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40 results on '"Ricci, Donata"'

3. Impact of tobacco control interventions on smoking initiation, cessation, and prevalence: a systematic review

Author

Bafunno, Daniela, primary, Catino, Annamaria, additional, Lamorgese, Vito, additional, Del Bene, Gabriella, additional, Longo, Vito, additional, Montrone, Michele, additional, Pesola, Francesco, additional, Pizzutilo, Pamela, additional, Cassiano, Sandro, additional, Mastrandrea, Angelica, additional, Ricci, Donata, additional, Petrillo, Patrizia, additional, Varesano, Niccolò, additional, Zacheo, Antonella, additional, and Galetta, Domenico, additional

Published
2020
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11. Antioxidant and antifungal activity of different extracts obtained from aerial parts of Inula crithmoides L

Author

Bucchini, Anahi, Ricci, Donata, Messina, Federica, Marcotullio, Maria Carla, Curini, Massimo, and Giamperi, Laura

Abstract

The total phenolic content, antioxidant and antifungal activities of three Inula crithmoides extracts (n-hexane, methylene chloride and MeOH) were investigated. The methanolic extract showed the highest total phenolic content. In the DPPH assay, the methanolic and hexane extracts exhibited the highest DPPH-radical scavenging activity; in the 5-lipoxygenase assay, the hexane extract showed greater inhibitory effect with an IC50 similar to that of Trolox and ascorbic acid. The antifungal activity of the methanolic extract revealed a higher activity against Phytophtora cryptogea and Alternaria solani.

Published
2015
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12. Chemical composition and “ in vitro ” anti-inflammatory activity of Vitis vinifera L. (var. Sangiovese) tendrils extract

Author

Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Fraternale, Daniele, Rudov, Alexander, Prattichizzo, Francesco, Olivieri, Fabiola, Ricci, Donata, Giacomini, Elisa, Carloni,Silvia, Azzolini, Catia, Gordillo Arrobas, Belén, Jara Palacios, Mª José, Verardo, Giancarlo, Albertini, María Cristina, Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Fraternale, Daniele, Rudov, Alexander, Prattichizzo, Francesco, Olivieri, Fabiola, Ricci, Donata, Giacomini, Elisa, Carloni,Silvia, Azzolini, Catia, Gordillo Arrobas, Belén, Jara Palacios, Mª José, Verardo, Giancarlo, and Albertini, María Cristina

Abstract

Grapevine ( Vitis vinifera L.) is currently used for wine production, herbal medicine and food supplements. In this study we investigated the phenolic composition of grape tendril extract (TVV), because these compounds are prob ably r esponsible for the observed biological effects of TVV. We performed our investigation on cells implicated in the inflammatory process and in vascular damage, such as monocyte (U937) and senescent endothelial (HUVEC) cells. We analysed changes in microRNA (miRNA) expression during a pro-inflammatory condition in LPS (lipopolysaccharide) stimulated cells. MiR-126, defined as angiomiR for its ability in the maintenance of endothelial cell functions, and miR-146a, defined as inflamma-miR, for its ability to down-modulate (NF-kB nuclear factor-kB) pro-inflammatory pathway, were analysed along with their targets.TVV extract (40 g/mL) was able to prevent the LPS stimu- lus and may play an important role in the prevention of endothelial dysfunction when the accumulation of senescent endothelial cells occurs.

Published
2016

39. Cytotoxic activity of essential oils of aerial parts and ripe fruits of Echinophora spinosa (Apiaceae)

Author

Chiara Martinelli, Daniele Fraternale, Donata Ricci, Piero Sestili, Cinzia Calcabrini, Michele Guescini, Fraternale, Daniele, Ricci, Donata, Calcabrini, Cinzia, Guescini, Michele, Martinelli, Chiara, and Sestili, Piero

Subjects
p-Cymene, Cell Survival, Cytotoxicity, Apoptosis, Plant Science, law.invention, Terpene, chemistry.chemical_compound, law, Drug Discovery, Oils, Volatile, Humans, Essential oil, Pharmacology, Apiaceae, Traditional medicine, biology, General Medicine, U937 Cells, biology.organism_classification, Essential oils, Myristicin, Complementary and alternative medicine, chemistry, Fruit, Echinophora, comic_books, Toxicity, comic_books.character, Human
Abstract

The cytotoxic effects of the essential oils obtained from the flowering aerial parts (APO) and ripe fruits (RFO) of Echinophora spinosa L. (Apiaceae) from central Italy toward human U937 promonocytoid cells were studied; the contribution of each of the major constituents to the whole cytotoxic activity of either APO or RFO was also characterized. The major components of APO were beta-phellandrene (34.7%), myristicin (16.5%), p-cymene (16.3%), delta3-carene (12.6%), alpha-pinene (6.7%) and alpha-phellandrene (6.2%); those of RFO p-cymene (50.2%), myristicin (15.3%), alpha-pinene (15.1%) and alpha-phellandrene (8.1%). Both oils tested were toxic to U937 cells, but RFO was much more cytotoxic: indeed, the IC50 values calculated from the linear regression curves of RFO and APO were 14.5 +/- 0.85 and 43.4 +/- 2.81 microg/mL, respectively. alpha-Pinene and alpha-phellandrene were identified as the most toxically relevant constituents: however, they did not completely account for the toxic effects of genuine APO and RFO. Interestingly, we found that p-cymene, although per se devoid of toxicity within the tested range of concentrations, was capable of significantly sensitizing U937 cells to the cytotoxic activity of alpha-pinene and alpha-phellandrene, and that specific mixtures of these three terpenes were as toxic as genuine APO and RFO.

Published
2013

40. Aqueous extract from Vitis vinifera tendrils is able to enrich keratinocyte antioxidant defences

Author

Daniele Fraternale, Marina Dachà, Donata Ricci, Cinzia Calcabrini, Luigi Cucchiarini, Lucia Potenza, Roberta De Bellis, Umberto Mancini, Fraternale, Daniele, De Bellis, Roberta, Calcabrini, Cinzia, Potenza, Lucia, Cucchiarini, Luigi, Mancini, Umberto, Dachà, Marina, and Ricci, Donata

Subjects
Keratinocytes, Vitis vinifera tendrils, Antioxidant, medicine.medical_treatment, antioxidant activity, Plant Science, Reductase, medicine.disease_cause, Antioxidants, chemistry.chemical_compound, Phenols, Antioxidant activity, Drug Discovery, medicine, Tendril, GSH, Humans, Vitis, Vitis vinifera tendril, Cells, Cultured, PMOR, Flavonoids, NCTC 2544, Pharmacology, Vitis vinifera tendrils, antioxidant activity, NCTC 2544, GSH, PMOR, Plant Extracts, Chemistry, Medicine (all), Drug Discovery3003 Pharmaceutical Science, Polyphenols, Water, General Medicine, Glutathione, Complementary and Alternative Medicine2708 Dermatology, medicine.anatomical_structure, Complementary and alternative medicine, Biochemistry, Polyphenol, Keratinocyte, Oxidative stress, Intracellular
Abstract

An aqueous extract of V. vinifera L. tendrils was evaluated for its ability to enrich the antioxidant capacity of cultured cells. The long-time antioxidant capability of the extract was measured by in vitro chemical methods, and its influence on reduced glutathione levels and plasma membrane oxido reductase activity was determined in cultured human keratinocytes (NCTC 2544). Keratinocytes are cells normally exposed to oxidative stress, and for this reason adequately equipped with antioxidant defences. However, it has long been suggested that exogenous antioxidants may play an important role in minimizing the adverse effects of oxidative stress on skin. We demonstrated that V. vinifera tendril aqueous extract was able to increase, in a time- and dose-dependent manner, the reduced glutathione concentration and activity of trans plasma membrane oxido reductase as an indirect evaluation of the intracellular redox status of the cells demonstrating a relevant antioxidant activity of this phytocomplex.

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