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6 results on '"Pricolo, G."'

1. Clinical and diagnostic findings in COVID-19 patients: an original research from SG Moscati Hospital in Taranto Italy

Author

Balzanelli, M., Distratis, P., Catucci, O., Amatulli, F., Cefalo, A., Lazzaro, R., Aityan, K. S., Dalagni, G., Nico, A., Michele, A., Mazza, E., Tampoia, M., D’errico, P., Pricolo, G., Antonella Prudenzano, D’ettorre, E., Di Stasi, C., Morrone, L. F. P., Nguyen, K. C. D., Pham, H. V., Inchingolo, F., Tomassone, D., and Gargiulo Isacco, C.

Subjects
Hospitalization, Male, Intensive Care Units, Italy, COVID-19, Humans, Female, Pandemics, Hospitals
Abstract

The coronavirus disease 2019 (COVID-19) pandemic is a worldwide medical challenge due to the scarcity of proper information and remedial resources. The ability to efficiently avoid a further SARS-CoV-2 pandemic will, therefore, depend on understanding several factors which include host immunity, virus behavior, prevention measures, and new therapies. This is a multi-phase observatory study conducted in the SG Moscati Hospital of Taranto in Italy that was converted into COVID-19 Special Care Unit for SARS-Co-V2 risk management. Patients were admitted to the 118 Emergency Pre-Hospital and Emergency Department based on two diagnostic criteria, the nasopharyngeal swab assessed by reverse-transcriptase-polymerase-chain-reaction (RT-PCR) and CT-scan image characterized by ground glass opacity. Patients were divided into four groups, positive-positive (ER-PP), negative-positive (ER-NP), negative-negative (ER-NN) and a group admitted to the ICU (ER-IC). A further control group was added when the T and B lymphocyte subsets were analyzed. Data included gender, age, vital signs, arterial blood gas analysis (ABG), extensive laboratory results with microbiology and bronchoalveolar lavage fluid (BALF) which were analyzed and compared. Fundamental differences were reported among the groups. Males were significantly higher in PP, ICU, and NP groups, from 2 to 4-fold higher than females, while in the NN group, the number of females was mildly higher than males; the PP patients showed a marked alkalotic, hypoxic, hypocapnia ABG profile with hyperventilation at the time of admission; finally, the laboratory and microbiology results showed lymphopenia, fibrinogen, ESR, CRP, and eGFR were markedly anomalous. The total number of CD4+ and CD8+ T cells was dramatically reduced in COVID-19 patients with levels lower than the normal range delimited by 400/μL and 800/μL, respectively, and were negatively correlated with blood inflammatory responses.

Published
2021

3. Multicentre phase III trial on fludarabine, cytarabine (Ara-C), and idarubicin versus idarubicin, Ara-C and etoposide for induction treatment of younger, newly diagnosed acute myeloid leukaemia patients

Author

Monica Bocchia, Angela Michielutti, Luigi Gugliotta, Donatella Raspadori, Maurizio Castelli, Renato Fanin, Paolo Avanzini, Domenico Russo, Alessandro Bonini, Giancarla Pricolo, Alfonso Zaccaria, M Malagola, Eliana Zuffa, Nicoletta Testoni, Francesco Lauria, Antonio De Vivo, Patrizio Mazza, Pier Paolo Piccaluga, Michele Baccarani, Emanuela Ottaviani, Anna Candoni, Mauro Fiacchini, Daniela Damiani, Giuseppe Visani, Michela Rondoni, Giovanni Martinelli, Russo D, Malagola M, Vivo A, Fiacchini M, Martinelli G, Piccaluga PP, Damiani D, Candoni A, Michielutti A, Castelli M, Testoni N, Ottaviani E, Rondoni M, Pricolo G, Mazza P, Zuffa E, Zaccaria A, Raspadori D, Bocchia M, Lauria F, Bonini A, Avanzini P, Gugliotta L, Visani G, Fanin R, and Baccarani M

Subjects
Adult, Male, medicine.medical_specialty, Transplantation Conditioning, Adolescent, FLAI, Acute myeloid leukaemia, Fludarabine, Multidrug resistance, Therapy, Transplantation, Autologous, Gastroenterology, Leukocyte Count, Autologous stem-cell transplantation, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Mucositis, medicine, Humans, Idarubicin, Prospective Studies, Etoposide, Mitoxantrone, business.industry, Remission Induction, ICE, Cytarabine, Hematology, Middle Aged, medicine.disease, Surgery, Transplantation, Treatment Outcome, Leukemia, Myeloid, Karyotyping, Acute Disease, Female, business, Vidarabine, Stem Cell Transplantation, ACUTE MYELOID LEUKAEMIA, medicine.drug
Abstract

Summary Fludarabine plus cytarabine (Ara-C) and idarubicin (FLAI) is an effective and well-tolerated induction regimen for the treatment of acute myeloid leukaemia (AML). This phase III trial compared the efficacy and toxicity of FLAI versus idarubicin plus Ara-C and etoposide (ICE) in 112 newly diagnosed AML patients

Published
2005

4. Immunity Profiling of COVID-19 Infection, Dynamic Variations of Lymphocyte Subsets, a Comparative Analysis on Four Different Groups.

Author

Balzanelli MG, Distratis P, Dipalma G, Vimercati L, Catucci O, Amatulli F, Cefalo A, Lazzaro R, Palazzo D, Aityan SK, Pricolo G, Prudenzano A, D'Errico P, Laforgia R, Pezzolla A, Tomassone D, Inchingolo AD, Pham VH, Iacobone D, Materi GM, Scarano A, Lorusso F, Inchingolo F, Nguyen KCD, and Isacco CG

Abstract

Background: A novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) emerged in December 2019 in China, spreading worldwide. The aim of the present investigation was to evaluate the immunological response and the clinical subset of peripheral lymphocyte subset alteration in COVID-19 infection., Methods: the study was conducted on four different clinical groups ( n = 4; total n = 138). Each individual was assigned to different groups based on specific criteria evaluated at the admission such as fever, dyspnea, arterial blood gas analysis (ABG), oral-nasopharyngeal swab/RT-PCR, and thoracic CT-scan. Treatment was performed only after blood samples were collected from each patient (PP and PP) at day 1. The blood samples were analyzed and tested the same day (CBC and Flowcytometry). The positive-positive group (PP n = 45; F = 18/ M = 27; median age = 62.33), comprised individuals affected by COVID-19 who showed fever, dyspnea (ABG = pO2 < 60), confirmed positive by oral-nasopharyngeal swab/RT-PCR and with CT-scan showing ground-glass opacities. The negative-positive (NP; n = 37; F = 11/M = 26; median age = 75.94) or "COVID-like" group comprised individuals with fever and dyspnea (ABG = pO2 < 60), who tested negative to nasopharyngeal swab/RT-PCR, with CT-scans showing ground-glass opacities in the lungs. The negative-affected group (NA; n = 40; F = 14/M = 26; median age = 58.5) included individuals negative to COVID-19 (RT-PCR) but affected by different chronic respiratory diseases (the CT-scans didn't show ground-glass opacities). Finally, the negative-negative group (NN; n = 16; F = 14/M = 2) included healthy patients (NN; n = 16; median age = 42.62). Data and findings were collected and compared., Results: Lymphocytes (%) cells showed a decline in COVID-19 patients. The subsets showed a significant association with the inflammatory status in COVID-19, especially with regard to increased neutrophils, T-killer, T-active, T-suppressor, and T-CD8+CD38+ in individuals belong to the either COVID-19 and Covid-like NP group., Conclusions: Peripheral lymphocyte subset alteration was associated with the clinical characteristics and progression of COVID-19. The level of sub-set cells T-lymphocytes (either high or low) and B-lymphocytes could be used as an independent predictor for COVID-19 severity and treatment efficacy.

Published
2021
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5. Rituximab with peripheral blood stem cell transplantation in CD20 lymphoproliferative disorders.

Author

Mazza P, Palazzo G, Amurri B, Pricolo G, Prudenzano A, and Stani L

Subjects
Adult, Antibodies, Monoclonal, Murine-Derived, Female, Humans, Leukapheresis methods, Lymphoproliferative Disorders therapy, Male, Middle Aged, Neoplasm, Residual drug therapy, Remission Induction, Rituximab, Treatment Outcome, Antibodies, Monoclonal administration & dosage, Antigens, CD20, Antineoplastic Agents administration & dosage, Hematopoietic Stem Cell Transplantation methods, Lymphoproliferative Disorders drug therapy, Lymphoproliferative Disorders immunology
Published
2001

6. Fludarabine containing regimen followed by autologous peripheral blood stem cell transplantation in unselected patients with acute myeloid leukemia: a single center experience.

Author

Mazza P, Amurri B, Palazzo G, Prudenzano A, Pricolo G, and Stani L

Subjects
Acute Disease, Adolescent, Adult, Aged, Combined Modality Therapy, Female, Hematopoietic Stem Cell Mobilization, Humans, Male, Middle Aged, Transplantation, Autologous, Treatment Outcome, Vidarabine administration & dosage, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Hematopoietic Stem Cell Transplantation, Leukemia, Myeloid therapy, Vidarabine analogs & derivatives
Published
2000

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