks (endofugas)
- Author
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Alvayay Q,Pablo, Schiappacasse F,Giancarlo, Labra W,Andrés, Sakamoto G,Cristián, and Ramos G,Cristóbal
- Subjects
Endoprótesis ,Endofuga ,Angiografía por CT ,Aorta - Abstract
El tratamiento actual de los aneurismas aórticos es la instalación de una endoprótesis en el lumen aórtico por vía endovascular. La complicación más frecuente de las endoprótesis son los endoleaks. Los que se definen como flujo vascular peri-protésico, en el saco aneurismático, generalmente asintomático. De no ser detectados a tiempo, pueden progresar con el crecimiento y rotura del aneurisma. El método de elección para su evaluación es la angiografía mediante tomografía computada (TC). El objetivo de la presente revisión pictográfica es describir e ilustrar los hallazgos imaginológicos de los diferentes tipos de endoleaks en angiografía por tomografía computada (cinco tipos).
- Published
- 2015
5. Caso clínico-radiológico para diagnóstico
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Espinoza G,Aníbal, Sakamoto G,Cristian, and Zúñiga,Francisco
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- 2014
6. Caso clínico-radiológico para diagnóstico
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Espinoza G, Aníbal, Sakamoto G, Cristian, and Zúñiga, Francisco
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- 2014
7. Estimation of Roll Restoring Moment in Long-Crested Irregular Waves
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HASHIMOTO H, UMEDA N, SAKAMOTO G, BULIAN, GABRIELE, Hashimoto, H, Umeda, N, Sakamoto, G, and Bulian, Gabriele
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- 2006
8. Revisión pictográfica de endoleaks (endofugas)
- Author
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Pablo Alvayay Q, Giancarlo Schiappacasse F, Andrés Labra W, Cristián Sakamoto G, and Cristóbal Ramos G
- Subjects
aorta ,ct angiography ,endoleak ,stents ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Medical technology ,R855-855.5 - Abstract
El tratamiento actual de los aneurismas aórticos es la instalación de una endoprótesis en el lumen aórtico por vía endovascular. La complicación más frecuente de las endoprótesis son los endoleaks. Los que se definen como flujo vascular peri-protésico, en el saco aneurismático, generalmente asintomático. De no ser detectados a tiempo, pueden progresar con el crecimiento y rotura del aneurisma. El método de elección para su evaluación es la angiografía mediante tomografía computada (TC). El objetivo de la presente revisión pictográfica es describir e ilustrar los hallazgos imaginológicos de los diferentes tipos de endoleaks en angiografía por tomografía computada (cinco tipos).
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9. Identification of Rad51 alteration in patients with bilateral breast cancer
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Kato, M., primary, Yano, K., additional, Matsuo, F., additional, Saito, H., additional, Katagiri, T., additional, Kurumizaka, H., additional, Yoshimoto, M., additional, Kasumi, F., additional, Akiyama, F., additional, Sakamoto, G., additional, Nagawa, H., additional, Nakamura, Y., additional, and Miki, Y., additional
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- 2000
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10. The Location of Positive Nodes Partly Influences the Prognostic Value of the Number of Positive Nodes in Breast Cancer Patients
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Utada, Y., primary, Kasumi, F., additional, Yoshimoto, M., additional, Tada, T., additional, Saitoh, M., additional, Takahashi, K., additional, Akiyama, F., additional, Sakamoto, G., additional, and Nishi, M., additional
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- 1999
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11. Fat intake and breast cancer risk in an area where fat intake is low: a case-control study in Indonesia.
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Wakai, K, Dillon, DS, Ohno, Y, Prihartono, J, Budiningsih, S, Ramli, M, Darwis, I, Tjindarbumi, D, Tjahjadi, G, Soetrisno, E, Roostini, ES, Sakamoto, G, Herman, S, Cornain, S, Dillon, D S, and Roostini, E S
- Abstract
Background: Associations of fat and other macronutrients with breast cancer risk are not clear in areas where fat intake is low.Methods: We conducted a hospital-based case-control study from 1992 to 1995 in Jakarta, Indonesia.Results: The study, based on 226 cases and 452 age and socioeconomic status matched controls, provided the following findings. (a) In the pre-marriage period, the greater the fat or protein consumption, the larger the risk, whereas decreasing risk with increasing carbohydrate intake was detected. The odds ratio (OR) for the highest quartile of intake relative to the lowest was 8.47 (95% CI: 4.03-17.8) for fat, 2.19 (95% CI: 1.30-3.69) for protein, and 0.16 (95% CI: 0.08-0.31) for carbohydrate. A positive association with fat and a negative one with carbohydrate were also observed for the post-marriage period, but of weaker magnitude compared to the pre-marriage period. (b) The effects of macronutrient intakes were stronger among premenopausal than among postmenopausal women. (c) Most of the associations of protein and carbohydrate were insignificant after adjustment for fat intake.Conclusions: These findings suggest that fat intake might be an important determinant of breast cancer among populations with a low fat diet in Indonesia. [ABSTRACT FROM AUTHOR]- Published
- 2000
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12. Mucinous Cystadenocarcinoma of the Breast.
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Honma N, Sakamoto G, Ikenaga M, Kuroiwa K, Younes M, and Takubo K
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We report a case of mucinous cystadenocarcinoma (MCA) of the breast in a 96-year-old woman. This is an extremely rare variant of primary breast carcinoma that bears a striking resemblance to MCAs of the ovary and pancreas. The macroscopic appearance and secretion pattern (cytologic findings) resembled cystic hypersecretory carcinoma. However, microscopically, the epithelial cells were quite different from those of cystic hypersecretory carcinoma. In the present study as well as in the literature, MCAs tend to occur more frequently in elderly women. Immunohistochemical findings suggest that they may develop independently of estrogenic stimulation. Although MCAs show high proliferative activity, the prognosis was favorable in the present case as well as in the reported cases. Because MCAs appear to have a distinct pathogenesis and biologic behavior, they should be distinguished from ordinary mucinous carcinomas, cystic hypersecretory carcinomas, and carcinomas of other histologic subtypes. [ABSTRACT FROM AUTHOR]
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- 2003
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13. Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas.
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Probst-Hensch, N M, Haile, R W, Li, D S, Sakamoto, G T, Louie, A D, Lin, B K, Frankl, H D, Lee, E R, and Lin, H J
- Abstract
Smoking and a high intake of red meat are risk factors for colorectal tumors. These effects could be due to aromatic amine carcinogens. Individual susceptibility to aromatic amines has been related to acetylation phenotype, which plays a role in the bioactivation of arylamines. Polymorphisms in both N-acetyltransferase genes, NAT1 and NAT2, have been associated with an increased risk of colorectal tumors. We studied the NAT1*10 fast acetylator allele (1088 T-->A mutation) and distal adenomas in a sigmoidoscopy-based case-control study (441 cases, 484 controls). We found neither an increased adenoma prevalence in subjects homozygous or heterozygous for the NAT1*10 fast acetylator allele (odds ratio 1.04; 95% confidence interval 0.79-1.36), nor a gene-gene interaction between NA1 and NAT2 (P(interaction) = 0.59). Further NAT1 alleles must be considered for more conclusive results regarding the relevance of NAT1 activity to colorectal tumorigenesis.
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- 1996
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14. S*P*A*R*K: A knowledge-based system for identifying competitive uses of information technology
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Gongla, P., primary, Sakamoto, G., additional, Back-Hock, A., additional, Goldweic, P., additional, Ramos, L., additional, Sprowls, R. C., additional, and Kim, C.-K., additional
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- 1989
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15. Search for diphoton events with large missing transverse energy in 7 TeV proton-proton collisions with the ATLAS detector
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N. Davidson, M. Uslenghi, Laurent Vacavant, M. Bendel, D. Schouten, J. Cammin, Gideon Bella, P. F. Zema, Wendy Taylor, Giancarlo Spigo, J. Meinhardt, R. Beccherle, Kathleen Whalen, S. Owen, Michel Lefebvre, Marcos Vinicius Silva Oliveira, D. Fassouliotis, Ralf Hertenberger, S. M. Fisher, Paul Laycock, Irakli Minashvili, A. A. Abdelalim, Corrinne Mills, Tapas Sarangi, A. Staude, Danuta Kisielewska, H. J. Burckhart, R. Dankers, Konstantin Toms, Yuri Kulchitsky, Vadim Gratchev, Si Xie, Jacqueline Batley, Manuela Venturi, Xuai Zhuang, Samira Hassani, Nikolai Rusakovich, C. J. Curtis, Gabriele Chiodini, Phillip Allport, Carlo Schiavi, Allan G Clark, Roger Moore, Anna Macchiolo, Kerstin Tackmann, E. Williams, S. Willocq, Marco Fraternali, Thibault Guillemin, C. Da Via, Stefanie Adomeit, S. Mättig, J. Farley, Kevin Varvell, V. Kral, V. A. Gapienko, G. S. Huang, M. Ibbotson, D. Su, J. T. Childers, Evgeniy Khramov, A. Ferretto Parodi, Ole Røhne, Frank Siegert, Judith Katzy, Fred Hartjes, N. D. Brett, S. De Castro, Ian Brock, G. Polesello, Vincent Hedberg, Jan Valenta, D. Traynor, M. Petteni, Yasuyuki Okumura, William Quayle, N. Skvorodnev, Y. B. Pan, O. G. Grebenyuk, Helio Takai, S. Hamilton, Yang Yang, M. Terwort, Massimo Sorbi, J. Garvey, Hans Krüger, William Brooks, M. C. Tamsett, D. Harper, M. Rescigno, V. Chernyatin, M. P. Sanders, Mous Tatarkhanov, Rashid M. Djilkibaev, Hyun-Chul Kim, Bengt Lund-Jensen, Benjamin Kaplan, Jun Wakabayashi, Lidia Smirnova, R. Kowalewski, Yaquan Fang, F. Wicek, Lukasz Zwalinski, Kirill Prokofiev, A. Palma, Reiner Hauser, S. Cuneo, Bruce Gallop, Laurent Chevalier, Tetiana Hryn'ova, Peter Hansen, Hantao Ji, J. D. Dowell, David Berge, N. De Groot, D. Roda Dos Santos, R. E. Hughes-Jones, Hiroshi Sakamoto, J. Petersen, Peter Kodys, Andreas W. W. Ludwig, Charles Taylor, C. Benchouk, M. Karnevskiy, L. Rosselet, M. Cambiaghi, Susumu Oda, A. Pickford, Shuang-Lin Li, O. B. Dogan, B. Sopko, A. I. Kononov, Gordon Watts, Fabienne Ledroit-Guillon, Kyle Cranmer, Claudio Ferretti, Aaron Angerami, J. Lundquist, R. Perrino, Tohru Takeshita, P. J. Clark, Bellisario Esposito, E. Cogneras, Vadim Kantserov, M. Hauschild, N. Boelaert, A. Kocnar, Alejandro Alonso, Mustafa Yilmaz, J. P. Archambault, S. Walch, Giovanni Darbo, K. Nagai, Iskander Ibragimov, Klaus Hamacher, M. D. Ciobotaru, B. Guo, Valerio Dao, Peter Buchholz, G. A. Odino, T. Perez Cavalcanti, Jian Wang, L. Rumyantsev, J. W. Schumacher, Marianna Testa, P. N. Ratoff, B. Auerbach, Tatiana Klioutchnikova, Dilip Jana, R. K. Bock, Stefan Valkar, Rostislav Konoplich, M. Lungwitz, Graeme Stewart, Zdenek Dolezal, J. E. García Navarro, Kerstin Jon-And, L. Xaplanteris, G. Cataldi, M. Sosebee, Jacob Searcy, Massimiliano Bellomo, Borut Paul Kerševan, Arthur Moraes, Barbara Wosiek, D. Joffe, J. Z. Will, Uwe Bratzler, Pierre-Antoine Delsart, S. Vallecorsa, K. Fowler, A. Papadelis, Tancredi Carli, T. Stahl, K. Stevenson, Roberto Cardarelli, Mark Sutton, José Salt, S. Nelson, Abdeslam Hoummada, D. H. Saxon, Laura Jeanty, T. Buran, Markus Elsing, Lee Sawyer, Sally Seidel, Peter Onyisi, Mattias Ellert, M. Losada, Filippo Maria Giorgi, P. M. Tuts, T. Ohsugi, K. H. Hiller, K. Mahboubi, J. Silva, Kiyotomo Kawagoe, Jean-Francois Arguin, D. Urbaniec, A. Vogel, Veysi Erkcan Ozcan, Andreas Petridis, Gianluca Alimonti, Rainer Stamen, T. B. Sjursen, G. Hughes, Urmila Soldevila, Alberto Mengarelli, P. D. Thompson, C. Carpentieri, S. Swedish, M. S. Kayl, M. Kurata, M. Schmitz, Patrick Fassnacht, I. Ludwig, Andrew Pilkington, Christos Anastopoulos, Bianca Osculati, Bobby Samir Acharya, H. A. Neal, P. Ruzicka, C. Cowden, J. Hoffman, M. T. Pérez García-Estañ, G. Bachy, Guillaume Unal, J. T. Linnemann, Andreas Hoecker, A. N. Sisakyan, A. Artamonov, A. V. Larionov, R. C. W. Henderson, M. J. Shochet, Alexandre Rozanov, Edmund Dawe, Claudio Santoni, Y. A. Tikhonov, David Yu, Evgeny Starchenko, M. Mechtel, C. Padilla Aranda, Kate Shaw, Juerg Beringer, A. Jantsch, Mathieu Benoit, K. Bernardet, Nicola Venturi, Yuji Yamazaki, H. Ghazlane, Guosheng Xu, G. Cattani, A. Astbury, C. Cerna, G. Kilvington, L. Micu, Stefan Schlenker, Liron Barak, Alexander Undrus, Tatsuya Masubuchi, E. Rulikowska-Zarebska, Oliver Keith Baker, John Alison, Sara Valentinetti, Frank Winklmeier, L. R. Flores Castillo, S. D. Kolya, Luc Poggioli, Christine Kourkoumelis, Pedro Jorge, Gvantsa Mchedlidze, Sarah Heim, E. van der Poel, Uladzimir Kruchonak, Mauro Iodice, Gideon Alexander, B. Rensch, Cristian Stanescu, P. J. Bell, S. V. Mouraviev, P. Branchini, D. Lopez Mateos, Harald Joerg Stelzer, Massimo Antonelli, Maia Mosidze, J. A. Strong, G. Gorfine, Pavel Shatalov, Jochen Dingfelder, J. R. Keates, Alex Kastanas, R. Froeschl, Alaettin Serhan Mete, B. G. Pope, Robert P. Ely, S. A. Gorokhov, T. Byatt, A. D. Doxiadis, M. Dwuznik, Jolanta Olszowska, Lorne Levinson, K. Yamamoto, Hui Li, J. L. Schlereth, A. Christov, Sigve Haug, N. Austin, Ovsat Abdinov, L. E. Kirsch, M. Perantoni, A. G. Schamov, J. Odier, G. Usai, Joe Kroll, Daniel Lellouch, K. K. Joo, A. Leger, S. Heisterkamp, A. Engl, A. Roe, David Calvet, Mitsuaki Nozaki, M. Tyndel, E. Berglund, Davide Costanzo, M. G. Wilson, J-P. Meyer, A. Guida, G. Carlino, Frank Fiedler, Giovanni Maccarrone, Vaclav Vrba, Francois Touchard, M. I. Pedraza Morales, W. J. Mills, J. Dubbert, Jean-Francois Grivaz, A. Manabe, Janet Dietrich, Martin Hoeferkamp, V. Giangiobbe, Jiri Dolejsi, Alastair Dewhurst, Ulrich Husemann, Heinz Pernegger, Alexander Oh, A. Manousakis-Katsikakis, J. Lesser, N. Grigalashvili, D. Gillberg, S. Mitsui, Rupert Leitner, Leonardo Paolo Rossi, Z. Qian, John H. L. Hansen, P. de Jong, Claudio Luci, S. De Cecco, Trevor Vickey, G. Schuler, Phillip Gutierrez, Y. Rodriguez Garcia, R. Yoshida, Dimitrios Iliadis, A. Taga, Jun Guo, T. J. Brodbeck, Kirika Uchida, Hisaya Kurashige, M. King, Joern Grosse-Knetter, Sergio Grancagnolo, C. Borer, Sabine Crépé-Renaudin, Osamu Sasaki, Carlos Solans, S. George, Miriam Watson, Milos Lokajicek, P. Waller, Steven Ahlen, C. Santamarina Rios, D.P.S. Ferguson, K.M. Smith, F. Mueller, Thorsten Kuhl, Nikolaos Konstantinidis, R. Sandstroem, João Carvalho, S. Lockwitz, C. Bacci, Shuwei Ye, Jennifer A. Love, Alberto Aloisio, A. Nikiforov, Y. Morita, Oleg Brandt, J. Hartert, Mara Senghi Soares, R. J. Miller, B. C. LeGeyt, E. Reinherz-Aronis, Sh. Yamamoto, J. Cook, Dominik Dannheim, Cesare Bini, Zhen Yan, K. Skovpen, Rodney Walker, C. Tsarouchas, S. Gadomski, M. Ugland, T. C. Meyer, A. T. H. Arce, Jamal Eddine Derkaoui, Arno Straessner, C. U. Felzmann, F. Butin, Sébastien Viret, B. Chapleau, Denis Salihagic, B. Jackson, Markus Cristinziani, Wolfgang Liebig, Lourenco Lopes, M. Shimojima, Michael Andrew Parker, Susanne Kuehn, Xifeng Ruan, Johannes Haller, Efstathios Paganis, Maurizio Piccinini, Neil Collins, Edward Diehl, L. Batkova, I. Gough Eschrich, S. Tanaka, M. Corradi, L. Zhao, Monica D'Onofrio, I. Nasteva, Driss Benchekroun, Jos Vermeulen, D. Breton, Konstantinos Nikolopoulos, A. Bruni, Teng Jian Khoo, Kunihiro Nagano, L. Moneta, S. Eckweiler, B. Budick, I. Wilhelm, M. De Oliveira Branco, N. I. Bozhko, D. V. Dedovich, Elizaveta Shabalina, J. Ferland, Andrea Sansoni, J. Poll, G. Ordonez, S. Baker, L. M. Gilbert, G. T. Jones, M. Cirilli, Alison Lister, J. A. Gray, Rinat Fakhrutdinov, E. Spiriti, Stefania Spagnolo, R. Porter, Martine Bosman, H. Nomoto, E. Hazen, Sergio Gonzalez-Sevilla, M. Mikuž, Y. Zolnierowski, E. J. Buis, M. Aurousseau, M. Groh, Lucio Cerrito, Kerstin Lantzsch, Jochen Schieck, C. Belanger-Champagne, T. Del Prete, John Rutherfoord, Massimo Caccia, Holger Schulz, A. Phan, Filippo Ceradini, Krzysztof Korcyl, S. Campana, Martin Maß, S. T. French, C. A. Magrath, R. Schwierz, J. Knobloch, V. M. Romanov, Andrea Catinaccio, Rachel Maria Avramidou, Cigdem Issever, Song-Ming Wang, A. Leung Fook Cheong, Jana Schaarschmidt, I. A. Christidi, N. Ghodbane, D. Kuhn, D. Evangelakou, M. J. Oreglia, H. Wahlen, Stan Bentvelsen, T. Vu Anh, G. Volpini, Stefan Kaiser, Shigeru Odaka, H. von Radziewski, Daniel Muenstermann, I. Massa, A. J. Martin, C. Vellidis, Christophe Clement, J. Weber, Vipul Jain, Dominique Pallin, Rosy Nicolaidou, C. Pizio, Timothy Andeen, C. Grah, Z. Zhan, Jianming Qian, G. Tong, A. Borisov, Vincenzo Canale, W. Iwanski, A. G. Myagkov, L. Duflot, K. Jelen, E. Petit, Andrey Soukharev, A. Hidvegi, B. Nicquevert, A. Bertin, M. Tylmad, Calin Alexa, C. Wright, J. A. Bogaerts, T. N. Addy, Zhijun Liang, F. Bertinelli, Tomas Sykora, Jyothsna Rani Komaragiri, Mark Slater, Valery Schegelsky, F. Garberson, K. E. Johansson, Mark Stockton, Yoichi Ikegami, L. Chikovani, Pavol Strizenec, V. Sopko, V. A. Korotkov, Siegfried Wenig, T. J. Sloan, I. Torchiani, Jovan Mitrevski, Murrough Landon, Peter Jenni, Q. T. Shao, Hongfang Liu, S. Aoun, P. Giusti, J. Sloper, Paul Tipton, Margherita Primavera, A. Do Valle Wemans, M. Kelly, M. Strang, Olivier Arnaez, T. Akdogan, Elliot Lipeles, Saleh Sultansoy, C. Daum, R. Tanaka, T. Göpfert, I. Turk Cakir, Andreas Warburton, M. Ramstedt, M. C. Morone, Kazunori Hanagaki, G. Nanava, M. E. Zeller, E. Sedykh, G. Calderini, Carmen García, J. Lys, F. Föhlisch, Allen Mincer, M. V. Purohit, Uli Schäfer, Dirk L. Hoffmann, Junji Tojo, Ehud Duchovni, A. G. Kholodenko, S. J. Park, Paolo Camarri, Stefan Tapprogge, Mario Lassnig, A. Maio, C. Conta, Ralf P. Richter, Christopher J. Kenney, B. M. Waugh, F. Sarri, A. S. Kozhin, David Francis, Marcello Fanti, J. Colas, A. J. Lowe, A. Boveia, Ki Lie, T. Spreitzer, K. Miyazaki, J. Machado Miguens, Fumihiko Ukegawa, Andrea Formica, Venetios Polychronakos, V. Perez Reale, Yona Oren, R. A. McLaren, Eram Rizvi, L. La Rotonda, I. Hruska, M. Villaplana Perez, R. Herrberg, C. P. Buszello, Stephanie Majewski, Daniel Fournier, P. Yu Nechaeva, Xiaohu Sun, I. Stekl, P. Steinbach, G. M. Kolachev, Marzio Nessi, E. Jankowski, Martin Rybar, A. Seiden, T. Hayakawa, James Catmore, Robert Kehoe, W. E. Cleland, Renat Sadykov, Rudiger Voss, Georges Azuelos, Nick Barlow, Barry King, F. Alessandria, Helena Santos, Ricardo Neves, Fred R. Hirsch, Bertrand Laforge, K. H. Becks, G. Luijckx, David J. Smith, A. Filippas, O. Gutzwiller, M. Della Pietra, S. Gonzalez, Marco Schioppa, I. Jen-La Plante, G. Tzanakos, Andrea Bocci, M. Cooke, B. Sellden, K. K. Temming, Y. F. Ryabov, Nikola Makovec, Dave Charlton, Xiaoqin Li, Hulin Wang, A. Ahmad, Corinne Goy, C. Lapoire, Diane Cinca, Reiner Klingenberg, Helmut Wolters, Vladimir Nikolaenko, Z. Weng, A. Penson, Ian Michael Nugent, Muhammad Alhroob, P. Conde Muiño, Evelina Vassileva Bouhova-Thacker, Eugen Ertel, Georgios Tsipolitis, Sven Menke, A. Lupi, Mogens Dam, Victor Maleev, Karl Jakobs, Xie Yijin, Peter Schacht, Mauro Donegà, M. Jimenez Belenguer, M. Turala, O. Kvasnicka, H. Czirr, Frank Paige, Else Lytken, Charles Leggett, M. Rammes, Fabian Huegging, C. M. Hawkes, A. M. Zaitsev, F. Broggi, T. Mclaughlan, M. Mazzanti, E. De La Cruz-Burelo, J. R.A. Booth, D. Fasching, C. Ruwiedel, Thorsten Wengler, O. C. Jonsson, V. Savinov, Murdock Gilchriese, I. Satsounkevitch, F. Quinonez, Andrea Ventura, Michael Solar, A. Bangert, B. Åsman, M. Klemetti, Oldrich Kepka, F. Cataneo, A. Richards, Ulrich Parzefall, M. Ziolkowski, Alexander Bogdanchikov, Amanda R. Vest, Speranza Falciano, V. Kaushik, T. Meguro, Andreas Redelbach, Farid Ould-Saada, L. De Mora, B. Gosdzik, K. Facius, A. Di Ciaccio, C. Driouichi, Michael A. Strauss, M. Johansen, Voica Radescu, Driss Goujdami, C. Suhr, J. A. Parsons, Stefan Koperny, Julie Kirk, Susanne Kersten, Sebastian Grinstein, R. Ichimiya, Wolfgang Mader, Kendall Reeves, H. Landsman, C. Topfel, B. De Lotto, Emmerich Kneringer, D. van der Ster, Donatella Cavalli, U. Mallik, Mikhail Mineev, John Penwell, P. Hansson, Heiko Lacker, A. Kreisel, J. A. Ernst, F. Etienne, R. Mameghani, G. Lenzen, Dave Britton, Chiara Roda, Børge Kile Gjelsten, A. J. Fowler, James Boyd, D. Romero Maltrana, X. S. Anduaga, A. V. Ivashin, P. Miele, Dimitris Varouchas, Manolis Dris, G. Mahout, Shogo Okada, C. Guicheney, H. J. Yang, Juergen Kroseberg, A. T. Doyle, L. Labarga, B. Gaur, Dominick Olivito, Karel Smolek, Werner Wiedenmann, J. M. Foster, E. Castaneda-Miranda, A. G. Olchevski, Markus Schumacher, Frederic Brochu, Ryszard Stroynowski, T. Doherty, J. R. Lessard, Paul Nilsson, S. Prasad, D. Pomeroy, Alberto Annovi, M. Imhaeuser, Armin Michael Nairz, A. Reinsch, D. Whittington, A. A. Carter, Roger Jones, A. Firan, E. Bergeaas Kuutmann, Are Strandlie, Andrew Brandt, Fernando Marroquim, Frank Seifert, R. Engelmann, M. Wittgen, Ariel Schwartzman, S. Fratina, J. M. Maugain, A. Loginov, Marumi Kado, E. Urkovsky, James Frost, Pier-Olivier Deviveiros, Jonas Strandberg, M. Uhrmacher, A. Beddall, N. Giokaris, Giora Mikenberg, Wouter Verkerke, C. J.W.P. Timmermans, Lixin Ma, D. Typaldos, A. D'Orazio, H. von der Schmitt, E. Valladolid Gallego, X. Espinal Curull, Diego Casadei, Doris Chromek-Burckhart, Tadaaki Isobe, J. N. Lilley, M. Cascella, W. Ji, Tatsumi Koi, Maurice Garcia-Sciveres, V. V. Zmouchko, P. Perus, T. Kobayashi, Petr Andreevich Gorbounov, Torre Wenaus, D. Milstein, Dominic Hirschbuehl, S. Sandvoss, P. Federic, G. A. Chelkov, Alex Martyniuk, Wolfgang Wagner, A. Chilingarov, Marie-Hélène Genest, S. Subramania, O. Vitells, Carsten Hensel, M. Dameri, Luca Fiorini, G. Y. Mitrofanov, Alberto Belloni, M. Leahu, Aldo Saavedra, Atsuhiko Ochi, F. Polci, M. Maaßen, S. Di Luise, James Howarth, Stephen Haywood, Sotirios Vlachos, Walter Lampl, V. Moeller, S. Zenz, J. Inigo-Golfin, David Malon, Stefan Guindon, D. Lumb, B. M. Hawes, E. Dobson, E. Sarkisyan-Grinbaum, Ewa Stanecka, Enrico Tassi, F. Marzano, G. Nunes Hanninger, Jean François Marchand, Jens Dopke, Gokhan Unel, F. Dudziak, Richard Brenner, Marisa Sandhoff, A. Mitra, B. Radics, S. Y. Nesterov, Arely Cortes-Gonzalez, Alexander Milov, A. Irles Quiles, Matthias Klein, Alexey Talyshev, R. Giordano, Vladimir Cindro, Pierre-Hugues Beauchemin, M. Weber, A. Reichold, Konrad Kleinknecht, R. Maenner, Teresa Barillari, V. M. Kotov, Seema Bahinipati, Y. Ilchenko, G. Romeo, Marine Kuna, M. Kenyon, Sara Diglio, Steven Goldfarb, Z. G. Zhao, G. Ciapetti, Peter Loch, W. Mohr, J. B. De Vivie De Regie, Jan Kretzschmar, D. R. Quarrie, E. E. Schmidt, F. Parodi, D. Fellmann, C. C. Young, Anna Kaczmarska, N. Grau, Marina Cobal, A. Tonazzo, David Miller, Jiri Masik, Lawrence Lee, Oleg Fedin, S. Vahsen, W. T. Meyer, Dorothee Schaile, Michael Boehler, Bartosz Mindur, Lianyou Shan, Richard Nisius, Melissa Ridel, C. W. Loh, Jianyong Lu, Srinivasan Rajagopalan, Irene Vichou, Hal Evans, B. A. Dolgoshein, Y. Mahalalel, J. Snow, Ilija Vukotic, Jan Godlewski, M. Rijpstra, Jalal Abdallah, E. Strauss, G. Vegni, C. Schmitt, Erez Etzion, M. Werner, Francois Corriveau, Scott Snyder, Carlos Lacasta, Masaya Ishino, E. Turlay, Elias Coniavitis, K. 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Rador, Isabel Marian Trigger, Louise Skinnari, R. J. Homer, Antonio Baroncelli, Ulrich Landgraf, J. Schultes, Mauro Villa, N. Panikashvili, Claire Gwenlan, Vincent Garonne, M. Hohlfeld, X. Portell Bueso, Sandro Palestini, J. Snuverink, R. R. Rios, S. Rodier, I. Dolenc, J. Lellouch, D. Y. Bardin, L. Miralles Verge, E. Auge, R. W. Clifft, G. Brown, Andre Kruth, Julien Donini, Pascal Pralavorio, Ilias Efthymiopoulos, Sandra Kortner, S. Fazio, V. Vorwerk, Vadim Kostyukhin, Lamberto Luminari, M. Shamim, Y. Pylypchenko, Catrin Bernius, Remi Lafaye, Theodota Lagouri, G. Cortiana, Paolo Iengo, M. Marx, S. I. Buda, Hartmut Sadrozinski, K. W. McFarlane, N. Massol, Douglas M. Hawkins, D. S. Popovic, E. L. Barberio, Marco Delmastro, M. Fiascaris, Marina Rotaru, N. Dressnandt, Frédéric Chevallier, H. van der Graaf, S. N. White, Ilya Korolkov, Fridolin Dittus, Y. Munwes, Moritz Backes, Sofia Chouridou, Jason Nielsen, Armen Vartapetian, Maria-Teresa Dova, P. Giovannini, E. Ptacek, Tom McCarthy, M. C. Conidi, Zhiqing Zhang, A. Paoloni, R. Febbraro, M. Warsinsky, M. S. Levitski, E. Laisne, Bernard Aubert, Benjamin Trocmé, M. Moreno Llácer, Bing Li, Shlomit Tarem, Gabriela Navarro, J. Klaiber-Lodewigs, Tiesheng Dai, J. J. Veillet, J. Morel, Guennadi Borissov, Francesco Lacava, M. Tsiakiris, Michael Begel, L. De Nooij, S. Hillert, S. Persembe, M. Saleem, Gustaaf Brooijmans, Dirk-Uwe Bartsch, M. E. Sevior, Gabriella Gaudio, E. Solfaroli Camillocci, C. Del Papa, B. Szeless, K. Perez, P. Stavina, Gerjan Bobbink, Marisilvia Donadelli, Judita Mamuzic, Uta Klein, Maria Smizanska, D. Goldin, D. Imbault, N. Krieger, P. Matricon, M. Abolins, V. N. Goryachev, A. Tonoyan, M. Virchaux, J. A. Wilson, P. V.M. Da Silva, Takahiko Kondo, William Buttinger, S. P. Whitaker, B. M. Salvachua Ferrando, A. Canepa, J. Molina-Perez, I. van Vulpen, Andrzej Zemla, Giulio Aielli, Fernando Barreiro, Itamar Roth, Iacopo Vivarelli, M. Dosil, Xin Wu, Z. Zajacova, Eduardo Ros, Till Eifert, M. I. Gostkin, Per Werner, Simon Head, M. Lichtnecker, E. Oliver Garcia, E. Griesmayer, Shi Liu, Akira Yamamoto, T. Costin, E. I. Rosenberg, C. Dionisi, Paul Miyagawa, Nurcan Ozturk, M. J. Price, R. Marshall, Fr. Pastore, Aziz Chafaq, M. Ackers, George Stavropoulos, K. Randrianarivony, S. Malyukov, Tomas Slavicek, Toyonobu Okuyama, K. Tollefson, M. Kollefrath, Dugan O'Neil, D. Axen, Caroline Collard, Lydia Iconomidou-Fayard, Emmanuel Monnier, S. Yanush, Dj. Sijacki, K. Dindar Yagci, N. Soni, Sophie Henrot-Versille, M. Kuze, J. Alonso, A. Kasmi, S. Migas, S. Zheng, Andrea Knue, Camilla Juul Hansen, Y. Itoh, Amir Farbin, G. Sellers, Miao Liu, Minoru Hirose, A. Dotti, V. V. Lapin, R. Wunstorf, Viktor Kramarenko, Sarah Demers, A. Jeremie, M. He, A. Braem, D. Macina, T. Tic, Adam Trzupek, D. De Pedis, W. Bhimji, V. Rossetti, Iwona Grabowska-Bold, G. Rahal, Abner Soffer, A. Gaponenko, F. Rühr, G. N. Taylor, Pai-hsien Jennifer Hsu, D. Kollar, G. H. A. Viehhauser, Tomas Davidek, F. Dydak, Y. Yao, S. Thoma, Polina Kuzhir, A. Morais, Isabelle Wingerter-Seez, Alessandro Tricoli, P. Lichard, B. Epp, Ann E. Nelson, R. M. Buckingham, A. A. Salnikov, Sandrine Laplace, R. Pengo, C. P. Marino, Vincenzo Izzo, F. Marchese, D. C. Rodriguez, Alexey Maslennikov, F. Anulli, Y. Benhammou, Evgueni Ladygin, Gabriella Pasztor, S. V. Kopikov, Michel Raymond, C. M. Tevlin, T. A. Dietzsch, Bruce Schumm, R. S. B. King, N. Schroer, Serkant Ali Cetin, Margret Fincke-Keeler, Susan Cheatham, Benjamin Ko, P. Haefner, Reda Tafirout, Klaus Kurt Desch, Richard Nickerson, Leonardo Merola, F. Salvatore, Torsten Harenberg, M. Henke, P. Ge, Kathy Pommès, Mark Owen, H. Takeda, Nuno Filipe Castro, Laura Fabbri, Prafulla Kumar Behera, Chariclia Petridou, Iftach Sadeh, B. Fernandes, Jörgen Sjölin, E. Torró Pastor, S. Michal, G. Khoriauli, R. Di Sipio, K. Nakamura, Benjamin Brau, F. Canelli, Nazim Huseynov, Halina Bilokon, Haiping Peng, Emilio Higón-Rodriguez, I. Rubinskiy, Kevin Black, Jean-Francois Laporte, Pamela Ferrari, A. J.M. Muijs, P. Renkel, Christopher Lester, Robert Harrington, Antonio Sbrizzi, Johannes Erdmann, Remi Zaidan, W. Fernando, S. W. O'Neale, A. Coccaro, Andrew White, R. Lifshitz, James W. Bremer, Sw. Banerjee, A. Muir, T. Lari, C. Zeitnitz, S. Caughron, Arnulf Quadt, Michal Vlasak, Lily Asquith, Frank Berghaus, M. J. Kobel, T. W. Jones, Anna Goussiou, Petr Gallus, K. Murakami, R. J. Teuscher, Joaquin Poveda, Timothee Theveneaux-Pelzer, K. Ishii, F. S. Merritt, Lidia Dell'Asta, P. Mättig, S. S.A. Livermore, Ye Zhu, D. Kharchenko, D. M. Seliverstov, R. Placakyte, R. P. Middleton, C. Schroeder, Fabrice Hubaut, M. L. Andrieux, C. Boulahouache, Dario Barberis, L. Lu, Mark Neubauer, V. Lendermann, Philippe Ghez, J. Bouchami, P. Delpierre, F. Bucci, T. Kittelmann, I. Borjanovic, Arnaud Lucotte, B. C. Smith, C. Shaw, Christophe Royon, D. Tsionou, P. J. Magalhaes Martins, S. I. Kazi, V. N. Gushchin, M. Vranjes Milosavljevic, Y. A. Kurochkin, Alexey Zhemchugov, A. Abdesselam, M. I. Scherzer, Kristin Lohwasser, R. Alon, Christopher Potter, H. Ten Kate, B. H. Benedict, Ariella Cattai, T. Kluge, K. Tokunaga, H. Dietl, J. Boek, T. Ohshima, Dmitri Tsybychev, R. L. McCarthy, Vasiliki A Mitsou, Jan Jakubek, S. J. Dallison, G. Rybkin, L. S. Gomez Fajardo, Thomas LeCompte, C. Caso, M. Lehmacher, B. Martin dit Latour, A. Yurkewicz, Woiciech Fedorko, S. Borroni, Stephen Lloyd, D. Arutinov, Francesco Conventi, Evelin Meoni, A. Dahlhoff, Arnaud Ferrari, Y. Hernández Jiménez, A. Di Mattia, Carolina Gabaldon, Stefan Stonjek, Shoji Asai, Jan Strube, Jiangyong Jia, Philippe Mermod, R. Kwee, Kevin Kroeninger, T. Yamamura, M. Consonni, T. Burgess, Frantisek Krejci, E. Badescu, E. Acerbi, F. Hahn, Mark Hodgkinson, J. E.M. Robinson, C. T. Potter, K. Ellis, John Joseph, Sascha Caron, Vladimir Sulin, V. Ferrara, L. Bellagamba, Igor Mandić, S. Carron Montero, G. P. Tappern, D. R. Botterill, Sourav Poddar, Petr Sicho, T. Ince, Naoko Kanaya, Alexandre Vaniachine, F. Cevenini, P. Booth, G. F. Gieraltowski, S. Winkelmann, V. I. Vassilakopoulos, J. E. Brau, E. Brubaker, M. Leltchouk, Christopher Bee, Petr Vokac, Ning Zhou, A. Harvey, V. Bansal, Michael Düren, Tobias Golling, Nicolas Berger, Jiri Chudoba, R. Mackeprang, T. Kohriki, M. Medinnis, J. Virzi, S. Eckert, Raymond Veness, M. J. Kotamäki, Eiliv Lund, Helen Hayward, P. M. Watkins, G. W. Brandenburg, Roberto Spighi, I. Aracena, S. Haas, S. Ask, M. S. Alam, Giuseppe Francesco Tartarelli, R. Santonico, Thomas Lohse, S. König, Liza Mijović, S. H. Robertson, I. Fedorko, S. Behar Harpaz, Dan Pantea, A. Gonidec, J. G. Rocha de Lima, R. Davidson, E. Torrence, M. Leyton, A. Gupta, M. D. Joergensen, Alexander Kupco, Edoardo Gorini, M. Kataoka, M H. Lehto, S. W. Snow, T. K.O. Doan, S. Correard, D. Côté, Aston Komar, R. Duxfield, Y. Silver, B. J. O’Brien, Y. V. Grishkevich, John Stupak, T. Horazdovsky, J. Antos, M. S. Kim, Louis Fayard, Z. Zenonos, Sylvain Tisserant, Wolfgang Walkowiak, I. Rottländer, P. de Saintignon, Metin Arik, G. Chiefari, H. Matsumoto, C. P. Ward, D. della Volpe, Fernando Monticelli, I. Stumer, Peter Krieger, Michel Vetterli, D. Buira-Clark, B. Ruckert, J. de Graat, Heidi Sandaker, A. Ishikawa, Sten Hellman, R. Cherkaoui El Moursli, M. Beimforde, W. Kuykendall, L. Shaver, G. Mirabelli, J. Thadome, Henso Abreu, Matt Dobbs, C. L. Lampen, Norbert Wermes, D. Merkl, R. E. Long, B. Clement, Q. Ouyang, Marjorie Shapiro, Soshi Tsuno, T. Kawamoto, Sara Strandberg, C. Valderanis, R. Piegaia, B. Caron, Stephen Maxfield, T. N. Trinh, C. J. Oram, Cedric Serfon, Stephen Gibson, H. Zhang, Phillip Urquijo, V. I. Kolesnikov, S. E. Allwood-Spiers, Deepak Kar, Jianqiao Ye, Y. Azuma, Petre Dita, Jialun Ping, Torsten Paul Ake Åkesson, A. Gutierrez, Aleandro Nisati, E. Vinek, V. Martinez Outschoorn, G. Rivoltella, A. S. Cerqueira, Mika Huhtinen, Giorgio Bellomo, T. Ženiš, U. K. Yang, Sascha Mehlhase, C. 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Cavalleri, A. Henrichs, J. J. Goodson, V. Boldea, Ivan Sykora, S. Nektarijevic, Andrey Kiryunin, Peter Nemethy, P. Johansson, Marc Weber, Katharine Leney, William Trischuk, M. Aderholz, V. Chavda, T. R. McMahon, Shaun Roe, Matthew Beckingham, Sourabh Dube, X. Y. Zhang, Z. Hajduk, B. DeWilde, A. Passeri, N. J. Buchanan, Stefania Xella, B. Brelier, M. Panuskova, Dimitrios Sampsonidis, Imma Riu, A. V. Zenin, O. M. Kind, A. Poblaguev, B. Fatholahzadeh, D. Hill, Toshi Sumida, Kenneth Wraight, D. Wicke, Fr Pastore, A. Tua, P. Grafström, John Hobbs, Naoki Kimura, F. Baltasar Dos Santos Pedrosa, L. Tremblet, Nicolas Morange, David Milstead, Kevin Einsweiler, Tony Liss, Howard Gordon, P. Francavilla, Elisabetta Vilucchi, B. Beare, H. McGlone, A. Di Simone, G. D. Carrillo Montoya, G. Ionescu, B. Martin, A. Gomes, André Schöning, Haleh Khani Hadavand, S. Yu. Sivoklokov, P. Farthouat, O. Krasel, Bruce Barnett, M. A. B. do Vale, Giuseppe Salamanna, K. J. Anderson, Zuzana Rurikova, J. Solc, Noam Hod, A. Dos Anjos, Samuel Calvet, Simonetta Gentile, R. Prabhu, Pavel Tsiareshka, Javier Sánchez, F. Safai Tehrani, K. E. Arms, M. Uhlenbrock, J. Schwindling, Axel König, O. K. Øye, A. Tykhonov, Andrew Mehta, R. Wall, A. La Rosa, I. M. Gregor, Tetsuro Mashimo, V. Paolone, P. Sinervo, C. A. Edwards, M. L. Chu, K. Gellerstedt, Yu M. Sviridov, J. Mechnich, C. H. Wang, S. Haider, Simon Lin, H. Drevermann, J. Kaplon, Igor Aleksandrov, Emily Nurse, M. Biglietti, G. Choudalakis, Z. van Kesteren, H. Ohshita, K. Copic, T. Barber, C. Dallapiccola, J. Ernwein, M. Battistin, Yousuke Kataoka, L. M. Mir, Yorihito Sugaya, Jed Biesiada, L. Mandelli, Josh Mcfayden, Fabrizio Petrucci, Elizabeth Gallas, Jianbei Liu, A. B. Fenyuk, M. Gouighri, I. Reisinger, Ph. Schwemling, Andrei Akimov, T. K. Ohska, E. Galyaev, M. D. M. Capeans Garrido, T. Sandoval, P. Koevesarki, Miroslav Myska, P. Morettini, Raimund Ströhmer, Alessandra Doria, R. Spiwoks, Jean-Christophe Gayde, Miroslav Havranek, V. 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Resende, Orhan Cakir, Michael Kagan, Michael Hance, A. J. Barr, A. Lazzaro, Carl Gwilliam, Emilio Petrolo, L. Nicolas, M. Mazur, Alexander Mann, O. Gildemeister, S. C. Hsu, Lorenzo Feligioni, V. A. Giakoumopoulou, P. M. Prichard, M. Davies, Halina Abramowicz, Paolo Calafiura, Gerhard Brandt, C. Mattravers, E. Devetak, S. Prell, K. Horton, J. Miao, R. Bruneliere, Nimrod Taiblum, M. zur Nedden, Marcel Vreeswijk, Joshua Kunkle, P. Banerjee, Peter Loscutoff, A. Di Girolamo, J. B. Blanchard, Ikuo Ueda, D. M. Strom, Frederic Derue, B. Spurlock, R. W. Hackenburg, Bing Zhou, H. Tyrvainen, Christoph Rembser, Irinel Caprini, K. Amako, L. G. Johansen, T. Loddenkoetter, Giacomo Artoni, P. Malecki, J. Barreiro Guimarães da Costa, G. Fischer, Sergey Burdin, Dmitry Emeliyanov, J. C. Clemens, Yasuhiro Makida, Steve McMahon, Robert Gardner, A. A. Minaenko, N. D. Patel, F. K. Loebinger, Didier Ferrere, Odette Benary, B. T. Gorski, Mihai Caprini, J. Gunther, T. Dohmae, E. J. W. Moyse, Daniel Whiteson, Bradley Cox, Vladimir Peshekhonov, S. Aefsky, P. Coe, S. Marti-Garcia, Andrzej Olszewski, M. Flechl, L. Aperio Bella, A. Da Rocha Gesualdi Mello, I. Bozovic-Jelisavcic, Alexander Solodkov, Jie Zhang, James H Cochran, Trygve Buanes, A. Neusiedl, D. Petschull, A. Gemmell, Tord Ekelof, Monica Verducci, T. Moa, Zeno Dixon Greenwood, Yu Nakahama, Marco Costa, Trisha Farooque, H. G. Moser, J. Schovancova, Andrew Buckley, F. Niedercorn, S. P. Denisov, Fred Wickens, J. P. Martin, M. A. Thomson, Martin Spousta, E. B. Klinkby, M. Y. Kazarinov, B. Toggerson, Ian Dawson, E. N. Thompson, M. Holder, Alexander Paramonov, A. Shibata, R. Dhullipudi, G. Amorós, G. Lehmann Miotto, M. Teixeira Dias Castanheira, M. Deile, Theodoros Alexopoulos, Marcela Mikestikova, T. Nattermann, Bettina Mikulec, T. Chen, Martin Tripiana, N. C. Ryder, Lauren Tompkins, J. Stahlman, Ivor Fleck, M. Franklin, Vakhtang Tsulaia, Michal Suk, Siegfried Bethke, Caterina Doglioni, Stanislav Tokár, F. Grancagnolo, Christoph Falk Anders, J. Del Peso, J. Ebke, R.W. Dobinson, Philippe Calfayan, K. Leonhardt, Laurent Serin, P. van Gemmeren, F. E. Taylor, James Pinfold, Benedetto Giacobbe, V. Sipica, G. B. Taylor, D. Levin, G. A. Rosenbaum, E. Fullana Torregrosa, D. Zhang, J. P. Ottersbach, T. Fonseca Martin, Antonio Zoccoli, C. Goeringer, R. Mandrysch, J. Ginzburg, Takashi Kubota, J. G. Drohan, Yasuo Doi, M. Heldmann, Vlastimil Kus, Andrea Messina, Aidan Robson, J. Dodd, Veronique Boisvert, Francis Anghinolfi, Kerim Suruliz, D. P. Benjamin, T. Yamazaki, Yo K. Zalite, Monika Wielers, S. Klous, Lj Simic, Adam Edward Barton, M. Plamondon, Eric Lancon, E. Musto, Michael Ernst, Raphael Vuillermet, Claudia Glasman, A. Kootz, K. Stoerig, E. K. U. Gross, Göran Jarlskog, A. Koutsman, M. Fehling-Kaschek, A. M. Moisseev, M. Legendre, Z. L. Ren, J. Labbe, A. T. Waugh, Claudia Gemme, Michel Janus, D. Errede, James Monk, Chikara Fukunaga, J. Sodomka, N. Sasao, S. R. Whitehead, Fares Djama, M. Trottier-McDonald, M. Volpi, Stanley Lai, R. Meera-Lebbai, Cristina Galea, S. Zimmermann, Karsten Köneke, E. von Toerne, M. Mathes, Rachid Mazini, Evelyn Thomson, M. Aharrouche, Johannes Elmsheuser, F. J. Tique Aires Viegas, Sanda Dita, Yao Ming, M. Gosselink, Allison McCarn, Giacinto Piacquadio, Mohamed Ouchrif, Manuela Campanelli, John Hill, M. Rammensee, Jahred Adelman, S. Meuser, Peter Fischer, Ludovico Pontecorvo, N. Amram, Alexander Cheplakov, S. P. Baranov, Paul Hodgson, F. Kohn, Silvia Franchino, John Hart, Joleen Pater, L. Nodulman, D. C. Bailey, A. Eppig, J. Pina, Irena Nikolic-Audit, G. Otero y Garzon, Marc Escalier, F. K. Martens, James Ferrando, J. Wotschack, T. Nyman, N. Khovanskiy, J. Ocariz, W. G. Scott, Sergey Peleganchuk, A. Klier, Ioulian Budagov, Yoshiji Yasu, Ivan Peric, Christian Ohm, E. Jansen, Jean-Baptiste Sauvan, M. Karagoz, N. van Eldik, O. Peters, Z. Czyczula, H. Garitaonandia, Igor Potrap, A. De Santo, J. Kennedy, C. Bohm, S. R. Armstrong, V. Gilewsky, G. Negri, A. Andreazza, Yoram Rozen, F. Luehring, P. Perrodo, M. C. N. Fiolhais, Georges Aad, G. Blanchot, K. Nikolaev, S. R. Hou, S. Errede, W. Ehrenfeld, Valerio Vercesi, M. Keil, Mossadek Talby, Evgenia Panagiotopoulou, J. Zhong, Sau Lan Wu, Kaushik De, F. Podlyski, Michele Bianco, S. Arfaoui, A. W. Phillips, A. Marin, Jonathan Butterworth, S. Franz, K. Karr, R. Apolle, Makoto Tomoto, W. Park, David H. Adams, Alexander Khodinov, Pavlos Ioannou, Martin White, Eric Feng, C. Schwanenberger, António Amorim, Oleg Solovyanov, A. Manz, Kristof Schmieden, Lucia Masetti, F. Spila, A. Camard, N. Triplett, J. Therhaag, Stephen Hillier, C. Oropeza Barrera, X. C. Lou, Luis Hervas, D. Boscherini, N. Möser, G. Susinno, Georgios Iakovidis, Sergey Chekulaev, Will Davey, J. D. Palmer, Mikhail Demichev, Z. V. Krumshteyn, Kohei Yorita, A. Meade, H. Wellenstein, Andrea Negri, J. Morin, W. J. Murray, H. Hakobyan, P. Weber, A. Pacheco Pages, T. Holy, Boris Panes, C. Collins-Tooth, Antonio Ferrer, E. Piccaro, A. A. Nepomuceno, F. Orellana, Rustem Ospanov, Hongbo Zhu, I. V. Gorelov, Carmen Maidantchik, A. Astvatsatourov, Brinick Simmons, Louise Heelan, C. N. P. Gee, Kamil Augsten, M. A. Houlden, A. M. Henriques Correia, A. M. Rahimi, Stefano Giagu, O. Le Dortz, Eduard Kladiva, Andree Robichaud-Veronneau, S. J. Wheeler-Ellis, S. Rolli, Serban Protopopescu, Igor Boyko, A. Vitale, M. Dehchar, S. Ferrag, Francois Vazeille, A. Trivedi, D. Reljic, J. Flammer, Daniel Froidevaux, Z. Kohout, S. Bordoni, M. Fokitis, M. Lewandowska, Gregor Kramberger, D. Short, Varlen Grabski, Peter Steinberg, P. Nevski, Saverio D'Auria, Anatoli Romaniouk, Horst Severini, A. Korn, E. Arik, Oliver Stelzer-Chilton, Mohsen Khakzad, E. Chareyre, L. Magnoni, Sergey Panitkin, Todd Brian Huffman, K. A. Johns, S. Psoroulas, M. Wen, A. Farilla, Pedro Teixeira-Dias, Filipe Veloso, Nenad Vranjes, T. Bain, J. C.L. Tseng, Ping-Kun Teng, A. Pinder, A. Onofre, Jan Stark, N. Bousson, M. L. Ferrer, James Mueller, Junichi Tanaka, Peter Bussey, T. Gadfort, G. P. Kirsch, S. Böser, Malik Aliev, C. Kummer, Susumu Terada, Vladimir Smakhtin, Andreas Kugel, Craig Wiglesworth, Andy Haas, F. Vives Vaque, B. Di Girolamo, Luis March, E. Mazzoni, M. Nash, Olga Igonkina, Mariagrazia Alviggi, A. Gibson, X. R. Chen, S. Brunet, Teresa Lenz, C. Joram, H. Przysiezniak, Henry Lubatti, Raquel Pezoa, Yasuhiro Homma, Andreas Wildauer, V. M. Malyshev, Zach Marshall, Philipp Fleischmann, Alden Stradling, Ph Martin, Tobias Flick, R. Coura Torres, H. Nilsen, Y. Unno, P. Adragna, James Walder, T. Dubbs, Vadim Bednyakov, M. Yamada, O. Runolfsson, Ryuichi Takashima, James Jackson, Dong Liu, Sune Jakobsen, B. Zilka, Jessica Metcalfe, Johann Collot, Alan Watson, R. Asfandiyarov, Silvia Resconi, Tim Adye, Genevieve Steele, A. R. Weidberg, N. Tannoury, P. A. Bruckman de Renstrom, J. M. Tuggle, F. Rauscher, P. Skubic, Gabriel Alexandru Popeneciu, E. Nebot, C. Ketterer, J. Purdham, Reinhard Schwienhorst, M. Zdrazil, Val O'Shea, D. Chakraborty, Bjørn Hallvard Samset, R. D. Kass, Dominik Derendarz, A. E. Nuncio-Quiroz, P. C. Kim, J. Deng, Zdenek Hubacek, C. Mora Herrera, L. A.M. Wiik, Marcello Bindi, F. Gianotti, Marcel Vos, Y. Bai, R. Bartoldus, P. Hurst, D. Eriksson, A. Zaytsev, Ryan Reece, S. Albrand, A. C. Schaffer, Hubert Kroha, O. Gabizon, P. Barrillon, J. Lundberg, T. T. Voss, G. Comune, Richard Mount, George Redlinger, S. Cheng, G. D. Kekelidze, Z. Drásal, Matthew Fisher, J. G. Loken, I. D. Manjavidze, Carsten Meyer, F. F. Martin, Hong Ma, Cheng Guang Zhu, S. L. Cheung, Petr Tas, S. H. Oh, Farkhad Khalil-zada, D. Hayden, B. Van Eijk, Laura Gonella, Alan Poppleton, D. Ventura, Stefano Veneziano, H. O. Ogren, L. Courneyea, Paul Hanke, M. Barisonzi, Hermann Kolanoski, Claus Gössling, Benedetto Gorini, Matthias Schott, M. Pohl, S. Jin, P. Gagnon, Daniel Turecek, P. M. Mockett, Xiaowen Lei, A. B. Lazarev, A. Schreiner, J. W. Dawson, C. Haber, Junichi Kanzaki, P. Jež, Joao Seixas, C. N. Booth, Zhonghua Qin, Anthony Keith Morley, Peter Wagner, F. Ahles, L. Mendoza Navas, Jozsef Toth, Elena Korolkova, R. de Asmundis, Marek Tasevsky, Els Koffeman, Diana Scannicchio, Erich Varnes, Li Yuan, R. K. Daya, David Lynn, C. Maiani, Richard Keeler, A. Lavorato, P. Savva, S. P. Mc Kee, L. E. Price, Laura Perini, Masahiro Ikeno, U. Bitenc, Oleg Zenin, J. Rothberg, Livio Mapelli, Goetz Gaycken, O. Silbert, P. Bernat, Andrea Dell'Acqua, N. Delruelle, Alessandra Forti, Xiangyang Ju, M. Hurwitz, A. Misiejuk, M. L. Gonzalez Silva, N. Hill, Katarina Pajchel, Stavros Maltezos, Vakhtang Kartvelishvili, Tim Jones, Bernd Stelzer, G. Baccaglioni, Horst Oberlack, R. J. Sobie, Gianfranco Morello, Hasko Stenzel, H. Han, Serhat Istin, Giuseppe Mornacchi, Joao Saraiva, Josu Cantero, A. Oyarzun, H. Lee, Luc Goossens, B. R. Mellado Garcia, Stefanos Leontsinis, Daniela Rebuzzi, K. M. Chan, N. B. Sinev, J-Y. Hostachy, Itsuo Nakano, Joost Vossebeld, Tadeusz Kowalski, R. Caloi, Wainer Vandelli, Harald Fox, Juan Fuster, B. Wrona, F. Henry-Couannier, David Howell, Pa. Malecki, Moritz Bunse, Claude Leroy, S. Mohrdieck-Möck, Lashkar Kashif, Edward May, J. R. Bensinger, Sophio Pataraia, J. Koll, Sabine Elles, J. D. Hansen, Fairouz Malek, R. Crupi, B. Abi, T. K. Nelson, Vassili Kazanin, Ivana Hristova, Edisher Tskhadadze, P. Gerlach, Iro Koletsou, O. Scallon, Giovanni Siragusa, Henri Bachacou, K. F. Loureiro, C. Arnault, Leonardo Carminati, N. Kerschen, S. Moed, Alexander Lincoln Read, Jessica Levêque, K. Bos, C. Omachi, V. R. Lacuesta, Luiz Caloba, Henric George Wilkens, Thomas Trefzger, Elliot Hughes, Daniel Scheirich, B. Mohn, Th D. Papadopoulou, A. Wilson, T. Cornelissen, C. Cuenca Almenar, J. G. Cogan, D. Capriotti, G. Zevi della Porta, Hans-Christian Schultz-Coulon, James Shank, Christian Weiser, Paolo Laurelli, K. Suita, Barbara Liberti, M. Pecsy, Jemal Khubua, Stephen Watts, Franz E. Bauer, Flera Rizatdinova, T. Sugimoto, John Derek Chapman, W. Kozanecki, S. O. Holmgren, P. G. Bright-Thomas, Martin Goebel, Katsuo Tokushuku, J. Sondericker, E. Brodet, S. Patricelli, T. O. Niinikoski, R. Zitoun, Marcella Capua, E. Rauter, Y. Suzuki, E. Segura, Marc Dobson, Andreas Battaglia, S. Johnert, J. L. Lane, Stephen Burke, S. Sushkov, Giorgi Arabidze, Philip Phillips, Samuel Silverstein, E. Graziani, Ilya Tsukerman, Guenter Duckeck, Michael Flowerdew, Reyhaneh Rezvani, M. Gruwe, H. H. Williams, Antonio Policicchio, D. Sherman, E. van der Kraaij, Sharka Todorova-Nova, T. Sasaki, S. Youssef, Christoph Posch, A. D. Hershenhorn, J. P. Dauvergne, M. Aleppo, C. Biscarat, K. K. Gan, Brian Petersen, Juan Antonio Aguilar-Saavedra, Tamar Djobava, W. H. Bell, L. Di Ciaccio, A. Zsenei, Benjamin Wynne, A. De Salvo, Steinar Stapnes, R. Ueno, L. P. Says, Koji Terashi, Jongmin Lee, A. Antonaki, M. Raas, Craig Buttar, A. P. Vorobiev, R. Bernhard, B. Lundberg, M. Olcese, S. Montesano, D. Greenfield, Michele Livan, Annick Lleres, J. Grognuz, Abbas Kenan Ciftci, Karlheinz Meier, Rui Wang, Josh Moss, Enrique Kajomovitz, C. Handel, J. Almond, J. Nadal, G. Rudolph, M. Schram, Louis Helary, C. Horn, Timothy Barklow, Daria Zieminska, E. Magradze, P. Valente, Andrei Snesarev, J. A. Macana Goia, R. D. Schamberger, C. Lasseur, Ahmimed Ouraou, V. V. Ammosov, Alan Litke, Mieczyslaw Witold Krasny, Yann Coadou, L. K. Gladilin, B. Pinto, Anna Mastroberardino, C. Gong, Bruno Lenzi, T. P. Kokott, Carla Sbarra, Gilbert Poulard, Yuta Takahashi, V. Zutshi, Amanda Cooper-Sarkar, W.J. Willis, S. Schaetzel, Marcin Wladyslaw Wolter, Peter Wienemann, Marek Idzik, D. Rousseau, Nicole Ruckstuhl, O. M. Harris, G. F. Moorhead, Antonio Ereditato, Alexander Grillo, J. E. Sundermann, M. Miñano, Harinder Singh Bawa, Oliver Kortner, C. Zendler, M. Aliyev, Brigitte Vachon, V. Grassi, Peter Sturm, Heather Gray, D. Fortin, O. Pirotte, R. Yoosoofmiya, R. E. Blair, A. Cazzato, A. Kapliy, Riccardo Vari, Jong-Sung Yu, Maria Pilar Casado, G. L. Darlea, W. G. Plano, V. I. Koreshev, J. Walbersloh, K. Benslama, S. Rajek, Robert McPherson, G. L. Glonti, Attila Krasznahorkay, Nicola Semprini-Cesari, H. O. Danielsson, Andrew D. Hamilton, J. Blocki, N. Guttman, T. Cuhadar Donszelmann, R. S. Orr, I. P. Duerdoth, M. V. Gallas, N. J. Cooper-Smith, T. Nishiyama, Igor Gavrilenko, Massimo Lamanna, Y. Gusakov, H. S. Chen, Antonio Limosani, V. O. Tikhomirov, T. Nunnemann, K. Edmonds, R. Di Nardo, Vaclav Vacek, V. Andrei, Dirk Zerwas, Raymond Brock, G. Sauvage, Giovanni Crosetti, Giovanna Bruni, D. R. Hadley, Klaus Mönig, Federica Legger, Valery Khovanskiy, Mihail Chizhov, V. Lombardo, Bruno Mansoulie, Paul Newman, Stanislav Pospisil, Ph. Schune, W-M. Yao, H. Khandanyan, Clara Troncon, Alexei Klimentov, Masaharu Nomachi, Y. Tanaka, B. Stugu, Nigel Hessey, M. Limper, Olga Beltramello, Nicoletta Garelli, J. Yamaoka, Michael R. Wessels, M. Imori, You Zhou, Aranzazu Ruiz-Martinez, Alison Holmes, J. Novakova, P. Zarzhitsky, L. Gauthier, Ricardo Gonçalo, Paul Jackson, G. E. Pospelov, Mihai Ciubancan, V. B. Bobrovnikov, D. A. Forbush, F. Cerutti, Kathryn Grimm, B. Nordkvist, B. D. Cooper, M. Morii, V. Castillo Gimenez, L. Chen, S. H. Kim, A. Renaud, M. Mudrinic, Sergey Kuleshov, M. Nožička, P. Puzo, Yang Gao, Elliott Cheu, T. Henß, G. Jin, A. Bogouch, P. Amaral, Andrea Favareto, M. Gouanère, P. Cwetanski, John Huth, N. Vlasov, M. I. Besana, H. Kiyamura, J. W. Chapman, G. Marchiori, Alexander Khanov, K. Harrison, H. Boterenbrood, H. Kagan, C. D. Cojocaru, A. Siebel, Michael Rijssenbeek, A.S. Vovenko, T. Stockmanns, Gary Boorman, Juan Terron, E. Gornicki, V. J. Guarino, Domizia Orestano, C. Fabre, V. G. Zaets, L. Bugge, Simone Monzani, Avi Gershon, A. Salamon, V. Zhuravlov, J. Coggeshall, Michael Dührssen, K. Tani, F. Georgatos, Richard Bates, C. R. Boddy, V. Juranek, Troels Petersen, S. Dean, K. Kessoku, I. Mussche, N. P. Gollub, S. González de la Hoz, C. Lebel, H. G. Sander, Hans Peter Beck, R. Zimmermann, M. Martinez, J. A. Valls Ferrer, M. L. Kocian, A. V. Pleskach, A. S. Thompson, B. Butler, Thomas Naumann, P. R. Norton, Markus Nordberg, E. Wulf, Dusan Bruncko, Mark Hatch, A. M. Bach, Vakhtang Tsiskaridze, Maria Curatolo, Saminder Dhaliwal, F. Tarrade, G. Akimoto, Riccardo-Maria Bianchi, Paolo Bagnaia, S. Kabana, J. N. Butler, Anyes Taffard, Nuno Anjos, M. Simonyan, A. J. Lankford, D. Prieur, Th. Müller, Joseph Izen, S. Antonelli, John Morris, Antoine Marzin, Juergen Thomas, Nicolas Ellis, Ruslan Mashinistov, Alessandra Ciocio, K. Sliwa, Shinichi Shimizu, L. Han, G. G.G. Massaro, Gen Kawamura, J. Treis, Wim Lavrijsen, Enrico Pasqualucci, V. F. Chepurnov, P. L. Rosendahl, Roberto Ferrari, R. Ishmukhametov, Anna Sfyrla, D. Tardif, Marcella Bona, V. V. Kabachenko, Abdenour Lounis, Ayda Beddall, Nathalie Besson, M. Robinson, Daniel Dobos, A. Cavallari, T. Greenshaw, Andrej Gorišek, Sophie Trincaz-Duvoid, Kazuhiko Hara, T. Frank, C. Dennis, Craig Blocker, A. Barbaro Galtieri, A. Mapelli, Gregor Herten, S. Cabrera Urbán, C. Geweniger, P. K. Mal, D. M. Gingrich, J. Glatzer, Enrico Rossi, H. S. Bansil, R. Calkins, Daniela Salvatore, A. Mayne, I. Orlov, Frank Filthaut, C. Caramarcu, J. Degenhardt, Anne-Isabelle Etienvre, F. Diblen, J. Ferencei, Michael Shupe, L. Lipinsky, G. Alexandre, S. Ventura, Pavel Reznicek, Chiara Meroni, Bruce Yabsley, Deywis Moreno, N. R. Nation, J. Griffiths, M. P. Goulette, Elzbieta Banas, A. Larner, T. Kanno, E. Le Menedeu, Stefan Simion, Serban Constantinescu, Takashi Matsushita, Adele Rimoldi, A. P. Colijn, X. Prudent, S. Kotov, G. A. Cowan, Paul Dervan, L. Köpke, L. V. Kalinovskaya, Darren Price, Fedor Prokoshin, Peter Kluit, R. Caputo, J. E. Pilcher, B. Koblitz, Pierre Savard, Matteo Cavalli-Sforza, T. Hott, Duc Ta, D. Oliveira Damazio, E. E. Kluge, W. Blum, J. Groth-Jensen, V. Gallo, Alevtina Shmeleva, Davide Caforio, Ahmet Bingul, Elzbieta Richter-Was, Michal Marcisovsky, D. R. Rust, Martin Aleksa, Alexandre Lebedev, David Cameron, Shikma Bressler, Regina Moles-Valls, Tomasz Bold, R. M. Barnett, Tiefu Zhao, Jan-Ulf Mjörnmark, J. Siegrist, J. K. Kraus, H. Matsunaga, S. J. Chen, E. Brambilla, Ulrike Blumenschein, M. P. Schmidt, P. Jussel, K. Grybel, L. Capasso, R. Pravahan, A. C. Falou, Robert Stanek, Tadashi Maeno, T. Göttfert, Stéphane Jézéquel, T. Poghosyan, J. Huston, A. N. Karyukhin, J. Idarraga, Daniel Pomarède, Alexey Dudarev, Philippe Grenier, Wladyslaw Dabrowski, Brad Abbott, E. C. Katsoufis, P. M. Manning, Maarten Boonekamp, Andrej Filipcic, Katarzyna Kordas, Lydia Roos, C. Bromberg, P. F. Giraud, Peter Love, C. Osuna, J. Drees, N. D. Topilin, G. Wooden, N. A. McCubbin, K. Pretzl, A. R. Davison, J. Tobias, M. A. L. Leite, R. J. Madaras, Evangelos Gazis, M. R. Jaekel, Y. Jiang, C. Menot, Yoshio Arai, A. A. Korol, Claude Guyot, Sinead Farrington, Georg Zobernig, Yoji Hasegawa, Clemens Lange, W. Lau, S. Hasegawa, M. Seman, G. Lutz, Marco Barbero, M. Rose, Claudia Ciocca, Ketevi Assamagan, M. Thioye, L. Zanello, T. Ehrich, J. R. Carter, Jieh-Wen Tsung, Alessandro Cerri, Philip Bechtle, A. Glazov, H. M. Braun, Hiroyuki Iwasaki, John-Bjarne Hansen, E. Le Guirriec, F. Vannucci, Clement Helsens, B. Demirkoz, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), APC - Neutrinos, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institute of High Energy Physics (IHEP), Chinese Academy of Sciences [Changchun Branch] (CAS), ATLAS, Aad, G, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Cevenini, Francesco, Chiefari, Giovanni, DELLA VOLPE, Domenico, Merola, Leonardo, Patricelli, Sergio, Conventi, F., DELLA PIETRA, Massimo, Giordano, Raffaele, Musto, E., Rossi, E., Sanchez, A., Carlino, G., de Asmundis, R., Doria, A., Iengo, P., Izzo, V., Sekhniaidze, G., ATLAS (IHEF, IoP, FNWI), Abbott, B, Abdallah, J, Abdelalim, Aa, Abdesselam, A, Abdinov, O, Abi, B, Abolins, M, Abramowicz, H, Abreu, H, Acerbi, E, Acharya, B, Ackers, M, Adams, Dl, Addy, Tn, Adelman, J, Aderholz, M, Adomeit, S, Adragna, P, Adye, T, Aefsky, S, Aguilar Saavedra, Ja, Aharrouche, M, Ahlen, Sp, Ahles, F, Ahmad, A, Ahsan, M, Aielli, G, Akdogan, T, Akesson, Tpa, Akimoto, G, Akimov, Av, Alam, M, Alam, Ma, Albrand, S, Aleksa, M, Aleksandrov, In, Aleppo, M, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Aliev, M, Alimonti, G, Alison, J, Aliyev, M, Allport, Pp, Allwood Spiers, Se, Almond, J, Aloisio, A, Alon, R, Alonso, A, Alonso, J, Alviggi, Mg, Amako, K, Amaral, P, Amelung, C, Ammosov, Vv, Amorim, A, Amoros, G, Amram, N, Anastopoulos, C, Andeen, T, Anders, Cf, Anderson, Kj, Andreazza, A, Andrei, V, Andrieux, Ml, Anduaga, X, Angerami, A, Anghinolfi, F, Anjos, N, Annovi, A, Antonaki, A, Antonelli, M, Antonelli, S, Antos, J, Anulli, F, Aoun, S, Bella, La, Apolle, R, Arabidze, G, Aracena, I, Arai, Y, Arce, Ath, Archambault, Jp, Arfaoui, S, Arguin, Jf, Arik, E, Arik, M, Armbruster, Aj, Arms, Ke, Armstrong, Sr, Arnaez, O, Arnault, C, Artamonov, A, Artoni, G, Arutinov, D, Asai, S, Asfandiyarov, R, Ask, S, Asman, B, Asquith, L, Assamagan, K, Astbury, A, Astvatsatourov, A, Atoian, G, Aubert, B, Auerbach, B, Auge, E, Augsten, K, Aurousseau, M, Austin, N, Avramidou, R, Axen, D, Ay, C, Azuelos, G, Azuma, Y, Baak, Ma, Baccaglioni, G, Bacci, C, Bach, Am, Bachacou, H, Bachas, K, Bachy, G, Backes, M, Badescu, E, Bagnaia, P, Bahinipati, S, Bai, Y, Bailey, Dc, Bain, T, Baines, Jt, Baker, Ok, Baker, S, Pedrosa, Fbd, Banas, E, Banerjee, P, Banerjee, S, Banfi, D, Bangert, A, Bansal, V, Bansil, H, Barak, L, Baranov, Sp, Barashkou, A, Galtieri, Ab, Barber, T, Barberio, El, Barberis, D, Barbero, M, Bardin, Dy, Barillari, T, Barisonzi, M, Barklow, T, Barlow, N, Barnett, Bm, Barnett, Rm, Baroncelli, A, Barr, Aj, Barreiro, F, da Costa, Jbg, Barrillon, P, Bartoldus, R, Barton, Ae, Bartsch, D, Bates, Rl, Batkova, L, Batley, Jr, Battaglia, A, Battistin, M, Battistoni, G, Bauer, F, Bawa, H, Beare, B, Beau, T, Beauchemin, Ph, Beccherle, R, Bechtle, P, Beck, Hp, Beckingham, M, Becks, Kh, Beddall, Aj, Beddall, A, Bednyakov, Va, Bee, C, Begel, M, Harpaz, Sb, Behera, Pk, Beimforde, M, Belanger Champagne, C, Bell, Pj, Bell, Wh, Bella, G, Bellagamba, L, Bellina, F, Bellomo, G, Bellomo, M, Belloni, A, Belotskiy, K, Beltramello, O, Ben Ami, S, Benary, O, Benchekroun, D, Benchouk, C, Bendel, M, Benedict, Bh, Benekos, N, Benhammou, Y, Benjamin, Dp, Benoit, M, Bensinger, Jr, Benslama, K, Bentvelsen, S, Berge, D, Kuutmann, Eb, Berger, N, Berghaus, F, Berglund, E, Beringer, J, Bernardet, K, Bernat, P, Bernhard, R, Bernius, C, Berry, T, Bertin, A, Bertinelli, F, Bertolucci, F, Besana, Mi, Besson, N, Bethke, S, Bhimji, W, Bianchi, Rm, Bianco, M, Biebel, O, Biesiada, J, Biglietti, M, Bilokon, H, Bindi, M, Bingul, A, Bini, C, Biscarat, C, Bitenc, U, Black, Km, Blair, Re, Blanchard, Jb, Blanchot, G, Blocker, C, Blocki, J, Blondel, A, Blum, W, Blumenschein, U, Bobbink, Gj, Bobrovnikov, Vb, Bocci, A, Bock, R, Boddy, Cr, Boehler, M, Boek, J, Boelaert, N, Boser, S, Bogaerts, Ja, Bogdanchikov, A, Bogouch, A, Bohm, C, Boisvert, V, Bold, T, Boldea, V, Bona, M, Boonekamp, M, Boorman, G, Booth, Cn, Booth, P, Booth, Jra, Bordoni, S, Borer, C, Borisov, A, Borissov, G, Borjanovic, I, Borroni, S, Bos, K, Boscherini, D, Bosman, M, Boterenbrood, H, Botterill, D, Bouchami, J, Boudreau, J, Bouhova Thacker, Ev, Boulahouache, C, Bourdarios, C, Bousson, N, Boveia, A, Boyd, J, Boyko, Ir, Bozhko, Ni, Bozovic Jelisavcic, I, Bracinik, J, Braem, A, Brambilla, E, Branchini, P, Brandenburg, Gw, Brandt, A, Brandt, G, Brandt, O, Bratzler, U, Brau, B, Brau, Je, Braun, Hm, Brelier, B, Bremer, J, Brenner, R, Bressler, S, Breton, D, Brett, Nd, Bright Thomas, Pg, Britton, D, Brochu, Fm, Brock, I, Brock, R, Brodbeck, Tj, Brodet, E, Broggi, F, Bromberg, C, Brooijmans, G, Brooks, Wk, Brown, G, Brubaker, E, de Renstrom, Pab, Bruncko, D, Bruneliere, R, Brunet, S, Bruni, A, Bruni, G, Bruschi, M, Buanes, T, Bucci, F, Buchanan, J, Buchanan, Nj, Buchholz, P, Buckingham, Rm, Buckley, Ag, Buda, Si, Budagov, Ia, Budick, B, Buscher, V, Bugge, L, Buira Clark, D, Buis, Ej, Bulekov, O, Bunse, M, Buran, T, Burckhart, H, Burdin, S, Burgess, T, Burke, S, Busato, E, Bussey, P, Buszello, Cp, Butin, F, Butler, B, Butler, Jm, Buttar, Cm, Butterworth, Jm, Buttinger, W, Byatt, T, Urban, Sc, Caccia, M, Caforio, D, Cakir, O, Calafiura, P, Calderini, G, Calfayan, P, Calkins, R, Caloba, Lp, Caloi, R, Calvet, D, Calvet, S, Camard, A, Camarri, P, Cambiaghi, M, Cameron, D, Cammin, J, Campana, S, Campanelli, M, Canale, V, Canelli, F, Canepa, A, Cantero, J, Capasso, L, Garrido, Mdmc, Caprini, I, Caprini, M, Capriotti, D, Capua, M, Caputo, R, Caramarcu, C, Cardarelli, R, Carli, T, Carlino, G, Carminati, L, Caron, B, Caron, S, Carpentieri, C, Montoya, Gdc, Montero, Sc, Carter, Aa, Carter, Jr, Carvalho, J, Casadei, D, Casado, Mp, Cascella, M, Caso, C, Hernandez, Amc, Castaneda Miranda, E, Gimenez, Vc, Castro, Nf, Cataldi, G, Cataneo, F, Catinaccio, A, Catmore, Jr, Cattai, A, Cattani, G, Caughron, S, Cavallari, A, Cavalleri, P, Cavalli, D, Cavalli Sforza, M, Cavasinni, V, Cazzato, A, Ceradini, Filippo, Cerna, C, Cerqueira, A, Cerri, A, Cerrito, L, Cerutti, F, Cetin, Sa, Cevenini, F, Chafaq, A, Chakraborty, D, Chan, K, Chapleau, B, Chapman, Jd, Chapman, Jw, Chareyre, E, Charlton, Dg, Chavda, V, Cheatham, S, Chekanov, S, Chekulaev, Sv, Chelkov, Ga, Chen, H, Chen, L, Chen, S, Chen, T, Chen, X, Cheng, S, Cheplakov, A, Chepurnov, Vf, El Moursli, Rc, Chernyatin, V, Cheu, E, Cheung, Sl, Chevalier, L, Chevallier, F, Chiefari, G, Chikovani, L, Childers, Jt, Chilingarov, A, Chiodini, G, Chizhov, Mv, Choudalakis, G, Chouridou, S, Christidi, Ia, Christov, A, Chromek Burckhart, D, Chu, Ml, Chudoba, J, Ciapetti, G, Ciftci, Ak, Ciftci, R, Cinca, D, Cindro, V, Ciobotaru, Md, Ciocca, C, Ciocio, A, Cirilli, M, Ciubancan, M, Clark, A, Clark, Pj, Cleland, W, Clemens, Jc, Clement, B, Clement, C, Clifft, Rw, Coadou, Y, Cobal, M, Coccaro, A, Cochran, J, Coe, P, Cogan, Jg, Coggeshall, J, Cogneras, E, Cojocaru, Cd, Colas, J, Colijn, Ap, Collard, C, Collins, Nj, Collins Tooth, C, Collot, J, Colon, G, Coluccia, R, Comune, G, Muino, Pc, Coniavitis, E, Conidi, Mc, Consonni, M, Constantinescu, S, Conta, C, Conventi, F, Cook, J, Cooke, M, Cooper, Bd, Cooper Sarkar, Am, Cooper Smith, Nj, Copic, K, Cornelissen, T, Corradi, M, Correard, S, Corriveau, F, Cortes Gonzalez, A, Cortiana, G, Costa, G, Costa, Mj, Costanzo, D, Costin, T, Cote, D, Torres, Rc, Courneyea, L, Cowan, G, Cowden, C, Cox, Be, Cranmer, K, Cristinziani, M, Crosetti, G, Crupi, R, Crepe Renaudin, S, Almenar, Cc, Donszelmann, Tc, Cuneo, S, Curatolo, M, Curtis, Cj, Cwetanski, P, Czirr, H, Czyczula, Z, D'Auria, S, D'Onofrio, M, D'Orazio, A, Mello, Adg, Da Silva, Pvm, Da Via, C, Dabrowski, W, Dahlhoff, A, Dai, T, Dallapiccola, C, Dallison, Sj, Dam, M, Dameri, M, Damiani, D, Danielsson, Ho, Dankers, R, Dannheim, D, Dao, V, Darbo, G, Darlea, Gl, Daum, C, Dauvergne, Jp, Davey, W, Davidek, T, Davidson, N, Davidson, R, Davies, M, Davison, Ar, Dawe, E, Dawson, I, Dawson, Jw, Daya, Rk, De, K, de Asmundis, R, De Castro, S, De Cecco, S, de Graat, J, De Groot, N, de Jong, P, De La Cruz Burelo, E, De La Taille, C, De Lotto, B, De Mora, L, De Nooij, L, Branco, Mdo, De Pedis, D, de Saintignon, P, De Salvo, A, De Sanctis, U, De Santo, A, De Regie, Jbdv, Dean, S, Dedes, G, Dedovich, Dv, Degenhardt, J, Dehchar, M, Deile, M, Del Papa, C, Del Peso, J, Del Prete, T, Dell'Acqua, A, Dell'Asta, L, Della Pietra, M, della Volpe, D, Delmastro, M, Delpierre, P, Delruelle, N, Delsart, Pa, Deluca, C, Demers, S, Demichev, M, Demirkoz, B, Deng, J, Denisov, Sp, Dennis, C, Derendarz, D, Derkaoui, Je, Derue, F, Dervan, P, Desch, K, Devetak, E, Deviveiros, Po, Dewhurst, A, Dewilde, B, Dhaliwal, S, Dhullipudi, R, Di Ciaccio, A, Di Ciaccio, L, Di Girolamo, A, Di Girolamo, B, Di Luise, S, Di Mattia, A, Di Nardo, R, Di Simone, A, Di Sipio, R, Diaz, Ma, Diblen, F, Diehl, Eb, Dietl, H, Dietrich, J, Dietzsch, Ta, Diglio, S, Yagci, Kd, Dingfelder, J, Dionisi, C, Dita, P, Dita, S, Dittus, F, Djama, F, Djilkibaev, R, Djobava, T, do Vale, Mab, Wemans, Adv, Doan, Tko, Dobbs, M, Dobinson, R, Dobos, D, Dobson, E, Dobson, M, Dodd, J, Dogan, Ob, Doglioni, C, Doherty, T, Doi, Y, Dolejsi, J, Dolenc, I, Dolezal, Z, Dolgoshein, Ba, Dohmae, T, Donadelli, M, Donega, M, Donini, J, Dopke, J, Doria, A, Dos Anjos, A, Dosil, M, Dotti, A, Dova, Mt, Dowell, Jd, Doxiadis, Ad, Doyle, At, Drasal, Z, Drees, J, Dressnandt, N, Drevermann, H, Driouichi, C, Dris, M, Drohan, Jg, Dubbert, J, Dubbs, T, Dube, S, Duchovni, E, Duckeck, G, Dudarev, A, Dudziak, F, Duhrssen, M, Duerdoth, Ip, Duflot, L, Dufour, Ma, Dunford, M, Yildiz, Hd, Duxfield, R, Dwuznik, M, Dydak, F, Dzahini, D, Duren, M, Ebke, J, Eckert, S, Eckweiler, S, Edmonds, K, Edwards, Ca, Efthymiopoulos, I, Ehrenfeld, W, Ehrich, T, Eifert, T, Eigen, G, Einsweiler, K, Eisenhandler, E, Ekelof, T, El Kacimi, M, Ellert, M, Elles, S, Ellinghaus, F, Ellis, K, Ellis, N, Elmsheuser, J, Elsing, M, Ely, R, Emeliyanov, D, Engelmann, R, Engl, A, Epp, B, Eppig, A, Erdmann, J, Ereditato, A, Eriksson, D, Ernst, J, Ernst, M, Ernwein, J, Errede, D, Errede, S, Ertel, E, Escalier, M, Escobar, C, Curull, Xe, Esposito, B, Etienne, F, Etienvre, Ai, Etzion, E, Evangelakou, D, Evans, H, Fabbri, L, Fabre, C, Facius, K, Fakhrutdinov, Rm, Falciano, S, Falou, Ac, Fang, Y, Fanti, M, Farbin, A, Farilla, A, Farley, J, Farooque, T, Farrington, Sm, Farthouat, P, Fasching, D, Fassnacht, P, Fassouliotis, D, Fatholahzadeh, B, Favareto, A, Fayard, L, Fazio, S, Febbraro, R, Federic, P, Fedin, Ol, Fedorko, I, Fedorko, W, Fehling Kaschek, M, Feligioni, L, Fellmann, D, Felzmann, Cu, Feng, C, Feng, Ej, Fenyuk, Ab, Ferencei, J, Ferguson, D, Ferland, J, Fernandes, B, Fernando, W, Ferrag, S, Ferrando, J, Ferrara, V, Ferrari, A, Ferrari, P, Ferrari, R, Ferrer, A, Ferrer, Ml, Ferrere, D, Ferretti, C, Parodi, Af, Fiascaris, M, Fiedler, F, Filipcic, A, Filippas, A, Filthaut, F, Fincke Keeler, M, Fiolhais, Mcn, Fiorini, L, Firan, A, Fischer, G, Fischer, P, Fisher, Mj, Fisher, Sm, Flammer, J, Flechl, M, Fleck, I, Fleckner, J, Fleischmann, P, Fleischmann, S, Flick, T, Castillo, Lrf, Flowerdew, Mj, Fohlisch, F, Fokitis, M, Martin, Tf, Forbush, Da, Formica, A, Forti, A, Fortin, D, Foster, Jm, Fournier, D, Foussat, A, Fowler, Aj, Fowler, K, Fox, H, Francavilla, P, Franchino, S, Francis, D, Frank, T, Franklin, M, Franz, S, Fraternali, M, Fratina, S, French, St, Froeschl, R, Froidevaux, D, Frost, Ja, Fukunaga, C, Torregrosa, Ef, Fuster, J, Gabaldon, C, Gabizon, O, Gadfort, T, Gadomski, S, Gagliardi, G, Gagnon, P, Galea, C, Gallas, Ej, Gallas, Mv, Gallo, V, Gallop, Bj, Gallus, P, Galyaev, E, Gan, Kk, Gao, Y, Gapienko, Va, Gaponenko, A, Garberson, F, Garcia Sciveres, M, Garcia, C, Navarro, Jeg, Gardner, Rw, Garelli, N, Garitaonandia, H, Garonne, V, Garvey, J, Gatti, C, Gaudio, G, Gaumer, O, Gaur, B, Gauthier, L, Gavrilenko, Il, Gay, C, Gaycken, G, Gayde, Jc, Gazis, En, Ge, P, Gee, Cnp, Geich Gimbel, C, Gellerstedt, K, Gemme, C, Gemmell, A, Genest, Mh, Gentile, S, Georgatos, F, George, S, Gerlach, P, Gershon, A, Geweniger, C, Ghazlane, H, Ghez, P, Ghodbane, N, Giacobbe, B, Giagu, S, Giakoumopoulou, V, Giangiobbe, V, Gianotti, F, Gibbard, B, Gibson, A, Gibson, Sm, Gieraltowski, Gf, Gilbert, Lm, Gilchriese, M, Gildemeister, O, Gilewsky, V, Gillberg, D, Gillman, Ar, Gingrich, Dm, Ginzburg, J, Giokaris, N, Giordano, R, Giorgi, Fm, Giovannini, P, Giraud, Pf, Giugni, D, Giusti, P, Gjelsten, Bk, Gladilin, Lk, Glasman, C, Glatzer, J, Glazov, A, Glitza, Kw, Glonti, Gl, Godfrey, J, Godlewski, J, Goebel, M, Gopfert, T, Goeringer, C, Gossling, C, Gottfert, T, Goldfarb, S, Goldin, D, Golling, T, Gollub, Np, Golovnia, Sn, Gomes, A, Fajardo, Lsg, Goncalo, R, Gonella, L, Gong, C, Gonidec, A, Gonzalez, S, de la Hoz, Sg, Silva, Mlg, Gonzalez Sevilla, S, Goodson, Jj, Goossens, L, Gorbounov, Pa, Gordon, Ha, Gorelov, I, Gorfine, G, Gorini, B, Gorini, E, Gorisek, A, Gornicki, E, Gorokhov, Sa, Gorski, Bt, Goryachev, Vn, Gosdzik, B, Gosselink, M, Gostkin, Mi, Gouanere, M, Eschrich, Ig, Gouighri, M, Goujdami, D, Goulette, Mp, Goussiou, Ag, Goy, C, Grabowska Bold, I, Grabski, V, Grafstrom, P, Grah, C, Grahn, Kj, Grancagnolo, F, Grancagnolo, S, Grassi, V, Gratchev, V, Grau, N, Gray, Hm, Gray, Ja, Graziani, E, Grebenyuk, Og, Greenfield, D, Greenshaw, T, Greenwood, Zd, Gregor, Im, Grenier, P, Griesmayer, E, Griffiths, J, Grigalashvili, N, Grillo, Aa, Grimm, K, Grinstein, S, Gris, Ply, Grishkevich, Yv, Grivaz, Jf, Grognuz, J, Groh, M, Gross, E, Grosse Knetter, J, Groth Jensen, J, Gruwe, M, Grybel, K, Guarino, Vj, Guicheney, C, Guida, A, Guillemin, T, Guindon, S, Guler, H, Gunther, J, Guo, B, Guo, J, Gupta, A, Gusakov, Y, Gushchin, Vn, Gutierrez, A, Gutierrez, P, Guttman, N, Gutzwiller, O, Guyot, C, Gwenlan, C, Gwilliam, Cb, Haas, A, Haas, S, Haber, C, Hackenburg, R, Hadavand, Hk, Hadley, Dr, Haefner, P, Hahn, F, Haider, S, Hajduk, Z, Hakobyan, H, Haller, J, Hamacher, K, Hamilton, A, Hamilton, S, Han, H, Han, L, Hanagaki, K, Hance, M, Handel, C, Hanke, P, Hansen, Cj, Hansen, Jr, Hansen, Jb, Hansen, Jd, Hansen, Ph, Hansson, P, Hara, K, Hare, Ga, Harenberg, T, 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Wildt, I. Wilhelm, H. G. Wilkens, J. Z. Will, E. Williams, H. H. Williams, W. Willis, S. Willocq, J. A. Wilson, M. G. Wilson, A. Wilson, I. Wingerter-Seez, S. Winkelmann, F. Winklmeier, M. Wittgen, M. W. Wolter, H. Wolters, G. Wooden, B. K. Wosiek, J. Wotschack, M. J. Woudstra, K. Wraight, C. Wright, B. Wrona, S. L. Wu, X. Wu, Y. Wu, E. Wulf, R. Wunstorf, B. M. Wynne, L. Xaplanteris, S. Xella, S. Xie, Y. Xie, C. Xu, D. Xu, G. Xu, B. Yabsley, M. Yamada, A. Yamamoto, K. Yamamoto, S. Yamamoto, T. Yamamura, J. Yamaoka, T. Yamazaki, Y. Yamazaki, Z. Yan, H. Yang, U. K. Yang, Y. Yang, Y. Yang, Z. Yang, S. Yanush, W-M. Yao, Y. Yao, Y. Yasu, J. Ye, S. Ye, M. Yilmaz, R. Yoosoofmiya, K. Yorita, R. Yoshida, C. Young, S. Youssef, D. Yu, J. Yu, J. Yu, L. Yuan, A. Yurkewicz, V. G. Zaets, R. Zaidan, A. M. Zaitsev, Z. Zajacova, Yo.K. Zalite, L. Zanello, P. Zarzhitsky, A. Zaytsev, M. Zdrazil, C. Zeitnitz, M. Zeller, P. F. Zema, A. Zemla, C. Zendler, A. V. Zenin, O. Zenin, T. Ženiš, Z. Zenonos, S. Zenz, D. Zerwas, G. Zevi della Porta, Z. Zhan, D. Zhang, H. Zhang, J. Zhang, X. Zhang, Z. Zhang, L. Zhao, T. Zhao, Z. Zhao, A. Zhemchugov, S. Zheng, J. Zhong, B. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. Zhu, Y. Zhu, X. Zhuang, V. Zhuravlov, D. Zieminska, B. Zilka, R. Zimmermann, S. Zimmermann, S. Zimmermann, M. Ziolkowski, R. Zitoun, L. Živković, V. V. Zmouchko, G. Zobernig, A. Zoccoli, Y. Zolnierowski, A. Zsenei, M. zur Nedden, V. Zutshi, L. Zwalinski, Doğuş Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, TR3959, Çetin, Serkant Ali, G., Aad, Bianco, Michele, G., Chiodini, M. R., Coluccia, Gorini, Edoardo, Primavera, Margherita, Spagnolo, Stefania Antonia, Ventura, Andrea, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), UAM. Departamento de Física Teórica, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universidade do Minho, Abdelalim Aly, Ahmed Aly, Alexandre, Gauthier, Backes, Moritz, Bell, Paul, Bell, William, Berglund, Frida Elina, Blondel, Alain, Bucci, Francesca, Clark, Allan Geoffrey, Dao, Valerio, Efthymiopoulos, Ilias, Ferrere, Didier, Gadomski, Szymon, Garcia Navarro, Jose Enrique, Gaumer, Olivier, Gonzalez Sevilla, Sergio, Goulette, Marc, Hamilton, Andrew, Leger, Annie, Lister, Alison, Macina-Buono, Daniela, Martin Dit Latour, Bertrand, Mikulec, Bettina, Moneta, Lorenzo, Mora Herrera, Maria Clemencia Rosario, Morone, Maria Cristina, Nektarijevic, Snezana, Orellana, Frédérik, Pasztor, Arpad, Pohl, Martin, Robichaud-Veronneau, Andrée, Rosselet, Laurent, Urquijo, Phillip, Wu, Xin, and ATLAS Collaboration (ukupan broj autora: 3048)
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Particle physics ,MISSING TRANSVERSE ENERGY ,Ciências Naturais::Ciências Físicas ,Atlas detector ,Ciências Físicas [Ciências Naturais] ,FIS/04 - Fisica Nucleare e Subnucleare ,General Physics and Astronomy ,FOS: Physical sciences ,transverse energy: missing-energy ,ATLAS ,universal extra dimension ,compactification ,CERN LHC Coll ,background ,p p: interaction ,final state: two-photon ,photon: Kaluza-Klein ,electroweak interaction: standard model: validity test ,experimental results ,7000 GeV-cms ,ddc:500.2 ,01 natural sciences ,7. Clean energy ,High Energy Physics - Experiment ,Nuclear physics ,Universal extra dimension ,High Energy Physics - Experiment (hep-ex) ,0103 physical sciences ,ddc:550 ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,diphoton ,events ,transverse energy ,proton-proton collisions ,Hadron ,ddc:530 ,High Energy Physics ,Specific model ,010306 general physics ,Nuclear Experiment ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,QC ,Physics ,Large Hadron Collider ,Science & Technology ,Compactification (physics) ,010308 nuclear & particles physics ,Atlas (topology) ,Settore FIS/01 - Fisica Sperimentale ,Física ,FIS/01 - Fisica Sperimentale ,Transverse plane ,Col·lisions (Física nuclear) ,Experimental High Energy Physics ,Universal Extra Dimensions ,Física nuclear ,High Energy Physics::Experiment ,LHC ,Particle Physics - Experiment - Abstract
A search for diphoton events with large missing transverse energy is presented. The data were collected with the ATLAS detector in proton-proton collisions at √s=7 TeV at the CERN Large Hadron Collider and correspond to an integrated luminosity of 3.1 pb−1. No excess of such events is observed above the standard model background prediction. In the context of a specific model with one universal extra dimension with compactification radius R and gravity-induced decays, values of 1/R, We wish to thank CERN for the efficient commissioning and operation of the LHC during this initial high-energy data-taking period as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF, DNSRC and Lundbeck Foundation, Denmark; ARTEMIS, European Union; IN2P3-CNRS, CEA-DSM/IRFU, France; GNAS, Georgia; BMBF, DFG, HGF, MPG and AvH Foundation, Germany; GSRT, Greece; ISF, MINERVA, GIF, DIP and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; FOM and NWO, Netherlands; RCN, Norway; MNiSW, Poland; GRICES and FCT, Portugal; MERYS (MECTS), Romania; MES of Russia and ROSATOM, Russian Federation; JINR; MSTD, Serbia; MSSR, Slovakia; ARRS and MVZT, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SER, SNSF and Cantons of Bern and Geneva, Switzerland; NSC, Taiwan; TAEK, Turkey; STFC, the Royal Society and Leverhulme Trust, United Kingdom; DOE and NSF, United States of America. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular, from CERN and the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA) and in the Tier-2 facilities worldwide., info:eu-repo/semantics/publishedVersion
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- 2011
16. Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling.
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Novelli F, Yoshikawa Y, Vitto VAM, Modesti L, Minaai M, Pastorino S, Emi M, Kim JH, Kricek F, Bai F, Onuchic JN, Bononi A, Suarez JS, Tanji M, Favaron C, Zolondick AA, Xu R, Takanishi Y, Wang Z, Sakamoto G, Gaudino G, Grzymski J, Grosso F, Schrump DS, Pass HI, Atanesyan L, Smout J, Savola S, Sarin KY, Abolhassani H, Hammarström L, Pan-Hammarström Q, Giorgi C, Pinton P, Yang H, and Carbone M
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- Humans, Female, Male, Middle Aged, Tumor Suppressor Protein p53 genetics, Tumor Suppressor Protein p53 metabolism, Apoptosis genetics, Fibroblasts metabolism, Asbestos toxicity, Genomic Instability, DNA Repair genetics, Tumor Suppressor Proteins genetics, Tumor Suppressor Proteins metabolism, Germ-Line Mutation, Ubiquitin-Protein Ligases genetics, Ubiquitin-Protein Ligases metabolism, Mesothelioma genetics, Genetic Predisposition to Disease, Calcium Signaling genetics
- Abstract
We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 ( BARD1) gene that were predicted to be damaging by computational analyses. We conducted functional assays, essential for accurate interpretation of missense variants, in primary fibroblasts that we established in tissue culture from a patient carrying the heterozygous BARD1
V523A mutation. We found that these cells had genomic instability, reduced DNA repair, and impaired apoptosis. Investigating the underlying signaling pathways, we found that BARD1 forms a trimeric protein complex with p53 and SERCA2 that regulates calcium signaling and apoptosis. We validated these findings in BARD1 -silenced primary human mesothelial cells exposed to asbestos. Our study elucidated mechanisms of BARD1 activity and revealed that heterozygous germline BARD1 mutations favor the development of mesothelioma and increase the susceptibility to asbestos carcinogenesis. These mesotheliomas are significantly less aggressive compared to mesotheliomas in asbestos workers., Competing Interests: Competing interests statement:M.C. has a patent issued for “Methods for Diagnosing a Predisposition to Develop Cancer.” M.C. and H.Y. have a patent issued for “Using Anti-HMGB1 Monoclonal Antibody or other HMGB1 Antibodies as a Novel Mesothelioma Therapeutic Strategy”, and a patent issued for “HMGB1 As a Biomarker for Asbestos Exposure and Mesothelioma Early Detection.” M.C. is a board-certified pathologist who provides consultation for pleural pathology, including medical-legal.- Published
- 2024
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17. The "via dialysis circuit" external bypass technique: External femoral to femoral bypass via dialysis circuit for antegrade perfusion of the ischemic limb.
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Sakamoto G, Shibata N, Watanabe N, Morita Y, and Morishima I
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A 71-year-old woman with no relevant previous medical history presented to the emergency department with cardiopulmonary arrest due to extensive myocardial infarction. Veno-arterial extracorporeal life support (ECLS) was passed through the right common femoral artery (CFA), and an Impella CP® (16-F introduction sheath, Abiomed Inc., Danvers, MA, USA) was inserted from the left CFA. Although these mechanical devices provide powerful cardiac and organ support, an occlusive large-bore sheath may induce ischemic limb complications. Antegrade flow from the contralateral sheath was circulated through the ECLS circuit, showing the improvement of antegrade left SFA. Cardiac function improved after primary percutaneous coronary intervention, but when the ECLS was terminated, antegrade left limb flow declined. Hence, we bypassed the contralateral flow via the dialysis circuit and prevented limb ischemia., Learning Objective: Although an Impella® (Abiomed Inc., Danvers, MA, USA) is useful for assisting left ventricular cardiac function, its large-bore sheath sometimes disturbs the antegrade flow, resulting in ischemic limb complications. A novel yet simple technique that involves an external bypass through the superficial femoral artery to provide antegrade perfusion to the ipsilateral limb is hereby described., Competing Interests: The author declares that there is no conflict of interest., (© 2023 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
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- 2023
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18. BAP1 is a novel regulator of HIF-1α.
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Bononi A, Wang Q, Zolondick AA, Bai F, Steele-Tanji M, Suarez JS, Pastorino S, Sipes A, Signorato V, Ferro A, Novelli F, Kim JH, Minaai M, Takinishi Y, Pellegrini L, Napolitano A, Xu R, Farrar C, Goparaju C, Bassi C, Negrini M, Pagano I, Sakamoto G, Gaudino G, Pass HI, Onuchic JN, Yang H, and Carbone M
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- Humans, Heterozygote, Mutation, Tumor Suppressor Proteins metabolism, Hypoxia-Inducible Factor 1, alpha Subunit genetics, Mesothelioma genetics, Mesothelioma metabolism, Mesothelioma, Malignant genetics, Mesothelioma, Malignant complications, Ubiquitin Thiolesterase metabolism
- Abstract
BAP1 is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals carrying germline BAP1 mutations often develop mesothelioma, an aggressive malignancy of the serosal layers covering the lungs, pericardium, and abdominal cavity. Intriguingly, mesotheliomas developing in carriers of germline BAP1 mutations are less aggressive, and these patients have significantly improved survival. We investigated the apparent paradox of a tumor suppressor gene that, when mutated, causes less aggressive mesotheliomas. We discovered that mesothelioma biopsies with biallelic BAP1 mutations showed loss of nuclear HIF-1α staining. We demonstrated that during hypoxia, BAP1 binds, deubiquitylates, and stabilizes HIF-1α, the master regulator of the hypoxia response and tumor cell invasion. Moreover, primary cells from individuals carrying germline BAP1 mutations and primary cells in which BAP1 was silenced using siRNA had reduced HIF-1α protein levels in hypoxia. Computational modeling and co-immunoprecipitation experiments revealed that mutations of BAP1 residues I675, F678, I679, and L691 -encompassing the C-terminal domain-nuclear localization signal- to A, abolished the interaction with HIF-1α. We found that BAP1 binds to the N-terminal region of HIF-1α, where HIF-1α binds DNA and dimerizes with HIF-1β forming the heterodimeric transactivating complex HIF. Our data identify BAP1 as a key positive regulator of HIF-1α in hypoxia. We propose that the significant reduction of HIF-1α activity in mesothelioma cells carrying biallelic BAP1 mutations, accompanied by the significant reduction of HIF-1α activity in hypoxic tissues containing germline BAP1 mutations, contributes to the reduced aggressiveness and improved survival of mesotheliomas developing in carriers of germline BAP1 mutations.
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- 2023
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19. BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos.
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Novelli F, Bononi A, Wang Q, Bai F, Patergnani S, Kricek F, Haglund E, Suarez JS, Tanji M, Xu R, Takanishi Y, Minaai M, Pastorino S, Morris P, Sakamoto G, Pass HI, Barbour H, Gaudino G, Giorgi C, Pinton P, Onuchic JN, Yang H, and Carbone M
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- Animals, Biomarkers, Tumor metabolism, Carcinogenesis, Cell Nucleus metabolism, Female, Gene-Environment Interaction, Germ-Line Mutation, HMGB1 Protein genetics, Heterozygote, Histone Deacetylase 1 genetics, Incidence, Inflammation, Male, Mesothelioma metabolism, Mice, Mutation, Prognosis, Protein Binding, Tumor Suppressor Proteins metabolism, Ubiquitin chemistry, Ubiquitin Thiolesterase metabolism, Asbestos, HMGB1 Protein chemistry, Histone Deacetylase 1 chemistry, Tumor Suppressor Proteins chemistry, Ubiquitin Thiolesterase chemistry
- Abstract
Carriers of heterozygous germline BAP1 mutations ( BAP1
+/- ) are affected by the "BAP1 cancer syndrome." Although they can develop almost any cancer type, they are unusually susceptible to asbestos carcinogenesis and mesothelioma. Here we investigate why among all carcinogens, BAP1 mutations cooperate with asbestos. Asbestos carcinogenesis and mesothelioma have been linked to a chronic inflammatory process promoted by the extracellular release of the high-mobility group box 1 protein (HMGB1). We report that BAP1+/- cells secrete increased amounts of HMGB1, and that BAP1+/- carriers have detectable serum levels of acetylated HMGB1 that further increase when they develop mesothelioma. We linked these findings to our discovery that BAP1 forms a trimeric protein complex with HMGB1 and with histone deacetylase 1 (HDAC1) that modulates HMGB1 acetylation and its release. Reduced BAP1 levels caused increased ubiquitylation and degradation of HDAC1, leading to increased acetylation of HMGB1 and its active secretion that in turn promoted mesothelial cell transformation., Competing Interests: Competing interest statement: M.C. has a patent issued for BAP1. M.C. and H.Y. have two patents issued for HMGB1. M.C. is a board-certified pathologist who provides consultation for pleural pathology, including medical–legal.- Published
- 2021
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20. Catheter ablation for non-paroxysmal atrial fibrillation accompanied by heart failure with preserved ejection fraction: feasibility and benefits in functions and B-type natriuretic peptide.
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Yamauchi R, Morishima I, Okumura K, Kanzaki Y, Morita Y, Takagi K, Nagai H, Watanabe N, Furui K, Yoshioka N, Miyazawa H, Shimojo K, Imaoka T, Sakamoto G, and Murohara T
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- Feasibility Studies, Humans, Natriuretic Peptide, Brain, Prognosis, Stroke Volume, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation, Heart Failure diagnosis
- Abstract
Aims: We aimed to examine the benefits of catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) accompanied by heart failure (HF) with preserved ejection fraction (HFpEF), in comparison with the benefits in patients with AF accompanied by HF with reduced ejection fraction (HFrEF) or patients with no HF., Methods and Results: From 1173 consecutive patients undergoing catheter ablation, 502 with non-paroxysmal AF were divided into three groups: no history of HF [plasma B-type natriuretic peptide (BNP) <100 pg/mL and no HF hospitalization; n = 125], HFpEF [left ventricular (LV) EF ≥50%; n = 293], and HF with midrange EF (HFmrEF) + HFrEF (LVEF <50%; n = 84) groups. The endpoints were AF recurrence at 1 year, changes in symptomatic and image-based functional status, and changes in BNP levels from baseline to 1 year. In the HFpEF group, AF recurred in 48 patients (16.4%) and 278 patients (94.8%) had sinus rhythm at 1 year; these values were comparable with those in the other groups. Significant improvement was observed in the left atrial diameter, LVEF, and New York Heart Association functional class in the HFpEF and HFmrEF + HFrEF groups. The BNP level significantly decreased irrespective of the index rate control status, and freedom from AF recurrence was an independent predictor of HF remission, defined as BNP <100 pg/mL at 1 year, in the HFpEF group., Conclusion: Catheter ablation is highly feasible for restoring sinus rhythm in non-paroxysmal AF with coexisting HFpEF, thereby improving cardiac function and BNP levels. Catheter ablation for AF may be an optional management strategy., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)
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- 2021
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21. In-hospital mortality among consecutive patients with ST-Elevation myocardial infarction in modern primary percutaneous intervention era ~ Insights from 15-year data of single-center hospital-based registry ~.
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Takagi K, Tanaka A, Yoshioka N, Morita Y, Yoshida R, Kanzaki Y, Watanabe N, Yamauchi R, Komeyama S, Sugiyama H, Shimojo K, Imaoka T, Sakamoto G, Ohi T, Goto H, Ishii H, Morishima I, and Murohara T
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- Aged, Female, Hospital Mortality, Hospitals statistics & numerical data, Humans, Male, Middle Aged, Odds Ratio, Percutaneous Coronary Intervention, Retrospective Studies, Risk Assessment, Risk Factors, ST Elevation Myocardial Infarction physiopathology
- Abstract
Objective: To clarify the association of detailed angiographic findings with in-hospital outcome after primary percutaneous coronary intervention (p-PCI) for ST-elevation myocardial infarction (STEMI) in Japan., Background: Data regarding the association of detailed angiographic findings with in-hospital outcome after STEMI are limited in the p-PCI era., Methods: Between January-2004 and December-2018, 1735 patients with STEMI (mean age, 68.5 years; female, 24.6%) who presented to the hospital in the 24-hours after symptom onset and underwent p-PCI were evaluated using the disease registries. The registry is an ongoing, retrospective, single-center hospital-based registry., Results: The 30-day mortality rate and in-hospital mortality rate were 7.7% and 9.2%, respectively. Independent predictors of in-hospital mortality were ejection fraction (EF) < 40% [adjusted Odds Ratio (aOR), 4.446, p < 0.001], culprit lesions in the left coronary artery (LCA) (aOR, 2.940, p < 0.001) compared with those in the right coronary artery, Killip class > II (aOR, 7.438; p < 0.001), chronic kidney disease (CKD) (aOR, 4.056; p < 0.001), final thrombolysis in myocardial infarction (TIMI) grades 0/1/2 (aOR, 1.809; p = 0.03), absence of robust collaterals (aOR, 17.309; p = 0.01) and hypertension (aOR, 0.449; p = 0.01)., Conclusions: Among the consecutive patients with STEMI, the in-hospital mortality rate after p-PCI significantly improved in the second half. Not only CKD, Killip class > II, and EF < 40%, but also the angiographic findings such as culprit lesions in the LCA, absence of very robust collaterals, and final TIMI grades <3 were associated with an increased risk of in-hospital mortality., Competing Interests: H.I received lecture fees from Astellas Pharma Inc., Astrazeneca Inc., Daiichi-Sankyo Pharma Inc., and MSD K. K. T.A. received lecture fees from Astellas Pharma, AstraZeneca, Bayer, Daiichi Sankyo, and Bristol-Myers Squibb. T.M received lecture fees from Bayel Pharmaceutical Co., Ltd., Daiichi-Sankyo Co., Ltd., Dainippon Sumitomo Pharma Co., Ltd., Kowa Co., Ltd., MSD K. K., Mitsubishi Tanabe Pharma Co., Nippon Boehringer Ingelheim Co., Ltd., Novartis Pharma K. K., Pfizer Japan Inc., Sanofi-aventis K. K., and Takeda Pharmaceutical Co., Ltd. T.M received an unrestricted research grant for Department of Cardiology, Nagoya University Graduate School of Medicine from Astellas Pharma Inc., Daiichi-Sankyo Co., Ltd., Dainippon Sumitomo Pharma Co., Ltd., Kowa Co., Ltd., MSD K. K., Mitsubishi Tanabe Pharma Co., Nippon Boehringer Ingelheim Co., Ltd., Novartis Pharma K. K., Otsuka Pharma Ltd., Pfizer Japan Inc., Sanofi-aventis K. K., Takeda Pharmaceutical Co., Ltd., and Teijin Pharma Ltd. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Published
- 2021
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22. The Mid-term Mortality and Mode of Death in Survivors with ST-elevation Myocardial Infarction.
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Yoshioka N, Takagi K, Tanaka A, Morita Y, Yoshida R, Kanzaki Y, Nagai H, Watanabe N, Yamauchi R, Komeyama S, Sugiyama H, Shimojo K, Imaoka T, Sakamoto G, Ohi T, Goto H, Ishii H, Morishima I, and Murohara T
- Subjects
- Aged, Aged, 80 and over, Hospital Mortality, Humans, Male, Proportional Hazards Models, Risk Factors, Survivors, Treatment Outcome, Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction surgery
- Abstract
Objective The popularity of primary percutaneous coronary intervention (p-PCI) for ST-elevation myocardial infarction (STEMI) has increased over the past decades. Despite improvements in in-hospital mortality rates, it is clinically important to investigate the prognoses after discharge. However, data on the mode of death and prognostic factors are limited. We analyzed these factors in a Japanese cohort in the modern p-PCI era. Methods Between January 2004 and December 2017, a total of 1,222 patients who underwent p-PCI within 24 hours from the onset of STEMI and were alive at discharge (mean age, 67.7 years old; men, 75.5%), were evaluated. The two-year mortality was analyzed using a Cox regression model, and the mode of death was evaluated. Results The rate of mortality at 2 years was 5.7%. Non-cardiac death was more frequent than cardiac death (62.6% vs. 37.4%). A Cox multivariate analysis identified the following as independent predictors of the 2-year mortality: hemoglobin (log-transformed) [adjusted hazard ratio (HR), 0.048; 95% confidence interval (CI), 0.008-0.29; p<0.001], age above 80 years old (adjusted HR, 2.26; 95% CI, 1.30-3.91; p=0.004), Killip class ≥II (adjusted HR, 1.99; 95% CI, 1.17-3.39; p=0.011), brain natriuretic peptide level (log-transformed) (adjusted HR, 1.47; 95% CI, 1.09-2.01; p=0.013), and body mass index (log-transformed) (adjusted HR, 0.16; 95% CI, 0.030-0.84; p=0.030). Conclusion This study demonstrated that the 2-year mortality was 5.7% in STEMI survivors after p-PCI. Non-cardiac death was more frequent than cardiac death. Compared to well-known clinical variables, angiographic findings did not have a significant influence on the mid-term mortality.
- Published
- 2021
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23. Germline BAP1 mutations induce a Warburg effect.
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Bononi A, Yang H, Giorgi C, Patergnani S, Pellegrini L, Su M, Xie G, Signorato V, Pastorino S, Morris P, Sakamoto G, Kuchay S, Gaudino G, Pass HI, Napolitano A, Pinton P, Jia W, and Carbone M
- Subjects
- Germ Cells metabolism, Heterozygote, Humans, Mitochondria metabolism, Skin pathology, Mitochondria genetics, Mutation genetics, Tumor Suppressor Proteins genetics, Ubiquitin Thiolesterase genetics
- Abstract
Carriers of heterozygous germline BAP1 mutations (BAP1
+/- ) develop cancer. We studied plasma from 16 BAP1+/- individuals from 2 families carrying different germline BAP1 mutations and 30 BAP1 wild-type (BAP1WT ) controls from these same families. Plasma samples were analyzed by liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS), ultra-performance liquid chromatography triple quadrupole mass spectrometry (UPLC-TQ-MS), and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS). We found a clear separation in the metabolic profile between BAP1WT and BAP1+/- individuals. We confirmed the specificity of the data in vitro using 12 cell cultures of primary fibroblasts we derived from skin punch biopsies from 12/46 of these same individuals, 6 BAP1+/- carriers and 6 controls from both families. BAP1+/- fibroblasts displayed increased aerobic glycolysis and lactate secretion, and reduced mitochondrial respiration and ATP production compared with BAP1WT . siRNA-mediated downregulation of BAP1 in primary BAP1WT fibroblasts and in primary human mesothelial cells, led to the same reduced mitochondrial respiration and increased aerobic glycolysis as we detected in primary fibroblasts from carriers of BAP1+/- mutations. The plasma and cell culture results were highly reproducible and were specifically and only linked to BAP1 status and not to gender, age or family, or cell type, and required an intact BAP1 catalytic activity. Accordingly, we were able to build a metabolomic model capable of predicting BAP1 status with 100% accuracy using data from human plasma. Our data provide the first experimental evidence supporting the hypothesis that aerobic glycolysis, also known as the 'Warburg effect', does not necessarily occur as an adaptive process that is consequence of carcinogenesis, but rather that it may also predate malignancy by many years and facilitate carcinogenesis.- Published
- 2017
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24. BAP1 regulates IP3R3-mediated Ca 2+ flux to mitochondria suppressing cell transformation.
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Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, and Carbone M
- Subjects
- Apoptosis genetics, Asbestos toxicity, Calcium Signaling, Cell Nucleus metabolism, Cell Survival, Cells, Cultured, DNA Damage, Epithelium, Fibroblasts, Gene-Environment Interaction, Humans, Protein Binding, Protein Stability, Tumor Suppressor Proteins deficiency, Tumor Suppressor Proteins genetics, Ubiquitin metabolism, Ubiquitin Thiolesterase deficiency, Ubiquitin Thiolesterase genetics, Calcium metabolism, Cell Transformation, Neoplastic drug effects, Cell Transformation, Neoplastic radiation effects, Cytoplasm metabolism, Endoplasmic Reticulum metabolism, Inositol 1,4,5-Trisphosphate Receptors metabolism, Mitochondria metabolism, Tumor Suppressor Proteins metabolism, Ubiquitin Thiolesterase metabolism
- Abstract
BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1
+/- ) developed one and often several BAP1-/- malignancies in their lifetime, mostly malignant mesothelioma, uveal melanoma, and so on. Moreover, BAP1-acquired biallelic mutations are frequent in human cancers. BAP1 tumour suppressor activity has been attributed to its nuclear localization, where it helps to maintain genome integrity. The possible activity of BAP1 in the cytoplasm is unknown. Cells with reduced levels of BAP1 exhibit chromosomal abnormalities and decreased DNA repair by homologous recombination, indicating that BAP1 dosage is critical. Cells with extensive DNA damage should die and not grow into malignancies. Here we discover that BAP1 localizes at the endoplasmic reticulum. Here, it binds, deubiquitylates, and stabilizes type 3 inositol-1,4,5-trisphosphate receptor (IP3R3), modulating calcium (Ca2+ ) release from the endoplasmic reticulum into the cytosol and mitochondria, promoting apoptosis. Reduced levels of BAP1 in BAP1+/- carriers cause reduction both of IP3R3 levels and of Ca2+ flux, preventing BAP1+/- cells that accumulate DNA damage from executing apoptosis. A higher fraction of cells exposed to either ionizing or ultraviolet radiation, or to asbestos, survive genotoxic stress, resulting in a higher rate of cellular transformation. We propose that the high incidence of cancers in BAP1+/- carriers results from the combined reduced nuclear and cytoplasmic activities of BAP1. Our data provide a mechanistic rationale for the powerful ability of BAP1 to regulate gene-environment interaction in human carcinogenesis.- Published
- 2017
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25. Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years.
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Honma N, Takubo K, Sawabe M, Arai T, Akiyama F, Sakamoto G, Utsumi T, Yoshimura N, and Harada N
- Subjects
- Adult, Aged, Breast Neoplasms epidemiology, Breast Neoplasms genetics, Carcinoma enzymology, Carcinoma epidemiology, Carcinoma genetics, Carcinoma, Ductal, Breast epidemiology, Carcinoma, Ductal, Breast genetics, Estrogens, Female, Gene Expression Regulation, Neoplastic, Humans, Isoenzymes genetics, Japan epidemiology, Middle Aged, Neoplasms, Hormone-Dependent enzymology, Neoplasms, Hormone-Dependent epidemiology, Neoplasms, Hormone-Dependent genetics, RNA, Messenger genetics, RNA, Neoplasm genetics, Receptors, Estrogen analysis, Aged, 80 and over physiology, Alternative Splicing, Aromatase genetics, Breast enzymology, Breast Neoplasms enzymology, Carcinoma, Ductal, Breast enzymology, Exons genetics, Neoplasm Proteins genetics
- Abstract
Introduction: Peripherally localized aromatase, which converts circulating androgens into estrogens, is important in the pathogenesis of postmenopausal breast carcinomas. We have previously shown that aromatase mRNA levels are higher in elderly breast carcinomas (EldCa) than breast carcinomas of the control group (ContCa) or normal breast tissues. Aromatase expression has been reported to be regulated through the alternative use of multiple exons 1 (exons 1a-1f and so on); however, the preferential usage of exons 1 in elderly breast tissue has never been systematically examined. In order to properly treat and protect against EldCa, the regulation mechanism of aromatase expression in elderly breast tissues should be elucidated. The aim of the present study is to elucidate whether there are any specific patterns in use of multiple exons 1 in elderly breast tissue., Methods: Usage of multiple exons 1 of the aromatase gene and mRNA levels of aromatase were examined by reverse transcription-polymerase chain reaction analysis in breast tissues of 38 elderly patients with breast cancer (age 80-99), and the results were compared with those in 35 patients of the control group (age 37-70). One-factor analysis of variance and the Scheffé test were used for the comparison of aromatase mRNA levels. Patterns of preferential utilization of multiple exons 1 of the aromatase gene were compared by chi2 test for independence or Fisher exact test for independence using a contingency table., Results: Exon 1d was utilized much more frequently in elderly tissue than in the control group irrespective of cancerous or normal tissue (EldCa, 36/38, 95% versus ContCa, 7/35, 20%, P < 0.0001; normal tissue of the elderly, EldNorm, 30/34, 88% versus normal tissue of controls, ContNorm, 2/29, 7%, P < 0.0001). Twenty EldCa (53%) and 12 EldNorm (35%) used both exons 1c and 1d; however, their dominance was reversed (EldCa, all 1d > 1c; EldNorm, all 1c > 1d)., Conclusions: Elderly breast tissues exhibited specific patterns in use of multiple exons 1, which at least partly explained the higher aromatase levels in EldCa. The mechanisms of how these specific patterns occur during aging and carcinogenesis should be further examined.
- Published
- 2009
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26. Common peak approach using mass spectrometry data sets for predicting the effects of anticancer drugs on breast cancer.
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Ushijima M, Miyata S, Eguchi S, Kawakita M, Yoshimoto M, Iwase T, Akiyama F, Sakamoto G, Nagasaki K, Miki Y, Noda T, Hoshikawa Y, and Matsuura M
- Abstract
We propose a method for biomarker discovery from mass spectrometry data, improving the common peak approach developed by Fushiki et al. (BMC Bioinformatics, 7:358, 2006). The common peak method is a simple way to select the sensible peaks that are shared with many subjects among all detected peaks by combining a standard spectrum alignment and kernel density estimates. The key idea of our proposed method is to apply the common peak approach to each class label separately. Hence, the proposed method gains more informative peaks for predicting class labels, while minor peaks associated with specific subjects are deleted correctly. We used a SELDI-TOF MS data set from laser microdissected cancer tissues for predicting the treatment effects of neoadjuvant therapy using an anticancer drug on breast cancer patients. The AdaBoost algorithm is adopted for pattern recognition, based on the set of candidate peaks selected by the proposed method. The analysis gives good performance in the sense of test errors for classifying the class labels for a given feature vector of selected peak values.
- Published
- 2007
27. Diagnostic ultrasonography and mammography for invasive and noninvasive breast cancer in women aged 30 to 39 years.
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Osako T, Takahashi K, Iwase T, Iijima K, Miyagi Y, Nishimura S, Tada K, Makita M, Akiyama F, Sakamoto G, and Kasumi F
- Subjects
- Adult, Female, Humans, Retrospective Studies, Sensitivity and Specificity, Breast Neoplasms diagnosis, Carcinoma in Situ diagnosis, Carcinoma, Ductal, Breast diagnosis, Mammography, Ultrasonography, Mammary
- Abstract
Purpose: To confirm which modality, ultrasonography (US) or mammography (MMG), is useful to detect breast cancer in women aged 30 to 39 years, and to compare the sensitivity and findings of these two modalities for invasive carcinoma and ductal carcinoma in situ (DCIS) in the diagnostic setting., Methods: We retrospectively evaluated the sensitivity and findings of these two modalities in 165 patients aged 30 to 39 years, who underwent surgery at the Cancer Institute Hospital between 2001 and 2003. US or MMG were performed after obtaining information on the other modalities previously used and physical examination. The abnormal findings of US were defined as mass lesions and focal hypoechoic areas due to breast cancer. The abnormal findings of MMG were defined as category 3 to 5 (Japanese Mammography Guidelines) masses, calcifications, and other findings due to cancer., Results: Of 165 patients, 147 patients (89%) mammographically showed dense breasts. Histologically, 146 (88%) were invasive carcinomas and 19 (12%) were DCIS. In all carcinomas, the sensitivity of US (95%) was higher than that of MMG (85%). The sensitivity of US for invasive carcinoma (99%) was higher than that of MMG (85%). On the other hand, the sensitivity of MMG for DCIS (89%) was much higher than that of US (68%)., Conclusions: US is more sensitive to detect breast cancers than MMG in this age range, especially for invasive carcinoma. On the other hand, MMG is useful for detecting DCIS, especially when it manifests with microcalcifications.
- Published
- 2007
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28. Diagnostic mammography and ultrasonography for palpable and nonpalpable breast cancer in women aged 30 to 39 years.
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Osako T, Iwase T, Takahashi K, Iijima K, Miyagi Y, Nishimura S, Tada K, Makita M, Akiyama F, Sakamoto G, and Kasumi F
- Subjects
- Adult, Breast Neoplasms epidemiology, Breast Neoplasms pathology, Female, Humans, Japan epidemiology, Medical Records, Palpation, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Breast Neoplasms diagnostic imaging, Mammography statistics & numerical data, Ultrasonography, Mammary statistics & numerical data
- Abstract
Purpose: To investigate the relationship between the tumor size of breast cancer by palpation and the sensitivity of mammography (MMG) and ultrasonography (US), and which modality can detect nonpalpable breast cancer in women aged 30 to 39 years., Methods: We retrospectively evaluated the tumor size by palpation, breast density, and the sensitivity of MMG and US in 165 patients aged 30 to 39 years. Palpation, US, and MMG were performed with prior knowledge of the results of other modalities. The tumor size on palpation were classified into Tnp; nonpalpable, T1p; 2 cm or less, T2p; more than 2 cm, but not more than 5 cm, and T3p; more than 5 cm., Results: Of 165 patients, 147 patients (89%) showed mammographically dense breasts. Of 165 cancers, 14 (8%) were Tnp, 40 (24%) were T1p, 82 (50%) were T2p, and 29 (18%) were T3p. The sensitivity of MMG was 57% (8 of 14) for Tnp, 78% (31 of 40) for T1p, 90% (74 of 82) for T2p, and 97% (28 of 29) for T3p. The sensitivity of US was 43% (6 of 14) for Tnp and 100% for palpable cancers. Of 14 nonpalpable cancers, 4 (29%), 4 (29%), and 2 (14%) could be detected by only MMG, bloody nipple discharge, and US., Conclusions: The sensitivity of MMG depends on the tumor size on palpation in this age range. MMG fails to detect relatively large palpable cancers. On the other hand, US can detect all palpable cancers. However, the sensitivity of US declines for nonpalpable cancers. For the detection of nonpalpable cancers, MMG, US, and nipple discharge are complementary modalities.
- Published
- 2007
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29. Malignant melanoma originating on the female nipple: a case report.
- Author
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Kinoshita S, Yoshimoto K, Kyoda S, Hirano A, Shioya H, Kobayashi S, Ishiji T, Komine K, Takeyama H, Uchida K, Morikawa T, and Sakamoto G
- Subjects
- Adult, Axilla, Breast Neoplasms therapy, Chemotherapy, Adjuvant, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Melanoma therapy, Nevus pathology, Nipples surgery, Skin Neoplasms therapy, Breast Neoplasms pathology, Melanoma pathology, Nipples pathology, Skin Neoplasms pathology
- Abstract
We report a very rare case of malignant melanoma arising on a female nipple. A 42-year-old housewife had suffered from a small dark brown nevus on her left nipple for about thirty years without any changes. Six months before her initial visit it had begun to enlarge and rapidly changed from dark brown to black. A small bleeding ulcer was also present in the center of the lesion. Malignant melanoma rather than mammary Paget's disease was suggested based on its clinical course. Excisional biopsy was performed to differentiate between mammary Paget's disease and malignant melanoma. The histopathological examination revealed malignant melanoma, about 4 mm in thickness. She then underwent wide excision with axillary lymph node dissection. The surgical margin was made in a 3 cm radius around the biopsy site. The excision included nipple, areola, and part of the underlying breast parenchyma, adipose tissue and corresponding superficial layer of fascia. Microscopy showed metastasis in one of 13 axillary lymph nodes. After the operation, the patient received adjuvant DAV-Ferron therapy. In such a case, conserving surgery based on correct diagnosis can achieve a good cosmetic result and optimal tumor control.
- Published
- 2007
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30. Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years.
- Author
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Honma N, Takubo K, Sawabe M, Arai T, Akiyama F, Sakamoto G, Utsumi T, Yoshimura N, and Harada N
- Subjects
- Adenocarcinoma, Mucinous enzymology, Adenocarcinoma, Mucinous genetics, Adenocarcinoma, Mucinous metabolism, Adult, Aged, Aged, 80 and over, Aromatase genetics, Breast Neoplasms genetics, Breast Neoplasms metabolism, Carcinoma, Ductal, Breast enzymology, Carcinoma, Ductal, Breast genetics, Carcinoma, Ductal, Breast metabolism, Carcinoma, Lobular enzymology, Carcinoma, Lobular genetics, Carcinoma, Lobular metabolism, Female, Humans, Hydroxysteroid Dehydrogenases genetics, Immunohistochemistry, Middle Aged, RNA, Messenger genetics, RNA, Messenger metabolism, Reverse Transcriptase Polymerase Chain Reaction, Steryl-Sulfatase genetics, Sulfotransferases genetics, Aromatase metabolism, Breast Neoplasms enzymology, Estrogens biosynthesis, Hydroxysteroid Dehydrogenases metabolism, Steryl-Sulfatase metabolism, Sulfotransferases metabolism
- Abstract
Context: Aromatase, steroid sulfatase, and 17beta-hydroxysteroid dehydrogenase type 1 (HSD-1) peripherally up-regulate, whereas estrogen sulfotransferase (EST) and HSD-2 down-regulate, the synthesis of active and more potent estrogens. These estrogen-metabolizing enzymes (EMEs) are important in postmenopausal breast cancers, but have never been systematically examined in breast cancers of the elderly., Objective and Design: mRNA levels of EMEs in cancerous and normal breast tissues from 39 elderly patients (age, 80-99 yr) were compared with those from 39 controls (age, 37-70 yr) or compared according to estrogen (ER)/progesterone (PR) receptor status., Results: Aromatase levels were higher in cancers of the elderly (EldCa) than in normal tissue of the elderly (P = 0.0008) or cancers of controls (P = 0.0033). In contrast, levels of steroid sulfatase and EST were higher in cancers of controls than normal tissue of controls (P = 0.0046 and P < 0.0001, respectively) or EldCa (P = 0.0001 and P < 0.0001, respectively). Levels of HSD-1 and HSD-2 did not differ significantly between any two of the categories. Among EldCa, HSD-1 levels were higher in ER/PR-positive than in ER/PR-negative carcinomas, whereas EST and HSD-2 exhibited opposite results., Conclusions: The importance of aromatase is relatively increased in EldCa. ER/PR-positive EldCa exhibited a pattern of EMEs more beneficial to the production of estrogen than did ER/PR-negative EldCa. The specific pattern exhibited in EldCa may elucidate the role of EMEs in the absence of ovarian estrogens in the pathogenesis of breast cancer.
- Published
- 2006
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31. Intraductal papilloma with bloody discharge from Montgomery's areolar tubercle examined by ductoscopy from the areola.
- Author
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Sakai T, Makita M, Akiyama F, Uehara K, Kasumi F, Horii R, and Sakamoto G
- Subjects
- Adult, Diagnosis, Differential, Exudates and Transudates metabolism, Female, Humans, Breast Neoplasms pathology, Exudates and Transudates cytology, Fibrocystic Breast Disease pathology, Nipples metabolism, Nipples pathology, Papilloma, Intraductal pathology
- Abstract
A patient with intraductal papilloma who had abnormal bloody discharge from Montgomery's areolar tubercle underwent mammary ductography, mammary ductoscopy from the tubercle, and microdochectomy.A 43-year-old woman who was being followed-up for left breast cancer noticed bloody discharge from Montgomery's areolar tubercle of the right breast. Because the discharge continued for 2 months, further examinations were conducted. Mammary ductoscopy of Montgomery's areolar tubercle showed a normal internal duct structure. The presence of yellowish superficial lesions suggested intraductal inflammation or superficial hyperplasia of the duct epithelium. Lavage cytology revealed benign papillary lesions. Since the discharge continued and we could not completely exclude malignancy, microdochectomy was performed. Histologically a lactiferous duct was connected to Montgomery's areolar tubercle and an intraductal papilloma was seen in part and considered to have caused the bloody discharge. Bloody discharge from Montgomery's areola tubercles is extremely rare, the present case was our first experience with ductoscopy of Montgomery's areolar tubercle out of 641 cases of mammary ductoscopy performed on patients with bloody nipple discharge from 1998 to 2004. In our case, Montgomery's areolar tubercles were connected to a lactiferous duct. Although there are a few breast carcinomas that cause bloody discharge and eruption of areola, areolar preservation should be performed with the knowledge that disease may also involve the areola through the lactiferous ducts.
- Published
- 2006
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32. High prevalence of HER-2/neu and p53 overexpression in inflammatory breast cancer.
- Author
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Sawaki M, Ito Y, Akiyama F, Tokudome N, Horii R, Mizunuma N, Takahashi S, Horikoshi N, Imai T, Nakao A, Kasumi F, Sakamoto G, and Hatake K
- Subjects
- Adenocarcinoma therapy, Adult, Age Factors, Aged, Biomarkers, Tumor metabolism, Breast Neoplasms therapy, Cause of Death, Cohort Studies, Disease-Free Survival, Female, Gene Expression Regulation, Neoplastic, Humans, Japan epidemiology, Middle Aged, Neoplasm Staging, Predictive Value of Tests, Prevalence, Prognosis, Retrospective Studies, Risk Assessment, Sensitivity and Specificity, Survival Analysis, Adenocarcinoma genetics, Adenocarcinoma mortality, Breast Neoplasms genetics, Breast Neoplasms mortality, Receptor, ErbB-2 analysis, Tumor Suppressor Protein p53 analysis
- Abstract
Background: Inflammatory breast cancer (IBC) is one of the most aggressive forms of breast cancer. Although the survival of patients with IBC has been greatly improved by the use of combined treatment modalities, women with IBC still have lower survival rates. We have summarized a single-center experience involving IBC patients. Our objectives are to clarify molecular alterations of HER-2/neu and p53 in IBC and to investigate the prognostic factors., Methods: Between January 1990 and December 2000, 57 patients with IBC were referred to the Cancer Institute Hospital of the Japanese Foundation for Cancer Research. The incidence of IBC among primary breast cancers was 1.0% (57/5,757) in our hospital. Forty-six patients meeting Haagensen's criteria for inflammatory breast carcinoma were evaluated. All patients had biopsy-proven carcinomas but no distant metastases at referral. The median age at diagnosis for IBC was 51.8 (range, 28 to 70). All patients underwent a mastectomy. Chemotherapy was performed pre- or post-operatively. Three-year and 5-year survival rates were 56.5%, and 40.7%, respectively. Expressions of HER-2/neu and the p53 protein were determined retrospectively by immunohistochemical (IHC) staining of thin paraffin-embedded sections of primary tumors., Results: Of 46 patients, 23 (50.0%) with tumors testing positive for HER-2/neu fared somewhat worse than those with negative tumors, but the differences were not significant for either overall survival (OS) or disease-free survival (DFS). Of 46 patients, 19 (41.3%) whose tumors were positive for p53 fared somewhat better than patients with negative tumors, with no significant differences in either OS or DFS. Patients presenting with less than ten pathologically involved axillary lymph nodes showed significantly better OS and DFS., Conclusions: Overexpression of HER-2/neu and the p53 protein were not significant prognostic factors in inflammatory breast cancer. However, the increased incidence of HER-2/neu and the poor outcome of IBC may be of clinical interest, suggesting the need for clinical trials of antibody therapy targeted to HER-2/neu. Moreover, a high prevalence of p53 may be useful in determining the specific use of chemotherapy.
- Published
- 2006
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33. Efficacy and safety of combined trastuzumab and Paclitaxel therapy as a second-line treatment in women with metastatic breast cancer: a single institutional experience.
- Author
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Furukawa K, Ito Y, Takahashi S, Sawaki M, Mizunuma N, Horikoshi N, Kasumi F, Akiyama F, Sakamoto G, Furukawa K, Tajiri T, and Hatake K
- Subjects
- Antibodies, Monoclonal, Humanized, Breast Neoplasms metabolism, Breast Neoplasms mortality, Drug Administration Schedule, Female, Humans, Infusions, Intravenous, Neutropenia chemically induced, Peripheral Nervous System Diseases chemically induced, Receptor, ErbB-2 metabolism, Retrospective Studies, Trastuzumab, Treatment Outcome, Antibodies, Monoclonal administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms pathology, Paclitaxel administration & dosage
- Abstract
Background: In breast cancer, HER-2 overexpression suggests s poor prognosis. Trastuzumab is a humanized monoclonal antibody with specificity to the HER-2 protein. We evaluated the safety and efficacy of combined trastuzumab and paclitaxel therapy in women with metastatic breast cancer., Patients and Methods: Combination chemotherapy was given to patients with HER-2 overexpressing metastatic breast cancer. All patients had previously received one or more chemotherapy treatments. Patients received a loading trastuzumab dose of 4 mg/kg intravenously (i.v.), followed by 2 mg/kg maintenance dose at weekly intervals. A paclitaxel dose of 80 mg/m(2) was administered on the same day as the trastuzumab infusion., Results: A total of 53 patients were examined. Seventy percent received two or more prior chemotherapy treatments for metastatic breast cancer, and 66.0% of patients had two or more metastatic sites. The overall response rate to our approach was 37.7%. Median time to progression was 12.0 months. Grade 3/4 neutropenia was seen in only 11.3% of patients. Peripheral neuropathy occurred in 65.1% of patients after seven treatments, requiring us to change to biweekly paclitaxel administration in 16 patients. Most of them were able to continue the treatment. Other toxicities were mild and tolerable., Conclusion: Combined trastuzumab and paclitaxel therapy, administered as second-line or later treatment, produced lasting objective responses and was well tolerated by women with HER-2 overexpressing metastatic breast cancer. A major obstacle to continuing treatment was peripheral neuropathy. However, modifying the interval to every 2 weeks enabled us to continue the treatment. This combination chemotherapy was safely performed in our outpatient clinic.
- Published
- 2006
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34. Postoperative prognosis of node-negative breast cancers predicted by gene-expression profiling on a cDNA microarray of 25,344 genes.
- Author
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Tsumagari K, Chijiiwa K, Nagai H, Makita M, Kasumi F, Akiyama F, Sakamoto G, and Miki Y
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms mortality, Breast Neoplasms pathology, Carcinoma, Ductal, Breast mortality, Carcinoma, Ductal, Breast pathology, Disease-Free Survival, Female, Health Status Indicators, Humans, Lymph Nodes pathology, Lymphatic Metastasis, Mastectomy, Middle Aged, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Postoperative Period, Predictive Value of Tests, Prognosis, Breast Neoplasms genetics, Carcinoma, Ductal, Breast genetics, Gene Expression Profiling methods, Neoplasm Recurrence, Local genetics
- Abstract
Background: In Japan, postoperative relapse occurs within five years in 9.2 to 16% of patients whose breast cancers have not metastasized to lymph nodes at the time of initial surgery(node-negative, n0). Attempts to find molecular markers able to classify n0 breast cancers in terms of postoperative prognosis have not been successful., Methods: To identify molecular indicators of prognosis for this type of cancer, we used a cDNA microarray consisting of 25,344 human genes to investigate expression profiles of 12 primary breast cancers from patients whose tumors recurred within five years after surgery(5Y-R) and 12 from patients who survived disease-free for more than five years (5Y-F)., Results: Sets of genes characterizing each group in terms of expression patterns in the tumors were selected by Mann-Whitney and random-permutation tests: these panels included 21 genes expressed highly in 5Y-R tumors than in 5Y-F tumors, and 37 with higher expression in the 5Y-F group than in the 5Y-R group., Conclusions: We established a scoring system to prediction of postoperative prognosis which was 100% accurate as to the actual clinical outcomes of the 24 cases and therefore might be useful for predicting prognosis of n0 breast cancers in a clinical setting. The prognostic score system clearly separated the two groups without any overlap, and accurately predicted prognosis in 6 additional cases. Moreover, the extensive list of tumor-related genes identified in these experiments provides valuable information about progression of breast cancer and suggests potential target molecules for therapy of n0 breast cancers.
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- 2005
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35. Spontaneous " healing" of breast cancer.
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Horii R, Akiyama F, Kasumi F, Koike M, and Sakamoto G
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- Aged, Aged, 80 and over, Breast Neoplasms pathology, Carcinoma pathology, Female, Fibrosis, Humans, Mastectomy, Segmental, Middle Aged, Breast pathology, Breast Neoplasms therapy, Carcinoma therapy, Neoplasm Regression, Spontaneous pathology
- Abstract
Background: Healing is a phenomenon by which the intraductal component of breast cancer disappears and is replaced by fibrous tissue. Focally localized healing often prevents confirmation of the continuity of intraductal carcinoma., Objective: To clarify the clinicopathological characteristics of breast cancer with healing., Patients and Methods: At our hospital, 308 patients (311 breasts) underwent breast conservation therapy without neoadjuvant chemotherapy for breast cancer in 2000. These surgical specimens were histopathologically investigated with 5 mm serial sections. We assessed the proportion and the characteristics of breast cancer with healing., Results: (1) The proportion of breast cancer with healing was 7% (21/311). (2) In the 21 patients, the mean age was 59.2 years, and the mean diameter was 2.8 cm. (3) The histological type of the breast cancer varied: noninvasive ductal carcinoma in 2 cases, papillotubular carcinoma in 5, solid-tubular carcinoma in 8, scirrhous carcinoma in 5, invasive lobular carcinoma in 1, and Paget's disease in 1. However in all cases, the histologic type of the intraductal carcinoma foci was the comedo/solid type and the nuclear grade of cancer cells was high. (4) In cases with healing, areas of healing were seen in an average of 5 (1-26) blocks, compared with intraductal carcinoma foci in 13 blocks (2-40). Healing was located on the nipple side of the main lesion in 8 cases, the peripheral side in 9, and both sides in 4. In 3 cases, healing was seen at the surgical margin of the partial mastectomy specimen., Conclusion: The proportion of breast cancer cases with healing was 7% and these cases were intraductal carcinoma of the comedo/solid type, consisting of highly malignant cancer cells.
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- 2005
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36. General rules for clinical and pathological recording of breast cancer 2005.
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Sakamoto G, Inaji H, Akiyama F, Haga S, Hiraoka M, Inai K, Iwase T, Kobayashi S, Sakamoto G, Sano M, Sato T, Sonoo H, Tsuchiya S, and Watanabe T
- Subjects
- Breast Neoplasms classification, Breast Neoplasms therapy, Female, Humans, Japan, Neoplasm Staging, Prognosis, Breast pathology, Breast Neoplasms pathology, Medical Records, Registries
- Published
- 2005
37. A case of carcinosarcoma of the breast.
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Tokudome N, Sakamoto G, Sakai T, Sarumaru S, Okuyama N, Hori F, Horii R, Akiyama F, Tanabe M, Saito K, Takahashi K, and Kasumi F
- Subjects
- Breast Neoplasms therapy, Carcinosarcoma therapy, Chemotherapy, Adjuvant, Female, Humans, Mastectomy, Modified Radical, Middle Aged, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local therapy, Radiotherapy, Adjuvant, Breast Neoplasms pathology, Carcinosarcoma pathology
- Abstract
Carcinosarcoma is a rare malignant tumor of the breast. A 59-year-old woman was admitted to our hospital with a complaint of a right breast mass for one month. The mass grew rapidly, and modified radical mastectomy was performed. Based on the histological findings of carcinomatous and sarcomatous components entangled without a transition area, and the results of immunohistochemical staining, carcinosarcoma of the breast was diagnosed. Within 9 months of the surgery, a recurrent lesion appeared in her chest wall. As shown by local resection, this recurrent tumor had only a carcinomatous component. Such tumors are very rare, and there have been no detailed reports of recurrence patterns of carcinosarcoma. Here we report our pathological findings in detail.
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- 2005
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38. Classification of ipsilateral breast tumor recurrence after breast-conserving therapy: new primary cancer allows a good prognosis.
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Nishimura S, Takahashi K, Akiyama F, Oguchi M, Tada K, Makita M, Iwase T, Yoshimoto M, Yamashita T, Sakamoto G, and Kasumi F
- Subjects
- Breast Neoplasms mortality, Disease-Free Survival, Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Mastectomy statistics & numerical data, Neoplasm Recurrence, Local mortality, Neoplasm Recurrence, Local surgery, Prognosis, Radiotherapy, Adjuvant statistics & numerical data, Reoperation statistics & numerical data, Salvage Therapy statistics & numerical data, Breast Neoplasms pathology, Breast Neoplasms therapy, Mastectomy, Segmental, Neoplasm Recurrence, Local classification
- Abstract
Purpose: To classify and assess ipsilateral breast tumor recurrences (IBTR) after breast-conserving therapy., Methods: Between 1986 and 2001, 2,137 patients who had breast cancer underwent breast-conserving surgery with or without radiotherapy at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research. Of these patients, 83 (3.9%) had an IBTR. We classified the IBTR as a new primary cancer (NP) if the primary tumor had completely negative margins at first operation by detailed pathological examination and if the IBTR had an intraductal component. All other IBTRs were judged true local recurrence (TR)., Results: Of the 83 patients, 42 patients were classified as TR (29 had no radiotherapy) and 41 as NP (40 had no radiotherapy). Mean time to disease recurrence was 37 months for TR (52% were within 2 years) versus 55 months for NP (19% were within 2 years) (p=0.031). Six patients (14%) with TR did not receive re-operation, and 67% received salvage mastectomy and 19% re-lumpectomy. All cases of NP were operable, 78% underwent salvage mastectomy and 22% underwent re-lumpectomy. Distant metastases were observed in 33% of patients with TR and 5% of patients with NP, and cause-specific death occurred in 6 cases with TR and in one with NP. The patients with NP had improved 5-year rates of overall survival (NP 91% vs. TR 76%, P=0.0627) and distant disease-free survival (NP 93% vs. TR 61%, P=0.0028). Patients with NP more often developed contralateral breast cancer (NP 37% vs. TR 12%, P=0.018), Conclusions: Patients with NP had better survival rates than those with TR. Distinguishing new primary breast carcinomas from local disease recurrences may have importance in therapeutic decisions and chemoprevention strategies.
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- 2005
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39. Huge cavernous hemangioma arising in a male breast.
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Kinoshita S, Kyoda S, Tsuboi K, Son K, Usuba T, Nakasato Y, Kashiwagi H, Komine K, Takeishi M, Sato S, Takeyama H, Uchida K, Yamazaki Y, and Sakamoto G
- Subjects
- Biopsy, Needle, Breast Neoplasms, Male surgery, Hemangioma, Cavernous surgery, Humans, Magnetic Resonance Imaging, Male, Mastectomy, Middle Aged, Tomography, X-Ray Computed, Treatment Outcome, Breast Neoplasms, Male diagnosis, Hemangioma, Cavernous diagnosis
- Abstract
We report a rare case of a huge cavernous hemangioma arising in a male breast. A 60-year-old man first noticed 1 x 2 cm elastic hard nodule just below his right nipple ten years previously. It enlarged 5 x 5 cm over six years. When he came to our clinic, it was size of child head (510 mm in circumference),was an elastic hard with a rather smooth surface, and firmly fixed to the chest wall. Magnetic resonance imaging (MRI) and multidetectocomputed tomography (MDCT)showed a large mass infiltrating into the chest wall. Fine needle aspiration cytology (FNA) and core needle biopsy (CNB) failed to obtain proper material except for old bloody fluid or necrotic connective tissue, precluding a correct diagnosis preoperatively. Mastectomy with partial resection of the chest wall was subsequently performed. Histologically, it was found to be a cavernous hemangioma without cellular atypia. In such a case, complete excision is recommended to exclude the possibility of an underlying malignant lesion.
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- 2005
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40. Clinical and pathological features of glycogen-rich clear cell carcinoma of the breast.
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Kuroda H, Sakamoto G, Ohnisi K, and Itoyama S
- Subjects
- Adenocarcinoma, Clear Cell genetics, Adenocarcinoma, Clear Cell pathology, Adult, Aged, Breast Neoplasms genetics, Breast Neoplasms pathology, Carcinoma, Ductal, Breast genetics, Carcinoma, Ductal, Breast pathology, Female, Genes, erbB-2, Humans, Lymphatic Metastasis, Middle Aged, Prognosis, Adenocarcinoma, Clear Cell metabolism, Breast Neoplasms metabolism, Carcinoma, Ductal, Breast metabolism, Glycogen metabolism
- Abstract
Background: Twenty cases of invasive ductal carcinoma of the breast with a pure or partial glycogen-rich clear cell carcinoma(GRCC)component are reported. GRCC of the breast is composed almost entirely of polygonal cells with clear cytoplasm. These contain large amounts of partly water-soluble glycogen., Methods: The cases were analyzed using various parameters, including age at presentation, tumor size, tumor grade, axillary lymph node and Her2/neu status., Results: Between 1990 and 2004, 723 patients with primary breast carcinomas were treated and clinicopathologic analysis was performed. 20 cases were identified as GRCC among the 723 cases. The patients' age at presentation ranged from 33 to 68 years (mean, 52 years). Tumor size ranged from 1 to 6.5 cm (mean, 2.6 cm); 35% (7 of 20) of cases that underwent axillary dissection had positive lymph nodes. Among 15 of 20 cases who were followed for 1-72 months, 5 cases died from their breast carcinoma within 5 years following the diagnosis., Conclusion: Our series included more small size carcinomas than did previous series. Lymph node status does not appear to be markedly different from that of the usual invasive ductal carcinomas. Her2/neu expression was similar to that found in common breast carcinomas.
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- 2005
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41. Improvement in the prognosis of Japanese breast cancer patients from 1946 to 2001--an institutional review.
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Yoshimoto M, Tada K, Hori H, Morota A, Tanabe M, Nishimura S, Takahashi K, Makita M, Iwase T, Kasumi F, Takahashi S, Ito Y, Oguchi M, Yamashita T, Akiyama F, and Sakamoto G
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms pathology, Breast Neoplasms surgery, Combined Modality Therapy, Female, Humans, Japan epidemiology, Lymph Node Excision statistics & numerical data, Lymphatic Metastasis, Mastectomy methods, Menopause, Middle Aged, Neoplasm Staging, Prognosis, Survival Rate, Time Factors, Breast Neoplasms mortality, Breast Neoplasms therapy, Mastectomy statistics & numerical data
- Abstract
Background: Breast cancer has emerged as one of the most frequent malignancies among Japanese women; however, the long-term survival of Japanese breast cancer patients is uncertain., Methods: We analyzed the chronological changes in the clinical and pathological characteristics, treatment procedures and the long-term prognosis of 15 416 Japanese women with 16 217 primary breast cancers treated in the Cancer Institute Hospital in Tokyo between 1946 and 2001., Results: Our analysis revealed a chronological increase in the mean patient age, postmenopausal patients and non-invasive carcinomas. Operative procedures became less extensive, with approximately 45% of breast cancer patients in 2000-2001 receiving breast-conserving treatment. Radiotherapy to the regional lymph nodes decreased, while postoperative chemotherapy and hormonal treatments have become more frequent. The survival rate has improved steadily during the past 5 decades. The 10-year crude overall survival rate improved from 61% before 1960 to 83% in the 1990s., Conclusions: The survival rate of Japanese women with breast cancer has dramatically improved during the past 5 decades.
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- 2004
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42. Expression profiling to predict postoperative prognosis for estrogen receptor-negative breast cancers by analysis of 25,344 genes on a cDNA microarray.
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Nagahata T, Onda M, Emi M, Nagai H, Tsumagari K, Fujimoto T, Hirano A, Sato T, Nishikawa K, Akiyama F, Sakamoto G, Kasumi F, Miki Y, Tanaka T, and Tsunoda T
- Subjects
- Adult, Aged, Biomarkers, Tumor analysis, DNA Primers, Disease Progression, Female, Gene Expression Profiling, Humans, Middle Aged, Neoplasm Invasiveness, Oligonucleotide Array Sequence Analysis, Postoperative Period, Prognosis, Reverse Transcriptase Polymerase Chain Reaction, Breast Neoplasms genetics, Breast Neoplasms pathology, Gene Expression Regulation, Neoplastic, RNA, Neoplasm analysis, Receptors, Estrogen metabolism
- Abstract
Estrogen receptor (ER) status is an essential determinant of clinical and biological behavior of human breast cancers. While ER-positive breast cancers respond well to adjuvant hormone therapy, ER-negative tumors are generally resistant. To date, no attempts have succeeded in finding molecular markers for classifying ER-negative breast cancers with respect to postoperative prognosis. To identify a set of prognostic markers for this type of cancer, we used a cDNA microarray consisting of 25,344 human genes to investigate expression profiles of ten primary breast cancers from patients who had died of breast cancer within 5 years after surgery (5y-D) and 10 from patients who had survived disease-free for more than 5 years (5y-S). Sets of genes characterizing each group were identified by Mann-Whitney and random-permutation tests. We documented 71 genes with higher expression in the 5y-D group than in the 5y-S group, and 15 with higher expression in the 5y-S group than in the 5y-D group. Semi-quantitative RT-PCR experiments were carried out to confirm the results of the microarray analysis. We established a scoring system for predicting postoperative prognosis of ER-negative breast cancers on the basis of aberrant gene expression. The list of genes reported here provides valuable information with regard to progression of breast cancer and is a source of possible target molecules for development of novel drugs to treat patients with ER-negative breast cancers.
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- 2004
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43. Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia.
- Author
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Kown MH, Suzuki T, Koransky ML, Penta K, Sakamoto G, Jahncke CL, Carter AJ, Quertermous T, and Robbins RC
- Subjects
- Adenoviridae genetics, Animals, Coronary Angiography, Coronary Circulation drug effects, Female, Gene Frequency, Swine, Ventricular Function, Left drug effects, Ventricular Function, Left physiology, Carrier Proteins pharmacology, Myocardial Ischemia physiopathology, Vascular Endothelial Growth Factor A pharmacology
- Abstract
Background: This study compared the angiogenic effects of developmental endothelial locus-1 (DEL-1), vascular endothelial growth factor (VEGF), as well as the negative control, beta-galactosidase (beta-gal), in a porcine model of cardiac ischemia., Methods: Twenty pigs underwent left circumflex artery occlusions. After 3 weeks, the animals received myocardial injections of adenovirus expressing beta-gal (n=6), DEL-1 (n=7), or VEGF (n=7). At 7 weeks, animals were assessed for both function and coronary flow and compared with baseline measurements., Results: Regional wall motion index and global ejection fraction showed deterioration in function in the beta-gal group and no change in the VEGF and DEL-1 groups between the treatment and harvest time points. Preload recruitable stroke work suggested functional improvement in the VEGF group (35.8 +/- 8.6 vs 56.4 +/- 17.8, p = 0.033). The increase in the DEL-1 group was not statistically significant (27.3 +/- 9.8 vs, 40.2 +/- 19.4, p = 0.067). The beta-gal group exhibited minimal change (30.7 +/- 14.8 vs 35.9 +/- 12.1, p = 0.96). Regional blood flow as assessed by fluorescent microspheres was improved under stress conditions in the VEGF group (1.00 +/- 0.15 vs 1.15 +/-0.22, p = 0.03)., Conclusions: Treatment with VEGF led to a modest improvement in regional blood flow and cardiac function in previously ischemic myocardial tissue.
- Published
- 2003
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44. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1.
- Author
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Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, and Varner JA
- Subjects
- Animals, Calcium-Binding Proteins, Carrier Proteins metabolism, Cell Adhesion Molecules, Endothelial Growth Factors genetics, Hindlimb blood supply, Homeodomain Proteins genetics, Integrins metabolism, Intercellular Signaling Peptides and Proteins genetics, Ischemia physiopathology, Lymphokines genetics, Mice, Mice, Inbred C57BL, Receptors, Vitronectin metabolism, Transcription Factors, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors, Carrier Proteins genetics, DNA-Binding Proteins, Genetic Therapy, Ischemia therapy, Neovascularization, Physiologic
- Abstract
The ECM protein Del-1 is one of several novel ECM proteins that accumulate around angiogenic blood vessels in embryonic and tumor tissue and promote angiogenesis in the absence of exogenous growth factors. Del-1 expressed in mouse or rabbit ischemic hind-limb muscle by gene transfer rapidly promotes new blood vessel formation and restores muscle function. This angiogenic ECM protein initiates angiogenesis by binding to integrin alphavbeta5 on resting endothelium, thereby resulting in expression of the transcription factor Hox D3 and integrin alphavbeta3. Hox D3 converts resting endothelium to angiogenic endothelium by inducing expression of proangiogenic molecules such as integrin alphavbeta3. These findings provide evidence for an angiogenic switch that can be initiated in the absence of exogenous growth factors and indicate that the angiogenic matrix protein Del-1 may be a useful tool for the therapy of ischemic disease.
- Published
- 2003
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45. Long-term results of breast-conserving treatment for early-stage breast cancer in Japanese women from multicenter investigation.
- Author
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Ohsumi S, Sakamoto G, Takashima S, Koyama H, Shin E, Suemasu K, Nishi T, Nakamura S, Iino Y, Iwase T, Ikeda T, Teramoto S, Fukutomi T, Komaki K, Sano M, Sugiyama K, Miyoshi K, Kamio T, and Ogita M
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms mortality, Breast Neoplasms pathology, Chemotherapy, Adjuvant, Combined Modality Therapy, Disease-Free Survival, Female, Follow-Up Studies, Humans, Japan epidemiology, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Survival Rate, Tamoxifen therapeutic use, Breast Neoplasms surgery, Mastectomy, Segmental
- Abstract
Background: Although many clinical data regarding breast-conserving treatment have already been reported from European and North American countries, few clinical data with long-term follow-up have been reported from Japan., Method: We collected information on therapeutic and possible or developed prognostic factors and follow-up data for Japanese women who had received breast-conserving treatment consisting of wide excision of the primary tumor, axillary dissection and radiotherapy for unilateral breast cancer considered suitable for breast-conserving treatment from 18 Japanese major breast cancer treating hospitals; 1561 patients were registered., Results: The median follow-up period was 77 months. Five-year disease-free and overall survival rates were 89.4 and 95.9%, respectively. The 5-year local recurrence-free rate was 96.3%. The patients with histologically positive margins (P < 0.0001) or estrogen receptor negative tumor (P = 0.0340) or younger than 40 years old (P < 0.0001) developed statistically significantly more local recurrences. Adjuvant endocrine therapy was essential for the estrogen receptor positive patients to have a lower local recurrence rate. Endocrine therapy did not change the local recurrence rate among estrogen receptor negative patients at all. Multivariate analysis showed histological margin status and the combination of estrogen receptor status and endocrine therapy were independent prognostic factors for local recurrence., Conclusion: The 5-year local recurrence rate of Japanese breast cancer patients who were treated with breast-conserving treatment using radiotherapy was 3.7%. Independent prognostic factors for local recurrence were histological margin status and the combination of estrogen receptor status and adjuvant endocrine therapy.
- Published
- 2003
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46. Indications for sentinel lymph node biopsy in patients with breast cancer: retrospective and simulation analyses.
- Author
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Koizumi M, Makita M, Yoshimoto M, Kasumi F, Sakamoto G, and Ogata E
- Subjects
- Adult, Aged, Axilla, Breast Neoplasms pathology, Female, Humans, Lymphatic Metastasis diagnosis, Middle Aged, Prognosis, Retrospective Studies, Breast pathology, Breast Neoplasms diagnosis, Sentinel Lymph Node Biopsy statistics & numerical data
- Abstract
Background: The disease status of axillary lymph nodes at diagnosis is the most powerful predictor of prognosis for patients with breast cancer. Axillary lymph node dissection (ALND) has been the standard treatment. Recently, lymphatic mapping and sentinel lymph node biopsy (SNB) have been suggested as alternatives to ALND. However, a clear indication for SNB has not yet been established. The goal of this study was to determine which patients might best benefit from the SNB method., Methods: A retrospective study compared the relationship of age, menopausal status, tumor size group, histology and clinical evaluation of nodes to histological axillary lymph node status in 5892 consecutive Japanese breast cancer patients who underwent ALND. A simulation analysis with reported SNB sensitivity and specificity was carried out., Results: Clinical lymph node evaluation was the most relevant factor to predict axillary nodal status. However, even patients with no clinical nodal involvement (N0) showed only 71% axillary nodal negativity. Tumor group based on tumor size and histology also related to axillary nodal status. The simulation analysis revealed that of patients with negative lymph node probability, more than 66% were good candidates for SNB., Conclusion: The clinically negative node (N0) is the most important indication for SNB. Therefore, the candidates for SNB should be picked from the patients with N0. When no histological information is available, patients whose tumor is 20 mm or smaller are candidates for SNB. When histological information is available, the SNB indication extends to patients whose type of tumor has histologically good prognosis or a low probability of having nodal involvement, regardless of tumor size.
- Published
- 2002
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47. Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers.
- Author
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Tsuneizumi M, Emi M, Nagai H, Harada H, Sakamoto G, Kasumi F, Inoue S, Kazui T, and Nakamura Y
- Subjects
- Alleles, Amino Acid Sequence, Base Sequence, Breast Neoplasms pathology, Cloning, Molecular, DNA, Complementary chemistry, DNA, Complementary genetics, DNA, Neoplasm chemistry, DNA, Neoplasm genetics, Exons, Female, Gene Amplification, Gene Expression Regulation, Neoplastic, Genes genetics, HeLa Cells, Humans, Introns, Molecular Sequence Data, Neoplasm Staging, Physical Chromosome Mapping, Polymorphism, Single-Stranded Conformational, Proto-Oncogene Proteins c-myc genetics, Sequence Analysis, DNA, Tumor Cells, Cultured, Antigens, Neoplasm, Antigens, Surface genetics, Breast Neoplasms genetics, Chromosomes, Human, Pair 8 genetics
- Abstract
EBAG9, an estrogen-responsive gene located at 8q23 was identified in an effort to clone CpG-binding sites. Its product was later found to be identical to RCAS1, a cancer cell-surface antigen implicated in immune escape. We determined the sequence of the complete cDNA and the genomic structure for EBAG9. EBAG9 gene copy number in 21% (27 of 129) primary breast cancers we examined; EBAG9 mRNA was consistently expressed in cancer cell lines. Detailed physical mapping of the 8q arm, including polymorphic markers for EBAG9 and the CMYC loci, revealed allelic gain of either EBAG9, CMYC, or both, in 45% (58 of 129) of the breast cancers we examined. The EBAG9 gene was increased exclusively in 16 of the 27 tumors showing gain at that locus; the other 11 showed gain of a larger chromosomal region containing both EBAG9 and CMYC. Analysis of subsequent series of 144 primary breast cancers for allelic gain at EBAG9 and CMYC locus showed a similar degree of gain at EBAG9, CMYC, or both. When a total of 273 breast cancers from two series were combined and analyzed for clinicopathological correlation, almost all of the tumors with EBAG9 increased but not those with CMYC. Twenty-eight of 29 were T1/T2 stage carcinomas (<5 cm in diameter), whereas one third (21 of 61) of the tumors in which CMYC was increased but EBAG9 was not, were advanced T3-stage tumors (P = 0.0012). These data suggest that EBAG9 and CMYC gene are independent targets of gain and that overrepresentation of EBAG9 may play a specific role in early stages of breast carcinogenesis.
- Published
- 2001
48. Association of allelic losses at 3p25.1, 13q12, or 17p13.3 with poor prognosis in breast cancers with lymph node metastasis.
- Author
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Haga S, Emi M, Hirano A, Utada Y, Kajiwara T, Akiyama F, Sakamoto G, Takahashi K, Tada T, Kasumi F, Miki Y, and Nakamura Y
- Subjects
- Adult, Aged, Breast Neoplasms mortality, Breast Neoplasms pathology, Female, Humans, Microsatellite Repeats genetics, Middle Aged, Multivariate Analysis, Neoplasm Invasiveness genetics, Prognosis, Survival Rate, Breast Neoplasms diagnosis, Breast Neoplasms genetics, Chromosomes, Human, Pair 13 genetics, Chromosomes, Human, Pair 17 genetics, Chromosomes, Human, Pair 3 genetics, Loss of Heterozygosity genetics, Lymphatic Metastasis genetics
- Abstract
To identify specific allelic losses that might correlate with postoperative mortality of patients with node-positive breast carcinomas, we examined tumors from a cohort of 263 such patients, who were followed clinically for 5 years postoperatively, for allelic losses among 18 microsatellite markers. Patients whose tumors had lost an allele at 3p25.1, 13q12, or 17p13.3 had significantly higher risks of mortality than those whose tumors retained both alleles at those loci. At 3p25.1, the 5-year mortality rate was 33.8% among patients with losses vs. 16.8% with retention (P = 0.0154); at 13q12, 30.3% vs. 13.0% (P = 0.0241); and at 17p13.3, 30.4% vs. 16.2% (P = 0.0243). Combined losses at 3p25.1 and 17p13.3 increased the predicted postoperative mortality risk by a factor of 4.9 (5-year mortality rate of 38.2% vs. 8.0%, P = 0.0006), and combined losses at 3p25.1 and 13q12 raised the predicted postoperative mortality risks by a factor of 2.9 (34.7% vs. 12.7%, P = 0.0441). These data indicate that loss of heterozygosity (LOH) at any one or a pair of loci at 3p25.1, 13q12, or 17p13.3 is a significant predictor of postoperative mortality for breast-cancer patients.
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- 2001
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49. Allelic losses of loci at 3p25.1, 8p22, 13q12, 17p13.3, and 22q13 correlate with postoperative recurrence in breast cancer.
- Author
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Hirano A, Emi M, Tsuneizumi M, Utada Y, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Haga S, Kajiwara T, and Nakamura Y
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms diagnosis, Breast Neoplasms mortality, Breast Neoplasms prevention & control, Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 22, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 8, Disease-Free Survival, Female, Genetic Markers, Humans, Middle Aged, Recurrence, Breast Neoplasms genetics, Chromosomes, Loss of Heterozygosity genetics
- Abstract
We previously defined 18 chromosomal regions in which frequent allelic losses were observed in breast cancers (T. Sato et al., Cancer RES:, 50: 7184-7189, 1990; Y. Harada et al., Cancer (PHILA:), 74: 2281-2286, 1994; I. Ito et al., BR: J. Cancer, 71: 438-441, 1995; K. Tsukamoto et al., Cancer (PHILA:), 78: 1929-1934, 1996; S. Matsumoto et al., Genes Chromosomes Cancer, 20: 268-274, 1997; T. Yokota et al., JPN: J. Cancer RES:, 88: 959-964, 1997; K. Tsukamoto et al., Cancer (PHILA:), 82: 317-322, 1998; A. Iida et al., Genes Chromosomes Cancer, 21: 108-112, 1998; K. Fukino et al., Genes Chromosomes Cancer, 24: 345-350, 1999; T. Yokota et al., Cancer (PHILA:), 85: 447-452, 1999; Y. Utada et al., JPN: J. Cancer RES:, 91: 293-300, 2000). To identify specific allelic losses that might correlate with postoperative recurrence, we examined tumors from a cohort of 504 breast cancer patients, who were followed clinically for 5 years postoperatively, for allelic losses of 18 microsatellite markers. Patients whose tumors had lost an allele at 3p25.1, 8p22, 13q12, 17p13.3, or 22q13 had significantly higher risks of recurrence than those whose tumors retained both alleles at those loci; at 3p25.1, the 5-year recurrence rate was 27% among patients with losses versus 18% with retention (P = 0.0131); at 8p22, 27% versus 14% (P = 0.0129); at 13q12, 28% versus 15% (P = 0.0109); at 17p13.3, 27% versus 20% (P = 0.0482); and at 22q13, 29% versus 20% (P = 0.0477). These data indicate that loss of heterozygosity at any one of these five specific loci is a significant predictor of postoperative recurrence among patients who have undergone surgery for breast cancer. These allelic losses can serve as negative prognostic indicators to guide postoperative management of patients.
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- 2001
50. Stereotactic radiosurgery in patients with multiple brain metastases.
- Author
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Chang SD, Lee E, Sakamoto GT, Brown NP, and Adler JR Jr
- Subjects
- Adult, Aged, Brain pathology, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Necrosis, Radiation Injuries, Retrospective Studies, Treatment Outcome, Brain Neoplasms secondary, Brain Neoplasms surgery, Radiosurgery methods
- Abstract
Object: Patients with multiple brain metastases are often treated primarily with fractionated whole-brain radiation therapy (WBRT). In previous reports the authors have shown that patients with four or fewer brain metastases can benefit from stereotactic radiosurgery in addition to fractionated WBRT. In this paper the authors review their experience using linear accelerator stereotactic radiosurgery to treat patients with multiple brain metastases., Methods: Fifty-three patients with 149 brain metastases underwent stereotactic radiosurgery. The mean age of patients was 53.1 years (range 20-78 years). There were 23 men and 30 women. The primary tumor location was lung (27 patients), melanoma (10), breast (six), ovary (six), and other (four). All patients harbored at least two metastatic tumors treated with radiosurgery; 27 patients (51%) harbored two lesions, 17 (32%) three lesions, eight (15%) four lesions, and one patient (2%) harbored five lesions. The mean radiation dose administered was 19.6 Gy (range 14-30 Gy), and the mean secondary collimator size was 15.7 mm (range 7.5-40 mm). One hundred thirty-two (89%) of the 149 treated tumors were available for review on magnetic resonance (MR) imaging at 3 months posttreatment. Fifty-two percent were smaller in size, 31% were stable, 9% had increased in size, and 8% had disappeared. New metastatic tumors appeared in 12 (23%) of the 53 patients on MR imaging within 6 months posttreatment. Radiation-induced necrosis occurred at the site of eight (5.4%) of the 149 tumors at 6 months. Seven tumors (4.7%) subsequently required surgical resection for either tumor progression (four cases) or worsening edema from radiation-induced necrosis (three cases). Median actuarial survival was 9.6 months., Conclusions: Stereotactic radiosurgery can be used to treat patients with up to four brain metastases with a 91% rate of either decrease or stabilization in tumor size and a low rate of radiation-induced necrosis. In the authors' study only a small number of patients subsequently required surgical resection of a treated lesion.
- Published
- 2000
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