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2. Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon

Author

Pathologie patiënten zorg, Pathologie Groep Derksen, Cancer, Gronewold, Malte, Grote, Isabel, Bartels, Stephan, Christgen, Henriette, Kandt, Leonie D., Brito, Maria Jose, Cserni, Gàbor, Daemmrich, Maximilian E., Fogt, Franz, Helmke, Burkhard M., ter Hoeve, Natalie, Lang-Schwarz, Corinna, Vieth, Michael, Wellmann, Axel, Kuehnle, Elna, Kulik, Ulf, Riedel, Gesa, Reineke-Plaass, Tanja, Lehmann, Ulrich, Koorman, Thijs, Derksen, Patrick W.B., Kreipe, Hans, Christgen, Matthias, Pathologie patiënten zorg, Pathologie Groep Derksen, Cancer, Gronewold, Malte, Grote, Isabel, Bartels, Stephan, Christgen, Henriette, Kandt, Leonie D., Brito, Maria Jose, Cserni, Gàbor, Daemmrich, Maximilian E., Fogt, Franz, Helmke, Burkhard M., ter Hoeve, Natalie, Lang-Schwarz, Corinna, Vieth, Michael, Wellmann, Axel, Kuehnle, Elna, Kulik, Ulf, Riedel, Gesa, Reineke-Plaass, Tanja, Lehmann, Ulrich, Koorman, Thijs, Derksen, Patrick W.B., Kreipe, Hans, and Christgen, Matthias

Published
2024

3. Microenvironment‐induced restoration of cohesive growth associated with focal activation of P‐cadherin expression in lobular breast carcinoma metastatic to the colon

Author

Gronewold, Malte, primary, Grote, Isabel, additional, Bartels, Stephan, additional, Christgen, Henriette, additional, Kandt, Leonie D, additional, Brito, Maria Jose, additional, Cserni, Gàbor, additional, Daemmrich, Maximilian E, additional, Fogt, Franz, additional, Helmke, Burkhard M, additional, ter Hoeve, Natalie, additional, Lang‐Schwarz, Corinna, additional, Vieth, Michael, additional, Wellmann, Axel, additional, Kuehnle, Elna, additional, Kulik, Ulf, additional, Riedel, Gesa, additional, Reineke‐Plaass, Tanja, additional, Lehmann, Ulrich, additional, Koorman, Thijs, additional, Derksen, Patrick WB, additional, Kreipe, Hans, additional, and Christgen, Matthias, additional

Published
2024
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6. Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma

Author

Christgen, Matthias, Kandt, Leonie Donata, Antonopoulos, Wiebke, Bartels, Stephan, Van Bockstal, Mieke R., Bredt, Martin, Brito, Maria Jose, Christgen, Henriette, Colpaert, Cecile, Cserni, Bálint, Cserni, Gábor, Daemmrich, Maximilian E., Danebrock, Raihanatou, Dedeurwaerdere, Franceska, van Deurzen, Carolien H.M., Erber, Ramona, Fathke, Christine, Feist, Henning, Fiche, Maryse, Gonzalez, Claudia Aura, ter Hoeve, Natalie D., Kooreman, Loes, Krech, Till, Kristiansen, Glen, Kulka, Janina, Laenger, Florian, Lafos, Marcel, Lehmann, Ulrich, Martin-Martinez, Maria Dolores, Mueller, Sophie, Pelz, Enrico, Raap, Mieke, Ravarino, Alberto, Reineke-Plaass, Tanja, Schaumann, Nora, Schelfhout, Anne Marie, De Schepper, Maxim, Schlue, Jerome, Van de Vijver, Koen, Waelput, Wim, Wellmann, Axel, Graeser, Monika, Gluz, Oleg, Kuemmel, Sherko, Nitz, Ulrike, Harbeck, Nadia, Desmedt, Christine, Floris, Giuseppe, Derksen, Patrick W.B., van Diest, Paul J., Vincent-Salomon, Anne, Kreipe, Hans, Christgen, Matthias, Kandt, Leonie Donata, Antonopoulos, Wiebke, Bartels, Stephan, Van Bockstal, Mieke R., Bredt, Martin, Brito, Maria Jose, Christgen, Henriette, Colpaert, Cecile, Cserni, Bálint, Cserni, Gábor, Daemmrich, Maximilian E., Danebrock, Raihanatou, Dedeurwaerdere, Franceska, van Deurzen, Carolien H.M., Erber, Ramona, Fathke, Christine, Feist, Henning, Fiche, Maryse, Gonzalez, Claudia Aura, ter Hoeve, Natalie D., Kooreman, Loes, Krech, Till, Kristiansen, Glen, Kulka, Janina, Laenger, Florian, Lafos, Marcel, Lehmann, Ulrich, Martin-Martinez, Maria Dolores, Mueller, Sophie, Pelz, Enrico, Raap, Mieke, Ravarino, Alberto, Reineke-Plaass, Tanja, Schaumann, Nora, Schelfhout, Anne Marie, De Schepper, Maxim, Schlue, Jerome, Van de Vijver, Koen, Waelput, Wim, Wellmann, Axel, Graeser, Monika, Gluz, Oleg, Kuemmel, Sherko, Nitz, Ulrike, Harbeck, Nadia, Desmedt, Christine, Floris, Giuseppe, Derksen, Patrick W.B., van Diest, Paul J., Vincent-Salomon, Anne, and Kreipe, Hans

Published
2022

7. Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma

Author

Pathologie Groep Derksen, Cancer, Pathologie, Christgen, Matthias, Kandt, Leonie Donata, Antonopoulos, Wiebke, Bartels, Stephan, Van Bockstal, Mieke R, Bredt, Martin, Brito, Maria Jose, Christgen, Henriette, Colpaert, Cecile, Cserni, Bálint, Cserni, Gábor, Daemmrich, Maximilian E, Danebrock, Raihanatou, Dedeurwaerdere, Franceska, van Deurzen, Carolien Hm, Erber, Ramona, Fathke, Christine, Feist, Henning, Fiche, Maryse, Gonzalez, Claudia Aura, Ter Hoeve, Natalie D, Kooreman, Loes, Krech, Till, Kristiansen, Glen, Kulka, Janina, Laenger, Florian, Lafos, Marcel, Lehmann, Ulrich, Martin-Martinez, Maria Dolores, Mueller, Sophie, Pelz, Enrico, Raap, Mieke, Ravarino, Alberto, Reineke-Plaass, Tanja, Schaumann, Nora, Schelfhout, Anne-Marie, De Schepper, Maxim, Schlue, Jerome, Van de Vijver, Koen, Waelput, Wim, Wellmann, Axel, Graeser, Monika, Gluz, Oleg, Kuemmel, Sherko, Nitz, Ulrike, Harbeck, Nadia, Desmedt, Christine, Floris, Giuseppe, Derksen, Patrick Wb, van Diest, Paul J, Vincent-Salomon, Anne, Kreipe, Hans, Pathologie Groep Derksen, Cancer, Pathologie, Christgen, Matthias, Kandt, Leonie Donata, Antonopoulos, Wiebke, Bartels, Stephan, Van Bockstal, Mieke R, Bredt, Martin, Brito, Maria Jose, Christgen, Henriette, Colpaert, Cecile, Cserni, Bálint, Cserni, Gábor, Daemmrich, Maximilian E, Danebrock, Raihanatou, Dedeurwaerdere, Franceska, van Deurzen, Carolien Hm, Erber, Ramona, Fathke, Christine, Feist, Henning, Fiche, Maryse, Gonzalez, Claudia Aura, Ter Hoeve, Natalie D, Kooreman, Loes, Krech, Till, Kristiansen, Glen, Kulka, Janina, Laenger, Florian, Lafos, Marcel, Lehmann, Ulrich, Martin-Martinez, Maria Dolores, Mueller, Sophie, Pelz, Enrico, Raap, Mieke, Ravarino, Alberto, Reineke-Plaass, Tanja, Schaumann, Nora, Schelfhout, Anne-Marie, De Schepper, Maxim, Schlue, Jerome, Van de Vijver, Koen, Waelput, Wim, Wellmann, Axel, Graeser, Monika, Gluz, Oleg, Kuemmel, Sherko, Nitz, Ulrike, Harbeck, Nadia, Desmedt, Christine, Floris, Giuseppe, Derksen, Patrick Wb, van Diest, Paul J, Vincent-Salomon, Anne, and Kreipe, Hans

Published
2022

8. Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma

Author

Christgen, Matthias, primary, Kandt, Leonie Donata, additional, Antonopoulos, Wiebke, additional, Bartels, Stephan, additional, Bockstal, Mieke R, additional, Bredt, Martin, additional, Brito, Maria Jose, additional, Christgen, Henriette, additional, Colpaert, Cecile, additional, Cserni, Bálint, additional, Cserni, Gábor, additional, Daemmrich, Maximilian E, additional, Danebrock, Raihanatou, additional, Dedeurwaerdere, Franceska, additional, Deurzen, Carolien HM, additional, Erber, Ramona, additional, Fathke, Christine, additional, Feist, Henning, additional, Fiche, Maryse, additional, Gonzalez, Claudia Aura, additional, Hoeve, Natalie D, additional, Kooreman, Loes, additional, Krech, Till, additional, Kristiansen, Glen, additional, Kulka, Janina, additional, Laenger, Florian, additional, Lafos, Marcel, additional, Lehmann, Ulrich, additional, Martin‐Martinez, Maria Dolores, additional, Mueller, Sophie, additional, Pelz, Enrico, additional, Raap, Mieke, additional, Ravarino, Alberto, additional, Reineke‐Plaass, Tanja, additional, Schaumann, Nora, additional, Schelfhout, Anne‐Marie, additional, Schepper, Maxim, additional, Schlue, Jerome, additional, Van de Vijver, Koen, additional, Waelput, Wim, additional, Wellmann, Axel, additional, Graeser, Monika, additional, Gluz, Oleg, additional, Kuemmel, Sherko, additional, Nitz, Ulrike, additional, Harbeck, Nadia, additional, Desmedt, Christine, additional, Floris, Giuseppe, additional, Derksen, Patrick WB, additional, Diest, Paul J, additional, Vincent‐Salomon, Anne, additional, and Kreipe, Hans, additional

Published
2021
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10. Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma.

Author

Christgen M, Kandt LD, Antonopoulos W, Bartels S, Van Bockstal MR, Bredt M, Brito MJ, Christgen H, Colpaert C, Cserni B, Cserni G, Daemmrich ME, Danebrock R, Dedeurwaerdere F, van Deurzen CH, Erber R, Fathke C, Feist H, Fiche M, Gonzalez CA, Ter Hoeve ND, Kooreman L, Krech T, Kristiansen G, Kulka J, Laenger F, Lafos M, Lehmann U, Martin-Martinez MD, Mueller S, Pelz E, Raap M, Ravarino A, Reineke-Plaass T, Schaumann N, Schelfhout AM, De Schepper M, Schlue J, Van de Vijver K, Waelput W, Wellmann A, Graeser M, Gluz O, Kuemmel S, Nitz U, Harbeck N, Desmedt C, Floris G, Derksen PW, van Diest PJ, Vincent-Salomon A, and Kreipe H

Subjects
Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, Female, Humans, Immunohistochemistry, Observer Variation, Breast Neoplasms diagnosis, Breast Neoplasms genetics, Breast Neoplasms metabolism, Carcinoma, Lobular diagnosis, Carcinoma, Lobular genetics
Abstract

Invasive lobular breast carcinoma (ILC) is the second most common breast carcinoma (BC) subtype and is mainly driven by loss of E-cadherin expression. Correct classification of BC as ILC is important for patient treatment. This study assessed the degree of agreement among pathologists for the diagnosis of ILC. Two sets of hormone receptor (HR)-positive/HER2-negative BCs were independently reviewed by participating pathologists. In set A (61 cases), participants were provided with hematoxylin/eosin (HE)-stained sections. In set B (62 cases), participants were provided with HE-stained sections and E-cadherin immunohistochemistry (IHC). Tumor characteristics were balanced. Participants classified specimens as non-lobular BC versus mixed BC versus ILC. Pairwise inter-observer agreement and agreement with a pre-defined reference diagnosis were determined with Cohen's kappa statistics. Subtype calls were correlated with molecular features, including CDH1/E-cadherin mutation status. Thirty-five pathologists completed both sets, providing 4,305 subtype calls. Pairwise inter-observer agreement was moderate in set A (median κ = 0.58, interquartile range [IQR]: 0.48-0.66) and substantial in set B (median κ = 0.75, IQR: 0.56-0.86, p < 0.001). Agreement with the reference diagnosis was substantial in set A (median κ = 0.67, IQR: 0.57-0.75) and almost perfect in set B (median κ = 0.86, IQR: 0.73-0.93, p < 0.001). The median frequency of CDH1/E-cadherin mutations in specimens classified as ILC was 65% in set A (IQR: 56-72%) and 73% in set B (IQR: 65-75%, p < 0.001). Cases with variable subtype calls included E-cadherin-positive ILCs harboring CDH1 missense mutations, and E-cadherin-negative ILCs with tubular elements and focal P-cadherin expression. ILCs with trabecular growth pattern were often misclassified as non-lobular BC in set A but not in set B. In conclusion, subtyping of BC as ILC achieves almost perfect agreement with a pre-defined reference standard, if assessment is supported by E-cadherin IHC. CDH1 missense mutations associated with preserved E-cadherin protein expression, E- to P-cadherin switching in ILC with tubular elements, and trabecular ILC were identified as potential sources of discordant classification., (© 2021 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland & John Wiley & Sons, Ltd.)

Published
2022
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