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5. COVID-19 Related Predisposition to Diabetic Ketoacidosis

Author

Santharaman, Aadhithyaraman, primary, Raj, Kavin, additional, Sankaramangalam, Kesavan, additional, Dewan, Sandesh, additional, Sapkota, Saroj, additional, Chandna, Sanya, additional, Shah, Monarch, additional, Singh, Dhruv, additional, Bassi, Mehak, additional, Luo, Hongxiu, additional, and Redel, Henry, additional

Published
2023
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12. Population Risk Factors for Severe Disease and Mortality in COVID-19 in the United States during the Pre-Vaccine Era: A Retrospective Cohort Study of National Inpatient Sample

Author

Raj, Kavin, primary, Yeruva, Karthik, additional, Jyotheeswara Pillai, Keerthana, additional, Kumar, Preetham, additional, Agrawal, Ankit, additional, Chandna, Sanya, additional, Khuttan, Akhilesh, additional, Tripathi, Shalini, additional, Akella, Ramya, additional, Gudi, Thulasi Ram, additional, Watts, Abi, additional, Toquica Gahona, Christian C, additional, Bhagat, Umesh, additional, Aedma, Surya Kiran, additional, Jalal, Ayesha Tamkinat, additional, Ganti, Shyam, additional, Varadarajan, Padmini, additional, and Pai, Ramdas G, additional

Published
2022
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13. Independent Predictors of Mortality in COVID-19 Myocardial Injury: The Role of Troponin Levels, GRACE Score, SOFA Score, and TIMI Score

Author

Raj, Kavin, primary, Mahajan, Pranav, additional, Watts, Abi, additional, Aedma, Surya, additional, Jose, Jemin Aby, additional, Jyotheeswara Pillai, Keerthana, additional, Rizkalla, Adam, additional, Sharma, Suyansh, additional, Upadhyay, Riddhi, additional, Dhobale, Swati, additional, Bin Farooq, Talha, additional, Khanam, Rukhsaar, additional, Patel, Keval V, additional, and Martin, Randolph, additional

Published
2022
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20. Abstract 9549: Role of Troponin Levels, Grace Score, and Timi Score in Predicting Mortality in Covid-19 Related Myocardial Injury

Author

raj, Kavin, primary, mahajan, pranav, additional, Shah, Monarch, additional, Jose, Jemin, additional, Watts, Abi, additional, Kiran Aedma, Surya, additional, Dhobale, Swati, additional, Upadhyay, Riddhi, additional, Rizkalla, Adam, additional, Sharma, Suyansh, additional, khanam, rukhsaar, additional, Bin Farooq, Talha, additional, Keval, Patel, additional, Martin, Randolph, additional, and Manohar, Hasitha, additional

Published
2021
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27. Increased risk of pulmonary embolism and deep vein thrombosis with COVID-19 pneumonia in comparison to influenza pneumonia: insights from the National Inpatient Sample database.

Author

Raj K, Majeed H, Chandna S, Chitkara A, Sheikh AB, Kumar A, Gangu K, Pillai KJ, Agrawal A, Sadashiv SK, and Kalra A

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily a respiratory virus causing coronavirus disease 2019 (COVID-19) pneumonia, induces a hypercoagulable state. Previous studies comparing the prevalence of venous thromboembolism (VTE) in patients with COVID-19 pneumonia and those with influenza pneumonia revealed a higher risk of pulmonary embolism (PE) and deep vein thrombosis (DVT) associated with COVID-19 pneumonia. However, these studies have not adequately accounted for the severity and acuity of the presenting viral pneumonia., Methods: In this retrospective study, we rigorously adjusted for critical illness using a nationally representative dataset to investigate whether COVID-19 pneumonia is independently linked to a higher risk of PE and DVT., Results: After comprehensive multivariate adjustment, our findings demonstrated that patients with COVID-19 pneumonia maintained significantly higher odds of developing acute inpatient PE [adjusted odds ratio (aOR): 2.48; 95% confidence interval (CI): 2.16-2.86; P<0.01] and DVT (aOR: 1.66; 95% CI: 1.41-1.96; P<0.01) during the early pandemic compared to patients with influenza pneumonia. Furthermore, we identified congenital heart disease and malnutrition as novel risk factors for acute PE in COVID-19 patients., Conclusions: Our study suggests that the higher prevalence of acute inpatient PE over DVT in patients with COVID-19 pneumonia may support a "thrombus in situ " mechanism of SARS-CoV-2-mediated pulmonary thrombosis. Consequently, clinicians should maintain a high index of suspicion for PE, even in the absence of DVT, among patients with COVID-19 pneumonia and should follow evidence-based guidelines for diagnosis and management., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-23-1674/coif). The series “Thoracic Diseases and Big Data” was commissioned by the editorial office without any funding or sponsorship. The authors have no other conflicts of interest to declare., (2024 AME Publishing Company. All rights reserved.)

Published
2024
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28. Prevalence and patient risk factors for pneumothorax in COVID-19 and in influenza pneumonia: a nationwide comparative analysis.

Author

Chandna S, Raj K, Agrawal A, Nanda S, Jyotheeswara Pillai K, Bhagat U, Bajaj S, Raoof S, and Mehta AC

Abstract

Background: Pneumothorax is a rare but deadly complication in patients who require mechanical ventilation. As with any condition associated with acute respiratory distress syndrome (ARDS), coronavirus disease 2019 (COVID-19) is known to be associated with pneumothorax. However, in the literature, comparative data on the risk factors for pneumothorax in COVID-19 and other diseases like influenza are limited. The aim of this study is to determine the prevalence and risk factors for pneumothorax in hospitalized COVID-19 patients and compare them with influenza pneumonia patients., Methods: This study is a retrospective analysis of the National Inpatient Sample (NIS) 2020 database cohort. Univariate and multivariate logistic regression were used to identify the prevalence and risk factors for pneumothorax in COVID-19 patients and compared with the risk of pneumothorax in influenza patients., Results: The NIS 2020 database includes 1,608,980 hospitalizations of COVID-19 patients, of which 22,545 [95% confidence interval (CI): 21,491-23,598] (1.4%) developed pneumothorax. On multivariate analysis, factors associated with pneumothorax in COVID-19 included patient age of 41-64 years; male sex; Hispanics, Native Americans, and other races; hospitals with large-bed size; privately owned hospitals; urban teaching hospitals; hospitals in the southern United States (US); stroke; malnutrition; chronic obstructive pulmonary disease (COPD); bronchiectasis; pulmonary fibrosis; liver disease; non-invasive and invasive ventilation; and extracorporeal membrane oxygenation (ECMO). Of 184,980 influenza patients, 1,630 (95% CI: 1,448-1,811) (0.88%) developed pneumothorax. The prevalence of pneumothorax was higher (1.4%) in COVID-19 patients compared to patients with influenza pneumonia (0.88%)., Conclusions: COVID-19 patients who develop pneumothorax have a poor prognosis. Several risk factors for the development of pneumothorax were identified. Patients with these risk factors should be prioritized in applying evidence-based guidelines to prevent pneumothorax., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-23-1454/coif). The authors have no conflicts of interest to declare., (2024 Journal of Thoracic Disease. All rights reserved.)

Published
2024
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