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1. Fetal therapy guidelines of the Polish Society of Gynecologists and Obstetricians -- Fetal Therapy Section.

Author

Kosinski, Przemyslaw, Borowski, Dariusz, Brawura-Biskupski-Samaha, Robert, Cnota, Wojciech, Debska, Marzena, Drews, Krzysztof, Grzesiak, Mariusz, Jaczynska, Renata, Janiak, Katarzyna, Kaczmarek, Piotr, Lipa, Michal, Litwinska, Magdalena, Luterek, Katarzyna, Olejek, Anita, Polczynska-Kaniak, Emilia, Preis, Krzysztof, Szaflik, Krzysztof, Szymkiewicz-Dangel, Joanna, Swiatkowska-Freund, Malgorzata, and Wegrzyn, Piotr

Subjects
FETAL surgery, GYNECOLOGISTS, OBSTETRICIANS, EVIDENCE-based medicine, CYTOMEGALOVIRUS diseases
Published
2024
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4. High maternal-fetal HLA eplet compatibility is associated with severe manifestation of preeclampsia.

Author

Stefańska, Katarzyna, Kurkowiak, Małgorzata, Piekarska, Karolina, Chruściel, Elżbieta, Zamkowska, Dorota, Jassem-Bobowicz, Joanna, Adamski, Przemysław, Świątkowska-Stodulska, Renata, Abacjew-Chmyłko, Anna, Leszczyńska, Katarzyna, Zieliński, Maciej, Preis, Krzysztof, Zielińska, Hanna, Tymoniuk, Bogusław, Trzonkowski, Piotr, and Marek-Trzonkowska, Natalia Maria

Subjects
PREECLAMPSIA, BLOOD group incompatibility, HLA histocompatibility antigens, PREGNANCY outcomes, AMINO acid sequence
Abstract

Introduction: Preeclampsia is responsible for more than 70 000 and 500 000 maternal and fetal deaths, respectively each year. Incomplete remodelling of the spiral arteries in placenta is the most accepted theory of preeclampsia pathogenesis. However, the process is complexed with immunological background, as pregnancy resembles allograft transplantation. Fetus expresses human leukocyte antigens (HLA) inherited from both parents, thus is semiallogeneic to the maternal immune system. Therefore, induction of fetal tolerance is crucial for physiological outcome of pregnancy. Noteworthy, the immunogenicity of discordant HLA antigens is determined by functional epitopes called eplets, which are continuous and discontinuous short sequences of amino acids. This way various HLA molecules may express the same eplet and some HLA incompatibilities can be more immunogenic due to different eplet combination. Therefore, we hypothesized that maternal-fetal HLA incompatibility may be involved in the pathogenesis of gestational hypertension and its progression to preeclampsia. We also aimed to test if particular maternal-fetal eplet mismatches are more prone for induction of anti-fetal HLA antibodies in gestational hypertension and preeclampsia. Methods: High resolution next-generation sequencing of HLA-A, -B, -C, -DQB1 and -DRB1 antigens was performed in mothers and children from physiological pregnancies (12 pairs) and from pregnancies complicated with gestational hypertension (22 pairs) and preeclampsia (27 pairs). In the next step HLA eplet identification and analysis of HLA eplet incompatibilities was performed with in silico approach HLAMatchmaker algorithm. Simultaneously maternal sera were screened for anti-fetal HLA class I, class II and anti-MICA antibodies with Luminex, and data were analyzed with HLA-Fusion software. Results: We observed that high HLA-C, -B, and DQB1 maternal-fetal eplet compatibility was associated with severe preeclampsia (PE) manifestation. Both quantity and quality of HLA epletmismatches affected the severity of PE. Mismatches in HLA-B eplets: 65QIA+76ESN, 70IAO, 180E, HLA-C eplets: 193PL3, 267QE, and HLA-DRB1 eplet: 16Y were associated with a mild outcome of preeclampsia if the complication occurred. Conclusions: High HLA-C, HLA-DQB1 and HLA-B eplet compatibility between mother and child is associated with severe manifestation of preeclampsia. Both quantity and quality of maternal-fetal HLA eplet mismatches affects severity of preeclampsia. [ABSTRACT FROM AUTHOR]

Published
2023
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6. KIR- Ligand Interactions in Hypertensive Disorders in Pregnancy

Author

Stefańska, Katarzyna, primary, Tomaszewicz, Martyna, additional, Dębska-Zielkowska, Joanna, additional, Zamkowska, Dorota, additional, Piekarska, Karolina, additional, Sakowska, Justyna, additional, Studziński, Maciej, additional, Tymoniuk, Bogusław, additional, Adamski, Przemysław, additional, Jassem-Bobowicz, Joanna, additional, Wydra, Piotr, additional, Leszczyńska, Katarzyna, additional, Świątkowska-Stodulska, Renata, additional, Kwiatkowski, Sebastian, additional, Preis, Krzysztof, additional, Trzonkowski, Piotr, additional, Marek-Trzonkowska, Natalia, additional, and Zieliński, Maciej, additional

Published
2022
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8. Influence of Entonox (mixture of 50% nitrous oxide and 50% oxygen) on physiological labor and neonatal outcome in own material.

Author

Minowski, Piotr, Swiatkowska-Freund, Malgorzata, and Preis, Krzysztof

Subjects
NITROUS oxide, ANESTHESIA, EPISIOTOMY, OXYTOCIN, CONTROL groups
Abstract

Objectives: The aim of the study was to compare maternal and neonatal outcome of delivery with inhaled anesthesia to delivery without pain control. Material and methods: Authors performed retrospective analysis of 260 term deliveries. In the study group (130 women) a mixture of nitrous oxide and oxygen was used. The control group included 130 patients who used no pain relief during delivery. Results: In nulliparas the pain assessment in 11-points scale was similar in both groups, but the labor was longer (350 ± 152 vs 228 ± 113 minutes; p < 0.001 for the first stage and 46 ± 37 vs 18 ± 18 minutes; p < 0.001 for the second stage), episiotomy incidence was higher (81.4% vs 41.9%; p < 0.001) and perineal laceration lower (2.3% vs 25.7%; p < 0.001) in the study group. In multiparas the pain assessment was lower in the study group (5 vs 7 points; p = 0.006), oxytocin was administered more frequently (45.5% vs 21.4%, p = 0.011), but labor duration was the same in both groups. Episiotomy was more frequent (61.4% vs 37.5%, p = 0.02), but there was no difference in perineal laceration. Apgar score was the same in the study and control group. Conclusions: We found that Entonox prolongs labor significantly and increases frequency of episiotomy in primiparas with no clear analgesic effect. Offering Entonox to the patients giving birth for the first time is thus questionable. In multiparas it has a good analgesic effect but increases probability of episiotomy with no significant influence on perineal tear, what seems not very high cost of decreased pain related to delivery. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Perinatal and neonatal outcome in patients with preeclampsia

Author

Stefanska, Katarzyna A., primary, Zielinski, Maciej, additional, Jassem-Bobowicz, Joanna, additional, Zamkowska, Dorota, additional, Adamski, Przemyslaw, additional, Piekarska, Karolina, additional, Jankowiak, Martyna, additional, Leszczynska, Katarzyna, additional, Swiatkowska-Stodulska, Renata, additional, Preis, Krzysztof, additional, Trzonkowski, Piotr, additional, and Marek-Trzonkowska, Natalia, additional

Published
2022
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10. Recommendations for prenatal diagnostics of the Polish Society of Gynaecologists and Obstetricians and the Polish Society of Human Genetics

Author

Sieroszewski, Piotr, primary, Haus, Olga, additional, Zimmer, Mariusz, additional, Wielgos, Miroslaw, additional, Latos-Bielenska, Anna, additional, Borowiec, Maciej, additional, Borowski, Dariusz, additional, Cnota, Wojciech, additional, Czuba, Bartosz, additional, Dubiel, Mariusz, additional, Jakubowski, Lucjusz, additional, Janiak, Katarzyna, additional, Kaczmarek, Piotr, additional, Kwiatkowski, Sebastian, additional, Nowakowska, Beata, additional, Pietryga, Marek, additional, Piotrowski, Krzysztof, additional, Preis, Krzysztof, additional, Ropacka-Lesiak, Mariola, additional, Sasiadek, Maria M., additional, Swiatkowska-Freud, Malgorzata, additional, Wegrzyn, Piotr, additional, Wloch, Agata, additional, and Moczulska, Hanna, additional

Published
2022
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14. Cytokine Imprint in Preeclampsia

Author

Stefańska, Katarzyna, primary, Zieliński, Maciej, additional, Jankowiak, Martyna, additional, Zamkowska, Dorota, additional, Sakowska, Justyna, additional, Adamski, Przemysław, additional, Jassem-Bobowicz, Joanna, additional, Piekarska, Karolina, additional, Leszczyńska, Katarzyna, additional, Świątkowska-Stodulska, Renata, additional, Kwiatkowski, Sebastian, additional, Preis, Krzysztof, additional, Trzonkowski, Piotr, additional, and Marek-Trzonkowska, Natalia, additional

Published
2021
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15. Potential of DNA zygosity tests for non-invasive evaluation of risk of complications in twin pregnancies.

Author

Dziennik, Agnieszka, Preis, Krzysztof, Swiatkowska-Freund, Malgorzata, and Rebala, Krzysztof

Subjects
DNA analysis, ULTRASONIC imaging, GENOTYPES, PREGNANCY, UMBILICAL cord
Abstract

Objectives: To evaluate and compare the potential of DNA analysis and ultrasound examination for diagnosis of high-risk and low-risk twin pregnancies. Material and methods: Chorionicity of 42 twin pregnancies was determined by routine high-resolution sonographic examination between 10 and 14 weeks of gestation. Zygosity was analysed in umbilical cord blood samples collected immediately after the birth by genotyping of 22 autosomal short tandem repeats used in human identity testing. Results: Routine ultrasound imaging in the first trimester of twin gestations revealed 21 low-risk dichorionic (50%) and 21 high-risk monochorionic pregnancies (50%). DNA typing of umbilical cord blood showed 23 twin pairs with different genotypes (low-risk dizygotic pregnancies, 55%) and 19 twin pairs with identical genotypes (high-risk monozygotic pregnancies, 45%). We found four pregnancies (10%), which were diagnosed sonographically as monochorionic diamniotic, but were identified as dizygotic in postnatal DNA testing. They constituted 19% of all high-risk monochorionic pregnancies detected by ultrasound imaging. Conclusions: Our results indicate high potential of prenatal DNA testing of zygosity in identification of low-risk and high-risk twin gestations requiring different prenatal care, especially in cases when chorionicity and zygosity cannot be reliably determined by ultrasound examination and as a supplementary test able to detect gestations misdiagnosed as monochorionic, resulting from fusions of dizygotic placentas. In such cases, dizygosity detected prenatally eliminates the need for frequent prenatal visits typical for monochorionic pregnancies. If chorionicity cannot be unequivocally determined and a prenatal DNA test detects monozygotic twins, a more pessimistic variant of monochorionic pregnancy should always be assumed. [ABSTRACT FROM AUTHOR]

Published
2022
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16. Comparisons of Dipstick Test, Urine Protein-to-Creatine Ratio, and Total Protein Measurement for the Diagnosis of Preeclampsia

Author

Stefańska, Katarzyna, primary, Zieliński, Maciej, additional, Zamkowska, Dorota, additional, Adamski, Przemysław, additional, Jassem-Bobowicz, Joanna, additional, Piekarska, Karolina, additional, Jankowiak, Martyna, additional, Leszczyńska, Katarzyna, additional, Świątkowska-Stodulska, Renata, additional, Preis, Krzysztof, additional, Trzonkowski, Piotr, additional, and Marek-Trzonkowska, Natalia, additional

Published
2020
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17. Screening for maternal postpartum depression and associationswith personality traits and social support. A Polish follow-upstudy 4 weeks and 3 months after delivery

Author

Małgorzata Świątkowska-Freund, Karolina Maliszewska, Mariola Bidzan, and Preis Krzysztof

Subjects
Adult, Postpartum depression, medicine.medical_specialty, media_common.quotation_subject, Breastfeeding, Mothers, Risk Assessment, Depression, Postpartum, Young Adult, 03 medical and health sciences, Social support, 0302 clinical medicine, Risk Factors, medicine, Humans, Mass Screening, Personality, 030212 general & internal medicine, Psychiatry, media_common, Pregnancy, 030219 obstetrics & reproductive medicine, Postpartum Period, Social Support, General Medicine, medicine.disease, Neuroticism, Psychiatry and Mental health, Mental Health, Edinburgh Postnatal Depression Scale, Female, Poland, Personality Assessment Inventory, Psychology, Follow-Up Studies, Clinical psychology
Abstract

Cel pracyCelem pracy była ocena rozpowszechnienia ryzyka depresji poporodowej oraz próba scharakteryzowania matek zagrożonych depresją pod kątem osobowości, wsparcia społecznego i innych danych medycznych oraz psychologicznych.MetodaPrzebadano grupę 548 pacjentek w pierwszym tygodniu połogu, a następnie 4 tygodnie i 3 miesiące po porodzie. Matki wypełniły ankiety, które zawierały pytania dotyczące danych socjodemograficznych i medycznych oraz testy: EPDS (Edynburska Skala Depresji Poporodowej), PHQ-9 (Kwestionariusz Zdrowia Pacjenta-9), NEO-FFI (Inwentarz Osobowości) i BSSS (Berlińskie Skale Wsparcia Społecznego).WynikiPrawdopodobieństwo depresji poporodowej w trakcie pierwszych 3 miesięcy po porodzie stwierdzono u 6,38% kobiet, przyjmując następujące kryteria: EPDS>12 punktów oraz PHQ-9>9 punktów. Wynik EPDS>9 punktów w pierwszym tygodniu połogu (ORa=4,16; CI 1,59-10,86), hospitalizacja w trakcie ciąży (ORa=3,51; CI 1,32-9,20), wysoki poziom neurotyczności (ORa=1,37; CI 1,05-1,77) oraz wysokie wsparcie buforująco-ochronne (ORa=2,56; CI 1,25-5,23) znacząco zwiększały ryzyko objawów depresyjnych. Do potencjalnych czynników ochronnych zaliczyć można początkowe karmienie piersią (ORa=0,31; CI 0,11-0,90) oraz satysfakcja z otrzymywanego wsparcia społecznego (ORa=0,41; CI 0,22-0,79). Odsetek kobiet rezygnujących z badania wyniósł 23%.WnioskiMatki cechujące się wysokim poziomem neurotyczności, oraz te, które doświadczyły fizycznych i psychicznych problemów w czasie ciąży i połogu mają wyższe ryzyko depresji poporodowej. Kobiety te chronią swoich bliskich przed złymi informacjami o nich samych. Podobną rolę odgrywa brak początkowego karmienia piersią oraz niezadawalające wsparcie społeczne.

Published
2017

21. Cervical elastography during pregnancy: clinical perspectives

Author

Swiatkowska-Freund,Malgorzata and Preis,Krzysztof

Subjects
International Journal of Women's Health
Abstract

Malgorzata Swiatkowska-Freund, Krzysztof Preis Department of Obstetrics, Medical University of Gdansk, Gdansk, Poland Abstract: Uterine cervix is a part of the uterus responsible for maintaining pregnancy till term. As long as the cervix remains long and firm and its internal orifice (os) is closed, it can withstand enlargement of the uterine contents and resultant growing pressure. Mechanical properties of the cervix change during pregnancy; the cervix ripens prior to delivery, then effaces and dilates with contractions of the uterus. Ripening of the cervix can be assessed using the Bishop score and ultrasonographically determined length of the cervical canal and internal os. Consistency is one of the cervical properties that change during the course of the maturation process. Until recently, cervical consistency has been assessed only manually, but in 2007, the first report on elastographic imaging of the cervix during pregnancy has been published. Elastography presents the ability of a tissue to deform under pressure. The softer the tissue, the easier it changes its shape. Different methods of elastography are used – static, when tissue displacement in response to manual compression or physiological movements of vessels is measured, or dynamic, when the speed of shear wave propagation is determined. Irrespective of the method, elastography provides information on the internal os stiffness; this parameter, impossible for manual assessment, was shown to correlate with pregnancy outcome and is a strong predictor of preterm delivery or successful labor induction. Although elastography seems to be a highly promising diagnostic option, still no consensus has been reached regarding an optimal method for uterine cervix assessment, and virtually all previous studies of various elastographic methods produced highly satisfactory results. Future studies need to identify the most promising and objective elastographic method which may serve as a novel tool for pregnancy management, preventing adverse events, such as preterm delivery and unsuccessful labor induction. Keywords: consistency, elastography, labor induction, preterm delivery, uterine cervix

Published
2017

22. Influence of Gestational Age at Initiation of Antihypertensive Therapy

Author

Pels, Anouk, primary, Mol, Ben Willem J., additional, Singer, Joel, additional, Lee, Terry, additional, von Dadelszen, Peter, additional, Ganzevoort, Wessel, additional, Asztalos, Elizabeth, additional, Magee, Laura A., additional, Gafni, Amiram, additional, Gruslin, Andrée, additional, Helewa, Michael, additional, Hutton, Eileen, additional, Lee, Shoo, additional, Logan, Alexander, additional, Menzies, Jennifer, additional, Moutquin, Jean-Marie, additional, Murphy, Kellie, additional, Rey, Evelyne, additional, Ross, Sue, additional, Sanchez, Johanna, additional, Thornton, Jim G., additional, Welch, Ross, additional, Hoac, Trinh, additional, Kirton, Joanne, additional, Trigiani, Katherine, additional, Zahid, Ainy, additional, Bracken, Michael B., additional, Crowley, Patricia, additional, Duley, Lelia, additional, Ehrenkranz, Richard, additional, Thorpe, Kevin, additional, Chan, Sunny, additional, Shi, Michael, additional, Yu, Shelley, additional, de Lourdes Martin, Raquel, additional, Bassi, Maria Florencia, additional, Caruso, Mirta Clara, additional, Lagunas, Valeria, additional, Vera, Fernando, additional, Mohedano de Duhalde, Maria, additional, Roque, Alicia Beatriz, additional, Roldan, Patricia, additional, Duhalde, Esteban Marcos, additional, Dip, Viviana, additional, Aguirre, Jesus Daniel, additional, Morales, Elba Mirta Alicia, additional, Abreo, Griselda Itati, additional, De Sagastizabal, Teresa, additional, Gomez, Carolina, additional, Rizzi, Nadia, additional, Arias, Carlos, additional, Bruno, Ricardo Antonio, additional, Mahomed, Kassam, additional, Drew, Alison, additional, Green, Ann, additional, Hoare, Jane, additional, Hague, Bill, additional, Coat, Suzette, additional, Crowther, Caroline, additional, Muller, Peter, additional, Trenowden, Sophie, additional, Walters, Barry, additional, Parker, Claire, additional, Graham, Dorothy, additional, Pennell, Craig, additional, Sung, Eileen, additional, Makris, Angela, additional, Lee, Gaksoo, additional, Thornton, Charlene, additional, Hennessy, Annemarie, additional, Farrell, Louise, additional, Sass, Nelson, additional, Korkes, Henri, additional, Ferreira, Dayana Couto, additional, Moreira de Sa, Renato Augusto, additional, Abreu, Monique Schmidt Marques, additional, Bornia, Rita Guerios, additional, da Silva, Nancy Ribeiro, additional, Cardoso, Fernanda Freitas Oliveira, additional, Marques, Caio Coelho, additional, Hornos, Jorge, additional, Davdt, Ricardo Leal, additional, Paula, Letícia Germany, additional, Zanella, Pedro Luis, additional, Inglis, Gabrielle, additional, Dillon, Ruth, additional, Docherty, Ashley, additional, Hutfield, Anna, additional, Still, Keith, additional, Lalji, Sayrin, additional, Van Tent, Tamara, additional, Hotz, Chris, additional, Messmer, Tracy, additional, Ray, Joel G., additional, Berger, Howard, additional, De Souza, Leanne, additional, Lausman, Andrea, additional, Freire-Lizama, Tatiana, additional, Besel, Kate, additional, Gibson, Paul, additional, Ellsworth, Greta, additional, Miller, Leslie, additional, Hawkins, T. Lee-Ann, additional, Hladunewich, Michelle, additional, Rogowsky, Anna, additional, Hui, Dini, additional, Collins, Virginia, additional, Delisle, Isabelle, additional, Fanning, Cora, additional, Demianczuk, Nestor, additional, Khurana, Rshmi, additional, Sia, Winnie, additional, Marnoch, Catherine, additional, Young, Carmen, additional, Lux, Cheryl, additional, Perreault, Sophie, additional, Tremblay, Valerie, additional, Desindes, Sophie, additional, Côté, Anne-Marie, additional, Dagenais, Veronique, additional, Clark, Heather, additional, O’Shea, Elaine, additional, White, Ruth Rennicks, additional, Gandhi, Shital, additional, Martin, Mary-Jean, additional, Brush, Cheryl, additional, Seaward, Gareth, additional, Newstead-Angel, Jill, additional, Brandt, Judy, additional, Martel, Jocelyne, additional, Mytopher, Kristine, additional, Buschau, Elise, additional, Keely, Erin, additional, Waddell, Patti, additional, Shachkina, Svetlana, additional, Karovitch, Alan, additional, Anderson, Robert, additional, Koenig, Nicole, additional, Yong, Theresa, additional, Vasiliou, Marie, additional, Johnson, Peri, additional, Allan, Beth, additional, Natale, Renato, additional, Kennedy, Laura, additional, Opatrny, Lucie, additional, Lavigne, Lorraine, additional, Carson, George, additional, Kelly, Sheila, additional, Crane, Joan, additional, Hutchens, Donna, additional, Kusanovic, Juan Pedro, additional, Figueroa, Christian, additional, Neculman, Karla Silva, additional, Ortiz, Juan Andres, additional, Vargas, Paula, additional, Ferrand, Pedro, additional, Carrillo, Jorge, additional, Borrero, Rodrigo Cifuentes, additional, Gallo, Dahiana Marcela, additional, Moreno, Luisa Fernanda, additional, Kirss, Fred, additional, Rull, Kristiina, additional, Kirss, Anne, additional, Major, Tamas, additional, Fodor, Andrea, additional, Bartha, Tunde, additional, Hallak, Mordechai, additional, Aslih, Nardin, additional, Anabousi-Murra, Saja, additional, Pri-Or, Ester, additional, Harel, Linda, additional, Siev, Sima, additional, Hakim, Marwan, additional, Khoury, Christina Simona, additional, Hamati, Najla, additional, El-Zibdeh, Mazen, additional, Yousef, Lama, additional, Hughes, Ruth, additional, Leishman, Di, additional, Pullar, Barbra, additional, Farrant, Matthew, additional, Swiatkowska-Freund, Malgorzata, additional, Preis, Krzysztof, additional, Traczyk-Los, Anette Aleksandra, additional, Partyka, Anna, additional, Preis-Orlikowska, Joanna, additional, Lukaszuk, Mariusz, additional, Krasomski, Grzegorz, additional, Krekora, Michael, additional, Kedzierska-Markowicz, Anna, additional, Zych-Krekora, Katarzyna, additional, Breborowicz, Grzegorz H., additional, Dera-Szymanowska, Anna, additional, Bakker, Jannet, additional, Akkermans, Joost, additional, van den Akker, Eline, additional, Logtenberg, Sabine, additional, Koenen, Steven, additional, de Reus, Maartje, additional, Borman, David, additional, Oudijk, Martijn A., additional, Bolte, Annemiek, additional, Verfaille, Viki, additional, Graaf, Bart, additional, Porath, Martina, additional, Verhoeven, Corine, additional, Franssen, Maureen T.M., additional, Ulkeman, Lida, additional, Hamming, Ineke, additional, Keurentjes, Jose H.M., additional, van der Wal, Ina, additional, Bijvank, S.W.A. Nij, additional, Lutjes, A.A., additional, Visser, Henricus, additional, Scheepers, Hubertina Catharina Johanna, additional, van Beek, Erik, additional, van Dam, Coby, additional, van den Berg-Swart, Kathy, additional, Pernet, Paula, additional, van der Goes, Birgit, additional, Schuitemaker, Nico, additional, Kleiverda, Gunilla, additional, van Alphen, Marcel, additional, Rosman, Ageeth, additional, Gaugler-Senden, Ingrid, additional, Linders, Marieke, additional, Nelson-Piercy, Catherine, additional, Briley, Annette, additional, Soh, May Ching, additional, Harding, Kate, additional, Tarft, Hayley, additional, Churchill, David, additional, Cheshire, Katherine, additional, Icke, Julia, additional, Ghosh, Mausumi, additional, Thornton, James, additional, Toomassi, Yvonne, additional, Barker, Karen, additional, Fisher, Joanne, additional, Grace, Nicky, additional, Green, Amanda, additional, Gower, Joanne, additional, Molnar, Anna, additional, Parameshwaran, Shobhana, additional, Simm, Andrew, additional, Bugg, George, additional, Davis, Yvette, additional, Desphande, Ruta, additional, Gunn, Yvette, additional, Houda, Mohammed, additional, Jones, Nia, additional, Waugh, Jason, additional, Allan, Carly, additional, Waring, Gareth, additional, Walkinshaw, Steve A., additional, Pascall, Angela, additional, Clement-Jones, Mark, additional, Dower, Michelle, additional, Houghton, Gillian, additional, Longworth, Heather, additional, Purewal, Tej, additional, Tuffnell, Derek, additional, Farrar, Diane, additional, Syson, Jennifer, additional, Butterfield, Gillian, additional, Jones, Vicky, additional, Palethorpe, Rebecca, additional, Germaine, Tracey, additional, Habiba, Marwan, additional, Lee, Debbie, additional, Eniola, Olufemi, additional, Blake, Lynne, additional, Khan, Jane, additional, Cameron, Helen M., additional, Hinshaw, Kim, additional, Bargh, Amanda, additional, Walton, Eileen, additional, Sorinola, Olanrewaju, additional, Guy, Anna, additional, D’Souza, Zoe, additional, Gabriel, Rhiannon, additional, Williams, Jo, additional, Hollands, Heidi, additional, Jibodu, Olujimi, additional, Collier, Sara, additional, Tottie, Pauline, additional, Oxby, Claire, additional, Dwyer, James, additional, Majoko, Franz, additional, Goldring, Helen, additional, Jones, Sharon, additional, Cresswell, Janet, additional, Underwood, Louise, additional, Kelly-Baxter, Mary, additional, Robinson, Rebecca, additional, Anumba, Dilly, additional, Chamberlain, Anne, additional, Pye, Clare, additional, Tower, Clare, additional, Woods, Sue, additional, Horrocks, Lisa, additional, Prichard, Fiona, additional, Moorhead, Lynsey, additional, Lee, Sarah, additional, Stephens, Louise, additional, Taylor, Cara, additional, Thomas, Suzanne, additional, Whitworth, Melissa, additional, Myers, Jenny, additional, Knox, Ellen, additional, Freitas, Katie, additional, Kilby, Mark, additional, Cotterill, Amanda, additional, Abdo, Khalil, additional, Rigby, Katrina, additional, Butler, Julie, additional, Crosfill, Fiona, additional, Hughes, Sean, additional, Prashar, Sanjeev, additional, Soydemir, Fatimah, additional, Ashworth, Janet, additional, Mycock, Lorraine, additional, Smith, Jill, additional, Ikomi, Amaju, additional, Goodsell, Kerry, additional, Byrne, Jean, additional, Masuku, Maxwell, additional, Pilcher, Alice, additional, Khandelwal, Meena, additional, Simpkins, Gunda, additional, Iavicoli, Michelle, additional, Kim, Yon Sook, additional, Fischer, Richard, additional, Perry, Robin, additional, Chang, Eugene Y., additional, Saunders, Tamara D., additional, Oswald, Betty W., additional, Zaks, Kristin D., additional, Rana, Sarosh, additional, McCullough, Dawn, additional, Sfakianaki, Anna, additional, Danton, Cheryl, additional, Kustan, Erin, additional, Coraluzzi, Luisa, additional, How, Helen, additional, Waldon, Christina, additional, Livingston, Jeffrey, additional, Jackson, Sherry, additional, Greene, Lisa, additional, Shah, Dinesh, additional, Tolosa, Jorge E., additional, Rincon, Monica, additional, Pereira, Leonardo, additional, Lawrence, Amy E., additional, Snyder, Janice E., additional, Armstrong, D. Michael, additional, Blue, Teresa, additional, Hester, Austin, additional, and Salisbury, Kathryn, additional

Published
2018
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26. Association between uridin diphosphate glucuronosylotranserase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia

Author

Mazur - Kominek, Katarzyna, primary, Romanowski, Tomasz, primary, Bielawski, Krzysztof, primary, Kiełbratowska, Bogumiła, primary, Preis, Krzysztof, primary, Domżalska - Popadiuk, Iwona, primary, Słomińska - Frączek, Magdalena, primary, Sznurkowska, Katarzyna, primary, Renke, Joanna, primary, Plata-Nazar, Katarzyna, primary, Śledzińska, Karolina, primary, Sikorska - Wiśniewska, Grażyna, primary, Góra - Gębka, Magdalena, primary, and Liberek, Anna, primary

Published
2017
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29. Pregnancy and Delivery in Patients with Mastocytosis Treated at the Polish Center of the European Competence Network on Mastocytosis (ECNM)

Author

Ciach, Katarzyna, primary, Niedoszytko, Marek, additional, Abacjew-Chmylko, Anna, additional, Pabin, Izabela, additional, Adamski, Przemyslaw, additional, Leszczynska, Katarzyna, additional, Preis, Krzysztof, additional, Olszewska, Hanna, additional, Wydra, Dariusz G., additional, and Hansdorfer-Korzon, Rita, additional

Published
2016
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31. A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia

Author

Zabul, Piotr, primary, Wozniak, Michal, additional, Slominski, Andrzej, additional, Preis, Krzysztof, additional, Gorska, Magdalena, additional, Korozan, Marek, additional, Wieruszewski, Jan, additional, Zmijewski, Michal, additional, Zabul, Ewa, additional, Tuckey, Robert, additional, Kuban-Jankowska, Alicja, additional, Mickiewicz, Wieslawa, additional, and Knap, Narcyz, additional

Published
2015
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35. Rekomendacje Polskiego Towarzystwa Ginekologicznego dotyczące postępowania w zakresie diagnostyki prenatalnej

Author

Kotarski, Jan, Wielgoś, Mirosław, Brązert, Jacek, Czajka, Ryszard, Czekierdowski, Artur, Drews, Krzysztof, Niemiec, Tomasz, Poręba, Ryszard, Preis, Krzysztof, Radowicki, Stanisław, Sieroszewski, Piotr, Szaflik, Krzysztof, Szymański, Wiesław, Wołczyński, Sławomir, Zimmer, Mariusz, Borowski, Dariusz, Celewicz, Zbigniew, Dubiel, Mariusz, Kaczmarek, Piotr, Pietryga, Marek, Sodowski, Krzysztof, Basta, Paweł, Cnota, Wojciech, Czuba, Bartosz, Piotrowski, Krzysztof, and Węgrzyn, Piotr

Subjects
prenatal diagnosis, chromosomal abnormalities, screening, guideline
Published
2009

37. “Planned” permanent pacemaker implantation in one-day-old newborn after prenatal diagnosis of congenital complete atrioventricular heart block

Author

Haponiuk, Ireneusz, primary, Chojnicki, Maciej, additional, Szofer-Sendrowska, Aneta, additional, Juscinski, Jacek, additional, Steffens, Mariusz, additional, Jaworski, Radoslaw, additional, Domzalska-Popadiuk, Iwona, additional, Gierat-Haponiuk, Katarzyna, additional, Leszczynska, Katarzyna, additional, and Preis, Krzysztof, additional

Published
2014
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45. Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS): The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study

Author

Murphy, Kellie E., Hannah, Mary E., Willan, Andrew R., Ohlsson, Arne, Kelly, Edmond N., Matthews, Stephen G., Saigal, Saroj, Asztalos, Elizabeth, Ross, Sue, Delisle, Marie-France, Tomat, Laura, Amankwah, Kofi, Guselle, Patricia, Gafni, Amiram, Lee, Shoo K., Anthony Armson, B., Group, for the MACS Collaborative, Murphy, Kellie E., Amankwah, Kofi, Armson, B. Anthony, Asztalos, Elizabeth, Delisle, MarieFrance, Gafni, Amiram, Guselle, Patricia, Hannah, Mary E., Hewson, Sheila A., Kelly, Edmond N., Lee, Shoo K., Matthews, Stephen G., Ohlsson, Arne, Ross, Sue, Rovet, Joanne, Saigal, Saroj, Sananes, Renee, Schmid, Isabelle, Willan, Andrew R., Kwiatkowski, Leonardo, Tortorella, Susana Marisa, Bertin, Marta Susana, Castaldi, José Luis, Deguer, Carlos, Klun, Milton, Besegato, Cintia, Izbizky, Gustavo, Vaneri, Maria Cristina, Fustinana, Carlos Alberto, Otano, Lucas, Palermo, Mario S.F., Murua, Emerson Javier, Valera, Dolores Montes, Sampietro, Hector, Monaco, Antonio, Savransky, Argentina Ricardo, Dunaiewsky, Armando, Basualdo, Maria Natalia, Andina, Elsa, Di Marco, Ingrid, Rivero, Mabel, Feu, Maria Celeste, Garcia, Sergio, Aguirre, Jesus Daniel, Morales, Elba Mirta, Ayala, Liana Elisa, De Sagastizabal, Maria Teresa, Abreo, Griselda, Uranga, Alfredo, Martin, Raquel de Lourdes, Arias, Carlos, Gorostiaga, Raul Abalos, Curioni, Miguel, Alvarado, Jorge, Fuchtner, Carlos, Flores, Desiree Mostajo, Tonoli Tessari, Dilma Maria, Madi, Jose Mauro, de Lorenzi, Dino Roberto Soares, Mattana, Maria do Carmo, Brunstein, Carla, Trapani, Alberto, Schmaltz, Luiza, de Souza, Goianice Ribero, de Assis, Maria Elaine, Melo Melgaco, Irene Angela, Moreira de Sa, Renato Augusto, Bornia, Rita Guerios, Demianczuk, Nestor N, Penttinen, Elizabeth, Butt, Kimberly, Hay, Kathryn, Sandwich, Vicki, Armson, B Anthony, Vincer, Michael, Allen, Victoria, Fanning, Cora, Kulkarni, Ramesh, Laplante, Joanne, Carson, George D, Williams, Suzanne, Holfeld, Sandy, Olatunbosun, Femi, Dalton, Shirley, Henry, April, Haughian, Janna, Moutquin, Jean-Marie, Blouin, Daniel, Bédard, Suzanne Kocsis, Murphy, Kellie, Ohlsson, Arne, Kelly, Edmond, Jordan, Anne, Shapiro, Jodi, Asztalos, Elizabeth, Barrett, Jon, Cohen, Howard, Andrews, Leigh, Owen, Holly, Delisle, Marie-France, Popovska, Vesna, Soanes, Shelley, Helewa, Michael E, Kenny-Lodewyks, Doris, Gomez, Ricardo, Silva, Karla, Poblete, Jorge Figueroa, Ferrand, Pedro, Belmar, Cristian, Vera, Claudio, Su, Qi Feng, Gu, Wei, Liu, Zhi Wei, Flores, Martha Marrugo, Santoro, Carlos Malabet, Ortiz, Edgar Ivan, Torres, Javier, Rodriguez, Adriana, Hvidman, Lone, Mouritzen, Anne, Vikre-Jørgensen, Jennifer, Hopp, Hartmut, Nonnenmacher, Andreas, Braig, Ute, Berg, Christoph, Bizjak, Gabriele, Gembruch, Ulrich, Schwarzer, Verena, Hoyme, U B, Bittrich, Hans-Jorg, Oletzky, Britta, Schneider, Joachim, Hollwitz, Bettina, Oehler, Katrin, Dressler, Frank, Ertan, A Kubilay, Hentschel, Juliane, Mack, Annegret, Schmidt, W., Faber, Renaldo, Stepan, Holger, Kuhnert, Maritta, Stiller, Susanne, Kuschel, Bettina, Schneider, K.T.M., Zimmermann, Andrea, Krause, Michael, Gröbe, H, Terzioglu, Neslisah, Seelbach-Goebel, Birgit, Falkert, Andreas, Mueller, Karin, Voss, Hana, Major, Tamas, Zoärd, Krasznai, Bartha, Tünde, Bea, Polonkai, Zsadänyi, Judit, Nachum, Zohar, Peniakov, Marina, Hallak, Mordechai, Harlev, Avraham, Harel, Linda, Chayen, Benny, Siev, Sima, Samberg, Ichel, Wolff, Leslie, Sadan, Oscar, Elyassi, Anat, Baider, Carolina, Kohelet, David, Golan, Abraham, Mankuta, David, Bar-Oz, Benjamin, Combs, Danielle, Rosen, Doron J.D., Kaneti, Hagai Y., Tzachi, Tal, Zausmer, Janice, Maman, Maor, Perri, Tamar, Taitelboum, Shani, Simchen, Michal, Shalev, Gilat, Goldinfeld, Michael, Levine, Orit, El-Zibdeh, Mazen Y, Al-Faris, Lama T, Ayyash, Hussein A, Ugarte, Pedro Saona, Preis, Krzysztof, Domzalska-Popadiuk, Iwona, Swiatkowska-Freund, Malgorzata, Janczewska, Iwona, Wilczynski, Jan, Krekora, Michael, Kesiak, Marcin, Gulczynska, Ewa, Ropacka, Mariola, Madejczyk, Mateusz, Rozycka, Joanna, Breborowicz, Grzegorz H, Szymankiewicz, Marta, Borzova, Nadezhda, Posiseeva, Lubov V, Khodjaeva, Zulfiya, Vikhlyaeva, Ekaterina, Palacio, Montse, Salvia, Dolors, Botet, Francesc, Massanes, Marta, Lopez, Marta, Hösli, Irene, Holzgreve, Wolfgang, Voekt, Cora A., Belhia, Fadhil, Hohlfeld, Patrick, Prince-dit-Clottu, Edmond, Beinder, Ernst, von Mandach, Ursula, Fauchere, Jean-Claude, Roumen, Frans J.M.E., Pieters, Mijntje, Smits, Frans, Bolaji, Ibrahim I, Adiotomre, Pauline, Al-Taher, Hamed, Barnes, Hayley, Abdul-Kadir, Rezan, Chi, Claudia, Van Someren, Vivienne, Dexter, Scott, Samelson, Renee, Horgan, Michael J, Valentini, Cathryn, Pardanani, Setul, Bebbington, Michael, Chazotte, Cynthia, Kilpatrick, Sarah, Drahos, Jessica L., Saldana, Luis, Mount, Beverly, Warner, Barbara, Wedig, Kathy, Lysikiewicz, Andrzej, Bsat, Fadi, Fleming, Jennie, Lee, Alison, Hoffman, Despina, Bracken, Michael, Crowley, Patricia, Donner, Allan, Duley, Lelia, and Tyson, Jon

Abstract

A single course of antenatal corticosteroids (ACS) is associated with a reduction in respiratory distress syndrome and neonatal death. Multiple Courses of Antenatal Corticosteroids Study(MACS), a study involving 1858 women, was a multicentre randomized placebo-controlled trial of multiple courses of ACS, given every 14 days until 33+6 weeks or birth, whichever came first. The primary outcome of the study, a composite of neonatal mortality and morbidity, was similar for the multiple ACS and placebo groups (12.9% vs. 12.5%), but infants exposed to multiple courses of ACS weighed less, were shorter, and had smaller head circumferences. Thus for women who remain at increased risk of preterm birth, multiple courses of ACS (every 14 days) are not recommended. Chronic use of corticosteroids is associated with numerous side effects including weight gain and depression The aim of this postpartum assessment was to ascertain if multiple courses of ACS were associated with maternal side effects.

Published
2011
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46. Couvade Syndrome among Polish expectant fathers

Author

Kazmierczak, Maria, Bogumiła Kiełbratowska, Pastwa-Wojciechowska, Beata, and Preis, Krzysztof

Subjects
Adult, Male, medicine.medical_specialty, Couvade syndrome, media_common.quotation_subject, MEDLINE, Empathy, Couvade Syndrome, Fathers, Clinical Research, Pregnancy, Humans, Medicine, Abnormalities, Multiple, empathy, Psychiatry, media_common, business.industry, Syndrome, General Medicine, medicine.disease, Female, Poland, business, Couvade
Abstract

Background The aim of the conducted study was to analyze the phenomenon of Couvade Syndrome amongst fathers expecting their children in Poland. The authors examined the frequency of couvade symptoms in male subjects as well as their associations with male empathy. Material/Methods The research involved 143 expectant fathers. All subjects attended antenatal classes, and their female partners were in their third trimester. Before the start of classes, participants were asked to fill in the following questionnaires: a survey for measurement of Couvade Syndrome (which includes a set of 16 symptoms identified by Lipkin and Lamb (19) and translated into Polish), and the Empathic Sensitiveness Scale (SWE). Although participants, on average, did not experience Couvade Syndrome, they did experience symptoms that are commonly linked with the syndrome, namely those related to weight (weight gain, changes in appetite and flatulence). Results The results indicate that expectant fathers experience couvade symptoms related to weight (weight gain, changes in appetite and flatulence). The only empathic component that positively correlates with Couvade Syndrome is personal distress, i.e. the tendency to take on the negative emotions of others. Demographic characteristics are not associated with Couvade Syndrome. Conclusions The frequency of couvade symptoms in male subjects is associated with male empathy. In other words, men who are emotionally sensitive or prone to distress may physiologically experience the pregnancy of their female partners, which can be interpreted as compathy.

49. Perinatal and neonatal outcome in patients with preeclampsia.

Author

Stefanska KA, Zielinski M, Jassem-Bobowicz J, Zamkowska D, Adamski P, Piekarska K, Jankowiak M, Leszczynska K, Swiatkowska-Stodulska R, Preis K, Trzonkowski P, and Marek-Trzonkowska N

Abstract

Objectives: Preeclampsia (PE) affects 2-5% of pregnant women. Hypertensive disorders of pregnancy are associated with adverse maternal and perinatal outcomes., Material and Methods: This study included 88 women showing gestational hypertension (GH) or PE symptoms, and their newborns., Results: The rate of FGR was 43% for mothers with PE, compared to 8% with GH. The association was significant, p = < 0.001 but with moderate strength, Cramer's V = 0.40. The risk of FGR increased nine times when PE occurred, as the odds ratio was 9.25 (CI: 2.46-34.83), p = 0.001. PE was associated with FGR risk if delivery time was less than 34 weeks compared to a delivery time of more than 34 weeks. This was 82% of FGR cases for < 34 weeks, compared with 35% of cases in > 34 group, (p = 0.001; Cramer's V = 0.50). PE was also associated (p = 0.01, Cramer's V = 0.27) with the type of delivery, as the caesarean section rate was 74%, compared to 50% in the GH group. This made it three times higher the likelihood of delivery by caesarean section, as the odds ratio was 3.10 (CI: 1.24-7.75), p=0,02. Delivery time was significantly (p < 0.001) shortened to 38 weeks (27-41), compared to 40 weeks (38-42) GH mothers. There was no distinction in median age for PE and GH mothers (p = 0.124). The overall clinical status of neonates was proportional despite the mother's PE. The sum of Apgar points in the first, and then the second to third minute, did not differ significantly, p = 0.370 and 0.560, respectively. The number of peripheral blood platelets and leucocytes was not reduced (p = 0.821 and 0.534) in infants when the mother suffered from PE., Conclusions: The prediction of adverse maternal outcomes from hypertensive diseases of pregnancy is key to optimal management, including the timing of delivery and planning for the most appropriate place of care.

Published
2021
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50. Diversity of dendritic cells generated from umbilical cord or adult peripheral blood precursors.

Author

Szaryńska M, Preis K, Zabul P, and Kmieć Z

Abstract

Following the discovery of methods to generate large numbers of specific dendritic cells (DCs) ex vivo, the possibility of exploiting these cells in immunotherapeutic strategies will become a reality. It seems to be rationally to analyse the influence of the precursor source for further features and applications. For the needs of the given project DCs were derived from precursors derived from adult peripheral blood (APB) and umbilical cord blood (UCB). During some expansions of UCB CD34 + cells were separated giving non-adherent DCs (NA-DCs) or adherent DCs (A-DCs), whereas DCs derived from UCB precursors without separation gave rise to All-DCs. DC subpopulations were stimulated by lipopolysaccharides (LPS) or interferon- γ (IFN- γ ), and afterwards the morphology, phenotype, and stimulatory properties were analysed. Our findings demonstrated that DCs generated from APB and UCB precursors were not equivalent and exhibited opposite features when expanded in comparable conditions. Additionally, all three subpopulations of UCB-derived DCs presented functional dissimilarities. Based on our results we concluded that the precursor source and the composition of media must be considered as crucial to the success of potential therapeutic application., Competing Interests: The authors declare no conflict of interest.

Published
2018
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