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2. Omentum preservation versus complete omentectomy in gastrectomy for gastric cancer (OMEGA trial): study protocol for a randomized controlled trial

Author

Keywani, K., Eshuis, W. J., Borgstein, A. B. J., van Det, M. J., van Duijvendijk, P., van Etten, B., Grimminger, P. P., Heisterkamp, J., Lagarde, S. M., Luyer, M. D. P., Markar, S. R., Meijer, S. L., Pierie, J. P. E. N., Roviello, F., Ruurda, J. P., van Sandick, J. W., Sosef, M., Witteman, B. P. L., de Steur, W. O., Lissenberg-Witte, B. I., van Berge Henegouwen, M. I., and Gisbertz, S. S.

Published
2024
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5. A systematic review on the effectiveness of robot-assisted minimally invasive gastrectomy

Author

MS CGO, Cancer, Fysica Radiotherapie Research, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Triemstra, L., den Boer, R. B., Rovers, M. M., Hazenberg, C. E.V.B., van Hillegersberg, R., Grutters, J. P.C., Ruurda, J. P., MS CGO, Cancer, Fysica Radiotherapie Research, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Triemstra, L., den Boer, R. B., Rovers, M. M., Hazenberg, C. E.V.B., van Hillegersberg, R., Grutters, J. P.C., and Ruurda, J. P.

Published
2024

6. Omentum preservation versus complete omentectomy in gastrectomy for gastric cancer (OMEGA trial): study protocol for a randomized controlled trial

Author

MS CGO, Cancer, Keywani, K, Eshuis, W J, Borgstein, A B J, van Det, M J, van Duijvendijk, P, van Etten, B, Grimminger, P P, Heisterkamp, J, Lagarde, S M, Luyer, M D P, Markar, S R, Meijer, S L, Pierie, J P E N, Roviello, F, Ruurda, J P, van Sandick, J W, Sosef, M, Witteman, B P L, de Steur, W O, Lissenberg-Witte, B I, van Berge Henegouwen, M I, Gisbertz, S S, MS CGO, Cancer, Keywani, K, Eshuis, W J, Borgstein, A B J, van Det, M J, van Duijvendijk, P, van Etten, B, Grimminger, P P, Heisterkamp, J, Lagarde, S M, Luyer, M D P, Markar, S R, Meijer, S L, Pierie, J P E N, Roviello, F, Ruurda, J P, van Sandick, J W, Sosef, M, Witteman, B P L, de Steur, W O, Lissenberg-Witte, B I, van Berge Henegouwen, M I, and Gisbertz, S S

Published
2024

7. Omentum preservation versus complete omentectomy in gastrectomy for gastric cancer (OMEGA trial):study protocol for a randomized controlled trial

Author

Keywani, K., Eshuis, W. J., Borgstein, A. B.J., van Det, M. J., van Duijvendijk, P., van Etten, B., Grimminger, P. P., Heisterkamp, J., Lagarde, S. M., Luyer, M. D.P., Markar, S. R., Meijer, S. L., Pierie, J. P.E.N., Roviello, F., Ruurda, J. P., van Sandick, J. W., Sosef, M., Witteman, B. P.L., de Steur, W. O., Lissenberg-Witte, B. I., van Berge Henegouwen, M. I., Gisbertz, S. S., Keywani, K., Eshuis, W. J., Borgstein, A. B.J., van Det, M. J., van Duijvendijk, P., van Etten, B., Grimminger, P. P., Heisterkamp, J., Lagarde, S. M., Luyer, M. D.P., Markar, S. R., Meijer, S. L., Pierie, J. P.E.N., Roviello, F., Ruurda, J. P., van Sandick, J. W., Sosef, M., Witteman, B. P.L., de Steur, W. O., Lissenberg-Witte, B. I., van Berge Henegouwen, M. I., and Gisbertz, S. S.

Abstract

Background: Potentially curative therapy for locally advanced gastric cancer consists of gastrectomy, usually in combination with perioperative chemotherapy. An oncological resection includes a radical (R0) gastrectomy and modified D2 lymphadenectomy; generally, a total omentectomy is also performed, to ensure the removal of possible microscopic disease. However, the omentum functions as a regulator of regional immune responses to prevent infections and prevents adhesions which could lead to bowel obstructions. Evidence supporting a survival benefit of routine complete omentectomy during gastrectomy is lacking. Methods: OMEGA is a randomized controlled, open, parallel, non-inferiority, multicenter trial. Eligible patients are operable (ASA < 4) and have resectable (≦ cT4aN3bM0) primary gastric cancer. Patients will be 1:1 randomized between (sub)total gastrectomy with omentum preservation distal of the gastroepiploic vessels versus complete omentectomy. For a power of 80%, the target sample size is 654 patients. The primary objective is to investigate whether omentum preservation in gastrectomy for cancer is non-inferior to complete omentectomy in terms of 3-year overall survival. Secondary endpoints include intra- and postoperative outcomes, such as blood loss, operative time, hospital stay, readmission rate, quality of life, disease-free survival, and cost-effectiveness. Discussion: The OMEGA trial investigates if omentum preservation during gastrectomy for gastric cancer is non-inferior to complete omentectomy in terms of 3-year overall survival, with non-inferiority being determined based on results from both the intention-to-treat and the per-protocol analyses. The OMEGA trial will elucidate whether routine complete omentectomy could be omitted, potentially reducing overtreatment. Trial registration: ClinicalTrials.gov NCT05180864. Registered on 6th January 2022.

Published
2024

8. Adjuvant Therapy for Patients with a Tumor-Positive Resection Margin After Neoadjuvant Chemoradiotherapy and Esophagectomy

Author

van der Zijden, C. J., van der Sluis, P. C., Mostert, B., Nuyttens, J. J.M.E., Spaander, V. M.C.W., Valkema, R., Ruurda, J. P., Wijnhoven, B. P.L., Lagarde, S. M., van der Zijden, C. J., van der Sluis, P. C., Mostert, B., Nuyttens, J. J.M.E., Spaander, V. M.C.W., Valkema, R., Ruurda, J. P., Wijnhoven, B. P.L., and Lagarde, S. M.

Abstract

Background: Approximately 4–9% of patients have a tumor-positive resection margin after neoadjuvant chemoradiotherapy (nCRT) and esophagectomy. Although it is associated with decreased survival, Western guidelines do not recommend adjuvant treatment. Objective: The aim of this study was to assess the proportion of patients who received adjuvant therapy, and to evaluate overall survival (OS) after esophagectomy in patients with a tumor-positive resection margin. Methods: Patients diagnosed with resectable (cT2-4a/cTxN0-3/NxM0) esophageal cancer between 2015 and 2022, and treated with nCRT followed by irradical esophagectomy, were selected from the Netherlands Cancer Registry. The primary outcome was the proportion of patients with a tumor-positive resection margin who started adjuvant treatment ≤16 weeks after esophagectomy, including chemotherapy/radiotherapy, immunotherapy, or targeted therapy. OS was calculated from the date of surgery until the date of death or last day of follow-up. Results: Overall, 376 patients were included in our study, of whom 357 were treated with nCRT. Of these 357 patients, 98.3% had a microscopically irradical resection and 1.7% had a macroscopically irradical resection. Approximately 72.3% of tumors showed a partial response (Mandard 2–3) and 11.8% showed little/no pathological response (Mandard 4–5) to nCRT. One of 357 patients underwent adjuvant chemoradiotherapy and 39 patients (61%) underwent adjuvant immunotherapy (nivolumab). The median and 5-year OS rate of all patients was 16.4 months (95% confidence interval 13.1–19.8) and 21%, respectively. Conclusion: Real-world population-level data showed that no patients with a tumor-positive resection margin underwent adjuvant therapy following nCRT and esophagectomy prior to 2021. Interestingly, 61% of patients were treated with adjuvant nivolumab in 2021–2022. OS after irradical esophag

Published
2024

10. Surgical treatment of esophago-tracheobronchial fistulas after esophagectomy

Author

Cancer, MS CGO, Heelkunde Opleiding, CTC, Circulatory Health, MS Oogheelkunde, Other research (not in main researchprogram), Medische staf Anesthesiologie, Cardiologie, de Groot, E M, Kingma, B F, Goense, L, van der Kaaij, N P, Meijer, R C A, Ramjankhan, F Z, Schellekens, P A A, Braithwaite, S A, Marsman, M, van der Heijden, J J, Ruurda, J P, van Hillegersberg, R, Cancer, MS CGO, Heelkunde Opleiding, CTC, Circulatory Health, MS Oogheelkunde, Other research (not in main researchprogram), Medische staf Anesthesiologie, Cardiologie, de Groot, E M, Kingma, B F, Goense, L, van der Kaaij, N P, Meijer, R C A, Ramjankhan, F Z, Schellekens, P A A, Braithwaite, S A, Marsman, M, van der Heijden, J J, Ruurda, J P, and van Hillegersberg, R

Published
2024

11. Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus minimally invasive esophagectomy for resectable esophageal adenocarcinoma, a randomized controlled trial (ROBOT-2 trial)

Author

Tagkalos, E., van der Sluis, P. C., Berlth, F., Poplawski, A., Hadzijusufovic, E., Lang, H., van Berge Henegouwen, M. I., Gisbertz, S. S., Müller-Stich, B. P., Ruurda, J. P., Schiesser, M., Schneider, P. M., van Hillegersberg, R., and Grimminger, P. P.

Published
2021
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12. Paravertebral catheter versus EPidural analgesia in Minimally invasive Esophageal resectioN: a randomized controlled multicenter trial (PEPMEN trial)

Author

Kingma, B. F., Eshuis, W. J., de Groot, E. M., Feenstra, M. L., Ruurda, J. P., Gisbertz, S. S., ten Hoope, W., Marsman, M., Hermanides, J., Hollmann, M. W., Kalkman, C. J., Luyer, M. D. P., Nieuwenhuijzen, G. A. P., Scholten, H. J., Buise, M., van Det, M. J., Kouwenhoven, E. A., van der Meer, F., Frederix, G. W. J., Cheong, E., al Naimi, K., van Berge Henegouwen, M. I., and van Hillegersberg, R.

Published
2020
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13. Laparoscopic ischemic conditioning of the stomach prior to esophagectomy induces gastric neo-angiogenesis

Author

Cancer, MS CGO, MCS-team, Schiffmann, L. M., de Groot, E., Albert, M. C., Quaas, A., Pinto dos Santos, D., Babic, B., Fuchs, H. F., Walczak, H., Chon, S. H., Ruurda, J. P., Kashkar, H., Bruns, C. J., Schröder, W., van Hillegersberg, R., Cancer, MS CGO, MCS-team, Schiffmann, L. M., de Groot, E., Albert, M. C., Quaas, A., Pinto dos Santos, D., Babic, B., Fuchs, H. F., Walczak, H., Chon, S. H., Ruurda, J. P., Kashkar, H., Bruns, C. J., Schröder, W., and van Hillegersberg, R.

Published
2023

14. Postoperative and Pathological Outcomes of CROSS and FLOT as Neoadjuvant Therapy for Esophageal and Junctional Adenocarcinoma: An International Cohort Study From the Oesophagogastric Anastomosis Audit (OGAA)

Author

MS CGO, Cancer, Steering Committee, Committee, Alderson, D., Bundred, J., Rpt, Evans, Gossage, J., Griffiths, E. A., Jefferies, B., Kamarajah, S. K., McKay, S., Mohamed, Nepogodiev, D., Siaw- Acheampong, K., Singh, P., Van Hillegersberg, R., Vohra, R., Wanigasooriya, K., Whitehouse, T., National Leads, Leads, Gjata, A., Moreno, J. I., Takeda, F. R., Kidane, B., Guevara Castro, R., Harustiak, T., Bekele, A., Kechagias, A., Gockel, Kennedy, A., Da Roit, A., Bagajevas, A., Azagra, J. S., Mahendran, H. A., Mejía-Fernández, L., Wijnhoven, B. P.L., El Kafsi, J., Sayyed, R. H., Sousa, M., Sampaio, A. S., Negoi, Blanco, R., Wallner, B., Schneider, P. M., Hsu, P. K., Isik, A., Leads, Site, Gananadha, S., Wills, Devadas, M., Duong, C., Talbot, M., Hii, M. W., Jacobs, R., Andreollo, N. A., Johnston, B., Darling, G., Isaza-Restrepo, A., Rosero, G., Arias-Amézquita, F., Raptis, D., Gaedcke, J., Reim, D., Izbicki, J., Egberts, J. H., Dikinis, S., Kjaer, D. W., Larsen, M. H., Achiam, M. P., Saarnio, J., Theodorou, D., Liakakos, T., Korkolis, D. P., Robb, W. B., Collins, C., Murphy, T., Reynolds, J., Tonini, Migliore, M., Bonavina, L., Valmasoni, M., Bardini, R., Weindelmayer, J., Terashima, M., White, R. E., Alghunaim, E., Elhadi, M., Leon-Takahashi, A. M., Medina-Franco, H., Lau, P. C., Okonta, K. E., Heisterkamp, J., Rosman, C., Beban, G., Babor, R., Gordon, A., Rossaak, J. I., Pal, K. M.I., Qureshi, A. U., Naqi, S. A., Syed, A. A., Barbosa, J., Vicente, C. S., Leite, J., Freire, J., Casaca, R., Costa, R. C.T., Scurtu, R. R., Mogoanta, S. S., Bolca, C., Constantinoiu, S., Sekhniaidze, D., Bjelović, M., So, J. B.Y., Gačevski, G., Loureiro, C., Pera, M., Bianchi, A., Moreno Gijón, M., Martín Fernández, J., Trugeda Carrera, M. S., Vallve-Bernal, M., Cítores Pascual, M. A., Elmahi, S., Halldestam, Hedberg, J., Mönig, S., Gutknecht, S., Tez, M., Guner, A., Tirnaksiz, M. B., Colak, E., Sevinç, B., Hindmarsh, A., Khan, Khoo, D., Byrom, R., Gokhale, J., Wilkerson, P., Jain, P., Chan, D., Robertson, K., Iftikhar, S., Skipworth, R., Forshaw, M., Higgs, S., Nijjar, R., Viswanath, Y. K.S., Turner, P., Dexter, S., Boddy, A., Allum, W. H., Oglesby, S., Cheong, E., Beardsmore, D., Maynard, N., Berrisford, R., Mercer, S., Puig, S., Melhado, R., Kelty, C., Underwood, T., Dawas, K., Lewis, W., Al-Bahrani, A., Bryce, G., Thomas, M., Arndt, A. T., Palazzo, F., Meguid, R. A., Collaborators, Fergusson, J., Beenen, E., Mosse, C., Salim, J., Cheah, S., Wright, T., Cerdeira, M. P., McQuillan, P., Richardson, M., Liem, H., Spillane, J., Yacob, M., Albadawi, F., Thorpe, T., Dingle, A., Cabalag, C., Loi, K., Fisher, O. M., Ward, S., Read, M., Johnson, M., Bassari, R., Bui, H., Cecconello, Raa, Sallum, Da Rocha, J. R.M., Lopes, L. R., Tercioti, V., Jds, Coelho, Ferrer, J. A.P., Buduhan, G., Tan, L., Srinathan, S., Shea, P., Yeung, J., Allison, F., Carroll, P., Vargas-Barato, F., Gonzalez, F., Ortega, J., Nino-Torres, L., Beltrán-García, T. C., Castilla, L., Pineda, M., Bastidas, A., Gómez-Mayorga, J., Cortés, N., Cetares, C., Caceres, S., Duarte, S., Pazdro, A., Snajdauf, M., Faltova, H., Sevcikova, M., Mortensen, P. B., Katballe, N., Ingemann, T., Kruhlikava, Morten B., Ainswort, A. P., Stilling, N. M., Eckardt, J., Holm, J., Thorsteinsson, M., Siemsen, M., Brandt, B., Nega, B., Teferra, E., Tizazu, A., Kauppila, J. H., Koivukangas, V., Meriläinen, S., Gruetzmann, R., Krautz, C., Weber, G., Golcher, H., Emons, G., Azizian, A., Ebeling, M., Niebisch, S., Kreuser, N., Albanese, G., Hesse, J., Volovnik, L., Boecher, U., Reeh, M., Triantafyllou, S., Schizas, D., Michalinos, A., Balli, E., Mpoura, M., Charalabopoulos, A., Manatakis, D. K., Balalis, D., Bolger, J., Baban, C., Mastrosimone, A., McAnena, O., Quinn, A., Ó Súilleabháin, C. B., Hennessy, M. M., Ivanovski, Khizer, H., Ravi, N., Donlon, N., Cervellera, M., Vaccari, S., Bianchini, S., Sartarelli, L., Asti, E., Bernardi, D., Merigliano, S., Provenzano, L., Scarpa, M., Saadeh, L., Salmaso, B., De Manzoni, G., Giacopuzzi, S., La Mendola, R., De Pasqual, C. A., Tsubosa, Y., Niihara, M., Irino, T., Makuuchi, R., Ishii, K., Mwachiro, M., Fekadu, A., Odera, A., Mwachiro, E., Alshehab, D., Ahmed, H. A., Shebani, A. O., Elhadi, A., Elnagar, F. A., Elnagar, H. F., Makkai-Popa, S. T., Wong, L. F., Tan, Y. R., Thannimalai, S., Ho, C. A., Pang, W. S., Tan, J. H., Hnl, Basave, Cortés-González, R., Lagarde, S. M., Van Lanschot, J. J.B., Cords, C., Jansen, W. A., Martijnse, I., Matthijsen, R., Bouwense, S., Klarenbeek, B., Verstegen, M., Van Workum, F., Ruurda, J. P., Van Der Sluis, P. C., De Maat, M., Evenett, N., Johnston, P., Patel, R., MacCormick, A., Young, M., Smith, B., Ekwunife, C., Memon, A. H., Shaikh, K., Wajid, A., Khalil, N., Haris, M., Mirza, Z. U., Sba, Qudus, Sarwar, M. Z., Shehzadi, A., Raza, A., Jhanzaib, M. H., Farmanali, J., Zakir, Z., Shakeel, O., Nasir, Khattak, S., Baig, M., Noor, M. A., Ahmed, H. H., Naeem, A., Pinho, A. C., Da Silva, R., Bernardes, A., Campos, J. C., Matos, H., Braga, T., Monteiro, C., Ramos, P., Cabral, F., Gomes, M. P., Martins, P. C., Correia, A. M., Videira, J. F., Ciuce, C., Drasovean, R., Apostu, R., Paitici, S., Racu, A. E., Obleaga, C. V., Beuran, M., Stoica, B., Negoita, Ciubotaru C., Cordos, Birla, R. D., Predescu, D., Hoara, P. A., Tomsa, R., Shneider, Agasiev, M., Ganjara, Gunjić, D., Veselinović, M., Babič, T., Chin, T. S., Shabbir, A., Kim, G., Crnjac, A., Samo, H., Díez Del Val, Del Val, Leturio, S., Ramón, J. M., Dal Cero, M., Rifá, S., Rico, M., Pagan Pomar, A., Martinez Corcoles, J. A., Rodicio Miravalles, J. L., Pais, S. A., Turienzo, S. A., Alvarez, L. S., Campos, P. V., Rendo, A. G., García, S. S., Epg, Santos, Martínez, E. T., Fernández Díaz, M. J., Magadán Álvarez, C., Martín, Concepción, Díaz López, C., Rosat Rodrigo, A., Pérez Sánchez, L. E., Bailón Cuadrado, M., Tinoco Carrasco, C., Choolani Bhojwani, E., Sánchez, D. P., Ahmed, M. E., Dzhendov, T., Lindberg, F., Rutegård, M., Sundbom, M., Mickael, C., Colucci, N., Schnider, A., Er, S., Kurnaz, E., Turkyilmaz, S., Turkyilmaz, A., Yildirim, R., Baki, B. E., Akkapulu, N., Karahan, O., Damburaci, N., Hardwick, R., Safranek, P., Sujendran, Bennett, J., Afzal, Z., Shrotri, M., Chan, B., Exarchou, K., Gilbert, T., Amalesh, T., Mukherjee, D., Mukherjee, S., Wiggins, T. H., Kennedy, R., McCain, S., Harris, A., Dobson, G., Davies, N., Wilson, I., Mayo, D., Bennett, D., Young, R., Manby, P., Blencowe, N., Schiller, M., Byrne, B., Mitton, D., Wong, V., Elshaer, A., Cowen, M., Menon, Tan, L. C., McLaughlin, E., Koshy, R., Sharp, C., Brewer, H., Das, N., Cox, M., Al Khyatt, W., Worku, D., Iqbal, R., Walls, L., McGregor, R., Fullarton, G., MacDonald, A., MacKay, C., Craig, C., Dwerryhouse, S., Hornby, S., Jaunoo, S., Wadley, M., Baker, C., Saad, M., Kelly, M., Davies, A., Di Maggio, F., Mistry, P., Singhal, R., Tucker, O., Kapoulas, S., Powell-Brett, S., Davis, P., Bromley, G., Watson, L., Verma, R., Ward, J., Shetty, V., Ball, C., Pursnani, K., Sarela, A., Sue Ling, H., Mehta, S., Hayden, J., To, N., Palser, T., Hunter, D., Supramaniam, K., Butt, Z., Ahmed, A., Kumar, S., Chaudry, A., Moussa, O., Kordzadeh, A., Wilson, M. Lorenzi B., Patil, P., Noaman, Willem, J., Bouras, G., Evans, R., Singh, M., Warrilow, H., Ahmad, A., Tewari, N., Yanni, F., Couch, J., Theophilidou, E., Reilly, J. J., Van Boxel, Gijs, Akbari, K., Zanotti, D., Sgromo, B., Sanders, G., Wheatley, T., Ariyarathenam, A., Reece-Smith, A., Humphreys, L., Choh, C., Carter, N., Knight, B., Pucher, P., Athanasiou, A., Tan, B., Abdulrahman, M., Vickers, J., Akhtar, K., Chaparala, R., Brown, R., Alasmar, M. M.A., Ackroyd, R., Patel, K., Tamhankar, A., Wyman, A., Walker, R., Grace, B., Abbassi, N., Slim, N., Ioannidi, L., Blackshaw, G., Havard, T., Escofet, X., Powell, A., Owera, A., Rashid, F., Jambulingam, P., Padickakudi, J., Ben-Younes, H., McCormack, K., Makey, I. A., Karush, M. K., Seder, C. W., Liptay, M. J., Chmielewski, G., Rosato, E. L., Berger, A. C., Zheng, R., Okolo, E., Singh, A., Scott, C. D., Weyant, M. J., Mitchell, J. D., MS CGO, Cancer, Steering Committee, Committee, Alderson, D., Bundred, J., Rpt, Evans, Gossage, J., Griffiths, E. A., Jefferies, B., Kamarajah, S. K., McKay, S., Mohamed, Nepogodiev, D., Siaw- Acheampong, K., Singh, P., Van Hillegersberg, R., Vohra, R., Wanigasooriya, K., Whitehouse, T., National Leads, Leads, Gjata, A., Moreno, J. I., Takeda, F. R., Kidane, B., Guevara Castro, R., Harustiak, T., Bekele, A., Kechagias, A., Gockel, Kennedy, A., Da Roit, A., Bagajevas, A., Azagra, J. S., Mahendran, H. A., Mejía-Fernández, L., Wijnhoven, B. P.L., El Kafsi, J., Sayyed, R. H., Sousa, M., Sampaio, A. S., Negoi, Blanco, R., Wallner, B., Schneider, P. M., Hsu, P. K., Isik, A., Leads, Site, Gananadha, S., Wills, Devadas, M., Duong, C., Talbot, M., Hii, M. W., Jacobs, R., Andreollo, N. A., Johnston, B., Darling, G., Isaza-Restrepo, A., Rosero, G., Arias-Amézquita, F., Raptis, D., Gaedcke, J., Reim, D., Izbicki, J., Egberts, J. H., Dikinis, S., Kjaer, D. W., Larsen, M. H., Achiam, M. P., Saarnio, J., Theodorou, D., Liakakos, T., Korkolis, D. P., Robb, W. B., Collins, C., Murphy, T., Reynolds, J., Tonini, Migliore, M., Bonavina, L., Valmasoni, M., Bardini, R., Weindelmayer, J., Terashima, M., White, R. E., Alghunaim, E., Elhadi, M., Leon-Takahashi, A. M., Medina-Franco, H., Lau, P. C., Okonta, K. E., Heisterkamp, J., Rosman, C., Beban, G., Babor, R., Gordon, A., Rossaak, J. I., Pal, K. M.I., Qureshi, A. U., Naqi, S. A., Syed, A. A., Barbosa, J., Vicente, C. S., Leite, J., Freire, J., Casaca, R., Costa, R. C.T., Scurtu, R. R., Mogoanta, S. S., Bolca, C., Constantinoiu, S., Sekhniaidze, D., Bjelović, M., So, J. B.Y., Gačevski, G., Loureiro, C., Pera, M., Bianchi, A., Moreno Gijón, M., Martín Fernández, J., Trugeda Carrera, M. S., Vallve-Bernal, M., Cítores Pascual, M. A., Elmahi, S., Halldestam, Hedberg, J., Mönig, S., Gutknecht, S., Tez, M., Guner, A., Tirnaksiz, M. B., Colak, E., Sevinç, B., Hindmarsh, A., Khan, Khoo, D., Byrom, R., Gokhale, J., Wilkerson, P., Jain, P., Chan, D., Robertson, K., Iftikhar, S., Skipworth, R., Forshaw, M., Higgs, S., Nijjar, R., Viswanath, Y. K.S., Turner, P., Dexter, S., Boddy, A., Allum, W. H., Oglesby, S., Cheong, E., Beardsmore, D., Maynard, N., Berrisford, R., Mercer, S., Puig, S., Melhado, R., Kelty, C., Underwood, T., Dawas, K., Lewis, W., Al-Bahrani, A., Bryce, G., Thomas, M., Arndt, A. T., Palazzo, F., Meguid, R. A., Collaborators, Fergusson, J., Beenen, E., Mosse, C., Salim, J., Cheah, S., Wright, T., Cerdeira, M. P., McQuillan, P., Richardson, M., Liem, H., Spillane, J., Yacob, M., Albadawi, F., Thorpe, T., Dingle, A., Cabalag, C., Loi, K., Fisher, O. M., Ward, S., Read, M., Johnson, M., Bassari, R., Bui, H., Cecconello, Raa, Sallum, Da Rocha, J. R.M., Lopes, L. R., Tercioti, V., Jds, Coelho, Ferrer, J. A.P., Buduhan, G., Tan, L., Srinathan, S., Shea, P., Yeung, J., Allison, F., Carroll, P., Vargas-Barato, F., Gonzalez, F., Ortega, J., Nino-Torres, L., Beltrán-García, T. C., Castilla, L., Pineda, M., Bastidas, A., Gómez-Mayorga, J., Cortés, N., Cetares, C., Caceres, S., Duarte, S., Pazdro, A., Snajdauf, M., Faltova, H., Sevcikova, M., Mortensen, P. B., Katballe, N., Ingemann, T., Kruhlikava, Morten B., Ainswort, A. P., Stilling, N. M., Eckardt, J., Holm, J., Thorsteinsson, M., Siemsen, M., Brandt, B., Nega, B., Teferra, E., Tizazu, A., Kauppila, J. H., Koivukangas, V., Meriläinen, S., Gruetzmann, R., Krautz, C., Weber, G., Golcher, H., Emons, G., Azizian, A., Ebeling, M., Niebisch, S., Kreuser, N., Albanese, G., Hesse, J., Volovnik, L., Boecher, U., Reeh, M., Triantafyllou, S., Schizas, D., Michalinos, A., Balli, E., Mpoura, M., Charalabopoulos, A., Manatakis, D. K., Balalis, D., Bolger, J., Baban, C., Mastrosimone, A., McAnena, O., Quinn, A., Ó Súilleabháin, C. B., Hennessy, M. M., Ivanovski, Khizer, H., Ravi, N., Donlon, N., Cervellera, M., Vaccari, S., Bianchini, S., Sartarelli, L., Asti, E., Bernardi, D., Merigliano, S., Provenzano, L., Scarpa, M., Saadeh, L., Salmaso, B., De Manzoni, G., Giacopuzzi, S., La Mendola, R., De Pasqual, C. A., Tsubosa, Y., Niihara, M., Irino, T., Makuuchi, R., Ishii, K., Mwachiro, M., Fekadu, A., Odera, A., Mwachiro, E., Alshehab, D., Ahmed, H. A., Shebani, A. O., Elhadi, A., Elnagar, F. A., Elnagar, H. F., Makkai-Popa, S. T., Wong, L. F., Tan, Y. R., Thannimalai, S., Ho, C. A., Pang, W. S., Tan, J. H., Hnl, Basave, Cortés-González, R., Lagarde, S. M., Van Lanschot, J. J.B., Cords, C., Jansen, W. A., Martijnse, I., Matthijsen, R., Bouwense, S., Klarenbeek, B., Verstegen, M., Van Workum, F., Ruurda, J. P., Van Der Sluis, P. C., De Maat, M., Evenett, N., Johnston, P., Patel, R., MacCormick, A., Young, M., Smith, B., Ekwunife, C., Memon, A. H., Shaikh, K., Wajid, A., Khalil, N., Haris, M., Mirza, Z. U., Sba, Qudus, Sarwar, M. Z., Shehzadi, A., Raza, A., Jhanzaib, M. H., Farmanali, J., Zakir, Z., Shakeel, O., Nasir, Khattak, S., Baig, M., Noor, M. A., Ahmed, H. H., Naeem, A., Pinho, A. C., Da Silva, R., Bernardes, A., Campos, J. C., Matos, H., Braga, T., Monteiro, C., Ramos, P., Cabral, F., Gomes, M. P., Martins, P. C., Correia, A. M., Videira, J. F., Ciuce, C., Drasovean, R., Apostu, R., Paitici, S., Racu, A. E., Obleaga, C. V., Beuran, M., Stoica, B., Negoita, Ciubotaru C., Cordos, Birla, R. D., Predescu, D., Hoara, P. A., Tomsa, R., Shneider, Agasiev, M., Ganjara, Gunjić, D., Veselinović, M., Babič, T., Chin, T. S., Shabbir, A., Kim, G., Crnjac, A., Samo, H., Díez Del Val, Del Val, Leturio, S., Ramón, J. M., Dal Cero, M., Rifá, S., Rico, M., Pagan Pomar, A., Martinez Corcoles, J. A., Rodicio Miravalles, J. L., Pais, S. A., Turienzo, S. A., Alvarez, L. S., Campos, P. V., Rendo, A. G., García, S. S., Epg, Santos, Martínez, E. T., Fernández Díaz, M. J., Magadán Álvarez, C., Martín, Concepción, Díaz López, C., Rosat Rodrigo, A., Pérez Sánchez, L. E., Bailón Cuadrado, M., Tinoco Carrasco, C., Choolani Bhojwani, E., Sánchez, D. P., Ahmed, M. E., Dzhendov, T., Lindberg, F., Rutegård, M., Sundbom, M., Mickael, C., Colucci, N., Schnider, A., Er, S., Kurnaz, E., Turkyilmaz, S., Turkyilmaz, A., Yildirim, R., Baki, B. E., Akkapulu, N., Karahan, O., Damburaci, N., Hardwick, R., Safranek, P., Sujendran, Bennett, J., Afzal, Z., Shrotri, M., Chan, B., Exarchou, K., Gilbert, T., Amalesh, T., Mukherjee, D., Mukherjee, S., Wiggins, T. H., Kennedy, R., McCain, S., Harris, A., Dobson, G., Davies, N., Wilson, I., Mayo, D., Bennett, D., Young, R., Manby, P., Blencowe, N., Schiller, M., Byrne, B., Mitton, D., Wong, V., Elshaer, A., Cowen, M., Menon, Tan, L. C., McLaughlin, E., Koshy, R., Sharp, C., Brewer, H., Das, N., Cox, M., Al Khyatt, W., Worku, D., Iqbal, R., Walls, L., McGregor, R., Fullarton, G., MacDonald, A., MacKay, C., Craig, C., Dwerryhouse, S., Hornby, S., Jaunoo, S., Wadley, M., Baker, C., Saad, M., Kelly, M., Davies, A., Di Maggio, F., Mistry, P., Singhal, R., Tucker, O., Kapoulas, S., Powell-Brett, S., Davis, P., Bromley, G., Watson, L., Verma, R., Ward, J., Shetty, V., Ball, C., Pursnani, K., Sarela, A., Sue Ling, H., Mehta, S., Hayden, J., To, N., Palser, T., Hunter, D., Supramaniam, K., Butt, Z., Ahmed, A., Kumar, S., Chaudry, A., Moussa, O., Kordzadeh, A., Wilson, M. Lorenzi B., Patil, P., Noaman, Willem, J., Bouras, G., Evans, R., Singh, M., Warrilow, H., Ahmad, A., Tewari, N., Yanni, F., Couch, J., Theophilidou, E., Reilly, J. J., Van Boxel, Gijs, Akbari, K., Zanotti, D., Sgromo, B., Sanders, G., Wheatley, T., Ariyarathenam, A., Reece-Smith, A., Humphreys, L., Choh, C., Carter, N., Knight, B., Pucher, P., Athanasiou, A., Tan, B., Abdulrahman, M., Vickers, J., Akhtar, K., Chaparala, R., Brown, R., Alasmar, M. M.A., Ackroyd, R., Patel, K., Tamhankar, A., Wyman, A., Walker, R., Grace, B., Abbassi, N., Slim, N., Ioannidi, L., Blackshaw, G., Havard, T., Escofet, X., Powell, A., Owera, A., Rashid, F., Jambulingam, P., Padickakudi, J., Ben-Younes, H., McCormack, K., Makey, I. A., Karush, M. K., Seder, C. W., Liptay, M. J., Chmielewski, G., Rosato, E. L., Berger, A. C., Zheng, R., Okolo, E., Singh, A., Scott, C. D., Weyant, M. J., and Mitchell, J. D.

Published
2023

16. Impact of body composition and physical strength changes during chemoradiotherapy on complications and survival after oesophagectomy

Author

Fysica Radiotherapie Research, Cancer, MS Radiologie, Circulatory Health, Afdeling Dietetiek, MS CGO, Researchgr. Systems Radiology, Infection & Immunity, Regenerative Medicine and Stem Cells, UMC Utrecht, den Boer, R. B., Defize, I. L., Veldhuis, W., Steenhagen, E., Kerst, A., van Hillegersberg, R., de Jong, P. A., Ruurda, J. P., Fysica Radiotherapie Research, Cancer, MS Radiologie, Circulatory Health, Afdeling Dietetiek, MS CGO, Researchgr. Systems Radiology, Infection & Immunity, Regenerative Medicine and Stem Cells, UMC Utrecht, den Boer, R. B., Defize, I. L., Veldhuis, W., Steenhagen, E., Kerst, A., van Hillegersberg, R., de Jong, P. A., and Ruurda, J. P.

Published
2023

17. Safety and Feasibility of Robot-Assisted Minimally Invasive Esophagectomy (RAMIE) with Three-Field Lymphadenectomy and Neoadjuvant Chemoradiotherapy in Patients with Resectable Esophageal Cancer and Cervical Lymph Node Metastasis

Author

MCS-team, MS CGO, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Other research (not in main researchprogram), MS Radiotherapie, Pathologie Pathologen staf, MS MDL 1, van der Horst, S., Weijs, T. J., Braunius, W. W., Mook, S., Mohammed, N. Haj, Brosens, L., van Rossum, P. S.N., Weusten, B. L.A.M., Ruurda, J. P., van Hillegersberg, R., MCS-team, MS CGO, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Other research (not in main researchprogram), MS Radiotherapie, Pathologie Pathologen staf, MS MDL 1, van der Horst, S., Weijs, T. J., Braunius, W. W., Mook, S., Mohammed, N. Haj, Brosens, L., van Rossum, P. S.N., Weusten, B. L.A.M., Ruurda, J. P., and van Hillegersberg, R.

Published
2023

18. The apron of the greater omentum of gastric cancer patients contains various lymphoid structures including lymph nodes

Author

Anatomie assistenten, MCS-team, Anatomie, Infection & Immunity, Pathologie Pathologen staf, Cancer, MS CGO, Schurink, B., Cleypool, C. G.J., Brosens, L. A.A., Ruurda, J. P., Mackaaij, Claire, Roeling, T. A.P., van Hillegersberg, R., Bleys, R. L.A.W., Anatomie assistenten, MCS-team, Anatomie, Infection & Immunity, Pathologie Pathologen staf, Cancer, MS CGO, Schurink, B., Cleypool, C. G.J., Brosens, L. A.A., Ruurda, J. P., Mackaaij, Claire, Roeling, T. A.P., van Hillegersberg, R., and Bleys, R. L.A.W.

Published
2023

19. ASO Visual Abstract: Safety and Feasibility of Robot-Assisted Minimally Invasive Esophagectomy (RAMIE) with Three-Field Lymphadenectomy and Neoadjuvant Chemoradiotherapy in Patients with Resectable Esophageal Cancer and Cervical Lymph Node Metastasis

Author

CTC, MS CGO, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Other research (not in main researchprogram), MS Radiotherapie, MS Medische Oncologie, Pathologie Pathologen staf, MS MDL 1, van der Horst, S., Weijs, T. J., Braunius, W. W., Mook, S., Mohammed, N. Haj, Brosens, L., van Rossum, P. S.N., Weusten, B. L.A.M., Ruurda, J. P., van Hillegersberg, R., CTC, MS CGO, Cancer, MS Hoofd-Hals Chirurgische Oncologie, Other research (not in main researchprogram), MS Radiotherapie, MS Medische Oncologie, Pathologie Pathologen staf, MS MDL 1, van der Horst, S., Weijs, T. J., Braunius, W. W., Mook, S., Mohammed, N. Haj, Brosens, L., van Rossum, P. S.N., Weusten, B. L.A.M., Ruurda, J. P., and van Hillegersberg, R.

Published
2023

20. Deep learning-based recognition of key anatomical structures during robot-assisted minimally invasive esophagectomy

Author

Fysica Radiotherapie Research, MS CGO, Cancer, den Boer, R B, Jaspers, T J M, de Jongh, C, Pluim, J P W, van der Sommen, F, Boers, T, van Hillegersberg, R, Van Eijnatten, M A J M, Ruurda, J P, Fysica Radiotherapie Research, MS CGO, Cancer, den Boer, R B, Jaspers, T J M, de Jongh, C, Pluim, J P W, van der Sommen, F, Boers, T, van Hillegersberg, R, Van Eijnatten, M A J M, and Ruurda, J P

Published
2023

21. The surgical anatomy of a (robot-assisted) minimally invasive transcervical esophagectomy

Author

Cancer, MS CGO, Anatomie, Infection & Immunity, Filz von Reiterdank, I C L J, Defize, I L, de Groot, E M, Wedel, T, Grimminger, P P, Egberts, J H, Stein, H, Ruurda, J P, van Hillegersberg, R, Bleys, R L A W, Cancer, MS CGO, Anatomie, Infection & Immunity, Filz von Reiterdank, I C L J, Defize, I L, de Groot, E M, Wedel, T, Grimminger, P P, Egberts, J H, Stein, H, Ruurda, J P, van Hillegersberg, R, and Bleys, R L A W

Published
2023

23. Indocyanine green fluorescence in robot-assisted minimally invasive esophagectomy with intrathoracic anastomosis: a prospective study

Author

Cancer, MS CGO, Arts-assistenten Radiotherapie, de Groot, E M, Kuiper, G M, van der Veen, A, Fourie, L, Goense, L, van der Horst, S, van den Berg, J W, van Hillegersberg, R, Ruurda, J P, Cancer, MS CGO, Arts-assistenten Radiotherapie, de Groot, E M, Kuiper, G M, van der Veen, A, Fourie, L, Goense, L, van der Horst, S, van den Berg, J W, van Hillegersberg, R, and Ruurda, J P

Published
2023

25. Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study)

Author

Brenkman, H. J. F., Gertsen, E. C., Vegt, E., van Hillegersberg, R., van Berge Henegouwen, M. I., Gisbertz, S. S., Luyer, M. D. P., Nieuwenhuijzen, G. A. P., van Lanschot, J. J. B., Lagarde, S. M., de Steur, W. O., Hartgrink, H. H., Stoot, J. H. M. B., Hulsewe, K. W. E., Spillenaar Bilgen, E. J., van Det, M. J., Kouwenhoven, E. A., van der Peet, D. L., Daams, F., van Sandick, J. W., van Grieken, N. C. T., Heisterkamp, J., van Etten, B., Haveman, J. W., Pierie, J. P., Jonker, F., Thijssen, A. Y., Belt, E. J. T., van Duijvendijk, P., Wassenaar, E., van Laarhoven, H. W. M., Wessels, F. J., Haj Mohammad, N., van Stel, H. F., Frederix, G. W. J., Siersema, P. D., Ruurda, J. P., and on behalf of the PLASTIC Study Group

Published
2018
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27. The ISCON-trial protocol: laparoscopic ischemic conditioning prior to esophagectomy in patients with esophageal cancer and arterial calcifications

Author

van der Veen, A., Schiffmann, L. M., de Groot, E. M., Bartella, I, de Jong, P. A., Borggreve, A. S., Brosens, L. A. A., Dos Santos, D. Pinto, Fuchs, H., Ruurda, J. P., Bruns, C. J., van Hillegersberg, R., Schroeder, W., van der Veen, A., Schiffmann, L. M., de Groot, E. M., Bartella, I, de Jong, P. A., Borggreve, A. S., Brosens, L. A. A., Dos Santos, D. Pinto, Fuchs, H., Ruurda, J. P., Bruns, C. J., van Hillegersberg, R., and Schroeder, W.

Abstract

Background: Anastomotic leakage is the most important surgical complication following esophagectomy. A major cause of leakage is ischemia of the gastric tube that is used for reconstruction of the gastrointestinal tract. Generalized cardiovascular disease, expressed by calcifications of the aorta and celiac axis stenosis on a pre-operative CT scan, is associated with an increased risk of anastomotic leakage. Laparoscopic ischemic conditioning (ISCON) aims to redistribute blood flow and increase perfusion at the anastomotic site by occluding the left gastric, left gastroepiploic and short gastric arteries prior to esophagectomy. This study aims to assess the safety and feasibility of laparoscopic ISCON in selected patients with esophageal cancer and concomitant arterial calcifications. Methods: In this prospective single-arm safety and feasibility trial based upon the IDEAL recommendations for surgical innovation, a total of 20 patients will be included recruited in 2 European high-volume centers for esophageal cancer surgery. Patients with resectable esophageal carcinoma (cT1-4a, N0-3, M0) with major calcifications of the thoracic aorta accordingly to the Uniform Calcification Score (UCS) or a stenosis of the celiac axis accordingly to the modified North American Symptomatic Carotid Endarterectomy Trial (NASCET) score on preoperative CT scan, who are planned to undergo esophagectomy are eligible for inclusion. The primary outcome variables are complications grade 2 and higher (Clavien-Dindo classification) occurring during or after laparoscopic ISCON and before esophagectomy. Secondary outcomes include intra- and postoperative complications of esophagectomy and the induction of angiogenesis by biomarkers of microcirculation and redistribution of blood flow by measurement of indocyanine green (ICG) fluorescence angiography. Discussion: We hypothesize that in selected patients with impaired vascularization of the gastric tube, laparoscopic ISCON is feasible and can be

Published
2022

29. Outcomes of surgical treatment of non-metastatic gastric cancer in patients aged 70 and older: A systematic review and meta-analysis

Author

Heelkunde Opleiding, MS CGO, Cancer, Argillander, T E, Festen, S, van der Zaag-Loonen, H J, de Graeff, P, van der Zaag, E S, van Leeuwen, B L, Nagengast, W B, Verhage, R J J, Ruurda, J P, van Munster, B C, van Duijvendijk, P, Heelkunde Opleiding, MS CGO, Cancer, Argillander, T E, Festen, S, van der Zaag-Loonen, H J, de Graeff, P, van der Zaag, E S, van Leeuwen, B L, Nagengast, W B, Verhage, R J J, Ruurda, J P, van Munster, B C, and van Duijvendijk, P

Published
2022

31. The ISCON-trial protocol: laparoscopic ischemic conditioning prior to esophagectomy in patients with esophageal cancer and arterial calcifications

Author

Arts-assistenten Radiotherapie, Cancer, MS CGO, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, Pathologie Pathologen staf, Veen, A van der, Schiffmann, L M, de Groot, E M, Bartella, I, de Jong, P A, Borggreve, A S, Brosens, L A A, Santos, D Pinto Dos, Fuchs, H, Ruurda, J P, Bruns, C J, van Hillegersberg, R, Schröder, W, Arts-assistenten Radiotherapie, Cancer, MS CGO, Researchgr. Systems Radiology, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, Pathologie Pathologen staf, Veen, A van der, Schiffmann, L M, de Groot, E M, Bartella, I, de Jong, P A, Borggreve, A S, Brosens, L A A, Santos, D Pinto Dos, Fuchs, H, Ruurda, J P, Bruns, C J, van Hillegersberg, R, and Schröder, W

Published
2022

32. Impact of nationwide centralization of oesophageal, gastric, and pancreatic surgery on travel distance and experienced burden in the Netherlands

Author

Arts Assistenten CTC, MS CGO, Cancer, MS HOD, Luijten, J. C.H.B.M., Nieuwenhuijzen, G. A.P., Sosef, M. N., de Hingh, I. H.J.T., Rosman, C., Ruurda, J. P., van Duijvendijk, P., Heisterkamp, J., de Steur, W. O., van Laarhoven, H. W.M., Besselink, M. G., Groot Koerkamp, B., van Santvoort, H. C., Lemmens, V. E.P., Vissers, P. A.J., Arts Assistenten CTC, MS CGO, Cancer, MS HOD, Luijten, J. C.H.B.M., Nieuwenhuijzen, G. A.P., Sosef, M. N., de Hingh, I. H.J.T., Rosman, C., Ruurda, J. P., van Duijvendijk, P., Heisterkamp, J., de Steur, W. O., van Laarhoven, H. W.M., Besselink, M. G., Groot Koerkamp, B., van Santvoort, H. C., Lemmens, V. E.P., and Vissers, P. A.J.

Published
2022

34. Postoperative outcomes in oesophagectomy with trainee involvement

Author

R P, T Evans, K Kamarajah, S, Bundred, J, Nepogodiev, D, Hodson, J, R van Hillegersberg, Gossage, J, Vohra, R, A Griffiths, E, Singh, P, Alderson, D, Jefferies, B, Mckay, S, Mohamed, I, K Siaw- Acheampong, Wanigasooriya, K, Whitehouse, T, Gjata, A, I Moreno, J, R Takeda, F, Kidane, B, R Guevara Castro, Harustiak, T, Bekele, A, Kechagias, A, Gockel, I, Kennedy, A, A Da Roit, Bagajevas, A, S Azagra, J, A Mahendran, H, Mej??a-Fern??ndez, L, B P, L Wijnhoven, J El Kafsi, H Sayyed, R, Sousa, M, S Sampaio, A, Negoi, I, Blanco, R, Wallner, B, M Schneider, P, K Hsu, P, Isik, A, Gananadha, S, Wills, V, Devadas, M, Duong, C, Talbot, M, W Hii, M, Jacobs, R, A Andreollo, N, Johnston, B, Darling, G, Isaza-Restrepo, A, Rosero, G, Arias-Am??zquita, F, Raptis, D, Gaedcke, J, Reim, D, Izbicki, J, H Egberts, J, Dikinis, S, W Kjaer, D, H Larsen, M, P Achiam, M, Saarnio, J, Theodorou, D, Liakakos, T, P Korkolis, D, B Robb, W, Collins, C, Murphy, T, Reynolds, J, Tonini, V, Migliore, M, Bonavina, L, Valmasoni, M, Bardini, R, Weindelmayer, J, Terashima, M, E White, R, Alghunaim, E, Elhadi, M, M Leon-Takahashi, A, Medina-Franco, H, C Lau, P, E Okonta, K, Heisterkamp, J, Rosman, C, Beban, G, Babor, R, Gordon, A, I Rossaak, J, K M, I Pal, U Qureshi, A, A Naqi, S, A Syed, A, Barbosa, J, S Vicente, C, Leite, J, Freire, J, Casaca, R, R C, T Costa, R Scurtu, R, S Mogoanta, S, Bolca, C, Constantinoiu, S, Sekhniaidze, D, Bjelovi??, M, J B, Y So, Ga??evski, G, Loureiro, C, Pera, M, Bianchi, A, M Moreno Gij??n, J Mart??n Fern??ndez, S Trugeda Carrera, M, Vallve-Bernal, M, A C??tores Pascual, M, Elmahi, S, Hedberg, J, M??nig, S, Gutknecht, S, Tez, M, Guner, A, B Tirnaksiz, T, Colak, E, Sevin??, B, Hindmarsh, A, Khan, I, Khoo, D, Byrom, R, Gokhale, J, Wilkerson, P, Jain, P, Chan, D, Robertson, K, Iftikhar, S, Skipworth, R, Forshaw, M, Higgs, S, Nijjar, R, Y K, S Viswanath, Turner, P, Dexter, S, Boddy, A, H Allum, W, Oglesby, S, Cheong, E, Beardsmore, D, Maynard, N, Berrisford, R, Mercer, S, Puig, S, Melhado, R, Kelty, C, Underwood, T, Dawas, K, Lewis, W, Al-Bahrani, A, Bryce, G, Thomas, M, T Arndt, A, Palazzo, F, A Meguid, R, Fergusson, J, Beenen, E, Mosse, C, Salim, J, Cheah, S, Wright, T, P Cerdeira, M, Mcquillan, P, Richardson, M, Liem, H, Spillane, J, Yacob, M, Albadawi, F, Thorpe, T, Dingle, A, Cabalag, C, Loi, K, M Fisher, O, Ward, S, Read, M, Johnson, M, Bassari, R, Bui, H, Cecconello, I, R A, A Sallum, J R, M da Rocha, R Lopes, L, Tercioti, V, J D, S Coelho, J A, P Ferrer, Buduhan, G, Tan, L, Srinathan, S, Shea, P, Yeung, J, Allison, F, Carroll, P, Vargas-Barato, F, Gonzalez, F, Ortega, J, Nino-Torres, L, C Beltr??n-Garc??a, T, Castilla, L, Pineda, M, Bastidas, A, G??mez-Mayorga, J, Cort??s, N, Cetares, C, Caceres, S, Duarte, S, Pazdro, A, Snajdauf, M, Faltova, H, Sevcikova, M, B Mortensen, P, Katballe, N, Ingemann, T, Morten, B, Kruhlikava, I, P Ainswort, A, M Stilling, N, Eckardt, J, Holm, J, Thorsteinsson, M, Siemsen, M, Brandt, B, Nega, B, Teferra, E, Tizazu, A, S Kauppila, J, Koivukangas, V, Meril??inen, S, Gruetzmann, R, Krautz, C, Weber, G, Golcher, H, Emons, G, Azizian, A, Ebeling, M, Niebisch, S, Kreuser, N, Albanese, G, Hesse, J, Volovnik, L, Boecher, U, Reeh, M, Triantafyllou, S, Schizas, D, Michalinos, A, Baili, E, Mpoura, M, Charalabopoulos, A, K Manatakis, D, Balalis, D, Bolger, J, Baban, C, Mastrosimone, A, Mcanena, O, Quinn, A, B ?? S??illeabh??in, C, M Hennessy, M, Ivanovski, I, Khizer, H, Ravi, N, Donlon, N, Cervellera, M, Vaccari, S, Bianchini, S, Sartarelli, L, Asti, E, Bernardi, D, Merigliano, S, Provenzano, L, Scarpa, M, Saadeh, L, Salmaso, B, DE MANZONI, Giovanni, Giacopuzzi, S, R La Mendola, A De Pasqual, C, Tsubosa, Y, Niihara, M, Irino, T, Makuuchi, R, Ishii, K, Mwachiro, M, Fekadu, A, Odera, A, Mwachiro, E, Alshehab, D, A Ahmed, H, O Shebani, A, Elhadi, A, A Elnagar, F, F Elnagar, H, T Makkai-Popa, S, F Wong, L, Yunrong, T, Thanninalai, S, C Aik, H, W Soon, P, J Huei, T, H N, L Basave, Cort??s-Gonz??lez, R, M Lagarde, S, J J, B van Lanschot, Cords, C, A Jansen, W, Martijnse, I, Matthijsen, R, Bouwense, S, Klarenbeek, B, Verstegen, M, F van Workum, P Ruurda, J, A van der Veen, W van den Berg, J, Evenett, N, Johnston, P, Patel, R, Maccormick, A, Young, M, Smith, B, Ekwunife, C, H Memon, A, Shaikh, K, Wajid, A, Khalil, N, Haris, M, U Mirza, Z, S B, A Qudus, Z Sarwar, M, Shehzadi, A, Raza, A, H Jhanzaib, M, Farmanali, J, Zakir, Z, Shakeel, O, Nasir, I, Khattak, S, Baig, M, A Noor, M, H Ahmed, H, Naeem, A, C Pinho, A, R da Silva, Matos, H, Braga, T, Monteiro, C, Ramos, P, Cabral, F, P Gomes, M, C Martins, P, M Correia, A, F Videira, J, Ciuce, C, Drasovean, R, Apostu, R, Paitici, S, E Racu, A, V Obleaga, C, Beuran, M, Stoica, B, Ciubotaru, C, Negoita, V, Cordos, I, D Birla, R, Predescu, D, A Hoara, P, Tomsa, R, Shneider, V, Agasiev, M, Ganjara, I, Gunji??, D, Veselinovi??, M, Babi??, T, S Chin, T, Shabbir, A, Kim, G, Crnjac, A, Samo, H, I D??ez del Val, Leturio, S, M Ram??n, J, M Dal Cero, Rif??, S, Rico, M, A Pagan Pomar, A Martinez Corcoles, J, L Rodicio Miravalles, J, A Pais, S, A Turienzo, S, S Alvarez, L, V Campos, P, G Rendo, A, S Garc??a, S, E P, G Santos, T Mart??nez, E, J Fern??ndez D??az, M, C Magad??n ??lvarez, V Concepci??n Mart??n, C D??az L??pez, A Rosat Rodrigo, E P??rez S??nchez, L, M Bail??n Cuadrado, C Tinoco Carrasco, E Choolani Bhojwani, P S??nchez, D, E Ahmed, M, Dzhendov, T, Lindberg, F, Ruteg??rd, M, Sundbom, M, Mickael, C, Colucci, N, Schnider, A, S, Er, Kurnaz, E, Turkyilmaz, S, Turkyilmaz, A, Yildirim, R, E Baki, B, Akkapulu, N, Karahan, O, Damburaci, N, Hardwick, R, Safranek, P, Sujendran, V, Bennett, J, Afzal, Z, Shrotri, M, Chan, B, Exarchou, K, Gilbert, T, Amalesh, T, Mukherjee, D, Mukherjee, S, H Wiggins, T, Kennedy, R, Mccain, S, Harris, A, Dobson, G, Davies, N, Wilson, I, Mayo, D, Bennett, D, Young, R, Manby, P, Blencowe, N, Schiller, M, Byrne, B, Mitton, D, Wong, V, Elshaer, A, Cowen, M, Menon, V, C Tan, L, Mclaughlin, E, Koshy, R, Sharp, C, Brewer, H, Das, N, Cox, M, W Al Khyatt, Worku, D, Iqbal, R, Walls, L, Mcgregor, R, Fullarton, G, Macdonald, A, Mackay, C, Craig, C, Dwerryhouse, S, Hornby, S, Jaunoo, S, Wadley, M, Baker, C, Saad, M, Kelly, M, Davies, A, F Di Maggio, Mistry, P, Singhal, R, Tucker, O, Kapoulas, S, Powell-Brett, S, Davis, P, Bromley, G, Watson, L, Verma, R, Ward, J, Shetty, V, Ball, C, Pursnani, K, Sarela, A, H Sue Ling, Mehta, S, Hayden, J, N, To, Palser, T, Hunter, D, Supramaniam, K, Butt, Z, Ahmed, A, Kumar, S, Chaudry, A, Moussa, O, Kordzadeh, A, Lorenzi, B, Wilson, M, Patil, P, Noaman, I, Willem, J, Bouras, G, Evans, R, Singh, M, Warrilow, H, Ahmad, A, Tewari, N, Yanni, F, Couch, J, Theophilidou, E, J Reilly, J, G van Boxel, Akbari, K, Zanotti, D, Sgromo, B, Sanders, G, Wheatley, T, Ariyarathenam, A, Reece-Smith, A, Humphreys, L, Choh, C, Carter, N, Knight, B, Pucher, P, Athanasiou, A, Tan, B, Abdulrahman, M, Vickers, J, Akhtar, K, Chaparala, R, Brown, R, M M, A Alasmar, Ackroyd, R, Patel, K, Tamhankar, A, Wyman, A, Walker, R, Grace, B, Abbassi, N, Slim, N, Ioannidi, L, Blackshaw, G, Havard, T, Escofet, X, Powell, A, Owera, A, Rashid, F, Jambulingam, P, Padickakudi, J, Ben-Younes, H, Mccormack, K, A Makey, I, K Karush, M, W Seder, C, J Liptay, M, Chmielewski, G, L Rosato, E, C Berger, A, Zheng, R, Okolo, E, Singh, A, D Scott, C, J Weyant, M, D Mitchell, J, Surgery, Evans, RPT, Hodson, J, Kamarajah, SK, Griffiths, EA, Singh, P, Alderson, D, Bundred, J, Gossage, J, Jefferies, B, McKay, S, Mohamed, I, Nepogodiev, D, Siaw-Acheampong, K, van Hillegersberg, R, Vohra, R, Wanigasooriya, K, Whitehouse, T, Gjata, A, Moreno, JI, Takeda, FR, Kidane, B, Castro, RG, Harustiak, T, Bekele, A, Kechagias, A, Gockel, I, Kennedy, A, Da Roit, A, Bagajevas, A, Azagra, JS, Mahendran, HA, Mejia-Fernandez, L, Wijnhoven, BPL, El Kafsi, J, Sayyed, RH, Sousa, M, Sampaio, AS, Negoi, I, Blanco, R, Wallner, B, Schneider, PM, Hsu, PK, Isik, A, Gananadha, S, Wills, V, Devadas, M, Duong, C, Talbot, M, Hii, MW, Jacobs, R, Andreollo, NA, Johnston, B, Darling, G, Isaza-Restrepo, A, Rosero, G, Arias-Amezquita, F, Raptis, D, Gaedcke, J, Reim, D, Izbicki, J, Egberts, JH, Dikinis, S, Kjaer, DW, Larsen, MH, Achiam, MP, Saarnio, J, Theodorou, D, Liakakos, T, Korkolis, DP, Robb, WB, Collins, C, Murphy, T, Reynolds, J, Tonini, V, Migliore, M, Bonavina, L, Valmasoni, M, Bardini, R, Weindelmayer, J, Terashima, M, White, RE, Alghunaim, E, Elhadi, M, Leon-Takahashi, AM, Medina-Franco, H, Lau, PC, Okonta, KE, Heisterkamp, J, Rosman, C, Beban, G, Babor, R, Gordon, A, Rossaak, JI, Pal, KMI, Qureshi, AU, Naqi, SA, Syed, AA, Barbosa, J, Vicente, CS, Leite, J, Freire, J, Casaca, R, Costa, RCT, Scurtu, RR, Mogoanta, SS, Bolca, C, Constantinoiu, S, Sekhniaidze, D, So, JBY, Gacvski, G, Loureiro, C, Pera, M, Bianchi, A, Gijon, MM, Fernandez, JM, Carrera, MST, Vallve-Bernal, M, Pascual, MAC, Elmahi, S, Halldestam, I, Hedberg, J, Monig, S, Gutknecht, S, Tez, M, Guner, A, Tirnaksiz, TB, Colak, E, Sevinc, B, Hindmarsh, A, Khan, I, Khoo, D, Byrom, R, Gokhale, J, Wilkerson, P, Jain, P, Chan, D, Robertson, K, Iftikhar, S, Skipworth, R, Forshaw, M, Higgs, S, Nijjar, R, Viswanath, YKS, Turner, P, Dexter, S, Boddy, A, Allum, WH, Oglesby, S, Cheong, E, Beardsmore, D, Maynard, N, Berrisford, R, Mercer, S, Puig, S, Melhado, R, Kelty, C, Underwood, T, Dawas, K, Lewis, W, Al-Bahrani, A, Bryce, G, Thomas, M, Arndt, AT, Palazzo, F, Meguid, RA, Fergusson, J, Beenen, E, Mosse, C, Salim, J, Cheah, S, Wright, T, Cerdeira, MP, McQuillan, P, Richardson, M, Liem, H, Spillane, J, Yacob, M, Albadawi, F, Thorpe, T, Dingle, A, Cabalag, C, Loi, K, Fisher, OM, Ward, S, Read, M, Johnson, M, Bassari, R, Bui, H, Cecconello, I, Sallum, RAA, da Rocha, JRM, Lopes, LR, Tercioti, V, Coelho, JDS, Ferrer, JAP, Buduhan, G, Tan, L, Srinathan, S, Shea, P, Yeung, J, Allison, F, Carroll, P, Vargas-Barato, F, Gonzalez, F, Ortega, J, Nino-Torres, L, Beltran-Garcia, TC, Castilla, L, Pineda, M, Bastidas, A, Gomez-Mayorga, J, Cortes, N, Cetares, C, Caceres, S, Duarte, S, Pazdro, A, Snajdauf, M, Faltova, H, Sevcikova, M, Mortensen, PB, Katballe, N, Ingemann, T, Morten, B, Kruhlikava, I, Ainswort, AP, Stilling, NM, Eckardt, J, Holm, J, Thorsteinsson, M, Siemsen, M, Brandt, B, Nega, B, Teferra, E, Tizazu, A, Kauppila, JS, Koivukangas, V, Merilainen, S, Gruetzmann, R, Krautz, C, Weber, G, Golcher, H, Emons, G, Azizian, A, Ebeling, M, Niebisch, S, Kreuser, N, Albanese, G, Hesse, J, Volovnik, L, Boecher, U, Reeh, M, Triantafyllou, S, Schizas, D, Michalinos, A, Baili, E, Mpoura, M, Charalabopoulos, A, Manatakis, DK, Balalis, D, Bolger, J, Baban, C, Mastrosimone, A, McAnena, O, Quinn, A, Suilleabhain, CBO, Hennessy, MM, Ivanovski, I, Khizer, H, Ravi, N, Donlon, N, Cervellera, M, Vaccari, S, Bianchini, S, Sartarelli, L, Asti, E, Bernardi, D, Merigliano, S, Provenzano, L, Scarpa, M, Saadeh, L, Salmaso, B, De Manzoni, G, Giacopuzzi, S, La Mendola, R, De Pasqual, CA, Tsubosa, Y, Niihara, M, Irino, T, Makuuchi, R, Ishii, K, Mwachiro, M, Fekadu, A, Odera, A, Mwachiro, E, AlShehab, D, Ahmed, HA, Shebani, AO, Elhadi, A, Elnagar, FA, Elnagar, HF, Makkai-Popa, ST, Wong, LF, Yunrong, T, Thanninalai, S, Aik, HC, Soon, PW, Huei, TJ, Basave, HNL, Cortes-Gonzalez, R, Lagarde, SM, van Lanschot, JJB, Cords, C, Jansen, WA, Martijnse, I, Matthijsen, R, Bouwense, S, Klarenbeek, B, Verstegen, M, van Workum, F, Ruurda, JP, van der Veen, A, van den Berg, JW, Evenett, N, Johnston, P, Patel, R, MacCormick, A, Young, M, Smith, B, Ekwunife, C, Memon, AH, Shaikh, K, Wajid, A, Khalil, N, Haris, M, Mirza, ZU, Qudus, SBA, Sarwar, MZ, Shehzadi, A, Raza, A, Jhanzaib, MH, Farmanali, J, Zakir, Z, Shakeel, O, Nasir, I, Khattak, S, Baig, M, Noor, MA, Ahmed, HH, Naeem, A, Pinho, AC, da Silva, R, Bernardes, A, Campos, JC, Matos, H, Braga, T, Monteiro, C, Ramos, P, Cabral, F, Gomes, MP, Martins, PC, Correia, AM, Videira, JF, Ciuce, C, Drasovean, R, Apostu, R, Paitici, S, Racu, AE, Obleaga, CV, Beuran, M, Stoica, B, Ciubotaru, C, Negoita, V, Cordos, I, Birla, RD, Predescu, D, Hoara, PA, Tomsa, R, Shneider, V, Agasiev, M, Ganjara, I, Gunjic, D, Veselinovic, M, Babic, T, Chin, TS, Shabbir, A, Kim, G, Crnjac, A, Samo, H, del Val, ID, Leturio, S, Ramon, JM, Dal Cero, M, Rifa, S, Rico, M, Pomar, AP, Corcoles, JAM, Miravalles, JLR, Pais, SA, Turienzo, SA, Alvarez, LS, Campos, PV, Rendo, AG, Garcia, SS, Santos, EPG, Martinez, ET, Diaz, MJF, Alvarez, CM, Martin, VC, Lopez, CD, Rodrigo, AR, Sanchez, LEP, Cuadrado, MB, Carrasco, CT, Bhojwani, EC, Sanchez, DP, Ahmed, ME, Dzhendov, T, Lindberg, F, Rutegard, M, Sundbom, M, Mickael, C, Colucci, N, Schnider, A, Er, S, Kurnaz, E, Turkyilmaz, S, Turkyilmaz, A, Yildirim, R, Baki, BE, Akkapulu, N, Karahan, O, Damburaci, N, Hardwick, R, Safranek, P, Sujendran, V, Bennett, J, Afzal, Z, Shrotri, M, Chan, B, Exarchou, K, Gilbert, T, Amalesh, T, Mukherjee, D, Mukherjee, S, Wiggins, TH, Kennedy, R, McCain, S, Harris, A, Dobson, G, Davies, N, Wilson, I, Mayo, D, Bennett, D, Young, R, Manby, P, Blencowe, N, Schiller, M, Byrne, B, Mitton, D, Wong, V, Elshaer, A, Cowen, M, Menon, V, Tan, LC, McLaughlin, E, Koshy, R, Sharp, C, Brewer, H, Das, N, Cox, M, Al Khyatt, W, Worku, D, Iqbal, R, Walls, L, McGregor, R, Fullarton, G, Macdonald, A, MacKay, C, Craig, C, Dwerryhouse, S, Hornby, S, Jaunoo, S, Wadley, M, Baker, C, Saad, M, Kelly, M, Davies, A, Di Maggio, F, Mistry, P, Singhal, R, Tucker, O, Kapoulas, S, Powell-Brett, S, Davis, P, Bromley, G, Watson, L, Verma, R, Ward, J, Shetty, V, Ball, C, Pursnani, K, Sarela, A, Ling, HS, Mehta, S, Hayden, J, To, N, Palser, T, Hunter, D, Supramaniam, K, Butt, Z, Ahmed, A, Kumar, S, Chaudry, A, Moussa, O, Kordzadeh, A, Patil, P, Noaman, I, Willem, J, Bouras, G, Evans, R, Singh, M, Warrilow, H, Ahmad, A, Tewari, N, Yanni, F, Couch, J, Theophilidou, E, Reilly, JJ, van Boxel, G, Akbari, K, Zanotti, D, Sgromo, B, Sanders, G, Wheatley, T, Ariyarathenam, A, Reece-Smith, A, Humphreys, L, Choh, C, Carter, N, Knight, B, Pucher, P, Athanasiou, A, Tan, B, Abdulrahman, M, Vickers, J, Akhtar, K, Chaparala, R, Brown, R, Alasmar, MMA, Ackroyd, R, Patel, K, Tamhankar, A, Wyman, A, Walker, R, Grace, B, Abbassi, N, Slim, N, Ioannidi, L, Blackshaw, G, Havard, T, Escofet, X, Powell, A, Owera, A, Rashid, F, Jambulingam, P, Padickakudi, J, Ben-Younes, H, McCormack, K, Makey, IA, Karush, MK, Seder, CW, Liptay, MJ, Chmielewski, G, Rosato, EL, Berger, AC, Zheng, R, Okolo, E, Singh, A, Scott, CD, Weyant, MJ, and Mitchell, JD

Subjects
squamous cell carcinoma, surgical mortality, AcademicSubjects/MED00910, Esophageal Neoplasms, SURGERY, IMPACT, clinical outcome, Anastomotic Leak, Adult, aged, anastomosis leakage, article, cancer staging, cardiovascular disease assessment, Charlson Comorbidity Index, cohort analysis, ECOG Performance Status, esophagectomy, esophagus cancer, female, follow up, histology, human, intensive care unit, length of stay, major clinical study, male, middle aged, mortality, necrosis, neoadjuvant chemoradiotherapy, neoadjuvant chemotherapy, observational study, postoperative complication, postoperative period, reoperation, surgical technique, Cohort Studies, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Surgical, Anastomosis, Surgical, General Medicine, Original Article, AcademicSubjects/MED00010, Life Sciences & Biomedicine, Anastomosis, SOCIETY, Bjs/5, trainee, oesophagectomy, trainee, Humans, Esophagectomy, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, RESIDENT INVOLVEMENT, Science & Technology, SURGICAL OUTCOMES
Abstract

Background The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. Methods Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. Results Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). Conclusion Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery., The aim of this study was to determine the impact of trainee involvement in oesophagectomy on perioperative outcomes in the international multicentre Oesophago-Gastric Anastomosis Audit (OGAA). Analysis of 2232 oesophagectomies has shown that trainee involvement did not negatively impact perioperative outcomes.

Published
2022

35. Textbook outcome following oesophagectomy for cancer: international cohort study

Author

Kamarajah, S. K., Evans, R. P. T., Nepogodiev, D., Hodson, J., Bundred, J. R., Gockel, I., Gossage, J. A., Isik, A., Kidane, B., Mahendran, H. A., Negoi, I., Okonta, K. E., Sayyed, R., van Hillegersberg, R., Vohra, R. S., Wijnhoven, B. P. L., Singh, P., Griffiths, E. A., Alderson, D., Bundred, J., Gossage, J., Jefferies, B., Mckay, S., Mohamed, I., Siaw-Acheampong, K., Vohra, R., Wanigasooriya, K., Whitehouse, T., Gjata, A., Moreno, J. I., Takeda, F. R., Guevara Castro, R., Harustiak, T., Bekele, A., Kechagias, A., Kennedy, A., Da Roit, A., Bagajevas, A., Azagra, J. S., Mej??a-Fern??ndez, L., El Kafsi, J., Sayyed, R. H., Sousa M, M., Sampaio, A. S., Blanco, R., Wallner, B., Schneider, P. M., Hsu, P. K., Gananadha, S., Wills, V., Devadas, M., Duong, C., Talbot, M., Hii, M. W., Jacobs, R., Andreollo, N. A., Johnston, B., Darling, G., Isaza-Restrepo, A., Rosero, G., Arias-Am??zquita, F., Raptis, D., Gaedcke, J., Reim, D., Izbicki, J., Egberts, J. H., Dikinis, S., Kjaer, D. W., Larsen, M. H., Achiam, M. P., Saarnio, J., Theodorou, D., Liakakos, T., Korkolis, D. P., Robb, W. B., Collins, C., Murphy, T., Reynolds, J., Tonini, V., Migliore, M., Bonavina, L., Valmasoni, M., Bardini, R., Weindelmayer, J., Terashima, M., White, R. E., Alghunaim, E., Elhadi, M., Leon-Takahashi, A. M., Medina-Franco, H., Lau, P. C., Heisterkamp, J., Rosman, C., Beban, G., Babor, R., Gordon, A., Rossaak, J. I., Pal, K. M. I., Qureshi, A. U., Naqi, S. A., Syed, A. A., Barbosa, J., Vicente, C. S., Leite, J., Freire, J., Casaca, R., Costa, R. C. T., Scurtu, R. R., Mogoanta, S. S., Bolca, C., Constantinoiu, S., Sekhniaidze, D., Bjelovi??, M., J. B. Y., So, Ga??evski, G., Loureiro, C., Pera, M., Bianchi, A., Moreno Gij??n, M., Fern??ndez, J. Mart??n., Trugeda Carrera, M. S., Vallve-Bernal, M., C??tores Pascual, M. A., Elmahi, S., Halldestam, I., Hedberg, J., M??nig, S., Gutknecht, S., Tez, M., Guner, A., Tirnaksiz, M. B., Colak, E., Sevin??, B., Hindmarsh, A., Khan, I., Khoo, D., Byrom, R., Gokhale, J., Wilkerson, P., Jain, P., Chan, D., Robertson, K., Iftikhar, S., Skipworth, R., Forshaw, M., Higgs, S., Nijjar, R., Viswanath, Y. K. S., Turner, P., Dexter, S., Boddy, A., Allum, W. H., Oglesby, S., Cheong, E., Beardsmore, D., Maynard, N., Berrisford, R., Mercer, S., Puig, S., Melhado, R., Kelty, C., Underwood, T., Dawas, K., Lewis, W., Bryce, G., Thomas, M., Arndt, A. T., Palazzo, F., Meguid, R. A., Fergusson, J., Beenen, E., Mosse, C., Salim, J., Cheah, S., Wright, T., Cerdeira, M. P., Mcquillan, P., Richardson, M., Liem, H., Spillane, J., Yacob, M., Albadawi, F., Thorpe, T., Dingle, A., Cabalag, C., Loi, K., Fisher, O. M., Ward, S., Read, M., Johnson, M., Bassari, R., Bui, H., Cecconello, I., Sallum, R. A. A., da Rocha, J. R. M., Lopes, L. R., Tercioti Jr, V., Coelho, J. D. S., Ferrer, J. A. P., Buduhan, G., Tan, L., Srinathan, S., Shea, P., Yeung, J., Allison, F., Carroll, P., Vargas-Barato, F., Gonzalez, F., Ortega, J., Nino-Torres, L., Beltr??n-Garc??a, T. C., Castilla, L., Pineda, M., Bastidas, A., G??mez-Mayorga, J., Cort??s, N., Cetares, C., Caceres, S., Duarte, S., Pazdro, A., Snajdauf, M., Faltova, H., Sevcikova, M., Mortensen, P. B., Katballe, N., Ingemann, T., Morten, B., Kruhlikava, I., Ainswort, A. P., Stilling, N. M., Eckardt, J., Holm, J., Thorsteinsson, M., Siemsen, M., Brandt, B., Nega, B., Teferra, E., Tizazu, A., Kauppila, J. H., Koivukangas, V., Meril??inen, S., Gruetzmann, R., Krautz, C., Weber, G., Golcher, H., Emons, G., Azizian, A., Ebeling, M., Niebisch, S., Kreuser, N., Albanese, G., Hesse, J., Volovnik, L., Boecher, U., Reeh, M., Triantafyllou, S., Schizas, D., Michalinos, A., Balli, E., Mpoura, M., Charalabopoulos, A., Manatakis, D. K., Balalis, D., Bolger, J., Baban, C., Mastrosimone, A., Mcanena, O., Quinn, A., S??illeabh??in, C. B., Hennessy, M. M., Ivanovski, I., Khizer, H., Ravi, N., Donlon, N., Cervellera, M., Vaccari, S., Bianchini, S., Asti, E., Bernardi, D., Merigliano, S., Provenzano, L., Scarpa, M., Saadeh, L., Salmaso, B., De Manzoni, G., Giacopuzzi, S., La Mendola, R., De Pasqual, C. A., Tsubosa, Y., Niihara, M., Irino, T., Makuuchi, R., Ishii K, K., Mwachiro, M., Fekadu, A., Odera, A., Mwachiro, E., Alshehab, D., Ahmed, H. A., Shebani, A. O., Elhadi, A., Elnagar, F. A., Elnagar, H. F., Makkai-Popa, S. T., Wong, L. F., Tan, Y. R., Thannimalai, S., C. A., Ho, Pang, W. S., Tan, J. H., Basave, H. N. L., Cort??s-Gonz??lez, R., Lagarde, S. M., van Lanschot, J. J. B., Cords, C., Jansen, W. A., Martijnse, I., Matthijsen, R., Bouwense, S., Klarenbeek, B., Verstegen, M., van Workum, F., Ruurda, J. P., van der Sluis, P. C., de Maat, M., Evenett, N., Johnston, P., Patel, R., Maccormick, A., Smith, B., Ekwunife, C., Memon, A. H., Shaikh, K., Wajid, A., Khalil, N., Haris, M., Mirza, Z. U., Qudus, S. B. A., Sarwar, M. Z., Shehzadi, A., Raza, A., Jhanzaib, M. H., Farmanali, J., Zakir, Z., Shakeel, O., Nasir, I., Khattak, S., Baig, M., Noor, M. A., Ahmed, H. H., Naeem, A., Pinho, A. C., da Silva, R., Bernardes, A., Campos, J. C., Matos, H., Braga, T., Monteiro, C., Ramos, P., Cabral, F., Gomes, M. P., Martins, P. C., Correia, A. M., Videira, J. F., Ciuce, C., Drasovean, R., Apostu, R., Paitici, S., Racu, A. E., Obleaga, C. V., Beuran, M., Stoica, B., Ciubotaru, C., Negoita, V., Cordos, I., Birla, R. D., Predescu, D., Hoara, P. A., Tomsa, R., Shneider, V., Agasiev, M., Ganjara, I., Gunji??, D., Veselinovi??, M., Babi??, T., Chin, T. S., Shabbir, A., Kim, G., Crnjac, A., Samo, H., D??ez del Val, I., Leturio, S., Ram??n, J. M., Dal Cero, M., Rif??, S., Rico, M., Pagan Pomar, A., Martinez Corcoles, J. A., Rodicio Miravalles, J. L., Pais, S. A., Turienzo, S. A., Alvarez, L. S., Campos, P. V., Rendo, A. G., Garc??a, S. S., Santos, E. P. G., Mart??nez, E. T., Fern??ndez D??az, M. J., lvarez, C. Magad??n., Mart??n, V. Concepci??n., D??az L??pez, C., Rosat Rodrigo, A., P??rez S??nchez, L. E., Cuadrado, M. Bail??n., Tinoco Carrasco, C., Choolani Bhojwani, E., S??nchez, D. P., Ahmed, M. E., Dzhendov, T., Lindberg, F., Ruteg??rd, M., Sundbom, M., Mickael, C., Colucci, N., Schnider, A., Er, S., Kurnaz, E., Turkyilmaz, S., Turkyilmaz, A., Yildirim, R., Baki, B. E., Akkapulu, N., Karahan, O., Damburaci, N., Hardwick, R., Safranek, P., Sujendran, V., Bennett, J., Afzal, Z., Shrotri, M., Chan, B., Exarchou, K., Gilbert, T., Amalesh, T., Mukherjee, D., Mukherjee, S., Wiggins, T. H., Kennedy, R., Mccain, S., Harris, A., Dobson, G., Davies, N., Wilson, I., Mayo, D., Bennett, D., Young, R., Manby, P., Blencowe, N., Schiller, M., Byrne, B., Mitton, D., Wong, V., Elshaer, A., Cowen, M., Menon, V., Tan, L. C., Mclaughlin, E., Koshy, R., Sharp, C., Brewer, H., Das, N., Cox, M., Al Khyatt, W., Worku, D., Iqbal, R., Walls, L., Mcgregor, R., Fullarton, G., Macdonald, A., Mackay, C., Craig, C., Dwerryhouse, S., Hornby, S., Jaunoo, S., Wadley, M., Baker, C., Saad, M., Kelly, M., Davies, A., Di Maggio, F., Mistry, P., Singhal, R., Tucker, O., Kapoulas, S., Powell-Brett, S., Davis, P., Bromley, G., Watson, L., Verma, R., Ward, J., Shetty, V., Ball, C., Pursnani, K., Sarela, A., Sue Ling, H., Mehta, S., Hayden, J., To, N., Palser, T., Hunter, D., Supramaniam, K., Butt, Z., Ahmed, A., Kumar, S., Chaudry, A., Moussa, O., Kordzadeh, A., Lorenzi, B., Wilson, M., Patil, P., Noaman, I., Bouras, G., Evans, R., Singh, M., Warrilow, H., Ahmad, A., Tewari, N., Yanni, F., Couch, J., Theophilidou, E., Reilly, J. J., van Boxel, G., Akbari, K., Zanotti, D., Sanders, G., Wheatley, T., Ariyarathenam, A., Reece-Smith, A., Humphreys, L., Choh, C., Carter, N., Knight, B., Pucher, P., Athanasiou, A., Tan, B., Abdulrahman, M., Vickers, J., Akhtar, K., Chaparala, R., Brown, R., Alasmar, M. M. A., Ackroyd, R., Patel, K., Tamhankar, A., Wyman, A., Walker, R., Grace, B., Abbassi, N., Slim, N., Ioannidi, L., Blackshaw, G., Havard, T., Escofet, X., Powell, A., Owera, A., Rashid, F., Jambulingam, P., Padickakudi, J., Ben-Younes, H., Mccormack, K., Makey, I. A., Karush, M. K., Seder, C. W., Liptay, M. J., Chmielewski, G., Rosato, E. L., Berger, A. C., Zheng, R., Okolo, E., Singh, A., Scott, C. D., Weyant, M. J., Mitchell, J. D., and Surgery

Subjects
Male, Textbook, MINIMALLY INVASIVE ESOPHAGECTOMY, Minimally Invasive Surgical Procedures/methods, Esophageal Neoplasms, SURGERY, Anastomosis, LYMPH-NODE RETRIEVAL, Anastomosis, Surgical, education, Anastomosis, Surgical/adverse effects, Esophageal Neoplasms/pathology, Esophagectomy/methods, Cohort Studies, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Treatment Outcome, SDG 3 - Good Health and Well-being, Humans, Minimally Invasive Surgical Procedures, Esophagectomy, Surgical, esophagectomy, Surgery, Textbook, esophagectomy, esophageal cancer, esophageal cancer
Abstract

Background Textbook outcome has been proposed as a tool for the assessment of oncological surgical care. However, an international assessment in patients undergoing oesophagectomy for oesophageal cancer has not been reported. This study aimed to assess textbook outcome in an international setting. Methods Patients undergoing curative resection for oesophageal cancer were identified from the international Oesophagogastric Anastomosis Audit (OGAA) from April 2018 to December 2018. Textbook outcome was defined as the percentage of patients who underwent a complete tumour resection with at least 15 lymph nodes in the resected specimen and an uneventful postoperative course, without hospital readmission. A multivariable binary logistic regression model was used to identify factors independently associated with textbook outcome, and results are presented as odds ratio (OR) and 95 per cent confidence intervals (95 per cent c.i.). Results Of 2159 patients with oesophageal cancer, 39.7 per cent achieved a textbook outcome. The outcome parameter ‘no major postoperative complication’ had the greatest negative impact on a textbook outcome for patients with oesophageal cancer, compared to other textbook outcome parameters. Multivariable analysis identified male gender and increasing Charlson comorbidity index with a significantly lower likelihood of textbook outcome. Presence of 24-hour on-call rota for oesophageal surgeons (OR 2.05, 95 per cent c.i. 1.30 to 3.22; P = 0.002) and radiology (OR 1.54, 95 per cent c.i. 1.05 to 2.24; P = 0.027), total minimally invasive oesophagectomies (OR 1.63, 95 per cent c.i. 1.27 to 2.08; P < 0.001), and chest anastomosis above azygous (OR 2.17, 95 per cent c.i. 1.58 to 2.98; P < 0.001) were independently associated with a significantly increased likelihood of textbook outcome. Conclusion Textbook outcome is achieved in less than 40 per cent of patients having oesophagectomy for cancer. Improvements in centralization, hospital resources, access to minimal access surgery, and adoption of newer techniques for improving lymph node yield could improve textbook outcome.

Published
2022

38. Electrical stimulation therapy of the lower oesophageal sphincter for refractory gastro-oesophageal reflux disease – interim results of an international multicentre trial

Author

Kappelle, W. F. W., Bredenoord, A. J., Conchillo, J. M., Ruurda, J. P., Bouvy, N. D., van Berge Henegouwen, M. I., Chiu, P. W., Booth, M., Hani, A., Reddy, D. N., Bogte, A., Smout, A. J. P. M., Wu, J. C., Escalona, A., Valdovinos, M. A., Torres-Villalobos, G., and Siersema, P. D.

Published
2015
Full Text
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39. Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study

Author

Kamarajah, S. K. Nepogodiev, D. Bekele, A. Cecconello, I. and Evans, R. P. T. Guner, A. Gossage, J. A. Harustiak, T. and Hodson, J. Isik, A. Kidane, B. Leon-Takahashi, A. M. and Mahendran, H. A. Negoi, I. Okonta, K. E. Rosero, G. and Sayyed, R. H. Singh, P. Takeda, F. R. van Hillegersberg, R. and Vohra, R. S. White, R. E. Griffiths, E. A. Alderson, D. and Bundred, J. Evans, R. P. T. Gossage, J. Griffiths, E. A. and Jefferies, B. Kamarajah, S. K. McKay, S. Mohamed, I. and Nepogodiev, D. Siaw-Acheampong, K. Singh, P. van Hillegersberg, R. Vohra, R. Wanigasooriya, K. Whitehouse, T. and Gjata, A. Moreno, J. I. Takeda, F. R. Kidane, B. and Guevara, Castro R. Harustiak, T. Bekele, A. Kechagias, A. and Gockel, I. Kennedy, A. Da Roit, A. Bagajevas, A. and Azagra, J. S. Mahendran, H. A. Mejia-Fernandez, L. and Wijnhoven, B. P. L. El Kafsi, J. Sayyed, R. H. Sousa, M. and Sampaio, A. S. Negoi, I. Blanco, R. Wallner, B. and Schneider, P. M. Hsu, P. K. Isik, A. Gananadha, S. and Wills, V. Devadas, M. Duong, C. Talbot, M. Hii, M. W. and Jacobs, R. Andreollo, N. A. Johnston, B. Darling, G. and Isaza-Restrepo, A. Rosero, G. Arias-Amezquita, F. Raptis, D. and Gaedcke, J. Reim, D. Izbicki, J. Egberts, J. H. and Dikinis, S. Kjaer, D. W. Larsen, M. H. Achiam, M. P. and Saarnio, J. Theodorou, D. Liakakos, T. Korkolis, D. P. and Robb, W. B. Collins, C. Murphy, T. Reynolds, J. Tonini, V. Migliore, M. Bonavina, L. Valmasoni, M. Bardini, R. and Weindelmayer, J. Terashima, M. White, R. E. Alghunaim, E. Elhadi, M. Leon-Takahashi, A. M. Medina-Franco, H. and Lau, P. C. Okonta, K. E. Heisterkamp, J. Rosman, C. van Hillegersberg, R. Beban, G. Babor, R. Gordon, A. and Rossaak, J. I. Pal, K. M. I. Qureshi, A. U. Naqi, S. A. and Syed, A. A. Barbosa, J. Vicente, C. S. Leite, J. Freire, J. Casaca, R. Costa, R. C. T. Scurtu, R. R. Mogoanta, S. S. Bolca, C. Constantinoiu, S. Sekhniaidze, D. Bjelovic, M. So, J. B. Y. Gacevski, G. Loureiro, C. Pera, M. and Bianchi, A. Moreno, Gijon M. Martin Fernandez, J. Carrera, M. S. Trugeda Vallve-Bernal, M. Pascual, M. A. Citores and Elmahi, S. Halldestam, I. Hedberg, J. Monig, S. and Gutknecht, S. Tez, M. Guner, A. Tirnaksiz, M. B. Colak, E. Sevinc, B. Hindmarsh, A. Khan, I. Khoo, D. Byrom, R. Gokhale, J. Wilkerson, P. Jain, P. Chan, D. and Robertson, K. Iftikhar, S. Skipworth, R. Forshaw, M. and Higgs, S. Gossage, J. Nijjar, R. Viswanath, Y. K. S. and Turner, P. Dexter, S. Boddy, A. Allum, W. H. Oglesby, S. and Cheong, E. Beardsmore, D. Vohra, R. Maynard, N. and Berrisford, R. Mercer, S. Puigt, S. Melhadot, R. Kelty, C. Underwood, T. Dawas, K. Lewis, W. Al-Bahrani, A. and Bryce, G. Thomas, M. Arndt, A. T. Palazzo, F. Meguid, R. A. Fergusson, J. Beenen, E. Mosse, C. Salim, J. and Cheah, S. Wright, T. Cerdeira, M. P. McQuillan, P. and Richardson, M. Liem, H. Spillane, J. Yacob, M. Albadawi, F. Thorpe, T. Dingle, A. Cabalag, C. Loi, K. Fisher, O. M. Ward, S. Read, M. Johnson, M. Bassari, R. Bui, H. Cecconello, I. Sallum, R. A. A. da Rocha, J. R. M. and Lopes, L. R. Tercioti, Jr., V. Coelho, J. D. Ferrer, J. A. P. Buduhan, G. Tan, L. Srinathan, S. Shea, P. Yeung, J. Allison, F. Carroll, P. Vargas-Barato, F. Gonzalez, F. Ortega, J. Nino-Torres, L. Beltran-Garcia, T. C. and Castilla, L. Pineda, M. Bastidas, A. Gomez-Mayorga, J. and Cortes, N. Cetares, C. Caceres, S. Duarte, S. Pazdro, A. and Snajdauf, M. Faltova, H. Sevcikova, M. Mortensen, P. B. and Katballe, N. Ingemann, T. Morten, B. Kruhlikava, I. and Ainswort, A. P. Stilling, N. M. Eckardt, J. Holm, J. and Thorsteinsson, M. Siemsen, M. Brandt, B. Nega, B. and Teferra, E. Tizazu, A. Kauppila, J. H. Koivukangas, V. and Merilainen, S. Gruetzmann, R. Krautz, C. Weber, G. and Golcher, H. Emons, G. Azizian, A. Ebeling, M. Niebisch, S. Kreuser, N. Albanese, G. Hesse, J. Volovnik, L. and Boecher, U. Reeh, M. Triantafyllou, S. Schizas, D. and Michalinos, A. Mpali, E. Mpoura, M. Charalabopoulos, A. and Manatakis, D. K. Balalis, D. Bolger, J. Baban, C. and Mastrosimone, A. McAnena, O. Quinn, A. Suilleabhain, C. B. O. Hennessy, M. M. Ivanovski, I. Khizer, H. Ravi, N. and Donlon, N. Cervellera, M. Vaccari, S. Bianchini, S. and Sartarelli, L. Asti, E. Bernardi, D. Merigliano, S. and Provenzano, L. Scarpa, M. Saadeh, L. Salmaso, B. De Manzoni, G. Giacopuzzi, S. La Mendola, R. De Pasqual, C. A. and Tsubosa, Y. Niihara, M. Irino, T. Makuuchi, R. and Ishii, K. Mwachiro, M. Fekadu, A. Odera, A. Mwachiro, E. and AlShehab, D. Ahmed, H. A. Shebani, A. O. Elhadi, A. and Elnagar, F. A. Elnagar, H. F. Makkai-Popa, S. T. Wong, L. F. and Tan, Y. R. Thannimalai, S. Ho, C. A. Pang, W. S. and Tan, J. H. Basave, H. N. L. Cortes-Gonzalez, R. Lagarde, S. M. van Lanschot, J. J. B. Cords, C. Jansen, W. A. and Martijnse, I. Matthijsen, R. Bouwense, S. Klarenbeek, B. and Verstegen, M. van Workum, F. Ruurda, J. P. van der Sluis, P. C. de Maat, M. Evenett, N. Johnston, P. Patel, R. and MacCormick, A. Young, M. Smith, B. Ekwunife, C. Memon, A. H. Shaikh, K. Wajid, A. Khalil, N. Haris, M. and Mirza, Z. U. Qudus, S. B. A. Sarwar, M. Z. Shehzadi, A. and Raza, A. Jhanzaib, M. H. Farmanali, J. Zakir, Z. and Shakeel, O. Nasir, I. Khattak, S. Baig, M. Noor, M. A. and Ahmed, H. H. Naeem, A. Pinho, A. C. da Silva, R. and Bernardes, A. Campos, J. C. Matos, H. Braga, T. and Monteiro, C. Ramos, P. Cabral, F. Gomes, M. P. Martins, P. C. Correia, A. M. Videira, J. F. Ciuce, C. Drasovean, R. Apostu, R. Ciuce, C. Paitici, S. Racu, A. E. and Obleaga, C. V. Beuran, M. Stoica, B. Ciubotaru, C. and Negoita, V. Cordos, I. Birla, R. D. Predescu, D. Hoara, P. A. Tomsa, R. Shneider, V. Agasiev, M. Ganjara, I. and Gunjic, D. Veselinovic, M. Babic, T. Chin, T. S. and Shabbir, A. Kim, G. Crnjac, A. Samo, H. Del Val, I. Diez and Leturio, S. Ramon, J. M. Dal Cero, M. Rifa, S. Rico, M. Pomar, A. Pagan Corcoles, J. A. Martinez Miravalles, J. L. Rodicio Pais, S. A. Turienzo, S. A. Alvarezt, L. S. and Alvarez, L. S. Campos, P. V. Rendo, A. G. Garcia, S. S. and Santos, E. P. G. Martinez, E. T. Fernandez, Diaz Mj Magadan, Alvarez C. Concepcion, Martin V. Diaz, Lopez C. Rosat, Rodrigo A. Perez, Sanchez L. E. Bailon, Cuadrado M. Tinoco, Carrasco C. Bhojwani, E. Choolani Sanchez, D. P. Ahmed, M. E. Dzhendov, T. Lindberg, F. Rutegard, M. Sundbom, M. and Mickael, C. Colucci, N. Schnider, A. Er, S. Kurnaz, E. Turkyilmaz, S. Turkyilmaz, A. Yildirim, R. Baki, B. E. Akkapulu, N. Karahan, O. Damburaci, N. Hardwickt, R. and Safranek, P. Sujendran, V. Bennett, J. Afzal, Z. and Shrotri, M. Chan, B. Exarchou, K. Gilbert, T. Amalesh, T. Mukherjee, D. Mukherjee, S. Wiggins, T. H. Kennedy, R. McCain, S. Harris, A. Dobson, G. Davies, N. and Wilson, I. Mayo, D. Bennett, D. Young, R. Manby, P. and Blencowe, N. Schiller, M. Byrne, B. Mitton, D. Wong, V. and Elshaer, A. Cowen, M. Menon, V. Tan, L. C. and McLaughlin, E. Koshy, R. Sharp, C. Brewer, H. Das, N. and Cox, M. Al Khyatt, W. Worku, D. Iqbal, R. Walls, L. and McGregor, R. Fullarton, G. Macdonald, A. MacKay, C. and Craig, C. Dwerryhouse, S. Hornby, S. Jaunoo, S. Wadley, M. Baker, C. Saad, M. Kelly, M. Davies, A. Di Maggio, F. McKay, S. Mistry, P. Singhal, R. Tucker, O. and Kapoulas, S. Powell-Brett, S. Davis, P. Bromley, G. and Watson, L. Verma, R. Ward, J. Shetty, V. Ball, C. and Pursnani, K. Sarela, A. Sue, Ling H. Mehta, S. Hayden, J. To, N. Palser, T. Hunter, D. Supramaniam, K. and Butt, Z. Ahmed, A. Kumar, S. Chaudry, A. Moussa, O. and Kordzadeh, A. Lorenzi, B. Wilson, M. Patil, P. Noaman, I. Willem, J. Bouras, G. Evans, R. Singh, M. and Warrilow, H. Ahmad, A. Tewari, N. Yanni, F. Couch, J. and Theophilidou, E. Reilly, J. J. Singh, P. van Boxel, Gijs and Akbari, K. Zanotti, D. Sgromo, B. Sanders, G. and Wheatley, T. Ariyarathenam, A. Reece-Smith, A. Humphreys, L. and Choh, C. Carter, N. Knight, B. Pucher, P. and Athanasiou, A. Mohamed, I. Tan, B. Abdulrahman, M. and Vickers, J. Akhtar, K. Chaparala, R. Brown, R. Alasmar, M. M. A. Ackroyd, R. Patel, K. Tamhankar, A. Wyman, A. and Walker, R. Grace, B. Abbassi, N. Slim, N. Ioannidi, L. Blackshaw, G. Havard, T. Escofet, X. Powell, A. and Owera, A. Rashid, F. Jambulingam, P. Padickakudi, J. and Ben-Younes, H. Mccormack, K. Makey, I. A. Karush, M. K. and Seder, C. W. Liptay, M. J. Chmielewski, G. Rosato, E. L. and Berger, A. C. Zheng, R. Okolo, E. Singh, A. Scott, C. D. and Weyant, M. J. Mitchell, J. D. Oesophago-Gastric Anastomotic

Abstract

Background: No evidence currently exists characterising global outcomes following major cancer surgery, including esophageal cancer. Therefore, this study aimed to characterise impact of high income countries (HIC) versus low and middle income countries (LMIC) on the outcomes following esophagectomy for esophageal cancer. Method: This international multi-center prospective study across 137 hospitals in 41 countries included patients who underwent an esophagectomy for esophageal cancer, with 90-day follow-up. The main explanatory variable was country income, defined according to the World Bank Data classification. The primary outcome was 90-day postoperative mortality, and secondary outcomes were composite leaks (anastomotic leak or conduit necrosis) and major complications (Clavien-Dindo Grade III-V). Multivariable generalized estimating equation models were used to produce adjusted odds ratios (ORs) and 95% confidence intervals (CI95%). Results: Between April 2018 to December 2018, 2247 patients were included. Patients from HIC were more significantly older, with higher ASA grade, and more advanced tumors. Patients from LMIC had almost three-fold increase in 90-day mortality, compared to HIC (9.4% vs 3.7%, p < 0.001). On adjusted analysis, LMIC were independently associated with higher 90-day mortality (OR: 2.31, CI95%: 1.17-4.55, p = 0.015). However, LMIC were not independently associated with higher rates of anastomotic leaks (OR: 1.06, CI95%: 0.57-1.99, p = 0.9) or major complications (OR: 0.85, CI95%: 0.54-1.32, p = 0.5), compared to HIC. Conclusion: Resections in LMIC were independently associated with higher 90-day postoperative mortality, likely reflecting a failure to rescue of these patients following esophagectomy, despite similar composite anastomotic leaks and major complication rates to HIC. These findings warrant further research, to identify potential issues and solutions to improve global outcomes following esophagectomy for cancer. (C) 2020 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Published
2021

40. Postoperative outcomes in oesophagectomy with trainee involvement

Author

Evans, R. P. T. Hodson, J. Kamarajah, S. K. Griffiths, E. A. and Singh, P. Alderson, D. Bundred, J. Gossage, J. and Jefferies, B. McKay, S. Mohamed, I Nepogodiev, D. and Siaw-Acheampong, K. van Hillegersberg, R. Vohra, R. and Wanigasooriya, K. Whitehouse, T. Gjata, A. Moreno, I, J. and Takeda, F. R. Kidane, B. Castro, R. Guevara Harustiak, T. and Bekele, A. Kechagias, A. Gockel, I Kennedy, A. Da Roit, A. Bagajevas, A. Azagra, J. S. Mahendran, H. A. and Mejia-Fernandez, L. Wijnhoven, B. P. L. El Kafsi, J. Sayyed, R. H. Sousa, M. Sampaio, A. S. Negoi, I Blanco, R. and Wallner, B. Schneider, P. M. Hsu, P. K. Isik, A. and Gananadha, S. Wills, V Devadas, M. Duong, C. Talbot, M. and Hii, M. W. Jacobs, R. Andreollo, N. A. Johnston, B. and Darling, G. Isaza-Restrepo, A. Rosero, G. Arias-Amezquita, F. Raptis, D. Gaedcke, J. Reim, D. Izbicki, J. and Egberts, J. H. Dikinis, S. Kjaer, D. W. Larsen, M. H. and Achiam, M. P. Saarnio, J. Theodorou, D. Liakakos, T. and Korkolis, D. P. Robb, W. B. Collins, C. Murphy, T. and Reynolds, J. Tonini, V Migliore, M. Bonavina, L. and Valmasoni, M. Bardini, R. Weindelmayer, J. Terashima, M. and White, R. E. Alghunaim, E. Elhadi, M. Leon-Takahashi, A. M. and Medina-Franco, H. Lau, P. C. Okonta, K. E. Heisterkamp, J. Rosman, C. Beban, G. Babor, R. Gordon, A. and Rossaak, I, J. Pal, I, K. M. Qureshi, A. U. Naqi, S. A. and Syed, A. A. Barbosa, J. Vicente, C. S. Leite, J. Freire, J. Casaca, R. Costa, R. C. T. Scurtu, R. R. Mogoanta, S. S. Bolca, C. Constantinoiu, S. Sekhniaidze, D. So, J. B. Y. Gacvski, G. Loureiro, C. Pera, M. Bianchi, A. and Gijon, M. Moreno Fernandez, J. Martin Carrera, M. S. Trugeda and Vallve-Bernal, M. Pascual, M. A. Citores Elmahi, S. and Halldestam, I Hedberg, J. Monig, S. Gutknecht, S. Tez, M. Guner, A. Tirnaksiz, T. B. Colak, E. Sevinc, B. and Hindmarsh, A. Khan, I Khoo, D. Byrom, R. Gokhale, J. and Wilkerson, P. Jain, P. Chan, D. Robertson, K. Iftikhar, S. Skipworth, R. Forshaw, M. Higgs, S. Nijjar, R. and Viswanath, Y. K. S. Turner, P. Dexter, S. Boddy, A. and Allum, W. H. Oglesby, S. Cheong, E. Beardsmore, D. and Maynard, N. Berrisford, R. Mercer, S. Puig, S. Melhado, R. Kelty, C. Underwood, T. Dawas, K. Lewis, W. and Al-Bahrani, A. Bryce, G. Thomas, M. Arndt, A. T. and Palazzo, F. Meguid, R. A. Fergusson, J. Beenen, E. and Mosse, C. Salim, J. Cheah, S. Wright, T. Cerdeira, M. P. and McQuillan, P. Richardson, M. Liem, H. Spillane, J. and Yacob, M. Albadawi, F. Thorpe, T. Dingle, A. Cabalag, C. and Loi, K. Fisher, O. M. Ward, S. Read, M. Johnson, M. and Bassari, R. Bui, H. Cecconello, I Sallum, R. A. A. and da Rocha, J. R. M. Lopes, L. R. Tercioti, Jr., V. Coelho, J. D. S. Ferrer, J. A. P. Buduhan, G. Tan, L. Srinathan, S. and Shea, P. Yeung, J. Allison, F. Carroll, P. and Vargas-Barato, F. Gonzalez, F. Ortega, J. Nino-Torres, L. and Beltran-Garcia, T. C. Castilla, L. Pineda, M. Bastidas, A. Gomez-Mayorga, J. Cortes, N. Cetares, C. Caceres, S. and Duarte, S. Pazdro, A. Snajdauf, M. Faltova, H. and Sevcikova, M. Mortensen, P. B. Katballe, N. Ingemann, T. and Morten, B. Kruhlikava, I Ainswort, A. P. Stilling, N. M. and Eckardt, J. Holm, J. Thorsteinsson, M. Siemsen, M. and Brandt, B. Nega, B. Teferra, E. Tizazu, A. Kauppila, J. S. Koivukangas, V Merilainen, S. Gruetzmann, R. Krautz, C. Weber, G. Golcher, H. Emons, G. Azizian, A. and Ebeling, M. Niebisch, S. Kreuser, N. Albanese, G. Hesse, J. Volovnik, L. Boecher, U. Reeh, M. Triantafyllou, S. and Schizas, D. Michalinos, A. Baili, E. Mpoura, M. and Charalabopoulos, A. Manatakis, D. K. Balalis, D. Bolger, J. and Baban, C. Mastrosimone, A. McAnena, O. Quinn, A. and Suilleabhain, C. B. O. Hennessy, M. M. Ivanovski, I. Khizer, H. Ravi, N. Donlon, N. Cervellera, M. Vaccari, S. and Bianchini, S. Sartarelli, L. Asti, E. Bernardi, D. and Merigliano, S. Provenzano, L. Scarpa, M. Saadeh, L. and Salmaso, B. De Manzoni, G. Giacopuzzi, S. La Mendola, R. and De Pasqual, C. A. Tsubosa, Y. Niihara, M. Irino, T. and Makuuchi, R. Ishii, K. Mwachiro, M. Fekadu, A. Odera, A. and Mwachiro, E. AlShehab, D. Ahmed, H. A. Shebani, A. O. and Elhadi, A. Elnagar, F. A. Elnagar, H. F. Makkai-Popa, S. T. Wong, L. F. Yunrong, T. Thanninalai, S. Aik, H. C. and Soon, P. W. Huei, T. J. Basave, H. N. L. and Cortes-Gonzalez, R. Lagarde, S. M. van Lanschot, J. J. B. and Cords, C. Jansen, W. A. Martijnse, I Matthijsen, R. and Bouwense, S. Klarenbeek, B. Verstegen, M. van Workum, F. and Ruurda, J. P. van der Veen, A. van den Berg, J. W. Evenett, N. Johnston, P. Patel, R. MacCormick, A. Young, M. and Smith, B. Ekwunife, C. Memon, A. H. Shaikh, K. Wajid, A. and Khalil, N. Haris, M. Mirza, Z. U. Qudus, S. B. A. and Sarwar, M. Z. Shehzadi, A. Raza, A. Jhanzaib, M. H. and Farmanali, J. Zakir, Z. Shakeel, O. Nasir, I Khattak, S. and Baig, M. Noor, M. A. Ahmed, H. H. Naeem, A. Pinho, A. C. da Silva, R. Bernardes, A. Campos, J. C. Matos, H. and Braga, T. Monteiro, C. Ramos, P. Cabral, F. Gomes, M. P. Martins, P. C. Correia, A. M. Videira, J. F. and Ciuce, C. Drasovean, R. Apostu, R. Paitici, S. Racu, A. E. Obleaga, V, C. Beuran, M. Stoica, B. Ciubotaru, C. and Negoita, V Cordos, I Birla, R. D. Predescu, D. and Hoara, P. A. Tomsa, R. Shneider, V Agasiev, M. Ganjara, I Gunjic, D. Veselinovic, M. Babic, T. Chin, T. S. and Shabbir, A. Kim, G. Crnjac, A. Samo, H. del Val, I. Diez and Leturio, S. Ramon, J. M. Dal Cero, M. Rifa, S. Rico, M. Pomar, A. Pagan Corcoles, J. A. Martinez Miravalles, J. L. Rodicio Pais, S. A. Turienzo, S. A. Alvarez, L. S. and Campos, V, P. Rendo, A. G. Garcia, S. S. Santos, E. P. G. and Martinez, E. T. Diaz, M. J. Fernandez Alvarez, C. Magadan and Martin, V. Concepcion Lopez, C. Diaz Rodrigo, A. Rosat and Sanchez, L. E. Perez Cuadrado, M. Bailon Carrasco, C. Tinoco and Bhojwani, E. Choolani Sanchez, D. P. Ahmed, M. E. Dzhendov, T. Lindberg, F. Rutegard, M. Sundbom, M. Mickael, C. and Colucci, N. Schnider, A. Er, S. Kurnaz, E. Turkyilmaz, S. Turkyilmaz, A. Yildirim, R. Baki, B. E. Akkapulu, N. and Karahan, O. Damburaci, N. Hardwick, R. Safranek, P. and Sujendran, V Bennett, J. Afzal, Z. Shrotri, M. Chan, B. and Exarchou, K. Gilbert, T. Amalesh, T. Mukherjee, D. and Mukherjee, S. Wiggins, T. H. Kennedy, R. McCain, S. and Harris, A. Dobson, G. Davies, N. Wilson, I Mayo, D. and Bennett, D. Young, R. Manby, P. Blencowe, N. Schiller, M. Byrne, B. Mitton, D. Wong, V Elshaer, A. Cowen, M. Menon, V Tan, L. C. McLaughlin, E. Koshy, R. and Sharp, C. Brewer, H. Das, N. Cox, M. Al Khyatt, W. and Worku, D. Iqbal, R. Walls, L. McGregor, R. Fullarton, G. and Macdonald, A. MacKay, C. Craig, C. Dwerryhouse, S. and Hornby, S. Jaunoo, S. Wadley, M. Baker, C. Saad, M. and Kelly, M. Davies, A. Di Maggio, F. Mistry, P. Singhal, R. Tucker, O. Kapoulas, S. Powell-Brett, S. Davis, P. and Bromley, G. Watson, L. Verma, R. Ward, J. Shetty, V and Ball, C. Pursnani, K. Sarela, A. Ling, H. Sue Mehta, S. Hayden, J. To, N. Palser, T. Hunter, D. and Supramaniam, K. Butt, Z. Ahmed, A. Kumar, S. Chaudry, A. and Moussa, O. Kordzadeh, A. Patil, P. Noaman, I Willem, J. Bouras, G. Evans, R. Singh, M. Warrilow, H. and Ahmad, A. Tewari, N. Yanni, F. Couch, J. Theophilidou, E. Reilly, J. J. van Boxel, G. Akbari, K. Zanotti, D. and Sgromo, B. Sanders, G. Wheatley, T. Ariyarathenam, A. and Reece-Smith, A. Humphreys, L. Choh, C. Carter, N. and Knight, B. Pucher, P. Athanasiou, A. Tan, B. and Abdulrahman, M. Vickers, J. Akhtar, K. Chaparala, R. and Brown, R. Alasmar, M. M. A. Ackroyd, R. Patel, K. and Tamhankar, A. Wyman, A. Walker, R. Grace, B. Abbassi, N. and Slim, N. Ioannidi, L. Blackshaw, G. Havard, T. and Escofet, X. Powell, A. Owera, A. Rashid, F. Jambulingam, P. Padickakudi, J. Ben-Younes, H. McCormack, K. Makey, I. A. Karush, M. K. Seder, C. W. Liptay, M. J. and Chmielewski, G. Rosato, E. L. Berger, A. C. Zheng, R. and Okolo, E. Singh, A. Scott, C. D. Weyant, M. J. Mitchell, J. D. West Midlands Res Collaborative

Abstract

Background The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. Methods Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. Results Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). Conclusion Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on perioperative outcomes in the international multicentre Oesophago-Gastric Anastomosis Audit (OGAA). Analysis of 2232 oesophagectomies has shown that trainee involvement did not negatively impact perioperative outcomes.

Published
2021

41. Postoperative outcomes in oesophagectomy with trainee involvement

Author

Evans, R. P. (R. P. T.), Hodson, J. (J.), Kamarajah, S. K. (S. K.), Griffiths, E. A. (E. A.), Singh, P. (P.), Alderson, D. (D.), Bundred, J. (J.), Gossage, J. (J.), Jefferies, B. (B.), McKay, S. (S.), Mohamed, I. (I), Nepogodiev, D. (D.), Siaw-Acheampong, K. (K.), van Hillegersberg, R. (R.), Vohra, R. (R.), Wanigasooriya, K. (K.), Whitehouse, T. (T.), Gjata, A. (A.), Moreno, J. I. (J., I), Takeda, F. R. (F. R.), Kidane, B. (B.), Castro, R. G. (R. Guevara), Harustiak, T. (T.), Bekele, A. (A.), Kechagias, A. (A.), Gockel, I. (I), Kennedy, A. (A.), Da Roit, A. (A.), Bagajevas, A. (A.), Azagra, J. S. (J. S.), Mahendran, H. A. (H. A.), Mejia-Fernandez, L. (L.), Wijnhoven, B. P. (B. P. L.), El Kafsi, J. (J.), Sayyed, R. H. (R. H.), Sousa, M. (M.), Sampaio, A. S. (A. S.), Negoi, I. (I), Blanco, R. (R.), Wallner, B. (B.), Schneider, P. M. (P. M.), Hsu, P. K. (P. K.), Isik, A. (A.), Gananadha, S. (S.), Wills, V. (V), Devadas, M. (M.), Duong, C. (C.), Talbot, M. (M.), Hii, M. W. (M. W.), Jacobs, R. (R.), Andreollo, N. A. (N. A.), Johnston, B. (B.), Darling, G. (G.), Isaza-Restrepo, A. (A.), Rosero, G. (G.), Arias-Amezquita, F. (F.), Raptis, D. (D.), Gaedcke, J. (J.), Reim, D. (D.), Izbicki, J. (J.), Egberts, J. H. (J. H.), Dikinis, S. (S.), Kjaer, D. W. (D. W.), Larsen, M. H. (M. H.), Achiam, M. P. (M. P.), Saarnio, J. (J.), Theodorou, D. (D.), Liakakos, T. (T.), Korkolis, D. P. (D. P.), Robb, W. B. (W. B.), Collins, C. (C.), Murphy, T. (T.), Reynolds, J. (J.), Tonini, V. (V), Migliore, M. (M.), Bonavina, L. (L.), Valmasoni, M. (M.), Bardini, R. (R.), Weindelmayer, J. (J.), Terashima, M. (M.), White, R. E. (R. E.), Alghunaim, E. (E.), Elhadi, M. (M.), Leon-Takahashi, A. M. (A. M.), Medina-Franco, H. (H.), Lau, P. C. (P. C.), Okonta, K. E. (K. E.), Heisterkamp, J. (J.), Rosman, C. (C.), Beban, G. (G.), Babor, R. (R.), Gordon, A. (A.), Rossaak, J. I. (J., I), Pal, K. M. (K. M., I), Qureshi, A. U. (A. U.), Naqi, S. A. (S. A.), Syed, A. A. (A. A.), Barbosa, J. (J.), Vicente, C. S. (C. S.), Leite, J. (J.), Freire, J. (J.), Casaca, R. (R.), Costa, R. C. (R. C. T.), Scurtu, R. R. (R. R.), Mogoanta, S. S. (S. S.), Bolca, C. (C.), Constantinoiu, S. (S.), Sekhniaidze, D. (D.), So, J. B. (J. B. Y.), Gacvski, G. (G.), Loureiro, C. (C.), Pera, M. (M.), Bianchi, A. (A.), Gijon, M. M. (M. Moreno), Fernandez, J. M. (J. Martin), Carrera, M. S. (M. S. Trugeda), Vallve-Bernal, M. (M.), Pascual, M. A. (M. A. Citores), Elmahi, S. (S.), Halldestam, I. (I), Hedberg, J. (J.), Monig, S. (S.), Gutknecht, S. (S.), Tez, M. (M.), Guner, A. (A.), Tirnaksiz, T. B. (T. B.), Colak, E. (E.), Sevinc, B. (B.), Hindmarsh, A. (A.), Khan, I. (I), Khoo, D. (D.), Byrom, R. (R.), Gokhale, J. (J.), Wilkerson, P. (P.), Jain, P. (P.), Chan, D. (D.), Robertson, K. (K.), Iftikhar, S. (S.), Skipworth, R. (R.), Forshaw, M. (M.), Higgs, S. (S.), Nijjar, R. (R.), Viswanath, Y. K. (Y. K. S.), Turner, P. (P.), Dexter, S. (S.), Boddy, A. (A.), Allum, W. H. (W. H.), Oglesby, S. (S.), Cheong, E. (E.), Beardsmore, D. (D.), Maynard, N. (N.), Berrisford, R. (R.), Mercer, S. (S.), Puig, S. (S.), Melhado, R. (R.), Kelty, C. (C.), Underwood, T. (T.), Dawas, K. (K.), Lewis, W. (W.), Al-Bahrani, A. (A.), Bryce, G. (G.), Thomas, M. (M.), Arndt, A. T. (A. T.), Palazzo, F. (F.), Meguid, R. A. (R. A.), Fergusson, J. (J.), Beenen, E. (E.), Mosse, C. (C.), Salim, J. (J.), Cheah, S. (S.), Wright, T. (T.), Cerdeira, M. P. (M. P.), McQuillan, P. (P.), Richardson, M. (M.), Liem, H. (H.), Spillane, J. (J.), Yacob, M. (M.), Albadawi, F. (F.), Thorpe, T. (T.), Dingle, A. (A.), Cabalag, C. (C.), Loi, K. (K.), Fisher, O. M. (O. M.), Ward, S. (S.), Read, M. (M.), Johnson, M. (M.), Bassari, R. (R.), Bui, H. (H.), Cecconello, I. (I), Sallum, R. A. (R. A. A.), da Rocha, J. R. (J. R. M.), Lopes, L. R. (L. R.), Tercioti, V. J. (V., Jr.), Coelho, J. D. (J. D. S.), Ferrer, J. A. (J. A. P.), Buduhan, G. (G.), Tan, L. (L.), Srinathan, S. (S.), Shea, P. (P.), Yeung, J. (J.), Allison, F. (F.), Carroll, P. (P.), Vargas-Barato, F. (F.), Gonzalez, F. (F.), Ortega, J. (J.), Nino-Torres, L. (L.), Beltran-Garcia, T. C. (T. C.), Castilla, L. (L.), Pineda, M. (M.), Bastidas, A. (A.), Gomez-Mayorga, J. (J.), Cortes, N. (N.), Cetares, C. (C.), Caceres, S. (S.), Duarte, S. (S.), Pazdro, A. (A.), Snajdauf, M. (M.), Faltova, H. (H.), Sevcikova, M. (M.), Mortensen, P. B. (P. B.), Katballe, N. (N.), Ingemann, T. (T.), Morten, B. (B.), Kruhlikava, I. (I), Ainswort, A. P. (A. P.), Stilling, N. M. (N. M.), Eckardt, J. (J.), Holm, J. (J.), Thorsteinsson, M. (M.), Siemsen, M. (M.), Brandt, B. (B.), Nega, B. (B.), Teferra, E. (E.), Tizazu, A. (A.), Kauppila, J. S. (J. S.), Koivukangas, V. (V), Meriläinen, S. (S.), Gruetzmann, R. (R.), Krautz, C. (C.), Weber, G. (G.), Golcher, H. (H.), Emons, G. (G.), Azizian, A. (A.), Ebeling, M. (M.), Niebisch, S. (S.), Kreuser, N. (N.), Albanese, G. (G.), Hesse, J. (J.), Volovnik, L. (L.), Boecher, U. (U.), Reeh, M. (M.), Triantafyllou, S. 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(B.), De Manzoni, G. (G.), Giacopuzzi, S. (S.), La Mendola, R. (R.), De Pasqual, C. A. (C. A.), Tsubosa, Y. (Y.), Niihara, M. (M.), Irino, T. (T.), Makuuchi, R. (R.), Ishii, K. (K.), Mwachiro, M. (M.), Fekadu, A. (A.), Odera, A. (A.), Mwachiro, E. (E.), AlShehab, D. (D.), Ahmed, H. A. (H. A.), Shebani, A. O. (A. O.), Elhadi, A. (A.), Elnagar, F. A. (F. A.), Elnagar, H. F. (H. F.), Makkai-Popa, S. T. (S. T.), Wong, L. F. (L. F.), Yunrong, T. (T.), Thanninalai, S. (S.), Aik, H. C. (H. C.), Soon, P. W. (P. W.), Huei, T. J. (T. J.), Basave, H. N. (H. N. L.), Cortes-Gonzalez, R. (R.), Lagarde, S. M. (S. M.), van Lanschot, J. J. (J. J. B.), Cords, C. (C.), Jansen, W. A. (W. A.), Martijnse, I. (I), Matthijsen, R. (R.), Bouwense, S. (S.), Klarenbeek, B. (B.), Verstegen, M. (M.), van Workum, F. (F.), Ruurda, J. P. (J. P.), van der Veen, A. (A.), van den Berg, J. W. (J. W.), Evenett, N. (N.), Johnston, P. (P.), Patel, R. (R.), MacCormick, A. (A.), Young, M. (M.), Smith, B. (B.), Ekwunife, C. (C.), Memon, A. H. (A. H.), Shaikh, K. (K.), Wajid, A. (A.), Khalil, N. (N.), Haris, M. (M.), Mirza, Z. U. (Z. U.), Qudus, S. B. (S. B. A.), Sarwar, M. Z. (M. Z.), Shehzadi, A. (A.), Raza, A. (A.), Jhanzaib, M. H. (M. H.), Farmanali, J. (J.), Zakir, Z. (Z.), Shakeel, O. (O.), Nasir, I. (I), Khattak, S. (S.), Baig, M. (M.), Noor, M. A. (M. A.), Ahmed, H. H. (H. H.), Naeem, A. (A.), Pinho, A. C. (A. C.), da Silva, R. (R.), Bernardes, A. (A.), Campos, J. C. (J. C.), Matos, H. (H.), Braga, T. (T.), Monteiro, C. (C.), Ramos, P. (P.), Cabral, F. (F.), Gomes, M. P. (M. P.), Martins, P. C. (P. C.), Correia, A. M. (A. M.), Videira, J. F. (J. F.), Ciuce, C. (C.), Drasovean, R. (R.), Apostu, R. (R.), Paitici, S. (S.), Racu, A. E. (A. E.), Obleaga, C. V. (C., V), Beuran, M. (M.), Stoica, B. (B.), Ciubotaru, C. (C.), Negoita, V. (V), Cordos, I. (I), Birla, R. D. (R. D.), Predescu, D. (D.), Hoara, P. A. (P. A.), Tomsa, R. (R.), Shneider, V. (V), Agasiev, M. (M.), Ganjara, I. (I), Gunjic, D. (D.), Veselinovic, M. (M.), Babic, T. (T.), Chin, T. S. (T. S.), Shabbir, A. (A.), Kim, G. (G.), Crnjac, A. (A.), Samo, H. (H.), del Val, I. D. (I. Diez), Leturio, S. (S.), Ramon, J. M. (J. M.), Dal Cero, M. (M.), Rifa, S. (S.), Rico, M. (M.), Pomar, A. P. (A. Pagan), Corcoles, J. A. (J. A. Martinez), Miravalles, J. L. (J. L. Rodicio), Pais, S. A. (S. A.), Turienzo, S. A. (S. A.), Alvarez, L. S. (L. S.), Campos, P. V. (P., V), Rendo, A. G. (A. G.), Garcia, S. S. (S. S.), Santos, E. P. (E. P. G.), Martinez, E. T. (E. T.), Diaz, M. J. (M. J. Fernandez), Alvarez, C. M. (C. Magadan), Martin, V. C. (V. Concepcion), Lopez, C. D. (C. Diaz), Rodrigo, A. R. (A. Rosat), Sanchez, L. E. (L. E. Perez), Cuadrado, M. B. (M. Bailon), Carrasco, C. T. (C. Tinoco), Bhojwani, E. C. (E. Choolani), Sanchez, D. P. (D. P.), Ahmed, M. E. (M. E.), Dzhendov, T. (T.), Lindberg, F. (F.), Rutegard, M. (M.), Sundbom, M. (M.), Mickael, C. (C.), Colucci, N. (N.), Schnider, A. (A.), Er, S. (S.), Kurnaz, E. (E.), Turkyilmaz, S. (S.), Turkyilmaz, A. (A.), Yildirim, R. (R.), Baki, B. E. (B. E.), Akkapulu, N. (N.), Karahan, O. (O.), Damburaci, N. (N.), Hardwick, R. (R.), Safranek, P. (P.), Sujendran, V. (V), Bennett, J. (J.), Afzal, Z. (Z.), Shrotri, M. (M.), Chan, B. (B.), Exarchou, K. (K.), Gilbert, T. (T.), Amalesh, T. (T.), Mukherjee, D. (D.), Mukherjee, S. (S.), Wiggins, T. H. (T. H.), Kennedy, R. (R.), McCain, S. (S.), Harris, A. (A.), Dobson, G. (G.), Davies, N. (N.), Wilson, I. (I), Mayo, D. (D.), Bennett, D. (D.), Young, R. (R.), Manby, P. (P.), Blencowe, N. (N.), Schiller, M. (M.), Byrne, B. (B.), Mitton, D. (D.), Wong, V. (V), Elshaer, A. (A.), Cowen, M. (M.), Menon, V. (V), Tan, L. C. (L. C.), McLaughlin, E. (E.), Koshy, R. (R.), Sharp, C. (C.), Brewer, H. (H.), Das, N. (N.), Cox, M. (M.), Al Khyatt, W. (W.), Worku, D. (D.), Iqbal, R. (R.), Walls, L. (L.), McGregor, R. (R.), Fullarton, G. (G.), Macdonald, A. (A.), MacKay, C. (C.), Craig, C. (C.), Dwerryhouse, S. (S.), Hornby, S. (S.), Jaunoo, S. (S.), Wadley, M. (M.), Baker, C. (C.), Saad, M. (M.), Kelly, M. (M.), Davies, A. (A.), Di Maggio, F. (F.), Mistry, P. (P.), Singhal, R. (R.), Tucker, O. (O.), Kapoulas, S. (S.), Powell-Brett, S. (S.), Davis, P. (P.), Bromley, G. (G.), Watson, L. (L.), Verma, R. (R.), Ward, J. (J.), Shetty, V. (V), Ball, C. (C.), Pursnani, K. (K.), Sarela, A. (A.), Ling, H. S. (H. Sue), Mehta, S. (S.), Hayden, J. (J.), To, N. (N.), Palser, T. (T.), Hunter, D. (D.), Supramaniam, K. (K.), Butt, Z. (Z.), Ahmed, A. (A.), Kumar, S. (S.), Chaudry, A. (A.), Moussa, O. (O.), Kordzadeh, A. (A.), Patil, P. (P.), Noaman, I. (I), Willem, J. (J.), Bouras, G. (G.), Evans, R. (R.), Singh, M. (M.), Warrilow, H. (H.), Ahmad, A. (A.), Tewari, N. (N.), Yanni, F. (F.), Couch, J. (J.), Theophilidou, E. (E.), Reilly, J. J. (J. J.), van Boxel, G. (G.), Akbari, K. (K.), Zanotti, D. (D.), Sgromo, B. (B.), Sanders, G. (G.), Wheatley, T. (T.), Ariyarathenam, A. (A.), Reece-Smith, A. (A.), Humphreys, L. (L.), Choh, C. (C.), Carter, N. (N.), Knight, B. (B.), Pucher, P. (P.), Athanasiou, A. (A.), Tan, B. (B.), Abdulrahman, M. (M.), Vickers, J. (J.), Akhtar, K. (K.), Chaparala, R. (R.), Brown, R. (R.), Alasmar, M. M. (M. M. A.), Ackroyd, R. (R.), Patel, K. (K.), Tamhankar, A. (A.), Wyman, A. (A.), Walker, R. (R.), Grace, B. (B.), Abbassi, N. (N.), Slim, N. (N.), Ioannidi, L. (L.), Blackshaw, G. (G.), Havard, T. (T.), Escofet, X. (X.), Powell, A. (A.), Owera, A. (A.), Rashid, F. (F.), Jambulingam, P. (P.), Padickakudi, J. (J.), Ben-Younes, H. (H.), McCormack, K. (K.), Makey, I. A. (I. A.), Karush, M. K. (M. K.), Seder, C. W. (C. W.), Liptay, M. J. (M. J.), Chmielewski, G. (G.), Rosato, E. L. (E. L.), Berger, A. C. (A. C.), Zheng, R. (R.), Okolo, E. (E.), Singh, A. (A.), Scott, C. D. (C. D.), Weyant, M. J. (M. J.), and Mitchell, J. D. (J. D.)

Abstract

Background: The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. Methods: Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. Results: Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). Conclusions: Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery.

Published
2021

42. Prognostic value of patient-reported quality of life for survival in oesophagogastric cancer: Analysis from the population-based POCOP study

Author

Dutch Upper GI Canc Grp DUCG, van Kleef, J. J., Dijksterhuis, W. P. M., van den Boorn, H. G., Prins, M., Verhoeven, R. H. A., Gisbertz, S. S., Slingerland, M., Mohammad, N. Haj, Creemers, G-J, Neelis, K. J., Heisterkamp, J., Rosman, C., Ruurda, J. P., Kouwenhoven, E. A., van de Poll-Franse, L. V., van Oijen, M. G. H., Sprangers, M. A. G., van Laarhoven, H. W. M., Dutch Upper GI Canc Grp DUCG, van Kleef, J. J., Dijksterhuis, W. P. M., van den Boorn, H. G., Prins, M., Verhoeven, R. H. A., Gisbertz, S. S., Slingerland, M., Mohammad, N. Haj, Creemers, G-J, Neelis, K. J., Heisterkamp, J., Rosman, C., Ruurda, J. P., Kouwenhoven, E. A., van de Poll-Franse, L. V., van Oijen, M. G. H., Sprangers, M. A. G., and van Laarhoven, H. W. M.

Abstract

Background Accumulating evidence of trials demonstrates that patient-reported health-related quality of life (HRQoL) at diagnosis is prognostic for overall survival (OS) in oesophagogastric cancer. However, real-world data are lacking. Moreover, differences in disease stages and tumour-specific symptoms are usually not taken into consideration. The aim of this population-based study was to assess the prognostic value of HRQoL, including tumour-specific scales, on OS in patients with potentially curable and advanced oesophagogastric cancer. Methods Data were derived from the Netherlands Cancer Registry and the patient reported outcome registry (POCOP). Patients included in POCOP between 2016 and 2018 were stratified for potentially curable (cT1-4aNallM0) or advanced (cT4b or cM1) disease. HRQoL was measured with the EORTC QLQ-C30 and the tumour-specific OG25 module. Cox proportional hazards models assessed the impact of HRQoL, sociodemographic and clinical factors (including treatment) on OS. Results In total, 924 patients were included. Median OS was 38.9 months in potentially curable patients (n = 795) and 10.6 months in patients with advanced disease (n = 129). Global Health Status was independently associated with OS in potentially curable patients (HR 0.89, 99%CI 0.82-0.97), together with several other HRQoL items: appetite loss, dysphagia, eating restrictions, odynophagia, and body image. In advanced disease, the Summary Score was the strongest independent prognostic factor (HR 0.75, 99%CI 0.59-0.94), followed by fatigue, pain, insomnia and role functioning. Conclusion In a real-world setting, HRQoL was prognostic for OS in patients with potentially curable and advanced oesophagogastric cancer. Several HRQoL domains, including the Summary Score and several OG25 items, could be used to develop or update prognostic models.

Published
2021

43. Patient-reported outcomes after oesophagectomy in the multicentre LASER study

Author

Markar, S. R., Sounderajah, V., Johar, A., Zaninotto, G., Castoro, C., Lagergren, P., Elliott, J. A., Gisbertz, S. S., Mariette, C., Alfieri, R., Huddy, J., Pinto, E., Scarpa, M., Klevebro, F., Sunde, B., Murphy, C. F., Greene, C., Ravi, N., Piessen, G., Brenkman, H., Ruurda, J., van Hillegersberg, R., Lagarde, S. M., Wijnhoven, B. P., Pera, M., Roigg, J., Castro, S., Matthijsen, R., Findlay, J., Antonowicz, S., Maynard, N., McCormack, O., Ariyarathenam, A., Sanders, G., Cheong, E., Jaunoo, S., Allum, W., van Lanschot, J., Nilsson, M., Reynolds, J. V., van Berge Henegouwen, M. I., Hanna, G. B., Markar, S. R., Sounderajah, V., Johar, A., Zaninotto, G., Castoro, C., Lagergren, P., Elliott, J. A., Gisbertz, S. S., Mariette, C., Alfieri, R., Huddy, J., Pinto, E., Scarpa, M., Klevebro, F., Sunde, B., Murphy, C. F., Greene, C., Ravi, N., Piessen, G., Brenkman, H., Ruurda, J., van Hillegersberg, R., Lagarde, S. M., Wijnhoven, B. P., Pera, M., Roigg, J., Castro, S., Matthijsen, R., Findlay, J., Antonowicz, S., Maynard, N., McCormack, O., Ariyarathenam, A., Sanders, G., Cheong, E., Jaunoo, S., Allum, W., van Lanschot, J., Nilsson, M., Reynolds, J. V., van Berge Henegouwen, M. I., and Hanna, G. B.

Abstract

BACKGROUND: Data on the long-term symptom burden in patients surviving oesophageal cancer surgery are scarce. The aim of this study was to identify the most prevalent symptoms and their interactions with health-related quality of life. METHODS: This was a cross-sectional cohort study of patients who underwent oesophageal cancer surgery in 20 European centres between 2010 and 2016. Patients had to be disease-free for at least 1 year. They were asked to complete a 28-symptom questionnaire at a single time point, at least 1 year after surgery. Principal component analysis was used to assess for clustering and association of symptoms. Risk factors associated with the development of severe symptoms were identified by multivariable logistic regression models. RESULTS: Of 1081 invited patients, 876 (81.0 per cent) responded. Symptoms in the preceding 6 months associated with previous surgery were experienced by 586 patients (66.9 per cent). The most common severe symptoms included reduced energy or activity tolerance (30.7 per cent), feeling of early fullness after eating (30.0 per cent), tiredness (28.7 per cent), and heartburn/acid or bile regurgitation (19.6 per cent). Clustering analysis showed that symptoms clustered into six domains: lethargy, musculoskeletal pain, dumping, lower gastrointestinal symptoms, regurgitation/reflux, and swallowing/conduit problems; the latter two were the most closely associated. Surgical approach, neoadjuvant therapy, patient age, and sex were factors associated with severe symptoms. CONCLUSION: A long-term symptom burden is common after oesophageal cancer surgery.

Published
2021

44. Supervised exercise after oesophageal cancer surgery:the PERFECT multicentre randomized clinical trial

Author

van Vulpen, J. K., Hiensch, A. E., van Hillegersberg, R., Ruurda, J. P., Backx, F. J.G., Nieuwenhuijzen, G. A.P., Kouwenhoven, E. A., Groenendijk, R. P.R., van der Peet, D. L., Hazebroek, E. J., Rosman, C., Wijnhoven, B. P.L., van Berge Henegouwen, M. I., van Laarhoven, H. W.M., Siersema, P. D., May, A. M., van Vulpen, J. K., Hiensch, A. E., van Hillegersberg, R., Ruurda, J. P., Backx, F. J.G., Nieuwenhuijzen, G. A.P., Kouwenhoven, E. A., Groenendijk, R. P.R., van der Peet, D. L., Hazebroek, E. J., Rosman, C., Wijnhoven, B. P.L., van Berge Henegouwen, M. I., van Laarhoven, H. W.M., Siersema, P. D., and May, A. M.

Abstract

BACKGROUND: This study investigated whether a supervised exercise programme improves quality of life (QoL), fatigue and cardiorespiratory fitness in patients in the first year after oesophagectomy. METHODS: The multicentre PERFECT trial randomly assigned patients to an exercise intervention (EX) or usual care (UC) group. EX patients participated in a 12-week moderate- to high-intensity aerobic and resistance exercise programme supervised by a physiotherapist. Primary (global QoL, QoL summary score) and secondary (QoL subscales, fatigue and cardiorespiratory fitness) outcomes were assessed at baseline, 12 and 24 weeks and analysed as between-group differences using either linear mixed effects models or ANCOVA. RESULTS: A total of 120 patients (mean(s.d.) age 64(8) years) were included and randomized to EX (61 patients) or UC (59 patients). Patients in the EX group participated in 96 per cent (i.q.r. 92-100 per cent) of the exercise sessions and the relative exercise dose intensity was high (92 per cent). At 12 weeks, beneficial EX effects were found for QoL summary score (3.5, 95 per cent c.i. 0.2 to 6.8) and QoL role functioning (9.4, 95 per cent c.i. 1.3 to 17.5). Global QoL was not statistically significant different between groups (3.0, 95 per cent c.i. -2.2 to 8.2). Physical fatigue was lower in the EX group (-1.2, 95 per cent c.i. -2.6 to 0.1), albeit not significantly. There was statistically significant improvement in cardiorespiratory fitness following EX compared with UC (peak oxygen uptake (1.8 ml/min/kg, 95 per cent c.i. 0.6 to 3.0)). After 24 weeks, all EX effects were attenuated. CONCLUSIONS: A supervised exercise programme improved cardiorespiratory fitness and aspects of QoL. TRIAL REGISTRATION: Dutch Trial Register NTR 5045 (www.trialregister.nl/trial/4942).

Published
2021

45. Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus minimally invasive esophagectomy for resectable esophageal adenocarcinoma, a randomized controlled trial (ROBOT-2 trial)

Author

MS CGO, Cancer, Arts Assistenten CTC, Tagkalos, E., van der Sluis, P. C., Berlth, F., Poplawski, A., Hadzijusufovic, E., Lang, H., van Berge Henegouwen, M. I., Gisbertz, S. S., Müller-Stich, B. P., Ruurda, J. P., Schiesser, M., Schneider, P. M., van Hillegersberg, R., Grimminger, P. P., MS CGO, Cancer, Arts Assistenten CTC, Tagkalos, E., van der Sluis, P. C., Berlth, F., Poplawski, A., Hadzijusufovic, E., Lang, H., van Berge Henegouwen, M. I., Gisbertz, S. S., Müller-Stich, B. P., Ruurda, J. P., Schiesser, M., Schneider, P. M., van Hillegersberg, R., and Grimminger, P. P.

Published
2021

46. Patient-reported outcomes after oesophagectomy in the multicentre LASER study

Author

MS CGO, Cancer, Markar, S R, Sounderajah, V, Johar, A, Zaninotto, G, Castoro, C, Lagergren, P, Elliott, J A, Gisbertz, S S, Mariette, C, Alfieri, R, Huddy, J, Pinto, E, Scarpa, M, Klevebro, F, Sunde, B, Murphy, C F, Greene, C, Ravi, N, Piessen, G, Brenkman, H, Ruurda, J, van Hillegersberg, R, Lagarde, S M, Wijnhoven, B P, Pera, M, Roigg, J, Castro, S, Matthijsen, R, Findlay, J, Antonowicz, S, Maynard, N, McCormack, O, Ariyarathenam, A, Sanders, G, Cheong, E, Jaunoo, S, Allum, W, van Lanschot, J, Nilsson, M, Reynolds, J V, van Berge Henegouwen, M I, Hanna, G B, MS CGO, Cancer, Markar, S R, Sounderajah, V, Johar, A, Zaninotto, G, Castoro, C, Lagergren, P, Elliott, J A, Gisbertz, S S, Mariette, C, Alfieri, R, Huddy, J, Pinto, E, Scarpa, M, Klevebro, F, Sunde, B, Murphy, C F, Greene, C, Ravi, N, Piessen, G, Brenkman, H, Ruurda, J, van Hillegersberg, R, Lagarde, S M, Wijnhoven, B P, Pera, M, Roigg, J, Castro, S, Matthijsen, R, Findlay, J, Antonowicz, S, Maynard, N, McCormack, O, Ariyarathenam, A, Sanders, G, Cheong, E, Jaunoo, S, Allum, W, van Lanschot, J, Nilsson, M, Reynolds, J V, van Berge Henegouwen, M I, and Hanna, G B

Published
2021

47. Supervised exercise after oesophageal cancer surgery: the PERFECT multicentre randomized clinical trial

Author

Arts-assistenten Radiotherapie, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Cancer, MS CGO, RF&S Team 2 Medisch, Brain, Epidemiology & Health Economics, van Vulpen, J K, Hiensch, A E, van Hillegersberg, R, Ruurda, J P, Backx, F J G, Nieuwenhuijzen, G A P, Kouwenhoven, E A, Groenendijk, R P R, van der Peet, D L, Hazebroek, E J, Rosman, C, Wijnhoven, B P L, van Berge Henegouwen, Mark I, van Laarhoven, H W M, Siersema, PD, May, A M, Arts-assistenten Radiotherapie, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Cancer, MS CGO, RF&S Team 2 Medisch, Brain, Epidemiology & Health Economics, van Vulpen, J K, Hiensch, A E, van Hillegersberg, R, Ruurda, J P, Backx, F J G, Nieuwenhuijzen, G A P, Kouwenhoven, E A, Groenendijk, R P R, van der Peet, D L, Hazebroek, E J, Rosman, C, Wijnhoven, B P L, van Berge Henegouwen, Mark I, van Laarhoven, H W M, Siersema, PD, and May, A M

Published
2021

48. CTV-to-PTV margin assessment for esophageal cancer radiotherapy based on an accumulated dose analysis

Author

Fysica Radiotherapie Research, Cancer, MS CGO, Klinische Fysica RT, Onderzoek Beeld, MS Radiotherapie, Boekhoff, M R, Defize, I L, Borggreve, A S, van Hillegersberg, R, Kotte, A N T J, Lagendijk, J J W, van Lier, A L H M W, Ruurda, J P, Takahashi, N, Mook, S, Meijer, G J, Fysica Radiotherapie Research, Cancer, MS CGO, Klinische Fysica RT, Onderzoek Beeld, MS Radiotherapie, Boekhoff, M R, Defize, I L, Borggreve, A S, van Hillegersberg, R, Kotte, A N T J, Lagendijk, J J W, van Lier, A L H M W, Ruurda, J P, Takahashi, N, Mook, S, and Meijer, G J

Published
2021

49. Decrease of physical fitness during neoadjuvant chemoradiotherapy predicts the risk of pneumonia after esophagectomy

Author

Fysiotherapiewetenschap, MS CGO, Cancer, Afdeling Dietetiek, RF&S Team 1 Medisch, Brain, Bor, P, Kingma, B F, Kerst, A, Steenhagen, E, Ruurda, J P, van Hillegersberg, R, Valkenet, K, Veenhof, C, Fysiotherapiewetenschap, MS CGO, Cancer, Afdeling Dietetiek, RF&S Team 1 Medisch, Brain, Bor, P, Kingma, B F, Kerst, A, Steenhagen, E, Ruurda, J P, van Hillegersberg, R, Valkenet, K, and Veenhof, C

Published
2021

50. Salvage Robot-Assisted Minimally Invasive Esophagectomy (RAMIE) for T4b Esophageal Cancer After Definitive Chemoradiotherapy

Author

Fysica Radiotherapie Research, Cancer, MS CGO, Longziekten, MS Medische Oncologie, MS Radiotherapie, MS Mondziekten/Kaakchirurgie, Pathologie Pathologen staf, Defize, I L, van der Horst, S, Bülbul, M, Haj Mohammad, N, Mook, S, Meijer, G J, Brosens, L A A, Ruurda, J P, van Hillegersberg, R, Fysica Radiotherapie Research, Cancer, MS CGO, Longziekten, MS Medische Oncologie, MS Radiotherapie, MS Mondziekten/Kaakchirurgie, Pathologie Pathologen staf, Defize, I L, van der Horst, S, Bülbul, M, Haj Mohammad, N, Mook, S, Meijer, G J, Brosens, L A A, Ruurda, J P, and van Hillegersberg, R

Published
2021

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