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2. Standardization of molecular monitoring of CML : results and recommendations from the European treatment and outcome study

Author

White, Helen E., Salmon, Matthew, Albano, Francesco, Andersen, Christina Sos Auour, Balabanov, Stefan, Balatzenko, Gueorgui, Barbany, Gisela, Cayuela, Jean-Michel, Cerveira, Nuno, Cochaux, Pascale, Colomer, Dolors, Coriu, Daniel, Diamond, Joana, Dietz, Christian, Dulucq, Stephanie, Engvall, Marie, Franke, Georg N., Gineikiene-Valentine, Egle, Gniot, Michal, Gomez-Casares, Maria Teresa, Gottardi, Enrico, Hayden, Chloe, Hayette, Sandrine, Hedblom, Andreas, Ilea, Anca, Izzo, Barbara, Jimenez-Velasco, Antonio, Jurcek, Tomas, Kairisto, Veli, Langabeer, Stephen E., Lion, Thomas, Meggyesi, Nora, Mesanovic, Semir, Mihok, Luboslav, Mitterbauer-Hohendanner, Gerlinde, Moeckel, Sylvia, Naumann, Nicole, Nibourel, Olivier, Oppliger Leibundgut, Elisabeth, Panayiotidis, Panayiotis, Podgornik, Helena, Pott, Christiane, Rapado, Inmaculada, Rose, Susan J., Schaefer, Vivien, Touloumenidou, Tasoula, Veigaard, Christopher, Venniker-Punt, Bianca, Venturi, Claudia, Vigneri, Paolo, Vorkinn, Ingvild, Wilkinson, Elizabeth, Zadro, Renata, Zawada, Magdalena, Zizkova, Hana, Mueller, Martin C., Saussele, Susanne, Ernst, Thomas, Machova Polakova, Katerina, Hochhaus, Andreas, Cross, Nicholas C. P., White, Helen E., Salmon, Matthew, Albano, Francesco, Andersen, Christina Sos Auour, Balabanov, Stefan, Balatzenko, Gueorgui, Barbany, Gisela, Cayuela, Jean-Michel, Cerveira, Nuno, Cochaux, Pascale, Colomer, Dolors, Coriu, Daniel, Diamond, Joana, Dietz, Christian, Dulucq, Stephanie, Engvall, Marie, Franke, Georg N., Gineikiene-Valentine, Egle, Gniot, Michal, Gomez-Casares, Maria Teresa, Gottardi, Enrico, Hayden, Chloe, Hayette, Sandrine, Hedblom, Andreas, Ilea, Anca, Izzo, Barbara, Jimenez-Velasco, Antonio, Jurcek, Tomas, Kairisto, Veli, Langabeer, Stephen E., Lion, Thomas, Meggyesi, Nora, Mesanovic, Semir, Mihok, Luboslav, Mitterbauer-Hohendanner, Gerlinde, Moeckel, Sylvia, Naumann, Nicole, Nibourel, Olivier, Oppliger Leibundgut, Elisabeth, Panayiotidis, Panayiotis, Podgornik, Helena, Pott, Christiane, Rapado, Inmaculada, Rose, Susan J., Schaefer, Vivien, Touloumenidou, Tasoula, Veigaard, Christopher, Venniker-Punt, Bianca, Venturi, Claudia, Vigneri, Paolo, Vorkinn, Ingvild, Wilkinson, Elizabeth, Zadro, Renata, Zawada, Magdalena, Zizkova, Hana, Mueller, Martin C., Saussele, Susanne, Ernst, Thomas, Machova Polakova, Katerina, Hochhaus, Andreas, and Cross, Nicholas C. P.

Abstract

Standardized monitoring of BCR::ABL1 mRNA levels is essential for the management of chronic myeloid leukemia (CML) patients. From 2016 to 2021 the European Treatment and Outcome Study for CML (EUTOS) explored the use of secondary, lyophilized cell-based BCR::ABL1 reference panels traceable to the World Health Organization primary reference material to standardize and validate local laboratory tests. Panels were used to assign and validate conversion factors (CFs) to the International Scale and assess the ability of laboratories to assess deep molecular response (DMR). The study also explored aspects of internal quality control. The percentage of EUTOS reference laboratories (n = 50) with CFs validated as optimal or satisfactory increased from 67.5% to 97.6% and 36.4% to 91.7% for ABL1 and GUSB, respectively, during the study period and 98% of laboratories were able to detect MR4.5 in most samples. Laboratories with unvalidated CFs had a higher coefficient of variation for BCR::ABL1(IS) and some laboratories had a limit of blank greater than zero which could affect the accurate reporting of DMR. Our study indicates that secondary reference panels can be used effectively to obtain and validate CFs in a manner equivalent to sample exchange and can also be used to monitor additional aspects of quality assurance.

Published
2022
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3. Defining child neglect: evolution, influences, and issues

Author

Rose, Susan J. and Meezan, William

Subjects
Child abuse -- Research, Child welfare -- Services, Social sciences
Abstract

In this article, we trace the evolution of the concept of child neglect in state statutes and the professional literature. We discuss two competing perspectives in defining child neglect: parental behavior and potential or actual harm to the child. We also analyze the literature on cultural group variation in defining neglect, as well as variations in the definition of neglect based on social role. Conclusions for child welfare practice and policy are presented.

Published
1993

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