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Background: Over a decade, tissues dissected adjacent to primary tumors have been considered "normal " or healthy samples (NATs). However, NATs have recently been discovered to be distinct from both tumorous and normal tissues. The ability to predict the survival rate of cancer patients using NATs can open a new door to selecting optimal treatments for cancer and discovering biomarkers. Methods: This paper introduces an artificial intelligence (AI) approach that uses NATs for predicting the 5-year survival of pre-operative radiotherapy patients with rectal cancer. The new approach combines pre-trained deep learning, nonlinear dynamics, and long short-term memory to classify immunohistochemical images of RhoB protein expression on NATs. Results: Ten-fold cross-validation results show 88% accuracy of prediction obtained from the new approach, which is also higher than those provided from baseline methods. Conclusion: Preliminary results not only add objective evidence to recent findings of NATs molecular characteristics using state-of-the-art AI methods, but also contribute to the discovery of RhoB expression on NATs in rectal-cancer patients. Clinical impact: The ability to predict the survival rate of cancer patients is extremely important for clinical decision-making. The proposed AI tool is promising for assisting oncologists in their treatments of rectal cancer patients.

Quick, early, and precise detection is important for diagnosis to control the spread of COVID-19 infection. Artificial Intelligence (AI) technology could certainly be used as a modulating tool to ease the detection, and help with the preventive steps further. Convolutional neural networks (CNNs) have achieved state-of-the-art performance in many visual recognition tasks. Nevertheless, most of these state-of-the-art networks highly rely on the availability of a high amount of labeled data, being an essential step in supervised machine learning tasks. Conventionally, this manual, mundane, and time-consuming process of annotating images is done by humans. Learning to localize or detect COVID-19 infection masks in our specific case study typically requires the collection of CT scan data that has been labeled with bounding boxes or similar annotations, which generally is limited. A technique that could perform such learning with much less annotations, and transfer the learned proposals that are algorithm-driven to generate more synthetic annotated samples would be helpful & quite valuable. We present such a technique inspired by weakly trained mask region based convolutional neural networks (R-CNN) architecture for localization, in which the number of images with their pixel-level masks can be a small proportion of the total dataset, and then further improvise CNNs by inversely generating dense annotations on-the-go using an algorithmic-based computational approach. We focus on alleviating the bottleneck associated with deep learning models needing annotated data for training in an intuitive reverse engineering fashion through this work. Our proposed solution can certainly provide the prospect of automated labeling on-the-fly, thereby reducing much of the manual work. As a result, one can quickly train a precise COVID-19 infection detector with the leverage of autonomous frame-by-frame machine generated annotations. The model achieved mean precision accuracy (%) of 0

Cybercriminals use domain generation algorithms (DGAs) to prevent their servers from being potentially blacklisted or shut down. Existing reverse engineering techniques for DGA detection is labor intensive, extremely time-consuming, prone to human errors, and have significant limitations. Hence, an automated real-time technique with a high detection rate is warranted in such applications. In this article, we present a novel technique to detect randomly generated domain names and domain name system (DNS) homograph attacks without the need for any reverse engineering or using nonexistent domain (NXDomain) inspection using deep learning. We provide an extensive evaluation of our model over four large, real-world, publicly available datasets. We further investigate the robustness of our model against three different adversarial attacks: DeepDGA, CharBot, and MaskDGA. Our evaluation demonstrates that our method is effectively able to identify DNS homograph attacks and DGAs and also is resilient to common evading cyberattacks. Promising results show that our approach provides a more effective detection rate with an accuracy of 0.99. Additionally, the performance of our model is compared against the most popular deep learning architectures. Our findings highlight the essential need for more robust detection models to counter adversarial learning.

Aim: The process of biomarker discovery is being accelerated with the application of artificial intelligence (AI), including machine learning. Biomarkers of diseases are useful because they are indicators of pathogenesis or measures of responses to therapeutic treatments, and therefore, play a key role in new drug development. Proteins are among the candidates for biomarkers of rectal cancer, which need to be explored using state-of-the-art AI to be utilized for prediction, prognosis, and therapeutic treatment. This paper aims to investigate the predictive power of Ras homolog family member B (RhoB) protein in rectal cancer. Methods: This study introduces the integration of pretrained convolutional neural networks and support vector machines (SVMs) for classifying biopsy samples of immunohistochemical expression of protein RhoB in rectal-cancer patients to validate its biologic measure in biopsy. Features of the immunohistochemical expression images were extracted by the pretrained networks and used for binary classification by the SVMs into two groups of less and more than 5-year survival rates. Results: The fusion of neural search architecture network (NASNet)-Large for deep-layer feature extraction and classifier using SVMs provided the best average classification performance with a total accuracy = 85%, prediction of survival rate of more than 5 years = 90%, and prediction of survival rate of less than 5 years = 75%. Conclusions: The finding obtained from the use of AI reported in this study suggest that RhoB expression on rectal-cancer biopsy can be potentially used as a biomarker for predicting survival outcomes in rectal-cancer patients, which can be informative for clinical decision making if the patient would be recommended for preoperative therapy.