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9 results on '"Reiko Fukamizu"'

1. Supplementary Table 1 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Atsushi Kumanogoh, Isao Tachibana, Kenji Mizuguchi, Takashi Kijima, Yoshito Takeda, Izumi Nagatomo, Koji Inoue, Satoshi Kohmo, Mayumi Suzuki, Kazuyuki Tsujino, Toshiyuki Minami, Ryo Takahashi, Sho Goya, Kana Hasegawa, Ruriko Inoue, Reiko Fukamizu, Haruhiko Hirata, Yozo Kashiwa, Mitsuhiro Yoshida, Tetsuya Kimura, Yi-An Chen, Lokesh P. Tripathi, Hisashi Arase, Hiroshi Kida, and Shoichi Ihara

Abstract

PDF file - 117K, Genes up-regulated (>2.0) in Stat3delta/delta compared with Stat3flox/flox

Published
2023

2. Supplementary Table 3 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Atsushi Kumanogoh, Isao Tachibana, Kenji Mizuguchi, Takashi Kijima, Yoshito Takeda, Izumi Nagatomo, Koji Inoue, Satoshi Kohmo, Mayumi Suzuki, Kazuyuki Tsujino, Toshiyuki Minami, Ryo Takahashi, Sho Goya, Kana Hasegawa, Ruriko Inoue, Reiko Fukamizu, Haruhiko Hirata, Yozo Kashiwa, Mitsuhiro Yoshida, Tetsuya Kimura, Yi-An Chen, Lokesh P. Tripathi, Hisashi Arase, Hiroshi Kida, and Shoichi Ihara

Abstract

PDF file - 63K, Up-regulated PPI network

Published
2023

3. Supplementary Table 2 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Atsushi Kumanogoh, Isao Tachibana, Kenji Mizuguchi, Takashi Kijima, Yoshito Takeda, Izumi Nagatomo, Koji Inoue, Satoshi Kohmo, Mayumi Suzuki, Kazuyuki Tsujino, Toshiyuki Minami, Ryo Takahashi, Sho Goya, Kana Hasegawa, Ruriko Inoue, Reiko Fukamizu, Haruhiko Hirata, Yozo Kashiwa, Mitsuhiro Yoshida, Tetsuya Kimura, Yi-An Chen, Lokesh P. Tripathi, Hisashi Arase, Hiroshi Kida, and Shoichi Ihara

Abstract

PDF file - 126K, Genes down-regulated (

Published
2023

4. Supplementary Table 4 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Atsushi Kumanogoh, Isao Tachibana, Kenji Mizuguchi, Takashi Kijima, Yoshito Takeda, Izumi Nagatomo, Koji Inoue, Satoshi Kohmo, Mayumi Suzuki, Kazuyuki Tsujino, Toshiyuki Minami, Ryo Takahashi, Sho Goya, Kana Hasegawa, Ruriko Inoue, Reiko Fukamizu, Haruhiko Hirata, Yozo Kashiwa, Mitsuhiro Yoshida, Tetsuya Kimura, Yi-An Chen, Lokesh P. Tripathi, Hisashi Arase, Hiroshi Kida, and Shoichi Ihara

Abstract

PDF file - 76K, Enriched KEGG pathway association (p

Published
2023

5. Supplementary Figure 2 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Atsushi Kumanogoh, Isao Tachibana, Kenji Mizuguchi, Takashi Kijima, Yoshito Takeda, Izumi Nagatomo, Koji Inoue, Satoshi Kohmo, Mayumi Suzuki, Kazuyuki Tsujino, Toshiyuki Minami, Ryo Takahashi, Sho Goya, Kana Hasegawa, Ruriko Inoue, Reiko Fukamizu, Haruhiko Hirata, Yozo Kashiwa, Mitsuhiro Yoshida, Tetsuya Kimura, Yi-An Chen, Lokesh P. Tripathi, Hisashi Arase, Hiroshi Kida, and Shoichi Ihara

Abstract

PDF file - 72K, The expression and activation of Stat3 was intact in both myeloid and lymphocyte lineages in Stat3delta/delta mice

Published
2023

6. Supplementary Methods, Figures 1-2 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Atsushi Kumanogoh, Isao Tachibana, Kenji Mizuguchi, Takashi Kijima, Yoshito Takeda, Izumi Nagatomo, Koji Inoue, Satoshi Kohmo, Mayumi Suzuki, Kazuyuki Tsujino, Toshiyuki Minami, Ryo Takahashi, Sho Goya, Kana Hasegawa, Ruriko Inoue, Reiko Fukamizu, Haruhiko Hirata, Yozo Kashiwa, Mitsuhiro Yoshida, Tetsuya Kimura, Yi-An Chen, Lokesh P. Tripathi, Hisashi Arase, Hiroshi Kida, and Shoichi Ihara

Abstract

PDF file - 81K

Published
2023

7. Supplementary Figure 1 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Atsushi Kumanogoh, Isao Tachibana, Kenji Mizuguchi, Takashi Kijima, Yoshito Takeda, Izumi Nagatomo, Koji Inoue, Satoshi Kohmo, Mayumi Suzuki, Kazuyuki Tsujino, Toshiyuki Minami, Ryo Takahashi, Sho Goya, Kana Hasegawa, Ruriko Inoue, Reiko Fukamizu, Haruhiko Hirata, Yozo Kashiwa, Mitsuhiro Yoshida, Tetsuya Kimura, Yi-An Chen, Lokesh P. Tripathi, Hisashi Arase, Hiroshi Kida, and Shoichi Ihara

Abstract

PDF file - 41K, Stat3delta/delta did not acquire large tumors compared to Stat3flox/flox mice

Published
2023

8. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis

Author

Kana Hasegawa, Takashi Kijima, Ruriko Inoue, Kenji Mizuguchi, Koji Inoue, Hiroshi Kida, Ryo Takahashi, Yi-An Chen, Hisashi Arase, Lokesh P. Tripathi, Reiko Fukamizu, Mayumi Suzuki, Yoshito Takeda, Shoichi Ihara, Yozo Kashiwa, Sho Goya, Haruhiko Hirata, Kazuyuki Tsujino, Satoshi Kohmo, Atsushi Kumanogoh, Izumi Nagatomo, Toshiyuki Minami, Isao Tachibana, Mitsuhiro Yoshida, and Tetsuya Kimura

Subjects
STAT3 Transcription Factor, Cancer Research, Chemokine, Lung Neoplasms, Cell, Apoptosis, Biology, medicine.disease_cause, Urethane, Proinflammatory cytokine, Mice, HLA Antigens, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, Animals, Humans, RNA, Messenger, RNA, Small Interfering, STAT3, Cell Proliferation, Mice, Knockout, Cell growth, Monocyte, Killer Cells, Natural, medicine.anatomical_structure, Cell Transformation, Neoplastic, Oncology, Culture Media, Conditioned, Immunology, Cancer research, biology.protein, STAT protein, Carcinogens, Cytokines, RNA Interference, Carcinogenesis
Abstract

Stat3 mediates a complex spectrum of cellular responses, including inflammation, cell proliferation, and apoptosis. Although evidence exists in support of a positive role for Stat3 in cancer, its role has remained somewhat controversial because of insufficient study of how its genetic deletion may affect carcinogenesis in various tissues. In this study, we show using epithelium-specific knockout mice (Stat3Δ/Δ) that Stat3 blunts rather than supports antitumor immunity in carcinogen-induced lung tumorigenesis. Although Stat3Δ/Δ mice did not show any lung defects in terms of proliferation, apoptosis, or angiogenesis, they exhibited reduced urethane-induced tumorigenesis and increased antitumor inflammation and natural killer (NK) cell immunity. Comparative microarray analysis revealed an increase in Stat3Δ/Δ tumors in proinflammatory chemokine production and a decrease in MHC class I antigen expression associated with NK cell recognition. Consistent with these findings, human non–small cell lung cancer (NSCLC) cells in which Stat3 was silenced displayed an enhancement of proinflammatory chemokine production, reduced expression of MHC class I antigen, and increased susceptibility to NK cell–mediated cytotoxicity. In addition, supernatants from Stat3-silenced NSCLC cells promoted monocyte migration. Collectively, our findings argue that Stat3 exerts an inhibitory effect on antitumor NK cell immunity in the setting of carcinogen-induced tumorigenesis. Cancer Res; 72(12); 2990–9. ©2012 AACR.

Published
2012

9. Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models

Author

Masaji Okada, Yoshinobu Okuno, Satomi Hashimoto, Yoko Kita, Noriko Kanamaru, Yasuko Nishida, Yoshie Tsunai, Ruriko Inoue, Hitoshi Nakatani, Reiko Fukamizu, Yumi Namie, Junko Yamada, Kyoko Takao, Ritsuko Asai, Ryoko Asaki, Tetsuo Kase, Yuji Takemoto, Shigeto Yoshida, J.S.M. Peiris, Pei-Jer Chen, Naoki Yamamoto, Tatsuji Nomura, Isao Ishida, Shigeru Morikawa, Masato Tashiro, and Mitsunori Sakatani

Subjects
General Veterinary, General Immunology and Microbiology, fungi, Public Health, Environmental and Occupational Health, Immunization, Passive, Viral Vaccines, Mice, SCID, Human neutralizing antibody against M, Severe Acute Respiratory Syndrome, Article, body regions, Disease Models, Animal, Mice, Infectious Diseases, SCID-PBL/hu, Severe acute respiratory syndrome-related coronavirus, Vaccines, DNA, Molecular Medicine, Animals, Immunotherapy, SARS DNA vaccine, skin and connective tissue diseases, T-Lymphocytes, Cytotoxic
Abstract

We have investigated novel vaccine strategies against severe acute respiratory syndrome (SARS) CoV using cDNA constructs encoding the structural antigens: (S), (M), (E), or (N) protein, derived from SARS CoV. PBL from healthy human volunteers were administered i.p. into IL-2 receptor gamma-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed. These mice can be used to analyze the human immune response in vivo. SARS M DNA vaccine and N DNA vaccine induced human CTL specific for SARS CoV antigens. Alternatively, SARS M DNA vaccines inducing human neutralizing antibodies and human monoclonal antibodies against SARS CoV are now being developed. These results show that these vaccines can induce virus-specific immune responses and should provide a useful tool for development of protective and therapeutic vaccines.

Published
2007

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