8 results on '"Puscas Alexandra"'
Search Results
2. The Impact of Hyponatremia in Aortic Valve Surgery Using Histidine–Tryptophan–Ketoglutarate Cardioplegia
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Ghiragosian Claudiu, Baba Dragos-Florin, Harpa Marius, Puscas Alexandra, Balau Radu, Al Hussein Hussam, Ghiragosian-Rusu Simina Elena, Avram Calin, Neagoe Radu Mircea, and Suciu Horatiu
- Subjects
perioperative hyponatremia ,histidine–tryptophan–ketoglutarate cardioplegia ,aortic valve surgery ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Histidine–tryptophan–ketoglutarate (HTK) cardioplegia is one of the most widely used methods of cardioplegia. This solution is hyponatremic compared to blood, and the rapid infusion of a substantial volume of hyponatremic solution will result in a notable reduction in serum natrium (Na) levels. The aim of this study was to analyze changes in serum Na concentration following HTK cardioplegia infusion in aortic valve surgery, and to investigate the association between hyponatremia and postoperative outcomes in patients who underwent aortic valve replacement surgery.
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- 2024
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3. Weekend Effect and Mortality Outcomes in Aortic Dissection: A Prospective Analysis
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Banceu Cosmin Marian, Harpa Marius, Brinzaniuc Klara, Neagu Nicolae, Szabo Dan Alexandru, Banceu Diana Mariana, Al Hussein Hussam, Cristutiu Daiana, Puscas Alexandra, Stan Alexandru, Oprean Marvin, Popentiu Adrian, Halic Marius Neamtu, and Suciu Horatiu
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aortic dissection ,weekend effect ,risk factors ,mortality outcome ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Aortic dissection (AD) is a critical heart condition with potentially severe outcomes. Our study aimed to investigate the existence of a “weekend effect” in AD by examining the correlation between patient outcomes and whether their treatment occurred on weekdays versus weekends.
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- 2024
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4. Bioengineered Small-Diameter Vascular Xenografts as an Alternative to Autologous Vascular Grafting for Emergency Revascularization – a Preliminary Study
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Harpa Marius Mihai, Oltean Sânziana Flămând, Puscas Alexandra Iulia, Truta Raluca, Anitei David Emanuel, Ghiragosian Claudiu, Banceu Cosmin, Movileanu Ionela, Cotoi Ovidiu Simion, Niculescu Raluca, Suciu Horatiu, Simionescu Dan, and Hussein Hussam Al
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vascular grafting ,emergency revascularization ,bioengineering ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Autologous vascular arterial or venous graft are not available in 10-40% of patients, due to vascular pathologies, and the utility of decellularized biological scaffolds would be a solution for those cases. The purpose of this research was to obtain a functional acellular xenograft, prior to in-vivo testing as a vascular graft in an experimental animal.
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- 2023
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5. The Gender Gap in Aortic Dissection: A Prospective Analysis of Risk and Outcomes
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Banceu, Cosmin, primary, Harpa, Marius, additional, Brinzaniuc, Klara, additional, Tilea, Ioan, additional, Varga, Andreea, additional, Gliga, Mirela Liana, additional, Voidazan, Septimiu, additional, Neagu, Nicolae, additional, Szabo, Dan Alexandru, additional, Banceu, Diana, additional, Cristutiu, Daiana, additional, Balmos, Ionut Alexandru, additional, Puscas, Alexandra, additional, Oprean, Marvin, additional, and Suciu, Horatiu, additional
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- 2023
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6. Evaluation of Perioperative Beta-Blockers and Factors Associated with Postoperative Atrial Fibrillation in Cardiac Surgery: A Single Center Experience.
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Puscas, Alexandra, Harpa, Marius M., Brinzaniuc, Klara, Al-Hussein, Hussam, Al-Hussein, Hamida, Banceu, Cosmin, Opris, Carmen, Ghiragosian, Claudiu, Flamind, Sanziana, Balan, Robert, Voidazan, Septimiu, and Suciu, Horatiu
- Abstract
Background: Postoperative atrial fibrillation (AF) has a complex etiology, and beta-blockers are commonly recommended for its pharmacological prevention. This study aims to assess the impact of beta-blocker therapy on postoperative AF occurrence in patients undergoing aortic valve replacement, mitral valve replacement, surgical revascularization of the myocardium, or a combination of these procedures. Methods: The study encompassed 472 patients who received aortic valve replacement, mitral valve replacement, surgical revascularization, or their combination. We evaluated the efficacy of preoperative and one-month postoperative beta-blocker administration in preventing postoperative AF, and the associated risk factors involved in the development of postoperative AF. Results: Of the total patient population, 36% experienced postoperative AF. Our study demonstrated a significant reduction in postoperative AF incidence among patients receiving beta-blocker treatment (all p-values < 0.05). Additionally, one-month post-surgery, beta-blocker treatment exerted a protective effect by maintaining the sinus rhythm (p = 0.0001). Regarding the risk factors involved in the development of postoperative AF, both age and left atrium (LA) sizeassessed pre-and postoperatively--were positively correlated with the occurrence of postoperative AF (p = 0.006). No relationship was found between leukocyte counts and AF incidence. Notably, C-reactive protein (CRP) levels were significantly elevated on the fifth postoperative day in patients with AF (p < 0.007). The duration of ischemia was significantly longer in patients with AF (p = 0.009). Conclusions: This study establishes the efficacy of perioperative beta-blocker treatment in mitigating postoperative AF. One month post-surgery, most patients under beta-blocker therapy maintained sinus rhythm, suggesting a potential long-term protective effect of beta-blockers against late-onset AF. [ABSTRACT FROM AUTHOR]
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- 2023
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7. A multi-actor, participatory approach to identify policy and technical barriers to better farming practices that protect our drinking water sources
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Campling, Paul, Joris, Ingeborg, Calliera, Maura, Capri, Ettore, Marchis, Alexandru, Kuczyńska, Anna, Vereijken, Tom, Majewska, Zuzanna, Belmans, Els, Borremans, Lieve, Dupon, Elien, Pauwelyn, Ellen, Mellander, Per Erik, Fennell, Christopher, Fenton, Owen, Burgess, Edward, Puscas, Alexandra, Gil, Elena Isla, de Alda, Miren Lopez, Tudel, Gemma Francès, Andersen, Erling, Højber, Anker Lajer, Nowakowska, Marzena, Suciu, Nicoleta, Campling, Paul, Joris, Ingeborg, Calliera, Maura, Capri, Ettore, Marchis, Alexandru, Kuczyńska, Anna, Vereijken, Tom, Majewska, Zuzanna, Belmans, Els, Borremans, Lieve, Dupon, Elien, Pauwelyn, Ellen, Mellander, Per Erik, Fennell, Christopher, Fenton, Owen, Burgess, Edward, Puscas, Alexandra, Gil, Elena Isla, de Alda, Miren Lopez, Tudel, Gemma Francès, Andersen, Erling, Højber, Anker Lajer, Nowakowska, Marzena, and Suciu, Nicoleta
- Abstract
Despite an improvement of water quality across Europe there are many pollution hotspots for both nitrates and PPPs, mainly due to agricultural activities. The BMPs and MMs to reduce pollution from agriculture are well known, and there are policy instruments in place to ensure drinking water standards, but the current approach has not been efficient enough. Within the H2020 Water Protect project the premise was that there is a need for a multi-actor, participatory approach to tackle the issue from a new angle, and to assess why the uptake of known BMPs and MMs was not better among farmers. Seven “Action Labs” were selected that represent major physical, socio-economical, cultural and farming settings across Europe. A methodology of multi-actor engagement was chosen but with different approaches due to the local context. Initially the level of farmers' awareness about water quality issues was matched to the observed uptake rates of BMPs and MMs. In a second survey barriers hindering the uptake of measures were identified. The first survey revealed a low general awareness on the potential pollution to drinking water sources. Despite this, between 24% to 88% of the surveyed farmers per Action Lab were already voluntarily adopting one quarter of the selected BMPs and MMs. The second survey demonstrated the need to address organisational, legislative, sociological and technical barriers. The lack of coordination between different institutional bodies promoting measures and the financial incentives needed to invest and operate these often-costly measures need to be considered. The multi-actor, participatory approach with its improved awareness and collaboration made it possible to identify the crucial factors for improvement - to build a social acceptance among all actors and communicate the issues and solutions from the start.
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- 2021
8. Histidine-Tryptophan-Ketoglutarate Cardioplegia Yields Different Results in Aortic Valve Surgery Depending on Patient Gender: A Pilot Study.
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Ghiragosian C, Harpa M, Puscas A, Balau R, Al-Hussein H, Ghiragosian-Rusu SE, Avram C, Baba DF, Neagoe R, and Suciu H
- Abstract
Background: Histidine-tryptophan-ketoglutarate (HTK) cardioplegia induces cardiac arrest through membrane hyperpolarization. Aortic valve pathology leads to pathophysiological changes in left ventricular vascularization that may prevent adequate cardioplegic distribution. The objective of the study was to ascertain whether the use of Bretschneider cardioplegia in aortic valve surgery yields different outcomes for male and female patients., Methodology: Our study compares the perioperative data of 300 adult patients who underwent aortic valve replacement between June 2023 and June 2024 at the Emergency Cardiac Disease and Transplant Institute, Tîrgu Mures, Romania. Concomitant procedures, age under 18 years, retrograde or combined cardioplegia, and emergency surgery were excluded. The main outcome was operative mortality, and secondary outcomes were postoperative complications and paraclinical data such as ejection fraction and cardiac enzymes., Results: Male patients comprised 190 (62%) of the sample. The most common age group was 61-70 years in both groups. The mortality rate was 6 (5.4%) for women compared to 9 (4.7%) for men. Preoperative left ventricular ejection fraction was the primary covariate determining 30-day postoperative mortality. Left ventricular ejection fraction decreased by 2.2% in men and 1.1% in women 30 days after surgery., Conclusions: The myocardial adaptation to aortic valve pathology exhibits gender-specific differences. However, the utilization of HTK cardioplegia obviates this disparity., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. The Ethics Committee of Emergency Institute for Cardiovascular Disease and Transplantation, Tîrgu Mures issued approval 3240, 15.04.2024. The study was conducted in accordance with the Declaration of Helsinki. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Ghiragosian et al.)
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- 2024
- Full Text
- View/download PDF
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