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2. K-Means Clustering Identifies Diverse Clinical Phenotypes in COVID-19 Patients: Implications for Mortality Risks and Remdesivir Impact

Author

Garcia-Vidal, Carolina, Teijón-Lumbreras, Christian, Aiello, Tommaso Francesco, Chumbita, Mariana, Menendez, Rosario, Mateu-Subirà, Aina, Peyrony, Olivier, Monzó, Patricia, Lopera, Carlos, Gallardo-Pizarro, Antonio, Méndez, Raúl, Calbo, Esther, Xercavins, Mariona, Cuesta-Chasco, Genoveva, Martínez, José A., Marcos, Ma Angeles, Mensa, Josep, and Soriano, Alex

Published
2024
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4. Current microbiological testing approaches and documented infections at febrile neutropenia onset in patients with hematologic malignancies

Author

Chumbita Mariana, Peyrony Olivier, Teijón-Lumbreras Christian, Monzó-Gallo Patricia, Aiello Tommaso Francesco, Gallardo-Pizarro Antonio, Gras Emmanuelle, Puerta-Alcalde Pedro, Mateu Espasa, Martínez Carmen, Rivero Andrea, Casals-Pascual Climent, Soriano Alex, and Garcia-Vidal Carolina

Subjects
Febrile neutropenia, Epidemiology, Bacteremia, Hematologic patients, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: This study aims to identify infection etiology in febrile neutropenia (FN) is vital. This study explores different microbiological approaches and their impact on diagnosing infections in patients with hematologic malignancies and FN. Methods: This is a retrospective analysis conducted at the Hospital Clinic of Barcelona details microbiological testing strategies used to diagnose infections at FN onset between January 2020 and July 2022. Results: A total of 4520 microbiological tests were ordered in 462 FN episodes, achieving a 10% test positivity rate, with 200 (43.3%) episodes showing microbiological documentation of infection. Blood cultures (40.4%), non-culture blood tests (21.2%), and respiratory tract samples (16.2%) were the most requested. Blood cultures exhibited the highest (16.9%) test positivity rates, whereas non-culture blood tests showed the lowest (3.3%). Bacterial infections were present in 149 of 462 (32.3%) FN episodes. Viral infections (66 of 462, 14.3%)—notably, respiratory viruses—were also frequent. Mortality rate at 60 days was 9.1%; documented infections were associated with a higher risk (15%). Conclusions: In the current landscape of antimicrobial diagnostics, our findings revealed the highest reported rate of microbiologically documented infections at FN onset. Bacterial infections are common; however, our data reiterate the significance of viral infections in causing fever. Optimizing FN management during respiratory viral infections remains a challenge for antimicrobial de-escalation. The low positivity rates observed in certain diagnostic tests emphasize the need for cost-effective diagnostic stewardship.

Published
2024
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5. Safety and effectiveness of isavuconazole in real-life non-neutropenic patients

Author

Monzó-Gallo, Patricia, Lopera, Carlos, Badía-Tejero, Ana M, Machado, Marina, García-Rodríguez, Julio, Vidal-Cortés, Pablo, Merino, Esperanza, Calderón, Jorge, Fortún, Jesús, Palacios-Baena, Zaira R., Pemán, Javier, Sanchis, Joan Roig, Aguilar-Guisado, Manuela, Gudiol, Carlota, Ramos, Juan C, Sánchez-Romero, Isabel, Martin-Davila, Pilar, López-Cortés, Luis E., Salavert, Miguel, Ruiz-Camps, Isabel, Chumbita, Mariana, Aiello, Tommaso Francesco, Peyrony, Olivier, Puerta-Alcalde, Pedro, Soriano, Alex, Marco, Francesc, and Garcia-Vidal, Carolina

Published
2024
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6. Increasing of New CA-MRSA Infections Detected in people living with HIV Who Engage in Chemsex in Barcelona: An Ambispective Study

Author

De La Mora, Lorena, Pitart, Cristina, Morata, Laura, Ugarte, Ainoa, Martinez-Rebollar, María, De Lazzari, Elisa, Vergara, Andrea, Bosch, Jordi, Roca, Ignasi, Piquet, Maria, Rodriguez, Ana, Laguno, Montserrat, Ambrosioni, Juan, Torres, Berta, González-Cordón, Ana, Inciarte, Alexy, Foncillas, Alberto, Riera, Josep, Fuertes, Irene, Chivite, Iván, Martinez, Esteban, Blanco, José L., Soriano, Alex, and Mallolas, Josep

Published
2023
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7. Performance of an Autonomous Sanitary Sterilisation Ultraviolet Machine (ASSUM) on terminal disinfection of surgical theaters and rooms of an intensive-intermediate care unit

Author

Herrera, Sabina, Roca, Ignasi, Del Río, Ana, Fernández, Javier, Pitart, Cristina, Fortes, Isabel, Torralbo, Blanca, Santana, Gemina, Parejo-González, Romina, Veà-Baró, Andreu, Campistol, Josep Maria, Aguilar, Mireia, Degea, Sergi, Casals-Pascual, Climent, Soriano, Alex, and Martínez, José A.

Published
2024
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11. Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2

Author

Leal, Lorna, Pich, Judit, Ferrer, Laura, Nava, Jocelyn, Martí-Lluch, Ruth, Esteban, Ignasi, Pradenas, Edwards, Raïch-Regué, Dàlia, Prenafeta, Antoni, Escobar, Karla, Pastor, Carmen, Ribas-Aulinas, Marc, Trinitè, Benjamin, Muñoz-Basagoiti, Jordana, Domenech, Gemma, Clotet, Bonaventura, Corominas, Júlia, Corpes-Comes, Aida, Garriga, Carme, Barreiro, Antonio, Izquierdo-Useros, Nuria, Arnaiz, Joan Albert, Soriano, Alex, Ríos, José, Nadal, Marga, Plana, Montserrat, Blanco, Julià, Prat, Teresa, Torroella, Elia, and Ramos, Rafel

Published
2023
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12. Staphylococcus aureus surgical site infection rates in 5 European countries

Author

Mellinghoff, Sibylle C., Bruns, Caroline, Albertsmeier, Markus, Ankert, Juliane, Bernard, Louis, Budin, Sofia, Bataille, Camille, Classen, Annika Y., Cornely, Florian B., Couvé-Deacon, Elodie, Fernandez Ferrer, Maria, Fortún, Jesús, Galar, Alicia, Grill, Eva, Guimard, Thomas, Hampl, Jürgen A., Wingen-Heimann, Sebastian, Horcajada, Juan P., Köhler, Felix, Koll, Carolin, Mollar, Joan, Muñoz, Patricia, Pletz, Mathias W., Rutz, Jule, Salmanton-García, Jon, Seifert, Harald, Serracino-Inglott, Ferdinand, Soriano, Alex, Stemler, Jannik, Vehreschild, Janne J., Vilz, Tim O., Naendrup, Jan-Hendrik, Cornely, Oliver A., and Liss, Blasius J.

Published
2023
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16. Rezafungin versus Caspofungin in a Phase 2, Randomized, Double-Blind Study for the Treatment of Candidemia and Invasive Candidiasis- The STRIVE Trial

Author

Thompson, George R, Soriano, Alex, Skoutelis, Athanasios, Vazquez, Jose A, Honore, Patrick M, Horcajada, Juan P, Spapen, Herbert, Bassetti, Matteo, Ostrosky-Zeichner, Luis, Das, Anita F, Viani, Rolando M, Sandison, Taylor, and Pappas, Peter G

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Clinical Trials and Supportive Activities, Sepsis, Hematology, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adult, Antifungal Agents, Candidemia, Candidiasis, Invasive, Caspofungin, Double-Blind Method, Echinocandins, Humans, Treatment Outcome, echinocandins, rezafungin, candidemia, systemic antifungal therapy, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundRezafungin (RZF) is a novel echinocandin exhibiting distinctive pharmacokinetics/pharmacodynamics. STRIVE was a phase 2, double-blind, randomized trial designed to compare the safety and efficacy of RZF once weekly (QWk) to caspofungin (CAS) once daily for treatment of candidemia and/or invasive candidiasis (IC).MethodsAdults with systemic signs and mycological confirmation of candidemia and/or IC were randomized to RZF 400 mg QWk (400 mg), RZF 400 mg on week 1 then 200 mg QWk (400/200 mg), or CAS 70 mg as a loading dose followed by 50 mg daily for ≤4 weeks. Efficacy assessments included overall cure (resolution of signs of candidemia/IC + mycological eradication) at day 14 (primary endpoint), investigator-assessed clinical response at day 14, and 30-day all-cause mortality (ACM) (secondary endpoints), and time to negative blood culture. Safety was evaluated by adverse events and ACM through follow-up.ResultsOf 207 patients enrolled, 183 were in the microbiological intent-to-treat population (~21% IC). Overall cure rates were 60.5% (46/76) for RZF 400 mg, 76.1% (35/46) for RZF 400/200 mg, and 67.2% (41/61) for CAS; investigator-assessed clinical cure rates were 69.7% (53/76), 80.4% (37/46), and 70.5% (43/61), respectively. In total, 30-day ACM was 15.8% for RZF 400 mg, 4.4% for RZF 400/200 mg, and 13.1% for CAS. Candidemia was cleared in 19.5 and 22.8 hours in RZF and CAS patients, respectively. No concerning safety trends were observed; ACM through follow-up was 15.2% (21/138) for RZF and 18.8% (13/69) for CAS.ConclusionsRZF was safe and efficacious in the treatment of candidemia and/or IC.Clinical trials registrationNCT02734862.

Published
2021

17. The Use and Effectiveness of Ceftazidime–Avibactam in Real-World Clinical Practice: EZTEAM Study

Author

Soriano, Alex, Montravers, Philippe, Bassetti, Matteo, Klyasova, Galina, Daikos, George, Irani, Paurus, Stone, Gregory, Chambers, Richard, Peeters, Pascale, Shah, Mitesh, Hulin, Claire, Albuquerque, Natalia, Basin, Efim, Gaborit, Benjamin, Kourbeti, Irene, Menichetti, Francesco, Perez-Rodriguez, María Teresa, Pletz, Mathias W., Sanchez, Marisa, Trompa, Ivan, Verma, Anita, de Figueiredo, Maria Lavinea N., and Charbonneau, Claudie

Published
2023
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18. Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

Author

Frank, Bernhard J.H., Auñon, Alvaro, Morata, Laura, Birlutiu, Victoria, Storni, Elisa, Sorli, Luisa, Horcajada, Juan Pablo, Hamburger, Flávio Guinsburg, Salas Venero, Carlos, Pietro, Cimatti, Rondaan, Christien, Maso, Alessandra, Birlutiu, Rares-Mircea, Fernandez Sampedro, Marta, Soriano, Alex, Diaz de Brito, Vicens, Gómez Junyent, Joan, Del Toro, Maria Dolores, Hofstaetter, Jochen Gerhard, Salles, Mauro José, Esteban, Jaime, and Wouthuyzen-Bakker, Marjan

Published
2023
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19. Impact of adherence to individual quality-of-care indicators on the prognosis of bloodstream infection due to Staphylococcus aureus: a prospective observational multicentre cohort

Author

Escrihuela-Vidal, Francesc, Kaasch, Achim J., Von Cube, Maja, Rieg, Siegbert, Kern, Winfried V., Seifert, Harald, Song, Kyoung-Ho, Liao, Chun-Hsing, Tilley, Robert, Gott, Hannah, Scarborough, Matt, Gordon, Claire, Llewelyn, Martin J., Kuehl, Richard, Morata, Laura, Soriano, Alex, Edgeworth, Jonathan, De Gopegui, Enrique Ruiz, Nsutebu, Emmanuel, Cisneros, José Miguel, Fowler, Vance G., Thwaites, Guy, López-Contreras, Joaquín, Barlow, Gavin, Ternavasio-De La Vega, Hugo Guillermo, Rodríguez-Baño, Jesús, and López-Cortés, Luis Eduardo

Published
2023
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20. The Management of Patients at High Risk of Serious COVID-19 Disease: Optimising the Patient Pathway in the Middle East, Africa, and Eastern Europe

Author

Al-Salman, Jameela, primary, Amir, Ashraf, additional, Moore, Luke SP, additional, Poulakou, Garyphallia, additional, Soriano, Alex, additional, Abdallah, Jehad, additional, Abutidze, Akaki, additional, Amin, Wagdy, additional, El Assal, Gehan, additional, Nombulelo, Magula, additional, Tarawneh, Feras, additional, and Hassanien, Ashraf, additional

Published
2024
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21. Emergence of carbapenem-resistant Pseudomonas aeruginosa ST179 producing both IMP-16 and KPC-2: a case study of introduction from Peru to Spain

Author

Viñes, Joaquim, primary, Lopera, Carlos, additional, Vergara, Andrea, additional, Roca, Ignasi, additional, Vila, Jordi, additional, Casals-Pascual, Climent, additional, Martínez, José Antonio, additional, García-Vidal, Carolina, additional, Soriano, Alex, additional, and Pitart, Cristina, additional

Published
2024
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24. Clinical Presentation and Outcome of COVID-19 in a Latin American Versus Spanish Population: Matched Case-Control Study

Author

Alonso, Rodrigo, Camon, Ana M., Cardozo, Celia, Albiach, Laia, Agüero, Daiana, Marcos, M. Angeles, Ambrosioni, Juan, Bodro, Marta, Chumbita, Mariana, de la Mora, Lorena, Garcia-Pouton, Nicole, Dueñas, Gerard, Hernandez-Meneses, Marta, Inciarte, Alexy, Cuesta, Genoveva, Meira, Fernanda, Morata, Laura, Puerta-Alcalde, Pedro, Herrera, Sabina, Tuset, Montse, Castro, Pedro, Prieto-Gonzalez, Sergio, Mensa, Josep, Martínez, José Antonio, Sanjuan, Gemma, Nicolas, J. M., del Rio, A., Vila, Jordi, Garcia, Felipe, Garcia-Vidal, Carolina, and Soriano, Alex

Published
2022
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28. Bacterial co-infection at hospital admission in patients with COVID-19

Author

Moreno-García, Estela, Puerta-Alcalde, Pedro, Letona, Laura, Meira, Fernanda, Dueñas, Gerard, Chumbita, Mariana, Garcia-Pouton, Nicole, Monzó, Patricia, Lopera, Carlos, Serra, Laia, Cardozo, Celia, Hernandez-Meneses, Marta, Rico, Verónica, Bodro, Marta, Morata, Laura, Fernandez-Pittol, Mariana, Grafia, Ignacio, Castro, Pedro, Mensa, Josep, Martínez, José Antonio, Sanjuan, Gemma, Marcos, Mª Angeles, Soriano, Alex, and Garcia-Vidal, Carolina

Published
2022
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30. C-reactive protein cut-off for early tocilizumab and dexamethasone prescription in hospitalized patients with COVID-19

Author

Camon, Ana M., Alonso, Rodrigo, Muñoz, Francisco J., Cardozo, Celia, Bernal-Maurandi, Javier, Albiach, Laia, Agüero, Daiana, Marcos, M. Angeles, Ambrosioni, Juan, Bodro, Marta, Chumbita, Mariana, De la Mora, Lorena, Garcia-Pouton, Nicole, Dueñas, Gerard, Hernandez-Meneses, Marta, Inciarte, Alexy, Cuesta, Genoveva, Meira, Fernanda, Morata, Laura, Puerta-Alcalde, Pedro, Rico, Verónica, Herrera, Sabina, Tuset, Montse, Castro, Pedro, Prieto-González, Sergio, Almuedo, Alex, Muñoz, José, Mensa, Josep, Sanjuan, Gemma, Nicolas, J. M., Del Rio, Ana, Vila, Jordi, García, Felipe, Martínez, José Antonio, Garcia-Vidal, Carolina, and Soriano, Alex

Published
2022
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31. Chimeric Antigen Receptor T-Cell Postinfusion Fever: Infection Profile, Clinical Parameters, and Biomarkers Trends to Assist Antibiotic Stewardship.

Author

Peyrony, Olivier, Garcia-Pouton, Nicole, Chumbita, Mariana, Teijon-Lumbreras, Christian, Aiello, Tommaso Francesco, Monzó-Gallo, Patricia, Gallardo-Pizarro, Antonio, Ortiz-Maldonado, Valentín, Martinez-Cibrian, Núria, Delgado, Julio, Larrea, Carlos Fernandez de, Mensa, Josep, Puerta-Alcalde, Pedro, Soriano, Alex, and Garcia-Vidal, Carolina

Subjects
EARLY warning score, CHIMERIC antigen receptors, SYMPTOMS, BACTERIAL diseases, ANTIMICROBIAL stewardship
Abstract

Background This study aimed to describe documented infections associated with postinfusion fever after CAR T-cell therapy and to evaluate daily changes in vital signs, laboratory results, and the National Early Warning Score (NEWS) in patients with and without confirmed bacterial infections following fever onset, with the objective of assisting in antibiotic stewardship. Methods This was a retrospective, observational study including all consecutive adult patients who received CAR T-cell therapy. Documented infection in the first fever episode after infusion, and clinical and analytic trend comparison of patients with bacterial documented infections and those without documented infections, are described. Results Among 152 patients treated with CAR T-cell therapy, 87 (57.2%) had fever within 30 days of infusion, with a median time from infusion to fever of 3 (interquartile range, 2–5) days. Of these 87 patients, 82 (94.3%) received broad-spectrum antibiotics. Infection was documented in 9 (10.3%) patients and only 4 (4.6%) had bacterial infections. Clinical signs and biomarkers were similar in patients with bacterial documented infection and in those without documented infection at fever onset. Fever, tachycardia, and high C-reactive protein levels remained high during the first 3 days after CAR T-cell infusion, even when no infection was documented. Conclusions Fever is a common symptom following CAR T-cell infusion and is largely treated with broad-spectrum antibiotics. However, confirmed bacterial documented infections after the first fever post–CAR T-cell infusion are very unusual. Because clinical parameters and biomarkers are not useful for identifying infectious fever, other methods should be assessed to ensure the proper use of antibiotics. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Real-World Use and Treatment Outcomes of Ceftaroline Fosamil in Patients with Complicated Skin and Soft Tissue Infection: A Multinational Retrospective Study.

Author

Ferry, Tristan, Gogos, Charalambos, Soriano, Alex, Blasi, Francesco, Ansari, Wajeeha, Kantecki, Michal, Schweikert, Bernd, Luna, Gustavo, and Bassetti, Matteo

Subjects
CEFTAROLINE, LENGTH of stay in hospitals, SOFT tissue infections, COMMUNITY-acquired pneumonia, HOSPITAL costs, METHICILLIN-resistant staphylococcus aureus
Abstract

Background: Ceftaroline fosamil is approved for the treatment of complicated skin and soft tissue infections (cSSTI) and community-acquired pneumonia (CAP); however, data on its real-world use and effectiveness in Europe and Latin America are currently limited. This retrospective observational study assessed ceftaroline fosamil use and treatment outcomes in adults hospitalized with cSSTI or CAP treated with ceftaroline fosamil in a usual care setting in Europe and Latin America. Results for patients with cSSTI are reported. Methods: Data from patients with cSSTI who received ≥ 4 consecutive intravenous ceftaroline fosamil doses up to May 31, 2019, were collected from sites in Brazil, Colombia, France, Greece, Italy, and Spain. Patient characteristics, clinical management, hospitalization information, microbiological diagnosis, and clinical responses were summarized descriptively. Healthcare resource use variables were evaluated by clinical response to ceftaroline fosamil. Results: Data for 132 patients were included (58.3% male; mean age 58.5 years). Most common lesions were cellulitis/fasciitis (62.1%), abscess (34.1%), and post-surgical wounds (19.7%). Pathogens most frequently identified were methicillin-resistant (18.2%) and methicillin-susceptible Staphylococcus aureus (17.4%). Median (range) ceftaroline fosamil treatment duration was 8 (2– 60) days (daily doses of 1200 [400– 2400] mg); 78 patients (59.1%) received monotherapy. In total, 75 (56.8%) patients had additional antibiotics after ceftaroline fosamil. Clinical response occurred in 118 (89.4%) patients. All-cause 30-day readmission occurred in 13 (9.8%) patients, and all-cause 30-day mortality in 7 (5.3%). Clinical response to ceftaroline was associated with > 25% shorter length of hospital and intensive care stay, and with ~40% lower hospital costs, versus non-responders. Conclusion: Ceftaroline fosamil was effective in treating adults with cSSTI and clinical response to ceftaroline fosamil was associated with reductions in healthcare resource use compared with non-responders, in Europe and Latin America. Clinicaltrials.gov Identifier: NCT04198571. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Real‐Life Comparison of Antivirals for SARS‐CoV‐2 Omicron Infection in Patients With Hematologic Malignancies

Author

Aiello, Tommaso Francesco, primary, Peyrony, Olivier, additional, Chumbita, Mariana, additional, Monzó, Patricia, additional, Lopera, Carlos, additional, Puerta‐Alcalde, Pedro, additional, Magnano, Laura, additional, Fernández‐Avilés, Francesc, additional, Cuesta, Genoveva, additional, Tuset, Montse, additional, Mensa, Josep, additional, Esteve, Jordi, additional, Marcos, Maria Angeles, additional, Soriano, Alex, additional, and Garcia‐Vidal, Carolina, additional

Published
2024
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36. Should We Use Rifampicin in Periprosthetic Joint Infections Caused by Staphylococci When the Implant Has Been Exchanged? A Multicenter Observational Cohort Study

Author

Kramer, Tobias Siegfried, primary, Soriano, Alex, additional, Tedeschi, Sarah, additional, Chen, Antonia F, additional, Tattevin, Pierre, additional, Senneville, Eric, additional, Gomez-Junyent, Joan, additional, Birlutiu, Victoria, additional, Petersdorf, Sabine, additional, de Brito, Vicens Diaz, additional, Gonzalez, Ignacio Sancho, additional, Belden, Katherine A, additional, and Wouthuyzen-Bakker, Marjan, additional

Published
2024
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37. P29 Treatment outcomes with rezafungin and caspofungin in people aged 65 years and above with candidaemia and/or invasive candidiasis: integrated analysis of pooled Phase 2 and Phase 3 data

Author

Cornely, Oliver A, primary, Thompson, George R, additional, Soriano, Alex, additional, Kullberg, Bart-Jan, additional, Kollef, Marin, additional, Vazquez, Jose, additional, Honore, Patrick M, additional, Bassetti, Matteo, additional, Pullman, John, additional, Dignani, Cecilia, additional, Das, Anita F, additional, Sandison, Taylor, additional, and Pappas, Peter G, additional

Published
2024
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38. Impact of Inflammatory Response Modifiers on the Incidence of Hospital-Acquired Infections in Patients with COVID-19

Author

Meira, Fernanda, Moreno-García, Estela, Linares, Laura, Macaya, Irene, Tomé, Adria, Hernández-Meneses, Marta, Albiach, Laia, Morata, Laura, Letona, Laura, Bodro, Marta, Cózar-Llistó, Alberto, Cardozo, Celia, Chumbita, Mariana, Pitart, Cristina, Ambrosioni, Juan, Rico, Verónica, Agüero, Daiana, Puerta-Alcalde, Pedro, Garcia-Pouton, Nicole, Marco, Francesc, Garcia-Vidal, Carolina, Soriano, Alex, and Martínez, José Antonio

Published
2021
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40. Impact of low serum calcium at hospital admission on SARS-CoV-2 infection outcome

Author

Albiach, Laia, Agüero, Daiana, Ambrosioni, Juan, Bodro, Marta, Blanco, Jose Luis, De la Mora, Lorena, García-Alcaide, Felipe, García-Pouton, Nicole, Garcia-Vidal, Carolina, Hernández-Meneses, Marta, Laguno, Montserrat, Leal, Lorna, Linares, Laura, Macaya, Irene, Mallolas, Josep, Martínez, Esteban, Martínez-Rebollar, María, Miró, José María, Mensa, José, Moreno, Asunción, Moreno, Antonio, Moreno-García, Estela, Morata, Laura, Martínez, José Antonio, Puerta-Alcalde, Pedro, Rico, Verónica, Rojas, John, Solá, Montserrat, Torres, Manuel, Torres, Berta, Alcubilla, Pau, González-Cordón, Ana, Inciarte, Alexy, Chumbita, Mariana, Cardozo, Celia, Meira, Fernanda, Giménez, Marga, de Hollanda, Ana, and Soriano, Alex

Published
2021
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41. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study

Author

Rico, Verónica, Hernández-Meneses, Marta, Agüero, Daiana, Torres, Berta, González, Ana, de la Mora, Lorena, Rojas, Jhon, Linares, Laura, Fidalgo, Berta, Rodriguez, Natalia, Nicolas, David, Albiach, Laia, Muñoz, José, Almuedo, Alex, Camprubí, Daniel, Angeles Marcos, M<ce:sup loc='post">a</ce:sup>, Cilloniz, Catia, Fernández, Sara, Nicolas, Jose M., Torres, Antoni, Garcia-Vidal, Carolina, Sanjuan, Gemma, Moreno-García, Estela, Puerta-Alcalde, Pedro, Garcia-Pouton, Nicole, Chumbita, Mariana, Fernandez-Pittol, Mariana, Pitart, Cristina, Inciarte, Alexy, Bodro, Marta, Morata, Laura, Ambrosioni, Juan, Grafia, Ignacio, Meira, Fernanda, Macaya, Irene, Cardozo, Celia, Casals, Climent, Tellez, Adrian, Castro, Pedro, Marco, Francesc, García, Felipe, Mensa, Josep, Martínez, José Antonio, and Soriano, Alex

Published
2021
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42. Clinical Characteristics and Outcome of Bloodstream Infections in HIV-Infected Patients with Cancer and Febrile Neutropenia: A Case–Control Study

Author

Puerta-Alcalde, Pedro, Ambrosioni, Juan, Chumbita, Mariana, Hernández-Meneses, Marta, Garcia-Pouton, Nicole, Cardozo, Celia, Moreno-García, Estela, Marco, Francesc, Mensa, Josep, Rovira, Montserrat, Esteve, Jordi, Martínez, Jose A., García, Felipe, Mallolas, Josep, Soriano, Alex, Miró, José M., and Garcia-Vidal, Carolina

Published
2021
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44. Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

Author

Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, López, Juan Carlos, Ramírez-Schacke, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Parras, Francisco, Catalán, Pilar, García-Leoni, María E., Pérez-Tamayo, Isabel, Puente, Luis, Cedeño, Jamil, Berenguer, Juan, Díaz Menéndez, Marta, de la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, Lago Núñez, Mª del Mar, de Miguel Buckley, Rosa, Cadiñaños Loidi, Julen, Busca Arenzana, Carmen, Mican, Alfredo, Mora Rillo, Marta, Ramos Ramos, Juan Carlos, Loeches Yagüe, Belén, Bernardino de la Serna, José Ignacio, García Rodríguez, Julio, Arribas López, José Ramón, Such Diaz, Ana, Álvaro Alonso, Elena, Izquierdo García, Elsa, Torres Macho, Juan, Cuevas Tascon, Guillermo, Troya García, Jesús, Mestre Gómez, Beatriz, Jiménez González de Buitrago, Eva, Fernández Jiménez, Inés, Tebar Martínez, Ana Josefa, Brañas Baztán, Fátima, Valencia de la Rosa, Jorge, Pérez Butragueño, Mario, Alvarado Blasco, Marta, Ryan, Pablo, Sepúlveda Berrocal, Mª Antonia, Yera Bergua, Carmen, Toledano Sierra, Pilar, Cano Llorente, Verónica, Zafar Iqubal-Mirza, Sadaf, Muñiz, Gema, Martín Pérez, Inmaculada, Mozas Moriñigo, Helena, Alguacil, Ana, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Goikoetxea Agirre, Josune, Blanco Vidal, María José, Nieto Arana, Javier, del Álamo Martínez de Lagos, Mikel, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Silvariño Fernández, Rafael, Ugalde Espiñeira, Jon, Asensi Álvarez, Víctor, Suárez Pérez, Lucia, Suárez Diaz, Silvia, Yllera Gutiérrez, Carmen, Boix, Vicente, Díez Martínez, Marcos, Carreres Candela, Melissa, Gómez-Ayerbe, Cristina, Sánchez-Lora, Javier, Velasco Garrido, José Luis, López-Jódar, María, Santos González, Jesús, Ruiz Aragón, Jesús, Virto Peña, Ianire, Alende Castro, Vanessa, Brea Aparicio, Ruth, Vega Molpeceres, Sonia, Pons Viñas, Estel, del Río Pérez, Oscar, Valero Rovira, Silvia, Villar-García, Judit, Gómez-Junyent, Joan, Knobel, Hernando, Cánepa, María Cecilia, Castañeda Espinosa, Silvia, Sorli Redò, Luisa, Güerri-Fernández, Roberto, Milagro Montero, María, Horcajada, Juan Pablo, García Vázquez, Elisa, Moral Escudero, Encarnación, Hernández Torres, Alicia, García Almodóvar, Esther, Sáez Barberá, Carmen, Karroud, Zineb, Hernández Quero, José, Vinuesa García, David, García Fogeda, José Luis, Peregrina, José Antonio, Novella Mena, María, Hernández Gutiérrez, Cristina, Sanz Moreno, José, Pérez Tanoira, Ramón, Sierra Rodríguez, Rodrigo, Alonso Menchén, David, Gutiérrez García, Aida, Arranz Caso, Alberto, Cuadros González, Juan, Álvarez de Mon Soto, Melchor, Díaz de Brito Fernández, Vicente Ferrer, Sanmarti Vilamala, Montserrat, Gabarrell Pascuet, Aina, Molina Morant, Daniel, España Cueto, Sergio, Cámara Fernández, Jonathan, Sabater Gil, Albert, Muñoz López, Laura, Sáez Escolano, Paula, Bejarano Tello, Esperanza, Sempere Alcocer, Marco Antonio, Álvarez Martin, Salvador, De los Santos Gil, Ignacio, García-Fraile, Lucio, Sampedro Núñez, Miguel, Barrios Blandino, Ana, Rodríguez Franco, Carlos, Useros Brañas, Daniel, Villa Martí, Almudena, Oliver Ortega, Javier, Costanza Espiño Álvarez, Alexia, Sanz Sanz, Jesús, Rexach Fumaña, María, Abascal Cambras, Ivette, Pérez Jaén, Ana del Cielo, Sala Jofre, Clara, Casas Rodríguez, Susana, Tortajada Alamilla, Cecilia, Oltra, Carmina, Masiá Canuto, Mar, Gutiérrez Rodero, Félix, Ferrer Ribera, Ana, Bea Serrano, Carlos, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, Fiorante, Silvana, Pérez Pinto, Sergio, Hernández Machín, Pilar, Alastrué Violeta, Alba, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Gozalo, Mónica, Mora Gómez, Francisco, Milagro Beamonte, Ana, Latorre-Millán, Miriam, Rezusta López, Antonio, Martínez Sapiña, Ana, Meije, Yolanda, Duarte Borges, Alejandra, Pareja Coca, Julia, Clemente Presas, Mercedes, Losa García, Juan Emilio, Vegas Serrano, Ana, Pérez-Rodríguez, M. Teresa, Pérez González, Alexandre, Belhassen-García, Moncef, Rodríguez-Alonso, Beatriz, López-Bernus, Amparo, Carbonell, Cristina, Torres Perea, Rafael, Cantón de Seoane, Juan, Alonso, Blanca, Kamal, Sara Lidia, Cajuela, Lucia, Roa, David, Cervero, Miguel, Oreja, Alberto, Avilés, Juan Pablo, Martín, Lidia, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Abadia Otero, Jessica, Salillas Hernando, Juan, Torres Sánchez del Arco, Robert, Torralba González de Suso, Miguel, Serrano Martínez, Alberto, Gilaberte Reyzábal, Sergio, Pacheco Martínez-Atienza, Marina, Liébana Gómez, Mónica, Fernández Rodríguez, Sara, Varela Plaza, Álvaro, Calvo Sánchez, Henar, Martínez Martín, Patricia, González- Ruano, Patricia, Malmierca Corral, Eduardo, Rábago Lorite, Isabel, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Sirisi, Merce, Rojas, Richard, Díaz de Tuesta del Arco, José Luis, Figueroa Cerón, Ruth, González Sarria, Ander, Alemán Valls, Remedios, Alonso Socas, María del Mar, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Riera Jaume, Melchor, Vilchez, Helem Haydee, Albertí, Francesc, Cañabate, Ana Isabel, Moreno Cuerda, Víctor J., Álvarez Kaelis, Silvia, Álvarez Zapatero, Beatriz, García García, Alejandro, Isaba Ares, Elena, Morcate Fernández, Covadonga, Pérez Rodríguez, Andrea, Ramos Merino, Lucía, Castelo Corral, Laura, Rodríguez Mahía, María, González Bardanca, Mónica, Sánchez Vidal, Efrén, Míguez Rey, Enrique, De la Torre Lima, Javier, García de Lomas Guerrero, José Mª, Morte, Elena, Loscos, Silvia, Camón, Ana, Gómez García, Lucía, Boix Palop, Lucia, Dietl Gómez-Luengo, Beatriz, Pedrola Gorrea, Iris, Blasco Claramunt, Amparo, López Mestanza, Cristina, Fraile Villarejo, Esther, Tosco Núñez, Tomás, Aroca Ferri, María, Algado Rabasa, José Tomas, Garijo Saiz, Ana María, Amador Prous, Concepción, Baño, Jesús Rodriguez, Retamar, Pilar, Valiente, Adoración, López-Cortés, Luis E., Sojo, Jesús, Gutiérrez-Gutiérrez, Belén, Bravo-Ferrer, José, Salamanca, Elena, Palacios, Zaira R., Pérez-Palacios, Patricia, Peral, Enrique, Pérez de León, José Antonio, Sánchez-Gómez, Jesús, Marín-Barrera, Lucía, García-Jiménez, Domingo, Carratalà, Jordi, Abelenda-Alonso, Gabriela, Ardanuy, Carmen, Bergas, Alba, Cuervo, Guillermo, Domínguez, María Ángeles, Fernández-Huerta, Miguel, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Pérez-Recio, Sandra, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Trullen, Núria, Salavert Lletí, Miguel, Castro Hernández, Iván, Hernández Belmonte, Adriana, Martínez Goñi, Raquel, Navarro Vilasaró, Marta, Calzado Isbert, Sonia, Cervantes García, Manuel, Gomila Grange, Aina, Gasch Blasi, Oriol, Machado Sicilia, María Luisa, Van den Eynde Otero, Eva, Falgueras López, Luis, Navarro Sáez, María del Carmen, Martínez, Esteban, Marcos, Mª Ángeles, Mosquera, Mar, Blanco, José Luis, Laguno, Montserrat, Rojas, Jhon, González-Cordón, Ana, Inciarte, Alexy, Torres, Berta, De la Mora, Lorena, Soriano, Alex, Martínez Macias, Olalla, Pérez Doñate, Virginia, Cabello Úbeda, Alfonso, Carrasco Antón, Nerea, Álvarez Álvarez, Beatriz, Petkova Saiz, Elizabet, Górgolas Hernández-Mora, Miguel, Prieto Pérez, Laura, Carrillo Acosta, Irene, Heili Frades, Sara, Villar Álvarez, Felipe, Fernández Roblas, Ricardo, Milicua Muñoz, José María, Fernández Espinilla, Virginia, Dueñas Gutiérrez, Carlos Jesús, Hernán García, Cristina, González-Romo, Fernando, Merino Amador, Paloma, Rueda López, Alba, Martínez Jordán, Jorge, Medrano Pardo, Sara, Díaz de la Torre, Irene, Posada Franco, Yolanda, Delgado-Iribarren, Alberto, López-Contreras González, Joaquín, Pascual Alonso, Pablo, Pomar Solchaga, Virginia, Rabella García, Nuria, Benito Hernández, Natividad, Domingo Pedrol, Pere, Bonfill Cosp, Xavier, Padrós Selma, Rafael, Puig Campmany, Mireia, Mancebo Cortés, Jordi, Gurguí Ferrer, Mercè, Íñigo Pestaña, Melania, Pérez García, Alejandra, Sorní Moreno, Patricia, Izko Gartzia, Nora, Membrillo de Novales, Francisco Javier, Simón Sacristán, María, Zamora Cintas, Maribel, Martínez Martínez, Yolanda, Fernández-González, Pablo, Alcántara Nicolás, Francisco, Aguirre Vila-Cora, Alejandro, López Tizón, Elena, Ramírez-Olivencia, Germán, Estébanez Muñoz, Miriam, Sáez de Adana Arróniz, Ester, Portu Zapirain, Joseba, Gainzarain Arana, Juan Carlos, Ortiz de Zárate Ibarra, Zuriñe, Moran Rodríguez, Miguel Ángel, Canut Blasco, Andrés, Hernáez Crespo, Silvia, Balerdi Sarasola, Leire, Morales García, Cristina, Corral Saracho, Miguel, Valcarce González, Zeltia, Arenal Andrés, Noelia, Rodríguez Tarazona, Raquel Elisa, Iglesias Llorente, Laura, Loureiro Rodríguez, Beatriz, Sánchez Montalvá, Adrián, Espinosa Pereiro, Juan, Almirante, Benito, Miarons, Marta, Sellarés, Júlia, Larrosa, María, García, Sonia, Marzo, Blanca, Villamarín, Miguel, Fernández, Nuria, Pérez-Jorge Peremarch, Conchita, Resino Foz, Elena, Espigares Correa, Andrea, Álvarez de Espejo Montiel, Teresa, Navas Clemente, Iván, Quijano Contreras, María Isabel, Nieto Fernández del Campo, Luis Alberto, Jiménez Álvarez, Guillermo, Guillamón Sánchez, Mercedes, García García, Josefina, Muñoz Hornero, Constanza, Mariño Callejo, Ana, Valcarce Pardeiro, Nieves, Smithson Amat, Alex, Chico Chumillas, Cristina, Sánchez Serrano, Adriana, García Villalba, Eva Pilar, Jiménez Martínez, Isabel, Estrada Fernández, Guillermo, Lorén Vargas, María, Parra Arribas, Nuria, Martínez Cilleros, Carmen, Villasante de la Puente, Aránzazu, García Delange, Teresa, Ruiz Rodríguez, María José, Robledo del Prado, Marta, Abad Almendro, Juan Carlos, Muñoz del Rey, José Román, Jiménez Álvaro, Montaña, Coy Coy, Javier, Poquet Catala, Inmaculada, Santos Peña, Marta, Naranjo Velasco, Virginia, Manso Gómez, Tamara, Quilez Ágreda, Delia, Barbeito Castiñeiras, Gema, Domínguez Santalla, María Jesús, Mao Martín, Laura, Alonso Navarro, Rodrigo, Ampuero Martinich, Jose David, Barrós González, Raquel, Galindo Martín, María Aránzazu, Herrera Pacheco, Lourdes, Martínez Avilés, Rocío, Rodrigo González, Sara, Rodríguez Leal, Cristóbal Manuel, Romay Lema, Eva María, Suárez Gil, Roi, Ibarguren Pinilla, Maialen, Marimón Ortiz de Zárate, José María, Vidaur Tello, Loreto, Kortajarena Urkola, Xabier, García Gómez, Miriam, Aranguren Arostegui, Asier, Álvarez de Castro, Maria, Martínez Mateu, Cintia María, Rodríguez Gómez, Francisco, Muñoz Beamud, Francisco, Chamarro Martí, Elena, Cardona Rivera, Merce, Zakariya-Yousef Breval, Ismail, Rico Rodríguez, Marta, Llenas García, Jara, Sánchez Arenas, Mª Carmen, Fernández Cruz, Ana, Calderón Parra, Jorge, López Dosil, Marcos, Ramos Martínez, Antonio, Múñez Rubio, Elena, Callejas Díaz, Alejandro, Vázquez Comendador, José Manuel, Diego Yagüe, Itziar, Expósito Palomo, Esther, Anel Pedroche, Jorge, Álvarez Franco, Raquel, Fernández de Orueta, Lucía, Vates Gómez, Roberto, Cardona Arias, Andrés Felipe, Marguenda Contreras, Pablo, Gaspar Alonso-Vega, Gabriel, Aranda Rife, Elena María, Martínez Cifre, Blanca, Roger Zapata, Daniel, Martín Rubio, Irene, Barbosa Ventura, André, Piñero, Iván, Bahamonde Carrasco, Alberto, Runza Buznego, Paula, Talavera García, Eva, Lamata Subero, Marta, Urrutia Losada, Ainhoa, Arteche Eguizabal, Lorea, Delgado Sánchez, Elisabet, Molina Peinado, Virginia, Caro Bragado, Sarah, Domínguez de Pablos, Gema, Roldán Fontana, Carolina, Herrero Rodríguez, Carmen, Force Sanmartín, Luis, Aranega, Raquel, Mera Fidalgo, Arantzazu, Toda Savall, María Roca, Merchante Gutiérrez, Nicolas, León Jiménez, Eva María, Del Pozo, José Luís, Serralta Buades, Josefa, Cabrera Tejada, Ginger Giorgiana, Fernández-Ruiz, Mario, Aguado, José María, Maestro de la Calle, Guillermo, Cisneros, José Miguel, Pachón, Jerónimo, Aguilar-Guisado, Manuela, Aldabó, Teresa, Avilés, María Dolores, Bueno, Claudio, Cordero-Matía, Elisa, Escoresca, Ana, Gálvez-Benítez, Lydia, Infante, Carmen, Martín, Guillermo, Praena, Julia, Roca, Cristina, Salamanca, Celia, Suárez-Benjumea, Alejandro, Vizcarra, Pilar, Quereda, Carmen, Rodriguez Dominguez, Mario José, Gioia, Francesca, Norman, Francesca, Del Campo, Santos, Cantón Moreno, Rafael, Oteo Revuelta José, Antonio, Santibáñez Sáenz, Paula, Cervera Acedo, Cristina, Ruiz Martínez, Carlos, Blanco Ramos, José R., Azcona Gutiérrez, José M., García García, Concepción, Alba Fernández, Jorge, Ibarra Cucalón, Valvanera, San Franco, Mercedes, Metola Sacristán, Luis, Meijide Míguez, Héctor, Paulos Viñas, Silvia, Menéndez, Justo, Villares Fernández, Paula, Montes Andújar, Lara, Navarro Batet, Álvaro, Ferrer Santolaria, Anna, Padilla Salazar, María de la Luz, Abella Vázquez, Lucy, Hayek Peraza, Marcelino, García Pardo, Antonio, Hernández Carballo, Carolina, Ruiz Fernández, Andrés Javier, Barrio López, Isabel, Martakoush, Alí, Rojas-Vieyra, Agustín, García Calvo, Sonia, Villarreal García-Lomas, Mercedes, Vizcaíno Callejón, Marta, García García, María Pilar, Lérida Urteaga, Ana, Carrasco Fons, Natalia, María Sanjuan, Beatriz, Martín González, Lydia, Sanz Zamudio, Camilo, Jarrín, Inmaculada, Alejos, Belén, Moreno, Cristina, Rava, Marta, Iniesta, Carlos, Izquierdo, Rebeca, Suárez-García, Inés, Díaz, Asunción, Ruiz-Alguero, Marta, Hernando, Victoria, Rodríguez-Baño, Jesús, Yllescas, María, and Arriba, José Ramón

Published
2020
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46. Role of Routine Suppressive Antibiotic Therapy After Debridement, Antibiotics, and Implant Retention for Acute Periprosthetic Joint Infections.

Author

Tai, Don Bambino Geno, Tande, Aaron J, Langworthy, Benjamin, Abdel, Matthew P, Berbari, Elie F, Have, Bas ten, Jutte, Paul, Soriano, Alex, Suh, Gina A, Zijlstra, Wierd, and Wouthuyzen-Bakker, Marjan

Subjects
PROSTHESIS-related infections, DEBRIDEMENT, TREATMENT failure, RANDOMIZED controlled trials, ANTIBIOTICS
Abstract

Background The first-line management strategy for acute periprosthetic joint infections (PJIs) is debridement, antibiotics, and implant retention (DAIR). Suppressive antibiotic therapy (SAT) after DAIR is proposed to improve outcomes, yet its efficacy remains under scrutiny. Methods We conducted a multicenter retrospective study in patients with acute PJI of the hip or knee who were treated with DAIR in centers from Europe and the United States. We analyzed the effect of SAT using a Cox model landmarked at 12 weeks. The primary covariate of interest was SAT, which was analyzed as a time-varying covariate. Patients who experienced treatment failure or were lost to follow-up within 12 weeks were excluded from the analysis. Results The study included 510 patients with 66 treatment failures with a median follow-up of 801 days. We did not find a statistically significant association between SAT and treatment failure (hazard ratio, 1.37; 95% CI,.79–2.39; P =.27). Subgroup analyses for joint, country cohort, and type of infection (early or late acute) did not show benefit for SAT. Secondary analysis of country cohorts showed a trend toward benefit for the US cohort (hazard ratio, 0.36; 95% CI,.11–1.15; P =.09), which also had the highest risk of treatment failure. Conclusions The utility of routine SAT as a strategy for enhancing DAIR's success in acute PJI remains uncertain. Our results suggest that SAT's benefits might be restricted to specific groups of patients, underscoring the need for randomized controlled trials. Identifying patients most likely to benefit from SAT should be a priority in future studies. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Early detection of deterioration in COVID-19 patients by continuous ward respiratory rate monitoring: a pilot prospective cohort study

Author

Rivas, Eva, primary, López-Baamonde, Manuel, additional, Sanahuja, Josep, additional, Del Rio, Elena, additional, Ramis, Tomeu, additional, Recasens, Anna, additional, López, Antonio, additional, Arias, Marilyn, additional, Kampakis, Stylianos, additional, Lauteslager, Timo, additional, Awara, Osama, additional, Mascha, Edward J., additional, Soriano, Alex, additional, Badía, Joan Ramon, additional, Castro, Pedro, additional, and Sessler, Daniel I., additional

Published
2023
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49. Reply to Paranhos-Baccalà et al. Comment on "Cuesta et al. An Assessment of a New Rapid Multiplex PCR Assay for the Diagnosis of Meningoencephalitis. Diagnostics 2024, 14 , 802".

Author

Cuesta, Genoveva, Puerta-Alcalde, Pedro, Vergara, Andrea, Roses, Enric, Bosch, Jordi, Casals-Pascual, Climent, Soriano, Alex, Marcos, Maria Ángeles, Sanz, Sergi, and Vila, Jordi

Subjects
WERNICKE'S encephalopathy, CEREBROSPINAL fluid, SUBARACHNOID hemorrhage, IMMUNOCOMPROMISED patients, ENCEPHALITIS
Abstract

This document is a reply to a comment made by Paranhos-Baccalà et al. regarding a recent article published in the journal Diagnostics. The authors of the reply acknowledge the sensitivity controversy surrounding the Biofire Filmarray ME panel, specifically in relation to HSV-1. They discuss the limitations of their study and address concerns raised by Paranhos-Baccalà et al. regarding the representativeness of the samples studied. The authors emphasize the importance of clinical correlation in the diagnosis of meningoencephalitis and suggest that larger comparative studies are needed to confirm their findings. [Extracted from the article]

Published
2024
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