594 results on '"Rowe, W"'
Search Results
2. Doping asymmetry of superconductivity coexisting with antiferromagnetism in spin fluctuation theory
- Author
-
Rowe, W., Eremin, I., Rømer, A., Andersen, B. M., and Hirschfeld, P. J.
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We generalize the theory of Cooper pairing by spin excitations in the metallic antiferromagnetic state to include situations with electron and/or hole pockets. We show that Cooper pairing arises from transverse spin waves and from gapped longitudinal spin fluctuations of comparable strength. However, each of these interactions, projected on a particular symmetry of the superconducting gap, acts primarily within one type of pocket. We find a nodeless $d_{x^2-y^2}$-wave state is supported primarily by the longitudinal fluctuations on the electron pockets, and both transverse and longitudinal fluctuations support nodeless odd-parity spin singlet $p-$wave symmetry on the hole pockets. Our results may be relevant to the asymmetry of the AF/SC coexistence state in the cuprate phase diagram, as well as for the "nodal gap" observed recently for strongly underdoped cuprates., Comment: 5 pages, 2 figures
- Published
- 2013
- Full Text
- View/download PDF
3. Spin excitations in layered antiferromagnetic metals and superconductors
- Author
-
Rowe, W., Knolle, J., Eremin, I., and Hirschfeld, P. J.
- Subjects
Condensed Matter - Superconductivity - Abstract
The proximity of antiferromagnetic order in high-temperature superconducting materials is considered a possible clue to the electronic excitations which form superconducting pairs. Here we study the transverse and longitudinal spin excitation spectrum in a one-band model in the pure spin density wave (SDW) state and in the coexistence state of SDW and the superconductivity. We start from a Stoner insulator and study the evolution of the spectrum with doping, including distinct situations with only hole pockets, with only electron pockets and with pockets of both types. In addition to the usual spin-wave modes, in the partially gapped cases we find significant weight of low-energy particle-hole excitations. We discuss the implications of our findings for neutron scattering experiments and for theories of Cooper-pairing in the metallic SDW state., Comment: (14 pages, 6 figures)
- Published
- 2012
- Full Text
- View/download PDF
4. Dominant leaders: Heroes or villains?
- Author
-
Tang, Jianyun, Crossan, Mary, and Rowe, W. Glenn
- Published
- 2019
- Full Text
- View/download PDF
5. Temperature regulates NF-κB dynamics and function through timing of A20 transcription
- Author
-
Harper, C. V., Woodcock, D. J., Lam, C., Garcia-Albornoz, M., Adamson, A., Ashall, L., Rowe, W., Downton, P., Schmidt, L., West, S., Spiller, D. G., Rand, D. A., and White, M. R. H.
- Published
- 2018
6. Creating Wealth in Organizations: The Role of Strategic Leadership
- Author
-
Rowe, W. Glenn
- Published
- 2001
7. Grinding Temperatures and Energy Partitioning
- Author
-
Rowe, W. B., Black, S. C. E., Mills, B., Morgan, M. N., and Qi, H. S.
- Published
- 1997
8. Related and Unrelated Diversification and Their Effect on Human Resource Management Controls
- Author
-
Rowe, W. Glenn and Wright, Patrick M.
- Published
- 1997
9. Efficacy of lumateperone in pooled short-term late-phase clinical trials for treatment of major depressive episodes associated with bipolar II disorder
- Author
-
Edwards, J., primary, Durgam, S., additional, Lakkis, H., additional, Kozauer, S.G., additional, Rowe, W., additional, Chen, C., additional, D’Souza, I., additional, and McIntyre, R.S., additional
- Published
- 2023
- Full Text
- View/download PDF
10. Rounding and stability in centreless grinding
- Author
-
Brian Rowe, W.
- Published
- 2014
- Full Text
- View/download PDF
11. Expatriate-deployment levels and subsidiary growth: A temporal analysis
- Author
-
Riaz, Suhaib, Glenn Rowe, W., and Beamish, Paul W.
- Published
- 2014
- Full Text
- View/download PDF
12. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2
- Author
-
Eales, O, Page, AJ, de Oliveira Martins, L, Wang, H, Bodinier, B, Haw, D, Jonnerby, J, Atchison, C, Robson, SC, Connor, TR, Loman, NJ, Golubchik, T, Nunez, RTM, Bonsall, D, Rambaut, A, Snell, LB, Livett, R, Ludden, C, Corden, S, Nastouli, E, Nebbia, G, Johnston, I, Lythgoe, K, Torok, ME, Goodfellow, IG, Prieto, JA, Saeed, K, Jackson, DK, Houlihan, C, Frampton, D, Hamilton, WL, Witney, AA, Bucca, G, Pope, CF, Moore, C, Thomson, EC, Harrison, EM, Smith, CP, Rogan, F, Beckwith, SM, Murray, A, Singleton, D, Eastick, K, Sheridan, LA, Randell, P, Jackson, LM, Ariani, CV, Gonçalves, S, Fairley, DJ, Loose, MW, Watkins, J, Moses, S, Nicholls, S, Bull, M, Amato, R, Smith, DL, Aanensen, DM, Barrett, JC, Aggarwal, D, Shepherd, JG, Curran, MD, Parmar, S, Parker, MD, Williams, C, Glaysher, S, Underwood, AP, Bashton, M, Pacchiarini, N, Loveson, KF, Byott, M, Carabelli, AM, Templeton, KE, de Silva, TI, Wang, D, Langford, CF, Sillitoe, J, Gunson, RN, Cottrell, S, O’Grady, J, Kwiatkowski, D, Lillie, PJ, Cortes, N, Moore, N, Thomas, C, Burns, PJ, Mahungu, TW, Liggett, S, Beckett, AH, Holden, MTG, Levett, LJ, Osman, H, Hassan-Ibrahim, MO, Simpson, DA, Chand, M, Gupta, RK, Darby, AC, Paterson, S, Pybus, OG, Volz, EM, de Angelis, D, Robertson, DL, Martincorena, I, Aigrain, L, Bassett, AR, Wong, N, Taha, Y, Erkiert, MJ, Chapman, MHS, Dewar, R, McHugh, MP, Mookerjee, S, Aplin, S, Harvey, M, Sass, T, Umpleby, H, Wheeler, H, McKenna, JP, Warne, B, Taylor, JF, Chaudhry, Y, Izuagbe, R, Jahun, AS, Young, GR, McMurray, C, McCann, CM, Nelson, A, Elliott, S, Lowe, H, Price, A, Crown, MR, Rey, S, Roy, S, Temperton, B, Shaaban, S, Hesketh, AR, Laing, KG, Monahan, IM, Heaney, J, Pelosi, E, Silviera, S, Wilson-Davies, E, Fryer, H, Adams, H, du Plessis, L, Johnson, R, Harvey, WT, Hughes, J, Orton, RJ, Spurgin, LG, Bourgeois, Y, Ruis, C, O’Toole, Á, Gourtovaia, M, Sanderson, T, Fraser, C, Edgeworth, J, Breuer, J, Michell, SL, Todd, JA, John, M, Buck, D, Gajee, K, Kay, GL, Peacock, SJ, Heyburn, D, Kitchman, K, McNally, A, Pritchard, DT, Dervisevic, S, Muir, P, Robinson, E, Vipond, BB, Ramadan, NA, Jeanes, C, Weldon, D, Catalan, J, Jones, N, da Silva Filipe, A, Fuchs, M, Miskelly, J, Jeffries, AR, Oliver, K, Park, NR, Ash, A, Koshy, C, Barrow, M, Buchan, SL, Mantzouratou, A, Clark, G, Holmes, CW, Campbell, S, Davis, T, Tan, NK, Brown, JR, Harris, KA, Kidd, SP, Grant, PR, Xu-McCrae, L, Cox, A, Madona, P, Pond, M, Randell, PA, Withell, KT, Graham, C, Denton-Smith, R, Swindells, E, Turnbull, R, Sloan, TJ, Bosworth, A, Hutchings, S, Pymont, HM, Casey, A, Ratcliffe, L, Jones, CR, Knight, BA, Haque, T, Hart, J, Irish-Tavares, D, Witele, E, Mower, C, Watson, LK, Collins, J, Eltringham, G, Crudgington, D, Macklin, B, Iturriza-Gomara, M, Lucaci, AO, McClure, PC, Carlile, M, Holmes, N, Storey, N, Rooke, S, Yebra, G, Craine, N, Perry, M, Alikhan, N - F, Bridgett, S, Cook, KF, Fearn, C, Goudarzi, S, Lyons, RA, Williams, T, Haldenby, ST, Durham, J, Leonard, S, Davies, RM, Batra, R, Blane, B, Spyer, MJ, Smith, P, Yavus, M, Williams, RJ, Mahanama, AIK, Samaraweera, B, Girgis, ST, Hansford, SE, Green, A, Beaver, C, Bellis, KL, Dorman, MJ, Kay, S, Prestwood, L, Rajatileka, S, Quick, J, Poplawski, R, Reynolds, N, Mack, A, Morriss, A, Whalley, T, Patel, B, Georgana, I, Hosmillo, M, Pinckert, ML, Stockton, J, Henderson, JH, Hollis, A, Stanley, W, Yew, WC, Myers, R, Thornton, A, Adams, A, Annett, T, Asad, H, Birchley, A, Coombes, J, Evans, JM, Fina, L, Gatica-Wilcox, B, Gilbert, L, Graham, L, Hey, J, Hilvers, E, Jones, S, Jones, H, Kumziene-Summerhayes, S, McKerr, C, Powell, J, Pugh, G, Taylor, S, Trotter, AJ, Williams, CA, Kermack, LM, Foulkes, BH, Gallis, M, Hornsby, HR, Louka, SF, Pohare, M, Wolverson, P, Zhang, P, MacIntyre-Cockett, G, Trebes, A, Moll, RJ, Ferguson, L, Goldstein, EJ, Maclean, A, Tomb, R, Starinskij, I, Thomson, L, Southgate, J, Kraemer, MUG, Raghwani, J, Zarebski, AE, Boyd, O, Geidelberg, L, Illingworth, CJ, Jackson, C, Pascall, D, Vattipally, S, Freeman, TM, Hsu, SN, Lindsey, BB, James, K, Lewis, K, Tonkin-Hill, G, Tovar-Corona, JM, Cox, MG, Abudahab, K, Menegazzo, M, MEng, BEWT, Yeats, CA, Mukaddas, A, Wright, DW, Colquhoun, R, Hill, V, Jackson, B, McCrone, JT, Medd, N, Scher, E, Keatley, J - P, Curran, T, Morgan, S, Maxwell, P, Smith, K, Eldirdiri, S, Kenyon, A, Holmes, AH, Price, JR, Wyatt, T, Mather, AE, Skvortsov, T, Hartley, JA, Guest, M, Kitchen, C, Merrick, I, Munn, R, Bertolusso, B, Lynch, J, Vernet, G, Kirk, S, Wastnedge, E, Stanley, R, Idle, G, Bradley, DT, Poyner, J, Mori, M, Jones, O, Wright, V, Brooks, E, Churcher, CM, Fragakis, M, Galai, K, Jermy, A, Judges, S, McManus, GM, Smith, KS, Westwick, E, Attwood, SW, Bolt, F, Davies, A, De Lacy, E, Downing, F, Edwards, S, Meadows, L, Jeremiah, S, Smith, N, Foulser, L, Charalampous, T, Patel, A, Berry, L, Boswell, T, Fleming, VM, Howson-Wells, HC, Joseph, A, Khakh, M, Lister, MM, Bird, PW, Fallon, K, Helmer, T, McMurray, CL, Odedra, M, Shaw, J, Tang, JW, Willford, NJ, Blakey, V, Raviprakash, V, Sheriff, N, Williams, L - A, Feltwell, T, Bedford, L, Cargill, JS, Hughes, W, Moore, J, Stonehouse, S, Atkinson, L, Lee, JCD, Shah, D, Alcolea-Medina, A, Ohemeng-Kumi, N, Ramble, J, Sehmi, J, Williams, R, Chatterton, W, Pusok, M, Everson, W, Castigador, A, Macnaughton, E, Bouzidi, KE, Lampejo, T, Sudhanva, M, Breen, C, Sluga, G, Ahmad, SSY, George, RP, Machin, NW, Binns, D, James, V, Blacow, R, Coupland, L, Smith, L, Barton, E, Padgett, D, Scott, G, Cross, A, Mirfenderesky, M, Greenaway, J, Cole, K, Clarke, P, Duckworth, N, Walsh, S, Bicknell, K, Impey, R, Wyllie, S, Hopes, R, Bishop, C, Chalker, V, Harrison, I, Gifford, L, Molnar, Z, Auckland, C, Evans, C, Johnson, K, Partridge, DG, Raza, M, Baker, P, Bonner, S, Essex, S, Murray, LJ, Lawton, AI, Burton-Fanning, S, Payne, BAI, Waugh, S, Gomes, AN, Kimuli, M, Murray, DR, Ashfield, P, Dobie, D, Ashford, F, Best, A, Crawford, L, Cumley, N, Mayhew, M, Megram, O, Mirza, J, Moles-Garcia, E, Percival, B, Driscoll, M, Ensell, L, Lowe, HL, Maftei, L, Mondani, M, Chaloner, NJ, Cogger, BJ, Easton, LJ, Huckson, H, Lewis, J, Lowdon, S, Malone, CS, Munemo, F, Mutingwende, M, Nicodemi, R, Podplomyk, O, Somassa, T, Beggs, A, Richter, A, Cormie, C, Dias, J, Forrest, S, Higginson, EE, Maes, M, Young, J, Davidson, RK, Jackson, KA, Turtle, L, Keeley, AJ, Ball, J, Byaruhanga, T, Chappell, JG, Dey, J, Hill, JD, Park, EJ, Fanaie, A, Hilson, RA, Yaze, G, Lo, S, Afifi, S, Beer, R, Maksimovic, J, McCluggage, K, Spellman, K, Bresner, C, Fuller, W, Marchbank, A, Workman, T, Shelest, E, Debebe, J, Sang, F, Zamudio, ME, Francois, S, Gutierrez, B, Vasylyeva, TI, Flaviani, F, Ragonnet-Cronin, M, Smollett, KL, Broos, A, Mair, D, Nichols, J, Nomikou, K, Tong, L, Tsatsani, I, O’Brien, PS, Rushton, S, Sanderson, R, Perkins, J, Cotton, S, Gallagher, A, Allara, E, Pearson, C, Bibby, D, Dabrera, G, Ellaby, N, Gallagher, E, Hubb, J, Lackenby, A, Lee, D, Manesis, N, Mbisa, T, Platt, S, Twohig, KA, Morgan, M, Aydin, A, Baker, DJ, Foster-Nyarko, E, Prosolek, SJ, Rudder, S, Baxter, C, Carvalho, SF, Lavin, D, Mariappan, A, Radulescu, C, Singh, A, Tang, M, Morcrette, H, Bayzid, N, Cotic, M, Balcazar, CE, Gallagher, MD, Maloney, D, Stanton, TD, Williamson, KA, Manley, R, Michelsen, ML, Sambles, CM, Studholme, DJ, Warwick-Dugdale, J, Eccles, R, Gemmell, M, Gregory, R, Hughes, M, Nelson, C, Rainbow, L, Vamos, EE, Webster, HJ, Whitehead, M, Wierzbicki, C, Angyal, A, Green, LR, Whiteley, M, Betteridge, E, Bronner, IF, Farr, BW, Goodwin, S, Lensing, SV, McCarthy, SA, Quail, MA, Rajan, D, Redshaw, NM, Scott, C, Shirley, L, Thurston, SAJ, Rowe, W, Gaskin, A, Le-Viet, T, Bonfield, J, Liddle, J, Whitwham, A, Ashby, D, Barclay, W, Taylor, G, Cooke, G, Ward, H, Darzi, A, Riley, S, Chadeau-Hyam, M, Donnelly, CA, Elliott, P, The COVID-19 Genomics UK (COG-UK) Consortium, Department of Health, Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC), Cancer Research UK, Commission of the European Communities, Wellcome Trust, National Institute for Health Research, and Imperial College Healthcare NHS Trust: Research Capability Funding (RCF)
- Subjects
Delta variant ,Science & Technology ,SARS-CoV-2 ,COVID-19 ,1103 Clinical Sciences ,C500 ,Microbiology ,Genetic diversity ,B900 ,Infectious Diseases ,England ,COVID-19 Genomics UK (COG-UK) Consortium ,1108 Medical Microbiology ,Mutation ,Humans ,Transmission advantage ,Life Sciences & Biomedicine ,Phylogeny ,0605 Microbiology - Abstract
Background Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the virus. However, with increasing levels of immunity through vaccination and natural infection the evolutionary pressure will switch towards immune escape. Genomic surveillance in regions of high immunity is crucial in detecting emerging variants that can more successfully navigate the immune landscape. Methods We present phylogenetic relationships and lineage dynamics within England (a country with high levels of immunity), as inferred from a random community sample of individuals who provided a self-administered throat and nose swab for rt-PCR testing as part of the REal-time Assessment of Community Transmission-1 (REACT-1) study. During round 14 (9 September–27 September 2021) and 15 (19 October–5 November 2021) lineages were determined for 1322 positive individuals, with 27.1% of those which reported their symptom status reporting no symptoms in the previous month. Results We identified 44 unique lineages, all of which were Delta or Delta sub-lineages, and found a reduction in their mutation rate over the study period. The proportion of the Delta sub-lineage AY.4.2 was increasing, with a reproduction number 15% (95% CI 8–23%) greater than the most prevalent lineage, AY.4. Further, AY.4.2 was less associated with the most predictive COVID-19 symptoms (p = 0.029) and had a reduced mutation rate (p = 0.050). Both AY.4.2 and AY.4 were found to be geographically clustered in September but this was no longer the case by late October/early November, with only the lineage AY.6 exhibiting clustering towards the South of England. Conclusions As SARS-CoV-2 moves towards endemicity and new variants emerge, genomic data obtained from random community samples can augment routine surveillance data without the potential biases introduced due to higher sampling rates of symptomatic individuals.
- Published
- 2022
13. The liability of closeness: Business relatedness and foreign subsidiary performance
- Author
-
Tang, Jianyun and Rowe, W. Glenn
- Published
- 2012
- Full Text
- View/download PDF
14. SARS-CoV-2 evolution during treatment of chronic infection
- Author
-
Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I. U., Roberts, D. J., Chandra, A., Temperton, N., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Gleadall, N., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Michael, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Estee Torok, M., Saeed, K., Prieto, J. A., Jackson, D. K., Hamilton, W. L., Snell, L. B., Moore, C., Harrison, E. M., Goncalves, S., Fairley, D. J., Loose, M. W., Watkins, J., Livett, R., Moses, S., Amato, R., Nicholls, S., Bull, M., Smith, D. L., Barrett, J., Aanensen, D. M., Curran, M. D., Parmar, S., Aggarwal, D., Shepherd, J. G., Parker, M. D., Glaysher, S., Bashton, M., Underwood, A. P., Pacchiarini, N., Loveson, K. F., Carabelli, A. M., Templeton, K. E., Langford, C. F., Sillitoe, J., de Silva, T. I., Wang, D., Kwiatkowski, D., Rambaut, A., O'Grady, J., Cottrell, S., Holden, M. T. G., Thomson, E. C., Osman, H., Andersson, M., Chauhan, A. J., Hassan-Ibrahim, M. O., Lawniczak, M., Alderton, A., Chand, M., Constantinidou, C., Unnikrishnan, M., Darby, A. C., Hiscox, J. A., Paterson, S., Martincorena, I., Robertson, D. L., Volz, E. M., Page, A. J., Pybus, O. G., Bassett, A. R., Ariani, C. V., Spencer Chapman, M. H., K. K., Li, Shah, R. N., Jesudason, N. G., Taha, Y., Mchugh, M. P., Dewar, R., Jahun, A. S., Mcmurray, C., Pandey, S., Mckenna, J. P., Nelson, A., Young, G. R., Mccann, C. M., Elliott, S., Lowe, H., Temperton, B., Roy, S., Price, A., Rey, S., Wyles, M., Rooke, S., Shaaban, S., de Cesare, M., Letchford, L., Silveira, S., Pelosi, E., Wilson-Davies, E., O'Toole, A., Hesketh, A. R., Stark, R., du Plessis, L., Ruis, C., Adams, H., Bourgeois, Y., Michell, S. L., Gramatopoulos, D., Edgeworth, J., Breuer, J., Todd, J. A., Fraser, C., Buck, D., John, M., Kay, G. L., Palmer, S., Peacock, S. J., Heyburn, D., Weldon, D., Robinson, E., Mcnally, A., Muir, P., Vipond, I. B., Boyes, J., Sivaprakasam, V., Salluja, T., Dervisevic, S., Meader, E. J., Park, N. R., Oliver, K., Jeffries, A. R., Ott, S., da Silva Filipe, A., Simpson, D. A., Williams, C., Masoli, J. A. H., Knight, B. A., Jones, C. R., Koshy, C., Ash, A., Casey, A., Bosworth, A., Ratcliffe, L., Xu-McCrae, L., Pymont, H. M., Hutchings, S., Berry, L., Jones, K., Halstead, F., Davis, T., Holmes, C., Iturriza-Gomara, M., Lucaci, A. O., Randell, P. A., Cox, A., Madona, P., Harris, K. A., Brown, J. R., Mahungu, T. W., Irish-Tavares, D., Haque, T., Hart, J., Witele, E., Fenton, M. L., Liggett, S., Graham, C., Swindells, E., Collins, J., Eltringham, G., Campbell, S., Mcclure, P. C., Clark, G., Sloan, T. J., Jones, C., Lynch, J., Warne, B., Leonard, S., Durham, J., Williams, T., Haldenby, S. T., Storey, N., Alikhan, N. -F., Holmes, N., Carlile, M., Perry, M., Craine, N., Lyons, R. A., Beckett, A. H., Goudarzi, S., Fearn, C., Cook, K., Dent, H., Paul, H., Davies, R., Blane, B., Girgis, S. T., Beale, M. A., Bellis, K. L., Dorman, M. J., Drury, E., Kane, L., Kay, S., Mcguigan, S., Nelson, R., Prestwood, L., Rajatileka, S., Batra, R., Williams, R. J., Kristiansen, M., Green, A., Justice, A., Mahanama, A. I. K., Samaraweera, B., Hadjirin, N. F., Quick, J., Poplawski, R., Kermack, L. M., Reynolds, N., Hall, G., Chaudhry, Y., Pinckert, M. L., Georgana, I., Moll, R. J., Thornton, A., Myers, R., Stockton, J., Williams, C. A., Yew, W. C., Trotter, A. J., Trebes, A., MacIntyre-Cockett, G., Birchley, A., Adams, A., Plimmer, A., Gatica-Wilcox, B., Mckerr, C., Hilvers, E., Jones, H., Asad, H., Coombes, J., Evans, J. M., Fina, L., Gilbert, L., Graham, L., Cronin, M., Kumziene-Summerhayes, S., Taylor, S., Jones, S., Groves, D. C., Zhang, P., Gallis, M., Louka, S. F., Starinskij, I., Jackson, C., Gourtovaia, M., Tonkin-Hill, G., Lewis, K., Tovar-Corona, J. M., James, K., Baxter, L., Alam, M. T., Orton, R. J., Hughes, J., Vattipally, S., Ragonnet-Cronin, M., Nascimento, F. F., Jorgensen, D., Boyd, O., Geidelberg, L., Zarebski, A. E., Raghwani, J., Kraemer, M. U. G., Southgate, J., Lindsey, B. B., Freeman, T. M., Keatley, J. -P., Singer, J. B., de Oliveira Martins, L., Yeats, C. A., Abudahab, K., Taylor, B. E. W., Menegazzo, M., Danesh, J., Hogsden, W., Eldirdiri, S., Kenyon, A., Mason, J., Robinson, T. I., Holmes, A., Hartley, J. A., Curran, T., Mather, A. E., Shankar, G., Jones, R., Howe, R., Morgan, S., Wastenge, E., Chapman, M. R., Mookerjee, S., Stanley, R., Smith, W., Peto, T., Eyre, D., Crook, D., Vernet, G., Kitchen, C., Gulliver, H., Merrick, I., Guest, M., Munn, R., Bradley, D. T., Wyatt, T., Beaver, C., Foulser, L., Churcher, C. M., Brooks, E., Smith, K. S., Galai, K., Mcmanus, G. M., Bolt, F., Coll, F., Meadows, L., Attwood, S. W., Davies, A., De Lacy, E., Downing, F., Edwards, S., Scarlett, G. P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Abnizova, I., Aigrain, L., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Betteridge, E., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Bonfield, J., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. C., Chapman, L., Chillingworth, T. -J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dougherty, M., Dove, A., Drummond, L., Dudek, M., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B., Fenton, M., Ferrero, M., Flack, N., Fordham, H., Forsythe, G., Francis, M., Fraser, A., Freeman, A., Galvin, A., Garcia-Casado, M., Gedny, A., Girgis, S., Glover, J., Goodwin, S., Gould, O., Gray, A., Gray, E., Griffiths, C., Gu, Y., Guerin, F., Hamilton, W., Hanks, H., Harrison, E., Harrott, A., Harry, E., Harvison, J., Heath, P., Hernandez-Koutoucheva, A., Hobbs, R., Holland, D., Holmes, S., Hornett, G., Hough, N., Huckle, L., Hughes-Hallet, L., Hunter, A., Inglis, S., Iqbal, S., Jackson, A., Jackson, D., Verdejo, C. J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Liddle, J., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Makunin, A., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mccarthy, S., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Puethe, C., Quail, M., Rajan, D., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Scott, C., Seekings, P., Shirley, L., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Jansen Van, P., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Whitwham, A., Widaa, S., Williams, M., Wilson, M., Wright, S., Farr, B. W., Quail, M. A., Thurston, S. A. J., Bronner, I. F., Redshaw, N. M., Lensing, S. V., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. J., Lackenby, A., Mbisa, T., Platt, S., Miah, S., Bibby, D., Manso, C., Hubb, J., Dabrera, G., Ramsay, M., Bradshaw, D., Schaefer, U., Groves, N., Gallagher, E., Lee, D., Williams, D., Ellaby, N., Hartman, H., Manesis, N., Patel, V., Ledesma, J., Twohig, K. A., Allara, E., Pearson, C., Cheng, J. K. J., Bridgewater, H. E., Frost, L. R., Taylor-Joyce, G., Brown, P. E., Tong, L., Broos, A., Mair, D., Nichols, J., Carmichael, S. N., Smollett, K. L., Nomikou, K., Aranday-Cortes, E., Johnson, N., Nickbakhsh, S., Vamos, E. E., Hughes, M., Rainbow, L., Eccles, R., Nelson, C., Whitehead, M., Gregory, R., Gemmell, M., Wierzbicki, C., Webster, H. J., Fisher, C. L., Signell, A. W., Betancor, G., Wilson, H. D., Nebbia, G., Flaviani, F., Cerda, A. C., Merrill, T. V., Wilson, R. E., Cotic, M., Bayzid, N., Thompson, T., Acheson, E., Rushton, S., O'Brien, S., Baker, D. J., Rudder, S., Aydin, A., Sang, F., Debebe, J., Francois, S., Vasylyeva, T. I., Zamudio, M. E., Gutierrez, B., Marchbank, A., Maksimovic, J., Spellman, K., Mccluggage, K., Morgan, M., Beer, R., Afifi, S., Workman, T., Fuller, W., Bresner, C., Angyal, A., Green, L. R., Parsons, P. J., Tucker, R. M., Brown, R., Whiteley, M., Rowe, W., Siveroni, I., Le-Viet, T., Gaskin, A., Johnson, R., Sharrocks, K., Blane, E., Modis, Y., Leigh, K. E., Briggs, J. A. G., van Gils, M. J., Smith, K. G. C., Bradley, J. R., Doffinger, R., Ceron-Gutierrez, L., Barcenas-Morales, G., Pollock, D. D., Goldstein, R. A., Smielewska, A., Skittrall, J. P., Gouliouris, T., Goodfellow, I. G., Gkrania-Klotsas, E., Illingworth, C. J. R., Mccoy, L. E., Gupta, R. K., Medical Microbiology and Infection Prevention, AII - Infectious diseases, Collier, Dami A [0000-0001-5446-4423], Jahun, Aminu [0000-0002-4585-1701], Temperton, Nigel [0000-0002-7978-3815], Modis, Yorgo [0000-0002-6084-0429], Briggs, John AG [0000-0003-3990-6910], Goldstein, Richard A [0000-0001-5148-4672], Skittrall, Jordan P [0000-0002-8228-3758], Gkrania-Klotsas, Effrossyni [0000-0002-0930-8330], McCoy, Laura E [0000-0001-9503-7946], Gupta, Ravindra K [0000-0001-9751-1808], and Apollo - University of Cambridge Repository
- Subjects
0301 basic medicine ,Male ,Time Factors ,viruses ,Passive ,Antibodies, Viral ,CITIID-NIHR BioResource COVID-19 Collaboration ,2.1 Biological and endogenous factors ,Viral ,Aetiology ,Neutralizing ,Lung ,Phylogeny ,neutralising antibodies ,Infectivity ,education.field_of_study ,Genome ,Multidisciplinary ,Alanine ,biology ,High-Throughput Nucleotide Sequencing ,Viral Load ,Spike Glycoprotein ,Virus Shedding ,Adenosine Monophosphate ,Aged ,Antibodies, Neutralizing ,COVID-19 ,Chronic Disease ,Genome, Viral ,Humans ,Immune Evasion ,Immune Tolerance ,Immunization, Passive ,Immunosuppression Therapy ,Mutagenesis ,Mutant Proteins ,Mutation ,SARS-CoV-2 ,Spike Glycoprotein, Coronavirus ,Evolution, Molecular ,Infectious Diseases ,Pneumonia & Influenza ,Antibody ,Infection ,Viral load ,Biotechnology ,Evolution ,General Science & Technology ,antibody escape, Convalescent plasma ,030106 microbiology ,Population ,evasion ,Antibodies ,Virus ,Article ,Vaccine Related ,resistance ,03 medical and health sciences ,Immune system ,COVID-19 Genomics UK (COG-UK) Consortium ,Biodefense ,Genetics ,Viral shedding ,education ,COVID-19 Serotherapy ,QR355 ,Prevention ,Wild type ,Molecular ,Pneumonia ,Virology ,COVID-19 Drug Treatment ,Coronavirus ,Emerging Infectious Diseases ,Good Health and Well Being ,030104 developmental biology ,biology.protein ,Immunization ,immune suppression ,mutation - Abstract
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma, by generating whole-genome ultra-deep sequences for 23 time points that span 101 days and using in vitro techniques to characterize the mutations revealed by sequencing. There was little change in the overall structure of the viral population after two courses of remdesivir during the first 57 days. However, after convalescent plasma therapy, we observed large, dynamic shifts in the viral population, with the emergence of a dominant viral strain that contained a substitution (D796H) in the S2 subunit and a deletion (ΔH69/ΔV70) in the S1 N-terminal domain of the spike protein. As passively transferred serum antibodies diminished, viruses with the escape genotype were reduced in frequency, before returning during a final, unsuccessful course of convalescent plasma treatment. In vitro, the spike double mutant bearing both ΔH69/ΔV70 and D796H conferred modestly decreased sensitivity to convalescent plasma, while maintaining infectivity levels that were similar to the wild-type virus.The spike substitution mutant D796H appeared to be the main contributor to the decreased susceptibility to neutralizing antibodies, but this mutation resulted in an infectivity defect. The spike deletion mutant ΔH69/ΔV70 had a twofold higher level of infectivity than wild-type SARS-CoV-2, possibly compensating for the reduced infectivity of the D796H mutation. These data reveal strong selection on SARS-CoV-2 during convalescent plasma therapy, which is associated with the emergence of viral variants that show evidence of reduced susceptibility to neutralizing antibodies in immunosuppressed individuals.
- Published
- 2021
15. Modelling Employment Durations of NHL Head Coaches: Turnover and Post-Succession Performance
- Author
-
Audas, Rick, Goddard, John, and Rowe, W. Glenn
- Published
- 2006
- Full Text
- View/download PDF
16. Genomic reconstruction of the SARS-CoV-2 epidemic in England
- Author
-
Vöhringer, HS, Sanderson, T, Sinnott, M, De Maio, N, Nguyen, T, Goater, R, Schwach, F, Harrison, I, Hellewell, J, Ariani, CV, Gonçalves, S, Jackson, DK, Johnston, I, Jung, AW, Saint, C, Sillitoe, J, Suciu, M, Goldman, N, Panovska-Griffiths, J, Abnizova, I, Aigrain, L, Alderton, A, Ali, M, Allen, L, Amato, R, Anderson, R, Ariani, C, Austin-Guest, S, Bala, S, Barrett, J, Bassett, A, Battleday, K, Beal, J, Beale, M, Beaver, C, Bellany, S, Bellerby, T, Bellis, K, Berger, D, Berriman, M, Betteridge, E, Bevan, P, Binley, S, Bishop, J, Blackburn, K, Bonfield, J, Boughton, N, Bowker, S, Brendler-Spaeth, T, Bronner, I, Brooklyn, T, Buddenborg, SK, Bush, R, Caetano, C, Cagan, A, Carter, N, Cartwright, J, Monteiro, TC, Chapman, L, Chillingworth, T-J, Clapham, P, Clark, R, Clarke, A, Clarke, C, Cole, D, Cook, E, Coppola, M, Cornell, L, Cornwell, C, Corton, C, Crackett, A, Cranage, A, Craven, H, Craw, S, Crawford, M, Cutts, T, Dabrowska, M, Davies, M, Davies, R, Dawson, J, Day, C, Densem, A, Dibling, T, Dockree, C, Dodd, D, Dogga, S, Dorman, M, Dougan, G, Dougherty, M, Dove, A, Drummond, L, Drury, E, Dudek, M, Durham, J, Durrant, L, Easthope, E, Eckert, S, Ellis, P, Farr, B, Fenton, M, Ferrero, M, Flack, N, Fordham, H, Forsythe, G, Foulser, L, Francis, M, Fraser, A, Freeman, A, Galvin, A, Garcia-Casado, M, Gedny, A, Girgis, S, Glover, J, Goncalves, S, Goodwin, S, Gould, O, Gourtovaia, M, Gray, A, Gray, E, Griffiths, C, Gu, Y, Guerin, F, Hamilton, W, Hanks, H, Harrison, E, Harrott, A, Harry, E, Harvison, J, Heath, P, Hernandez-Koutoucheva, A, Hobbs, R, Holland, D, Holmes, S, Hornett, G, Hough, N, Huckle, L, Hughes-Hallet, L, Hunter, A, Inglis, S, Iqbal, S, Jackson, A, Jackson, D, James, K, Jamrozy, D, Verdejo, CJ, Jones, M, Kallepally, K, Kane, L, Kay, K, Kay, S, Keatley, J, Keith, A, King, A, Kitchin, L, Kleanthous, M, Klimekova, M, Korlevic, P, Krasheninnkova, K, Lane, G, Langford, C, Laverack, A, Law, K, Lawniczak, M, Lensing, S, Leonard, S, Letchford, L, Lewis, K, Lewis-Wade, A, Liddle, J, Lin, Q, Lindsay, S, Linsdell, S, Livett, R, Lo, S, Long, R, Lovell, J, Ludden, C, Mack, J, Maddison, M, Makunin, A, Mamun, I, Mansfield, J, Marriott, N, Martin, M, Mayho, M, McCarthy, S, McClintock, J, McGuigan, S, McHugh, S, McMinn, L, Meadows, C, Mobley, E, Moll, R, Morra, M, Morrow, L, Murie, K, Nash, S, Nathwani, C, Naydenova, P, Neaverson, A, Nelson, R, Nerou, E, Nicholson, J, Nimz, T, Noell, GG, O’Meara, S, Ohan, V, Oliver, K, Olney, C, Ormond, D, Oszlanczi, A, Palmer, S, Pang, YF, Pardubska, B, Park, N, Parmar, A, Patel, G, Patel, M, Payne, M, Peacock, S, Petersen, A, Plowman, D, Preston, T, Prestwood, L, Puethe, C, Quail, M, Rajan, D, Rajatileka, S, Rance, R, Rawlings, S, Redshaw, N, Reynolds, J, Reynolds, M, Rice, S, Richardson, M, Roberts, C, Robinson, K, Robinson, M, Robinson, D, Rogers, H, Rojo, EM, Roopra, D, Rose, M, Rudd, L, Sadri, R, Salmon, N, Saul, D, Scott, C, Seekings, P, Shirley, L, Simms, A, Sivadasan, S, Siwek, B, Sizer, D, Skeldon, K, Skelton, J, Slater-Tunstill, J, Sloper, L, Smerdon, N, Smith, C, Smith, J, Smith, K, Smith, M, Smith, S, Smith, T, Sneade, L, Soria, CD, Sousa, C, Souster, E, Sparkes, A, Spencer-Chapman, M, Squares, J, Stanley, R, Steed, C, Stickland, T, Still, I, Stratton, MR, Strickland, M, Swann, A, Swiatkowska, A, Sycamore, N, Swift, E, Symons, E, Szluha, S, Taluy, E, Tao, N, Taylor, K, Taylor, S, Thompson, S, Thompson, M, Thomson, M, Thomson, N, Thurston, S, Tonkin-Hill, G, Toombs, D, Topping, B, Tovar-Corona, J, Ungureanu, D, Uphill, J, Urbanova, J, Van Vuuren, PJ, Vancollie, V, Voak, P, Walker, D, Walker, M, Waller, M, Ward, G, Weatherhogg, C, Webb, N, Weldon, D, Wells, A, Wells, E, Westwood, L, Whipp, T, Whiteley, T, Whitton, G, Whitwham, A, Widaa, S, Williams, M, Wilson, M, Wright, S, Robson, SC, Connor, TR, Loman, NJ, Golubchik, T, Martinez Nunez, RT, Bonsall, D, Rambaut, A, Snell, LB, Corden, S, Nastouli, E, Nebbia, G, Lythgoe, K, Torok, ME, Goodfellow, IG, Prieto, JA, Saeed, K, Houlihan, C, Frampton, D, Hamilton, WL, Witney, AA, Bucca, G, Pope, CF, Moore, C, Thomson, EC, Harrison, EM, Smith, CP, Rogan, F, Beckwith, SM, Murray, A, Singleton, D, Eastick, K, Sheridan, LA, Randell, P, Jackson, LM, Fairley, DJ, Loose, MW, Watkins, J, Moses, S, Nicholls, S, Bull, M, Smith, DL, Aanensen, DM, Aggarwal, D, Shepherd, JG, Curran, MD, Parmar, S, Parker, MD, Williams, C, Glaysher, S, Underwood, AP, Bashton, M, Pacchiarini, N, Loveson, KF, Byott, M, Carabelli, AM, Templeton, KE, de Silva, TI, Wang, D, Langford, CF, Gunson, RN, Cottrell, S, O’Grady, J, Kwiatkowski, D, Lillie, PJ, Cortes, N, Moore, N, Thomas, C, Burns, PJ, Mahungu, TW, Liggett, S, Beckett, AH, Holden, MTG, Levett, LJ, Osman, H, Hassan-Ibrahim, MO, Simpson, DA, Chand, M, Gupta, RK, Darby, AC, Paterson, S, Pybus, OG, Volz, EM, de Angelis, D, Robertson, DL, Page, AJ, Bassett, AR, Wong, N, Taha, Y, Erkiert, MJ, Spencer Chapman, MH, Dewar, R, McHugh, MP, Mookerjee, S, Aplin, S, Harvey, M, Sass, T, Umpleby, H, Wheeler, H, McKenna, JP, Warne, B, Taylor, JF, Chaudhry, Y, Izuagbe, R, Jahun, AS, Young, GR, McMurray, C, McCann, CM, Nelson, A, Elliott, S, Lowe, H, Price, A, Crown, MR, Rey, S, Roy, S, Temperton, B, Shaaban, S, Hesketh, AR, Laing, KG, Monahan, IM, Heaney, J, Pelosi, E, Silviera, S, Wilson-Davies, E, Fryer, H, Adams, H, du Plessis, L, Johnson, R, Harvey, WT, Hughes, J, Orton, RJ, Spurgin, LG, Bourgeois, Y, Ruis, C, O’Toole, Á, Fraser, C, Edgeworth, J, Breuer, J, Michell, SL, Todd, JA, John, M, Buck, D, Gajee, K, Kay, GL, Peacock, SJ, Heyburn, D, Kitchman, K, McNally, A, Pritchard, DT, Dervisevic, S, Muir, P, Robinson, E, Vipond, BB, Ramadan, NA, Jeanes, C, Catalan, J, Jones, N, da Silva Filipe, A, Fuchs, M, Miskelly, J, Jeffries, AR, Park, NR, Ash, A, Koshy, C, Barrow, M, Buchan, SL, Mantzouratou, A, Clark, G, Holmes, CW, Campbell, S, Davis, T, Tan, NK, Brown, JR, Harris, KA, Kidd, SP, Grant, PR, Xu-McCrae, L, Cox, A, Madona, P, Pond, M, Randell, PA, Withell, KT, Graham, C, Denton-Smith, R, Swindells, E, Turnbull, R, Sloan, TJ, Bosworth, A, Hutchings, S, Pymont, HM, Casey, A, Ratcliffe, L, Jones, CR, Knight, BA, Haque, T, Hart, J, Irish-Tavares, D, Witele, E, Mower, C, Watson, LK, Collins, J, Eltringham, G, Crudgington, D, Macklin, B, Iturriza-Gomara, M, Lucaci, AO, McClure, PC, Carlile, M, Holmes, N, Storey, N, Rooke, S, Yebra, G, Craine, N, Perry, M, Alikhan, N-F, Bridgett, S, Cook, KF, Fearn, C, Goudarzi, S, Lyons, RA, Williams, T, Haldenby, ST, Davies, RM, Batra, R, Blane, B, Spyer, MJ, Smith, P, Yavus, M, Williams, RJ, Mahanama, AIK, Samaraweera, B, Girgis, ST, Hansford, SE, Green, A, Bellis, KL, Dorman, MJ, Quick, J, Poplawski, R, Reynolds, N, Mack, A, Morriss, A, Whalley, T, Patel, B, Georgana, I, Hosmillo, M, Pinckert, ML, Stockton, J, Henderson, JH, Hollis, A, Stanley, W, Yew, WC, Myers, R, Thornton, A, Adams, A, Annett, T, Asad, H, Birchley, A, Coombes, J, Evans, JM, Fina, L, Gatica-Wilcox, B, Gilbert, L, Graham, L, Hey, J, Hilvers, E, Jones, S, Jones, H, Kumziene-Summerhayes, S, McKerr, C, Powell, J, Pugh, G, Trotter, AJ, Williams, CA, Kermack, LM, Foulkes, BH, Gallis, M, Hornsby, HR, Louka, SF, Pohare, M, Wolverson, P, Zhang, P, MacIntyre-Cockett, G, Trebes, A, Moll, RJ, Ferguson, L, Goldstein, EJ, Maclean, A, Tomb, R, Starinskij, I, Thomson, L, Southgate, J, Kraemer, MUG, Raghwani, J, Zarebski, AE, Boyd, O, Geidelberg, L, Illingworth, CJ, Jackson, C, Pascall, D, Vattipally, S, Freeman, TM, Hsu, SN, Lindsey, BB, Tovar-Corona, JM, Cox, M, Abudahab, K, Menegazzo, M, Taylor, BEW, Yeats, CA, Mukaddas, A, Wright, DW, de Oliveira Martins, L, Colquhoun, R, Hill, V, Jackson, B, McCrone, JT, Medd, N, Scher, E, Keatley, J-P, Curran, T, Morgan, S, Maxwell, P, Eldirdiri, S, Kenyon, A, Holmes, AH, Price, JR, Wyatt, T, Mather, AE, Skvortsov, T, Hartley, JA, Guest, M, Kitchen, C, Merrick, I, Munn, R, Bertolusso, B, Lynch, J, Vernet, G, Kirk, S, Wastnedge, E, Idle, G, Bradley, DT, Poyner, J, Mori, M, Jones, O, Wright, V, Brooks, E, Churcher, CM, Fragakis, M, Galai, K, Jermy, A, Judges, S, McManus, GM, Smith, KS, Westwick, E, Attwood, SW, Bolt, F, Davies, A, De Lacy, E, Downing, F, Edwards, S, Meadows, L, Jeremiah, S, Smith, N, Charalampous, T, Patel, A, Berry, L, Boswell, T, Fleming, VM, Howson-Wells, HC, Joseph, A, Khakh, M, Lister, MM, Bird, PW, Fallon, K, Helmer, T, McMurray, CL, Odedra, M, Shaw, J, Tang, JW, Willford, NJ, Blakey, V, Raviprakash, V, Sheriff, N, Williams, L-A, Feltwell, T, Bedford, L, Cargill, JS, Hughes, W, Moore, J, Stonehouse, S, Atkinson, L, Lee, JCD, Shah, D, Alcolea, A, Ohemeng-Kumi, N, Ramble, J, Sehmi, J, Williams, R, Chatterton, W, Pusok, M, Everson, W, Castigador, A, Macnaughton, E, El Bouzidi, K, Lampejo, T, Sudhanva, M, Breen, C, Sluga, G, Ahmad, SSY, George, RP, Machin, NW, Binns, D, James, V, Blacow, R, Coupland, L, Smith, L, Barton, E, Padgett, D, Scott, G, Cross, A, Mirfenderesky, M, Greenaway, J, Cole, K, Clarke, P, Duckworth, N, Walsh, S, Bicknell, K, Impey, R, Wyllie, S, Hopes, R, Bishop, C, Chalker, V, Gifford, L, Molnar, Z, Auckland, C, Evans, C, Johnson, K, Partridge, DG, Raza, M, Baker, P, Bonner, S, Essex, S, Murray, LJ, Lawton, AI, Burton-Fanning, S, Payne, BAI, Waugh, S, Gomes, AN, Kimuli, M, Murray, DR, Ashfield, P, Dobie, D, Ashford, F, Best, A, Crawford, L, Cumley, N, Mayhew, M, Megram, O, Mirza, J, Moles-Garcia, E, Percival, B, Ensell, L, Lowe, HL, Maftei, L, Mondani, M, Chaloner, NJ, Cogger, BJ, Easton, LJ, Huckson, H, Lewis, J, Lowdon, S, Malone, CS, Munemo, F, Mutingwende, M, Nicodemi, R, Podplomyk, O, Somassa, T, Beggs, A, Richter, A, Cormie, C, Dias, J, Forrest, S, Higginson, EE, Maes, M, Young, J, Davidson, RK, Jackson, KA, Turtle, L, Keeley, AJ, Ball, J, Byaruhanga, T, Chappell, JG, Dey, J, Hill, JD, Park, EJ, Fanaie, A, Hilson, RA, Yaze, G, Afifi, S, Beer, R, Maksimovic, J, Masters, KM, Spellman, K, Bresner, C, Fuller, W, Marchbank, A, Workman, T, Shelest, E, Debebe, J, Sang, F, Zamudio, ME, Francois, S, Gutierrez, B, Vasylyeva, TI, Flaviani, F, Ragonnet-Cronin, M, Smollett, KL, Broos, A, Mair, D, Nichols, J, Nomikou, K, Tong, L, Tsatsani, I, O’Brien, S, Rushton, S, Sanderson, R, Perkins, J, Cotton, S, Gallagher, A, Allara, E, Pearson, C, Bibby, D, Dabrera, G, Ellaby, N, Gallagher, E, Hubb, J, Lackenby, A, Lee, D, Manesis, N, Mbisa, T, Platt, S, Twohig, KA, Morgan, M, Aydin, A, Baker, DJ, Foster-Nyarko, E, Prosolek, SJ, Rudder, S, Baxter, C, Carvalho, SF, Lavin, D, Mariappan, A, Radulescu, C, Singh, A, Tang, M, Morcrette, H, Bayzid, N, Cotic, M, Balcazar, CE, Gallagher, MD, Maloney, D, Stanton, TD, Williamson, KA, Manley, R, Michelsen, ML, Sambles, CM, Studholme, DJ, Warwick-Dugdale, J, Eccles, R, Gemmell, M, Gregory, R, Hughes, M, Nelson, C, Rainbow, L, Vamos, EE, Webster, HJ, Whitehead, M, Wierzbicki, C, Angyal, A, Green, LR, Whiteley, M, Bronner, IF, Farr, BW, Lensing, SV, McCarthy, SA, Quail, MA, Redshaw, NM, Thurston, SAJ, Rowe, W, Gaskin, A, Le-Viet, T, Birney, E, Volz, E, Funk, S, Martincorena, I, Barrett, JC, and Gerstung, M
- Abstract
The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021.
- Published
- 2021
17. Conclusions and reflections
- Author
-
Piggot-Irvine, E, Ferkins, L, Rowe, W, Sankaran, S, Piggot-Irvine, E, Ferkins, L, Rowe, W, and Sankaran, S
- Abstract
This book will be a valuable resource for: action researchers throughout the world; postgraduate research students, academics and libraries; evaluators; and anyone in communities who wishes to know how to create sustainable change.
- Published
- 2021
18. Observations on Black Humor in Gogol' and Nabokov
- Author
-
Rowe, W. Woodin
- Published
- 1974
- Full Text
- View/download PDF
19. A Study of the Geometrical Drawings from the New Hebrides
- Author
-
Rowe, W. Page
- Published
- 1936
- Full Text
- View/download PDF
20. Identification of L-Methionine-S-Sulfoximine as the Convulsant Isomer of Methionine Sulfoximine
- Author
-
Rowe, W. Bruce and Meister, Alton
- Published
- 1970
21. Rescue of the Defective Genome of Moloney Sarcoma Virus from a Noninfectious Hamster Tumor and the Production of Pseudotype Sarcoma Viruses with Various Murine Leukemia Viruses
- Author
-
Huebner, R. J., Hartley, J. W., Rowe, W. P., Lane, W. T., and Capps, W. I.
- Published
- 1966
22. Specific Adenovirus Complement-Fixing Antigens in Virus-Free Hamster and Rat Tumors
- Author
-
Huebner, R. J., Rowe, W. P., Turner, H. C., and Lane, W. T.
- Published
- 1963
23. Studies of Small DNA Viruses Found in Various Adenovirus Preparations: Physical, Biological, and Immunological Characteristics
- Author
-
Hoggan, M. David, Blacklow, Neil R., and Rowe, W. P.
- Published
- 1966
24. The Burden of Tax Exemption of Government Bonds
- Author
-
Rowe, W. H.
- Published
- 1926
25. Dostoevskian Patterned Antinomy and Its Function in Crime and Punishment
- Author
-
Rowe, W. Woodin
- Published
- 1972
- Full Text
- View/download PDF
26. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
- Author
-
Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., Kemp, S. A., Bassi, J., Pinto, D., Silacci-Fregni, C., Bianchi, S., Tortorici, M. A., Bowen, J., Culap, K., Jaconi, S., Cameroni, E., Snell, G., Pizzuto, M. S., Pellanda, A. F., Garzoni, C., Riva, A., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Michael, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Mccoy, L. E., Smith, K. G. C., Bradley, J. R., Temperton, N., Ceron-Gutierrez, L., Barcenas-Morales, G., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Torok, M. E., Saeed, K., Prieto, J. A., Jackson, D. K., Hamilton, W. L., Snell, L. B., Moore, C., Harrison, E. M., Goncalves, S., Fairley, D. J., Loose, M. W., Watkins, J., Livett, R., Moses, S., Amato, R., Nicholls, S., Bull, M., Smith, D. L., Barrett, J., Aanensen, D. M., Curran, M. D., Parmar, S., Aggarwal, D., Shepherd, J. G., Parker, M. D., Glaysher, S., Bashton, M., Underwood, A. P., Pacchiarini, N., Loveson, K. F., Carabelli, A. M., Templeton, K. E., Langford, C. F., Sillitoe, J., de Silva, T. I., Wang, D., Kwiatkowski, D., Rambaut, A., O'Grady, J., Cottrell, S., Holden, M. T. G., Thomson, E. C., Osman, H., Andersson, M., Chauhan, A. J., Hassan-Ibrahim, M. O., Lawniczak, M., Alderton, A., Chand, M., Constantinidou, C., Unnikrishnan, M., Darby, A. C., Hiscox, J. A., Paterson, S., Martincorena, I., Robertson, D. L., Volz, E. M., Page, A. J., Pybus, O. G., Bassett, A. R., Ariani, C. V., Spencer Chapman, M. H., K. K., Li, Shah, R. N., Jesudason, N. G., Taha, Y., Mchugh, M. P., Dewar, R., Jahun, A. S., Mcmurray, C., Pandey, S., Mckenna, J. P., Nelson, A., Young, G. R., Mccann, C. M., Elliott, S., Lowe, H., Temperton, B., Roy, S., Price, A., Rey, S., Wyles, M., Rooke, S., Shaaban, S., de Cesare, M., Letchford, L., Silveira, S., Pelosi, E., Wilson-Davies, E., Hosmillo, M., O'Toole, A., Hesketh, A. R., Stark, R., du Plessis, L., Ruis, C., Adams, H., Bourgeois, Y., Michell, S. L., Gramatopoulos, D., Edgeworth, J., Breuer, J., Todd, J. A., Fraser, C., Buck, D., John, M., Kay, G. L., Palmer, S., Peacock, S. J., Heyburn, D., Weldon, D., Robinson, E., Mcnally, A., Muir, P., Vipond, I. B., Boyes, J., Sivaprakasam, V., Salluja, T., Dervisevic, S., Meader, E. J., Park, N. R., Oliver, K., Jeffries, A. R., Ott, S., da Silva Filipe, A., Simpson, D. A., Williams, C., Masoli, J. A. H., Knight, B. A., Jones, C. R., Koshy, C., Ash, A., Casey, A., Bosworth, A., Ratcliffe, L., Xu-McCrae, L., Pymont, H. M., Hutchings, S., Berry, L., Jones, K., Halstead, F., Davis, T., Holmes, C., Iturriza-Gomara, M., Lucaci, A. O., Randell, P. A., Cox, A., Madona, P., Harris, K. A., Brown, J. R., Mahungu, T. W., Irish-Tavares, D., Haque, T., Hart, J., Witele, E., Fenton, M. L., Liggett, S., Graham, C., Swindells, E., Collins, J., Eltringham, G., Campbell, S., Mcclure, P. C., Clark, G., Sloan, T. J., Jones, C., Lynch, J., Warne, B., Leonard, S., Durham, J., Williams, T., Haldenby, S. T., Storey, N., Alikhan, N. -F., Holmes, N., Carlile, M., Perry, M., Craine, N., Lyons, R. A., Beckett, A. H., Goudarzi, S., Fearn, C., Cook, K., Dent, H., Paul, H., Davies, R., Blane, B., Girgis, S. T., Beale, M. A., Bellis, K. L., Dorman, M. J., Drury, E., Kane, L., Kay, S., Mcguigan, S., Nelson, R., Prestwood, L., Rajatileka, S., Batra, R., Williams, R. J., Kristiansen, M., Green, A., Justice, A., Mahanama, A. I. K., Samaraweera, B., Hadjirin, N. F., Quick, J., Poplawski, R., Kermack, L. M., Reynolds, N., Hall, G., Chaudhry, Y., Pinckert, M. L., Georgana, I., Moll, R. J., Thornton, A., Myers, R., Stockton, J., Williams, C. A., Yew, W. C., Trotter, A. J., Trebes, A., MacIntyre-Cockett, G., Birchley, A., Adams, A., Plimmer, A., Gatica-Wilcox, B., Mckerr, C., Hilvers, E., Jones, H., Asad, H., Coombes, J., Evans, J. M., Fina, L., Gilbert, L., Graham, L., Cronin, M., Kumziene-Summerhayes, S., Taylor, S., Jones, S., Groves, D. C., Zhang, P., Gallis, M., Louka, S. F., Starinskij, I., Jackson, C., Gourtovaia, M., Tonkin-Hill, G., Lewis, K., Tovar-Corona, J. M., James, K., Baxter, L., Alam, M. T., Orton, R. J., Hughes, J., Vattipally, S., Ragonnet-Cronin, M., Nascimento, F. F., Jorgensen, D., Boyd, O., Geidelberg, L., Zarebski, A. E., Raghwani, J., Kraemer, M. U. G., Southgate, J., Lindsey, B. B., Freeman, T. M., Keatley, J. -P., Singer, J. B., de Oliveira Martins, L., Yeats, C. A., Abudahab, K., Taylor, B. E. W., Menegazzo, M., Danesh, J., Hogsden, W., Eldirdiri, S., Kenyon, A., Mason, J., Robinson, T. I., Holmes, A., Hartley, J. A., Curran, T., Mather, A. E., Shankar, G., Jones, R., Howe, R., Morgan, S., Wastenge, E., Chapman, M. R., Mookerjee, S., Stanley, R., Smith, W., Peto, T., Eyre, D., Crook, D., Vernet, G., Kitchen, C., Gulliver, H., Merrick, I., Guest, M., Munn, R., Bradley, D. T., Wyatt, T., Beaver, C., Foulser, L., Churcher, C. M., Brooks, E., Smith, K. S., Galai, K., Mcmanus, G. M., Bolt, F., Coll, F., Meadows, L., Attwood, S. W., Davies, A., De Lacy, E., Downing, F., Edwards, S., Scarlett, G. P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Betteridge, E., Farr, B. W., Goodwin, S., Quail, M. A., Scott, C., Shirley, L., Thurston, S. A. J., Rajan, D., Bronner, I. F., Aigrain, L., Redshaw, N. M., Lensing, S. V., Mccarthy, S., Makunin, A., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. J., Lackenby, A., Mbisa, T., Platt, S., Miah, S., Bibby, D., Manso, C., Hubb, J., Dabrera, G., Ramsay, M., Bradshaw, D., Schaefer, U., Groves, N., Gallagher, E., Lee, D., Williams, D., Ellaby, N., Hartman, H., Manesis, N., Patel, V., Ledesma, J., Twohig, K. A., Allara, E., Pearson, C., Cheng, J. K. J., Bridgewater, H. E., Frost, L. R., Taylor-Joyce, G., Brown, P. E., Tong, L., Broos, A., Mair, D., Nichols, J., Carmichael, S. N., Smollett, K. L., Nomikou, K., Aranday-Cortes, E., Johnson, N., Nickbakhsh, S., Vamos, E. E., Hughes, M., Rainbow, L., Eccles, R., Nelson, C., Whitehead, M., Gregory, R., Gemmell, M., Wierzbicki, C., Webster, H. J., Fisher, C. L., Signell, A. W., Betancor, G., Wilson, H. D., Nebbia, G., Flaviani, F., Cerda, A. C., Merrill, T. V., Wilson, R. E., Cotic, M., Bayzid, N., Thompson, T., Acheson, E., Rushton, S., O'Brien, S., Baker, D. J., Rudder, S., Aydin, A., Sang, F., Debebe, J., Francois, S., Vasylyeva, T. I., Zamudio, M. E., Gutierrez, B., Marchbank, A., Maksimovic, J., Spellman, K., Mccluggage, K., Morgan, M., Beer, R., Afifi, S., Workman, T., Fuller, W., Bresner, C., Angyal, A., Green, L. R., Parsons, P. J., Tucker, R. M., Brown, R., Whiteley, M., Bonfield, J., Puethe, C., Whitwham, A., Liddle, J., Rowe, W., Siveroni, I., Le-Viet, T., Gaskin, A., Johnson, R., Abnizova, I., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. C., Chapman, L., Chillingworth, T. -J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dougherty, M., Dove, A., Drummond, L., Dudek, M., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B., Fenton, M., Ferrero, M., Flack, N., Fordham, H., Forsythe, G., Francis, M., Fraser, A., Freeman, A., Galvin, A., Garcia-Casado, M., Gedny, A., Girgis, S., Glover, J., Gould, O., Gray, A., Gray, E., Griffiths, C., Gu, Y., Guerin, F., Hamilton, W., Hanks, H., Harrison, E., Harrott, A., Harry, E., Harvison, J., Heath, P., Hernandez-Koutoucheva, A., Hobbs, R., Holland, D., Holmes, S., Hornett, G., Hough, N., Huckle, L., Hughes-Hallet, L., Hunter, A., Inglis, S., Iqbal, S., Jackson, A., Jackson, D., Verdejo, C. J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Quail, M., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Seekings, P., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Van, P. J., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Widaa, S., Williams, M., Wilson, M., Wright, S., Harvey, W., Virgin, H. W., Lanzavecchia, A., Piccoli, L., Doffinger, R., Wills, M., Veesler, D., Corti, D., and Gupta, R. K.
- Subjects
0301 basic medicine ,Male ,Models, Molecular ,Passive ,Antibodies, Viral ,Neutralization ,0302 clinical medicine ,Models ,Monoclonal ,80 and over ,Viral ,Neutralizing antibody ,Neutralizing ,Aged, 80 and over ,Vaccines ,Vaccines, Synthetic ,Multidisciplinary ,biology ,Antibodies, Monoclonal ,C500 ,Middle Aged ,C700 ,Spike Glycoprotein ,Vaccination ,Spike Glycoprotein, Coronavirus ,Female ,Angiotensin-Converting Enzyme 2 ,Antibody ,Aged ,Antibodies, Neutralizing ,COVID-19 ,COVID-19 Vaccines ,HEK293 Cells ,Humans ,Immune Evasion ,Immunization, Passive ,Mutation ,Neutralization Tests ,SARS-CoV-2 ,medicine.drug_class ,B100 ,Monoclonal antibody ,Antibodies ,Virus ,03 medical and health sciences ,Immune system ,medicine ,COVID-19 Serotherapy ,QR355 ,Synthetic ,Molecular ,Virology ,Coronavirus ,030104 developmental biology ,Immunization ,biology.protein ,030217 neurology & neurosurgery - Abstract
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries. It is unclear whether the response of the virus to vaccines against SARS-CoV-2 on the basis of the prototypic strain will be affected by the mutations found in B.1.1.7. Here we assess the immune responses of individuals after vaccination with the mRNA-based vaccine BNT162b22. We measured neutralizing antibody responses after the first and second immunizations using pseudoviruses that expressed the wild-type spike protein or a mutated spike protein that contained the eight amino acid changes found in the B.1.1.7 variant. The sera from individuals who received the vaccine exhibited a broad range of neutralizing titres against the wild-type pseudoviruses that were modestly reduced against the B.1.1.7 variant. This reduction was also evident in sera from some patients who had recovered from COVID-19. Decreased neutralization of the B.1.1.7 variant was also observed for monoclonal antibodies that target the N-terminal domain (9 out of 10) and the receptor-binding motif (5 out of 31), but not for monoclonal antibodies that recognize the receptor-binding domain that bind outside the receptor-binding motif. Introduction of the mutation that encodes the E484K substitution in the B.1.1.7 background to reflect a newly emerged variant of concern (VOC 202102/02) led to a more-substantial loss of neutralizing activity by vaccine-elicited antibodies and monoclonal antibodies (19 out of 31) compared with the loss of neutralizing activity conferred by the mutations in B.1.1.7 alone. The emergence of the E484K substitution in a B.1.1.7 background represents a threat to the efficacy of the BNT162b2 vaccine.
- Published
- 2021
27. Intelligent grinding assistant (IGA(©)) - system development part I intelligent grinding database
- Author
-
Cai, R., Rowe, W. B., Moruzzi, J. L., and Morgan, M. N.
- Published
- 2007
- Full Text
- View/download PDF
28. Tribology and Fundamentals of Abrasive Machining Processes Ed. 3
- Author
-
Azarhoushang, Bahman, Marinescu, Ioan D., Rowe, W. Brian, Azarhoushang, Bahman, Azarhoushang, Bahman, Marinescu, Ioan D., Rowe, W. Brian, and Azarhoushang, Bahman
- Abstract
This new edition draws upon the fundamentals of abrasive machining processes and the science of tribology to understand, predict, and improve abrasive machining processes. Each of the main elements of the abrasive machining system is looked at alongside the tribological factors that control the efficiency and quality of the processes described. The new edition has been updated to include a variety of industrial applications. Grinding and conditioning of grinding tools are dealt with in particular detail, and solutions are proposed for many of the most commonly experienced industrial problems, such as poor accuracy, poor surface quality, rapid tool wear, vibrations, workpiece burn, and high process costs. The entire book has been rewritten and restructured, with ten completely new chapters. Other new features include: Extensive explanations of the main abrasive machining processes such as grinding (including reciprocating and creep-feed grinding, high-speed high-efficiency deep grinding, external and internal cylindrical grinding, and centerless grinding), honing, superfinishing, lapping, polishing, and finishing Discussions of the new classes of abrasives, abrasive tools, and bonding materials New case studies and troubleshooting on the most common grinding practices New coverage on grinding tool conditioning, mechanical dressing, and nonmechanical dressing processes Detailed explanations of the effects of process input parameters (such as cutting parameters, workpiece material and geometry, and abrasive tools) on process characteristics, workpiece quality, tool wear, and process parameters (such as cutting forces and temperature as well as achievable material removal rate) Updated topics regarding process fluids for abrasive machining and fluid delivery
- Published
- 2021
29. Gap solitons supported by mode hybridisation in lithium niobate nanowaveguides
- Author
-
Rowe, W. R., Gorbach, A. V., Fergestad, Halvor, Gallo, Katia, Skryabin, D. V., Rowe, W. R., Gorbach, A. V., Fergestad, Halvor, Gallo, Katia, and Skryabin, D. V.
- Abstract
Part of proceedings: ISBN 978-155752820-9 Not duplicate with DiVA 1639407QC 20230831
- Published
- 2021
30. Developmental progress in conducting action research
- Author
-
Piggot-Irvine, E, Ferkins, L, Rowe, W, Sankaran, S, Cady, P, Piggot-Irvine, E, Ferkins, L, Rowe, W, Sankaran, S, and Cady, P
- Abstract
This book will be a valuable resource for: action researchers throughout the world; postgraduate research students, academics and libraries; evaluators; and anyone in communities who wishes to know how to create sustainable change.
- Published
- 2021
31. The evaluative study of action research: Rigorous findings on process and impact from around the world
- Author
-
Piggot-Irvine, E, Ferkins, L, Rowe, W, Sankaran, S, Piggot-Irvine, E, Ferkins, L, Rowe, W, and Sankaran, S
- Published
- 2021
32. Introduction
- Author
-
Piggot-Irvine, E, Ferkins, L, Rowe, W, Sankaran, S, Piggot-Irvine, E, Ferkins, L, Rowe, W, and Sankaran, S
- Abstract
This book will be a valuable resource for: action researchers throughout the world; postgraduate research students, academics and libraries; evaluators; and anyone in communities who wishes to know how to create sustainable change.
- Published
- 2021
33. The Crinoids of Madagascar
- Author
-
Marshall, Janet I, Rowe, W E, and BioStor
- Published
- 1981
34. The Novels of Jose Maria Arguedas
- Author
-
Rowe, W. W.
- Subjects
860 - Published
- 1975
35. An integrated national scale SARS-CoV-2 genomic surveillance network
- Author
-
Aanensen, DM, Abudahab, K, Adams, A, Afifi, S, Alam, MT, Alderton, A, Alikhan, N-F, Allan, J, Almsaud, M, Alrezaihi, A, Alruwaili, M, Amato, R, Andersson, M, Angyal, A, Aranday-Cortes, E, Ariani, C, Armstrong, SD, Asamaphan, P, Attwood, S, Aydin, A, Badhan, A, Baker, D, Baker, P, Balcazar, CE, Ball, J, Barton, AE, Bashton, M, Baxter, L, Beale, M, Beaver, C, Beckett, A, Beer, R, Beggs, A, Bell, A, Bellis, KL, Bentley, EG, Berriman, M, Betteridge, E, Bibby, D, Bicknell, K, Birchley, A, Black, G, Blane, B, Bloomfield, S, Bolt, F, Bonsall, DG, Bosworth, A, Bourgeois, Y, Boyd, O, Bradshaw, D, Breuer, J, Bridgewater, H, Brooks, T, Broos, A, Brown, JR, Brown, RL, Brunker, K, Bucca, G, Buck, D, Bull, M, Butcher, E, Caddy, SL, Caller, LG, Cambell, S, Carlile, M, Carmichael, S, Carrilero, L, Castellano, S, Chaloner, J, Chand, M, Chapman, MR, Chappell, J, Charles, I, Chauhan, AJ, Chawla, A, Cheng, E, Churcher, CM, Clark, G, Clark, JJ, Collins, J, Colquhoun, R, Connor, TR, Constantinidou, C, Coombes, J, Corden, S, Cottrell, S, Cowell, A, Curran, MD, Curran, T, Dabrera, G, Danesh, J, Darby, AC, De Cesare, M, Martins, LDO, De Silva, TI, Debebe, B, Dervisevic, S, Dewar, RA, Dia, M, Dorman, M, Dougan, G, Dover, L, Downing, F, Drury, E, Du Plessis, L, Dyal, PL, Eccles, R, Edwards, S, Ellaby, N, Elliott, S, Eltringham, G, Elumogo, N, Essex, S, Evans, CM, Evans, J, Nascimento, FF, Fairley, DJ, Farr, B, Feltwell, T, Ferguson, N, Filipe, ADS, Findlay, J, Forrest, LM, Forrest, S, Foulser, L, Francois, S, Fraser, C, Frost, L, Gallagher, E, Gallagher, MD, Garcia-Dorival, I, Gaskin, A, Gatica-Wilcox, B, Gavriil, A, Geidelberg, L, Gemmell, M, Gerada, A, Gifford, L, Gilbert, L, Gilmore, P, Gilroy, R, Girgis, S, Glaysher, S, Golubchik, T, Goncalves, S, Goodfellow, I, Goodwin, S, Graham, C, Graham, L, Grammatopoulos, D, Green, A, Green, LR, Greenaway, J, Gregory, R, Groves, DC, Groves, N, Guest, M, Gunson, R, Haldenby, S, Hall, G, Hamilton, WL, Han, X, Harris, KA, Harrison, EM, Hartley, C, Herrera, C, Hesketh, A, Heyburn, D, Hill, V, Hiscox, JA, Holden, M, Holmes, A, Holmes, N, Holt, GS, Hopes, R, Hosmillo, M, Houldcroft, CJ, Howson-Wells, H, Hubb, J, Hughe, J, Hughes, M, Hutchings, S, Impey, R, Iturriza-Gomara, M, Jackson, A, Jackson, B, Jackson, DK, Jahun, AS, James, K, Jamrozy, D, Jeffries, A, Jesudason, N, John, M, Johnson, J, Johnson, KJ, Johnson, N, Johnston, I, Jones, B, Jones, R, Jones, S, Jorgensen, D, Kane, L, Kay, GL, Kay, S, Keatley, J-P, Keeley, AJ, Khakh, M, Khokhar, FA, Kitchen, C, Knight, B, Kolyva, A, Kraemer, M, Kristiansen, M, Kumziene-Summerhayes, S, Kwiatkowski, D, Lackenby, A, Langford, C, Lawniczak, M, Thanh, L-V, Lee, D, Letchford, L, Li, K, Li, L, Liggett, S, Lindsey, BB, Livett, R, Lloyd, A, Lo, S, Lockhart, M, Loh, J, Loman, NJ, Loose, M, Lucaci, A, Ludden, C, Luu, L, Lyons, RA, MacIntyre-Cockett, G, MacLean, A, Mair, D, Maksimovic, J, Manley, R, Manso, C, Manson, J, Martincorena, I, Masoli, J, Mather, AE, Mbisa, T, McCluggage, K, McClure, P, McCrone, JT, McDonald, S, McHugh, MP, McKenna, JM, McMinn, L, McMurray, C, Meadows, L, Menegazzo, M, Meredith, LW, Merrick, I, Mestek-Boukhibar, L, Miah, S, Michell, S, Michelsen, ML, Molnar, Z, Moore, C, Moore, N, Morgan, M, Morgan, S, Muddyman, D, Muir, DA, Muir, P, Myers, R, Nastouli, E, Naydenova, P, Nelson, A, Nelson, C, Nelson, R, Nicholls, S, Nichols, J, Niebel, M, Niola, P, Nomikou, K, O'Grady, J, O'Toole, AN, O'Toole, E, Olateju, C, Orton, RJ, Osman, H, Ott, S, Pacchiarini, N, Padgett, D, Page, AJ, Palmer, S, Panchbhaya, YN, Pandey, S, Park, N, Parker, MD, Parkhill, J, Parr, YA, Parsons, PJ, Partridge, DG, Patel, M, Patterson, S, Payne, B, Peacock, SJ, Penrice-Randal, R, Perry, M, Platt, S, Poplawski, R, Prakash, R, Prestwood, L, Price, A, Price, JR, Puethe, C, Pybus, O, Pymont, H, Quail, M, Quick, J, Raghwani, J, Ragonnet-Cronin, M, Rahman, S, Rainbow, L, Rajatileka, S, Rambaut, A, Ramsay, M, Randell, PA, Randle, NP, Raviprakash, V, Raza, M, Silva, PR, Rey, S, Richter, A, Robertson, DL, Robinson, TI, Robson, SC, Rooke, S, Rowan, A, Rowe, W, Roy, S, Rudder, S, Ruis, C, Sang, F, Scarlett, G, Schaefer, U, Scott, C, Scott, G, Sethi, D, Shaaban, S, Shah, R, Sharma, P, Shawli, GT, Shepherd, J, Sherriff, N, Shirley, L, Sillitoe, J, Simpson, DA, Singer, JB, Siveroni, I, Smith, C, Smith, CP, Smith, DL, Smith, N, Smith, W, Smith-Palmer, A, Smollett, K, Southgate, J, Spellman, K, Spencer-Chapman, M, Sridhar, S, Stanley, R, Stark, R, Stewart, JP, Stockton, J, Stuart, C, Studholme, D, Swainston, N, Swindells, E, Taha, Y, Tariq, MA, Taylor, B, Taylor, GP, Taylor, S, Taylor-Joyce, G, Tedim, AP, Temperton, B, Templeton, KE, Thomson, EC, Thomson, NM, Thornton, A, Thurston, S, Todd, J, Tong, L, Tonkin-Hill, G, Torok, ME, Trebes, A, Trotter, AJ, Tsoleridis, T, Tucker, RM, Tutill, HJ, Underwood, A, Unnikrishnan, M, Vamos, E, Vasylyeva, T, Vattipally, S, Victoria, A, Vipond, B, Volz, EM, Wain, J, Wang, D, Warwick-Dugdale, J, Wastnedge, E, Watkins, J, Watts, J, Webber, M, Weeks, S, Weldon, D, Whitehead, M, Williams, CA, Williams, C, Williams, D, Williams, R, Williams, TC, Wise, E, Wright, V, Wyles, MD, Wyllie, S, Yakovleva, A, Yasir, M, Yeats, C, Yew, WC, Young, GR, Yu, X, and Zarebski, A
- Subjects
Microbiology (medical) ,Scale (ratio) ,SARS-CoV-2 ,viruses ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,COVID-19 ,COVID-19 Genomics UK (COG-UK) consortiumcontact@cogconsortium.uk ,C500 ,Genome, Viral ,Genomics ,Biology ,C700 ,Microbiology ,Article ,Infectious Diseases ,Virology ,Humans ,Cartography - Abstract
The Coronavirus Disease 2019 (COVID-19) Genomics UK Consortium (COG-UK) was launched in March, 2020, with £20 million support from UK Research and Innovation, the UK Department of Health and Social Care, and Wellcome Trust. The goal of this consortium is to sequence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for up to 230 000 patients, health-care workers, and other essential workers in the UK with COVID-19, which will help to enable the tracking of SARS-CoV-2 transmission, identify viral mutations, and integrate with health data to assess how the viral genome interacts with cofactors and consequences of COVID-19.
- Published
- 2020
- Full Text
- View/download PDF
36. Some studies of the centreless grinding process with particular reference to the roundness accuracy
- Author
-
Rowe, W. B.
- Subjects
670 ,Industrial processes & manufacturing processes - Published
- 1964
37. The GE paradox: competitive advantage through fungible non-firm-specific investment
- Author
-
Lehmberg, Derek, Rowe, W. Glenn, White, Roderick E., and Philips, John R.
- Subjects
General Electric Co. -- Human resource management ,Management training -- Methods ,Management development programs -- Analysis ,Electrical equipment and supplies industry -- Human resource management ,Company personnel management ,Business ,Business, general - Abstract
The ability of General Electric (GE) to develop non-firm-specific general management talent is examined. The study provides a theory suggesting that GE's managerial development program is rare, valuable, inimitable, and organized to be exploited. However, as byproduct of the process, several GE managers have the tendency to leave the firm for employment elsewhere.
- Published
- 2009
38. Temperature control in CBN grinding
- Author
-
Rowe, W. B., Black, S. C. E., and Mills, B.
- Published
- 1996
- Full Text
- View/download PDF
39. Robots for grinding?
- Author
-
Brian Rowe, W.
- Published
- 1998
- Full Text
- View/download PDF
40. Lymphocytic Choriomeningitis Infection in Neonatally Thymectomized Mice Bearing Diffusion Chambers Containing Thymus
- Author
-
Levey, R. H., Trainin, N., Law, L. W., Black, P. H., and Rowe, W. P.
- Published
- 1963
41. Ethical leadership then and now
- Author
-
Makris, Nicole Davey and Rowe, W. Glenn
- Subjects
Enron Creditors Recovery Corp. -- Ethical aspects ,Verizon Business Network Services Inc. -- Ethical aspects ,Gas transmission industry -- Ethical aspects ,Telecommunications services industry -- Ethical aspects ,Leadership ,Communications industry -- Ethical aspects ,Telecommunications services industry ,Business, general ,Business ,Business, international - Abstract
There is no question that the 2008 financial crisis intensified the spotlight on executive behaviour created by the Enron and WorldCom accounting scandals that previously rocked the business world (in [...]
- Published
- 2015
42. Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions
- Author
-
Talavera, D., Kershaw, C.J., Costello, J.L., Castelli, L.M., Rowe, W., Sims, P.F.G., Ashe, M.P., Grant, C.M., Pavitt, G.D., and Hubbard, S.J.
- Abstract
The transcriptional responses of yeast cells to diverse stresses typically include gene activation and repression. Specific stress defense, citric acid cycle and oxidative phosphorylation genes are activated, whereas protein synthesis genes are coordinately repressed. This view was achieved from comparative transcriptomic experiments delineating sets of genes whose expression greatly changed with specific stresses. Less attention has been paid to the biological significance of 1) consistent, albeit modest, changes in RNA levels across multiple conditions, and 2) the global gene expression correlations observed when comparing numerous genome-wide studies. To address this, we performed a meta-analysis of 1379 microarray-based experiments in yeast, and identified 1388 blocks of RNAs whose expression changes correlate across multiple and diverse conditions. Many of these blocks represent sets of functionally-related RNAs that act in a coordinated fashion under normal and stress conditions, and map to global cell defense and growth responses. Subsequently, we used the blocks to analyze \ud novel RNA-seq experiments, demonstrating their utility and confirming the conclusions drawn from the meta-analysis. Our results provide a new framework for understanding the biological significance of changes in gene expression: ‘archetypal’ transcriptional blocks that are regulated in a concerted fashion in response to external stimuli.
- Published
- 2018
43. Evolocumab and clinical outcomes in patients with cardiovascular disease
- Author
-
Sabatine, Marc S., Giugliano, Robert P., Keech, Anthony C., Honarpour, Narimon, Wiviott, Stephen D., Murphy, Sabina A., Kuder, Julia F., Wang, Huei, Liu, Thomas, Wasserman, Scott M., Sever, Peter S., Pedersen, Fish MP, Terje R., Abrahamsen, Te, Im, K, Kanevsky, E, Bonaca, Mp, Lira Pineda, A, Hanlon, K, Knusel, B, Somaratne, R, Kurtz, C, Scott, R, Accini Mendoza JL, Amerena, J, Badariene, J, Burgess, L, Ceska, R, Charng, Mj, Choi, D, Cobos, Jl, Dan, Ga, De Ferrari GM, Deedwania, Pc, Chopra, Vk, Erglis, A, Ezhov, Mv, Ferreira, J, Filipová, S, Gaciong, Za, Pasierski, T, Georgiev, Bg, Gonzalez-Galvez, G, Gouni-Berthold, I, Schäufele, T, Hirayama, A, Huber, K, Rammer, M, Kjaerulf Jensen, H, Wermuth, S, Jiang, L, Jukema, Jw, Kraydashenko, O, Leiter, La, Lewis, Bs, López-Miranda, J, Lorenzatti, Aj, Mach, F, Mcadam, B, Nilsson, L, Olsson, Å, Rallidis, L, Rogelio, Gg, Kerr Saraiva JF, Scheen, A, Schiele, F, Scott, Rs, Connolly, D, Siu, Cw, Tay, L, Thorgeirsson, G, Tikkanen, Mj, Tokgozoglu, Sl, Toth, K, Viigimaa, M, Wan Ahmad WA, Hennekens, Ch, Andreotti, F, Baigent, C, Brown, Wv, Davis, Br, Newcomer, Jw, Wood, Sk, Larosa, J, Ansell, B, Olsson, A, Lowe, C, Zahn, L, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Mackinnon, I, Vogel, Dr, Leon de la Fuente, R, Perna, E, Amuchastegui, M, Pacora, F, Hershson, A, Blumberg, E, Glenny, Ja, Colombo, H, Cuadrado, Ja, Nicolosi, L, Rojas, Cg, Ulla, Mr, Hasbani, Eg, Cuneo, C, Lopez Santi RG, Sanabria, Hd, Hrabar, A, Lozada, A, Begg, A, Lehman, S, Wittert, G, Juergens, C, Kostner, K, Beltrame, J, Simpson, R, Sinhal, A, Adams, M, Kritharides, L, Roberts Thomson, P, Cross, D, Thompson, P, Van Gaal, W, Cox, N, Farshid, A, Hammett, C, Garrahy, P, Prasan, A, Horrigan, M, Ebenbichler, C, Hanusch, U, Prager, R, Schernthaner, G, Luger, A, Siostrzonek, P, Toplak, H, Bergler-Klein, J, Paulweber, B, Sinzinger, H, Buysschaert, I, Thoeng, J, Vandekerckhove, H, Catez, E, Verheye, S, Descamps, O, Hoffer, E, Wollaert, B, Chenu, P, van de Borne, P, De Meulemeester, M, Friart, A, Charlier, F, De Raedt, H, Rietzschel, E, Roelandt, R, Lalmand, J, Tavares Russo LA, Reis, G, Duarte Barbosa EC, Vidotti, Mh, Fernandes Manenti ER, Dutra, O, Leaes, Pe, Rech, Rl, Bertolim Precoma, D, Nicolau, Jc, Amoedo, R, Eliaschewitz, Fg, Pereira, A, Kurtz Lisboa HR, Soares Piegas, L, Cunha Borges JL, Ferreira Rossi PR, Pimentel Filho, P, Bodanese, Lc, de Sa Cunha, R, Moura Jorge JC, Ardito, Wr, Barroso de Souza WK, Hissa, M, Izar, Mc, Manolova, A, Kitova, L, Kinova, E, Tzekova, M, Velchev, V, Tarnovska-Kadreva, R, Gotchev, D, Petrov, I, Raev, D, Trendafilova-Lazarova, D, Yotov, Y, Lazov, P, Rahimi, S, St Amour, E, Constance, C, Pesant, Y, Hess, A, Anderson, T, Sussex, B, Henein, S, Tsoukas, G, Pandey, As, Bergeron, J, Hart, R, Gosselin, G, Chehayeb, R, Hamet, P, Hartleib, M, Mukherjee, A, Halperin, F, Petrella, R, Bhargava, R, Lonn, E, Sabbah, E, Bata, I, Cha, J, Gaudet, D, Chapman, K, Murthy, D, Nigro, F, Rupka, D, Gossard, D, Gupta, M, Dowell, A, Mansour, S, Baass, A, Geadah, C, Huynh, T, Peterson, S, Poirier, P, Sabe-Affaki, G, Vertes, G, Crowley, D, Duchesne, L, Pincetti Jofre CP, Potthoff Cardenas, S, Conejeros Kindel, C, Saavedra Gajardo VA, Lanas Zanetti, F, Sepulveda Varela PA, Stockins Fernandez BA, Li, W, Li, D, Zhao, S, Li, Z, Wang, J, Yang, Y, Zhang, L, Yang, P, Zhang, X, Huang, H, Xue, L, Zheng, Z, Huang, W, Dai, H, Su, H, Zeng, X, Zheng, Y, Tang, Y, Yao, Z, Sun, Y, Du, Y, Ge, Z, Yan, J, Chen, X, Liu, F, Pei, H, Yang, X, Cui, H, Gu, Y, Yang, Z, Li, J, Lian, Y, Cui, Y, Wang, D, Jiang, J, Li, X, Chen, J, Mo, Z, Xu, P, He, Y, Zhou, C, Qu, P, Zhu, Y, Liu, Y, Shen, X, Gao, X, Terront Lozano MA, Moncada Corredor MA, Hernandez Triana, E, Botero Lopez, R, Coronel Arroyo JA, Quintero Baiz AE, Sanchez Vallejo, G, Arana Londoño, C, Molina de Salazar DI, Castellanos Bueno, R, Manzur Jattin, F, Cure Cure CA, Sotomayor Herazo, A, Spinar, J, Hala, T, Machkova, M, Klimsa, Z, Polasek, R, Jerabek, O, Kazdera, P, Pozdisek, Z, Vaclavik, J, Frana, P, Elbl, L, Kucera, D, Kryza, R, Malecha, J, Reichert, P, Sochor, K, Ludka, O, Kellnerova, I, Peterka, K, Zidkova, E, Cech, V, Brabec, T, Fiserova, N, Kvasnicka, J, Rosolova, H, Nemecek, E, Adamkova, V, Dunaj, M, Pojsl, S, Cepelak, M, Podpera, I, Kuchar, L, Rysava, D, Burianova, H, Spinarova, L, Skrobakova, J, Charvat, J, Homza, M, Zemanek, J, Koleckar, P, Karen, I, Krupicka, J, Blaha, V, Matuska, J, Brotanek, J, Cifkova, R, Kuchar, R, Vomacka, Z, Kosek, Z, Hulinsky, V, Krejcova, H, Kuchar, J, Jelinek, Z, Jelinek, P, Markdanner Lindgren, L, Saetre Lihn, A, Korsgaard Thomsen, K, Bronnum-Schou, J, Nielsen, H, Nielsen, T, Egstrup, K, Klausen, Ic, Mickley, H, Hove, J, Jeppesen, J, Melchior, T, Schmidt, Eb, Valter, I, Rosenthal, A, Kaik, J, Kork, A, Alt, I, Strand, J, Nieminen, S, Kahri, J, Suomi, J, Nyman, K, Strandberg, Te, Piippo, T, Savolainen, M, Vikman, S, Pucheu, Y, Cariou, B, Henry, P, Ferrari, E, Montalescot, G, Ferrieres, J, Roubille, F, Bonnet, B, Angoulvant, D, Range, G, Bammert, A, Delarche, N, Mariat, C, Cayla, G, Durlach, V, Coisne, D, Paillard, F, Rouzier, R, Goralski, M, Khanoyan, P, Cottin, Y, Ziegler, O, Khalife, K, Le Corvoisier, P, Motreff, P, Spaulding, C, Vanbelle, E, Bourhaial, H, Opitz, C, Kahrmann, G, Contzen, C, Appel, K, Schenkenberger, I, Rinke, A, Trenk, D, Maus, O, Karakas, M, Hanefeld, M, Darius, H, Hetzel, G, Münzel, T, Wöhrle, J, Stawowy, P, Marten, I, Isermann, B, Kast, P, Vorpahl, M, Bosiljanoff, P, Hengstenberg, C, Kassner, U, Salbach, P, Fischer, M, Steiner, S, Wagner, S, Kraatz, U, von Hodenberg, E, Weyland, K, Mantas, I, Tziakas, D, Bousboulas, S, Patsilinakos, S, Mertzanos, G, Panagoulis, C, Bilianou, H, Skoumas, I, Elisaf, M, Manolis, A, Moschos, N, Kochiadakis, G, Ntaios, G, Richter, D, Athyros, V, Kolovou, G, Danias, P, Melidonis, A, Fan, Kyy, Siu, Sc, Hornyik, A, Lakatos, F, Zilahi, Z, Nagy, K, Laszlo, Z, Peterfai, E, Lupkovics, G, Andreka, P, Merkely, B, Herczeg, B, Piros, Ga, Salamon, C, Mark, L, Papp, A, Szakal, I, Edes, I, Mohacsi, A, Tomcsanyi, J, Hajko, E, Nagy, A, Papp, E, Kiss, R, Karadi, I, Sigurdsson, A, Jain, A, Pai, R, Kothiwale, V, Kulkarni, G, Mahajan, A, Aggarwal, S, Mehta, V, Rajadhyaksha, G, Joshi, A, Khandait, V, Parmar, M, Tyagi, S, Airody Govinda, R, Dwivedi, Sk, Parikh, K, Pothineni, Rb, Solanki, B, O’Donnell, M, Crean, P, Barton, J, Shechter, M, Shotan, A, Klutstein, M, Chorin, E, Gavish, D, Kracoff, O, Atar, S, Rigler, S, Hasin, Y, Schiff, E, Merlini, P, Rapezzi, C, Pirro, M, Gonnelli, S, Floresta, Am, Mennuni, M, Ardissino, D, Senni, M, Marenzi, G, Marcucci, R, Sampietro, T, Cosmi, F, Perrone Filardi, P, De Caterina, R, Fedele, Francesco, Moretti, L, Biasucci, Lm, Ferri, C, Go, Y, Kiyosue, A, Higashi, Y, Tokunaga, T, Kawasaki, T, Sakagami, S, Namba, S, Saku, K, Oku, K, Arakawa, T, Iida, H, Nakamura, Y, Yamamoto, K, Hata, Y, Katsuda, Y, Koga, Y, Shimizu, M, Uehara, H, Kajiyama, S, Okamoto, H, Shinozaki, T, Fujino, Y, Funazaki, T, Higa, N, Kaigawa, K, Koike, A, Nakane, H, Sato, K, Satoh, Y, Shirasawa, K, Sugino, H, Tanabe, J, Uemura, O, Yoshimichi, G, Akai, A, Himeno, H, Inage, T, Inoko, M, Kadokami, T, Noguchi, Y, Yamashita, K, Yasumura, Y, Yuge, M, Hosokawa, S, Kawamitsu, K, Kozuma, K, Matsuo, H, Nakashima, E, Okada, M, Wada, A, Yokoya, K, Iwade, K, Kawabata, K, Tanno, H, Ako, J, Fujita, H, Izumiya, Y, Kanno, M, Nunohiro, T, Ohmura, H, Ueno, T, Kakurina, N, Jasinkevica, I, Stukena, I, Veze, I, Eglite, R, Teterovska, D, Sime, I, Strazdiene, V, Venceviciene, L, Gustiene, O, Radzeviciene-Jurgute, R, Kucinskiene, A, Maskon, O, Lee, Cy, Erng, T, Gan, Hw, Mohamed Yusof AK, Ramanathan, Gl, Liew, H, Lopez Alvarado, A, Nevarez Ruiz LA, De los Rios Ibarra MO, Bazzoni Ruiz AE, Ramos Lopez GA, Llamas Esperon GA, De la Peña Topete GDJ, Violante Ortiz RM, Illescas Diaz JJ, Leon Gonzalez, S, Sanchez Diaz CJ, Mendez Machado GF, Venegas Carrillo LA, Aldrete Velasco JA, Cardona Muñoz EG, Leiva Pons JL, Perez Alva JC, van der Zwaan, C, Oomen, A, van de Wal, R, Magro, M, Boswijk, D, Janus, C, Groutars, R, Tonino, W, Cornel, Jh, Oude Ophuis, A, Troquay, R, Liem, A, Westendorp, I, Van Hessen, M, Lok, D, De Nooijer, C, Den Hartog, F, Van Beek, E, Bendermacher, P, Jansen, R, Römer, T, Rensing, B, Hersbach, F, Herrman, J, Ladyjanskaia, G, Karalis, I, Linssen, G, Bokern, M, Visman, A, Kooij, A, Monajemi, H, Lieverse, A, Baker, J, Tie, S, Risberg, K, Hysing, J, Pedersen, T, Hoivik, Ho, Norheim, P, Solnor, L, Hovland, A, Kjaernli, T, Jocson, G, Coching, Rm, Batalla, E, Go, A, Habaluyas, R, Barcinas, R, Sy, Ra, Estepar, Ra, Germar, A, Trebacz, J, Szymkowiak, K, Wnetrzak-Michalska, R, Kopaczewski, J, Przekwas-Jaruchowska, M, Kania, G, Zabowka, M, Mirek-Bryniarska, E, Dabrowska, M, Napora, P, Konieczny, M, Spyra, J, Lysek, R, Pijanowski, Z, Grzegorzewski, B, Bednarkiewicz, Z, Kinasz, L, Antkowiak-Piatyszek, K, Stania, K, Szpajer, M, Staneta, P, Skonieczny, G, Ksiezycka-Majczynska, E, Blicharski, T, Piepiorka, M, Wozakowska-Kaplon, B, Zechowicz, T, Ilkowski, J, Lubiszewska, B, Hiczkiewicz, J, Wierzbicka, K, Kosior, D, Garbocz, P, Kubica, J, Raczak, G, Wozniak, I, Cygler, J, Kramarczuk, E, Bystryk, L, Pentela-Nowicka, J, Dabrowski, M, Podolec, P, Zieba, B, Mosiewicz, J, Dubaniewicz, W, Banach, M, Tyszecka, G, Lepich, T, Rychlewska-Hanczewska, A, Guzik, T, Monteiro, P, Pereira, H, Oliveira, L, Matos, P, Soares Goncalves, S, Leitao, A, Vasco Salgado, A, Timoteo, At, Pintilei, E, Badila, E, Militaru, C, Tudoran, M, Arsenescu-Georgescu, C, Mitu, F, Zdrenghea, D, Lighezan, D, Teodorescu, I, Popescu, Mi, Coman, I, Vintila, Mm, Vishnevsky, A, Lukyanov, Y, Blokhin, A, Kostenko, V, Shvarts, Y, Markov, V, Motylev, I, Dronov, D, Sherenkov, A, Barbarash, O, Shutemova, E, Bolshakova, O, Kobalava, Z, Voevoda, M, Treshkur, T, Zrazhevskiy, K, Pimenov, L, Solovev, O, Tarasov, N, Arkhipov, M, Freidlin, M, Shalaev, S, Yakhontova, P, Shustov, S, Goloshchekin, B, Panov, A, Bart, B, Bubnova, M, Gordeev, I, Osipova, I, Tereshenko, S, Solovieva, E, Meshkov, A, Zateyshchikov, D, Tan, Jl, Subramaniam, T, Pella, D, Fulop, P, Antalik, L, Dzupina, A, Banikova, A, Sosovec, D, Urgeova, L, Mazur, J, Hranai, M, Banik, M, Vinanska, D, Lennerova, J, Kovar, F, Pastrnakova, E, Uhliar, R, Blasko, P, Gonsorcik, J, Lukacova, J, Oriesek, R, Hatalova, K, du Toit, M, Ebrahim, I, Vawda, G, Lipschitz, S, Blignaut, S, Engelbrecht, J, Coetzer, Tf, Pretorius, M, Urbach, D, Badat, A, Pillay, S, Van Zyl, L, Abelson, M, van der Walt, E, Moodley, R, Jacovides, A, Oosthuysen, Wm, Klug, E, Lottering, H, Kok, J, Saaiman, J, Dawood, S, De Jong DM, Kapp, C, Makotoko, E, Bayat, J, Sarvan, M, Vally, T, Stapelberg, A, Kim, M, Bae, J, Cho, Y, Kim, S, Han, Kh, Her, S, Kim, B, Lee, S, Hong, B, Kim, W, Rha, S, Jeong, M, Shin, Gj, Vida Gutierrez, M, Valdes Chavarri, M, Pinto Sala, X, Gonzalez Juanatey JR, Civeira Murillo, F, Zamorano Gomez JL, Lekuona Goya, I, Iñiguez Romo, A, Cordero Fort, A, Ascaso Gimilio JF, Millan Nuñez-Cortes, J, Lindholm, C, Söderberg, S, Suutari, A, Berglund, S, Mooe, T, Kusiak, D, Bandh, S, Dahlén, G, Olsson, S, Witt, N, Tydén, P, Johansson, P, Cizinsky, S, Falck, G, Pettersson, Si, Rasmanis, G, Östergren, J, Moccetti, T, Beer, Hj, Eberli, F, Krähenbühl, S, Linka, A, Ackermann, D, Michel, P, Yeh, H, Tsai, Cf, Wu, C, Hsia, C, Juang, J, Hsieh, I, Lai, W, Huang, C, Hsieh, Y, Sahin, T, Duzenli, M, Yigit, Z, Demir, M, Yilmaz, Mb, Muderrisoglu, Ih, Kirma, C, Ercan, E, Kayikcioglu, L, Balbay, Y, Lymar, I, Kulynych, O, Prokhorov, O, Karpenko, O, Kraіz, I, Vakaliuk, I, Stanislavchuk, M, Korzh, O, Rudyk, I, Zhurba, S, Svishchenko, Y, Tseluyko, V, Gyrina, O, Reshotko, D, Kopytsya, M, Volkov, V, Myshanych, G, Rebrov, B, Rishko, M, Rudenko, L, Shatylo, V, Parkhomenko, O, Yena, L, Golovchenko, O, Sorokina, I, Malynovsky, Y, Ivan, P, Blagden, M, Dear, H, Mathew, A, Lagocki, S, Kondagunta, V, Ahsan, A, Mckinnon, C, Douglas, F, Thom, S, Fiore, G, Caulfield, M, Lynch, M, Thomas, H, Bain, S, Hall, A, Mcnally, D, Fisher, M, Keeling, P, Al-Bahrani, A, Lip, G, Ellery, A, Purohit, J, Travill, C, Cappuccio, F, Davis, G, Gaunt, R, Adlam, D, Asamoah, N, Jaafar, F, Mccormack, T, Jupp, B, Pye, M, Ainsworth, P, Chauhan, A, Paul, N, Fairlie, H, Fox, C, Muzulu, S, Trevelyan, J, Aggarwal, R, Issa, B, Saravanan, P, Cruickshank, K, Gorog, D, Heller, S, Newby, D, Nicolson, A, Hare, Po, Donnelly, P, Rutherfurd, S, de Belder, M, Finlayson, J, Harvey, J, Hoye, A, Kingston, D, Sarkar, D, Negahban, A, Webster, J, Wyatt, N, Muir, S, Cummings, M, Mackenzie, I, Senior, R, Capps, N, Fotherby, K, Mcintyre, H, Aldegather, J, Dixon, L, Saksena, R, Butler, R, Ramstad, D, Pierpont, B, Levinson, D, Mohammed, A, Haddad, T, Goel, A, Dave, K, Haught, Wh, Desire, A, Hershon, K, Napoli, M, Tami, L, Rothschild, R, Khurana, S, Gupta, D, Cheung, D, Hearne, S, Grubb, S, Miller, A, Baird, I, Marcus, A, Srivastava, S, Forgosh, L, Fritz, R, Mays, M, Bertolet, B, Reddy, J, Khan, M, Nakhle, S, Dill, S, Fishbein, G, Khan, B, Marais, H, Reschak, M, Malone, M, Nadar, V, Whitney, R, Reichman, A, Reyes, H, El Shahawy, M, Rabinowitz, A, Weinstein, D, Farhat, N, Onyema, D, Potu, R, Runquist, L, Barnum, O, Crater, T, Fialkow, J, Shah, A, Thompson, C, Wiseman, A, Doyle, T, Henderson, D, Herzog, W, Schnitzler, R, Carr, K, Davis, M, Nagajothi, N, Olsen, S, Rogers, W, Rubino, J, Singh, I, Tarleton, G, Bhagwat, R, Clardy, D, Jardula, M, Robinson, J, Torres, M, Vijay, N, Farris, N, Lillo, J, Moriarty, P, Recknor, C, Berlacher, P, Christensen, T, Gabra, N, Issa, M, Janik, M, Lawless, A, Molter, D, Stout, E, Brezina, B, Claxton, E, Linsky, R, Poock, J, Remler, R, Roseman, H, Schramm, E, Al-Joundi, T, Amin, J, Hitchcock, J, Isserman, S, Kirstein, J, Rider, J, Shalek, M, Sherman, H, Bernstein, M, Chandra, L, Hatharasinghe, R, Ibrahim, H, Iteld, B, Linzmeyer, K, Seaton, B, Zeig, S, Christofides, E, Dunbar, R, Griffin, S, Kohli, N, Koren, M, Pharr, W, Purdy, D, Spencer, R, Yeoman, G, Banerjee, S, Cheek, Hb, Engel, E, Hamroff, G, Huling, R, Kozlowski, L, Levin, P, Makam, S, Meengs, M, Bhushan, R, Erickson, B, Herman, L, Lo, E, Mcdowell, E, Mcgrew, F, Miller, M, Ord, J, Webel, R, Wilhoit, G, Wise, J, Yang, E, Budoff, M, Collins, J, Dauber, I, Dobkin, L, Focil, A, Gandy, W, Pasquini, J, Ramos, M, Rodriguez, D, Rosenson, R, Sanford, K, Schlau, A, Snyder, B, Stonesifer, L, Tang, A, De Souza, J, Elam, M III, French, J, Guyton, J, Hage Korban, E, Kereiakes, D, King, M, Loh, I, Navarro, J, Simons, R, Tobin, T, Younis, L, Aboufakher, R, Baldari, D, Ballantyne, C, Broughton, R, Eaton, C, Johnston, J, Simon, W, Thomson, S, Vora, K, Youngman, D, Alzohaili, O, Auerbach, E, Brown, C, Burrough, B, Chen, Y, Gilpatrick, M, Landzberg, J, Mitchell, C, Rice, L, Rubenfire, M, Sofley, Cw, Strobl, D, Atassi, K, Davila, W, Diogo, J, Fagan, T, Joffe, I, Krishna, J, Osea, E, Penny, W, Rowe, W, Shapiro, M, Welker, J, Benton, R, Dobratz, D, Fortuin, F, Graham, J, Henry, B, Kusnick, B, Lutskiy, M, Mcrae, A, Saway, W, Scott, J, Shah, M, Weinberg, B, Zarich, S, Acheatel, R, Case, C, Earl, J, Fernandez, S, Giugliano, G, Handelsman, Y, Hermany, P, Holder, S, Kashyap, M, Khan, A, Lader, E, Peniston, J, Raoof, T, Sacco, J, Shore, K, Spriggs, D, Stringam, S, Tahirkheli, N, Delgado, E, Derian, W, Greenwald, J, Harris, M, Jackson, R, Marhefka, G, Mcelveen, W, Mooss, A, Morris, P, Murray, J, Pearlstein, P, Raisinghani, A, Rezkalla, S, Sakhrani, L, Schreibman, D, Shaoulian, E, Steinsapir, J, Yataco, A, De La Cruz, A, Fredrick, M, Goldenberg, E, Lee, D, Mccullum, K, Mclellan, B, Stephens, L, Wilson, S, Alfieri, A, Mandviwala, M, Orourke, D, Samal, A, Schmedtje, J, Waxman, F, Carhart, R, Clements, B, Dyke, C, Ghali, J, Gruberg, L, Hack, T, Jehle, A, Pogue, B, Schooley, C, Shifrin, G., National Institute for Health Research, Amgen Inc, University of Zurich, Sabatine, Marc S, Sabatine, M, Giugliano, R, Keech, A, Honarpour, N, Wiviott, S, Murphy, S, Kuder, J, Wang, H, Liu, T, Wasserman, S, Sever, P, Pedersen, T, Fish, M, Abrahamsen, T, Im, K, Kanevsky, E, Bonaca, M, Lira Pineda, A, Hanlon, K, Knusel, B, Somaratne, R, Kurtz, C, Scott, R, Accini Mendoza, J, Amerena, J, Badariene, J, Burgess, L, Ceska, R, Charng, M, Choi, D, Cobos, J, Dan, G, De Ferrari, G, Deedwania, P, Chopra, V, Erglis, A, Ezhov, M, Ferreira, J, Filipova, S, Gaciong, Z, Pasierski, T, Georgiev, B, Gonzalez-Galvez, G, Gouni-Berthold, I, Schaufele, T, Hirayama, A, Huber, K, Rammer, M, Kjaerulf Jensen, H, Wermuth, S, Jiang, L, Jukema, J, Kraydashenko, O, Leiter, L, Lewis, B, Lopez-Miranda, J, Lorenzatti, A, Mach, F, Mcadam, B, Nilsson, L, Olsson, A, Rallidis, L, Rogelio, G, Kerr Saraiva, J, Scheen, A, Schiele, F, Connolly, D, Siu, C, Tay, L, Thorgeirsson, G, Tikkanen, M, Tokgozoglu, S, Toth, K, Viigimaa, M, Wan Ahmad, W, Hennekens, C, Andreotti, F, Baigent, C, Brown, W, Davis, B, Newcomer, J, Wood, S, Larosa, J, Ansell, B, Lowe, C, Zahn, L, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Mackinnon, I, Vogel, D, Leon de la Fuente, R, Perna, E, Amuchastegui, M, Pacora, F, Hershson, A, Blumberg, E, Glenny, J, Colombo, H, Cuadrado, J, Nicolosi, L, Rojas, C, Ulla, M, Hasbani, E, Cuneo, C, Lopez Santi, R, Sanabria, H, Hrabar, A, Lozada, A, Begg, A, Lehman, S, Wittert, G, Juergens, C, Kostner, K, Beltrame, J, Simpson, R, Sinhal, A, Adams, M, Kritharides, L, Roberts Thomson, P, Cross, D, Thompson, P, Van Gaal, W, Cox, N, Farshid, A, Hammett, C, Garrahy, P, Prasan, A, Horrigan, M, Ebenbichler, C, Hanusch, U, Prager, R, Schernthaner, G, Luger, A, Siostrzonek, P, Toplak, H, Bergler-Klein, J, Paulweber, B, Sinzinger, H, Buysschaert, I, Thoeng, J, Vandekerckhove, H, Catez, E, Verheye, S, Descamps, O, Hoffer, E, Wollaert, B, Chenu, P, van de Borne, P, De Meulemeester, M, Friart, A, Charlier, F, De Raedt, H, Rietzschel, E, Roelandt, R, Lalmand, J, Tavares Russo, L, Reis, G, Duarte Barbosa, E, Vidotti, M, Fernandes Manenti, E, Dutra, O, Leaes, P, Rech, R, Bertolim Precoma, D, Nicolau, J, Amoedo, R, Eliaschewitz, F, Pereira, A, Kurtz Lisboa, H, Soares Piegas, L, Cunha Borges, J, Ferreira Rossi, P, Pimentel Filho, P, Bodanese, L, de Sa Cunha, R, Moura Jorge, J, Ardito, W, Barroso de Souza, W, Hissa, M, Izar, M, Manolova, A, Kitova, L, Kinova, E, Tzekova, M, Velchev, V, Tarnovska-Kadreva, R, Gotchev, D, Petrov, I, Raev, D, Trendafilova-Lazarova, D, Yotov, Y, Lazov, P, Rahimi, S, St Amour, E, Constance, C, Pesant, Y, Hess, A, Anderson, T, Sussex, B, Henein, S, Tsoukas, G, Pandey, A, Bergeron, J, Hart, R, Gosselin, G, Chehayeb, R, Hamet, P, Hartleib, M, Mukherjee, A, Halperin, F, Petrella, R, Bhargava, R, Lonn, E, Sabbah, E, Bata, I, Cha, J, Gaudet, D, Chapman, K, Murthy, D, Nigro, F, Rupka, D, Gossard, D, Gupta, M, Dowell, A, Mansour, S, Baass, A, Geadah, C, Huynh, T, Peterson, S, Poirier, P, Sabe-Affaki, G, Vertes, G, Crowley, D, Duchesne, L, Pincetti Jofre, C, Potthoff Cardenas, S, Conejeros Kindel, C, Saavedra Gajardo, V, Lanas Zanetti, F, Sepulveda Varela, P, Stockins Fernandez, B, Li, W, Li, D, Zhao, S, Li, Z, Wang, J, Yang, Y, Zhang, L, Yang, P, Zhang, X, Huang, H, Xue, L, Zheng, Z, Huang, W, Dai, H, Su, H, Zeng, X, Zheng, Y, Tang, Y, Yao, Z, Sun, Y, Du, Y, Ge, Z, Yan, J, Chen, X, Liu, F, Pei, H, Yang, X, Cui, H, Gu, Y, Yang, Z, Li, J, Lian, Y, Cui, Y, Wang, D, Jiang, J, Li, X, Chen, J, Mo, Z, Xu, P, He, Y, Zhou, C, Qu, P, Zhu, Y, Liu, Y, Shen, X, Gao, X, Terront Lozano, M, Moncada Corredor, M, Hernandez Triana, E, Botero Lopez, R, Coronel Arroyo, J, Quintero Baiz, A, Sanchez Vallejo, G, Arana Londono, C, Molina de Salazar, D, Castellanos Bueno, R, Manzur Jattin, F, Cure Cure, C, Sotomayor Herazo, A, Spinar, J, Hala, T, Machkova, M, Klimsa, Z, Polasek, R, Jerabek, O, Kazdera, P, Pozdisek, Z, Vaclavik, J, Frana, P, Elbl, L, Kucera, D, Kryza, R, Malecha, J, Reichert, P, Sochor, K, Ludka, O, Kellnerova, I, Peterka, K, Zidkova, E, Cech, V, Brabec, T, Fiserova, N, Kvasnicka, J, Rosolova, H, Nemecek, E, Adamkova, V, Dunaj, M, Pojsl, S, Cepelak, M, Podpera, I, Kuchar, L, Rysava, D, Burianova, H, Spinarova, L, Skrobakova, J, Charvat, J, Homza, M, Zemanek, J, Koleckar, P, Karen, I, Krupicka, J, Blaha, V, Matuska, J, Brotanek, J, Cifkova, R, Kuchar, R, Vomacka, Z, Kosek, Z, Hulinsky, V, Krejcova, H, Kuchar, J, Jelinek, Z, Jelinek, P, Markdanner Lindgren, L, Saetre Lihn, A, Korsgaard Thomsen, K, Bronnum-Schou, J, Nielsen, H, Nielsen, T, Egstrup, K, Klausen, I, Mickley, H, Hove, J, Jeppesen, J, Melchior, T, Schmidt, E, Valter, I, Rosenthal, A, Kaik, J, Kork, A, Alt, I, Strand, J, Nieminen, S, Kahri, J, Suomi, J, Nyman, K, Strandberg, T, Piippo, T, Savolainen, M, Vikman, S, Pucheu, Y, Cariou, B, Henry, P, Ferrari, E, Montalescot, G, Ferrieres, J, Roubille, F, Bonnet, B, Angoulvant, D, Range, G, Bammert, A, Delarche, N, Mariat, C, Cayla, G, Durlach, V, Coisne, D, Paillard, F, Rouzier, R, Goralski, M, Khanoyan, P, Cottin, Y, Ziegler, O, Khalife, K, Le Corvoisier, P, Motreff, P, Spaulding, C, Vanbelle, E, Bourhaial, H, Opitz, C, Kahrmann, G, Contzen, C, Appel, K, Schenkenberger, I, Rinke, A, Trenk, D, Maus, O, Karakas, M, Hanefeld, M, Darius, H, Hetzel, G, Munzel, T, Wohrle, J, Stawowy, P, Marten, I, Isermann, B, Kast, P, Vorpahl, M, Bosiljanoff, P, Hengstenberg, C, Kassner, U, Salbach, P, Fischer, M, Steiner, S, Wagner, S, Kraatz, U, von Hodenberg, E, Weyland, K, Mantas, I, Tziakas, D, Bousboulas, S, Patsilinakos, S, Mertzanos, G, Panagoulis, C, Bilianou, H, Skoumas, I, Elisaf, M, Manolis, A, Moschos, N, Kochiadakis, G, Ntaios, G, Richter, D, Athyros, V, Kolovou, G, Danias, P, Melidonis, A, Fan, K, Siu, S, Hornyik, A, Lakatos, F, Zilahi, Z, Nagy, K, Laszlo, Z, Peterfai, E, Lupkovics, G, Andreka, P, Merkely, B, Herczeg, B, Piros, G, Salamon, C, Mark, L, Papp, A, Szakal, I, Edes, I, Mohacsi, A, Tomcsanyi, J, Hajko, E, Nagy, A, Papp, E, Kiss, R, Karadi, I, Sigurdsson, A, Jain, A, Pai, R, Kothiwale, V, Kulkarni, G, Mahajan, A, Aggarwal, S, Mehta, V, Rajadhyaksha, G, Joshi, A, Khandait, V, Parmar, M, Tyagi, S, Airody Govinda, R, Dwivedi, S, Parikh, K, Pothineni, R, Solanki, B, O'Donnell, M, Crean, P, Barton, J, Shechter, M, Shotan, A, Klutstein, M, Chorin, E, Gavish, D, Kracoff, O, Atar, S, Rigler, S, Hasin, Y, Schiff, E, Merlini, P, Rapezzi, C, Pirro, M, Gonnelli, S, Floresta, A, Mennuni, M, Ardissino, D, Senni, M, Marenzi, G, Marcucci, R, Sampietro, T, Cosmi, F, Perrone Filardi, P, De Caterina, R, Fedele, F, Moretti, L, Biasucci, L, Ferri, C, Go, Y, Kiyosue, A, Higashi, Y, Tokunaga, T, Kawasaki, T, Sakagami, S, Namba, S, Saku, K, Oku, K, Arakawa, T, Iida, H, Nakamura, Y, Yamamoto, K, Hata, Y, Katsuda, Y, Koga, Y, Shimizu, M, Uehara, H, Kajiyama, S, Okamoto, H, Shinozaki, T, Fujino, Y, Funazaki, T, Higa, N, Kaigawa, K, Koike, A, Nakane, H, Sato, K, Satoh, Y, Shirasawa, K, Sugino, H, Tanabe, J, Uemura, O, Yoshimichi, G, Akai, A, Himeno, H, Inage, T, Inoko, M, Kadokami, T, Noguchi, Y, Yamashita, K, Yasumura, Y, Yuge, M, Hosokawa, S, Kawamitsu, K, Kozuma, K, Matsuo, H, Nakashima, E, Okada, M, Wada, A, Yokoya, K, Iwade, K, Kawabata, K, Tanno, H, Ako, J, Fujita, H, Izumiya, Y, Kanno, M, Nunohiro, T, Ohmura, H, Ueno, T, Kakurina, N, Jasinkevica, I, Stukena, I, Veze, I, Eglite, R, Teterovska, D, Sime, I, Strazdiene, V, Venceviciene, L, Gustiene, O, Radzeviciene-Jurgute, R, Kucinskiene, A, Maskon, O, Lee, C, Erng, T, Gan, H, Mohamed Yusof, A, Ramanathan, G, Liew, H, Lopez Alvarado, A, Nevarez Ruiz, L, De los Rios Ibarra, M, Bazzoni Ruiz, A, Ramos Lopez, G, Llamas Esperon, G, De la Pena Topete, G, Violante Ortiz, R, Illescas Diaz, J, Leon Gonzalez, S, Sanchez Diaz, C, Mendez Machado, G, Venegas Carrillo, L, Aldrete Velasco, J, Cardona Munoz, E, Leiva Pons, J, Perez Alva, J, van der Zwaan, C, Oomen, A, van de Wal, R, Magro, M, Boswijk, D, Janus, C, Groutars, R, Tonino, W, Cornel, J, Oude Ophuis, A, Troquay, R, Liem, A, Westendorp, I, Van Hessen, M, Lok, D, De Nooijer, C, Den Hartog, F, Van Beek, E, Bendermacher, P, Jansen, R, Romer, T, Rensing, B, Hersbach, F, Herrman, J, Ladyjanskaia, G, Karalis, I, Linssen, G, Bokern, M, Visman, A, Kooij, A, Monajemi, H, Lieverse, A, Baker, J, Tie, S, Risberg, K, Hysing, J, Hoivik, H, Norheim, P, Solnor, L, Hovland, A, Kjaernli, T, Jocson, G, Coching, R, Batalla, E, Go, A, Habaluyas, R, Barcinas, R, Sy, R, Estepar, R, Germar, A, Trebacz, J, Szymkowiak, K, Wnetrzak-Michalska, R, Kopaczewski, J, Przekwas-Jaruchowska, M, Kania, G, Zabowka, M, Mirek-Bryniarska, E, Dabrowska, M, Napora, P, Konieczny, M, Spyra, J, Lysek, R, Pijanowski, Z, Grzegorzewski, B, Bednarkiewicz, Z, Kinasz, L, Antkowiak-Piatyszek, K, Stania, K, Szpajer, M, Staneta, P, Skonieczny, G, Ksiezycka-Majczynska, E, Blicharski, T, Piepiorka, M, Wozakowska-Kaplon, B, Zechowicz, T, Ilkowski, J, Lubiszewska, B, Hiczkiewicz, J, Wierzbicka, K, Kosior, D, Garbocz, P, Kubica, J, Raczak, G, Wozniak, I, Cygler, J, Kramarczuk, E, Bystryk, L, Pentela-Nowicka, J, Dabrowski, M, Podolec, P, Zieba, B, Mosiewicz, J, Dubaniewicz, W, Banach, M, Tyszecka, G, Lepich, T, Rychlewska-Hanczewska, A, Guzik, T, Monteiro, P, Pereira, H, Oliveira, L, Matos, P, Soares Goncalves, S, Leitao, A, Vasco Salgado, A, Timoteo, A, Pintilei, E, Badila, E, Militaru, C, Tudoran, M, Arsenescu-Georgescu, C, Mitu, F, Zdrenghea, D, Lighezan, D, Teodorescu, I, Popescu, M, Coman, I, Vintila, M, Vishnevsky, A, Lukyanov, Y, Blokhin, A, Kostenko, V, Shvarts, Y, Markov, V, Motylev, I, Dronov, D, Sherenkov, A, Barbarash, O, Shutemova, E, Bolshakova, O, Kobalava, Z, Voevoda, M, Treshkur, T, Zrazhevskiy, K, Pimenov, L, Solovev, O, Tarasov, N, Arkhipov, M, Freidlin, M, Shalaev, S, Yakhontova, P, Shustov, S, Goloshchekin, B, Panov, A, Bart, B, Bubnova, M, Gordeev, I, Osipova, I, Tereshenko, S, Solovieva, E, Meshkov, A, Zateyshchikov, D, Tan, J, Subramaniam, T, Pella, D, Fulop, P, Antalik, L, Dzupina, A, Banikova, A, Sosovec, D, Urgeova, L, Mazur, J, Hranai, M, Banik, M, Vinanska, D, Lennerova, J, Kovar, F, Pastrnakova, E, Uhliar, R, Blasko, P, Gonsorcik, J, Lukacova, J, Oriesek, R, Hatalova, K, du Toit, M, Ebrahim, I, Vawda, G, Lipschitz, S, Blignaut, S, Engelbrecht, J, Coetzer, T, Pretorius, M, Urbach, D, Badat, A, Pillay, S, Van Zyl, L, Abelson, M, van der Walt, E, Moodley, R, Jacovides, A, Oosthuysen, W, Klug, E, Lottering, H, Kok, J, Saaiman, J, Dawood, S, De Jong, D, Kapp, C, Makotoko, E, Bayat, J, Sarvan, M, Vally, T, Stapelberg, A, Kim, M, Bae, J, Cho, Y, Kim, S, Han, K, Her, S, Kim, B, Lee, S, Hong, B, Kim, W, Rha, S, Jeong, M, Shin, G, Vida Gutierrez, M, Valdes Chavarri, M, Pinto Sala, X, Gonzalez Juanatey, J, Civeira Murillo, F, Zamorano Gomez, J, Lekuona Goya, I, Iniguez Romo, A, Cordero Fort, A, Ascaso Gimilio, J, Millan Nunez-Cortes, J, Lindholm, C, Soderberg, S, Suutari, A, Berglund, S, Mooe, T, Kusiak, D, Bandh, S, Dahlen, G, Olsson, S, Witt, N, Tyden, P, Johansson, P, Cizinsky, S, Falck, G, Pettersson, S, Rasmanis, G, Ostergren, J, Moccetti, T, Beer, H, Eberli, F, Krahenbuhl, S, Linka, A, Ackermann, D, Michel, P, Yeh, H, Tsai, C, Wu, C, Hsia, C, Juang, J, Hsieh, I, Lai, W, Huang, C, Hsieh, Y, Sahin, T, Duzenli, M, Yigit, Z, Demir, M, Yilmaz, M, Muderrisoglu, I, Kirma, C, Ercan, E, Kayikcioglu, L, Balbay, Y, Lymar, I, Kulynych, O, Prokhorov, O, Karpenko, O, Kraіz, I, Vakaliuk, I, Stanislavchuk, M, Korzh, O, Rudyk, I, Zhurba, S, Svishchenko, Y, Tseluyko, V, Gyrina, O, Reshotko, D, Kopytsya, M, Volkov, V, Myshanych, G, Rebrov, B, Rishko, M, Rudenko, L, Shatylo, V, Parkhomenko, O, Yena, L, Golovchenko, O, Sorokina, I, Malynovsky, Y, Ivan, P, Blagden, M, Dear, H, Mathew, A, Lagocki, S, Kondagunta, V, Ahsan, A, Mckinnon, C, Douglas, F, Thom, S, Fiore, G, Caulfield, M, Lynch, M, Thomas, H, Bain, S, Hall, A, Mcnally, D, Fisher, M, Keeling, P, Al-Bahrani, A, Lip, G, Ellery, A, Purohit, J, Travill, C, Cappuccio, F, Davis, G, Gaunt, R, Adlam, D, Asamoah, N, Jaafar, F, Mccormack, T, Jupp, B, Pye, M, Ainsworth, P, Chauhan, A, Paul, N, Fairlie, H, Fox, C, Muzulu, S, Trevelyan, J, Aggarwal, R, Issa, B, Saravanan, P, Cruickshank, K, Gorog, D, Heller, S, Newby, D, Nicolson, A, Hare, P, Donnelly, P, Rutherfurd, S, de Belder, M, Finlayson, J, Harvey, J, Hoye, A, Kingston, D, Sarkar, D, Negahban, A, Webster, J, Wyatt, N, Muir, S, Cummings, M, Mackenzie, I, Senior, R, Capps, N, Fotherby, K, Mcintyre, H, Aldegather, J, Dixon, L, Saksena, R, Butler, R, Ramstad, D, Pierpont, B, Levinson, D, Mohammed, A, Haddad, T, Goel, A, Dave, K, Haught, W, Desire, A, Hershon, K, Napoli, M, Tami, L, Rothschild, R, Khurana, S, Gupta, D, Cheung, D, Hearne, S, Grubb, S, Miller, A, Baird, I, Marcus, A, Srivastava, S, Forgosh, L, Fritz, R, Mays, M, Bertolet, B, Reddy, J, Khan, M, Nakhle, S, Dill, S, Fishbein, G, Khan, B, Marais, H, Reschak, M, Malone, M, Nadar, V, Whitney, R, Reichman, A, Reyes, H, El Shahawy, M, Rabinowitz, A, Weinstein, D, Farhat, N, Onyema, D, Potu, R, Runquist, L, Barnum, O, Crater, T, Fialkow, J, Shah, A, Thompson, C, Wiseman, A, Doyle, T, Henderson, D, Herzog, W, Schnitzler, R, Carr, K, Davis, M, Nagajothi, N, Olsen, S, Rogers, W, Rubino, J, Singh, I, Tarleton, G, Bhagwat, R, Clardy, D, Jardula, M, Robinson, J, Torres, M, Vijay, N, Farris, N, Lillo, J, Moriarty, P, Recknor, C, Berlacher, P, Christensen, T, Gabra, N, Issa, M, Janik, M, Lawless, A, Molter, D, Stout, E, Brezina, B, Claxton, E, Linsky, R, Poock, J, Remler, R, Roseman, H, Schramm, E, Al-Joundi, T, Amin, J, Hitchcock, J, Isserman, S, Kirstein, J, Rider, J, Shalek, M, Sherman, H, Bernstein, M, Chandra, L, Hatharasinghe, R, Ibrahim, H, Iteld, B, Linzmeyer, K, Seaton, B, Zeig, S, Christofides, E, Dunbar, R, Griffin, S, Kohli, N, Koren, M, Pharr, W, Purdy, D, Spencer, R, Yeoman, G, Banerjee, S, Cheek, H, Engel, E, Hamroff, G, Huling, R, Kozlowski, L, Levin, P, Makam, S, Meengs, M, Bhushan, R, Erickson, B, Herman, L, Lo, E, Mcdowell, E, Mcgrew, F, Miller, M, Ord, J, Webel, R, Wilhoit, G, Wise, J, Yang, E, Budoff, M, Collins, J, Dauber, I, Dobkin, L, Focil, A, Gandy, W, Pasquini, J, Ramos, M, Rodriguez, D, Rosenson, R, Sanford, K, Schlau, A, Snyder, B, Stonesifer, L, Tang, A, De Souza, J, Elam, M, French, J, Guyton, J, Hage Korban, E, Kereiakes, D, King, M, Loh, I, Navarro, J, Simons, R, Tobin, T, Younis, L, Aboufakher, R, Baldari, D, Ballantyne, C, Broughton, R, Eaton, C, Johnston, J, Simon, W, Thomson, S, Vora, K, Youngman, D, Alzohaili, O, Auerbach, E, Brown, C, Burrough, B, Chen, Y, Gilpatrick, M, Landzberg, J, Mitchell, C, Rice, L, Rubenfire, M, Sofley, C, Strobl, D, Atassi, K, Davila, W, Diogo, J, Fagan, T, Joffe, I, Krishna, J, Osea, E, Penny, W, Rowe, W, Shapiro, M, Welker, J, Benton, R, Dobratz, D, Fortuin, F, Graham, J, Henry, B, Kusnick, B, Lutskiy, M, Mcrae, A, Saway, W, Scott, J, Shah, M, Weinberg, B, Zarich, S, Acheatel, R, Case, C, Earl, J, Fernandez, S, Giugliano, G, Handelsman, Y, Hermany, P, Holder, S, Kashyap, M, Khan, A, Lader, E, Peniston, J, Raoof, T, Sacco, J, Shore, K, Spriggs, D, Stringam, S, Tahirkheli, N, Delgado, E, Derian, W, Greenwald, J, Harris, M, Jackson, R, Marhefka, G, Mcelveen, W, Mooss, A, Morris, P, Murray, J, Pearlstein, P, Raisinghani, A, Rezkalla, S, Sakhrani, L, Schreibman, D, Shaoulian, E, Steinsapir, J, Yataco, A, De La Cruz, A, Fredrick, M, Goldenberg, E, Lee, D, Mccullum, K, Mclellan, B, Stephens, L, Wilson, S, Alfieri, A, Mandviwala, M, Orourke, D, Samal, A, Schmedtje, J, Waxman, F, Carhart, R, Clements, B, Dyke, C, Ghali, J, Gruberg, L, Hack, T, Jehle, A, Pogue, B, Schooley, C, and Shifrin, G
- Subjects
Male ,STATIN THERAPY ,2700 General Medicine ,Disease ,Cardiovascular ,PLACEBO-CONTROLLED TRIAL ,Gastroenterology ,0302 clinical medicine ,Anticholesteremic Agent ,Medicine ,Myocardial infarction ,11 Medical and Health Sciences ,ddc:616 ,Incidence ,Antibodies, Monoclonal ,General Medicine ,Cholesterol ,Cardiovascular Diseases ,Monoclonal ,Drug Therapy, Combination ,Proprotein Convertase 9 ,Antibody ,Aged ,Anticholesteremic Agents ,Atherosclerosis ,Cholesterol, LDL ,Double-Blind Method ,Female ,Follow-Up Studies ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Hypercholesterolemia ,Least-Squares Analysis ,Middle Aged ,Medicine (all) ,REDUCING LIPIDS ,Human ,medicine.medical_specialty ,Evinacumab ,Clinical Trials and Supportive Activities ,PCSK9 INHIBITION ,Follow-Up Studie ,LDL ,03 medical and health sciences ,Drug Therapy ,Clinical Research ,LDL-C ,Least-Squares Analysi ,Science & Technology ,Unstable angina ,PCSK9 ,medicine.disease ,chemistry ,Clinical Biochemistry ,030204 cardiovascular system & hematology ,Bococizumab ,FOURIER Steering Committee and Investigators ,Medical and Health Sciences ,chemistry.chemical_compound ,Antibodies monoclonal ,Cardiovascular Disease ,030212 general & internal medicine ,Stroke ,Humanized ,RISK ,biology ,PCSK9 Inhibitors ,10051 Rheumatology Clinic and Institute of Physical Medicine ,Heart Disease ,Atherosclerosi ,6.1 Pharmaceuticals ,Combination ,Cardiology ,Life Sciences & Biomedicine ,Antibodies, Monoclonal, Humanized ,EZETIMIBE ,610 Medicine & health ,Antibodies ,Medicine, General & Internal ,General & Internal Medicine ,Internal medicine ,CORONARY-HEART-DISEASE ,In patient ,Heart Disease - Coronary Heart Disease ,Alirocumab ,Ldl cholesterol ,business.industry ,Evaluation of treatments and therapeutic interventions ,Evolocumab ,Good Health and Well Being ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,biology.protein ,MODERATE ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,business - Abstract
Background Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin–kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. Methods We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. Results At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P
- Published
- 2017
44. Application of intelligent CNC in grinding
- Author
-
Rowe, W. Brian, Li, Y., Mills, B., and Allanson, D.R.
- Subjects
Numerical control -- Technology application ,Artificial intelligence -- Usage ,Grinding and polishing -- Technology application - Published
- 1996
45. The BABAR detector
- Author
-
Aubert, B, Bazan, A, Boucham, A, Boutigny, D, De Bonis, I, Favier, J, Gaillard, JM, Jeremie, A, Karyotakis, Y, Le Flour, T, Lees, JP, Karcher, A, Tinslay, J, Gabriel, TA, Handler, T, Heck, J, Meyer, WT, Iwasaki, M, Sinev, NB, Dubois-Felsmann, GP, Gill, MS, Olsen, J, Steinke, M, Caracciolo, R, Colecchia, F, Dal Corso, F, Galeazzi, F, Marzolla, M, Antohin, EI, Rosenberg, EI, Kerth, LT, Michelon, G, Hernikl, C, Spaan, B, Morandin, M, Posocco, M, Matricon, P, Dvoretskii, A, Rotondo, M, Santi, S, Simonetto, F, Stroili, R, Albert, JN, Roberts, DA, Torassa, E, Robutti, E, Voci, C, Blinov, VE, Bailly, P, Kipnis, I, de Freitas, PM, Benayoun, M, Hanson, JE, Briand, H, Schieck, JR, Chauveau, J, Cottingham, WN, McFall, JD, David, P, De la Vaissiere, C, Del Buono, L, Genat, JF, Hamon, O, Bukin, AD, Renard, C, Blaylock, G, Leruste, P, Le Diberder, F, Hitlin, DG, Aspinwall, ML, Beigbeder, C, Kluth, S, Lebbolo, H, Lory, J, Martin, L, Martinez-Vidal, F, Brochard, F, Roos, L, Stark, J, Roussot, E, Versille, S, Bowerman, DA, Bukin, DA, Benkebil, M, Zhang, B, Deppermann, T, Manfredi, PF, Flood, K, Ratti, L, Kral, JF, Re, V, Speziali, V, Frank, ED, Dauncey, PD, T'Jampens, S, Gladney, L, Futterschneider, H, Guo, QH, Hertzbach, SS, Panetta, JH, Buzykaev, AR, Kolomensky, YG, Angelini, C, Batignani, G, Bettarini, S, Eschrich, I, Bondioli, M, Lafever, R, Thiebaux, C, Thiessen, D, Qi, ND, Bosi, F, Carpinelli, M, Forti, F, Gaddi, A, Gagliardi, D, Wang, P, Gunawardane, NJW, Dubrovin, MS, Giorgi, MA, Crawley, HB, Lusiani, A, Mammini, P, Breton, D, Vasileiadis, G, Morganti, M, Morsani, F, LeClerc, C, Neri, N, Martin, R, Profeti, A, Kay, M, Paoloni, E, Metzler, S, Raffaelli, F, Golubev, VB, Cizeron, R, Rama, M, Verderi, M, Rizzo, G, Sandrelli, F, Schalk, T, Rong, G, Simi, G, Triggiani, G, Haire, M, Levi, ME, Judd, D, Oyang, J, Dardin, S, Paick, K, Turnbull, L, Amerman, L, Kofler, R, Nash, JA, Ivanchenko, VN, Wagoner, DE, Albert, J, Bula, C, Kelsey, MH, Lu, C, McDonald, KT, Du, S, Miftakov, V, Lin, CS, Porter, FC, Price, DR, Lewis, SA, Dorfan, DE, Sands, B, Schaffner, SF, Kolachev, GM, Smith, AJS, Tumanov, A, Varnes, EW, Willocq, S, Grosdidier, G, Bronzini, F, Santroni, A, Buccheri, A, Bulfon, C, Ryd, A, Anjomshoaa, A, Cavoto, G, del Re, D, Lionberger, C, Wittlin, J, Ferrarotto, F, Tisserand, V, Hast, C, Schmuecker, H, Ferroni, F, Fratini, K, Lamanna, E, Leonardi, E, Mazzoni, MA, Lieunard, S, Brau, B, Samuel, A, Morganti, S, Piredda, G, Tehrani, FS, Sanders, P, Hocker, A, Serra, M, Liu, T, Korol, AA, Voena, C, Jacobsen, RG, Waldi, R, Jacques, PF, Bernet, R, Kalelkar, M, Weaver, M, Smith, D, Plano, RJ, Lacker, HM, Adye, T, Claxton, B, Cohen-Tanugi, J, Dowdell, J, Egede, U, Franek, B, Kravchenko, EA, Long, M, Di Lodovico, F, Wallom, D, Galagedera, S, Geddes, NI, De Groot, N, Cowan, R, Yang, S, Gopal, GP, Kay, J, Lidbury, J, Madani, S, Metcalfe, S, Goozen, FR, Markey, G, Muheim, F, Taylor, F, Mikhailov, SF, Kocian, ML, Olley, P, Luo, L, Zhu, RY, Watt, M, Xella, SM, Aleksan, R, Azzopardi, DE, Besson, P, McMahon, S, Bourgeois, P, Convert, P, Playfer, S, LePeltier, V, De Domenico, G, de Lesquen, A, Onuchin, AP, Emery, S, Koch, H, Back, JJ, Johnson, RP, Gaidot, A, Lynch, G, Ganzhur, SF, Georgette, Z, Gosset, L, Watson, AT, Swain, JE, Graffin, P, de Monchenault, GH, Herve, S, Yamamoto, RK, Dixon, P, Karolak, M, Salnikov, AA, Devmal, S, Kozanecki, W, Langer, M, London, GW, Lutz, AM, Luft, P, Falbo, M, Britton, DI, Marques, V, Harrison, PF, Mayer, B, Micout, P, Mols, JP, Mouly, JP, Penichot, Y, Geld, TL, Serednyakov, SI, Plaszczynski, S, Turri, M, Rolquin, J, Serfass, B, Schmitz, RE, Bozzi, C, Toussaint, JC, Usseglio, M, Mandelli, E, Vasseur, G, Yeche, C, Zito, M, Camanzi, B, Copty, N, Schune, MH, Zhu, YS, Bartoldus, R, Purohit, MV, Skovpen, YI, Dittongo, S, Yumiceva, FX, Adam, I, Adesanya, A, Fernholz, R, Anthony, PL, Aston, D, Marino, M, Trincaz-Duvoid, S, Newman-Coburn, D, Bartelt, J, Becla, J, Jayatilleke, S, Bell, R, Eisner, AM, Houde, M, Bloom, E, Telnov, VI, Boeheim, CT, Boyarski, AM, Boyce, RF, Beringer, J, Day, C, Briggs, D, Bulos, F, Burgess, W, Milek, M, Marks, K, Jayatilleke, SM, Folegani, M, Byers, B, Calderini, G, Chestnut, R, Potter, RJL, Yushkov, AN, Truong, K, Claus, R, Patel, PM, Convery, MR, Coombes, R, Cottrell, L, Coupal, DP, Coward, DH, Borgland, AW, Mancinelli, G, Shorthouse, HW, Craddock, WW, Matuk, C, Ferrag, S, Valassi, A, DeBarger, S, DeStaebler, H, Booth, J, Dorfan, J, Doser, M, Dunwoodie, W, Dusatko, JE, Williams, MI, Andress, JC, Muir, A, Ecklund, S, Meadows, BT, Wormser, G, Fieguth, TH, Freytag, DR, Glanzman, T, Meyer, AB, Godfrey, GL, Zachariadou, K, Vidal, PB, Trischuk, J, Haller, G, Hanushevsky, A, Piemontese, L, Harris, J, Krause, R, Hasan, A, Sokoloff, MD, Hee, C, Himel, T, Huffer, ME, Eckstein, P, Wilson, FF, Hung, T, Innes, WR, Minor, R, Lankford, AJ, Ramusino, AC, Alford, O, Jessop, C, Kawahara, H, Keller, L, Lanni, F, Bloom, P, Cowan, G, King, ME, Klaisner, L, Krebs, HJ, Langenegger, U, Langeveld, W, Leith, DWGS, Dyce, N, Treadwell, E, Jared, RC, Louie, SK, Mandelkern, M, Gowdy, S, Mokhtarani, A, Luitz, S, Broomer, B, Luth, V, Lynch, HL, McDonald, J, Manzin, G, Palombo, F, Kroeger, W, Marsiske, H, Anulli, F, George, S, Mattison, T, McCulloch, M, McDougald, M, Pier, S, McShurley, D, Krug, J, Bauer, JM, Momayezi, M, Menke, S, Behne, D, Messner, R, Dignan, T, Baldini-Ferroli, R, Morii, M, Mount, R, Muller, DR, Walkowiak, W, Nelson, D, Nordby, M, Stoker, DP, Erdos, E, Bionta, RM, Green, MG, O'Grady, CP, Olavson, L, Nyman, M, Calcaterra, A, Booke, M, O'Neill, FG, Oxoby, G, Paolucci, P, Pavel, T, Perl, J, Schumm, BA, Bowman, J, Pertsova, M, Fahey, S, Harrison, TJ, Zioulas, G, Petrak, S, de Sangro, R, Putallaz, G, Raines, PE, Oddone, PJ, Ratcliff, BN, Wilden, L, Reif, R, Brigljevic, V, Cremaldi, L, Robertson, SH, Rochester, LS, Roodman, A, Ford, WT, Russel, JJ, Frey, A, Ahsan, A, Sapozhnikov, L, Kurup, A, Saxton, OH, Payne, DJ, Schietinger, T, Brooks, A, Schindler, RH, Ohnemus, J, Schwiening, J, Sciolla, G, Seeman, JT, Eigen, G, Falciai, D, Marker, CE, Kroeger, R, Serbo, VV, Shapiro, S, Arisaka, K, Dacosta, VA, Skarpass, K, Snyder, A, Soderstrom, E, Soha, A, Spanier, SM, Oshatz, D, Abrams, GS, McGrath, P, Stahl, A, Finocchiaro, G, Gaede, F, Stiles, P, Dow, SF, Su, D, Sullivan, MK, Buchanan, C, Talby, M, Clark, AR, Tanaka, HA, McMahon, TR, Va'vra, J, Wagner, SR, Wang, R, Patteri, P, Weber, T, Muller-Pfefferkorn, R, van Hoek, WC, Patton, S, Reep, M, Weinstein, AJR, White, JL, Salvatore, F, Wienands, U, Chun, S, Wisniewski, WJ, Young, CC, Yu, N, Barlow, NR, Fackler, O, Reidy, J, Burchat, PR, Cheng, CH, Johnson, DR, Scott, I, Kirkby, D, Meyer, TI, Pedrali-Noy, M, Roat, C, Henderson, R, Faccini, R, Sanders, DA, Khan, N, Fujino, D, Breon, AB, Berridge, S, Abe, K, Bugg, W, Cohn, H, Michael, AK, Hart, E, Weidemann, AW, Summers, DJ, Benninger, T, Izen, JM, Perazzo, A, Harper, M, Kitayama, I, Hamilton, R, Peruzzi, IM, Palano, A, Lou, XC, Turcotte, M, Arguin, JF, Bianchi, F, Nauenberg, U, Bona, M, Daudo, F, Di Girolamo, B, Lockman, WS, Vaitsas, G, Gamba, D, Grosso, P, Piccolo, M, Kadel, RW, Smol, A, Peters, C, MacFarlane, DB, Trapani, PP, Zanin, D, Olivas, A, Bosisio, L, Brown, D, Foster, B, Della Ricca, G, Wilder, M, Lanceri, L, Pompili, A, Xie, Y, Poropat, P, Prest, M, Rashevskaia, I, Vallazza, E, Prell, SA, Gritsan, AV, Pope, W, Sloane, RJ, Lange, D, Kunze, M, Vuagnin, G, Panvini, RS, Brown, C, Zallo, A, De Silva, A, Kowalewski, R, Pitman, D, Behr, L, Beaulieu, M, Roney, JM, Band, HR, Mugge, M, Charles, E, Rahatlou, S, Park, H, Dasu, S, Pripstein, M, Bagnasco, S, Elmer, P, Martin, JP, Seiden, A, Johnson, JR, Nielsen, J, Orejudos, W, O'Connor, TG, Pan, Y, Prepost, R, Scott, IJ, Walsh, J, Rankin, P, McKemey, AK, Raven, G, Davis, CL, Grillo, AA, Wu, SL, Yu, Z, Quarrie, DR, Olson, H, Zobernig, H, Moore, TB, Neal, H, Fischer, PA, BABAR Collaboration, Rasson, JE, Li, Y, Roe, NA, Roy, J, Buzzo, A, Romosan, A, Sharma, V, Ott, L, Ronan, MT, Fouque, G, Shelkov, VG, Stone, R, Strother, PD, Pavlovich, J, Telnov, AV, von der Lippe, H, Weber, TF, Wenzel, WA, Contri, R, Sen, S, Nief, JY, Abbott, B, Zizka, G, Bright-Thomas, PG, Burke, S, Allison, J, Hawkes, CM, Kirk, A, Knowles, DJ, O'Neale, SW, Callahan, D, Seitz, R, Campagnari, C, Crosetti, G, Parker, E, Dahmes, B, Reinertsen, PL, Barlow, RJ, Hale, D, Chen, GP, Hart, PA, Kuznetsova, N, Taras, P, Kyre, S, Levy, SL, Long, O, Lu, A, Pedrotti, B, Fabbricatore, P, Clark, PJ, May, J, Richman, JD, Smith, JG, Woch, A, Verkerke, W, Witherell, M, Chen, JC, Yellin, S, Wagner, DL, Blouw, J, Fan, Q, Boyd, JT, Harton, JL, Bhimji, W, Zacek, V, Krishnamurthy, M, Lewandowski, B, Soffer, A, Toki, WH, Warner, DW, Wilson, RJ, Zhang, J, Stugu, B, Fullwood, J, Roeben, M, Sadrozinski, H, Brandt, T, Brose, J, Farinon, S, Dahlinger, G, Dickopp, M, Peters, K, Dubitzky, RS, Brown, DN, Lo Vetere, M, Hearty, C, Nicholson, H, Macri, M, Pulliam, T, Minutoli, S, Grothe, M, Monge, MR, Musenich, R, Pallavicini, M, Parodi, R, Passaggio, S, Chevalier, N, Sutton, CS, Jackson, F, Pastore, FC, Patrignani, C, Shi, X, Button-Shafer, J, Pia, MG, Heusch, CA, Priano, C, Mass, A, van Bibber, K, Williams, DC, Wenaus, TJ, Bernard, D, Wright, DM, Schubert, KR, Wuest, CR, Yamamoto, B, Carroll, M, Cooke, P, Fry, JR, Rowe, W, Cartaro, C, Gaponenko, I, Gabathuler, E, Khan, A, Petitpas, P, Gamet, R, Schwierz, R, George, M, Spencer, EN, Lafferty, GD, Groysman, Y, Lamsa, J, Savvas, N, Mallik, U, Simopoulos, ET, Thompson, RJ, Weatherall, JH, Bard, R, Dallapiccola, C, Bonneaud, GR, McKenna, JA, Farbin, A, Kadyk, J, Watson, NK, Jawahery, A, Cochran, J, Lillard, V, Gastaldi, F, Cavallo, N, Robbe, P, De Nardo, G, Sutcliffe, P, Fabozzi, F, Gatto, C, Lista, L, Piccolo, D, Sciacca, C, McKay, R, Chen, E, Cason, NM, DeWitt, J, LoSecco, JM, Touramanis, C, Alsmiller, JRG, Biophysics Photosynthesis/Energy, (Astro)-Particles Physics, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), BABAR, Bosisio, Luciano, DELLA RICCA, Giuseppe, Lanceri, Livio, Poropat, Paolo, Vitale, Lorenzo, Aubert B., Bazan A., Boucham A., Boutigny D., De Bonis I., Favier J., Gaillard J.-M., Jeremie A., Karyotakis Y., Le Flour T., Lees J.P., Lieunard S., Petitpas P., Robbe P., Tisserand V., Zachariadou K., Palano A., Chen G.P., Chen J.C., Qi N.D., Rong G., Wang P., Zhu Y.S., Eigen G., Reinertsen P.L., Stugu B., Abbott B., Abrams G.S., Amerman L., Borgland A.W., Breon A.B., Brown D.N., Button-Shafer J., Clark A.R., Dardin S., Day C., Dow S.F., Fan Q., Gaponenko I., Gill M.S., Goozen F.R., Gowdy S.J., Gritsan A., Groysman Y., Hernikl C., Jacobsen R.G., Jared R.C., Kadel R.W., Kadyk J., Karcher A., Kerth L.T., Kipnis I., Kluth S., Kral J.F., Lafever R., LeClerc C., Levi M.E., Lewis S.A., Lionberger C., Liu T., Long M., Luo L., Lynch G., Luft P., Mandelli E., Marino M., Marks K., Matuk C., Meyer A.B., Minor R., Mokhtarani A., Momayezi M., Nyman M., Oddone P.J., Ohnemus J., Oshatz D., Patton S., Pedrali-Noy M., Perazzo A., Peters C., Pope W., Pripstein M., Quarrie D.R., Rasson J.E., Roe N.A., Romosan A., Ronan M.T., Shelkov V.G., Stone R., Strother P.D., Telnov A.V., von der Lippe H., Weber T.F., Wenzel W.A., Zizka G., Bright-Thomas P.G., Hawkes C.M., Kirk A., Knowles D.J., O'Neale S.W., Watson A.T., Watson N.K., Deppermann T., Koch H., Krug J., Kunze M., Lewandowski B., Peters K., Schmuecker H., Steinke M., Andress J.C., Barlow N.R., Bhimji W., Chevalier N., Clark P.J., Cottingham W.N., De Groot N., Dyce N., Foster B., Mass A., McFall J.D., Wallom D., Wilson F.F., Abe K., Hearty C., McKenna J.A., Thiessen D., Camanzi B., Harrisott T.J., McKemey A.K., Tinslay J., Antohin E.I., Blinov V.E., Bukin A.D., Bukin D.A., Buzykaev A.R., Dubrovin M.S., Golubev V.B., Ivanchenko V.N., Kolachev G.M., Korol A.A., Kravchenko E.A., Mikhailov S.F., Onuchin A.P., Salnikov A.A., Serednyakov S.I., Skovpen Yu.I., Telnov V.I., Yushkov A.N., Booth J., Lankford A.J., Mandelkern M., Pier S., Stoker D.P., Zioulas G., Ahsan A., Arisaka K., Buchanan C., Chun S., Faccini R., MacFarlane D.B., Prell S.A., Rahatlou Sh., Raven G., Sharma V., Burke S., Callahan D., Campagnari C., Dahmes B., Hale D., Hart P.A., Kuznetsova N., Kyre S., Levy S.L., Long O., Lu A., May J., Richman J.D., Verkerke W., Witherell M., Yellin S., Beringer J., DeWitt J., Dorfan D.E., Eisner A.M., Frey A., Grillo A.A., Grothe M., Heusch C.A., Johnson R.P., Kroeger W., Lockman W.S., Pulliam T., Rowe W., Sadrozinski H., Schalk T., Schmitz R.E., Schumm B.A., Seiden A., Spencer E.N., Turri M., Walkowiak W., Wilder M., Williams D.C., Chen E., Dubois-Felsmann G.P., Dvoretskii A., Hanson J.E., Hitlin D.G., Kolomensky Yu.G., Metzler S., Oyang J., Porter F.C., Ryd A., Samuel A., Weaver M., Yang S., Zhu R.Y., Devmal S., Geld T.L., Jayatilleke S., Jayatilleke S.M., Mancinelli G., Meadows B.T., Sokoloff M.D., Bloom P., Broomer B., Erdos E., Fahey S., Ford W.T., Gaede F., van Hoek W.C., Johnson D.R., Michael A.K., Nauenberg U., Olivas A., Park H., Rankin P., Roy J., Sen S., Smith J.G., Wagner D.L., Blouw J., Harton J.L., Krishnamurthy M., Soffer A., Toki W.H., Warner D.W., Wilson R.J., Zhang J., Brandt T., Brose J., Dahlinger G., Dickopp M., Dubitzky R.S., Eckstein P., Futterschneider H., Kocian M.L., Krause R., Muller-Pfefferkorn R., Schubert K.R., Schwierz R., Spaan B., Wilden L., Behr L., Bernard D., Bonneaud G.R., Brochard F., Cohen-Tanugi J., Ferrag S., Fouque G., Gastaldi F., Matricon P., Mora de Freitas P., Renard C., Rousso E., T'Jampens S., Thiebaux C., Vasileiadis G., Verderi M., Anjomshoaa A., Berne R., Di Lodovico F., Muheim F., Playfer S., Swain J.E., Falbo M., Bozzi C., Dittongo S., Folegani M., Piemontese L., Ramusino A.C., Treadwell E., Anulli F., Baldini-Ferroli R., Calcaterra A., de Sangro R., Falciai D., Finocchiaro G., Patteri P., Peruzzi I.M., Piccolo M., Xie Y., Zallo A., Bagnasco S., Buzzo A., Contri R., Crosetti G., Fabbricatore P., Farinon S., Lo Vetere M., Macri M., Minutoli S., Monge M.R., Musenich R., Pallavicini M., Parodi R., Passaggio S., Pastore F.C., Patrignani C., Pia M.G., Priano C., Robutti E., Santroni A., Bartoldus R., Dignan T., Hamilton R., Mallik U., Cochran J., Crawley H.B., Fischer P.A., Lamsa J., McKay R., Meyer W.T., Rosenberg E.I., Albert J.N., Beigbeder C., Benkebil M., Breton D., Cizeron R., Du S., Grosdidier G., Hast C., Hocker A., Lacker H.M., LePeltier V., Lutz A.M., Plaszczynski S., Schune M.H., Trincaz-Duvoid S., Truong K., Valassi A., Wormser G., Alford O., Behne D., Bionta R.M., Bowman J., Brigljevic V., Brooks A., Dacosta V.A., Fackler O., Fujino D., Harper M., Lange D.J., Mugge M., O'Connor T.G., Olson H., Ott L., Parker E., Pedrotti B., Roeben M., Shi X., van Bibber K., Wenaus T.J., Wright D.M., Wuest C.R., Yamamoto B., Carroll M., Cooke P., Fry J.R., Gabathuler E., Gamet R., George M., Kay M., McMahon S., Muir A., Payne D.J., Sloane R.J., Sutcliffe P., Touramanis C., Aspinwall M.L., Bowerman D.A., Dauncey P.D., Eschrich I., Gunawardane N.J.W., Martin R., Nash J.A., Price D.R., Sanders P., Smith D., Azzopardi D.E., Back J.J., Dixon P., Harrison P.F., Newman-Coburn D., Potter R.J.L., Shorthouse H.W., Williams M.I., Vidal P.B., Cowan G., George S., Green M.G., Kurup A., Marker C.E., McGrath P., McMahon T.R., Salvatore F., Scott I., Vaitsas G., Brown D., Davis C.L., Li Y., Pavlovich J., Allison J., Barlow R.J., Boyd J.T., Fullwood J., Jackson F., Khan A., Lafferty G.D., Savvas N., Simopoulos E.T., Thompson R.J., Weatherall J.H., Bard R., Dallapiccola C., Farbin A., Jawahery A., Lillard V., Olsen J., Roberts D.A., Schieck J.R., Blaylock G., Flood K.T., Hertzbach S.S., Kofler R., Lin C.S., Willocq S., Wittlin J., Brau B., Cowan R., Taylor F., Yamamoto R.K., Britton D.I., Fernholz R., Houde M., Milek M., Patel P.M., Trischuk J., Lanni F., Palombo F., Bauer J.M., Booke M., Cremaldi L., Kroeger R., Reep M., Reidy J., Sanders D.A., Summers D.J., Arguin J.F., Beaulieu M., Martin J.P., Nief J.Y., Seitz R., Taras P., Woch A., Zacek V., Nicholson H., Sutton C.S., Cartaro C., Cavallo N., De Nardo G., Fabozzi F., Gatto C., Lista L., Piccolo D., Sciacca C., Cason N.M., LoSecco J.M., Alsmiller J.R.G., Gabriel T.A., Handler T., Heck J., Iwasaki M., Sinev N.B., Caracciolo R., Colecchia F., Dal Corso F., Galeazzi F., Marzolla M., Michelon G., Morandin M., Posocco M., Rotondo M., Santi S., Simonetto F., Stroili R., Torassa E., Voci C., Bailly P., Benayoun M., Briand H., Chauveau J., David P., De la Vaissiere C., Del Buono L., Genat J.-F., Hamon O., Lerusle Ph., Le Diberder F., Lebbolo H., Lory J., Martin L., Martinez-Vidal F., Roos L., Slark J., Versille S., Zhang B., Manfredi P.F., Ratti L., Re V., Speziali V., Frank E.D., Gladney L., Guo Q.H., Panetta J.H., Angelini C., Batignani G., Bettarini S., Bondioli M., Bosi F., Carpinelli M., Forti F., Gaddi A., Gagliardi D., Giorgi M.A., Lusiani A., Mammini P., Morganti M., Morsani F., Neri N., Profeti A., Paoloni E., Raffaelli F., Rama M., Rizzo G., Sandrelli F., Simi G., Triggiani G., Haire M., Judd D., Paick K., Turnbull L., Wagoner D.E., Albert J., Bula C., Kelsey M.H., Lu C., McDonald K.T., Miftakov V., Sands B., Schaffner S.F., Smith A.J.S., Tumanov A., Varnes E.W., Bronzini F., Buccheri A., Bulfon C., Cavoto G., del Re D., Ferrarotto F., Ferroni F., Fratini K., Lamanna E., Leonardi E., Mazzoni M.A., Morganti S., Piredda G., Safai Tehrani F., Serra M., Voena C., Waldi R., Jacques P.F., Kalelkar M., Plano R.J., Adye T., Claxton B., Dowdell J., Egede U., Franek B., Galagedera S., Geddes N.I., Gopal G.P., Kay J., Lidbury J., Madani S., Metealfe S., Metcalfe S., Markey G., Olley P., Watt M., Xella S.M., Aleksan R., Besson P., Bourgeois P., Convert P., De Domenico G., de Lesquen A., Emery S., Gaidot A., Ganzhur S.F., Georgette Z., Gosset L., Graffin P., Hamel de Monchenauk G., Herve S., Karolak M., Kozanecki W., Langer M., London G.W., Marques V., Mayer B., Micout P., Mols J.P., Mouly J.P., Penicho Y., Rolquin J., Serfass B., Toussaint J.C., Usseglio M., Vasseur G., Yeche C., Zito M., Copty N., Purohit M.V., Yumiceva F.X., Adam I., Adesanya A., Anlhony P.L., Aston D., Bartek J., Becla J., Bell R., Bloom E., Boeheim C.T., Boyarski A.M., Boyce R.F., Briggs D., Bulos F., Burgess W., Byers B., Calderini G., Chestau R., Claus R., Convery M.R., Coombes R., Cottrell L., Coupal D.P., Coward D.H., Craddock W.W., DeBarger S., DeStaebler H., Dorfan J., Doser M., Dunwoodie W., Dusatko J.E., Ecklund S., Fieguth T.H., Freytag D.R., Glanzman T., Godfrey G.L., Haller G., Hanushevsky A., Harris J., Hasan A., Hee C., Himel T., Huffer M.E., Hung T., Innes W.R., Jessop C.P., Kawahara H., Keller L., King M.E., Klaisner L., Krebs H.J., Langenegger U., Langeveld W., Leith D.W.G.S., Louie S.K., Luitz S., Luth V., Lynch H.L., McDonald J., Manzin G., Marsiske H., Mattison T., McCulloch M., McDougald M., McShurley D., Menke S., Messner R., Morii M., Mount R., Muller D.R., Nelson D., Nordby M., O'Grady C.P., Olavson L., O'Neill F.G., Oxoby G., Paolucci P., Pavel T., Perl J., Pertsova M., Petrak S., Putallaz G., Raines P.E., Ratcliff B.N., Reif R., Robertson S.H., Rochester L.S., Roodman A., Russel J.J., Sapozhnikov L., Saxton O.H., Schietinger T., Schindler R.H., Schwiening J., Sciolla G., Seeman J.T., Serbo V.V., Shapiro S., Skarpass K., Snyder A., Soderstrom E., Soha A., Spanier S.M., Stahl A., Stiles P., Su D., Sullivan M.K., Talby M., Tanaka H.A., Va'vra J., Wagner S.R., Wang R., Weber T., Weinstein A.J.R., White J.L., Wienands U., Wisniewski W.J., Young C.C., Yu N., Burchat P.R., Cheng C.H., Kirkby D., Meyer T.I., Roat C., Henderson R., Khan N., Berridge S., Bugg W., Cohn H., Hart E., Weidemann A.W., Benninger T., Izen J.M., Kitayama I., Lou X.C., Turcotte M., Bianchi F., Bona M., Daudo F., Di Girolamo B., Gamba D., Grosso P., Smol A., Trapani P.P., Zanin D., Bosisio L., Della Ricca G., Lanceri L., Pompili A., Poropat P., Prest M., Rashevskaia I., Vallazza E., Vuagnin G., Panvini R.S., Brown C., De Silva A., Kowalewski R., Pitman D., Roney J.M., Band H.R., Charles E., Dasu S., Elmer P., Johnson J.R., Nielsen J., Orejudos W., Pan Y., Prepost R., Scott I.J., Walsh J., Wu S.L., Yu Z., Zobernig H., Moore T.B., Neal H., Aubert, B., Bazan, A., Boucham, A., Boutigny, D., De Bonis, I., Favier, J., Gaillard, J. M., Jeremie, A., Karyotakis, Y., Le Flour, T., Lees, J. P., Lieunard, S., Petitpas, P., Robbe, P., Tisserand, V., Zachariadou, K., Palano, A., Chen, G. P., Chen, J. C., N. D., Qi, Rong, G., Wang, P., Zhu, Y. S., Eigen, G., Reinertsen, P. L., Stugu, B., Abbott, B., Abrams, G. S., Amerman, L., Borgland, A. W., Breon, A. B., Brown, D. N., Button Shafer, J., Clark, A. R., Dardin, S., Day, C., Dow, S. F., Fan, Q., Gaponenko, I., Gill, M. S., Goozen, F. R., Gowdy, S. J., Gritsan, A., Groysman, Y., Hernikl, C., Jacobsen, R. G., Jared, R. C., Kadel, R. W., Kadyk, J., Karcher, A., Kerth, L. T., Kipnis, I., Kluth, S., Kral, J. F., Lafever, R., Leclerc, C., Levi, M. E., Lewis, S. A., Lionberger, C., Liu, T., Long, M., Luo, L., Lynch, G., Luft, P., Mandelli, E., Marino, M., Marks, K., Matuk, C., Meyer, A. B., Minor, R., Mokhtarani, A., Momayezi, M., Nyman, M., Oddone, P. J., Ohnemus, J., Oshatz, D., Patton, S., Pedrali Noy, M., Perazzo, A., Peters, C., Pope, W., Pripstein, M., Quarrie, D. R., Rasson, J. E., Roe, N. A., Romosan, A., Ronan, M. T., Shelkov, V. G., Stone, R., Strother, P. D., Telnov, A. V., von der Lippe, H., Weber, T. F., Wenzel, W. A., Zizka, G., Bright Thomas, P. G., Hawkes, C. M., Kirk, A., Knowles, D. J., O'Neale, S. W., Watson, A. T., Watson, N. K., Deppermann, T., Koch, H., Krug, J., Kunze, M., Lewandowski, B., Peters, K., Schmuecker, H., Steinke, M., Andress, J. C., Barlow, N. R., Bhimji, W., Chevalier, N., Clark, P. J., Cottingham, W. N., De Groot, N., Dyce, N., Foster, B., Mass, A., Mcfall, J. D., Wallom, D., Wilson, F. F., Abe, K., Hearty, C., Mckenna, J. A., Thiessen, D., Camanzi, B., Harrison, T. J., Mckemey, A. K., Tinslay, J., Antohin, E. I., Blinov, V. E., Bukin, A. D., Bukin, D. A., Buzykaev, A. R., Dubrovin, M. S., Golubev, V. B., Ivanchenko, V. N., Kolachev, G. M., Korol, A. A., Kravchenko, E. A., Mikhailov, S. F., Onuchin, A. P., Salnikov, A. A., Serednyakov, S. I., Skovpen, Y. u. I., Telnov, V. I., Yushkov, A. N., Booth, J., Lankford, A. J., Mandelkern, M., Pier, S., Stoker, D. P., Zioulas, G., Ahsan, A., Arisaka, K., Buchanan, C., Chun, S., Faccini, R., Macfarlane, D. B., Prell, S. A., Rahatlou, S. h., Raven, G., Sharma, V., Burke, S., Callahan, D., Campagnari, C., Dahmes, B., Hale, D., Hart, P. A., Kuznetsova, N., Kyre, S., Levy, S. L., Long, O., Lu, A., May, J., Richman, J. D., Verkerke, W., Witherell, M., Yellin, S., Beringer, J., Dewitt, J., Dorfan, D. E., Eisner, A. M., Frey, A., Grillo, A. A., Grothe, M., Heusch, C. A., Johnson, R. P., Kroeger, W., Lockman, W. S., Pulliam, T., Rowe, W., Sadrozinski, H., Schalk, T., Schmitz, R. E., Schumm, B. A., Seiden, A., Spencer, E. N., Turri, M., Walkowiak, W., Wilder, M., Williams, D. C., Chen, E., Dubois Felsmann, G. P., Dvoretskii, A., Hanson, J. E., Hitlin, D. G., Kolomensky, Y. u. G., Metzler, S., Oyang, J., Porter, F. C., Ryd, A., Samuel, A., Weaver, M., Yang, S., Zhu, R. Y., Devmal, S., Geld, T. L., Jayatilleke, S., Jayatilleke, S. M., Mancinelli, G., Meadows, B. T., Sokoloff, M. D., Bloom, P., Broomer, B., Erdos, E., Fahey, S., Ford, W. T., Gaede, F., van Hoek, W. C., Johnson, D. R., Michael, A. K., Nauenberg, U., Olivas, A., Park, H., Rankin, P., Roy, J., Sen, S., Smith, J. G., Wagner, D. L., Blouw, J., Harton, J. L., Krishnamurthy, M., Soffer, A., Toki, W. H., Warner, D. W., Wilson, R. J., Zhang, J., Brandt, T., Brose, J., Dahlinger, G., Dickopp, M., Dubitzky, R. S., Eckstein, P., Futterschneider, H., Kocian, M. L., Krause, R., Müller Pfefferkorn, R., Schubert, K. R., Schwierz, R., Spaan, B., Wilden, L., Behr, L., Bernard, D., Bonneaud, G. R., Brochard, F., Cohen Tanugi, J., Ferrag, S., Fouque, G., Gastaldi, F., Matricon, P., Mora de Freitas, P., Renard, C., Roussot, E., T'Jampens, S., Thiebaux, C., Vasileiadis, G., Verderi, M., Anjomshoaa, A., Bernet, R., Di Lodovico, F., Muheim, F., Playfer, S., Swain, J. E., Falbo, M., Bozzi, C., Dittongo, S., Folegani, M., Piemontese, L., Ramusino, A. C., Treadwell, E., Anulli, F., Baldini Ferroli, R., Calcaterra, A., de Sangro, R., Falciai, D., Finocchiaro, G., Patteri, P., Peruzzi, I. M., Piccolo, M., Xie, Y., Zallo, A., Bagnasco, S., Buzzo, A., Contri, R., Crosetti, G., Fabbricatore, P., Farinon, S., Lo Vetere, M., Macri, M., Minutoli, S., Monge, M. R., Musenich, R., Pallavicini, M., Parodi, R., Passaggio, S., Pastore, F. C., Patrignani, C., Pia, M. G., Priano, C., Robutti, E., Santroni, A., Bartoldus, R., Dignan, T., Hamilton, R., Mallik, U., Cochran, J., Crawley, H. B., Fischer, P. A., Lamsa, J., Mckay, R., Meyer, W. T., Rosenberg, E. I., Albert, J. N., Beigbeder, C., Benkebil, M., Breton, D., Cizeron, R., Du, S., Grosdidier, G., Hast, C., Höcker, A., Lacker, H. M., Lepeltier, V., Lutz, A. M., Plaszczynski, S., Schune, M. H., Trincaz Duvoid, S., Truong, K., Valassi, A., Wormser, G., Alford, O., Behne, D., Bionta, R. M., Bowman, J., Brigljević, V., Brooks, A., Dacosta, V. A., Fackler, O., Fujino, D., Harper, M., Lange, D. J., Mugge, M., O'Connor, T. G., Olson, H., Ott, L., Parker, E., Pedrotti, B., Roeben, M., Shi, X., van Bibber, K., Wenaus, T. J., Wright, D. M., Wuest, C. R., Yamamoto, B., Carroll, M., Cooke, P., Fry, J. R., Gabathuler, E., Gamet, R., George, M., Kay, M., Mcmahon, S., Muir, A., Payne, D. J., Sloane, R. J., Sutcliffe, P., Touramanis, C., Aspinwall, M. L., Bowerman, D. A., Dauncey, P. D., Eschrich, I., Gunawardane, N. J. W., Martin, R., Nash, J. A., Price, D. R., Sanders, P., Smith, D., Azzopardi, D. E., Back, J. J., Dixon, P., Harrison, P. F., Newman Coburn, D., Potter, R. J. L., Shorthouse, H. W., Williams, M. I., Vidal, P. B., Cowan, G., George, S., Green, M. G., Kurup, A., Marker, C. E., Mcgrath, P., Mcmahon, T. R., Salvatore, F., Scott, I., Vaitsas, G., Brown, D., Davis, C. L., Li, Y., Pavlovich, J., Allison, J., Barlow, R. J., Boyd, J. T., Fullwood, J., Jackson, F., Khan, A., Lafferty, G. D., Savvas, N., Simopoulos, E. T., Thompson, R. J., Weatherall, J. H., Bard, R., Dallapiccola, C., Farbin, A., Jawahery, A., Lillard, V., Olsen, J., Roberts, D. A., Schieck, J. R., Blaylock, G., Flood, K. T., Hertzbach, S. S., Kofler, R., Lin, C. S., Willocq, S., Wittlin, J., Brau, B., Cowan, R., Taylor, F., Yamamoto, R. K., Britton, D. I., Fernholz, R., Houde, M., Milek, M., Patel, P. M., Trischuk, J., Lanni, F., Palombo, F., Bauer, J. M., Booke, M., Cremaldi, L., Kroeger, R., Reep, M., Reidy, J., Sanders, D. A., Summers, D. J., Arguin, J. F., Beaulieu, M., Martin, J. P., Nief, J. Y., Seitz, R., Taras, P., Woch, A., Zacek, V., Nicholson, H., Sutton, C. S., Cartaro, C., Cavallo, N., DE NARDO, Guglielmo, Fabozzi, F., Gatto, C., Lista, L., Piccolo, D., Sciacca, Crisostomo, Cason, N. M., Losecco, J. M., Alsmiller, J. R. G., Gabriel, T. A., Handler, T., Heck, J., Iwasaki, M., Sinev, N. B., Caracciolo, R., Colecchia, F., Dal Corso, F., Galeazzi, F., Marzolla, M., Michelon, G., Morandin, M., Posocco, M., Rotondo, M., Santi, S., Simonetto, F., Stroili, R., Torassa, E., Voci, C., Bailly, P., Benayoun, M., Briand, H., Chauveau, J., David, P., De la Vaissière, C., Del Buono, L., Genat, J. F., Hamon, O., Leruste, P. h., Le Diberder, F., Lebbolo, H., Lory, J., Martin, L., Martinez Vidal, F., Roos, L., Stark, J., Versillé, S., Zhang, B., Manfredi, P. F., Ratti, L., Re, V., Speziali, V., Frank, E. D., Gladney, L., Guo, Q. H., Panetta, J. H., Angelini, C., Batignani, G., Bettarini, S., Bondioli, M., Bosi, F., Carpinelli, M., Forti, F., Gaddi, A., Gagliardi, D., Giorgi, M. A., Lusiani, A., Mammini, P., Morganti, M., Morsani, F., Neri, N., Profeti, A., Paoloni, E., Raffaelli, F., Rama, M., Rizzo, G., Sandrelli, F., Simi, G., Triggiani, G., Haire, M., Judd, D., Paick, K., Turnbull, L., Wagoner, D. E., Albert, J., Bula, C., Kelsey, M. H., Lu, C., Mcdonald, K. T., Miftakov, V., Sands, B., Schaffner, S. F., Smith, A. J. S., Tumanov, A., Varnes, E. W., Bronzini, F., Buccheri, A., Bulfon, C., Cavoto, G., del Re, D., Ferrarotto, F., Ferroni, F., Fratini, K., Lamanna, E., Leonardi, E., Mazzoni, M. A., Morganti, S., Piredda, G., Safai Tehrani, F., Serra, M., Voena, C., Waldi, R., Jacques, P. F., Kalelkar, M., Plano, R. J., Adye, T., Claxton, B., Dowdell, J., Egede, U., Franek, B., Galagedera, S., Geddes, N. I., Gopal, G. P., Kay, J., Lidbury, J., Madani, S., Metcalfe, S., Markey, G., Olley, P., Watt, M., Xella, S. M., Aleksan, R., Besson, P., Bourgeois, P., Convert, P., De Domenico, G., de Lesquen, A., Emery, S., Gaidot, A., Ganzhur, S. F., Georgette, Z., Gosset, L., Graffin, P., Hamel de Monchenault, G., Hervé, S., Karolak, M., Kozanecki, W., Langer, M., London, G. W., Marques, V., Mayer, B., Micout, P., Mols, J. P., Mouly, J. P., Penichot, Y., Rolquin, J., Serfass, B., Toussaint, J. C., Usseglio, M., Vasseur, G., Yeche, C., Zito, M., Copty, N., Purohit, M. V., Yumiceva, F. X., Adam, I., Adesanya, A., Anthony, P. L., Aston, D., Bartelt, J., Becla, J., Bell, R., Bloom, E., Boeheim, C. T., Boyarski, A. M., Boyce, R. F., Briggs, D., Bulos, F., Burgess, W., Byers, B., Calderini, G., Chestnut, R., Claus, R., Convery, M. R., Coombes, R., Cottrell, L., Coupal, D. P., Coward, D. H., Craddock, W. W., Debarger, S., Destaebler, H., Dorfan, J., Doser, M., Dunwoodie, W., Dusatko, J. E., Ecklund, S., Fieguth, T. H., Freytag, D. R., Glanzman, T., Godfrey, G. L., Haller, G., Hanushevsky, A., Harris, J., Hasan, A., Hee, C., Himel, T., Huffer, M. E., Hung, T., Innes, W. R., Jessop, C. P., Kawahara, H., Keller, L., King, M. E., Klaisner, L., Krebs, H. J., Langenegger, U., Langeveld, W., Leith, D. W. G. S., Louie, S. K., Luitz, S., Luth, V., Lynch, H. L., Mcdonald, J., Manzin, G., Marsiske, H., Mattison, T., Mcculloch, M., Mcdougald, M., Mcshurley, D., Menke, S., Messner, R., Morii, M., Mount, R., Muller, D. R., Nelson, D., Nordby, M., O'Grady, C. P., Olavson, L., O'Neill, F. G., Oxoby, G., Paolucci, P., Pavel, T., Perl, J., Pertsova, M., Petrak, S., Putallaz, G., Raines, P. E., Ratcliff, B. N., Reif, R., Robertson, S. H., Rochester, L. S., Roodman, A., Russel, J. J., Sapozhnikov, L., Saxton, O. H., Schietinger, T., Schindler, R. H., Schwiening, J., Sciolla, G., Seeman, J. T., Serbo, V. V., Shapiro, S., Skarpass Sr, K., Snyder, A., Soderstrom, E., Soha, A., Spanier, S. M., Stahl, A., Stiles, P., Su, D., Sullivan, M. K., Talby, M., Tanaka, H. A., Va'Vra, J., Wagner, S. R., Wang, R., Weber, T., Weinstein, A. J. R., White, J. L., Wienands, U., Wisniewski, W. J., Young, C. C., Yu, N., Burchat, P. R., Cheng, C. H., Kirkby, D., Meyer, T. I., Roat, C., Henderson, R., Khan, N., Berridge, S., Bugg, W., Cohn, H., Hart, E., Weidemann, A. W., Benninger, T., Izen, J. M., Kitayama, I., Lou, X. C., Turcotte, M., Bianchi, F., Bona, M., Daudo, F., Di Girolamo, B., Gamba, D., Grosso, P., Smol, A., Trapani, P. P., Zanin, D., Bosisio, L., Della Ricca, G., Lanceri, L., Pompili, A., Poropat, P., Prest, M., Rashevskaia, I., Vallazza, E., Vuagnin, G., Panvini, R. S., Brown, C., De Silva, A., Kowalewski, R., Pitman, D., Roney, J. M., Band, H. R., Charles, E., Dasu, S., Elmer, P., Johnson, J. R., Nielsen, J., Orejudos, W., Pan, Y., Prepost, R., Scott, I. J., Walsh, J., S. L., Wu, Yu, Z., Zobernig, H., Moore, T. B., Neal, H., Aubert, B, Bazan, A, Boucham, A, Boutigny, D, De Bonis, I, Favier, J, Gaillard, Jm, Jeremie, A, Karyotakis, Y, Le Flour, T, Lees, Jp, Lieunard, S, Petitpas, P, Robbe, P, Tisserand, V, Zachariadou, K, Palano, A, Chen, Gp, Chen, Jc, Qi, Nd, Rong, G, Wang, P, Zhu, Y, Eigen, G, Reinertsen, Pl, Stugu, B, Abbott, B, Abrams, G, Amerman, L, Borgland, Aw, Breon, Ab, Brown, Dn, Button Shafer, J, Clark, Ar, Dardin, S, Day, C, Dow, Sf, Fan, Q, Gaponenko, I, Gill, M, Goozen, Fr, Gowdy, Sj, Gritsan, A, Groysman, Y, Hernikl, C, Jacobsen, Rg, Jared, Rc, Kadel, Rw, Kadyk, J, Karcher, A, Kerth, Lt, Kipnis, I, Kluth, S, Kral, Jf, Lafever, R, Leclerc, C, Levi, Me, Lewis, Sa, Lionberger, C, Liu, T, Long, M, Luo, L, Lynch, G, Luft, P, Mandelli, E, Marino, M, Marks, K, Matuk, C, Meyer, Ab, Minor, R, Mokhtarani, A, Momayezi, M, Nyman, M, Oddone, Pj, Ohnemus, J, Oshatz, D, Patton, S, Pedrali Noy, M, Perazzo, A, Peters, C, Pope, W, Pripstein, M, Quarrie, Dr, Rasson, Je, Roe, Na, Romosan, A, Ronan, Mt, Shelkov, Vg, Stone, R, Strother, Pd, Telnov, Av, von der Lippe, H, Weber, Tf, Wenzel, Wa, Zizka, G, Bright Thomas, Pg, Hawkes, Cm, Kirk, A, Knowles, Dj, O'Neale, Sw, Watson, At, Watson, Nk, Deppermann, T, Koch, H, Krug, J, Kunze, M, Lewandowski, B, Peters, K, Schmuecker, H, Steinke, M, Andress, Jc, Barlow, Nr, Bhimji, W, Chevalier, N, Clark, Pj, Cottingham, Wn, De Groot, N, Dyce, N, Foster, B, Mass, A, Mcfall, Jd, Wallom, D, Wilson, Ff, Abe, K, Hearty, C, Mckenna, Ja, Thiessen, D, Camanzi, B, Harrison, Tj, Mckemey, Ak, Tinslay, J, Antohin, Ei, Blinov, Ve, Bukin, Ad, Bukin, Da, Buzykaev, Ar, Dubrovin, M, Golubev, Vb, Ivanchenko, Vn, Kolachev, Gm, Korol, Aa, Kravchenko, Ea, Mikhailov, Sf, Onuchin, Ap, Salnikov, Aa, Serednyakov, Si, Skovpen, Yi, Telnov, Vi, Yushkov, An, Booth, J, Lankford, Aj, Mandelkern, M, Pier, S, Stoker, Dp, Zioulas, G, Ahsan, A, Arisaka, K, Buchanan, C, Chun, S, Faccini, R, Macfarlane, Db, Prell, Sa, Rahatlou, S, Raven, G, Sharma, V, Burke, S, Callahan, D, Campagnari, C, Dahmes, B, Hale, D, Hart, Pa, Kuznetsova, N, Kyre, S, Levy, Sl, Long, O, Lu, A, May, J, Richman, Jd, Verkerke, W, Witherell, M, Yellin, S, Beringer, J, Dewitt, J, Dorfan, De, Eisner, Am, Frey, A, Grillo, Aa, Grothe, M, Heusch, Ca, Johnson, Rp, Kroeger, W, Lockman, W, Pulliam, T, Rowe, W, Sadrozinski, H, Schalk, T, Schmitz, Re, Schumm, Ba, Seiden, A, Spencer, En, Turri, M, Walkowiak, W, Wilder, M, Williams, Dc, Chen, E, Dubois Felsmann, Gp, Dvoretskii, A, Hanson, Je, Hitlin, Dg, Kolomensky, Yg, Metzler, S, Oyang, J, Porter, Fc, Ryd, A, Samuel, A, Weaver, M, Yang, S, Zhu, Ry, Devmal, S, Geld, Tl, Jayatilleke, S, Jayatilleke, Sm, Mancinelli, G, Meadows, Bt, Sokoloff, Md, Bloom, P, Broomer, B, Erdos, E, Fahey, S, Ford, Wt, Gaede, F, van Hoek, Wc, Johnson, Dr, Michael, Ak, Nauenberg, U, Olivas, A, Park, H, Rankin, P, Roy, J, Sen, S, Smith, Jg, Wagner, Dl, Blouw, J, Harton, Jl, Krishnamurthy, M, Soffer, A, Toki, Wh, Warner, Dw, Wilson, Rj, Zhang, J, Brandt, T, Brose, J, Dahlinger, G, Dickopp, M, Dubitzky, R, Eckstein, P, Futterschneider, H, Kocian, Ml, Krause, R, Muller Pfefferkorn, R, Schubert, Kr, Schwierz, R, Spaan, B, Wilden, L, Behr, L, Bernard, D, Bonneaud, Gr, Brochard, F, Cohen Tanugi, J, Ferrag, S, Fouque, G, Gastaldi, F, Matricon, P, de Freitas, Pm, Renard, C, Roussot, E, T'Jampens, S, Thiebaux, C, Vasileiadis, G, Verderi, M, Anjomshoaa, A, Bernet, R, Di Lodovico, F, Muheim, F, Playfer, S, Swain, Je, Falbo, M, Bozzi, C, Dittongo, S, Folegani, M, Piemontese, L, Ramusino, Ac, Treadwell, E, Anulli, F, Baldini Ferroli, R, Calcaterra, A, de Sangro, R, Falciai, D, Finocchiaro, G, Patteri, P, Peruzzi, Im, Piccolo, M, Xie, Y, Zallo, A, Bagnasco, S, Buzzo, A, Contri, R, Crosetti, G, Fabbricatore, P, Farinon, S, Lo Vetere, M, Macri, M, Minutoli, S, Monge, Mr, Musenich, R, Pallavicini, M, Parodi, R, Passaggio, S, Pastore, Fc, Patrignani, C, Pia, Mg, Priano, C, Robutti, E, Santroni, A, Bartoldus, R, Dignan, T, Hamilton, R, Mallik, U, Cochran, J, Crawley, Hb, Fischer, Pa, Lamsa, J, Mckay, R, Meyer, Wt, Rosenberg, Ei, Albert, Jn, Beigbeder, C, Benkebil, M, Breton, D, Cizeron, R, Du, S, Grosdidier, G, Hast, C, Hocker, A, Lacker, Hm, Lepeltier, V, Lutz, Am, Plaszczynski, S, Schune, Mh, Trincaz Duvoid, S, Truong, K, Valassi, A, Wormser, G, Alford, O, Behne, D, Bionta, Rm, Bowman, J, Brigljevic, V, Brooks, A, Dacosta, Va, Fackler, O, Fujino, D, Harper, M, Lange, Dj, Mugge, M, O'Connor, Tg, Olson, H, Ott, L, Parker, E, Pedrotti, B, Roeben, M, Shi, X, van Bibber, K, Wenaus, Tj, Wright, Dm, Wuest, Cr, Yamamoto, B, Carroll, M, Cooke, P, Fry, Jr, Gabathuler, E, Gamet, R, George, M, Kay, M, Mcmahon, S, Muir, A, Payne, Dj, Sloane, Rj, Sutcliffe, P, Touramanis, C, Aspinwall, Ml, Bowerman, Da, Dauncey, Pd, Eschrich, I, Gunawardane, Njw, Martin, R, Nash, Ja, Price, Dr, Sanders, P, Smith, D, Azzopardi, De, Back, Jj, Dixon, P, Harrison, Pf, Newman Coburn, D, Potter, Rjl, Shorthouse, Hw, Williams, Mi, Vidal, Pb, Cowan, G, George, S, Green, Mg, Kurup, A, Marker, Ce, Mcgrath, P, Mcmahon, Tr, Salvatore, F, Scott, I, Vaitsas, G, Brown, D, Davis, Cl, Li, Y, Pavlovich, J, Allison, J, Barlow, Rj, Boyd, Jt, Fullwood, J, Jackson, F, Khan, A, Lafferty, Gd, Savvas, N, Simopoulos, Et, Thompson, Rj, Weatherall, Jh, Bard, R, Dallapiccola, C, Farbin, A, Jawahery, A, Lillard, V, Olsen, J, Roberts, Da, Schieck, Jr, Blaylock, G, Flood, Kt, Hertzbach, S, Kofler, R, Lin, C, Willocq, S, Wittlin, J, Brau, B, Cowan, R, Taylor, F, Yamamoto, Rk, Britton, Di, Fernholz, R, Houde, M, Milek, M, Patel, Pm, Trischuk, J, Lanni, F, Palombo, F, Bauer, Jm, Booke, M, Cremaldi, L, Kroeger, R, Reep, M, Reidy, J, Sanders, Da, Summers, Dj, Arguin, Jf, Beaulieu, M, Martin, Jp, Nief, Jy, Seitz, R, Taras, P, Woch, A, Zacek, V, Nicholson, H, Sutton, C, Cartaro, C, Cavallo, N, De Nardo, G, Fabozzi, F, Gatto, C, Lista, L, Piccolo, D, Sciacca, C, Cason, Nm, Losecco, Jm, Alsmiller, Jrg, Gabriel, Ta, Handler, T, Heck, J, Iwasaki, M, Sinev, Nb, Caracciolo, R, Colecchia, F, Dal Corso, F, Galeazzi, F, Marzolla, M, Michelon, G, Morandin, M, Posocco, M, Rotondo, M, Santi, S, Simonetto, F, Stroili, R, Torassa, E, Voci, C, Bailly, P, Benayoun, M, Briand, H, Chauveau, J, David, P, De la Vaissiere, C, Del Buono, L, Genat, Jf, Hamon, O, Leruste, P, Le Diberder, F, Lebbolo, H, Lory, J, Martin, L, Martinez Vidal, F, Roos, L, Stark, J, Versille, S, Zhang, B, Manfredi, Pf, Ratti, L, Re, V, Speziali, V, Frank, Ed, Gladney, L, Guo, Qh, Panetta, Jh, Angelini, C, Batignani, G, Bettarini, S, Bondioli, M, Bosi, F, Carpinelli, M, Forti, F, Gaddi, A, Gagliardi, D, Giorgi, Ma, Lusiani, Alberto, Mammini, P, Morganti, M, Morsani, F, Neri, N, Profeti, A, Paoloni, E, Raffaelli, F, Rama, M, Rizzo, G, Sandrelli, F, Simi, G, Triggiani, G, Haire, M, Judd, D, Paick, K, Turnbull, L, Wagoner, De, Albert, J, Bula, C, Kelsey, Mh, Lu, C, Mcdonald, Kt, Miftakov, V, Sands, B, Schaffner, Sf, Smith, Aj, Tumanov, A, Varnes, Ew, Bronzini, F, Buccheri, A, Bulfon, C, Cavoto, G, del Re, D, Ferrarotto, F, Ferroni, F, Fratini, K, Lamanna, E, Leonardi, E, Mazzoni, Ma, Morganti, S, Piredda, G, Tehrani, F, Serra, M, Voena, C, Waldi, R, Jacques, Pf, Kalelkar, M, Plano, Rj, Adye, T, Claxton, B, Dowdell, J, Egede, U, Franek, B, Galagedera, S, Geddes, Ni, Gopal, Gp, Kay, J, Lidbury, J, Madani, S, Metcalfe, S, Markey, G, Olley, P, Watt, M, Xella, Sm, Aleksan, R, Besson, P, Bourgeois, P, Convert, P, De Domenico, G, de Lesquen, A, Emery, S, Gaidot, A, Ganzhur, Sf, Georgette, Z, Gosset, L, Graffin, P, de Monchenault, Gh, Herve, S, Karolak, M, Kozanecki, W, Langer, M, London, Gw, Marques, V, Mayer, B, Micout, P, Mols, Jp, Mouly, Jp, Penichot, Y, Rolquin, J, Serfass, B, Toussaint, Jc, Usseglio, M, Vasseur, G, Yeche, C, Zito, M, Copty, N, Purohit, Mv, Yumiceva, Fx, Adam, I, Adesanya, A, Anthony, Pl, Aston, D, Bartelt, J, Becla, J, Bell, R, Bloom, E, Boeheim, Ct, Boyarski, Am, Boyce, Rf, Briggs, D, Bulos, F, Burgess, W, Byers, B, Calderini, G, Chestnut, R, Claus, R, Convery, Mr, Coombes, R, Cottrell, L, Coupal, Dp, Coward, Dh, Craddock, Ww, Debarger, S, Destaebler, H, Dorfan, J, Doser, M, Dunwoodie, W, Dusatko, Je, Ecklund, S, Fieguth, Th, Freytag, Dr, Glanzman, T, Godfrey, Gl, Haller, G, Hanushevsky, A, Harris, J, Hasan, A, Hee, C, Himel, T, Huffer, Me, Hung, T, Innes, Wr, Jessop, Cp, Kawahara, H, Keller, L, King, Me, Klaisner, L, Krebs, Hj, Langenegger, U, Langeveld, W, Leith, Dwg, Louie, Sk, Luitz, S, Luth, V, Lynch, Hl, Mcdonald, J, Manzin, G, Marsiske, H, Mattison, T, Mcculloch, M, Mcdougald, M, Mcshurley, D, Menke, S, Messner, R, Morii, M, Mount, R, Muller, Dr, Nelson, D, Nordby, M, O'Grady, Cp, Olavson, L, O'Neill, Fg, Oxoby, G, Paolucci, P, Pavel, T, Perl, J, Pertsova, M, Petrak, S, Putallaz, G, Raines, Pe, Ratcliff, Bn, Reif, R, Robertson, Sh, Rochester, L, Roodman, A, Russel, Jj, Sapozhnikov, L, Saxton, Oh, Schietinger, T, Schindler, Rh, Schwiening, J, Sciolla, G, Seeman, Jt, Serbo, Vv, Shapiro, S, Skarpass, K, Snyder, A, Soderstrom, E, Soha, A, Spanier, Sm, Stahl, A, Stiles, P, Su, D, Sullivan, Mk, Talby, M, Tanaka, Ha, Va'Vra, J, Wagner, Sr, Wang, R, Weber, T, Weinstein, Ajr, White, Jl, Wienands, U, Wisniewski, Wj, Young, Cc, Yu, N, Burchat, Pr, Cheng, Ch, Kirkby, D, Meyer, Ti, Roat, C, Henderson, R, Khan, N, Berridge, S, Bugg, W, Cohn, H, Hart, E, Weidemann, Aw, Benninger, T, Izen, Jm, Kitayama, I, Lou, Xc, Turcotte, M, Bianchi, F, Bona, M, Daudo, F, Di Girolamo, B, Gamba, D, Grosso, P, Smol, A, Trapani, Pp, Zanin, D, Bosisio, L, Della Ricca, G, Lanceri, L, Pompili, A, Poropat, P, Prest, M, Rashevskaia, I, Vallazza, E, Vuagnin, G, Panvini, R, Brown, C, De Silva, A, Kowalewski, R, Pitman, D, Roney, Jm, Band, Hr, Charles, E, Dasu, S, Elmer, P, Johnson, Jr, Nielsen, J, Orejudos, W, Pan, Y, Prepost, R, Scott, Ij, Walsh, J, Wu, Sl, Yu, Z, Zobernig, H, Moore, Tb, Gaillard, J, Lees, J, Chen, G, Chen, J, Qi, N, Reinertsen, P, Borgland, A, Breon, A, Clark, A, Dow, S, Goozen, F, Gowdy, S, Jacobsen, R, Jared, R, Kadel, R, Kerth, L, Kral, J, Levi, M, Lewis, S, Meyer, A, Oddone, P, Quarrie, D, Rasson, J, Roe, N, Ronan, M, Shelkov, V, Strother, P, Telnov, A, Wenzel, W, Bright Thomas, P, Hawkes, C, Knowles, D, O'Neale, S, Watson, A, Watson, N, Andress, J, Barlow, N, Clark, P, Cottingham, W, Mcfall, J, Wilson, F, Mckenna, J, Harrison, T, Mckemey, A, Antohin, E, Blinov, V, Bukin, A, Bukin, D, Buzykaev, A, Golubev, V, Ivanchenko, V, Kolachev, G, Korol, A, Kravchenko, E, Mikhailov, S, Onuchin, A, Salnikov, A, Serednyakov, S, Skovpen, Y, Telnov, V, Yushkov, A, Lankford, A, Stoker, D, Macfarlane, D, Prell, S, Hart, P, Levy, S, Richman, J, Dorfan, D, Eisner, A, Grillo, A, Heusch, C, Johnson, R, Schmitz, R, Schumm, B, Spencer, E, Williams, D, Dubois Felsmann, G, Hanson, J, Hitlin, D, Kolomensky, Y, Porter, F, Zhu, R, Geld, T, Meadows, B, Sokoloff, M, Ford, W, van Hoek, W, Johnson, D, Michael, A, Smith, J, Wagner, D, Harton, J, Toki, W, Warner, D, Wilson, R, Kocian, M, Schubert, K, Bonneaud, G, de Freitas, P, Swain, J, Ramusino, A, Peruzzi, I, Monge, M, Pastore, F, Pia, M, Crawley, H, Fischer, P, Meyer, W, Rosenberg, E, Lacker, H, Lutz, A, Schune, M, Bionta, R, Dacosta, V, Lange, D, O'Connor, T, Wenaus, T, Wright, D, Wuest, C, Fry, J, Payne, D, Sloane, R, Aspinwall, M, Bowerman, D, Dauncey, P, Gunawardane, N, Nash, J, Price, D, Azzopardi, D, Back, J, Harrison, P, Potter, R, Shorthouse, H, Williams, M, Vidal, P, Green, M, Marker, C, Mcmahon, T, Davis, C, Barlow, R, Boyd, J, Lafferty, G, Simopoulos, E, Thompson, R, Weatherall, J, Roberts, D, Schieck, J, Flood, K, Yamamoto, R, Britton, D, Patel, P, Bauer, J, Sanders, D, Summers, D, Arguin, J, Martin, J, Nief, J, Cason, N, Losecco, J, Alsmiller, J, Gabriel, T, Sinev, N, Genat, J, Manfredi, P, Frank, E, Guo, Q, Panetta, J, Giorgi, M, Lusiani, A, Wagoner, D, Kelsey, M, Mcdonald, K, Schaffner, S, Smith, A, Varnes, E, Mazzoni, M, Jacques, P, Plano, R, Geddes, N, Gopal, G, Xella, S, Ganzhur, S, de Monchenault, G, London, G, Mols, J, Mouly, J, Toussaint, J, Purohit, M, Yumiceva, F, Anthony, P, Boeheim, C, Boyarski, A, Boyce, R, Convery, M, Coupal, D, Coward, D, Craddock, W, Dusatko, J, Fieguth, T, Freytag, D, Godfrey, G, Huffer, M, Innes, W, Jessop, C, King, M, Krebs, H, Leith, D, Louie, S, Lynch, H, Muller, D, O'Grady, C, O'Neill, F, Raines, P, Ratcliff, B, Robertson, S, Russel, J, Saxton, O, Schindler, R, Seeman, J, Serbo, V, Spanier, S, Sullivan, M, Tanaka, H, Wagner, S, Weinstein, A, White, J, Wisniewski, W, Young, C, Burchat, P, Cheng, C, Meyer, T, Weidemann, A, Izen, J, Lou, X, Trapani, P, Roney, J, Band, H, Johnson, J, Wu, S, Moore, T, and Neal, H
- Subjects
Nuclear and High Energy Physics ,BABAR ,B factory ,CP violation ,detector ,data acquisition ,trigger ,Physics::Instrumentation and Detectors ,Cherenkov detector ,FOS: Physical sciences ,BaBar experiment ,B meson ,Tracking (particle physics) ,PARTICLE PHYSICS ,PEP2 ,01 natural sciences ,Particle detector ,Particle identification ,High Energy Physics - Experiment ,law.invention ,Nuclear physics ,High Energy Physics - Experiment (hep-ex) ,Particle Physic ,law ,0103 physical sciences ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,010306 general physics ,Instrumentation ,Physics ,010308 nuclear & particles physics ,Detector ,Particle accelerator ,BABAR detector ,Semiconductor detector ,High Energy Physics::Experiment - Abstract
BABAR, the detector for the SLAC PEP-II asymmetric e+e- B Factory operating at the upsilon 4S resonance, was designed to allow comprehensive studies of CP-violation in B-meson decays. Charged particle tracks are measured in a multi-layer silicon vertex tracker surrounded by a cylindrical wire drift chamber. Electromagentic showers from electrons and photons are detected in an array of CsI crystals located just inside the solenoidal coil of a superconducting magnet. Muons and neutral hadrons are identified by arrays of resistive plate chambers inserted into gaps in the steel flux return of the magnet. Charged hadrons are identified by dE/dx measurements in the tracking detectors and in a ring-imaging Cherenkov detector surrounding the drift chamber. The trigger, data acquisition and data-monitoring systems, VME- and network-based, are controlled by custom-designed online software. Details of the layout and performance of the detector components and their associated electronics and software are presented., 118 pages, 94 figure files, to be published in Nucl. Inst. and Methods
- Published
- 2002
- Full Text
- View/download PDF
46. Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses
- Author
-
Costello, J.L., Kershaw, C.J., Castelli, L.M., Talavera, D., Rowe, W., Sims, P.F.G., Ashe, M.P., Grant, C.M., Hubbard, S.J., and Pavitt, G.D.
- Abstract
BACKGROUND: Translation factors eIF4E and eIF4G form eIF4F, which interacts with the messenger RNA (mRNA) 5' cap to promote ribosome recruitment and translation initiation. Variations in the association of eIF4F with individual mRNAs likely contribute to differences in translation initiation frequencies between mRNAs. As translation initiation is globally reprogrammed by environmental stresses, we were interested in determining whether eIF4F interactions with individual mRNAs are reprogrammed and how this may contribute to global environmental stress responses. RESULTS: Using a tagged-factor protein capture and RNA-sequencing (RNA-seq) approach, we have assessed how mRNA associations with eIF4E, eIF4G1 and eIF4G2 change globally in response to three defined stresses that each cause a rapid attenuation of protein synthesis: oxidative stress induced by hydrogen peroxide and nutrient stresses caused by amino acid or glucose withdrawal. We find that acute stress leads to dynamic and unexpected changes in eIF4F-mRNA interactions that are shared among each factor and across the stresses imposed. eIF4F-mRNA interactions stabilised by stress are predominantly associated with translational repression, while more actively initiating mRNAs become relatively depleted for eIF4F. Simultaneously, other mRNAs are insulated from these stress-induced changes in eIF4F association. CONCLUSION: Dynamic eIF4F-mRNA interaction changes are part of a coordinated early translational control response shared across environmental stresses. Our data are compatible with a model where multiple mRNA closed-loop complexes form with differing stability. Hence, unexpectedly, in the absence of other stabilising factors, rapid translation initiation on mRNAs correlates with less stable eIF4F interactions.
- Published
- 2017
47. Developmental Progress in Conducting Action Research
- Author
-
Sankaran, S, Rowe, W, and Cady, P
- Subjects
Business & Management - Abstract
Copyright © 2017 John Wiley & Sons, Ltd. Action research is widely acknowledged as an effective framework of empowerment and emancipation to improve a social situation or condition—an intent that appeals to leaders wishing to create improvement, particularly in low socioeconomic and disadvantaged communities. Validity of such espousals has been substantially unexplored, and where evaluations have occurred, they have been focused more on process than impact. A group of international researchers were engaged in an evaluative study of more than 100 action research initiatives, using a variety of methods, tools and conceptual frameworks. The maturity model for action research is one of the conceptual frameworks adopted in this Evaluative Study of Action Research. Maturity models have their origins in the capability maturity model developed to address the poor performance of software projects delivered to the US Department of Defence in the 1980s. The purpose of the capability maturity model was to help contractors increase capability to improve their software engineering processes from an ad hoc state to a more formal and repeatable state and, eventually, to optimize the processes to deliver consistent outcomes. Maturity models have now found their way into many other organizational contexts, such as project management, knowledge management, process management and research capability. However, the term ‘maturity model’ is usually associated with business jargon and quantitative research. Therefore, the authors of this article felt the concept could be made more palatable to action researchers by rephrasing it as ‘maturity profile’ to improve the ways in which they manage their projects to deliver sustainable outcomes. This resulted in the development of the maturity profile described in this article. Copyright © 2017 John Wiley & Sons, Ltd.
- Published
- 2017
48. Dominant leaders
- Author
-
Tang, Jianyun, primary, Crossan, Mary, additional, and Rowe, W. Glenn, additional
- Published
- 2019
- Full Text
- View/download PDF
49. Towards High Productivity in Precision Grinding
- Author
-
Rowe, W., primary
- Published
- 2018
- Full Text
- View/download PDF
50. Temperature regulates NF-κB dynamics and function through timing of A20 transcription
- Author
-
Harper, C V, Woodcock, D J, Lam, C, Garcia-Albornoz, M, Adamson, A, Ashall, L, Rowe, W, Downton, P, Schmidt, L, West, S, Spiller, D G, Rand, D A, White, M R H, Harper, C V, Woodcock, D J, Lam, C, Garcia-Albornoz, M, Adamson, A, Ashall, L, Rowe, W, Downton, P, Schmidt, L, West, S, Spiller, D G, Rand, D A, and White, M R H
- Abstract
NF-κB signaling plays a pivotal role in control of the inflammatory response. We investigated how the dynamics and function of NF-κB were affected by temperature within the mammalian physiological range (34 °C to 40 °C). An increase in temperature led to an increase in NF-κB nuclear/cytoplasmic oscillation frequency following Tumor Necrosis Factor alpha (TNFα) stimulation. Mathematical modeling suggested that this temperature sensitivity might be due to an A20-dependent mechanism, and A20 silencing removed the sensitivity to increased temperature. The timing of the early response of a key set of NF-κB target genes showed strong temperature dependence. The cytokine-induced expression of many (but not all) later genes was insensitive to temperature change (suggesting that they might be functionally temperature-compensated). Moreover, a set of temperature- and TNFα-regulated genes were implicated in NF-κB cross-talk with key cell-fate-controlling pathways. In conclusion, NF-κB dynamics and target gene expression are modulated by temperature and can accurately transmit multidimensional information to control inflammation.
- Published
- 2018
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.