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1. [Translated article] Standard and Expanded Series Patch Testing Update by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC)

Author

Navarro-Triviño, F.J., Borrego, L., Silvestre-Salvador, J.F., Mercader-García, P., Giménez-Arnau, A.M., Ortiz-de Frutos, F.J., Sanz-Sánchez, T., Melé-Ninot, G., Sánchez-Gilo, A., Zaragoza-Ninet, V., Serra-Baldrich, E., Miquel-Miquel, J., Córdoba-Guijarro, S., Rodríguez-Serna, M., Ruíz-González, I., Carrascosa-Carrillo, J.M., Gómez-de la Fuente, E., Pastor-Nieto, M.A., Heras-Mendaza, F., González-Pérez, R., Sánchez-Pedreño Guillén, P., Sánchez-Pérez, J., Gatica-Ortega, M.E., Fernández-Redondo, V., Hervella-Garcés, M., Manrique-Martínez, P., Guimaraens-Juanena, D., García-Gavín, J., Giménez-Arnau, E., Figueras-Nart, I., Curto-Barredo, L., and Armario-Hita, J.C.

Published
2024
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2. Actualización de la batería estándar y batería ampliada de pruebas alérgicas de contacto por el Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC)

Author

Navarro-Triviño, F.J., Borrego, L., Silvestre-Salvador, J.F., Mercader-García, P., Giménez-Arnau, A.M., Ortiz-de Frutos, F.J., Sanz-Sánchez, T., Melé-Ninot, G., Sánchez-Gilo, A., Zaragoza-Ninet, V., Serra-Baldrich, E., Miquel-Miquel, J., Córdoba-Guijarro, S., Rodríguez-Serna, M., Ruíz-González, I., Carrascosa-Carrillo, J.M., Gómez-de la Fuente, E., Pastor-Nieto, M.A., Heras-Mendaza, F., González-Pérez, R., Sánchez-Pedreño Guillén, P., Sánchez-Pérez, J., Gatica-Ortega, M.E., Fernández-Redondo, V., Hervella-Garcés, M., Manrique-Martínez, P., Guimaraens-Juanena, D., García-Gavín, J., Giménez-Arnau, E., Figueras-Nart, I., Curto-Barredo, L., and Armario-Hita, J.C.

Published
2024
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3. [Translated article] Epidemiological, Clinical, and Allergic Profile of Psoriatic Patients. Evaluation of the Spanish Registry of Contact Dermatitis and Cutaneous Allergy (REIDAC)

Author

Verdaguer-Faja, J., Borrego, L., Mercader-García, P., González Pérez, R., Córdoba-Guijarro, S., Giménez-Arnau, A.M., Ruiz-González, I., Miquel-Miquel, J., Silvestre, J.F., Ortiz de Frutos, F.J., Tous-Romero, F., Sanz Sánchez, T., Rodríguez-Serna, M., Sánchez-Pérez, J., Serra Baldrich, E., Zaragoza-Ninet, V., Pastor-Nieto, M.A., Gática-Ortega, M.E., Sánchez Gilo, A., Melé-Ninot, G., Sánchez-Pedreño Guillén, P., Munera-Campos, M., Descalzo, M.Á., García-Doval, I., and Carrascosa, J.M.

Published
2024
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4. Perfil epidemiológico, clínico y alérgico en pacientes con psoriasis. Evaluación del Registro Español de Dermatitis de Contacto (REIDAC)

Author

Verdaguer-Faja, J., Borrego, L., Mercader-García, P., González Pérez, R., Córdoba-Guijarro, S., Giménez-Arnau, A.M., Ruiz-González, I., Miquel-Miquel, J., Silvestre, J.F., Ortiz de Frutos, F.J., Tous-Romero, F., Sanz Sánchez, T., Rodríguez-Serna, M., Sánchez-Pérez, J., Serra Baldrich, E., Zaragoza-Ninet, V., Pastor-Nieto, M.A., Gática-Ortega, M.E., Sánchez Gilo, A., Melé-Ninot, G., Sánchez-Pedreño Guillén, P., Munera-Campos, M., Descalzo, M.Á., García-Doval, I., and Carrascosa, J.M.

Published
2024
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5. [Translated article] Drug Survival in Cyclosporine Treatment for Moderate to Severe Atopic Dermatitis: Analysis of the Spanish Atopic Dermatitis Registry (BIOBADATOP)

Author

Couselo-Rodríguez, C., Batalla, A., Carrascosa, J.M., Chicharro, P., González-Quesada, A., de la Cueva, P., Giménez-Arnau, A.M., Gilaberte, Y., Rodríguez-Serna, M., Montero-Vilchez, T., Ruiz-Villaverde, R., Elosua-González, M., Silvestre-Salvador, J.F., Munera-Campos, M., Sánchez-Pérez, J., Carretero, G., Mauleón-Fernández, C., Curto-Barredo, L., Ballano-Ruiz, A., Botella-Estrada, R., Arias-Santiago, S., Navarro-Triviño, F.J., Roustan-Gullón, G., Betlloch, I., del Alcázar, E., Abalde-Pintos, M.T., Suárez-Perez, J., García-Doval, I., Descalzo, M.Á., and Flórez, Á.

Published
2024
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6. [Translated article] Four-year Epidemiological Surveillance of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy: Current Situation and Trends

Author

Tous-Romero, F., Borrego-Hernando, L., García-Doval, I., Mercader-García, P., Silvester-Salvador, J.F., Sánchez-Gilo, A., Sanz-Sánchez, T., Giménez-Arnau, A.M., Zaragoza-Ninet, V., Miquel-Miquel, J., González Pérez, R., Córdoba-Guijarro, S., Carrascosa-Carrillo, J.M., Gática-Ortega, M.E., Ruíz-González, I., Serra-Baldrich, E., Pastor-Nieto, A., Rodríguez-Serna, M., Sánchez-Pérez, J., Melé i Ninot, G., Sánchez-Pedreño Guillén, P., and Ortiz-de Frutos, J.

Published
2024
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7. Vigilancia epidemiológica en los últimos 4 años del Registro Español de Investigación en Dermatitis de Contacto y Alergia Cutánea: situación actual y tendencias

Author

Tous-Romero, F., Borrego-Hernando, L., García-Doval, I., Mercader-García, P., Silvester-Salvador, J.F., Sánchez-Gilo, A., Sanz-Sánchez, T., Giménez-Arnau, A.M., Zaragoza-Ninet, V., Miquel-Miquel, J., González Pérez, R., Córdoba-Guijarro, S., Carrascosa-Carrillo, J.M., Gática-Ortega, M.E., Ruíz-González, I., Serra-Baldrich, E., Pastor-Nieto, A., Rodríguez-Serna, M., Sánchez-Pérez, J., Melé i Ninot, G., Sánchez-Pedreño Guillén, P., and Ortiz-de Frutos, J.

Published
2024
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8. Supervivencia de la ciclosporina en el tratamiento de la dermatitis atópica moderada-grave: Registro Español de Dermatitis Atópica (BIOBADATOP)

Author

Couselo-Rodríguez, C., Batalla, A., Carrascosa, J.M., Chicharro, P., González-Quesada, A., de la Cueva, P., Giménez-Arnau, A.M., Gilaberte, Y., Rodríguez-Serna, M., Montero-Vilchez, T., Ruiz-Villaverde, R., Elosua-González, M., Silvestre-Salvador, J.F., Munera-Campos, M., Sánchez-Pérez, J., Carretero, G., Mauleón-Fernández, C., Curto-Barredo, L., Ballano-Ruiz, A., Botella-Estrada, R., Arias-Santiago, S., Navarro-Triviño, F.J., Roustan-Gullón, G., Betlloch, I., del Alcázar, E., Abalde-Pintos, M.T., Suárez-Perez, J., García-Doval, I., Descalzo, M.Á., and Flórez, Á.

Published
2024
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9. Candidate allergens for inclusion in the Spanish Standard Series based on data from the Spanish Contact Dermatitis Registry

Author

Hernández-Fernández, C.P., Mercader-García, P., Silvestre Salvador, J.F., Sánchez Pérez, J., Fernández Redondo, V., Miquel Miquel, F.J., Ortiz de Frutos, F.J., Gatica Ortega, M.E., Mora Fernández, V., Giménez Arnau, A.M., Zaragoza Ninet, V., González Pérez, R., Sanz Sánchez, T., Pastor Nieto, M.A., Serra Baldrich, E., Córdoba Guijarro, S., Heras Mendaza, F., Ruiz González, I., Rodríguez Serna, M., Hervella Garcés, M., Gallego Descalzo, M.A., García Doval, I., and Borrego Hernando, L.

Published
2021
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10. Vigilancia epidemiológica en los últimos 4 años del Registro Español de Investigación en Dermatitis de Contacto y Alergia Cutánea: situación actual y tendencias

Author

Tous-Romero, F., primary, Borrego-Hernando, L., additional, García-Doval, I., additional, Mercader-García, P., additional, Silvester-Salvador, J.F., additional, Sánchez-Gilo, A., additional, Sanz-Sánchez, T., additional, Giménez-Arnau, A.M., additional, Zaragoza-Ninet, V., additional, Miquel-Miquel, J., additional, González Pérez, R., additional, Córdoba-Guijarro, S., additional, Carrascosa-Carrillo, J.M., additional, Gática-Ortega, M.E., additional, Ruíz-González, I., additional, Serra-Baldrich, E., additional, Pastor-Nieto, A., additional, Rodríguez-Serna, M., additional, Sánchez-Pérez, J., additional, Melé i Ninot, G., additional, Sánchez-Pedreño Guillén, P., additional, and Ortiz-de Frutos, J., additional

Published
2023
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15. BIOBADATOP: Registro Español de Dermatitis Atópica. Descripción y primeros resultados

Author

Munera-Campos, M., primary, Chicharro, P., additional, Gonzalez Quesada, A., additional, Florez Menendez, A., additional, de la Cueva Dovao, P., additional, Gimenez Arnau, AM., additional, Gilaberte Calzada, Y., additional, Rodríguez Serna, M., additional, Montero, T., additional, Silvestre Salvador, JF., additional, Elosua González, M., additional, del Alcazar, E., additional, Santamaría, C., additional, Sánchez-Pérez, J., additional, Carretero Hernández, G., additional, Batalla Cebey, A., additional, Jin Suh Oh, H., additional, Mauleón Fernández, C., additional, Curto Barredo, L., additional, Bertolín, M., additional, Navarro Bielsa, A., additional, Ballano Ruiz, A., additional, Botella Estrada, R., additional, Arias Santiago, S., additional, Betlloch, I., additional, Roustan Gullón, G., additional, Rosell Díaz, A., additional, Descalzo, MÁ., additional, García-Doval, I., additional, and Carrascosa, JM., additional

Published
2023
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16. Perfil epidemiológico, clínico, y alérgico en pacientes con dermatitis atópica y dermatitis de las manos. Evaluación del Registro Español de Dermatitis de Contacto (REIDAC

Author

Dermatología, oftalmología y otorrinolaringología, Dermatologia, oftalmologia eta otorrinolaringologia, Mora-Fernández, V., Mercader Garcia, P., Borrego Hernando, L., González Pérez, Ricardo, Córdoba Guijarro, S., Giménez Arnau, A., Ruiz González, I., Miquel Miquel, F.J., Silvestre Salvador, J.F., Ortiz de Frutos, F.J., Sanz Sanchez, T., Rodríguez Serna, M., Fernández Redondo, V., Sanchez Perez, J., Heras Mendaza, F., Serra Baldrich, E, Zaragoza Ninet, V., Pastor Nieto, M.A., Hervella Garcia, M., Garcia Doval, I., Carrascosa, J.M., Dermatología, oftalmología y otorrinolaringología, Dermatologia, oftalmologia eta otorrinolaringologia, Mora-Fernández, V., Mercader Garcia, P., Borrego Hernando, L., González Pérez, Ricardo, Córdoba Guijarro, S., Giménez Arnau, A., Ruiz González, I., Miquel Miquel, F.J., Silvestre Salvador, J.F., Ortiz de Frutos, F.J., Sanz Sanchez, T., Rodríguez Serna, M., Fernández Redondo, V., Sanchez Perez, J., Heras Mendaza, F., Serra Baldrich, E, Zaragoza Ninet, V., Pastor Nieto, M.A., Hervella Garcia, M., Garcia Doval, I., and Carrascosa, J.M.

Abstract

BACKGROUND: Hand eczema is common in patients with atopic dermatitis (AD), but few studies have described the characteristics of these patients in large, representative populations from different geographic regions and occupational settings. OBJECTIVE: To describe the epidemiological, clinical, and allergy profile of patients with hand eczema who underwent patch testing and compare patients with and without AD. METHODS: Analysis of data from the Spanish Contact Dermatitis Registry, a multicenter registry of patients who undergo patch testing in Spain. RESULTS: We included 1466 patients with hand eczema who were patch tested between January 2018 and June 2020. Those with AD were younger and had had symptoms for longer before testing. They were also more likely to have been exposed to occupational triggers (38% vs 53% for patients without AD). The only profession for which significant differences were found was hairdressing. The most common allergens were nickel sulfate, methylchloroisothiazolinone/methylisothiazolinone, cobalt chloride, potassium dichromate, fragrance mixes I and II, and formaldehyde. The most common diagnoses were allergic contact dermatitis (24% vs 31% in patients with and without AD, P=.0224) and irritant contact dermatitis (18% and 35% respectively, P<.001). CONCLUSIONS: AD is common in patients with predominant hand eczema who undergo patch testing. Patients with hand eczema and AD have different clinical and epidemiological characteristics to hand eczema patients in general and their final diagnosis following patch testing is also different.

Published
2022

17. [Translated article] Epidemiological, Clinical, and Allergy Profile of Patients With Atopic Dermatitis and Hand Eczema: Evaluation of the Spanish Contact Dermatitis Registry (REIDAC)

Author

Mora-Fernández, V., primary, Mercader Garcia, P., additional, Borrego Hernando, L., additional, González Pérez, R., additional, Córdoba Guijarro, S., additional, Giménez Arnau, A., additional, Ruiz González, I., additional, Miquel Miquel, F.J., additional, Silvestre Salvador, J.F., additional, Ortiz de Frutos, F.J., additional, Sanz Sanchez, T., additional, Rodríguez Serna, M., additional, Fernández Redondo, V., additional, Sanchez Perez, J., additional, Heras Mendaza, F., additional, Serra Baldrich, E., additional, Zaragoza Ninet, V., additional, Pastor Nieto, M.A., additional, Hervella Garcia, M., additional, Garcia Doval, I., additional, and Carrascosa, J.M., additional

Published
2022
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18. Perfil epidemiológico, clínico, y alérgico en pacientes con dermatitis atópica y dermatitis de las manos. Evaluación del Registro Español de Dermatitis de Contacto (REIDAC)

Author

Mora-Fernández, V., primary, Mercader Garcia, P., additional, Borrego Hernando, L., additional, González Pérez, R., additional, Córdoba Guijarro, S., additional, Giménez Arnau, A., additional, Ruiz González, I., additional, Miquel Miquel, F.J., additional, Silvestre Salvador, J.F., additional, Ortiz de Frutos, F.J., additional, Sanz Sanchez, T., additional, Rodríguez Serna, M., additional, Fernández Redondo, V., additional, Sanchez Perez, J., additional, Heras Mendaza, F., additional, Serra Baldrich, E., additional, Zaragoza Ninet, V., additional, Pastor Nieto, M.A., additional, Hervella Garcia, M., additional, Garcia Doval, I., additional, and Carrascosa, J.M., additional

Published
2022
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20. Alérgenos candidatos para ser incluidos en la serie estándar española a partir de los datos del Registro Español de Dermatitis de Contacto

Author

Hernández-Fernández, C.P., primary, Mercader-García, P., additional, Silvestre Salvador, J.F., additional, Sánchez Pérez, J., additional, Fernández Redondo, V., additional, Miquel Miquel, F.J., additional, Ortiz de Frutos, F.J., additional, Gatica Ortega, M.E., additional, Mora Fernández, V., additional, Giménez Arnau, A.M., additional, Zaragoza Ninet, V., additional, González Pérez, R., additional, Sanz Sánchez, T., additional, Pastor Nieto, M.A., additional, Serra Baldrich, E., additional, Córdoba Guijarro, S., additional, Heras Mendaza, F., additional, Ruiz González, I., additional, Rodríguez Serna, M., additional, Hervella Garcés, M., additional, Gallego Descalzo, M.Á., additional, García Doval, I., additional, and Borrego Hernando, L., additional

Published
2021
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23. Patch testing with formaldehyde 2% aq. - A multicenter study in Spain

Author

Sanz-Sánchez T, Mercader García P, Silvestre Salvador JF, Heras Mendaza F, Gatica Ortega ME, González Pérez R, Zaragoza Ninet V, Rodríguez Serna M, Hervella Garcés M, Córdoba Guijarro S, Fernandez Redondo V, Borrego L, Sánchez-Pedreño P, and Giménez Arnau AM

Subjects
allergic contact dermatitis, formaldehyde, patch test
Published
2019

24. Towards Personalized Medicine in Melanoma: Implementation of a Clinical Next-Generation Sequencing Panel

Author

de Unamuno Bustos B, Murria Estal R, Pérez Simó G, de Juan Jimenez I, Escutia Muñoz B, Rodríguez Serna M, Alegre de Miquel V, Llavador Ros M, Ballester Sánchez R, Nagore Enguídanos E, Palanca Suela S, and Botella Estrada R

Abstract

Molecular diagnostics are increasingly performed routinely in the diagnosis and management of patients with melanoma due to the development of novel therapies that target specific genetic mutations. The development of next-generation sequencing (NGS) technologies has enabled to sequence multiple cancer-driving genes in a single assay, with improved sensitivity in mutation detection. The main objective of this study was the design and implementation of a melanoma-specific sequencing panel, and the identification of the spectrum of somatic mutations in a series of primary melanoma samples. A custom panel was designed to cover the coding regions of 35 melanoma-related genes. Panel average coverage was 2,575.5 reads per amplicon, with 92,8% of targeted bases covered >= 500x. Deep coverage enabled sensitive discovery of mutations in as low as 0.5% mutant allele frequency. Eighty-five percent (85/100) of the melanomas had at least one somatic mutation. The most prevalent mutated genes were BRAF (50%; 50/199), NRAS (15%; 15/100), PREX2 (14%; 14/100), GRIN2A (13%; 13/100), and ERBB4 (12%; 12/100). Turn-around-time and costs for NGS-based analysis was reduced in comparison to conventional molecular approaches. The results of this study demonstrate the cost-effectiveness and feasibility of a custom-designed targeted NGS panel, and suggest the implementation of targeted NGS into daily routine practice.

Published
2017

27. [Translated article] BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings

Author

Munera-Campos, M., Chicharro, P., Gonzalez Quesada, A., Flórez Menéndez, Á., de la Cueva Dobao, P., Gimenez Arnau, A.M., Gilaberte Calzada, Y., Rodríguez Serna, M., Montero-Vilchez, T., Silvestre, J.F., Elosua-González, M., del Alcázar, E., Santamaría, C., Sánchez-Pérez, J., Carretero Hernández, G., Batalla, A., Jin Suh Oh, H., Mauleón Fernández, C., Curto Barredo, L., Bertolín-Colilla, M., Navarro Bielsa, A., Ballano Ruiz, A., Botella Estrada, R., Arias Santiago, S., Betlloch, I., Roustan Gullón, G., Rosell Díaz, A., Descalzo, M.A., García-Doval, I., and Carrascosa, J.M.

Abstract

[Display omitted]

Published
2023
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29. Four-year Epidemiological Surveillance of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy: Current Situation and Trends.

Author

Tous-Romero F, Borrego-Hernando L, García-Doval I, Mercader-García P, Silvester-Salvador JF, Sánchez-Gilo A, Sanz-Sánchez T, Giménez-Arnau AM, Zaragoza-Ninet V, Miquel-Miquel J, González Pérez R, Córdoba-Guijarro S, Carrascosa-Carrillo JM, Gática-Ortega ME, Ruíz-González I, Serra-Baldrich E, Pastor-Nieto A, Rodríguez-Serna M, Sánchez-Pérez J, Melé I Ninot G, Sánchez-Pedreño Guillén P, and Ortiz-de Frutos J

Subjects
Humans, Thiazoles, Allergens adverse effects, Patch Tests, Retrospective Studies, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact epidemiology, Dermatitis, Allergic Contact etiology, Dermatitis, Atopic
Abstract

Background: The epidemiological surveillance of contact dermatitis is one of the objectives of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. Knowing whether the prevalence of positive tests to the different allergens changes over time is important for this monitoring process., Objectives: To describe the various temporary trends in allergen positivity in the GEIDAC standard series from 2018 through December 31, 2022., Methods: This was a multicenter, observational trial of consecutive patients analyzed via patch tests as part of the study of possible allergic contact dermatitises collected prospectively within the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy. The data was analyzed using 2 statistical tests: one homogeneity test (to describe the changes seen over time) and one trend test (to see whether the changes described followed a linear trend)., Results: A total of 11327 patients were included in the study. Overall, the allergens associated with a highest sensitization were nickel sulfate, methylisothiazolinone, cobalt chloride, methylchloroisothiazolinone/methylisothiazolinone, and fragrance mix i. A statistically significant decrease was found in the percentage of methylisothiazolinone positive tests across the study years with an orderly trend., Conclusions: Although various changes were seen in the sensitizations trends to several allergens of the standard testing, it became obvious that a high sensitization to nickel, methylchloroisothiazolinone/methylisothiazolinone and fragrances mix i remained. Only a significant downward trend was seen for methylisothiazolinone., (Copyright © 2023 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2024
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30. Drug Survival in Cyclosporine Treatment for Moderate to Severe Atopic Dermatitis: Analysis of the Spanish Atopic Dermatitis Registry (BIOBADATOP).

Author

Couselo-Rodríguez C, Batalla A, Carrascosa JM, Chicharro P, González-Quesada A, de la Cueva P, Giménez-Arnau AM, Gilaberte Y, Rodríguez-Serna M, Montero-Vilchez T, Ruiz-Villaverde R, Elosua-González M, Silvestre-Salvador JF, Munera-Campos M, Sánchez-Pérez J, Carretero G, Mauleón-Fernández C, Curto-Barredo L, Ballano-Ruiz A, Botella-Estrada R, Arias-Santiago S, Navarro-Triviño FJ, Roustan-Gullón G, Betlloch I, Del Alcázar E, Abalde-Pintos MT, Suárez-Perez J, García-Doval I, Descalzo MÁ, and Flórez Á

Subjects
Humans, Cyclosporine therapeutic use, Immunosuppressive Agents therapeutic use, Prospective Studies, Registries, Treatment Outcome, Dermatitis, Atopic drug therapy, Psoriasis drug therapy
Abstract

Background: The past 5 years have seen a proliferation of new treatments for atopic dermatitis (AD). We analyzed recent drug survival data for cyclosporine in this setting. Because the Spanish National Healthcare system requires patients with AD to be treated with cyclosporine before they can be prescribed other systemic treatments, drug survival for cyclosporine may be shorter than in other diseases., Material and Method: Multicenter, observational, prospective cohort study using data from the Spanish Atopic Dermatitis Registry (BIOBADATOP). Data from the Spanish Registry of Systemic Treatments in Psoriasis (BIOBADADERM) were used to create a comparison cohort., Results: We analyzed data for 130 patients with AD treated with cyclosporine (median drug survival, 1 year). Median cyclosporine survival in the psoriasis comparison group (150 patients) was 0.37 years. Drug survival was significantly longer in AD than in psoriasis (P<.001)., Conclusion: Drug survival of cyclosporine in the BIOBADATOP registry is similar to that described in other series of patients with AD and longer than that observed in the BIOBADADERM psoriasis registry., (Copyright © 2023 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2024
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32. BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings.

Author

Munera-Campos M, Chicharro P, Gonzalez Quesada A, Flórez Menéndez Á, de la Cueva Dobao P, Gimenez Arnau AM, Gilaberte Calzada Y, Rodríguez Serna M, Montero-Vilchez T, Silvestre JF, Elosua-González M, Del Alcázar E, Santamaría C, Sánchez-Pérez J, Carretero Hernández G, Batalla A, Jin Suh Oh H, Mauleón Fernández C, Curto Barredo L, Bertolín-Colilla M, Navarro Bielsa A, Ballano Ruiz A, Botella Estrada R, Arias Santiago S, Betlloch I, Roustan Gullón G, Rosell Díaz A, Descalzo MA, García-Doval I, and Carrascosa JM

Subjects
Humans, Prospective Studies, Cyclosporine therapeutic use, Administration, Cutaneous, Registries, Treatment Outcome, Severity of Illness Index, Dermatitis, Atopic drug therapy, Dermatitis, Atopic epidemiology
Abstract

Background: In recent years, remarkable improvements in our understanding of atopic dermatitis (AD) have revolutionized treatment perspectives, but access to reliable data from clinical practice is essential., Materials and Method: The Spanish Atopic Dermatitis Registry, BIOBADATOP, is a prospective, multicenter database that collects information on patients of all ages with AD requiring systemic therapy with conventional or novel drugs. We analyzed the registry to describe patient characteristics, diagnoses, treatments, and adverse events (AEs)., Results: We studied data entries for 258 patients who had received 347 systemic treatments for AD. Treatment was discontinued in 29.4% of cases, mostly due to a lack of effectiveness (in 10.7% of cases). A total of 132 AEs were described during follow-up. Eighty-six AEs (65%) were linked to a systemic treatment, most commonly dupilumab (39AEs) and cyclosporine (38AEs). The most common AEs were conjunctivitis (11patients), headache (6), hypertrichosis (5), and nausea (4). There was 1severe AE (acute mastoiditis) associated with cyclosporine., Conclusions: Initial findings on AEs from the Spanish BIOBADATOP registry are limited by short follow-up times precluding comparisons or calculation of crude and adjusted incidence rates. At the time of our analysis, no severe AEs had been reported for novel systemic therapies. BIOBADATOP will help answer questions on the effectiveness and safety of conventional and novel systemic therapies in AD., (Copyright © 2023 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2023
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33. Emicizumab-induced photosensitivity.

Author

Asensi Cantó P, Rodríguez Serna M, Lloret Madrid P, Solís Ruiz J, Cid Haro AR, Bonanad Boix S, and Haya Guaita S

Abstract

Emicizumab constitutes a novel and effective prophylaxis for hemophilia A patients with and without inhibitors. In this case report, we describe an emicizumab-induced photosensitivity that forced permanent sun-exposure suppression. To the best of our knowledge, this side effect had not been communicated until present., Competing Interests: Conflict of Interest None declared., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).)

Published
2022
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34. Epidemiological, Clinical, and Allergy Profile of Patients With Atopic Dermatitis and Hand Eczema: Evaluation of the Spanish Contact Dermatitis Registry (REIDAC).

Author

Mora-Fernández V, Mercader Garcia P, Borrego Hernando L, González Pérez R, Córdoba Guijarro S, Giménez Arnau A, Ruiz González I, Miquel Miquel FJ, Silvestre Salvador JF, Ortiz de Frutos FJ, Sanz Sanchez T, Rodríguez Serna M, Fernández Redondo V, Sanchez Perez J, Heras Mendaza F, Serra Baldrich E, Zaragoza Ninet V, Pastor Nieto MA, Hervella Garcia M, Garcia Doval I, and Carrascosa JM

Subjects
Allergens, Humans, Patch Tests, Registries, Retrospective Studies, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact epidemiology, Dermatitis, Allergic Contact etiology, Dermatitis, Atopic diagnosis, Dermatitis, Atopic epidemiology, Eczema diagnosis, Eczema epidemiology, Hand Dermatoses diagnosis, Hand Dermatoses epidemiology, Hand Dermatoses etiology
Abstract

Background: Hand eczema is common in patients with atopic dermatitis (AD), but few studies have described the characteristics of these patients in large, representative populations from different geographic regions and occupational settings., Objective: To describe the epidemiological, clinical, and allergy profile of patients with hand eczema who underwent patch testing and compare patients with and without AD., Methods: Analysis of data from the Spanish Contact Dermatitis Registry, a multicenter registry of patients who undergo patch testing in Spain., Results: We included 1466 patients with hand eczema who were patch tested between January 2018 and June 2020. Those with AD were younger and had had symptoms for longer before testing. They were also more likely to have been exposed to occupational triggers (38% vs 53% for patients without AD). The only profession for which significant differences were found was hairdressing. The most common allergens were nickel sulfate, methylchloroisothiazolinone/methylisothiazolinone, cobalt chloride, potassium dichromate, fragrance mixes I and II, and formaldehyde. The most common diagnoses were allergic contact dermatitis (24% vs 31% in patients with and without AD, P=.0224) and irritant contact dermatitis (18% and 35% respectively, P<.001)., Conclusions: AD is common in patients with predominant hand eczema who undergo patch testing. Patients with hand eczema and AD have different clinical and epidemiological characteristics to hand eczema patients in general and their final diagnosis following patch testing is also different., (Copyright © 2021 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)

Published
2022
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35. Consensus on hemophilia in Mexico

Author

López-Arroyo JL, Pérez-Zúñiga JM, Merino-Pasaye LE, Saavedra-González A, Alcivar-Cedeño LM, Álvarez-Vera JL, Anaya-Cuellar I, Arana-Luna LL, Ávila-Castro D, Bates-Martín RA, Cesarman-Maus G, Chávez-Aguilar LA, de la Peña-Celaya JA, Espitia-Ríos ME, Estrada-Domínguez P, Fermín-Caminero D, Flores-Patricio W, Chávez JG, García-Lee MT, González-Pérez MDC, González-Rubio MDC, González-Villareal MG, Ramírez-Moreno F, Hernández-Colin AK, Hernández-Ruiz E, Herrera-Olivares W, Leyto-Cruz F, Loera-Fragoso S, Martínez-Ríos A, Miranda-Madrazo MR, Morales-Hernández A, Nava-Villegas L, Orellana-Garibay JJ, Palma-Moreno OG, Paredes-Lozano EP, Peña-Alcántara P, Pérez-Lozano U, Pichardo-Cepín YM, Reynoso-Pérez AC, Rodríguez-Serna M, Rojas-Castillejos F, Romero-Rodelo H, Ruíz-Contreras JI, Segura-García A, Silva-Vera K, Soto-Cisneros PM, Tapia-Enríquez AL, Tavera-Rodríguez MG, Teomitzi-Sánchez Ó, Tepepa-Flores F, Valencia-Rivas MD, Valle-Cárdenas T, Varela-Constantino A, Javier-Morales A, Martínez-Ramírez MA, Tena-Cano S, Terrazas-Marín R, Vilchis-González SP, Villela-Peña A, Mena-Zepeda V, and Ibarra MA

Subjects
Blood Coagulation Factors adverse effects, Blood Coagulation Factors therapeutic use, Diagnosis, Differential, Factor IX analysis, Factor IX immunology, Factor VIII analysis, Factor VIII immunology, Female, Genetic Testing, Hemarthrosis diagnosis, Hemarthrosis etiology, Hemarthrosis therapy, Hemostasis genetics, Humans, Isoantibodies analysis, Life Style, Male, Mexico, Preoperative Care methods, Consensus, Hemophilia A complications, Hemophilia A diagnosis, Hemophilia A genetics, Hemophilia A therapy, Hemophilia B complications, Hemophilia B diagnosis, Hemophilia B genetics, Hemophilia B therapy
Published
2021
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36. Allergic contact dermatitis from cetearyl alcohol in Thrombocid® ointment.

Author

Armengot-Carbo MA, Rodríguez-Serna M, Taberner-Bonastre P, and Miquel-Miquel J

Subjects
Aged, Aged, 80 and over, Female, Humans, Ointments, Patch Tests, Dermatitis, Allergic Contact etiology, Fatty Alcohols adverse effects
Abstract

Thrombocid® ointment (Lacer, Barcelona, Spain) is widely used in Spain and other countries for varicose veins and 22 hematomas. To our knowledge, there are no reported cases of allergic contact dermatitis following its use. Herein we present 23 two cases of allergic contact dermatitis to Thrombocid® ointment, owing to cetearyl alcohol.

Published
2016

38. Treatment of protein contact dermatitis with topical tacrolimus.

Author

Mercader P, de la Cuadra-Oyanguren J, Rodríguez-Serna M, Pitarch-Bort G, and Fortea-Baixauli JM

Subjects
Administration, Topical, Adult, Dermatitis, Allergic Contact etiology, Dermatitis, Occupational etiology, Female, Humans, Dermatitis, Allergic Contact drug therapy, Dermatitis, Occupational drug therapy, Food Handling, Immunosuppressive Agents administration & dosage, Proteins immunology, Tacrolimus administration & dosage
Published
2005
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