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We present a two-dimensional study of the gas distribution, excitation and kinematics of the OH absorber galaxy IRAS 19154+2704 using Gemini GMOS-IFU observations. Its continuum image shows a disturbed morphology indicative of a past or on-going interaction. The ionised gas emission presents two kinematic components: a narrow ($\sigma\lesssim$300 km s$^{-1}$) component that may be tracing the gas orbiting in the galaxy potential and a broad ($\sigma\gtrsim$500 km s$^{-1}$) component which is produced by an Active Galactic Nucleus (AGN) driven outflow, with velocities reaching $-$500 km s$^{-1}$ which may exceed the escape velocity of the galaxy. The emission-line ratios and BPT diagrams confirm that the gas excitation in the inner $\sim$2 kpc is mainly due the AGN, while in regions farther away, a contribution from star formation is observed. We estimate a mass outflow rate of $\dot{M}_{\rm out}=4.0\pm2.6$ M$_\odot$ yr$^{-1}$ at a distance of 850 pc from the nucleus. The corresponding outflow kinetic power $\dot{E}_{\rm out} = (2.5\pm1.6)\times10^{42}$ erg s$^{-1}$, is only $3\times10^{-4}$ L$_{\rm bol}$ (the AGN luminosity), but the large mass-outflow rate, if kept for a $\sim$10 Myr AGN lifecycle, will expel $\approx10^8$ M$_\odot$ in ionised gas alone. This is the 6th of a series of papers in which we have investigated the kinematics of ULIRGS, most of which are interacting galaxies showing OH Megamasers. IRAS19154 shows the strongest signatures of an active AGN, supporting an evolutionary scenario: interactions trigger AGN that fully appear in the most advanced stages of the interaction., Comment: Accepted for publication in MNRAS

The variable continuum emission of an active galactic nucleus (AGN) produces corresponding responses in the broad emission lines, which are modulated by light travel delays, and contain information on the physical properties, structure, and kinematics of the emitting gas region. The reverberation mapping technique, a time series analysis of the driving light curve and response, can recover some of this information, including the size and velocity field of the broad line region (BLR). Here we introduce a new forward-modeling tool, the Broad Emission Line MApping Code (BELMAC), which simulates the velocity-resolved reverberation response of the BLR to any given input light curve by setting up a 3D ensemble of gas clouds for various specified geometries, velocity fields, and cloud properties. In this work, we present numerical approximations to the transfer function by simulating the velocity-resolved responses to a single continuum pulse for sets of models representing a spherical BLR with a radiatively driven outflow and a disk-like BLR with Keplerian rotation. We explore how the structure, velocity field, and other BLR properties affect the transfer function. We calculate the response-weighted time delay (reverberation "lag"), which is considered to be a proxy for the luminosity-weighted radius of the BLR. We investigate the effects of anisotropic cloud emission and matter-bounded (completely ionized) clouds and find the response-weighted delay is only equivalent to the luminosity-weighted radius when clouds emit isotropically and are radiation-bounded (partially ionized). Otherwise, the luminosity-weighted radius can be overestimated by up to a factor of 2.

The rise of globalisation has led to a sharp increase in international trade, with high volumes of containers, goods and items moving across the world. Unfortunately, these trade pathways also facilitate the movement of unwanted pests, weeds, diseases, and pathogens. Each item could contain biosecurity risk material, but it is impractical to inspect every item. Instead, inspection efforts typically focus on high risk items. However, low risk does not imply no risk. It is crucial to monitor the low risk pathways to ensure that they are and remain low risk. To do so, many approaches would seek to estimate the risk to some precision, but the lower the risk, the more samples needed to estimate the risk. On a low-risk pathway that can be afforded more limited inspection resources, it makes more sense to assign fewer samples to the lower risk activities. We approach the problem by introducing two thresholds. Our method focuses on letting us know whether the risk is below certain thresholds, rather than estimating the risk precisely. This method also allows us to detect a significant change in risk. Our approach typically requires less sampling than previous methods, while still providing evidence to regulators to help them efficiently and effectively allocate inspection effort., Comment: 12 + 2 pages, 8 figures, 2 tables

National governments use border information to efficiently manage the biosecurity risk presented by travel and commerce. In the Australian border biosecurity system, data about cargo consignments are collected from records of directions: that is, the records of actions taken by the biosecurity regulator. This data collection is complicated by the way directions for a given entry are recorded. An entry is a collection of import lines where each line is a single type of item or commodity. Analysis is simple when the data are recorded in line mode: the directions are recorded individually for each line. The challenge comes when data are recorded in container mode, because the same direction is recorded against each line in the entry. In other words, if at least one line in an entry has a non-compliant inspection result, then all lines in that entry are recorded as non-compliant. Therefore, container mode data creates a challenge for estimating the probability that certain items are non-compliant, because matching the records of non-compliance to the line information is impossible. We develop a statistical model to use container mode data to help inform biosecurity risk of items. We use asymptotic analysis to estimate the value of container mode data compared to line mode data, do a simulation study to verify that we can accurately estimate parameters in a large dataset, and we apply our methods to a real dataset, for which important information about the risk of non-compliance is recovered using the new model.

The most luminous quasars are created by major, gas-rich mergers and E1821+643, an optically luminous quasar situated at the center of a cool-core cluster, appears to be in the late stages of the post-merger blowout phase. This quasar is also identified as a gravitational recoil candidate, in which the supermassive black hole (SMBH) has received a recoil kick due to anisotropic emission of gravitational waves during the coalescence of a progenitor SMBH binary. We analyze long-slit spectra of the extended, ionized gas surrounding E1821+643 to study its kinematics and ionization. We have identified three kinematically distinct components, which we associate, respectively, with a wide-angle polar wind from the nucleus, kinematically undisturbed gas, and a redshifted arc-like structure of gas, at a distance of 3-4\arcsec~(13-18 kpc) from the nucleus. The latter component coincides with the northern and eastern extremities of an arc of [OIII] emission seen in HST images. This feature could trace a tidal tail originating from a merger with a gas-rich galaxy to the South-East of the nucleus, whose presence has been inferred by Aravena et al. from the detection of CO emission. Alternatively, the arc could be the remnant of a shell of gas swept-up by a powerful quasar wind. The emission line ratios of the extended gas are consistent with photoionization by the quasar, but a contribution from radiative shocks cannot be excluded.

The accurate diagnosis and molecular profiling of colorectal cancers are critical for planning the best treatment options for patients. Microsatellite instability (MSI) or mismatch repair (MMR) status plays a vital role in appropriate treatment selection, has prognostic implications and is used to investigate the possibility of patients having underlying genetic disorders (Lynch syndrome). NICE recommends that all CRC patients should be offered MMR/MSI testing. Immunohistochemistry is commonly used to assess MMR status with subsequent molecular testing performed as required. This incurs significant extra costs and requires additional resources. The introduction of automated methods that can predict MSI or MMR status from a target image could substantially reduce the cost associated with MMR testing. Unlike previous studies on MSI prediction involving training a CNN using coarse labels (MSI vs Microsatellite Stable (MSS)), we have utilised fine-grain MMR labels for training purposes. In this paper, we present our work on predicting MSI status in a two-stage process using a single target slide either stained with CK8/18 or H&E. First, we trained a multi-headed convolutional neural network model where each head was responsible for predicting one of the MMR protein expressions. To this end, we performed the registration of MMR stained slides to the target slide as a pre-processing step. In the second stage, statistical features computed from the MMR prediction maps were used for the final MSI prediction. Our results demonstrated that MSI classification can be improved by incorporating fine-grained MMR labels in comparison to the previous approaches in which only coarse labels were utilised.

We present an analysis of historical multi-wavelength emission of the Changing Look (CL) Active Galactic Nucleus (AGN) in NGC 2992, covering epochs ranging from 1978 to 2021, as well as new X-ray and optical spectra. The galaxy presents multiple Seyfert type transitions from type 2 to intermediate-type, losing and regaining its H$\alpha$ BEL recurrently. In X-rays, the source shows intrinsic variability with the absorption corrected luminosity varying by a factor of $\sim$ 40. We rule out tidal disruption events or variable obscuration as causes of the type transitions and show that the presence and the flux of the broad H$\alpha$ emission line are directly correlated with the 2-10 keV X-ray luminosity (L$_{2-10}$): the component disappears at L$_{2-10} \leq 2.6\times10^{42}$\ergcms, this value translates into an Eddington ratio ($\lambda_{\rm Edd}$) of $\sim$ 1\%. The $\lambda_{\rm Edd}$ in which the BEL transitions occur is the same as the critical value at which there should be a state transition between a radiatively inefficient accretion flow (RIAF) and a thin accretion disk, such similarity suggests that the AGN is operating at the threshold mass accretion rate between the two accretion modes. We find a correlation between the narrow Fe K$\alpha$ flux and $\lambda_{\rm Edd}$, and an anti-correlation between full-width at half maximum of H$\alpha$ BEL and $\lambda_{\rm Edd}$, in agreement with theoretical predictions. Two possible scenarios for type transitions are compatible with our results: either the dimming of the AGN continuum, which reduces the supply of ionising photons available to excite the gas in the Broad Line Region (BLR), or the fading of the BLR structure itself occurs as the low accretion rate is not able to sustain the required cloud flow rate in a disk-wind BLR model., Comment: Accepted for publication at MNRAS

A galaxy merger is expected to cause the formation of a supermassive black hole (SMBH) binary, which itself eventually coalesces through the anisotropic emission of gravitational waves. This may result in the merged SMBH receiving a recoil kick velocity ~100 - 1000 km/s, causing it to oscillate in the gravitational potential of the host galaxy. The luminous quasar E1821+643, identified as an SMBH recoil candidate via spectropolarimetry observations, shows Doppler shifting of the broad emission lines in direct and scattered light, consistent with a relative velocity of 2100 km/s between the quasar nucleus and host galaxy. In this paper, we attempt to detect the expected spatial displacement using a combination of optical spectroastrometry and Hubble Space Telescope (HST) narrow band images. The spectroastrometry reveals a relative spatial displacement between the quasar nucleus and the gas emitting the [OIII]4959,5007 lines of ~130mas (~580pc) to the North-West. Our HST images resolve the [OIII] emission on sub-arcsecond scales, showing that it is asymmetrically distributed, extending to radial distances ~0.5 - 0.6" from the nucleus in a wide arc running from the North-East around to the West. A simulated spectroastrometry observation based on the HST [OIII] image indicates that only a small fraction of the measured displacement can be attributed to the asymmetric [OIII] emission. This displacement therefore appears to be a real spatial offset of the quasar nucleus with respect to the narrow-line region, presumed to be located at the host galaxy center, further supporting the interpretation that a post-merger gravitational recoil of the SMBH has occurred in E1821+643., Comment: 12 pages, 15 figures, Accepted for publication in MNRAS

We present the results of high signal-to-noise ratio VLT spectropolarimetry of a representative sample of 25 bright type 1 AGN at z<0.37, of which nine are radio-loud. The sample covers uniformly the 5100 A optical luminosity at $L_{5100}\sim 10^{44}-10^{46}$ erg s$^{-1}$, and H$\alpha$ width at FWHM$\sim 1000-10,000$~ km/s. We derive the continuum and the H$\alpha$ polarization amplitude, polarization angle, and angle swing across the line, together with the radio properties. We find the following: 1. The broad line region (BLR) and continuum polarization are both produced by a single scattering medium. 2. The scattering medium is equatorial, and at right angle to the system axis. 3. The scattering medium is located at or just outside the BLR. The continuum polarization and the H$\alpha$ polarization angle swing, can both serve as an inclination indicator. The observed line width is found to be affected by inclination, which can lead to an underestimate of the black hole mass by a factor of $\sim 5$ for a close-to face-on view. The line width measured in the polarized flux overcomes the inclination bias, and provides a close-to equatorial view of the BLR in all AGN, which allows to reduce the inclination bias in the BLR based black hole mass estimates., Comment: Accepted for publication in MNRAS