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4 results on '"Rawiphan Panpruk"'

1. Correlations between histopathologic findings, serum biomarker levels, and clinical outcomes in Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)

Author

Donlaporn Chuenwipasakul, Chanudda Washrawirul, Rawiphan Panpruk, Jade Wititsuwannakul, Kridipop Charoenchaipiyakul, Supranee Buranapraditkun, Vilavun Puangsricharern, Jettanong Klaewsongkram, and Pawinee Rerknimitr

Subjects
Medicine, Science
Abstract

Abstract Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe dermatological emergencies. The role of cytokines and chemokines in the pathogenesis, progression of the disease, and histopathologic features is not fully elucidated. To address this gap, we conducted a retrospective study examining the associations between 42 serum biomarkers, histopathologic findings, and clinical outcomes in SJS/TEN patients. We reviewed the medical records of 23 patients diagnosed with SJS/TEN. Regarding histopathology, our study did not reveal any significant associations between the degree of epidermal necrosis, dermal mononuclear cell infiltration, and clinical outcomes. However, an intriguing observation was made regarding the degree of dermal infiltration of CD8 + cells, which showed a negative correlation with the severity of acute ocular complications. Notably, serum levels of IFN-γ positively correlated with the number of CD8 + cells in dermal infiltration. Additionally, higher serum levels of myeloperoxidase were associated with greater degrees of epidermal necrosis, while serum Fas ligand and stem cell factor levels were elevated in individuals with increased dermal mononuclear cell infiltration. Furthermore, the levels of S100A8/A9 were significantly correlated with the SCORTEN and mortality rate. These findings provide insights into the intricate pathogenesis of the disease.

Published
2023
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2. Clinical parameters and biological markers associated with acute severe ocular complications in Stevens-Johnson syndrome and toxic epidermal necrolysis

Author

Rawiphan Panpruk, Vilavun Puangsricharern, Jettanong Klaewsongkram, Pawinee Rerknimitr, Thanachaporn Kittipibul, Yuda Chongpison, and Supranee Buranapraditkun

Subjects
Medicine, Science
Abstract

Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions with high mortality rates. Its sequelae, such as blindness, persist even after recovery. Patients with SJS/TEN should be accurately diagnosed and receive appropriate treatment as soon as possible. Therefore, identifying the factors for severity prediction is necessary. We aimed to clarify the clinical parameters and biological markers that can predict acute severe ocular complications (SOCs) in SJS/TEN. This retrospective cross-sectional study enrolled 47 patients with SJS/TEN who were divided into two groups according to ocular severity at acute onset: non-severe ocular complications group (n = 27) and severe ocular complications group (n = 20). Multivariate logistic regression analysis revealed that disease severity (body surface area detachment ≥ 10%) was a predictive factor for acute SOCs, and older age (≥ 60 years) was marginally significantly predictive of SOCs. Serum biomarker levels of S100A8/A9 and granulysin were marginally significant and tended to increase in the SOC group. Therefore, during the early acute stage, focusing on disease severity, patient age, and serum inflammatory biomarkers (S100A8/A9 and granulysin) might help predict SOC progression in patients with SJS/TEN who need prompt and aggressive ocular management to prevent severe ocular sequelae.

Published
2021
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3. Clinical parameters and biological markers associated with acute severe ocular complications in Stevens-Johnson syndrome and toxic epidermal necrolysis

Author

Vilavun Puangsricharern, Rawiphan Panpruk, Jettanong Klaewsongkram, Supranee Buranapraditkun, Yuda Chongpison, Thanachaporn Kittipibul, and Pawinee Rerknimitr

Subjects
Antigens, Differentiation, T-Lymphocyte, Male, medicine.medical_specialty, Eye Diseases, Corneal diseases, Science, macromolecular substances, Predictive markers, Logistic regression, Article, Disease severity, Conjunctival diseases, Internal medicine, Calgranulin B, Humans, Medicine, Calgranulin A, In patient, Granulysin, Immunological disorders, Aged, Retrospective Studies, Body surface area, Multidisciplinary, business.industry, Age Factors, Patient Acuity, Stevens johnson, Middle Aged, medicine.disease, Toxic epidermal necrolysis, Predictive factor, Skin diseases, stomatognathic diseases, Cross-Sectional Studies, Logistic Models, Risk factors, Stevens-Johnson Syndrome, Disease Progression, Female, sense organs, business, Biomarkers
Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions with high mortality rates. Its sequelae, such as blindness, persist even after recovery. Patients with SJS/TEN should be accurately diagnosed and receive appropriate treatment as soon as possible. Therefore, identifying the factors for severity prediction is necessary. We aimed to clarify the clinical parameters and biological markers that can predict acute severe ocular complications (SOCs) in SJS/TEN. This retrospective cross-sectional study enrolled 47 patients with SJS/TEN who were divided into two groups according to ocular severity at acute onset: non-severe ocular complications group (n = 27) and severe ocular complications group (n = 20). Multivariate logistic regression analysis revealed that disease severity (body surface area detachment ≥ 10%) was a predictive factor for acute SOCs, and older age (≥ 60 years) was marginally significantly predictive of SOCs. Serum biomarker levels of S100A8/A9 and granulysin were marginally significant and tended to increase in the SOC group. Therefore, during the early acute stage, focusing on disease severity, patient age, and serum inflammatory biomarkers (S100A8/A9 and granulysin) might help predict SOC progression in patients with SJS/TEN who need prompt and aggressive ocular management to prevent severe ocular sequelae.

Published
2021

4. Impact of Myopia on Corneal Biomechanics in Glaucoma and Nonglaucoma Patients

Author

Shan C. Lin, Sunee Chansangpetch, Rawiphan Panpruk, Anita Manassakorn, Cameron Hurst, Visanee Tantisevi, and Prin Rojanapongpun

Subjects
Male, Retinal Ganglion Cells, medicine.medical_specialty, Open angle glaucoma, genetic structures, Scheimpflug principle, Gonioscopy, Visual Acuity, Glaucoma, Cornea, 03 medical and health sciences, Tonometry, Ocular, 0302 clinical medicine, Nerve Fibers, Ophthalmology, Myopia, Medicine, Humans, Corneal deformation, Intraocular Pressure, medicine.diagnostic_test, business.industry, Biomechanics, Ocular rigidity, Middle Aged, medicine.disease, eye diseases, Elasticity, Biomechanical Phenomena, medicine.anatomical_structure, Cross-Sectional Studies, 030221 ophthalmology & optometry, Female, sense organs, Visual Fields, business, corneal biomechanics, 030217 neurology & neurosurgery, Glaucoma, Open-Angle, Tomography, Optical Coherence
Abstract

Purpose We evaluated the impact of myopia on corneal biomechanical properties in primary open-angle glaucoma (POAG) and nonglaucoma patients, and the effect of modification of glaucoma on myopic eyes. Methods This cross-sectional study included 66 POAG eyes (33 myopia, 33 nonmyopia) and 66 normal eyes (33 myopia, 33 nonmyopia). Seven corneal biomechanical parameters were measured by ultra-high-speed Scheimpflug imaging, including corneal deformation amplitude (CDA), inward/outward corneal applanation length (ICA, OCA), inward/outward corneal velocity (ICV, OCV), radius, and peak distance (PD). Results Mean age (SD) of the 65 male (49%) and 67 female (51%) patients was 59 (9.82) years. Myopia was associated with significantly higher CDA (adjusted effect = 0.104, P = 0.001) and lower OCV (adjusted effect = -0.105, P < 0.001) in the POAG group. Within the nonglaucoma group, myopic eyes had a significantly lower OCV (adjusted effect = -0.086, P < 0.001) and higher CDA (adjusted effect = 0.079, P = 0.001). All parameters except PD suggested that glaucoma modified the effect of myopia on corneal biomechanics. Percentage differences in the adjusted myopic effect between POAG and nonglaucoma patients was 31.65, 27.27, 31.65, 50.00, 22.09, and 60.49 for CDA, ICA, OCA, ICV, OCV, and radius, respectively. Conclusions Myopia had a significant impact on corneal biomechanical properties in the POAG and nonglaucoma groups. The differences in corneal biomechanical parameters suggest that myopia is correlated with significantly lower ocular rigidity. POAG may enhance the effects of myopia on most of these parameters.

Published
2017

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