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2. S-Nitrosylation of Ras Mediates Nitric Oxide-Dependent Post-Injury Neurogenesis in a Seizure Model

Author

Santos, Ana Isabel, Pereira Carreira, Bruno, Izquierdo-Álvarez, Alicia, Ramos, Elena, Lourenço, Ana Sofia, Santos, Daniela Filipa, Morte, Maria Inês, Ribeiro, Luís Filipe, Marreiros, Ana, Sánchez-López, Nuria, Marina, Anabel, Monteiro Carvalho, Caetana, Martínez Ruiz, Antonio, Araújo, Inês Maria, Santos, Ana Isabel, Pereira Carreira, Bruno, Izquierdo-Álvarez, Alicia, Ramos, Elena, Lourenço, Ana Sofia, Santos, Daniela Filipa, Morte, Maria Inês, Ribeiro, Luís Filipe, Marreiros, Ana, Sánchez-López, Nuria, Marina, Anabel, Monteiro Carvalho, Caetana, Martínez Ruiz, Antonio, and Araújo, Inês Maria

Abstract

Aims: Nitric oxide (NO) is involved in the upregulation of endogenous neurogenesis in the subventricular zone and in the hippocampus after injury. One of the main neurogenic pathways activated by NO is the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway, downstream of the epidermal growth factor receptor. However, the mechanism by which NO stimulates cell proliferation through activation of the ERK/MAPK pathway remains unknown, although p21Ras seems to be one of the earliest targets of NO. Here, we aimed at studying the possible neurogenic action of NO by posttranslational modification of p21Ras as a relevant target for early neurogenic events promoted by NO in neural stem cells (NSCs). Results: We show that NO caused S-nitrosylation (SNO) of p21Ras in Cys118, which triggered downstream activation of the ERK/MAPK pathway and proliferation of NSC. Moreover, in cells overexpressing a mutant Ras in which Cys118 was replaced by a serine–C118S–, cells were insensitive to NO, and no increase in SNO, in ERK phosphorylation, or in cell proliferation was observed. We also show that, after seizures, in the presence of NO derived from inducible nitric oxide synthase, there was an increase in p21Ras cysteine modification that was concomitant with the previously described stimulation of proliferation in the dentate gyrus. Innovation: Our work identifies p21Ras and its SNO as an early target of NO during signaling events that lead to NSC proliferation and neurogenesis. Conclusion: Our data highlight Ras SNO as an early event leading to NSC proliferation, and they may provide a target for NO-induced stimulation of neurogenesis with implications for brain repair, Foundation for Science and Technology, ISCIII, Spanish Government, partially funded by FEDER/ EDRF, Depto. de Bioquímica y Biología Molecular, Fac. de Farmacia, TRUE, pub

Published
2024

4. Crown-Level Structure and Fuel Load Characterization from Airborne and Terrestrial Laser Scanning in a Longleaf Pine (Pinus palustris Mill.) Forest Ecosystem

Author

Rocha, Kleydson Diego, primary, Silva, Carlos Alberto, additional, Cosenza, Diogo N., additional, Mohan, Midhun, additional, Klauberg, Carine, additional, Schlickmann, Monique Bohora, additional, Xia, Jinyi, additional, Leite, Rodrigo V., additional, Almeida, Danilo Roberti Alves de, additional, Atkins, Jeff W., additional, Cardil, Adrian, additional, Rowell, Eric, additional, Parsons, Russ, additional, Sánchez-López, Nuria, additional, Prichard, Susan J., additional, and Hudak, Andrew T., additional

Published
2023
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5. Hacking Limnology Workshop and DSOS22: Creating a Community of Practice for the Nexus of Data Science, Open Science, and the Aquatic Sciences

Author

Meyer, Michael F., primary, Barbosa, Carolina C., additional, Ladwig, Robert, additional, Mesman, Jorrit P., additional, Börekçi, Nahit Soner, additional, Cawley, Kaelin, additional, Feldbauer, Johannes, additional, Oleksy, Isabella A., additional, Pilla, Rachel M., additional, Tran, Patricia Q., additional, Zwart, Jacob A., additional, Schnedler‐Meyer, Nicolas Azaña, additional, Andersen, Tobias K., additional, Brousil, Matthew R., additional, Fickas, Kate C., additional, Filazzola, Alessandro, additional, King, Tyler V., additional, Sánchez‐López, Nuria, additional, Stengel, Victoria, additional, and Trolle, Dennis, additional

Published
2022
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6. Hacking Limnology Workshop and DSOS22 : Creating a Community of Practice for the Nexus of Data Science, Open Science, and the Aquatic Sciences

Author

Meyer, Michael F., Barbosa, Carolina C., Ladwig, Robert, Mesman, Jorrit P., Börekçi, Nahit Soner, Cawley, Kaelin, Feldbauer, Johannes, Oleksy, Isabella A., Pilla, Rachel M., Tran, Patricia Q., Zwart, Jacob A., Schnedler‐Meyer, Nicolas Azaña, Andersen, Tobias K., Brousil, Matthew R., Fickas, Kate C., Filazzola, Alessandro, King, Tyler V., Sánchez‐López, Nuria, Stengel, Victoria, Trolle, Dennis, Meyer, Michael F., Barbosa, Carolina C., Ladwig, Robert, Mesman, Jorrit P., Börekçi, Nahit Soner, Cawley, Kaelin, Feldbauer, Johannes, Oleksy, Isabella A., Pilla, Rachel M., Tran, Patricia Q., Zwart, Jacob A., Schnedler‐Meyer, Nicolas Azaña, Andersen, Tobias K., Brousil, Matthew R., Fickas, Kate C., Filazzola, Alessandro, King, Tyler V., Sánchez‐López, Nuria, Stengel, Victoria, and Trolle, Dennis

Published
2022
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7. S-Nitrosation of E3 Ubiquitin Ligase Complex Components Regulates Hormonal Signalings in Arabidopsis

Author

Terrile, Maria Cecilia, primary, Tebez, Nuria Malena, additional, Colman, Silvana Lorena, additional, Mateos, Julieta Lisa, additional, Morato-López, Esperanza, additional, Sánchez-López, Nuria, additional, Izquierdo-Álvarez, Alicia, additional, Marina, Anabel, additional, Calderón Villalobos, Luz Irina A., additional, Estelle, Mark, additional, Martínez-Ruiz, Antonio, additional, Fiol, Diego Fernando, additional, Casalongué, Claudia Anahí, additional, and Iglesias, María José, additional

Published
2022
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8. The AEMON‐J “Hacking Limnology” Workshop Series & Virtual Summit: Incorporating Data Science and Open Science in Aquatic Research

Author

Meyer, Michael F., primary, Ladwig, Robert, additional, Mesman, Jorrit P., additional, Oleksy, Isabella A., additional, Barbosa, Carolina C., additional, Cawley, Kaelin M., additional, Cramer, Alli N., additional, Feldbauer, Johannes, additional, Tran, Patricia Q., additional, Zwart, Jacob A., additional, López Moreira M., Gregorio A., additional, Shikhani, Muhammed, additional, Gurung, Deviyani, additional, Hensley, Robert T., additional, Matta, Elena, additional, McClure, Ryan P., additional, Petzoldt, Thomas, additional, Sánchez‐López, Nuria, additional, Soetaert, Karline, additional, Thomas, Mridul K., additional, Topp, Simon N., additional, and Yang, Xiao, additional

Published
2021
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9. The AEMON-J “Hacking Limnology” Workshop Series & Virtual Summit : Incorporating Data Science and Open Science in Aquatic Research

Author

Meyer, Michael F., Ladwig, Robert, Mesman, Jorrit P., Oleksy, Isabella A., Barbosa, Carolina C., Cawley, Kaelin M., Cramer, Alli N., Feldbauer, Johannes, Tran, Patricia Q., Zwart, Jacob A., López Moreira M., Gregorio A., Shikhani, Muhammed, Gurung, Deviyani, Hensley, Robert T., Matta, Elena, McClure, Ryan P., Petzoldt, Thomas, Sánchez-López, Nuria, Soetaert, Karline, Thomas, Mridul K., Topp, Simon N., Yang, Xiao, Meyer, Michael F., Ladwig, Robert, Mesman, Jorrit P., Oleksy, Isabella A., Barbosa, Carolina C., Cawley, Kaelin M., Cramer, Alli N., Feldbauer, Johannes, Tran, Patricia Q., Zwart, Jacob A., López Moreira M., Gregorio A., Shikhani, Muhammed, Gurung, Deviyani, Hensley, Robert T., Matta, Elena, McClure, Ryan P., Petzoldt, Thomas, Sánchez-López, Nuria, Soetaert, Karline, Thomas, Mridul K., Topp, Simon N., and Yang, Xiao

Published
2021
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10. The AEMON‐J“Hacking Limnology” Workshop Series & Virtual Summit: Incorporating Data Science and Open Science in Aquatic Research

Author

Meyer, Michael F., Ladwig, Robert, Mesman, Jorrit P., Oleksy, Isabella A., Barbosa, Carolina C., Cawley, Kaelin M., Cramer, Alli N., Feldbauer, Johannes, Tran, Patricia Q., Zwart, Jacob A., López Moreira M., Gregorio A., Shikhani, Muhammed, Gurung, Deviyani, Hensley, Robert T., Matta, Elena, McClure, Ryan P., Petzoldt, Thomas, Sánchez‐López, Nuria, Soetaert, Karline, Thomas, Mridul K., Topp, Simon N., and Yang, Xiao

Published
2021
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11. Regulation of SCFTIR1/AFBs E3 ligase assembly by S-nitrosylation of Arabidopsis SKP1-like1 impacts on auxin signaling

Author

Iglesias, María José, primary, Terrile, María Cecilia, additional, Correa-Aragunde, Natalia, additional, Colman, Silvana Lorena, additional, Izquierdo-Álvarez, Alicia, additional, Fiol, Diego Fernando, additional, París, Ramiro, additional, Sánchez-López, Nuria, additional, Marina, Anabel, additional, Calderón Villalobos, Luz Irina A., additional, Estelle, Mark, additional, Lamattina, Lorenzo, additional, Martínez-Ruiz, Antonio, additional, and Casalongué, Claudia Anahí, additional

Published
2018
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12. Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia

Author

European Commission, Fundación Domingo Martínez, Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Universidad Autónoma de Madrid, Hernansanz-Agustín, Pablo, Ramos, Elena, Navarro, Elisa, Parada, Esther, Sánchez-López, Nuria, Peláez-Aguado, Laura, Cabrera-García, Daniel J., Tello, Daniel, Buendía Abaitua, Izaskun, Marina, Anabel, Egea Maiquez, Javier, López, Manuela G., Bogdanova, Anna, Martínez-Ruiz, Antonio, European Commission, Fundación Domingo Martínez, Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Universidad Autónoma de Madrid, Hernansanz-Agustín, Pablo, Ramos, Elena, Navarro, Elisa, Parada, Esther, Sánchez-López, Nuria, Peláez-Aguado, Laura, Cabrera-García, Daniel J., Tello, Daniel, Buendía Abaitua, Izaskun, Marina, Anabel, Egea Maiquez, Javier, López, Manuela G., Bogdanova, Anna, and Martínez-Ruiz, Antonio

Abstract

Mitochondria use oxygen as the final acceptor of the respiratory chain, but its incomplete reduction can also produce reactive oxygen species (ROS), especially superoxide. Acute hypoxia produces a superoxide burst in different cell types, but the triggering mechanism is still unknown. Herein, we show that complex I is involved in this superoxide burst under acute hypoxia in endothelial cells. We have also studied the possible mechanisms by which complex I could be involved in this burst, discarding reverse electron transport in complex I and the implication of PTEN-induced putative kinase 1 (PINK1). We show that complex I transition from the active to ‘deactive’ form is enhanced by acute hypoxia in endothelial cells and brain tissue, and we suggest that it can trigger ROS production through its Na/H antiporter activity. These results highlight the role of complex I as a key actor in redox signalling in acute hypoxia.

Published
2017

13. Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia

Author

Hernansanz-Agustín, Pablo, Ramos, Elena, Navarro, Elisa, Parada, Esther, Sánchez-López, Nuria, Peláez-Aguado, Laura, Cabrera-García, J Daniel, Tello, Daniel, Buendia, Izaskun, Marina, Anabel, Egea, Javier, López, Manuela G, Bogdanova, Anna, Martínez-Ruiz, Antonio, Hernansanz-Agustín, Pablo, Ramos, Elena, Navarro, Elisa, Parada, Esther, Sánchez-López, Nuria, Peláez-Aguado, Laura, Cabrera-García, J Daniel, Tello, Daniel, Buendia, Izaskun, Marina, Anabel, Egea, Javier, López, Manuela G, Bogdanova, Anna, and Martínez-Ruiz, Antonio

Abstract

Mitochondria use oxygen as the final acceptor of the respiratory chain, but its incomplete reduction can also produce reactive oxygen species (ROS), especially superoxide. Acute hypoxia produces a superoxide burst in different cell types, but the triggering mechanism is still unknown. Herein, we show that complex I is involved in this superoxide burst under acute hypoxia in endothelial cells. We have also studied the possible mechanisms by which complex I could be involved in this burst, discarding reverse electron transport in complex I and the implication of PTEN-induced putative kinase 1 (PINK1). We show that complex I transition from the active to 'deactive' form is enhanced by acute hypoxia in endothelial cells and brain tissue, and we suggest that it can trigger ROS production through its Na(+)/H(+) antiporter activity. These results highlight the role of complex I as a key actor in redox signalling in acute hypoxia.

Published
2017

14. Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia

Author

Hernansanz-Agustín, Pablo, primary, Ramos, Elena, additional, Navarro, Elisa, additional, Parada, Esther, additional, Sánchez-López, Nuria, additional, Peláez-Aguado, Laura, additional, Cabrera-García, J. Daniel, additional, Tello, Daniel, additional, Buendia, Izaskun, additional, Marina, Anabel, additional, Egea, Javier, additional, López, Manuela G., additional, Bogdanova, Anna, additional, and Martínez-Ruiz, Antonio, additional

Published
2017
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15. Regulation of SCF TIR1/AFBs E3 ligase assembly by S-nitrosylation of Arabidopsis SKP1-like1 impacts on auxin signaling.

Author

Iglesias MJ, Terrile MC, Correa-Aragunde N, Colman SL, Izquierdo-Álvarez A, Fiol DF, París R, Sánchez-López N, Marina A, Calderón Villalobos LIA, Estelle M, Lamattina L, Martínez-Ruiz A, and Casalongué CA

Subjects
Models, Molecular, Nitroso Compounds metabolism, Protein Interaction Maps, Ubiquitin-Protein Ligases metabolism, Arabidopsis metabolism, Arabidopsis Proteins metabolism, F-Box Proteins metabolism, Indoleacetic Acids metabolism, Nitric Oxide metabolism, Receptors, Cell Surface metabolism, SKP Cullin F-Box Protein Ligases metabolism, Signal Transduction
Abstract

The F-box proteins (FBPs) TIR1/AFBs are the substrate recognition subunits of SKP1-cullin-F-box (SCF) ubiquitin ligase complexes and together with Aux/IAAs form the auxin co-receptor. Although tremendous knowledge on auxin perception and signaling has been gained in the last years, SCF TIR1/AFBs complex assembly and stabilization are emerging as new layers of regulation. Here, we investigated how nitric oxide (NO), through S-nitrosylation of ASK1 is involved in SCF TIR1/AFBs assembly. We demonstrate that ASK1 is S-nitrosylated and S-glutathionylated in cysteine (Cys) 37 and Cys118 residues in vitro. Both, in vitro and in vivo protein-protein interaction assays show that NO enhances ASK1 binding to CUL1 and TIR1/AFB2, required for SCF TIR1/AFB2 assembly. In addition, we demonstrate that Cys37 and Cys118 are essential residues for proper activation of auxin signaling pathway in planta. Phylogenetic analysis revealed that Cys37 residue is only conserved in SKP proteins in Angiosperms, suggesting that S-nitrosylation on Cys37 could represent an evolutionary adaption for SKP1 function in flowering plants. Collectively, these findings indicate that multiple events of redox modifications might be part of a fine-tuning regulation of SCF TIR1/AFBs for proper auxin signal transduction., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2018
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