The efficiency of hybrid electric vehicles may be substantially increased if the energy of exhaust gases, which do not complete the expansion inside the cylinder of the internal combustion engine, is efficiently recovered using a properly designed turbo-generator and employed for vehicle propulsion. Previous studies, carried out by the same authors of this work, showed a potential hybrid vehicle fuel efficiency increment up to 15% employing a 20 kW turbine on a 100 HP-rated power thermal unit. The innovative thermal unit proposed here is composed of a supercharged engine endowed with a properly designed turbo-generator, which comprises two fundamental elements: an exhaust gas turbine expressly designed and optimized for the application, and a suitable electric generator necessary to convert the recovered energy into electric energy, which can be stored in the on-board energy storage system of the vehicle. In this two-part work, the realistic efficiency of the innovative thermal unit for hybrid vehicles is evaluated and compared to a traditional turbocharged engine. In Part 1, the authors presented a model for the prediction of the efficiency of a dedicated radial turbine, based on a simple but effective mean-line approach; the same paper also reports a design algorithm, which, thanks to some assumptions and approximations, allows fast determination of the right turbine geometry for a given design operating condition. It is worth pointing out that, being optimized for quasi-steady power production, the exhaust gas turbine here considered is quite different from the ones commonly employed for turbocharging applications; for this reason, and in consideration of the required power size, such a turbine is not available on the market, nor has its development been previously carried out in the scientific literature. In this paper, Part 2, a radial turbine geometry is defined for the thermal unit previously calculated, employing the design algorithm described in Part 1; the realistic energetic advantages that could be achieved by the implementation of the turbo-generator on a hybrid propulsion system are evaluated through the performance prediction model under different operating conditions of the thermal unit. As an overall result, it was estimated that, compared to a reference traditional turbocharged engine, the turbo-compound system could gain vehicle efficiency improvement between 3.1% and 17.9%, according to the output power delivered, with an average efficiency increment of 10.9% evaluated on the whole operating range. [ABSTRACT FROM AUTHOR]