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1. Seed morphometrics unravels the evolutionary history of grapevine in France

Author

Bouby, L., Bonhomme, V., Ivorra, S., Bacilieri, R., Ben Makhad, S., Bonnaire, E., Cabanis, M., Derreumaux, M., Dietsch-Sellami, M. F., Durand, F., Evin, A., Figueiral, I., Flottes, L., Hallavant, C., Jedrusiak, F., Lacombe, T., Marinval, P., Martin, L., Matterne, V., Pagnoux, C., Pastor, T., Pinaud, R., Pradat, B., Preiss, S., Ros, J., Rovira, N., Ruas, M. P., Schaal, C., Tillier, M., Toulemonde, F., Wiethold, J., and Terral, J. F.

Published
2024
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2. Results of the EURADOS international comparison exercise on neutron spectra unfolding in Bonner spheres spectrometry

Author

Gómez-Ros, J. M., Bedogni, R., Domingo, C., Eakins, J. S., Roberts, N., and Tanner, R. J.

Subjects
Physics - Medical Physics
Abstract

This paper summarizes the results obtained from an international comparison exercise on neutron spectra unfolding in Bonner spheres spectrometry, organized within the activities of EURADOS working group 6: computational dosimetry. Four realistic situations were considered: a medical accelerator, a workplace field, an irradiation room and a skyshine scenario. The reference solutions are presented, given in terms of idealized fluence-energy distributions and dose rates, along with details of their derivation using verified Monte Carlo codes. The wide variety of unfolded results that were submitted by the participants are then provided, with some shown to agree well with the reference solutions but others showing significant energy-dependent discrepancies. Finally, explanations for some of these discrepancies are proposed, along with suggested methods for how they might be improved., Comment: 15 pages, 7 Figures, 7 Tables

Published
2022
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3. Safety and efficacy of encorafenib–cetuximab combination in BRAFV600E-mutated metastatic colorectal cancer: real-world evidence from the CONFIDENCE Spanish multicenter study

Author

Fernández-Montes, A., Ros, J., García-Alfonso, P., Graña, B., Brozos-Vázquez, E., Melián, M., Jiménez-Gordo, A.M<ce:sup loc='post">ª</ce:sup>, Martínez de Castro, E., Busquier, I., Ferrández Arias, A., Grávalos, C., Covela, M., Ruíz-Casado, A., González-Flores, E., Safont, M<ce:sup loc='post">ª</ce:sup> J., Cano, J.M<ce:sup loc='post">ª</ce:sup>, Alonso-López, C., Gómez-Reina, M<ce:sup loc='post">ª</ce:sup> J., Donnay, O., Manzano-Mozo, J.L., Sampedro Domarco, P., Falcó, E., Rodríguez, N., García-Benito, C., and Aranda, E.

Published
2024
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4. Efficacy and safety of the combination of encorafenib/cetuximab with or without binimetinib in patients with BRAF V600E-mutated metastatic colorectal cancer: an AGEO real-world multicenter study

Author

Gallois, C., Bergen, E.S., Auclin, É., Pernot, S., Higué, J., Trouilloud, I., Touchefeu, Y., Turpin, A., Mazard, T., Sartore-Bianchi, A., Prenen, H., Alberti, A., Pilla, L., Cuissy, S., Wookey, V., Perret, A., Melchior, C., Artru, P., Dubreuil, O., Drouillard, A., Doat, S., Lavolé, J., Basile, D., Perkins, G., Jary, M., Stintzing, S., Ros, J., Tougeron, D., and Taieb, J.

Published
2024
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5. Development of gamma insensitive silicon carbide diagnostics to qualify intense thermal and epithermal neutron fields

Author

Planell, O. Sans, Costa, M., Durisi, E., Lega, A., Mafucci, E., Menzio, L., Monti, V., Visca, L., Bedogni, R., Treccani, M., Pola, A., Bortot, D., Alikaniotis, K., Giannini, G., and Gomez-Ros, J. M.

Subjects
Physics - Instrumentation and Detectors
Abstract

The e_LiBANS project aims at creating accelerator based compact neutron facilities for diverse interdisciplinary applications. After the successful setting up and characterization of a thermal neutron source based on a medical electron LINAC, a similar assembly for epithermal neutrons has been developed. The project is based on an Elekta 18 MV LINAC coupled with a photoconverter-moderator system which deploys the ({\gamma},n) photonuclear reaction to convert a bremsstrahlung photon beam into a neutron field. This communication describes the development of novel diagnostics to qualify the thermal and epithermal neutron fields that have been produced. In particular, a proof of concept for the use of silicon carbide photodiodes as a thermal neutron rate detector is presented., Comment: 10 pages, 10 figures, accepted for publication to JINST on the 17th April 2020

Published
2020
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6. Estimation of lateral track irregularity through Kalman filtering techniques

Author

Munoz, S., Ros, J., and Escalona, J. L.

Subjects
Computer Science - Computational Engineering, Finance, and Science, Electrical Engineering and Systems Science - Signal Processing, G.1, G.3, J.6
Abstract

The aim of this work is to develop a model-based methodology for monitoring lateral track irregularities based on the use of inertial sensors mounted on an in-service train. To this end, a gyroscope is used to measure the wheelset yaw angular velocity and two accelerometers are used to measure lateral acceleration of the wheelset and the bogie frame. Using a highly simplified linear bogie model that is able to capture the most relevant dynamic behaviour allows for the set-up of a very efficient Kalman-based monitoring strategy. The behaviour of the designed filter is assessed through the use of a detailed multibody model of an in-service vehicle running on a straight track with realistic irregularities. The model output is used to generate virtual measurements that are subsequently used to run the filter and validate the proposed estimator. In addition, the equivalent parameters of the simplified model are identified based on these simulations. In order to prove the robustness of the proposed technique, a systematic parametric analysis has been performed. The results obtained with the proposed method are promising, showing high accuracy and robustness for monitoring lateral alignment on straight tracks, with a very low computational cost., Comment: 17 pages and 8 figures

Published
2020

7. Establishment of patient-derived tumor organoids to functionally inform treatment decisions in metastatic colorectal cancer

Author

Martini, G., Belli, V., Napolitano, S., Ciaramella, V., Ciardiello, D., Belli, A., Izzo, F., Avallone, A., Selvaggi, F., Menegon Tasselli, F., Santaniello, W., Franco, R., Puig, I., Ramirez, L., Chicote, I., Mancuso, F., Caratu, G., Serres, X., Fasani, R., Jimenez, J., Ros, J., Baraibar, I., Mulet, N., Della Corte, C.M., Troiani, T., Vivancos, A., Dienstmann, R., Elez, E., Palmer, H.G., Tabernero, J., Martinelli, E., Ciardiello, F., and Argilés, G.

Published
2023
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10. Results of the first user program on the Homogenous Thermal Neutron Source HOTNES (ENEA / INFN)

Author

Sperduti, A., Angelone, M., Bedogni, R., Claps, G., Diociaiuti, E., Domingo, C., Donghia, R., Giovannella, S., Gomez-Ros, J. M., Irazola-Rosales, L., Loreti, S., Monti, V., Miscetti, S., Murtas, F., Pagano, G., Pillon, M., Pilotti, R., Pola, A., Romero-Expósito, M., Sánchez-Doblado, F., Sans-Planell, O., Scherillo, A., Soldani, E., Treccani, M., and Pietropaolo, A.

Subjects
Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

The HOmogeneous Thermal NEutron Source (HOTNES) is a new type of thermal neutron irradiation assembly developed by the ENEA-INFN collaboration. The facility is fully characterized in terms of neutron field and dosimetric quantities, by either computational and experimental methods. This paper reports the results of the first "HOTNES users program", carried out in 2016, and covering a variety of thermal neutron active detectors such as scintillators, solid-state, single crystal diamond and gaseous detectors.

Published
2018
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11. Gamma-ray imaging system for real-time measurements in nuclear waste characterisation

Author

Caballero, L., Colomer, F. Albiol, Bellot, A. Corbi, Rodriguez, P. Olleros, Ros, J. Agramunt, Domingo-Pardo, C., Nieto, J. L. Leganes, Contreras, P., and Magan, D. L. Perez

Subjects
Physics - Instrumentation and Detectors
Abstract

A compact, portable and large field-of-view gamma camera to identify, locate and quantify gamma-ray emitting radioisotopes in real-time has been developed. The device delivers spectroscopic and imaging capabilities, which allow one to use it in a variety of nuclear waste characterisation scenarios, such as radioactivity monitoring in nuclear power plants and more specifically for the decommissioning of nuclear facilities. The technical development of this apparatus and some examples of its application in field measurements are reported in this article. The performance of the presented gamma-camera is also benchmarked against other conventional techniques.

Published
2018
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13. Exceptional outburst of the blazar CTA 102 in 2012: The GASP-WEBT campaign and its extension

Author

Larionov, V. M., Villata, M., Raiteri, C. M., Jorstad, S. G., Marscher, A. P., Agudo, I., Smith, P. S., Acosta-Pulido, J. A., Arévalo, M. J., Arkharov, A. A., Bachev, R., Blinov, D. A., Borisov, G., Borman, G. A., Bozhilov, V., Bueno, A., Carnerero, M. I., Carosati, D., Casadio, C., Chen, W. P., Clemens, D. P., Di Paola, A., Ehgamberdiev, Sh. A., Gómez, J. L., González-Morales, P. A, Griñón-Marín, A., Grishina, T. S., Hagen-Thorn, V. A., Ibryamov, S., Itoh, R., Kopatskaya, E. N., Koptelova, E., Lázaro, C., Larionova, E. G., Larionova, L. V., Manilla-Robles, A., Metodieva, Y., Milanova, Yu. V., Mirzaqulov, D. O., Molina, S. N., Morozova, D. A., Nazarov, S. V., Ovcharov, E., Peneva, S., Ros, J. A., Sadun, A. C., Savchenko, S. S., Semkov, E., Sergeev, S. G., Strigachev, A., Troitskaya, Yu. V., and Troitsky, I. S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

After several years of quiescence, the blazar CTA 102 underwent an exceptional outburst in 2012 September-October. The flare was tracked from gamma-ray to near-infrared frequencies, including Fermi and Swift data as well as photometric and polarimetric data from several observatories. An intensive GASP-WEBT collaboration campaign in optical and NIR bands, with an addition of previously unpublished archival data and extension through fall 2015, allows comparison of this outburst with the previous activity period of this blazar in 2004-2005. We find remarkable similarity between the optical and gamma-ray behaviour of CTA 102 during the outburst, with a time lag between the two light curves of ~1 hour, indicative of co-spatiality of the optical and gamma-ray emission regions. The relation between the gamma-ray and optical fluxes is consistent with the SSC mechanism, with a quadratic dependence of the SSC gamma-ray flux on the synchrotron optical flux evident in the post-outburst stage. However, the gamma-ray/optical relationship is linear during the outburst; we attribute this to changes in the Doppler factor. A strong harder-when-brighter spectral dependence is seen both the in gamma-ray and optical non-thermal emission. This hardening can be explained by convexity of the UV-NIR spectrum that moves to higher frequencies owing to an increased Doppler shift as the viewing angle decreases during the outburst stage. The overall pattern of Stokes parameter variations agrees with a model of a radiating blob or shock wave that moves along a helical path down the jet., Comment: 11 pages, 14 figures, accepted in MNRAS

Published
2016
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14. Long-term multi-wavelength variability and correlation study of Markarian 421 from 2007 to 2009

Author

MAGIC Collaboration, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Banerjee, B., Bangale, P., de Almeida, U. Barres, Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Buson, S., Carosi, A., Chatterjee, A., Clavero, R., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Wilhelmi, E. de Oña, Di Pierro, F., Domínguez, A., Prester, D. Dominis, Dorner, D., Doro, M., Einecke, S., Glawion, D. Eisenacher, Elsaesser, D., Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Terrats, D. Garrido, Gaug, M., Giammaria, P., Godinović, N., Muñoz, A. González, Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hanabata, Y., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Rosillo, M. Nievas, Nilsson, K., Nishijima, K., Noda, K., Nogués, L., Orito, R., Overkemping, A., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes-Fortuny, X., Pedaletti, G., Perri, L., Persic, M., Poutanen, J., Moroni, P. G. Prada, Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Garcia, J. Rodriguez, Saito, T., Satalecka, K., Schultz, C., Schweizer, T., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Verguilov, V., Vovk, I., Ward, J. E., Will, M., Wu, M. H., Zanin, R., Blinov, D. A., Chen, W. P., Efimova, N. V., Forné, E., Grishina, T. S., Hovatta, T., Jordan, B., Kimeridze, G. N., Kopatskaya, E. N., Koptelova, E., Kurtanidze, O. M., Kurtanidze, S. O., Lähteenmaäki, A., Larionov, V. M., Larionova, E. G., Larionova, L. V., Ligustri, R., Lin, H. C., McBreen, B., Morozova, D. A., Nikolashvili, M. G., Raiteri, C. M., Ros, J. A., Sadun, A. C., Sigua, L. A., Tornikoski, M., Troitsky, I. S., and Villata, M.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We study the multi-band variability and correlations of the TeV blazar Mrk 421 on year time scales, which can bring additional insight on the processes responsible for its broadband emission. We observed Mrk 421 in the very high energy (VHE) gamma-ray range with the Cherenkov telescope MAGIC-I from March 2007 to June 2009 for a total of 96 hours of effective time after quality cuts. The VHE flux variability is quantified with several methods, including the Bayesian Block algorithm, which is applied to data from Cherenkov telescopes for the first time. The 2.3 year long MAGIC light curve is complemented with data from the Swift/BAT and RXTE/ASM satellites and the KVA, GASP-WEBT, OVRO, and Mets\"ahovi telescopes from February 2007 to July 2009, allowing for an excellent characterisation of the multi-band variability and correlations over year time scales. Mrk 421 was found in different gamma-ray emission states during the 2.3 year long observation period. Flares and different levels of variability in the gamma-ray light curve could be identified with the Bayesian Block algorithm. The same behaviour of a quiet and active emission was found in the X-ray light curves measured by Swift/BAT and the RXTE/ASM, with a direct correlation in time. The behaviour of the optical light curve of GASP-WEBT and the radio light curves by OVRO and Mets\"ahovi are different as they show no coincident features with the higher energetic light curves and a less variable emission. The fractional variability is overall increasing with energy. The comparable variability in the X-ray and VHE bands and their direct correlation during both high- and low-activity periods spanning many months show that the electron populations radiating the X-ray and gamma-ray photons are either the same, as expected in the Synchrotron-Self-Compton mechanism, or at least strongly correlated, as expected in electromagnetic cascades., Comment: Corresponding authors: Ann-Kristin Overkemping (ann-kristin.overkemping@tu-dortmund.de), Marina Manganaro (manganaro@iac.es), Diego Tescaro (diego.tescaro@gmail.com), To be published in Astronomy&Astrophysics (A&A), 12 pages, 9 figures

Published
2016
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15. First tests of the applicability of $\gamma$-ray imaging for background discrimination in time-of-flight neutron capture measurements

Author

Magán, D. L. Pérez, Caballero-Ontanaya, L., Domingo-Pardo, C., Agramunt-Ros, J., Albiol, F., Casanovas, A., González, A., Guerrero, C., Lerendegui-Marco, J., Tarifeño-Saldivia, A., and Collaboration, the n_TOF

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

In this work we explore for the first time the applicability of using $\gamma$-ray imaging in neutron capture measurements to identify and suppress spatially localized background. For this aim, a pinhole gamma camera is assembled, tested and characterized in terms of energy and spatial performance. It consists of a monolithic CeBr$_3$ scintillating crystal coupled to a position-sensitive photomultiplier and readout through an integrated circuit AMIC2GR. The pinhole collimator is a massive carven block of lead. A series of dedicated measurements with calibrated sources and with a neutron beam incident on a $^{197}$Au sample have been carried out at n_TOF, achieving an enhancement of a factor of two in the signal-to-background ratio when selecting only those events coming from the direction of the sample., Comment: Preprint submitted to Nucl. Instr. and Meth. A

Published
2015
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16. Unprecedented study of the broadband emission of Mrk 421 during flaring activity in March 2010

Author

The MAGIC Collaboration, Aleksić, J., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., de Almeida, U. Barres, Barrio, J. A., González, J. Becerra, Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Boller, A., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., Wilhelmi, E. de Oña, Mendez, C. Delgado, Prester, D. Dominis, Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Terrats, D. Garrido, Gaug, M., Godinović, N., Muñoz, A. González, Gozzini, S. R., Hadasch, D., Hanabata, Y., Hayashida, M., Herrera, J., Hildebrand, D., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kadenius, V., Kellermann, H., Knoetig, M. L., Kodani, K., Konno, Y., Krause, J., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., López, M., López-Coto, R., López-Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar-Adrover, P., Nakajima, D., Niedzwiecki, A., Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes-Fortuny, X., Persic, M., Moroni, P. G. Prada, Prandini, E., Puljak, I., Reinthal, R., Rhode, W., Ribó, M., Rico, J., Garcia, J. Rodriguez, Rügamer, S., Saito, T., Saito, K., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Sun, S., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Stamatescu, V., Stamerra, A., Steinbring, T., Steinke, B., Storz, J., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Uellenbeck, M., Vogler, P., Zanin, R., Collaboration, The VERITAS, Archambault, S., Archer, A., Beilicke, M., Benbow, W., Berger, K., Bird, R., Biteau, J., Buckley, J. H., Bugaev, V., Cerruti, M., Chen, X., Ciupik, L., Collins-Hughes, E., Cui, W., Eisch, J. D., Falcone, A., Feng, Q., Finley, J. P., Fortin, P., Fortson, L., Furniss, A., Galante, N., Gillanders, G. H., Griffin, S., Gyuk, G., Håkansson, N., Holder, J., Johnson, C. A., Kaaret, P., Kar, P., Kertzman, M., Kieda, D., Lang, M. J., McArthur, S., McCann, A., Meagher, K., Millis, J., Moriarty, P., Ong, R. A., Otte, A. N., Perkins, J. S., Pichel, A., Pohl, M., Popkow, A., Prokoph, H., Pueschel, E., Ragan, K., Reyes, L. C., Reynolds, P. T., Richards, G. T., Roache, E., Rovero, A. C., Sembroski, G. H., Shahinyan, K., Staszak, D., Telezhinsky, I., Tucci, J. V., Tyler, J., Varlotta, A., Wakely, S. P., Welsing, R., Wilhelm, A., Williams, D. A., Collaborators, External, Buson, S., Finke, J., Villata, M., Raiteri, C., Aller, H. D., Aller, M. F., Cesarini, A., Chen, W. P., Gurwell, M. A., Jorstad, S. G., Kimeridze, G. N., Koptelova, E., Kurtanidze, O. M., Kurtanidze, S. O., Lähteenmäki, A., Larionov, V. M., Larionova, E. G., Lin, H. C., McBreen, B., Moody, J. W., Morozova, D. A., Marscher, A. P., Max-Moerbeck, W., Nikolashvili, M. G., Perri, M., Readhead, A. C. S., Richards, J. L., Ros, J. A., Sadun, A. C., Sakamoto, T., Sigua, L. A., Smith, P. S., Tornikoski, M., Troitsky, I. S., Wehrle, A. E., and Jordan, B.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

A flare from the TeV blazar Mrk 421, occurring in March 2010, was observed for 13 consecutive days from radio to very high energy (VHE, E > 100 GeV) gamma-rays with MAGIC, VERITAS, Whipple, FermiLAT, MAXI, RXTE, Swift, GASP-WEBT, and several optical and radio telescopes. We model the day-scale SEDs with one-zone and two-zone synchrotron self-Compton (SSC) models, investigate the physical parameters, and evaluate whether the observed broadband SED variability can be associated to variations in the relativistic particle population. Flux variability was remarkable in the X-ray and VHE bands while it was minor or not significant in the other bands. The one-zone SSC model can describe reasonably well the SED of each day for the 13 consecutive days. This flaring activity is also very well described by a two-zone SSC model, where one zone is responsible for the quiescent emission while the other smaller zone, which is spatially separated from the first one, contributes to the daily-variable emission occurring in X-rays and VHE gamma-rays. Both the one-zone SSC and the two-zone SSC models can describe the daily SEDs via the variation of only four or five model parameters, under the hypothesis that the variability is associated mostly to the underlying particle population. This shows that the particle acceleration and cooling mechanism producing the radiating particles could be the main one responsible for the broadband SED variations during the flaring episodes in blazars. The two-zone SSC model provides a better agreement to the observed SED at the narrow peaks of the low- and high-energy bumps during the highest activity, although the reported one-zone SSC model could be further improved by the variation of the parameters related to the emitting region itself ($\delta$, $B$ and $R$), in addition to the parameters related to the particle population., Comment: Published in A&A, 30 pages, 15 figures, 6 tables. Online-data: multi-wavelength light curves (data in Fig. 1) and broadband spectral energy distributions (the data in Figs. 6, and B1-B4) are available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/578/A22. Corresponding authors: David Paneque (dpaneque@mpp.mpg.de), Shangyu Sun (sysun@mpp.mpg.de), Hajime Takami (takami@post.kek.jp)

Published
2014
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17. The 72-Hour WEBT Microvariability Observation of Blazar S5 0716+714 in 2009

Author

Bhatta, G., Webb, J. R., Hollingsworth, H., Dhalla, S., Khanuja, A., Bachev, R., Blinov, D. A., Bottcher, M., Calle, O. J. A. Bravo, Calcidese, P., Capezzali, D., Carosati, D., Chigladze, R., Collins, A., Coloma, J. M., Efimov, Y., Gupta, A. C., Hu, S-M., Kurtanidze, O., Lamerato, A., Larionov, V. M., Lee, C. -U., Lindfors, E., Murphy, B., Nilsson, K., Ohlert, J. M., Oksanen, A., Paakkonen, P., Pollock, J. T., Rani, B., Reinthal, R., Rodriguez, D., Ros, J. A., Roustazadeh, P., Sagar, R., Sanchez, A., Shastri, P., Sillanpaa, A., Strigachev, A., Takalo, L., Vennes, S., Villata, M., Villforth, C., Wu, J., and Zhou, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Context. The international whole earth blazar telescope (WEBT) consortium planned and carried out three days of intensive micro-variability observations of S5 0716+714 from February 22, 2009 to February 25, 2009. This object was chosen due to its bright apparent magnitude range, its high declination, and its very large duty cycle for micro-variations. Aims. We report here on the long continuous optical micro-variability light curve of 0716+714 obtained during the multi-site observing campaign during which the Blazar showed almost constant variability over a 0.5 magnitude range. The resulting light curve is presented here for the first time. Observations from participating observatories were corrected for instrumental differences and combined to construct the overall smoothed light curve. Methods. Thirty-six observatories in sixteen countries participated in this continuous monitoring program and twenty of them submitted data for compilation into a continuous light curve. The light curve was analyzed using several techniques including Fourier transform, Wavelet and noise analysis techniques. Those results led us to model the light curve by attributing the variations to a series of synchrotron pulses. Results. We have interpreted the observed microvariations in this extended light curve in terms of a new model consisting of individual stochastic pulses due to cells in a turbulent jet which are energized by a passing shock and cool by means of synchrotron emission. We obtained an excellent fit to the 72-hour light curve with the synchrotron pulse model.

Published
2013
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18. Variability of the blazar 4C 38.41 (B3 1633+382) from GHz frequencies to GeV energies

Author

Raiteri, C. M., Villata, M., Smith, P. S., Larionov, V. M., Acosta-Pulido, J. A., Aller, M. F., D'Ammando, F., Gurwell, M. A., Jorstad, S. G., Joshi, M., Kurtanidze, O. M., Lähteenmäki, A., Mirzaqulov, D. O., Agudo, I., Aller, H. D., Arévalo, M. J., Arkharov, A. A., Bach, U., Benítez, E., Berdyugin, A., Blinov, D. A., Blumenthal, K., Buemi, C. S., Bueno, A., Carleton, T. M., Carnerero, M. I., Carosati, D., Casadio, C., Chen, W. P., Di Paola, A., Dolci, M., Efimova, N. V., Ehgamberdiev, Sh. A., Gómez, J. L., Gonzále, A. I., Hagen-Thorn, V. A., Heidt, J., Hiriart, D., Holikov, Sh., Konstantinova, T. S., Kopatskaya, E. N., Koptelova, E., Kurtanidze, S. O., Larionova, E. G., Larionova, L. V., León-Tavares, J., Leto, P., Lin, H. C., Lindfors, E., Marscher, A. P., McHardy, I. M., Molina, S. N., Morozova, D. A., Mujica, R., Nikolashvili, M. G., Nilsson, K., Ovcharov, E. P., Panwar, N., Pasanen, M., Puerto-Gimenez, I., Reinthal, R., Richter, G. M., Ros, J. A., Sakamoto, T., Schwartz, R. D., Sillanpää, A., Smith, N., Takalo, L. O., Tammi, J., Taylor, B., Thum, C., Tornikoski, M., Trigilio, C., Troitsky, I. S., Umana, G., Valcheva, A. T., and Wehrle, A. E.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The quasar-type blazar 4C 38.41 (B3 1633+382) experienced a large outburst in 2011, which was detected throughout the entire electromagnetic spectrum. We present the results of low-energy multifrequency monitoring by the GASP project of the WEBT consortium and collaborators, as well as those of spectropolarimetric/spectrophotometric monitoring at the Steward Observatory. We also analyse high-energy observations of the Swift and Fermi satellites. In the optical-UV band, several results indicate that there is a contribution from a QSO-like emission component, in addition to both variable and polarised jet emission. The unpolarised emission component is likely thermal radiation from the accretion disc that dilutes the jet polarisation. We estimate its brightness to be R(QSO) ~ 17.85 - 18 and derive the intrinsic jet polarisation degree. We find no clear correlation between the optical and radio light curves, while the correlation between the optical and \gamma-ray flux apparently fades in time, likely because of an increasing optical to \gamma-ray flux ratio. As suggested for other blazars, the long-term variability of 4C 38.41 can be interpreted in terms of an inhomogeneous bent jet, where different emitting regions can change their alignment with respect to the line of sight, leading to variations in the Doppler factor \delta. Under the hypothesis that in the period 2008-2011 all the \gamma-ray and optical variability on a one-week timescale were due to changes in \delta, this would range between ~ 7 and ~ 21. If the variability were caused by changes in the viewing angle \theta\ only, then \theta\ would go from ~ 2.6 degr to ~ 5 degr. Variations in the viewing angle would also account for the dependence of the polarisation degree on the source brightness in the framework of a shock-in-jet model., Comment: 19 pages, 23 figures, in press for Astronomy and Astrophysics

Published
2012
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19. Families of piecewise linear maps with constant Lyapunov exponent

Author

Botella-Soler, V., Oteo, J. A., Ros, J., and Glendinning, P.

Subjects
Nonlinear Sciences - Chaotic Dynamics, 37E05, 37B40
Abstract

We consider families of piecewise linear maps in which the moduli of the two slopes take different values. In some parameter regions, despite the variations in the dynamics, the Lyapunov exponent and the topological entropy remain constant. We provide numerical evidence of this fact and we prove it analytically for some special cases. The mechanism is very different from that of the logistic map and we conjecture that the Lyapunov plateaus reflect arithmetic relations between the slopes., Comment: 26 pages, 13 figures

Published
2012

20. Identification of gamma-ray emission from 3C345 and NRAO512

Author

Schinzel, F. K., Sokolovsky, K. V., D'Ammando, F., Burnett, T. H., Max-Moerbeck, W., Cheung, C. C., Fegan, S. J., Casandjian, J. M., Reyes, L. C., Villata, M., Raiteri, C. M., Agudo, I., Calle, O. J. A. Bravo, Carosati, D., Casas, R., Gomez, J. L., Gurwell, M. A., Hsiao, H. Y., Jorstad, S. G., Kimeridze, G., Konstantinova, T. S., Kopatskaya, E. N., Koptelova, E., Kurtanidze, O. M., Kurtanidze, S. O., Larionov, V. M., Larionova, E. G., Larionova, L. V., Marscher, A. P., Morozova, D. A., Nikolashvili, M. G., Roca-Sogorb, M., Ros, J. A., Sigua, L. A., Spiridonova, O., Troitsky, I. S., Vlasyuk, V. V., Lobanov, A. P., and Zensus, J. A.

Subjects
Astrophysics - Cosmology and Extragalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

For more than 15 years, since the days of the Energetic Gamma-Ray Experiment Telescope (EGRET) on board the Compton Gamma-Ray Observatory (CGRO; 1991-2000), it has remained an open question why the prominent blazar 3C 345 was not reliably detected at gamma-ray energies <=20 MeV. Recently a bright gamma-ray source (0FGL J1641.4+3939/1FGL J1642.5+3947), potentially associated with 3C 345, was detected by the Large Area Telescope (LAT) on Fermi. Multiwavelength observations from radio bands to X-rays (mainly GASP-WEBT and Swift) of possible counterparts (3C 345, NRAO 512, B3 1640+396) were combined with 20 months of Fermi-LAT monitoring data (August 2008 - April 2010) to associate and identify the dominating gamma-ray emitting counterpart of 1FGL J1642.5+3947. The source 3C 345 is identified as the main contributor for this gamma-ray emitting region. However, after November 2009 (15 months), a significant excess of photons from the nearby quasar NRAO 512 started to contribute and thereafter was detected with increasing gamma-ray activity, possibly adding flux to 1FGL J1642.5+3947. For the same time period and during the summer of 2010, an increase of radio, optical and X-ray activity of NRAO 512 was observed. No gamma-ray emission from B3 1640+396 was detected., Comment: 11 pages, 5 figures, 5 tables, accepted for publication in A&A

Published
2011
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21. The brightest gamma-ray flaring blazar in the sky: AGILE and multi-wavelength observations of 3C 454.3 during November 2010

Author

Vercellone, S., Striani, E., Vittorini, V., Donnarumma, I., Pacciani, L., Pucella, G., Tavani, M., Raiteri, C. M., Villata, M., Romano, P., Fiocchi, M., Bazzano, A., Bianchin, V., Ferrigno, C., Maraschi, L., Pian, E., Türler, M., Ubertini, P., Bulgarelli, A., Chen, A. W., Giuliani, A., Longo, F., Barbiellini, G., Cardillo, M., Cattaneo, P. W., Del Monte, E., Evangelista, Y., Feroci, M., Ferrari, A., Fuschino, F., Gianotti, F., Giusti, M., Lazzarotto, F., Pellizzoni, A., Piano, G., Pilia, M., Rapisarda, M., Rappoldi, A., Sabatini, S., Soffitta, P., Trifoglio, M., Trois, A., Giommi, P., Lucarelli, F., Pittori, C., Santolamazza, P., Verrecchia, F., Agudo, I., Aller, H. D., Aller, M. F., Arkharov, A. A., Bach, U., Berdyugin, A., Borman, G. A., Chigladze, R., Efimov, Yu. S., Efimova, N. V., Gómez, J. L., Gurwell, M. A., McHardy, I. M., Joshi, M., Kimeridze, G. N., Krajci, T., Kurtanidze, O. M., Kurtanidze, S. O., Larionov, V. M., Lindfors, E., Molina, S. N., Morozova, D. A., Nazarov, S. V., Nikolashvili, M. G., Nilsson, K., Pasanen, M., Reinthal, R., Ros, J. A., Sadun, A. C., Sakamoto, T., Sallum, S., Sergeev, S. G., Schwartz, R. D., Sigua, L. A., Sillanpää, A., Sokolovsky, K. V., Strelnitski, V., Takalo, L., Taylor, B., and Walker, G.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Since 2005, the blazar 3C 454.3 has shown remarkable flaring activity at all frequencies, and during the last four years it has exhibited more than one gamma-ray flare per year, becoming the most active gamma-ray blazar in the sky. We present for the first time the multi-wavelength AGILE, SWIFT, INTEGRAL, and GASP-WEBT data collected in order to explain the extraordinary gamma-ray flare of 3C 454.3 which occurred in November 2010. On 2010 November 20 (MJD 55520), 3C 454.3 reached a peak flux (E>100 MeV) of F_gamma(p) = (6.8+-1.0)E-5 ph/cm2/s on a time scale of about 12 hours, more than a factor of 6 higher than the flux of the brightest steady gamma-ray source, the Vela pulsar, and more than a factor of 3 brighter than its previous super-flare on 2009 December 2-3. The multi-wavelength data make a thorough study of the present event possible: the comparison with the previous outbursts indicates a close similarity to the one that occurred in 2009. By comparing the broadband emission before, during, and after the gamma-ray flare, we find that the radio, optical and X-ray emission varies within a factor 2-3, whereas the gamma-ray flux by a factor of 10. This remarkable behavior is modeled by an external Compton component driven by a substantial local enhancement of soft seed photons., Comment: Accepted for publication in ApJ Letters. 18 Pages, 4 Figures, 1 Table

Published
2011
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22. Coexistence of periods in a bisecting bifurcation

Author

Botella-Soler, V., Oteo, J. A., and Ros, J.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

The inner structure of the attractor appearing when the Varley-Gradwell-Hassell population model bifurcates from regular to chaotic behaviour is studied. By algebraic and geometric arguments the coexistence of a continuum of neutrally stable limit cycles with different periods in the attractor is explained., Comment: 13 pages, 5 figures

Published
2011
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23. Bifurcations in the Lozi map

Author

Botella-Soler, V., Castelo, J. M., Oteo, J. A., and Ros, J.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

We study the presence in the Lozi map of a type of abrupt order-to-order and order-to-chaos transitions which are mediated by an attractor made of a continuum of neutrally stable limit cycles, all with the same period., Comment: 17 pages, 12 figures

Published
2011
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24. Another look at the BL Lacertae flux and spectral variability

Author

Raiteri, C. M., Villata, M., Bruschini, L., Capetti, A., Kurtanidze, O. M., Larionov, V. M., Romano, P., Vercellone, S., Agudo, I., Aller, H. D., Aller, M. F., Arkharov, A. A., Bach, U., Berdyugin, A., Blinov, D. A., Böttcher, M., Buemi, C. S., Calcidese, P., Carosati, D., Casas, R., Chen, W. -P., Coloma, J., Diltz, C., Di Paola, A., Dolci, M., Efimova, N. V., Forné, E., Gómez, J. L., Gurwell, M. A., Hakola, A., Hovatta, T., Hsiao, H. Y., Jordan, B., Jorstad, S. G., Koptelova, E., Kurtanidze, S. O., Lähteenmäki, A., Larionova, E. G., Leto, P., Lindfors, E., Ligustri, R., Marscher, A. P., Morozova, D. A., Nikolashvili, M. G., Nilsson, K., Ros, J. A., Roustazadeh, P., Sadun, A. C., Sillanpää, A., Sainio, J., Takalo, L. O., Tornikoski, M., Trigilio, C., Troitsky, I. S., and Umana, G.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope (WEBT) monitored BL Lacertae in 2008-2009 at radio, near-IR, and optical frequencies. During this period, high-energy observations were performed by XMM-Newton, Swift, and Fermi. We analyse these data with particular attention to the calibration of Swift UV data, and apply a helical jet model to interpret the source broad-band variability. The GASP-WEBT observations show an optical flare in 2008 February-March, and oscillations of several tenths of mag on a few-day time scale afterwards. The radio flux is only mildly variable. The UV data from both XMM-Newton and Swift seem to confirm a UV excess that is likely caused by thermal emission from the accretion disc. The X-ray data from XMM-Newton indicate a strongly concave spectrum, as well as moderate flux variability on an hour time scale. The Swift X-ray data reveal fast (interday) flux changes, not correlated with those observed at lower energies. We compare the spectral energy distribution (SED) corresponding to the 2008 low-brightness state, which was characterised by a synchrotron dominance, to the 1997 outburst state, where the inverse-Compton emission was prevailing. A fit with an inhomogeneous helical jet model suggests that two synchrotron components are at work with their self inverse-Compton emission. Most likely, they represent the radiation from two distinct emitting regions in the jet. We show that the difference between the source SEDs in 2008 and 1997 can be explained in terms of pure geometrical variations. The outburst state occurred when the jet-emitting regions were better aligned with the line of sight, producing an increase of the Doppler beaming factor. Our analysis demonstrates that the jet geometry can play an extremely important role in the BL Lacertae flux and spectral variability., Comment: 12 pages, 10 figures, accepted for publication in A&A

Published
2010
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25. Dynamics of a map with power-law tail

Author

Botella-Soler, V., Oteo, J. A., and Ros, J.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

We analyze a one-dimensional piecewise continuous discrete model proposed originally in studies on population ecology. The map is composed of a linear part and a power-law decreasing piece, and has three parameters. The system presents both regular and chaotic behavior. We study numerically and, in part, analytically different bifurcation structures. Particularly interesting is the description of the abrupt transition order-to-chaos mediated by an attractor made of an infinite number of limit cycles with only a finite number of different periods. It is shown that the power-law piece in the map is at the origin of this type of bifurcation. The system exhibits interior crises and crisis-induced intermittency., Comment: 28 pages, 17 figures

Published
2008
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26. The Magnus expansion and some of its applications

Author

Blanes, S., Casas, F., Oteo, J. A., and Ros, J.

Subjects
Mathematical Physics
Abstract

Approximate resolution of linear systems of differential equations with varying coefficients is a recurrent problem shared by a number of scientific and engineering areas, ranging from Quantum Mechanics to Control Theory. When formulated in operator or matrix form, the Magnus expansion furnishes an elegant setting to built up approximate exponential representations of the solution of the system. It provides a power series expansion for the corresponding exponent and is sometimes referred to as Time-Dependent Exponential Perturbation Theory. Every Magnus approximant corresponds in Perturbation Theory to a partial re-summation of infinite terms with the important additional property of preserving at any order certain symmetries of the exact solution. The goal of this review is threefold. First, to collect a number of developments scattered through half a century of scientific literature on Magnus expansion. They concern the methods for the generation of terms in the expansion, estimates of the radius of convergence of the series, generalizations and related non-perturbative expansions. Second, to provide a bridge with its implementation as generator of especial purpose numerical integration methods, a field of intense activity during the last decade. Third, to illustrate with examples the kind of results one can expect from Magnus expansion in comparison with those from both perturbative schemes and standard numerical integrators. We buttress this issue with a revision of the wide range of physical applications found by Magnus expansion in the literature., Comment: Report on the Magnus expansion for differential equations and its applications to several physical problems

Published
2008
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27. Ten-year optical monitoring of PKS 0735+178: historical comparison, multiband behaviour and variability timescales

Author

Ciprini, S., Takalo, L. O., Tosti, G., Raiteri, C. M., Fiorucci, M., Villata, M., Nucciarelli, G., Lanteri, L., Nilsson, K., and Ros, J. A.

Subjects
Astrophysics
Abstract

New data and results on the optical behaviour of the blazar PKS 0735+178 are presented. In addition the whole historical light curve, and a new photometric calibration of comparison stars are reported. Optical spectral indexes are calculated and studied on years scales, while several methods for time-series analysis are applied to the whole historical series and to each observing season of our data set. This allowed to search and identify optical variability modes, characteristic timescales and the signal power spectrum over 3 decades in time. In the last 10 years the optical flux of PKS 0735+178 exhibited a rather achromatic long-term behaviour and a variability mode resembling the shot-noise. The brightness level was in an intermediate/low state with a mild flaring activity and a superimposition/succession of rapid and slower flares, with no extraordinary/isolated outbursts but, at any rate, characterized by 1 major active phase in 2001. Several mid-term scales (days, weeks) were found, the more common falling into values of about 27-28 days, 50-56 days and 76-79 days. The rapid variability in the historical curve appear to be modulated by a general, slower and rather oscillating trend, where typical timescales of about 4.5, 8.5 and 11-13 years can be identified. This spectral and temporal analysis, accompanying our data publication, suggests the occurrence of distinctive variability signatures at days/weeks scales, that can likely be of transitory nature. On the other hand the possible pseudo-cyclical or multi-component modulations at long times could be more stable, recurrent and correlated to the bimodal radio flux behaviour and the twisted radio structure observed by many years in this blazar., Comment: 21 pages, 13 figures, 3 tables. Typeset with a LaTex2e-AMSLaTex code prepared by the author (using AA vers. 6.1, June 2006, class, and natbib, hyperref, graphicx, packages). Accepted for publication in Astronomy & Astrophysics

Published
2007
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28. Multi-frequency monitoring of gamma-ray loud blazars: I. Light curves and spectral energy distributions

Author

Bach, U., Raiteri, C. M., Villata, M., Fuhrmann, L., Buemi, C. S., Larionov, V. M., Leto, P., Arkharov, A. A., Coloma, J. M., Di Paola, A., Dolci, M., Efimova, N., Forne, E., Ibrahimov, M. A., Hagen-Thorn, V., Konstantinova, T., Kopatskaya, E., Lanteri, L., Kurtanidze, O. M., Maccaferri, G., Nikolashvili, M. G., Orlati, A., Ros, J. A., Tosti, G., Trigilio, C., and Umana, G.

Subjects
Astrophysics
Abstract

Context: Being dominated by non-thermal emission from aligned relativistic jets, blazars allow us to elucidate the physics of extragalactic jets, and, ltimately, how the energy is extracted from the central black hole in radio-loud active galactic nuclei. Aims: Crucial information is provided by broad-band spectral energy distributions (SEDs), their trends with luminosity and correlated multi-frequency variability. With this study we plan to obtain a database of contemporaneous radio-to-optical spectra of a sample of blazars, which are and will be observed by current and future high-energy satellites. Methods: Since December 2004 we are performing a monthly multi-frequency radio monitoring of a sample of 35 blazars at the antennas in Medicina and Noto. Contemporaneous near-IR and optical observations for all our observing epochs are organised. Results: Until June 2006 about 4000 radio measurements and 5500 near-IR and optical measurements were obtained. Most of the sources show significant variability in all observing bands. Here we present the multi-frequency data acquired during the first eighteen months of the project, and construct the SEDs for the best-sampled sources., Comment: 16 pages, 3 large figures, accepted for publication in A&A

Published
2006
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29. A fractal set from the binary reflected Gray code

Author

Oteo, J. A. and Ros, J.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

The permutation associated with the decimal expression of the binary reflected Gray code with $N$ bits is considered. Its cycle structure is studied. Considered as a set of points, its self-similarity is pointed out. As a fractal, it is shown to be the attractor of a IFS. For large values of $N$ the set is examined from the point of view of time series analysis, Comment: 15 pages, 9 figures

Published
2005
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32. A family of complex potentials with real spectrum

Author

Fernandez, F. M., Guardiola, R., Ros, J., and Znojil, M.

Subjects
Quantum Physics
Abstract

We consider a two-parameter non hermitean quantum-mechanical hamiltonian that is invariant under the combined effects of parity and time reversal transformation. Numerical investigation shows that for some values of the potential parameters the hamiltonian operator supports real eigenvalues and localized eigenfunctions. In contrast with other PT symmetric models, which require special integration paths in the complex plane, our model is integrable along a line parallel to the real axis., Comment: Six figures and four tables

Published
1998
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34. Albumin determined by bromocresol green leads to erroneous results in routine evaluation of patients with chronic kidney disease.

Author

Schrojenstein Lantman, M. van, Logt, A. van de, Prudon-Rosmulder, E., Langelaan, M., Demir, A.Y., Kurstjens, S., Horst, Armando van der, Kuypers, A., Greuter, A., Kootstra-Ros, J., Hagen, E. van der, Oostendorp, M., Beer, R. de, Ramakers, C., Bakkeren, D., Lindeboom, F., Wijngaart, D. van de, Thelen, M.H.M., Wetzels, J.F.M., Berkel, M. van, Schrojenstein Lantman, M. van, Logt, A. van de, Prudon-Rosmulder, E., Langelaan, M., Demir, A.Y., Kurstjens, S., Horst, Armando van der, Kuypers, A., Greuter, A., Kootstra-Ros, J., Hagen, E. van der, Oostendorp, M., Beer, R. de, Ramakers, C., Bakkeren, D., Lindeboom, F., Wijngaart, D. van de, Thelen, M.H.M., Wetzels, J.F.M., and Berkel, M. van

Abstract

Contains fulltext : 299626.pdf (Publisher’s version ) (Open Access), OBJECTIVES: Measurement of plasma albumin is pivotal for clinical decision-making in patients with chronic kidney disease (CKD). Routinely used methods as bromocresol green (BCG) and bromocresol purple (BCP) can suffer from aselectivity, but the impact of aselectivity on the accuracy of plasma albumin results of CKD-patients is still unknown. Therefore, we evaluated the performance of BCG-, BCP- and JCTLM-endorsed immunological methods in patients with various stages of CKD. METHODS: We evaluated the performance of commonly used albumin methods in patients with CKD stages G1 through G5, the latter divided in two groups based on whether they received hemodialysis treatment. In total, 163 patient plasma samples were measured at 14 laboratories, on six different BCG and BCP-platforms, and four different immunological platforms. The results were compared with an ERM-DA-470k-corrected nephelometric assay. The implications on outcome is evaluated by the proportion of patient results <38 g/L for the diagnosis of protein energy wasting. RESULTS: Albumin results determined with BCP- and immunological methods showed the best agreement with the target value (92.7 and 86.2 %, respectively vs. 66.7 % for BCG, namely due to overestimation). The relative agreement of each method with the target value was platform-dependent, with larger variability in agreement between platforms noted for BCG and immunological methods (3.2-4.6 and 2.6-5.3 %) as opposed to BCP (0.7-1.5 %). The stage of CKD had similar effects on the variability in agreement for the three method-groups (0.6-1.8 % vs. 0.7-1.5 % vs. 0.4-1.6 %). The differences between methods cause discrepancies in clinical decision-making, as structurally fewer patients were diagnosed with protein energy wasting upon using BCG-based albumin results. CONCLUSIONS: Our study shows that BCP is fit for the intended use to measure plasma albumin levels in CKD patients from all stages, including patients on hemodialysis. In contrast, most BC

Published
2023

35. Spontaneous Subarachnoid Haemorrhage: A Population-Based Study on Epidemiology Trends and Clinical Outcomes in Catalonia (Spain)

Author

Mosteiro, Alejandra, primary, Llull, Laula, additional, Pedrosa, Leire, additional, Amaro, Sergio, additional, Blasco, Jordi, additional, Zattera, Luigi, additional, De Riva, Nicolas, additional, Arikan, Fuat, additional, Gandara, Dario, additional, Villalba, Gloria, additional, Cuadrado, Elisa, additional, Rodríguez-Hernández, Ana, additional, Blanco, Alberto, additional, Muñoz, Fernando, additional, Asencio, Carlos, additional, Romero-Chala, Fabian, additional, Álvarez, Paula, additional, López-Ojeda, Pablo, additional, Chirife, Oscar, additional, Salvat, Mercé, additional, Ros, J., additional, Perez, Natalia, additional, and Torné, Ramon, additional

Published
2023
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36. ESICM LIVES 2016: part two: Milan, Italy. 1–5 October 2016

Author

Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Lazaridis, C., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, D. E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., van den Boogaard, M., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Moore, J., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Randall, D., Adwaney, A., Blunden, M., Prowle, J.R., Kirwan, C. J., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., Girbes, A. R. J., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. J., Boerma, E. C., Rulisek, J., Balik, M., Zacharov, S., Kim, H. S., Jeon, S. J., Namgung, H., Lee, E., Lee, E., Cho, Y. J., Lee, Y. J., Huang, A., Cioccari, L., Luethi, N., Mårtensson, J., Bellomo, R., Forsberg, M., Edman, G., Höjer, J., Forsberg, S., Freile, M. T. Chiquito, Hidalgo, F. N., Molina, J. A. Martinez, Lecumberri, R., Rosselló, A. Figuerola, Travieso, P. Medrano, Leon, G. Tuero, Sanchez, J. Gonzalez, Frias, L. Sahuquillo, Rosello, D. Balsells, Verdejo, J. A. Garcia, Serrano, J. A. Noria, Winterwerp, D., van Galen, T., Vazin, A., Karimzade, I., Zand, A., Ozen, E., Ekemen, S., Akcan, A., Sen, E., Yelken, B. Buyukkidan, Kureshi, N., Fenerty, L., Thibault-Halman, G., Erdogan, M., Walling, S., Green, R. S., Clarke, D. B., Briassoulis, P., Kalimeris, K., Ntzouvani, A., Nomikos, T., Papaparaskeva, K., Politi, E., Kostopanagiotou, G., Crewdson, K., Rehn, M., Weaver, A., Brohi, K., Lockey, D., Wright, S., Thomas, K., Baker, C., Mansfield, L., Stafford, V., Wade, C., Watson, G., Bryant, A., Chadwick, T., Shen, J., Wilkinson, J., Furneval, J., Henderson, A., Hugill, K., Howard, P., Roy, A., Bonner, S., Baudouin, S., Ramírez, C. Sánchez, Escalada, S. Hípola, Viera, M. A. Hernández, Santana, M. Cabrera, Balcázar, L. Caipe, Monroy, N. Sangil, Campelo, F. Artiles, Vázquez, C. F. Lübbe, Santana, P. Saavedra, Santana, S. Ruiz, Carteron, L., Patet, C., Quintard, H., Solari, D., Bouzat, P., Oddo, M., Wollersheim, T., Malleike, J., Haas, K., Carbon, N., Schneider, J., Birchmeier, C., Fielitz, J., Spuler, S., Weber-Carstens, S., Enseñat, L., Pérez-Madrigal, A., Saludes, P., Proença, L., Gruartmoner, G., Espinal, C., Mesquida, J., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Lahmer, T., Mayr, U., Herner, A., Schellnegger, R., Schneider, J., Schmid, R. M., Ayoub, W., Samy, W., Esmat, A., Battah, A., Mukhtar, S., Mongkolpun, W., Cortés, D. Orbegozo, Cordeiro, C. P. R., Vincent, J. L., Creteur, J., Funcke, S., Groesdonk, H., Saugel, B., Wagenpfeil, G., Wagenpfeil, S., Reuter, D. A., Fernandez, M. M., Fernandez, R., Magret, M., González-Castro, A., Bouza, M. T., Ibañez, M., García, C., Balerdi, B., Mas, A., Arauzo, V., Añón, J. M., Ruiz, F., Ferreres, J., Tomás, R., Alabert, M., Tizón, A. I., Altaba, S., Llamas, N., Goligher, E C., Fan, E., Herridge, M., Vorona, S., Sklar, M., Dres, M., Rittayamai, N., Lanys, A., Urrea, C., Tomlinson, G., Reid, W. D., Rubenfeld, G. D., Kavanagh, B. P., Brochard, L. J., Ferguson, N. D., Neto, A. Serpa, de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., Forel, J. M., Rolland-Debord, C., Bureau, C., Poitou, T., Clavel, M., Perbet, S., Terzi, N., Kouatchet, A., Similowski, T., Demoule, A., Hunfeld, N., Trogrlic, Z., Ladage, S., Osse, R. J., Koch, B., Rietdijk, W., Devlin, J., van der Jagt, M., Picetti, E., Ceccarelli, P., Mensi, F., Malchiodi, L., Risolo, S., Rossi, I., Antonini, M. V., Servadei, F., Caspani, M. L., Roquilly, A., Lasocki, S., Seguin, P., Geeraerts, T., Perrigault, P. F., Dahyot-Fizelier, C., Paugam-Burtz, C., Cook, F., Cinotti, R., dit Latte, D. Demeure, Mahe, P. J., Fortuit, C., Feuillet, F., Asehnoune, K., Marzorati, C., Spina, S., Scaravilli, V., Vargiolu, A., Riva, M., Giussani, C., Sganzerla, E., Citerio, G., Barbadillo, S., de Molina, F. J. González, Álvarez-Lerma, F., Rodríguez, A., Zakharkina, T., Martin-Loeches, I., Matamoros, S., Povoa, P., Torres, A., Kastelijn, J., Hofstra, J. J., de Jong, M., Schultz, M., Sterk, P., Artigas, A., Bos, L. J., Moreau, A. S., Martin-Loeches, I., Povoa, P., Salluh, J., Rodriguez, A., Nseir, S., de Jong, E., van Oers, J. A., Beishuizen, A., Girbes, A. R. J., Nijsten, M. W. N., de Lange, D. W., Bonvicini, D., Labate, D., Benacchio, L., Olivieri, A., Pizzirani, E., Lopez-Delgado, J. C., Gonzalez-Romero, M., Fuentes-Mila, V., Berbel-Franco, D., Romera-Peregrina, I., Martinez-Pascual, A., Perez-Sanchez, J., Abellan-Lencina, R., Ávila-Espinoza, R. E., Moreno-Gonzalez, G., Sbraga, F., Griffiths, S., Grocott, M. P. W., Creagh-Brown, B., Doyle, J., Wilkerson, P., Soon, Y., Huddart, S., Dickinson, M., Riga, A., Zuleika, A., Miyamoto, K., Kawazoe, Y., Morimoto, T., Yamamoto, T., Fuke, A., Hashimoto, A., Koami, H., Beppu, S., Katayama, Y., Ito, M., Ohta, Y., Yamamura, H., Rygård, S. L., Holst, L B., Wetterslev, J., Johansson, P. I., Perner, A., Soliman, I. W., de Lange, D. W., van Dijk, D., van Delden, J. J. M., Cremer, O. L., Slooter, A. J. C., Peelen, L. M., McWilliams, D., Snelson, C., Neves, A. Das, Loudet, C. I., Busico, M., Vazquez, D., Villalba, D., Veronesi, M., Lischinsky, A., López, F. J. L., Mori, L. Benito, Plotnikow, G., Díaz, A., Giannasi, S., Hernandez, R., Krzisnik, L., Cecotti, C., Viola, L., Lopez, R., Sottile, J. P., Benavent, G., Estenssoro, E., Chen, C. M., Lai, C. C., Cheng, K. C., Chou, W., Chan, K. S., Roeker, L. E., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Weijs, P. J. M., Mogensen, K. M., Rawn, J. D., Robinson, M. K., Christopher, K. B., Tang, Z., Qiu, C., Ouyang, B., Cai, C., Guan, X., Regueira, T., Cea, L., Carlos, S. Juan, Elisa, B., Puebla, C., Vargas, A., Poulsen, M. K., Thomsen, L. P., Kjærgaard, S., Rees, S. E., Karbing, D. S., Wollersheim, T., Frank, S., Müller, M. C., Carbon, N. M., Skrypnikov, V., Pickerodt, P. A., Falk, R., Mahlau, A., Weber-Carstens, S., Lee, A., Inglis, R., Morgan, R., Barker, G., Kamata, K., Abe, T., Saitoh, D., Tokuda, Y., Green, R. S., Butler, M. B., Erdogan, M., Hwa, H. Tae, Gil, L. Jae, Vaquero, R. Hernández, Rodriguez-Ruiz, E., Lago, A. Lopez, Allut, J. L. Garcia, Gestal, A. Estany, Gonzalez, M. A. Garcia, Thomas-Rüddel, D. O., Schwarzkopf, D., Fleischmann, C., Reinhart, K., Suwanpasu, S., Sattayasomboon, Y., Filho, N. M. Filgueiras, Oliveira, J. C. A., Ballalai, C. S., De Lucia, C. V., Araponga, G. P., Veiga, L. N., Silva, C. S., Garrido, M. E., Ramos, B. B., Ricaldi, E. F., Gomes, S. S., Gemmell, L., MacKay, A., Wright, C., Docking, R. I., Doherty, P., Black, E., Stenhouse, P., Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Yatabe, T., Inoue, S., Sakaguchi, M., Egi, M., Abdelhamid, Y. Ali, Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Hokka, M., Egi, M., Mizobuchi, S., Kar, P., Plummer, M., Abdelhamid, Y. Ali, Giersch, E., Summers, M., Hatzinikolas, S., Heller, S., Chapman, M., Jones, K., Horowitz, M., Deane, A., Schweizer, R., Jacquet-Lagreze, M., Portran, P., Junot, S., Allaouchiche, B., Fellahi, J. L., Guerci, P., Ergin, B., Kapucu, A., Ince, C., Cioccari, L., Luethi, N., Crisman, M., Bellomo, R., Mårtensson, J., Shinotsuka, C. Righy, Fagnoul, D., Brasseur, A., Orbegozo, D., Vincent, J. L., Preiser, J. C., Preiser, J. C., Lheureux, O., Thooft, A., Brimioulle, S., Vincent, J. L., Iwasaka, H., Tahara, S., Nagamine, M., Ichigatani, A., Cabrera, A. Rugerio, Zepeda, E. Monares, Granillo, J. Franco, Sánchez, J. S. Aguirre, Montoya, A. A. Tanaka, Montenegro, A. Pedraza, Blanco, G. A. Gálvez, Robles, C. M. Coronado, Drolz, A., Horvatits, T., Roedl, K., Rutter, K., Kluge, S., Funk, G. C., Schneeweiss, B., Fuhrmann, V., Sabetian, G., Pooresmaeel, F., Zand, F., Ghaffaripour, S., Farbod, A., Tabei, H., Taheri, L., Anandanadesan, R., Metaxa, V., Teixeira, C., Pereira, S. M., Hernández-Marrero, P., Carvalho, A. S., Beckmann, M., Hartog, C. S., Schwarzkopf, D., Raadts, A., Robertsen, A., Førde, R., Skaga, N. O., Helseth, E., Honeybul, S., Ho, K., Lopez, P. Martinez, Gonzalez, M. Nieto, Ortega, P. Nuevo, Sola, E. Camara, Spasova, T., de la Torre-Prados, M. V., Kopecky, O., Rusinova, K., Waldauf, P., Cepeplikova, Z., Balik, M., Domínguez, J. Palamidessi, Almudevar, P. Matia, Carmona, S. Alcántara, Muñoz, J. J. Rubio, Castañeda, D. Palacios, Abellán, A. Naharro, Villamizar, P. Rodríguez, Ramos, J. Veganzones, Pérez, L. Pérez, Lucendo, A. Pérez, Ejarque, M. Camós, Estella, A., Camps, V. Lopez, Martín, M. C., Masnou, N., Barbosa, S., Varela, A., Palma, I., Cristina, L., Nunes, E., Pereira, I., Campello, G., Granja, C., Pande, R., Pandey, M., Varghese, S., Chanu, M., Van Dam, M. J., Ter Braak, E. W. M. T., Estella, A., Gracia, M., Viciana, R., Recuerda, M., Fontaiña, L. Perez, Tharmalingam, B., Kovari, F., Rose, L., Mcginlay, M., Amin, R., Burns, K., Connolly, B., Hart, N., Jouvet, P., Katz, S., Leasa, D., Mawdsley, C., Mcauley, D., Schultz, M., Blackwood, B., Denham, S., Worrall, R., Arshad, M., Isherwood, P., Khadjibaev, A., Sabirov, D., Rosstalnaya, A., Parpibaev, F., Sharipova, V., Blanco, G. A. Galvez, Guzman, C. I. Olvera, Sánchez, J. S. Aguirre, Granillo, J. Franco, Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Shafi, M., Tomar, D. S., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Cha, Y. S., Lee, S. J., Tyagi, N., Rajput, R. K., Taneja, S., Singh, V. K., Sharma, S. C., Mittal, S., Rao, B. K., Ayachi, J., Fraj, N., Romdhani, S., Khedher, A., Meddeb, K., Sma, N., Azouzi, A., Bouneb, R., Chouchene, I., El Ghardallou, M., Boussarsar, M., Jennings, R., Walter, E., Ribeiro, J. M., Moniz, I., Marçal, R., Santos, A. C., Candeias, C., e Silva, Z. Costa, Gomez, S. E. Zamora, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Cuellar, A. I. Vasquez, Mildh, H., Pettilä, V., Korhonen, A. M., Karlsson, S., Ala-Kokko, T., Reinikainen, M., Vaara, S. T., Zaleska-Kociecka, M., Grabowski, M., Dąbrowski, M., Wozniak, S., Piotrowska, K., Banaszewski, M., Imiela, J., Stepinska, J., Pérez, A. González, Ordoñez, P. Florez, Giribet, A., Cuervo, M. A. Alonso, Cuervo, R. Alonso, Esteban, M. A. Rodriguez, Fraile, L. Iglesias, Mittelbrum, C. Ponte, Albaiceta, G. Muñiz, Koeze, J., Keus, F., Dieperink, W., van der Horst, I. C. C., van Meurs, M., Zijlstra, J. G., Roberts, S., Caballero, C. Hernandez, Isgro, G., Hall, D., Beitland, S., Trøseid, A.-M. S., Brusletto, B. S., Waldum-Grevbo, B. E., Berg, J. P., Sunde, K., Huertas, D. García, Manzano, F., Quintana, M. M. Jiménez-, Osuna, A., Santiago-Ruiz, F., Rodríguez-Mejías, C., Wangensteen, R., Jamaati, H. R., Masjedi, M., Zand, F., Hashemian, S. M. R., Sabetian, G., Abbasi, G., Khaloo, V., Tabei, S. H.a., Kafilzadeh, A., Bakhodaei, H. Haddad, Diaz, J. A., Silva, R., Garcia, D. J., Luis, E., Gomez, M. N., Soriano, R., Gonzalez, P. L., Ibrahim, I. A., Rafik, M. M., Al-Ansary, A. M., Algendi, M. A., Ali, A. A., Fuhrmann, V., Roedl, K., Horvatits, T., Drolz, A., Rutter, K., Benten, D., Kluwe, J., Siedler, S., Kluge, S., Adedugbe, I., Bird, G. T., Kennedy, R. M., Sharma, S., Butler, M. B., Yugi, G., Haroon, B. A., Witter, T., Khaliq, W., Singer, M., Havaldar, A. A., Krishna, B., Sriram, S., Espinoza, E. D. Valenzuela, Pozo, M. O., Edul, V. S. Kanoore, Furche, M., Motta, M. F., Vazquez, A. Risso, Birri, P. N. Rubatto, Ince, C., Dubin, A., Dogliotti, A., Ramos, A., Lovesio, C., Delile, E., Nevière, R., Thiébaut, P.-A., Maupoint, J., Mulder, P., Coquerel, D., Renet, S., do Rego, J. C., Rieusset, J., Richard, V., Tamion, F., Khaliq, W., Andreis, D. T., Singer, M., Smit, B., Smulders, Y. M., de Waard, M. C., van Straaten, H. M. Oudemans, Girbes, A. R. J., Eringa, E. C., Man, A. M. E. Spoelstra-de, Alegría, L., Soto, D., Luengo, C., Gomez, J., Jarufe, N., Bruhn, A., Castro, R., Kattan, E., Tapia, P., Rebolledo, R., Achurra, P., Ospina-Tascón, G., Bakker, J., Hernández, G., Bertini, P., Guarracino, F., Baldassarri, R., Pinsky, M. R., Alegría, L., Vera, M., Dreyse, J., Carpio, D., Henriquez, C., Gajardo, D., Bravo, S., Castro, R., Ospina-Tascón, G., Bakker, J., Hernández, G., Kim, S., Lee, M., Park, S. Y., So, S., Lee, H., Kačar, M. B., Kačar, S. M., Uddin, I., Belhaj, A. M., Aydın, M. A., Avsec, D., Kapuağası, A., Kaymak, Ç., Kovach, L., Şencan, İ., Meço, B., Özçelik, M., Ünal, N., Lazaridis, C., Jenni-Moser, B., Jeitziner, M.-M., Galassi, M. S., Sales, F. L., de Moraes, K. C. L., Batista, C. L., Júnior, J. A. de Souza, Marcari, T. B., Lobato, R., Castro, C. S. A. A., de Souza, L. M., Rodrigues, F. F. P., Correa, N. G., Pelegrini, A. M., Eid, R. A. C., Timenetsky, K. T., Cazati, D., Lobato, M., Diniz, P. S., Rocha, L. L., Cavalheiro, A. M., Lucinio, N. M., Santos, E. R., Norrenberg, M., Gleize, A., Preiser, J. C., Simón, I. Fernández, Carmona, S. Alcántara, Valhonrat, I. Lipperheide, Domínguez, J. Palamidessi, Abellán, A. Naharro, Almudévar, P. Matía, Dávila, F., Rubio, J. J., Ramos, A. J., Reina, Á. J. Roldán, López, N. Palomo, Pérez, M. Adriaensens, Apolo, D. X. Cuenca, Villén, L. Martín, López, F. M. Porras, García, I. Palacios, Izurieta, J. R. Naranjo, Guerrero, J. J. Egea, Calvert, S., Quint, M., Adeniji, K., Young, R., Shevill, D. 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Iglesias, Mittelbrum, C. Ponte, Albaiceta, G. Muñiz, Ampatzidou, F., Sileli, M., Kehagioglou, G., Madesis, A., Karaiskos, T., Moursia, C., Maleoglou, H., Leleki, K., Drossos, G., Uz, Z., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Ince, C., De Mol, B., Vicka, V., Gineityte, D., Ringaitiene, D., Norkiene, I., Sipylaite, J., Möller, C., Fleischmann, C., Thomas-Rueddel, D. O., Vlasakov, V., Rochwerg, B., Theurer, P., Gattinoni, L., Reinhart, K., Hartog, C. S., Pérez, A. González, Al Sibai, J. Zanabili, Camblor, P. Martinez, Fernandez, P. Alvarez, Gala, J. M. García, Guisasola, J. Silba, Albaiceta, G. Muñiz, Tamura, T., Yatabe, T., Miyajima, I., Yamashita, K., Yokoyama, M., Ampatzidou, F., Kehagioglou, G., Dalampini, E., Nastou, M., Baddour, A., Ignatiadis, A., Asteri, T., Drossos, G., Hathorn, K. E., Purtle, S. W., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Viana, M. V., Tonietto, T. A., Gross, L. A., Costa, V. L., Tavares, A. L. J., Lisboa, B. O., Moraes, R. B., Vieira, S. R., Viana, L. V., Azevedo, M. J., Ceniccola, G. D., Pequeno, R. S. F., Holanda, T. P., Mendonça, V. S., Araújo, W. M. C., Carvalho, L. S. F., Segaran, E., Vickers, L., Brinchmann, K., Wignall, I., Rubulotta, F., De Brito-Ashurst, I., del Olmo, R., Esteban, M. J., Vaquerizo, C., Carreño, R., Gálvez, V., Kaminsky, G., Nieto, B., Fuentes, M., De la Torre, M. A., Torres, E., Alonso, A., Velayos, C., Saldaña, T., Escribá, A., GRIP, J., Kölegård, R., Sundblad, P., Rooyackers, O., Naser, Ben, Jaziri, F., Jazia, A. Ben, Barghouth, M., Hentati, O., Skouri, W., El Euch, M., Mahfoudhi, M., Turki, S., Abdelghni, K. Ben, Abdallah, Ben, Maha, B. N. M., Cánovas, J., Sotos, F., López, A., Lorente, M., Burruezo, A., Torres, D., Polok, K., Włudarczyk, A., Górka, J., Hałek, A., Musiał, J., Szczeklik, W., Jazia, A. Ben, Jaziri, F., Bargouth, M., Bennasr, M., Turki, S., Abdelghani, K. Ben, Abdallah, T. Ben, de Grooth, H. J., Geenen, I. L., Parienti, J. J., Straaten, H. M. Oudemans-van, Shum, H. P., King, H. S., Chan, K. C., Yan, W. W., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Pedrosa, M. Morales, Gubianas, C. Murcia, Bertolin, C. Fuster, Batllori, N. Vila, Sirvent, J. M., Wykes, K., Jack, J., Morgan, P., Mukhopadhyay, A., Chan, H. Y., Kowitlawakul, Y., Remani, D., Leong, C. S. F., Henry, C. J., Puthucheary, Z. A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Espinoza, E. D. Valenzuela, Welsh, S. P., Motta, M. F., Guerra, E., Zerpa, M. C. l., Zechner, F., Furche, M., Berdaguer, F., Birri, P. N. Rubatto, Risso-Vazquez, A., Dubin, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Sánchez-Hurtado, L. A., Arvizu-Tachiquín, P. C., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Baltazar-Torres, J. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Poulose, V., Morales, M. A. Lopez, Castro, S., Pires, T., Melão, L., Krystopchuk, A., Pereira, I., Granja, C., Taniguchi, L. U., Pires, E. M. C., Vieira, Jr, J. M., Azevedo, L. C. P., Nurses of the Central and General ICUs of Shiraz Namazi Hospital, Sedation an Delirium Group Hospital Universitari de Bellvitge, SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group), for the PRoVENT investigators and the PROVE Network, SEMICYUC/GETGAG Working Group, TAVeM study group, POPC-CB investigators, DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators, GEMINI, Bioethics work group of SEMICYUC, The FINNAKI Study Group, Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group, Renal Transplantation HUVR, GEMINI, EDISVAL Group, EDISVAL Group, PLUG Working group, TAVeM study Group, The FINNAKI Study Group, on behalf of Department of Professional Development, ESICM, Critical Care Research Group, SIRAKI group, and Grupo ESBAGA

Published
2016
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40. Porcelanico Bionictile®: reducción selectiva de NOx ambiental con productos cerámicos esmaltados aditivados con una composición conteniendo dioxido de titanio y potenciadores.

Author

Ros, J. L., Sierra, F., Llabrés, F., Artigas, R., Raya, F., Domínguez, E., and García, H.

Subjects
Photocatalytic activity, NOx, decontamination, bionictile, sustainable ceramic, Fachadas, actividad fotocatalítica, descontaminación, ceramica sostenible, Clay industries. Ceramics. Glass, TP785-869
Abstract

The aim os this work is the obtention of a ceramic panel exposed to the solar illumination, able to redude due to their photocatalytic activity, the level of NOx in urban environments. Like to the nature behaviour the product in named as BIONICTILE®.El trabajo ha consistido en imitar en lo posible a la naturaleza (BIONICA) utilizando como soporte a la cerámica que forma parte de elementos constructivos de exterior expuestos a la iluminación solar. De aquí el nombre de la gama de productos cerámicos que CERACASA propone al final de este estudio, denominados BIONICTILE®. El producto cerámico con actividad fotocatalítica implementado en materiales constructivos sería análogo a crear “bosques de azulejos” en las ciudades que reduzcan la contaminación y ayuden a purificar el aire.

Published
2009

42. Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice

Author

Sanz-Ros J, Romero-Garcia N, Mas-Bargues C, Monleon D, Gordevicius J, Brooke R, Dromant M, Diaz A, Derevyanko A, Guio-Carrion A, Roman-Dominguez A, Ingles M, Blasco M, Horvath S, Vina J, and Borras C

Abstract

Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes associated with aging and frailty are particularly interesting. We treated old animals with small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) of young animals, and we found an improvement in several parameters usually altered with aging, such as motor coordination, grip strength, fatigue resistance, fur regeneration, and renal function, as well as an important decrease in frailty. ADSC-sEVs induced proregenerative effects and a decrease in oxidative stress, inflammation, and senescence markers in muscle and kidney. Moreover, predicted epigenetic age was lower in tissues of old mice treated with ADSC-sEVs and their metabolome changed to a youth-like pattern. Last, we gained some insight into the microRNAs contained in sEVs that might be responsible for the observed effects. We propose that young sEV treatment can promote healthy aging.

Published
2022

43. Lung function and radiological findings 1 year after COVID-19: a prospective follow-up

Author

Tarraso J, Safont B, Carbonell-Asins J, Fernandez-Fabrellas E, Sancho-Chust J, Naval E, Amat B, Herrera S, Ros J, Soler-Cataluna J, Rodriguez-Portal J, Andreu A, Marin M, Rodriguez-Hermosa J, Gonzalez-Villaescusa C, Soriano J, and Signes-Costa J

Subjects
Lung fibrosis, Pulmonary sequelae, COVID 19
Abstract

Background The coronavirus disease (COVID-19) pandemic has already affected more than 400 million people, with increasing numbers of survivors. These data indicate that a myriad of people may be affected by pulmonary sequelae of the infection. The aim of this study was to evaluate pulmonary sequelae in patients with bilateral COVID-19 pneumonia according to severity 1 year after hospital discharge. Methods COVID-FIBROTIC is a multicenter prospective observational cohort study for admitted patients with bilateral COVID-19 pneumonia. Pulmonary functional outcomes and chest computed tomography sequelae were analyzed 12 months after hospital discharge and we classified patients into three groups according to severity. A post hoc analysis model was designed to establish how functional test changed between groups and over time. A multivariable logistic regression model was created to study prognostic factors for lung diffusion impairment and radiological fibrotic-like changes at 12 months. Results Among 488 hospitalized patients with COVID-19 pneumonia, 284 patients had completed the entire evaluation at 12 months. Median age was 60.5 +/- 11.9 and 55.3% were men. We found between-group differences in male sex, length of hospital stay, radiological involvement and inflammatory laboratory parameters. The functional evaluation of pulmonary sequelae showed that severe patients had statistically worse levels of lung diffusion at 2 months but no between group differences were found in subsequent controls. At 12-month follow up, however, we found impaired lung diffusion in 39.8% unrelated to severity. Radiological fibrotic-like changes at 12 months were reported in 22.7% of patients (102/448), only associated with radiological involvement at admission (OR: 1.55, 95% CI 1.06-2.38; p = 0.02) and LDH (OR: 0.99, 95% CI 0.98-0.99; p = 0.046). Conclusion Our data suggest that a significant percentage of individuals would develop pulmonary sequelae after COVID 19 pneumonia, regardless of severity of the acute process. Trial registration clinicaltrials.gov NCT04409275 (June 1, 2020)

Published
2022

46. Circulating HPV DNA as a Biomarker for Pre-Invasive and Early Invasive Cervical Cancer: A Feasibility Study.

Author

Bryan, Stacey J., Lee, Jen, Gunu, Richard, Jones, Allison, Olaitan, Adeola, Rosenthal, Adam N., Cutts, Ros J., Garcia-Murillas, Isaac, Turner, Nick, Lalondrelle, Susan, and Bhide, Shreerang A.

Subjects
PAPILLOMAVIRUSES, PILOT projects, DNA, SEQUENCE analysis, CANCER invasiveness, EARLY detection of cancer, CERVICAL intraepithelial neoplasia, TUMOR classification, PAPILLOMAVIRUS diseases, RESEARCH funding, TUMOR markers, CERVIX uteri tumors, EXTRACELLULAR space, SENSITIVITY & specificity (Statistics), BODY fluid examination, NUCLEIC acids, WOMEN'S health, BLOOD
Abstract

Simple Summary: Over 95% of cervical cancers are caused by the human papilloma virus (HPV). Locally advanced HPV-related cancers release tiny bits of tumour containing HPV-DNA into the blood (cHPV-DNA). The presence of cHPV-DNA in the blood can serve as a potential marker of cancer and should be absent in pre-cancerous conditions (cervical intraepithelial neoplasia (CIN). We have developed an ultra-sensitive and specific test to measure blood cHPV-DNA levels. We performed a feasibility study to confirm our expectation that cHPV-DNA is not found in the blood of patients with CIN but is found in the blood of patients with very early cancers. In this study, we have confirmed that cHPV-DNA is absent in the plasma of women with CIN. In early cervical tumours, there was a low detection rate of cHPV-DNA. Therefore, more sensitive tests are required before cHPV-DNA can be used for the detection of very early cervical cancers. Background: High-risk HPV infection is responsible for >99% of cervix cancers (CC). In persistent infections that lead to cancer, the tumour breaches the basement membrane, releasing HPV-DNA into the bloodstream (cHPV-DNA). A next-generation sequencing assay (NGS) for detection of plasma HPV circulating DNA (cHPV-DNA) has demonstrated high sensitivity and specificity in patients with locally advanced cervix cancers. We hypothesised that cHPV-DNA is detectable in early invasive cervical cancers but not in pre-invasive lesions (CIN). Methods: Blood samples were collected from patients with CIN (n = 52) and FIGO stage 1A-1B CC (n = 12) prior to treatment and at follow-up. DNA extraction from plasma, followed by NGS, was used for the detection of cHPV-DNA. Results: None of the patients with pre-invasive lesions were positive for CHPV-DNA. In invasive tumours, plasma from one patient (10%) reached the threshold of positivity for cHPV-DNA in plasma. Conclusion: Low detection of cHPV-DNA in early CC may be explained by small tumour size, poorer access to lymphatics and circulation, and therefore little shedding of cHPV-DNA in plasma at detectable levels. The detection rate of cHPV-DNA in patients with early invasive cervix cancer using even the most sensitive of currently available technologies lacks adequate sensitivity for clinical utility. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Public health response to two imported, epidemiologically related cases of Lassa fever in the Netherlands (ex Sierra Leone), November 2019

Author

Overbosch, F., Boer, M. de, Veldkamp, K.E., Ellerbroek, P., Bleeker-Rovers, C.P., Goorhuis, B., Vugt, M. van, Eijk, A. van der, Leenstra, T., Khargi, M., Ros, J., Brandwagt, D., Haverkate, M., Swaan, C., Reusken, C., Timen, A., Koopmans, M., Dissel, J. van, Lassa Fever Response Team Netherla, Virology, and Athena Institute

Subjects
Male, medicine.medical_specialty, Infectious Disease Transmission, Patient-to-Professional, Epidemiology, Health Personnel, viruses, medicine.disease_cause, Antiviral Agents, health care workers, Sierra leone, Sierra Leone, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Virology, Environmental health, Health care, Medicine, Humans, Lassa fever, Lassa virus, Netherlands, Cross Infection, Travel, Whole Genome Sequencing, business.industry, Transmission (medicine), Reverse Transcriptase Polymerase Chain Reaction, Public health, the Netherlands, Public Health, Environmental and Occupational Health, virus diseases, medicine.disease, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], public health measures, Female, Contact Tracing, business, Rapid Communication
Abstract

On 20 November 2019, Lassa fever was diagnosed in a physician repatriated from Sierra Leone to the Netherlands. A second physician with suspected Lassa fever, repatriated a few days later from the same healthcare facility, was confirmed infected with Lassa virus on 21 November. Comprehensive contact monitoring involving high- and low-risk contacts proved to be feasible and follow-up of the contacts did not reveal any case of secondary transmission in the Netherlands.

Published
2020
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