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5 results on '"Robbins, C.M."'

1. A common nonsense mutations in EphB2 is associated with prostate cancer risk in African American men with a positive family history

Author

Kittles, R.A., Baffoe-Bonnie, A.B., Moses, T.Y., Robbins, C.M., Ahaghotu, C., Huusko, P., Pettaway, C., Vijayakumar, S., Bennett, J., Hoke, G., Mason,T., Weinrich, S., Trent, J.M., Collins, F.S., Mousses, S., Bailey-Wilson, J., Furbert-Harris, P., Dunston, G., Powell, I.J., and Carpten, J.D.

Subjects
Prostate cancer -- Risk factors, Prostate cancer -- Genetic aspects, Gene mutations -- Research, Genetic polymorphisms -- Research, Tumor suppressor genes -- Analysis, Health
Published
2006

2. Survey of Ashkenazi Jewish SNPs in a 471 kb region of chromosome 9q31 as compared to the public SNP database (dbSNP)

Author

Gill, S.P., Leyne, M., Mull, J., Cuajungco, M.P., Robbins, C.M., Makalowska, I., Blumenfeld, A., Brownstein, M., Gusella, J.F., and Slaugenhaupt, S.A.

Subjects
Human genetics -- Research, Human chromosome abnormalities -- Research, Genetic disorders -- Research, Genetic polymorphisms -- Demographic aspects, Ashkenazim -- Genetic aspects, Dysautonomia -- Genetic aspects, Familial diseases -- Genetic aspects, Databases -- Evaluation, Ethnic groups -- Genetic aspects, Medical genetics, Biological sciences
Published
2001

4. High frequency of BRAF mutations in nevi

Author

Pollock, P.M., Harper, U.L., Hansen, K.S., Yudt, L.M., Stark, M., Robbins, C.M., Moses, T.Y., Hostetter, G., Wagner, U., Kakareka, J., Salem, G., Pohida, T., Heenan, P., Duray, P., Kallioniemi, O., Hayward, N.K., Trent, J.M., Meltzer, P.S., Pollock, P.M., Harper, U.L., Hansen, K.S., Yudt, L.M., Stark, M., Robbins, C.M., Moses, T.Y., Hostetter, G., Wagner, U., Kakareka, J., Salem, G., Pohida, T., Heenan, P., Duray, P., Kallioniemi, O., Hayward, N.K., Trent, J.M., and Meltzer, P.S.

Abstract

To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected melanoma and nevi samples. We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi. These data suggest that mutational activation of the RAS/RAF/MAPK pathway in nevi is a critical step in the initiation of melanocytic neoplasia but alone is insufficient for melanoma tumorigenesis.

Published
2003

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