14 results on '"Raaijmakers, A.J.E."'
Search Results
2. RF safety assessment in ultra-high field MRI: New approaches to reduce local SAR estimation errors
- Author
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Berg, C.A.T. van den, Luijten, P.R., Raaijmakers, A.J.E., Sbrizzi, A., Meliadò, Ettore Flavio, Berg, C.A.T. van den, Luijten, P.R., Raaijmakers, A.J.E., Sbrizzi, A., and Meliadò, Ettore Flavio
- Published
- 2023
3. Potential Reduction of Peripheral Local SAR for a Birdcage Body Coil at 3 Tesla Using a Magnetic Shield
- Author
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van Leeuwen, C.C., primary, Steensma, B.R., additional, Glybovski, S.B., additional, Lunenburg, M.F.J., additional, Simovski, C., additional, Klomp, D.W.J., additional, van den Berg, C.A.T., additional, and Raaijmakers, A.J.E., additional
- Published
- 2021
- Full Text
- View/download PDF
4. Introduction of Ultra-High-Field MR Imaging in Infants: Preparations and Feasibility
- Author
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Annink, K.V., primary, van der Aa, N.E., additional, Dudink, J., additional, Alderliesten, T., additional, Groenendaal, F., additional, Lequin, M., additional, Jansen, F.E., additional, Rhebergen, K.S., additional, Luijten, P., additional, Hendrikse, J., additional, Hoogduin, H.J.M., additional, Huijing, E.R., additional, Versteeg, E., additional, Visser, F., additional, Raaijmakers, A.J.E., additional, Wiegers, E.C., additional, Klomp, D.W.J., additional, Wijnen, J.P., additional, and Benders, M.J.N.L., additional
- Published
- 2020
- Full Text
- View/download PDF
5. MRI safety of implants: transfer function determination from MR images
- Author
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Luijten, P.R., Berg, C.A.T. van den, Raaijmakers, A.J.E., Tokaya, Janot Philippe, Luijten, P.R., Berg, C.A.T. van den, Raaijmakers, A.J.E., and Tokaya, Janot Philippe
- Published
- 2020
6. A deep learning method for image-based subject-specific local SAR assessment
- Author
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Meliadò, E.F., Raaijmakers, A.J.E., Sbrizzi, A., Steensma, B.R., Maspero, M., Savenije, M.H.F., Luijten, P.R., van den Berg, C.A.T., Meliadò, E.F., Raaijmakers, A.J.E., Sbrizzi, A., Steensma, B.R., Maspero, M., Savenije, M.H.F., Luijten, P.R., and van den Berg, C.A.T.
- Abstract
Purpose: Local specific absorption rate (SAR) cannot be measured and is usually evaluated by offline numerical simulations using generic body models that of course will differ from the patient's anatomy. An additional safety margin is needed to include this intersubject variability. In this work, we present a deep learning–based method for image-based subject-specific local SAR assessment. We propose to train a convolutional neural network to learn a “surrogate SAR model” to map the relation between subject-specific (Formula presented.) maps and the corresponding local SAR. Method: Our database of 23 subject-specific models with an 8–transmit channel body array for prostate imaging at 7 T was used to build 5750 training samples. These synthetic complex (Formula presented.) maps and local SAR distributions were used to train a conditional generative adversarial network. Extra penalization for local SAR underestimation errors was included in the loss function. In silico and in vivo validation were performed. Results: In silico cross-validation shows a good qualitative and quantitative match between predicted and ground-truth local SAR distributions. The peak local SAR estimation error distribution shows a mean overestimation error of 15% with 13% probability of underestimation. The higher accuracy of the proposed method allows the use of less conservative safety factors compared with standard procedures. In vivo validation shows that the method is applicable with realistic measurement data with impressively good qualitative and quantitative agreement to simulations. Conclusion: The proposed deep learning method allows online image-based subject-specific local SAR assessment. It greatly reduces the uncertainty in current state-of-the-art SAR assessment methods, reducing the time in the examination protocol by almost 25%.
- Published
- 2020
7. Combining a reduced field of excitation with SENSE-based parallel imaging for maximum imaging efficiency
- Author
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Mooiweer, R., Sbrizzi, A., Raaijmakers, A.J.E., van den Berg, C.A.T., Luijten, P.R., Hoogduin, H., and Medical Image Analysis
- Subjects
reduced field of excitation ,voxel exclusion ,parallel imaging ,inner volume imaging - Abstract
PURPOSE: To show that a combination of parallel imaging using sensitivity encoding (SENSE) and inner volume imaging (IVI) combines the known benefits of both techniques. SENSE with a reduced field of excitation (rFOX) is termed rSENSE. THEORY AND METHODS: The noise level in SENSE reconstructions is reduced by removing voxels from the unfolding process that are rendered silent by using rFOX. The silent voxels need to be identified beforehand, this is done by using rFOX in the coil sensitivity maps. In vivo experiments were performed at 7 Tesla using a 32-channel receive coil. RESULTS: Good image quality could be obtained in vivo with rSENSE at acceleration factors that are higher than could be obtained using SENSE or IVI alone. With rSENSE we were also able to accelerate scans using an rFOX that was purposely designed to be imperfect or incompatible at all with IVI. CONCLUSION: rSENSE has been demonstrated in vivo with two-dimensionally selective radiofrequency pulses. Besides allowing additional scan acceleration, it offers a greater robustness and flexibility than IVI. The proposed method can be used with other field strengths, anatomies and other rFOX techniques. Magn Reson Med 78:88-96, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- Published
- 2017
8. An 8-channel Tx/Rx dipole array combined with 16 Rx loops for high-resolution functional cardiac imaging at 7 T
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Steensma, B.R., Voogt, I.J., Leiner, T., Luijten, P.R., Habets, J., Klomp, D.W.J., van den Berg, C.A.T., Raaijmakers, A.J.E., Steensma, B.R., Voogt, I.J., Leiner, T., Luijten, P.R., Habets, J., Klomp, D.W.J., van den Berg, C.A.T., and Raaijmakers, A.J.E.
- Abstract
Objective: To demonstrate imaging performance for cardiac MR imaging at 7 T using a coil array of 8 transmit/receive dipole antennas and 16 receive loops. Materials and methods: An 8-channel dipole array was extended by adding 16 receive-only loops. Average power constraints were determined by electromagnetic simulations. Cine imaging was performed on eight healthy subjects. Geometrical factor (g-factor) maps were calculated to assess acceleration performance. Signal-to-noise ratio (SNR)-scaled images were reconstructed for different combinations of receive channels, to demonstrate the SNR benefits of combining loops and dipoles. Results: The overall image quality of the cardiac functional images was rated a 2.6 on a 4-point scale by two experienced radiologists. Imaging results at different acceleration factors demonstrate that acceleration factors up to 6 could be obtained while keeping the average g-factor below 1.27. SNR maps demonstrate that combining loops and dipoles provides a more than 50% enhancement of the SNR in the heart, compared to a situation where only loops or dipoles are used. Conclusion: This work demonstrates the performance of a combined loop/dipole array for cardiac imaging at 7 T. With this array, acceleration factors of 6 are possible without increasing the average g-factor in the heart beyond 1.27. Combining loops and dipoles in receive mode enhances the SNR compared to receiving with loops or dipoles only.
- Published
- 2018
9. High-resolution T2-weighted cervical cancer imaging: a feasibility study on ultra-high-field 7.0-T MRI with an endorectal monopole antenna
- Author
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Hoogendam, J.P., Kalleveen, I.M.L., Arteaga de Castro, C.S., Raaijmakers, A.J.E., Verheijen, R.H.M., van den Bosch, M.A.A.J., Klomp, D.W.J., Zweemer, R.P., Veldhuis, W.B., Hoogendam, J.P., Kalleveen, I.M.L., Arteaga de Castro, C.S., Raaijmakers, A.J.E., Verheijen, R.H.M., van den Bosch, M.A.A.J., Klomp, D.W.J., Zweemer, R.P., and Veldhuis, W.B.
- Abstract
OBJECTIVES: We studied the feasibility of high-resolution T2-weighted cervical cancer imaging on an ultra-high-field 7.0-T magnetic resonance imaging (MRI) system using an endorectal antenna of 4.7-mm thickness.METHODS: A feasibility study on 20 stage IB1-IIB cervical cancer patients was conducted. All underwent pre-treatment 1.5-T MRI. At 7.0-T MRI, an external transmit/receive array with seven dipole antennae and a single endorectal monopole receive antenna were used. Discomfort levels were assessed. Following individualised phase-based B1+ shimming, T2-weighted turbo spin echo sequences were completed.RESULTS: Patients had stage IB1 (n = 9), IB2 (n = 4), IIA1 (n = 1) or IIB (n = 6) cervical cancer. Discomfort (ten-point scale) was minimal at placement and removal of the endorectal antenna with a median score of 1 (range, 0-5) and 0 (range, 0-2) respectively. Its use did not result in adverse events or pre-term session discontinuation. To demonstrate feasibility, T2-weighted acquisitions from 7.0-T MRI are presented in comparison to 1.5-T MRI. Artefacts on 7.0-T MRI were due to motion, locally destructive B1 interference, excessive B1 under the external antennae and SENSE reconstruction.CONCLUSIONS: High-resolution T2-weighted 7.0-T MRI of stage IB1-IIB cervical cancer is feasible. The addition of an endorectal antenna is well tolerated by patients.KEY POINTS: • High resolution T 2 -weighted 7.0-T MRI of the inner female pelvis is challenging • We demonstrate a feasible approach for T 2 -weighted 7.0-T MRI of cervical cancer • An endorectal monopole receive antenna is well tolerated by participants • The endorectal antenna did not lead to adverse events or session discontinuation.
- Published
- 2017
10. 7 T renal MRI: challenges and promises
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de Boer, A., Hoogduin, J.M., Blankestijn, P.J., Li, X., Luijten, P.R., Metzger, G.J., Raaijmakers, A.J.E., Umutlu, L., Visser, F., Leiner, T., de Boer, A., Hoogduin, J.M., Blankestijn, P.J., Li, X., Luijten, P.R., Metzger, G.J., Raaijmakers, A.J.E., Umutlu, L., Visser, F., and Leiner, T.
- Abstract
The progression to 7 Tesla (7 T) magnetic resonance imaging (MRI) yields promises of substantial increase in signal-to-noise (SNR) ratio. This increase can be traded off to increase image spatial resolution or to decrease acquisition time. However, renal 7 T MRI remains challenging due to inhomogeneity of the radiofrequency field and due to specific absorption rate (SAR) constraints. A number of studies has been published in the field of renal 7 T imaging. While the focus initially was on anatomic imaging and renal MR angiography, later studies have explored renal functional imaging. Although anatomic imaging remains somewhat limited by inhomogeneous excitation and SAR constraints, functional imaging results are promising. The increased SNR at 7 T has been particularly advantageous for blood oxygen level-dependent and arterial spin labelling MRI, as well as sodium MR imaging, thanks to changes in field-strength-dependent magnetic properties. Here, we provide an overview of the currently available literature on renal 7 T MRI. In addition, we provide a brief overview of challenges and opportunities in renal 7 T MR imaging.
- Published
- 2016
11. MR-guided radiotherapy: magnetic field dose effects
- Author
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Raaijmakers, A.J.E., Lagendijk, JJW, Raaymakers, Bas W., and University Utrecht
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hormones, hormone substitutes, and hormone antagonists - Abstract
At the UMC Utrecht, together with Elekta Oncology and Philips Research, we are developing a combined system of a 1.5 Tesla MRI scanner and a 6 MV linear accelerator for cancer treatment. In contrast to present online imaging methods, superior soft-tissue contrast will be achieved. The system will enable patient positioning based on the tumour itself. In the design, the patient will be irradiated in the presence of a 1.5 Tesla magnetic field. This will affect the dose distribution, due to the Lorentz force acting on the secondary electrons. These so-called magnetic field dose effects have been investigated using the Monte Carlo code GEANT4. In homogeneous media, the magnetic field causes a reduced build-up distance and a shifted, asymmetric penumbra. At tissue-air boundaries dose increase of 40% is shown, due to electrons returning into the phantom by arc-shaped trajectories. This phenomenon has been called ‘Electron Return Effect’ (ERE). The ERE will take effect at the distal side of the treatment beam and at the proximal side of interior air cavities within the patient. The ERE in the latter case can be compensated by using opposing beams. We validated the simulation results of GEANT4 by comparison to dose measurements at 0, 0.6 and 1.3 Tesla. We demonstrated that both the reduced build-up distance and the ERE are highly dependent on surface orientation. If the treatment beam extends over the edges of a phantom, the so-called lateral ERE causes a dose increase of 50% relative to the central axis dose. We showed that even for oblique incidence opposing beams still have a compensating effect. We also investigated the ERE at the distal side, the lateral ERE, ERE at air cavities and ERE at tissue-lung transitions for magnetic field values of 0.2, 0.75, 1.5 and 3 Tesla. Results show that the ERE is reduced by lower magnetic field strengths, in particular for small irradiation fields, the lateral ERE, small cavities and lung tissue. However, for large irradiation fields (10 cm) and large interior air cavities (3 cm), the ERE reaches considerable levels of exit dose increase for all magnetic field values. For air cavities within the patient near the target, multiple beams, although not necessarily opposing, do have a compensating effect on the ERE dose increase. The remaining dose inhomogeneities can be dealt with by IMRT. We designed an inverse treatment planning approach, to calculate optimized IMRT dose distributions in the presence of a magnetic field. We used this method to calculate optimized IMRT treatment plans for a prostate cancer, a laryngeal cancer and an oropharyngeal cancer at B = 0 and 1.5 Tesla. Results hardly showed any differences between B = 0 and 1.5 T in terms of target coverage and sparing of organs at risk. This thesis shows that radiotherapy treatment in the presence of a magnetic field is feasible.
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- 2008
12. MR-guided radiotherapy: magnetic field dose effects
- Author
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Lagendijk, JJW, Raaymakers, Bas W., Raaijmakers, A.J.E., Lagendijk, JJW, Raaymakers, Bas W., and Raaijmakers, A.J.E.
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- 2008
13. MR-guided radiotherapy: magnetic field dose effects
- Author
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Fysica Radiotherapie Research, Lagendijk, JJW, Raaymakers, Bas, Raaijmakers, A.J.E., Fysica Radiotherapie Research, Lagendijk, JJW, Raaymakers, Bas, and Raaijmakers, A.J.E.
- Published
- 2008
14. MRI safety of implants: transfer function determination from MR images
- Author
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Tokaya, Janot Philippe, Luijten, P.R., Berg, C.A.T. van den, Raaijmakers, A.J.E., University Utrecht, Luijten, Peter R, van den Berg, CAT, and Raaijmakers, AJE
- Subjects
implantaten ,EM simulaties ,RF ,transfer matrix ,veiligheid ,transfer functie ,MRI - Abstract
MRI is often considered to be a risk for patients with medical implants, like pacemakers and deep brain stimulators. The heating around the electrodes of these type of implants that are in contact with human tissue to deliver therapeutic doses is one of the most notorious challenges. Unintendedly, the implants can act as antennas and pick up energy from the radiofrequency field that is necessary to produce MR images and deposit it locally causing focused temperature hot spots. This process is described by the so-called transfer function of an implant. It is challenging to get an accurate estimate of the heating around the electrodes because it depends on many factors. The design of the implant, the anatomy of the patient, the type of RF coil, the relative positions of the implant, the patient and the RF coil all influence the heating. As shown in this thesis MRI can be used to measure the transfer function of an implant and hence get an accurate description of its interaction with the radio frequency field in more realistic scenarios. Nowadays transfer functions can only be measured in phantoms in straight trajectories in dedicated measurements setups. Translating these transfer functions to in-vivo situations introduce currently unknown uncertainties which can be probed using the MRI methods described in this thesis. This provides options for implant manufacturers to describe their products better and has the potential to improve care for an increasing patient population.
- Published
- 2020
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