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3. Early childhood height-adjusted total kidney volume as a risk marker of kidney survival in ARPKD

Author

Nalcacioglu, Hulya, Dunand, Oliver, Mastrangelo, Antonio, Murer, Luisa, Emma, Francesco, Ruzgiene, Dovile, Taranta-Janusz, Katarzyna, Balasz-Chmielewska, Irena, Miklaszewska, Monika, Stanczyk, Malgorzata, Sikora, Przemyslaw, Kowalewska, Claudia, Szczepanska, Maria, Teixeira, Ana, Rachisan, Andreea, Papachristou, Fotios, Paripović, Dušan, Prikhodina, Larisa, Jilani, Houweyda, Bayazit, Aysun Karabay, Soylu, Alper, Candan, Cengiz, Sever, Lale, Emre, Sevinc, Cicek, Neslihan, Akinci, Nurver, Mir, Sevgi, Poyrazoğlu, Hakan M., Tabel, Yilmaz, Mencarelli, Francesca, Burgmaier, Kathrin, Kilian, Samuel, Arbeiter, Klaus, Atmis, Bahriye, Büscher, Anja, Derichs, Ute, Dursun, Ismail, Duzova, Ali, Eid, Loai Akram, Galiano, Matthias, Gessner, Michaela, Gokce, Ibrahim, Haeffner, Karsten, Hooman, Nakysa, Jankauskiene, Augustina, Körber, Friederike, Longo, Germana, Massella, Laura, Mekahli, Djalila, Miloševski-Lomić, Gordana, Rus, Rina, Shroff, Rukshana, Stabouli, Stella, Weber, Lutz T., Wygoda, Simone, Yilmaz, Alev, Zachwieja, Katarzyna, Zagozdzon, Ilona, Dötsch, Jörg, Schaefer, Franz, Liebau, Max Christoph, Potemkina, Alexandra, Ranguelov, Nadejda, Collard, Laure, De Mul, Aurélie, Feldkoetter, Markus, Seeman, Tomas, Zieg, Jakub, Thumfart, Julia, Grundmann, Franziska, Buchholz, Björn, Pape, Lars, Gross, Oliver, Patzer, Ludwig, Schild, Raphael, Haffner, Dieter, Bernhardt, Wanja, Wuehl, Elke, Henn, Michael, Halbritter, Jan, Klaus, Günter, Lechner, Felix, Lange-Sperandio, Bärbel, Uetz, Barbara, Benz, Marcus, König, Jens, Staude, Hagen, Wurm, Donald, Bald, Martin, Soliman, Neveen A., Ariceta, Gema, Rodriguez, Juan David Gonzalez, de la Cerda Ojeda, Francisco, Harambat, Jerome, Ranchin, Bruno, Fila, Marc, Dossier, Claire, Boyer, Olivia, Marlais, Matko, UCL - (SLuc) Département de pédiatrie, Ruzgienė, Dovilė, Burgmaier, Kathrin, Kilian, Samuel, Arbeiter, Klaus, Atmis, Bahriye, Buescher, Anja, Derichs, Ute, Dursun, Ismail, Duzova, Ali, Eid, Loai Akram, Galiano, Matthias, Gessner, Michaela, Gokce, Ibrahim, Haeffner, Karsten, Hooman, Nakysa, Jankauskiene, Augustina, Koerber, Friederike, Longo, Germana, Massella, Laura, Mekahli, Djalila, Milosevski-Lomic, Gordana, Nalcacioglu, Hulya, Rus, Rina, Shroff, Rukshana, Stabouli, Stella, Weber, Lutz T., Wygoda, Simone, Yilmaz, Alev, Zachwieja, Katarzyna, Zagozdzon, Ilona, Doetsch, Joerg, Schaefer, Franz, and Liebau, Max Christoph

Subjects
Liver Cirrhosis, Male, glomerulus filtration rate, Medizin, cell surface receptor, preschool child, DISEASE, Cohort Studies, Chronic kidney disease, Polycystic kidney disease, Medicine, genetics, Longitudinal Studies, Child, pathophysiology, Ultrasonography, Kidney, Multidisciplinary, longitudinal study, organ size, chronic kidney failure, biological marker, cohort analysis, Prognosis, Autosomal Recessive Polycystic Kidney Disease, PKHD1 protein, human, Multidisciplinary Sciences, medicine.anatomical_structure, female, Quartile, Child, Preschool, Cohort, Disease Progression, Science & Technology - Other Topics, Glomerular Filtration Rate, medicine.medical_specialty, kidney, Adolescent, Science, Urology, Renal function, Kidney Volume, Receptors, Cell Surface, Article, Humans, ddc:610, human, Renal Insufficiency, Chronic, Polycystic Kidney, Autosomal Recessive, Paediatric kidney disease, Science & Technology, business.industry, echography, Infant, medicine.disease, mortality, kidney polycystic disease, disease exacerbation, physiology, business, metabolism, Biomarkers, Kidney disease
Abstract

Autosomal recessive polycystic kidney disease (ARPKD) is characterized by bilateral fibrocystic changes resulting in pronounced kidney enlargement. Impairment of kidney function is highly variable and widely available prognostic markers are urgently needed as a base for clinical decision-making and future clinical trials. In this observational study we analyzed the longitudinal development of sonographic kidney measurements in a cohort of 456 ARPKD patients from the international registry study ARegPKD. We furthermore evaluated correlations of sonomorphometric findings and functional kidney disease with the aim to describe the natural disease course and to identify potential prognostic markers. Kidney pole-to-pole (PTP) length and estimated total kidney volume (eTKV) increase with growth throughout childhood and adolescence despite individual variability. Height-adjusted PTP length decreases over time, but such a trend cannot be seen for height-adjusted eTKV (haeTKV) where we even observed a slight mean linear increase of 4.5 ml/m per year during childhood and adolescence for the overall cohort. Patients with two null PKHD1 variants had larger first documented haeTKV values than children with missense variants (median (IQR) haeTKV 793 (450–1098) ml/m in Null/null, 403 (260–538) ml/m in Null/mis, 230 (169–357) ml/m in Mis/mis). In the overall cohort, estimated glomerular filtration rate decreases with increasing haeTKV (median (IQR) haeTKV 210 (150–267) ml/m in CKD stage 1, 472 (266–880) ml/m in stage 5 without kidney replacement therapy). Strikingly, there is a clear correlation between haeTKV in the first eighteen months of life and kidney survival in childhood and adolescence with ten-year kidney survival rates ranging from 20% in patients of the highest to 94% in the lowest quartile. Early childhood haeTKV may become an easily obtainable prognostic marker of kidney disease in ARPKD, e.g. for the identification of patients for clinical studies. © 2021, The Author(s)., ESPN 2014.2; PKD Foundation, PKDF; Bundesministerium für Bildung und Forschung, BMBF: 01GM1515, 01GM1903; Universität zu Köln, UoC; Marga und Walter Boll-Stiftung; Universitätsklinikum Köln, We thank the German Society for Pediatric Nephrology (GPN), the ESCAPE Network, and the European Society for Paediatric Nephrology (ESPN; Working Groups CAKUT and Inherited Renal Diseases) for their support. ML was supported by grants of the GPN, ESPN (Grant ESPN 2014.2), and the German PKD foundation. KB and ML were supported by the Medical Faculty of the University of Cologne (Koeln Fortune program), and the Marga and Walter Boll-Foundation. FS and ML are supported by the German Federal Ministry of Research and Education (BMBF grant 01GM1515 and 01GM1903). This work was generated within the European Reference Network for Rare Kidney Disorders (ERKNet).

Published
2021

4. Hemolitik Üremik Sendrom; 10 Yıllık Tek Merkez Deneyimi

Author

PINARBAŞI, Ayşe Seda, YEL, Sibel, GÜNAY, Neslihan, POYRAZOĞLU, Hakan, GENCER BALABAN, Aynur, DURSUN, İsmail, GÜNDÜZ, Zübeyde, and DÜŞÜNSEL, Ruhan

Subjects
Hemolytic uremic syndrome,Eculizumab,Pediatrics, Hemolitik üremik sendrom,Ekulizumab,Pediatri, Medicine, Tıp
Abstract

Purpose: Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Shiga toxin producing Escherchia coli-associated HUS (STEC-HUS) is the most common cause in children. In recent years, an increase has been observed in our center in the cases of HUS, which appeared as outbreaks in different periods, and in this study, the clinical characteristics of patients with HUS were evaluated.Materials and Methods: Patients diagnosed with HUS between 2008-2018 were included in the study. The demographic characteristics of the patients, clinical findings at admission, hematological and biochemical findings at the time of admission and in the most active period of the disease, complement values, organ involvement due to HUS, applied treatments and kidney replacement treatments were evaluated.Results: Forty-three patients were included in the study. 86% of the patients had a history of diarrhea and half of these patients had diarrhea with blood. Neurological involvement was present in 30% of the patients. Eighteen patients were given eculizumab treatment. Parameters showing the progression of kidney disease such as proteinuria and hypertension were more prominent in patients who received eculizumab treatment. End-stage kidney disease developed in two patients during follow-up.Conclusion: HUS, which is an important cause of acute kidney damage, is most frequently associated with diarrhea in pediatric patients. Neurological involvement is the most common extra-renal manifestation. Kidney replacement therapy is required in most patients (70%) and eculizumab therapy is used more frequently in severe cases., Amaç: Hemolitik üremik sendrom (HÜS) mikroanjiopatik hemolitik anemi, trombositopeni ve akut böbrek hasarı ile karakterize bir tablodur. Şiga toksini üreten Escherchia coli ilişkili HÜS (STEC-HÜS) çocuklarda en sık nedendir. Farklı dönemlerde salgınlar şeklinde karşımıza çıkan HÜS vakalarında son yıllarda merkezimizde de artış görülmüştür ve bu yazımızda on yıllık HÜS ile takipli hastaların klinik özellikleri değerlendirilmiştir. Araçlar ve Yöntem: 2008-2018 yılları arasında HÜS tanısı alan hastalar çalışmaya alındı. Hastaların demografik özellikleri, başvuru klinik bulguları, başvuru anında ve hastalığın akut fazında hematolojik ve biyokimyasal bulguları, kompleman değerleri, HÜS’e bağlı organ tutulumları, uygulanan tedaviler ve böbrek yerine koyma tedavileri değerlendirildi. Bulgular: Kırk üç hasta çalışmaya alındı. Hastaların %86’sında ishal öyküsü vardı ve bu hastaların yarısında ishal kanlı idi. Nörolojik tutulum hastaların %30’unda vardı. On sekiz hastaya ekulizumab tedavisi verildi. Ekulizumab tedavisi alan hastaların proteinüri, hipertansiyon gibi böbrek hastalığının progresyonunu gösteren parametreleri daha belirgin idi. İki hastada takipte son dönem böbrek yetmezliği gelişti. Sonuç: Akut böbrek hasarının önemli bir nedeni olan HÜS çocuk hastalarda en sık ishal ilişkili olarak karşımıza çıkmaktadır. Nörolojik tutulum en sık böbrek dışı tutulum şeklidir. Hastaların çoğunda (%70) böbrek yerine koyma tedavisine gereksinim duyulmakta ve ekulizumab tedavisini progresyonu kötü olan olgularda daha sık kullanılmaktadır.

Published
2021

5. Early childhood height-adjusted total kidney volume as a risk marker of kidney survival in ARPKD

Author

UCL - (SLuc) Département de pédiatrie, Nalcacioglu, Hulya, Dunand, Oliver, Mastrangelo, Antonio, Murer, Luisa, Emma, Francesco, Ruzgiene, Dovile, Taranta-Janusz, Katarzyna, Balasz-Chmielewska, Irena, Miklaszewska, Monika, Stanczyk, Malgorzata, Sikora, Przemyslaw, Kowalewska, Claudia, Szczepanska, Maria, Teixeira, Ana, Rachisan, Andreea, Papachristou, Fotios, Paripović, Dušan, Prikhodina, Larisa, Jilani, Houweyda, Bayazit, Aysun Karabay, Soylu, Alper, Candan, Cengiz, Sever, Lale, Emre, Sevinc, Cicek, Neslihan, Akinci, Nurver, Mir, Sevgi, Poyrazoğlu, Hakan M., Tabel, Yilmaz, Mencarelli, Francesca, Burgmaier, Kathrin, Kilian, Samuel, Arbeiter, Klaus, Atmis, Bahriye, Büscher, Anja, Derichs, Ute, Dursun, Ismail, Duzova, Ali, Eid, Loai Akram, Galiano, Matthias, Gessner, Michaela, Gokce, Ibrahim, Haeffner, Karsten, Hooman, Nakysa, Jankauskiene, Augustina, Körber, Friederike, Longo, Germana, Massella, Laura, Mekahli, Djalila, Miloševski-Lomić, Gordana, Rus, Rina, Shroff, Rukshana, Stabouli, Stella, Weber, Lutz T., Wygoda, Simone, Yilmaz, Alev, Zachwieja, Katarzyna, Zagozdzon, Ilona, Dötsch, Jörg, Schaefer, Franz, Liebau, Max Christoph, Potemkina, Alexandra, Ranguelov, Nadejda, Collard, Laure, De Mul, Aurélie, Feldkoetter, Markus, Seeman, Tomas, Zieg, Jakub, Thumfart, Julia, Grundmann, Franziska, Buchholz, Björn, Pape, Lars, Gross, Oliver, Patzer, Ludwig, Schild, Raphael, Haffner, Dieter, Bernhardt, Wanja, Wuehl, Elke, Henn, Michael, Halbritter, Jan, Klaus, Günter, Lechner, Felix, Lange-Sperandio, Bärbel, Uetz, Barbara, Benz, Marcus, König, Jens, Staude, Hagen, Wurm, Donald, Bald, Martin, Soliman, Neveen A., Ariceta, Gema, Rodriguez, Juan David Gonzalez, de la Cerda Ojeda, Francisco, Harambat, Jerome, Ranchin, Bruno, Fila, Marc, Dossier, Claire, Boyer, Olivia, Marlais, Matko, UCL - (SLuc) Département de pédiatrie, Nalcacioglu, Hulya, Dunand, Oliver, Mastrangelo, Antonio, Murer, Luisa, Emma, Francesco, Ruzgiene, Dovile, Taranta-Janusz, Katarzyna, Balasz-Chmielewska, Irena, Miklaszewska, Monika, Stanczyk, Malgorzata, Sikora, Przemyslaw, Kowalewska, Claudia, Szczepanska, Maria, Teixeira, Ana, Rachisan, Andreea, Papachristou, Fotios, Paripović, Dušan, Prikhodina, Larisa, Jilani, Houweyda, Bayazit, Aysun Karabay, Soylu, Alper, Candan, Cengiz, Sever, Lale, Emre, Sevinc, Cicek, Neslihan, Akinci, Nurver, Mir, Sevgi, Poyrazoğlu, Hakan M., Tabel, Yilmaz, Mencarelli, Francesca, Burgmaier, Kathrin, Kilian, Samuel, Arbeiter, Klaus, Atmis, Bahriye, Büscher, Anja, Derichs, Ute, Dursun, Ismail, Duzova, Ali, Eid, Loai Akram, Galiano, Matthias, Gessner, Michaela, Gokce, Ibrahim, Haeffner, Karsten, Hooman, Nakysa, Jankauskiene, Augustina, Körber, Friederike, Longo, Germana, Massella, Laura, Mekahli, Djalila, Miloševski-Lomić, Gordana, Rus, Rina, Shroff, Rukshana, Stabouli, Stella, Weber, Lutz T., Wygoda, Simone, Yilmaz, Alev, Zachwieja, Katarzyna, Zagozdzon, Ilona, Dötsch, Jörg, Schaefer, Franz, Liebau, Max Christoph, Potemkina, Alexandra, Ranguelov, Nadejda, Collard, Laure, De Mul, Aurélie, Feldkoetter, Markus, Seeman, Tomas, Zieg, Jakub, Thumfart, Julia, Grundmann, Franziska, Buchholz, Björn, Pape, Lars, Gross, Oliver, Patzer, Ludwig, Schild, Raphael, Haffner, Dieter, Bernhardt, Wanja, Wuehl, Elke, Henn, Michael, Halbritter, Jan, Klaus, Günter, Lechner, Felix, Lange-Sperandio, Bärbel, Uetz, Barbara, Benz, Marcus, König, Jens, Staude, Hagen, Wurm, Donald, Bald, Martin, Soliman, Neveen A., Ariceta, Gema, Rodriguez, Juan David Gonzalez, de la Cerda Ojeda, Francisco, Harambat, Jerome, Ranchin, Bruno, Fila, Marc, Dossier, Claire, Boyer, Olivia, and Marlais, Matko

Abstract

Autosomal recessive polycystic kidney disease (ARPKD) is characterized by bilateral fibrocystic changes resulting in pronounced kidney enlargement. Impairment of kidney function is highly variable and widely available prognostic markers are urgently needed as a base for clinical decision-making and future clinical trials. In this observational study we analyzed the longitudinal development of sonographic kidney measurements in a cohort of 456 ARPKD patients from the international registry study ARegPKD. We furthermore evaluated correlations of sonomorphometric findings and functional kidney disease with the aim to describe the natural disease course and to identify potential prognostic markers. Kidney pole-to-pole (PTP) length and estimated total kidney volume (eTKV) increase with growth throughout childhood and adolescence despite individual variability. Height-adjusted PTP length decreases over time, but such a trend cannot be seen for height-adjusted eTKV (haeTKV) where we even observed a slight mean linear increase of 4.5 ml/m per year during childhood and adolescence for the overall cohort. Patients with two null PKHD1 variants had larger first documented haeTKV values than children with missense variants (median (IQR) haeTKV 793 (450–1098) ml/m in Null/null, 403 (260–538) ml/m in Null/mis, 230 (169–357) ml/m in Mis/mis). In the overall cohort, estimated glomerular filtration rate decreases with increasing haeTKV (median (IQR) haeTKV 210 (150–267) ml/m in CKD stage 1, 472 (266–880) ml/m in stage 5 without kidney replacement therapy). Strikingly, there is a clear correlation between haeTKV in the first eighteen months of life and kidney survival in childhood and adolescence with ten-year kidney survival rates ranging from 20% in patients of the highest to 94% in the lowest quartile. Early childhood haeTKV may become an easily obtainable prognostic marker of kidney disease in ARPKD, e.g. for the identification of patients for clinical studies.

Published
2021

7. AİLEVİ AKDENİZ ATEŞİ TANISINA EŞLİK EDEN HASTALIKLAR: TEK MERKEZ DENEYİMİ Diseases Accompanying Familial Mediterranean Fever: A Single-centre Experıence

Author

PAÇ KISAARSLAN, Ayşenur, ÖZDEMİR ÇİÇEK, Sümeyra, ŞAHİN, Nihal, TAŞKIN, Sema Nur, POYRAZOĞLU, Hakan, GÜNDÜZ, Zübeyde, and DÜŞÜNSEL, Ruhan

Subjects
Health Care Sciences and Services, AİLEVİ AKDENİZ ATEŞİ TANISINA EŞLİK EDEN HASTALIKLAR: TEK MERKEZ DENEYİMİ Diseases Accompanying Familial Mediterranean Fever: A Single-centre Experıence, Sağlık Bilimleri ve Hizmetleri
Abstract

ÖZETAmaç: Ailevi Akdeniz Ateşi(AAA) tekrarlayan ateş, serozit, artrit atakları ile seyreden, otoinflamatuar hastalıklarınen sık görülenidir. Klasik bulguların yanında giderek artan oranda ve çeşitlilikte eşlik eden hastalıklarberaber seyretmektedir. Çalışmamızın amacı çocuk romatoloji merkezimize başvuran AAA tanılı çocuk hastalardaeşlik eden hastalıkları incelemektir.Gereç ve Yöntem: Çalışmaya takipteki 586 AAA tanılı hastadan eşlik eden hastalığı olan 107 hasta alındı.Hasta dosyalarından yaş, AAA tanı yaşı, klinik özellikleri, eşlik eden hastalık tanı yaşları, başvuru klinik velaboratuvar özellikleri ve tedavileri kaydedildi.Bulgular: Hastaların ortalama yaşı 16 (IQR: 11,5-18) yıl, AAA tanı yaşı ise 7(IQR: 4-10) yıl olarak tespit edildi.Eşlik eden birinci hastalık ortalama tanı yaşı 10 (IQR:7-14), ikincisinin 11(IQR:7-15), üçüncüsünün 8(IQR:8-9)yıl idi. Hastalardan 96'sının (%89.71) ekson 10 mutasyonu mevcuttu. IgA vasküliti 9(%1.53), Behçet hastalığı2(%0.34), poliarteritis nodosa (PAN) 1(%0.17), kutanöz PAN 2(%0.34), ürtikeryal vaskülit 1( %0.17), oligoartikülerjüvenil idiyopatik artrit(JİA) 6(%1.02), poliartiküler JİA 3(% 0.51), EİA 37(%6.31), kronik nonenfeksiyözosteomyelit 7(%1.19), inflamatuar bağırsak hastalığı 3(%0.51), dirençli AAA 33(%5.63), amiloidoz4(%0.68), akut romatizmal ateş 3(%0.51), PFAPA 4(%0.86), çölyak hastalığı 2(%0.34), psöriasis 1(%0.17),morfea 1(%0.17), mukopolisakkaridoz tip 6 1(%0.17) hastada tespit edildi.Sonuç: AAA tanısı ile takip edilen hastaların sistemik sorgu ve muayeneleri dikkatli şekilde yapılarak atakdurumları, ilaç uyumları ve eşlik eden hastalıklar açısından değerlendirilmelidir.

Published
2020

10. Long-Term Follow-Up of Patients with a Diagnosis of Posterior Reversible Encephalopathy Syndrome.

Author

Canpolat, Mehmet, Kaya Özçora, Gül Demet, Poyrazoğlu, Hakan, Per, Huseyin, Çoşkun, Abdulhakim, Gümüş, Hakan, Arslan, Duran, Ünal, Ekrem, Karakükçü, Musa, Patıroğlu, Türkan, and Kumandaş, Sefer

Subjects
HYPERTENSION, NEUROLOGISTS, RETROSPECTIVE studies, DESCRIPTIVE statistics, POSTERIOR leukoencephalopathy syndrome, LONG-term health care
Abstract

Objective: The essential characteristics of posterior reversible encephalopathy syndrome (PRES) are the presence of acute onset neurologic symptoms, focal vasogenic edema at neuroimaging, and reversible clinical and/or radiologic findings. This study aimed to evaluate the clinical findings, causes, radiologic findings, and prognoses of patients with PRES. Methods: Patients with PRES confirmed with clinical and radiologic findings by a pediatric neurologist were evaluated retrospectively. Results: Seventeen patients with PRES were evaluated (mean age at onset, 10.23 ± 4.65 years; range, 2-17 years; girls, 29.4% [n = 5]). The mean length of follow-up was 6 ± 2.3 years (range, 3.4-10 years). Mortality due to primary disease occurred in 4 patients (23.5%) during follow-up. PRES was derived from renal diseases in 10 patients (58.8%), hematologic diseases in 6 patients (35.3%), and liver disease in one patient (5.9%). Hypertension was present in 16 patients (94.1%) at onset of PRES (>99th percentile). Seizure, the most frequent initial symptom, was observed in 82.4% (n = 14). Blurred vision and headache were the initial symptoms in 3 patients (17.6%). Sequelae were observed at magnetic resonance imaging (MRI) in 6 patients. Development of epilepsy was determined as a sequela in 4 patients (23.5%) and mental motor retardation in 2 patients (11.8%). Conclusion: Epilepsy is uncommon in patients who have recovered from PRES. The presence of gliosis on MRI and interictal epileptic discharges on electroencephalograms are major risk factors for the development of epilepsy. Antiepileptic treatment can be stopped in the early period in patients with normal MRI and electroencephalogram by eliminating the factors that trigger the seizures. [ABSTRACT FROM AUTHOR]

Published
2021
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13. Livedoid Vasculopathy with Behçet Disease

Author

Vatansever, Zehra, primary, Paç Kısaarslan, Ayşenur, additional, Sözeri, Betül, additional, Gündüz, Zübeyde, additional, Düşünsel, Ruhan, additional, Poyrazoğlu, Hakan, additional, and Deniz, Kemal, additional

Published
2016
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14. Experienced Difficulties of Children Undergoing Peritoneal Dialysis and Their Mothers: A Qualitative Study

Author

EVGİN, Derya, ERDEM, Emine, BAYAT, Meral, POYRAZOĞLU, Hakan M., and DURSUN, Jale

Subjects
Periton diyalizi uygulanan çocuklar,anneler,yaşanılan güçlükler, Children undergoing peritoneal dialysis,mothers,experienced difficulties
Abstract

Çalışma, periton diyalizi uygulanan çocukların ve annelerinin, tanı sonrasında yaşadıkları güçlükleri belirlemek amacı ile nitel bir çalışma olarak yapılmıştır. Bir üniversite hastanesinin Çocuk Nefroloji Poliklinik ve Kliniğinde periton diyalizi ile izlenen 9 yaş üstü 10 çocuk ve anneleri (n=10) örnekleme alınmıştır. Veriler, çocukların ve annelerinin tanıtıcı bilgilerini içeren anket formu, çocuklar ve annelerinin yaşadıkları güçlükleri belirlemeye yönelik hazırlanan çocuk ve anne görüşme formları kullanılarak "derinlemesine görüşme" yöntemi ile toplanmıştır. Çocukların; tanıyı ilk duyduklarında ve diyaliz tedavisine ilk başlandığında üzüntü, korku ve ağlama duyguları yaşadıkları,arkadaşlarından farklı hissettikleri, kardeşleri ile olan ilişkilerinde kıskançlık ve tartışma yaşadıkları saptanmıştır. Hastalığın beslenme, spor, sosyal ilişkiler ve okula devam etme aktivitelerini olumsuz etkilediği ve çocukların geleceğe ilişkin planlarında iyileşme ve meslek sahibi olma istekleri belirlenmiştir. Annelerin; tanıyı ilk duyduklarında ve diyaliz tedavisine başlandığında şok, üzüntü ve çaresizlik duyguları yaşadıkları, hasta çocuğun sosyal aktivitelerini kısıtladıkları ve tedaviye uyumda sorun yaşadıkları, hasta çocuğa karşı aşırı hoşgörülü ve koruyucu davrandıkları, diğer çocuklarına gösterdikleri ilgide azalma olduğu belirlenmiştir. Annelerin aile içi ilişkilerinde sorun yaşadıkları, sosyal aktivitelerinin kısıtlandığı, sosyal ilişkilerinin azaldığı, çocuğun hastalığı nedeniyle maddi konularda sıkıntı yaşadıkları saptanmıştır.Bu sonuçlar doğrultusunda, aileye ve çocuğa hastalıkla yaşam önerilmektedir, This study has been performed qualitatively to determine the difficulties experienced by children undergoing peritoneal dialysis and their mothers after diagnosis. The study sample consisted of childrenof mothers (n=10) being followed in the Pediatric Nephrology Policlinic and Clinic of University Hospital. The data was collected with in-depth interviews using the questionnaire form and the interview form to determine difficulties experienced by the children and their mothers. At the time of diagnosis and in the initiation of dialysis, children experienced sadness, fear, crying, felt different from their friends and had jealousy and arguments in their relationships with their siblings. They stated that the activities and school attendance were affected negatively by disease and had desires to recover from disease and have a profession plan for the future of the children. The mothers of children experienced shock, sadness and helplessness, restricted social activities of children with dialysis, had problem in adherence to treatment, acted extremely tolerant and protective against children with dialysis, had decreased interest in their other children. It was indicated that the mothers experienced problems relationships, restricted their social activities, reduced social relations and had financial difficulty because of the child's disease. In conclusion, adaptation programs should be organized for parents and children about living with disease

Published
2013

15. Nail Fold Capillary Abnormality and Insulin Resistance in Children with Familial Mediterranean Fever: Is There Any Relationship Between Vascular Changes and Insulin Resistance?

Author

Dursun, İsmail, Tulpar, Sebahat, Yel, Sibel, Kartal, Demet, Borlu, Murat, Baştuğ, Funda, Poyrazoğlu, Hakan, Gündüz, Zübeyde, Yüksel, Mehmet E., Köse, Kader, Çalışkan, Abdulah, Cekgeloglu, Ahmet B., and Düşünsel, Ruhan

Subjects
CAPILLARIES, INSULIN resistance, DRUG resistance, CARDIOVASCULAR diseases, TYPE 2 diabetes, DISEASES
Abstract

Objective: Nail fold capillary changes are accepted as early symptoms of several rheumatic disorders such as scleroderma and dermatomyositis. In adults, nail fold capillary abnormality (NCA) has been described in Familial Mediterranean Fever (FMF). However, there is not enough study in children with FMF. The aim of the present study was (1) to investigate whether children with FMF have NCA in both active and/or remission period or not and (2) to assess insulin resistance in children with FMF in both active and/or remission period of the disease compared with the control group. Materials and Methods: Ninety-two patients with FMF, including 25 patients in the active period and 67 patients in the remission period, and 33 apparently healthy children were enrolled in the study. Nail fold capillary examination was performed. Groups were compared for inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, and serum amyloid A (SAA)), insulin resistance (homeostatic model assessment of insulin resistance, HOMA-IR), and NCA. The relationship among the NCA, insulin resistance, and inflammatory markers was evaluated. Results: Overt NCA was found in 20% of patients at the attack period and in 2.9% of patients in remission. HOMA-IR was higher at the attack period than at the attack-free period and control. However, this did not reach statistical significance. Nevertheless, HOMA-IR was positively correlated with SAA. The NCA was significantly positively correlated with increased levels of acute-phase reactants and was significantly negatively correlated with serum high-density lipoprotein levels. Conclusion: There are apparent NCA in children with FMF especially in the active period of the disease. There is insulin resistance that is likely associated with inflammation. The NCA becomes overt in the active period of the disease as insulin resistance. [ABSTRACT FROM AUTHOR]

Published
2018
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16. Idiopathic Nephrotic Syndrome in Childhood: A Retrospective Analysis of Two Hundred and Eighty Nine Patients.

Author

Yılmaz, Kenan, Düşünsel, Ruhan, Dursun, İsmail, Yel, Sibel, Gündüz, Zübeyde, and Poyrazoğlu, Hakan

Subjects
CYCLOSPORINE, DEMOGRAPHY, DOSE-response relationship in biochemistry, DRUG resistance, MEDICAL records, NEPHROTIC syndrome, NEPHROTIC syndrome in children, STEROIDS, SYMPTOMS, MYCOPHENOLIC acid
Abstract

Copyright of Medical Bulletin of Haseki / Haseki Tip Bulteni is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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17. The diagnosis of juvenile systemic lupus erythematosus with SLICC

Author

Kısaarslan, Ayşenur Paç, primary, Sözeri, Betül, additional, Düşünsel, Ruhan, additional, Gündüz, Zübeyde, additional, Poyrazoğlu, Hakan, additional, Yel, Sibel, additional, Yılmaz, Kenan, additional, Dursun, İsmail, additional, Baştuğ, Funda, additional, and Tülpar, Sebahat, additional

Published
2014
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19. Aterosklerotik plakta chlamydia pneumoniae'nın vücuttaki lokalizasyonu

Author

Poyrazoğlu, Hakan, Yalınız, Hafize, and Göğüs Kalp ve Damar Cerrahisi Anabilim Dalı

Subjects
Göğüs Kalp ve Damar Cerrahisi, Thoracic and Cardiovascular Surgery
Abstract

ÖZET Chlamydia pnemoniae insanlarda akut solunum yolu hastalığının nedeni olan bir patojendir. Toplumda genel olarak pnomoni vakalarının %10'undan sorumlu olduğu bilinmektedir. Chlamydia' lar `eucaryotic` hücrelerin gram negatif zorunlu intraselüler bakteriyel patojenlerdir.Kültürlerinin yapılması güçtür. Dolayısıyla `Chlamydia pnemoniae` hakkında daha detaylı bilgiler serolojik araştırmalar arttıkça ortaya çıkmaktadır. Chlamydia pnemoniae ile ateroskleroz lezyonların ilişkisi günümüzde Chlamydia pnemoniae ile atereskleroz lezyonların ilişkisi herkes tarafından kabul edilmektedir. Bu çalışmada; vücuttaki değişik lokalizasyonlu aterosklerotik plaklarda Chlamdia pnemoniae varlığını araştırmak için toplam 21 hasta, 7 'şer hastadan oluşan üç grupta incelenmiştir. Grup l'de koroner bypass girişimi uygulanan 7 hasta, Grup E' de femoral aterosklerotik oklüzyonu olan 7 hasta, Grup IH' de abdominal aortada aterosklerotik oklüzyon nedeniyle öpere edilen 7 hasta bulunmaktadır. Bu üç grupta aterosklerotik plakta PCR ve serumda mikroimmünofloresan IgG ve IgA çalışılmıştır. Çalışmamızın sonucunda; aterosklerotik plakta çalışılan 21 hastanın 17' sinde (%80,95) PCR Chlamydia pnemoniae yönünden pozitif bulunmuştur. 21 hastanın 20'sinde serumda anti Chlamydia pnemoniae IgG titreleri pozitif (%95,2) ve 5 (%23,8)'inde anti Chlamydia pnemoniae IgA titreleri pozitif bulunmuştur. Chlamydia pnemoniae ile ateroskleroz arasında bir ilişkinin varlığı tespit edilmiş olup, değişik lokalizasyonlu aterosklerotik plaklarda Chlamydia pnemoniae enfeksiyonu yönünden farklılık olmadığı tespit edilmiştir. ANAHTAR KELİMELER: Aterosklerotik plak, Chlamydia pnemoniae VI ABSTRACTChlamydia pnemonia is a pathogen that causes acute respiratory tract infections. Ten percent of all community-acquired pnemonia is caused by this pathogen. Chlamydia is an obligatory eucaryotic intracellular Gr(-) bacteria, which is difficult to grow in cell culture. As serological studies evolve more detailed data is obtained about Chlamydia pnemonia. It's relation to atherosclerosis is accepted widespread.In this study 21 patients in three groups were investigated to enlighten the localisation of Chlamydia pnemonia in the atherosclerotic plaques in different sites of the body. In Group 1 the samples of coronary artery atherosclerotic plaques and blood were obtained from 7 patients undergoing coronary artery bypass operations. In group 2 the samples of femoral aortic artery atherosclerotic plaques and blood were obtained from 7 patients undergoing femoral aorta revascularisation operations. In group 3 the samples of abdominal artery atherosclerotic plaques and blood were obtained from 7 patients undergoing operations. In all three groups PCR and microimmunofloresant Ig G and Ig A were studied on the atherosclerotic plaques.PCR was found (+) for atherosclerotic plaques in 17 of 21 patients (80.95%). Anti- chlamydia pnemonia IgG titers was found positive in 20 of 21 patients (95.2%) and Ig A titers were found positive in 5 of 21 patients blood samples (24%). These results preclude that no significant difference is found between the three localisations of the atherosclerotic plaques for the three groups for Chamydia pnemonia.KEY WORDS: Atherosclerotic plaques, Chlamydia pnemoniaevn 723

Published
2002

20. Colchicine Intoxication in Children: Four Case Reports.

Author

KISAARSLAN, Ayşenur P., YEL, Sibel, YILMAZ, Kenan, AKYILDIZ, Başak Nur, DÜŞÜNSEL, Ruhan, GÜNDÜZ, Zübeyde, POYRAZOĞLU, Hakan, YÜCEL, Gül, and GÜVEN, Feride

Subjects
ACADEMIC medical centers, BLOOD testing, COLCHICINE, CASE studies, SOCIAL services case management, DESCRIPTIVE statistics, THERAPEUTICS
Abstract

Colchicine is a natural alkaloid which is derived from the colchium autumnale plant. It is used in the treatment of familial Mediterranean fever, amyloidosis, gout, Behçet's disease, and inflammatory bowel disease. In this article, we present four colchicine intoxication cases who were admitted to our clinic last year. While two patients ingested colchicine accidentally, other two took it for attempted suicide. First patient's clinical signs were gastroenteritis, fever, and alopecia. This patient developed renal, hepatic dysfunction, and rebound leucocytosis. Patient was given support treatment and discharged. Second patient's physical examination was normal except for tachycardia. Twenty hours after taking the medication, patient developed leucocytosis. The patient was performed plasmapheresis and leukapheresis. Thirty-nine hours after intake, patient developed sudden cardiac arrest and died. Third patient's clinical signs were gastroenteritis, fever, and alopecia. Patient developed hepatic dysfunction and rebound leucocytosis. Support treatment was given and patient was discharged. Last patient had no clinical sign or laboratory finding and was discharged. Doctors and other healthcare employees should be alert for possible colchicine intoxication symptoms. Early detection of overdose symptoms is significant in terms of treatment success. [ABSTRACT FROM AUTHOR]

Published
2015
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21. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two: Genoa, Italy. 28 September – 01 October 2016

Author

Lomakina, Olga, Alekseeva, Ekaterina, Valieva, Sania, Bzarova, Tatiana, Nikishina, Irina, Zholobova, Elena, Rodionovskaya, Svetlana, Kaleda, Maria, Nakagishi, Yasuo, Shimizu, Masaki, Mizuta, Mao, Yachie, Akihiro, Sugita, Yuko, Okamoto, Nami, Shabana, Kousuke, Murata, Takuji, Tamai, Hiroshi, Smith, Eve M., Yin, Peng, Jorgensen, Andrea L., Beresford, Michael W., Eleuteri, Antonio, Goilav, Beatrice, Lewandowski, Laura, Phuti, Angel, Wahezi, Dawn, Rubinstein, Tamar, Jones, Caroline, Newland, Paul, Marks, Stephen, Corkhill, Rachel, Ekdawy, Diana, Pilkington, Clarissa, Tullus, Kjell, Putterman, Chaim, Scott, Chris, Fisher, Antony C., Jorgensen, Andrea, Batu, Ezgi Deniz, Kosukcu, Can, Taskiran, Ekim, Akman, Sema, Ozturk, Kubra, Sozeri, Betul, Unsal, Erbil, Ekinci, Zelal, Bilginer, Yelda, Alikasifoglu, Mehmet, Ozen, Seza, Lythgoe, Hanna, Brunner, Hermine I., Gulati, Gaurav, Jones, Jordan T., Altaye, Mekibib, Eaton, Jamie, Difrancesco, Mark, Yeo, Joo Guan, Leong, Jingyao, Bathi, Loshinidevi D/O Thana, Arkachaisri, Thaschawee, Albani, Salvatore, Abdelrahman, Nagla, Beresford, Michael W, Leone, Valentina, Groot, Noortje, Shaikhani, D., Bultink, I. E. M., Bijl, M., Dolhain, R. J. E. M., Teng, Y. K. O., Zirkzee, E., de Leeuw, K., Fritsch-Stork, R., Kamphuis, S. S. M., Wright, Rachael D., Abdawani, Reem, Al Shaqshi, Laila, Al Zakwani, Ibrahim, Gormezano, Natali W., Kern, David, Pereira, Oriany L., Esteves, Gladys C. C., Sallum, Adriana M., Aikawa, Nadia E., Pereira, Rosa M., Silva, Clovis A., Bonfa, Eloisa, Beckmann, Jessica, Bartholomä, Nora, Venhoff, Nils, Henneke, Philipp, Salzer, Ulrich, Janda, Ales, Boteanu, Alina Lucica, Corral, Sandra Garrote, Giraldo, Alberto Sifuentes, Gámir, Mariluz Gámir, Mendoza, Antonio Zea, Adrovic, Amra, Dedeoglu, Reyhan, Sahin, Sezgin, Barut, Kenan, Koka, Aida, Oztunc, Funda, Kasapcopur, Ozgur, Rodriguez-Lozano, Ana Luisa, Rivas-Larrauri, Francisco, de la Puente, Silvestre García, Alves, Andressa G. F., Giacomin, Maria F. D. A., Farhat, Juliana, Braga, Alfésio L. F., Sallum, Adriana M. E., Campos, Lúcia M. D. A., Pereira, Luiz A. A., Lichtenfels, Ana J. D. F. C., Silva, Clóvis A., Farhat, Sylvia C. L., Acar, Banu, Ozcakar, Z. Birsin, Çakar, Nilgün, Uncu, Nermin, Gür, Gökçe, Özdel, Semanur, Yalçınkaya, Fatoş, Scott, Christiaan, Brice, Nicky, Nourse, Peter, Arango, Christine, Mosquera, Angela C., Malagon, Clara, Sakamoto, Ana P., Silva, Marco F. C. D., Lopes, Ananadreia S., Russo, Gleice C. S., Sallum, Adriana E. M., Kozu, Katia, Bonfá, Eloisa, Saad-Magalhães, Claudia, Pereira, Rosa M. R., Len, Claudio A., Terreri, Maria T., Suri, Deepti, Didel, Siyaram, Rawat, Amit, Singh, Surjit, Maritsi, Despoina, Onoufriou, MArgarita, Vougiouka, Olga, Tsolia, Maria, Bosak, Edi Paleka, Vidović, Mandica, Lamot, Mirta, Lamot, Lovro, Harjaček, Miroslav, Van Nieuwenhove, Erika, Liston, Adrian, Wouters, Carine, Tahghighi, Fatemeh, Ziaee, Vahid, Raeeskarami, Seid-Reza, Aguiar, Francisca, Pereira, Sandra, Rodrigues, Mariana, Moura, Cláudia, Rocha, Gustavo, Guimarães, Hercília, Brito, Iva, Fonseca, Rita, Horneff, Gerd, Klein, Ariane, Minden, Kirsten, Huppertz, Hans-Iko, Weller-Heinemann, Frank, Kuemmerle-Deschner, Jasmin, Haas, J-Peter, Hospach, Anton, Menendez-Castro, Ricardo, Huegle, Boris, Haas, Johannes-Peter, Swart, Joost, Giancane, Gabriella, Bovis, Francesca, Castagnola, Elio, Groll, Andreas, Lovell, Daniel J., Wolfs, Tom, Hofer, Michael, Panaviene, Violeta, Nielsen, Susan, Anton, Jordi, Uettwiller, Florence, Stanevicha, Valda, Trachana, Maria, Marafon, Denise Pires, Ailioaie, Constantin, Tsitsami, Elena, Kamphuis, Sylvia, Herlin, Troels, Doležalová, Pavla, Susic, Gordana, Flatø, Berit, Sztajnbok, Flavio, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Gattorno, Marco, Brucato, Antonio, Finetti, Martina, Lazaros, George, Maestroni, Silvia, Carraro, Mara, Cumetti, Davide, Carobbio, Alessandra, Lorini, Monia, Rimini, Alessandro, Marcolongo, Renzo, Valenti, Anna, Erre, Gian Luca, Belli, Riccardo, Gaita, Fiorenzo, Sormani, Maria Pia, Imazio, Massimo, Abinun, Mario, Smith, Nicola, Rapley, Tim, McErlane, Flora, Kearsley-Fleet, Lianne, Hyrich, Kimme L., Foster, Helen, Tzaribachev, Nikolay, Zeft, Andrew, Cimaz, Rolando, Bohnsack, John, Griffin, Thomas, Carrasco, Ruy, Dare, Jason, Foeldvari, Ivan, Vehe, Richard, Simon, Teresa, Brunner, Hermine, Verazza, S., Davì, S., Consolaro, A., Insalaco, A., Gerloni, V., Cimaz, R., Zulian, F., Pastore, S., Corona, F., Conti, G., Barone, P., Cattalini, M., Cortis, E., Breda, L., Olivieri, A. N., Civino, A., Podda, R., Rigante, D., La Torre, F., D’Angelo, G., Jorini, M., Gallizzi, R., Maggio, M. C., Consolini, R., De Fanti, A., Alpigiani, M. G., Martini, A., Ravelli, A., Kısaarslan, Aysenur Pac, Gunduz, Zubeyde, Dusunsel, Ruhan, Dursun, Ismail, Poyrazoglu, Hakan, Kuchinskaya, Ekaterina, Abduragimova, Farida, Kostik, Mikhail, Sundberg, Erik, Omarsdottir, Soley, Klevenvall, Lena, Erlandsson-Harris, Helena, Basbozkurt, Gokalp, Erdemli, Ozge, Simsek, Dogan, Yazici, Fatih, Karsioglu, Yildirim, Tezcaner, Aysen, Keskin, Dilek, Ozkan, Huseyin, Acikel, Cengizhan, Demirkaya, Erkan, Orbán, Ilonka, Sevcic, Krisztina, Brodszky, Valentin, Kiss, Emese, Tekko, Ismaiel A., Rooney, Madeleine, McElnay, James, Taggart, Cliff, McCarthy, Helen, Donnelly, Ryan F., Slatter, Mary, Nademi, Zohreh, Friswell, Mark, Jandial, Sharmila, Flood, Terence, Hambleton, Sophie, Gennery, Andrew, Cant, Andrew, Duong, Phoi-Ngoc, Koné-Paut, Isabelle, Filocamo, Giovanni, Gamir, María Luz, Sanner, Helga, Carenini, Laura, Topdemir, Mesut, Karslioglu, Yildirim, Gok, Faysal, Tsurikova, Nadezhda, Ligostaeva, Elena, Ramchurn, Navdha R., Kostareva, O., Nikishina, I., Arsenyeva, S., Rodionovskaya, S., Kaleda, M., Alexeev, D., Dursun, Ismail Dursun, Murias, Sara, Barral, Estefania, Alcobendas, Rosa, Enriquez, Eugenia, Remesal, Agustin, de Inocencio, Jaime, Castro, Tania M., Lotufo, Simone A., Freye, Tatjana, Carlomagno, Raffaella, Zumbrunn, Thomas, Bonhoeffer, Jan, Schneider, Elvira Cannizzaro, Kaiser, Daniela, Hofer, Michaël, Hentgen, Véronique, Woerner, Andreas, Schwarz, Tobias, Klotsche, Jens, Niewerth, Martina, Ganser, Gerd, Jeyaratnam, Jerold, ter Haar, Nienke, Rigante, Donato, Dedeoglu, Fatma, Baris, Ezgi, Vastert, Sebastiaan, Frenkel, Joost, Hausmann, Jonathan S., Lomax, Kathleen G., Shapiro, Ari, Durrant, Karen L., Brogan, P. A., Hofer, M., Kuemmerle-Deschner, J. B., Lauwerys, B., Speziale, A., Leon, K., Wei, X., Laxer, R. M., Signa, Sara, Rusmini, Marta, Campione, Elena, Chiesa, Sabrina, Grossi, Alice, Omenetti, Alessia, Caorsi, Roberta, Viglizzo, Gianmaria, Ceccherini, Isabella, Federici, Silvia, Lachmann, Helen, Ruperto, Nicola, Vanoni, Federica, Gomes, Sonia Melo, Omoyinmi, Ebun, Arostegui, Juan I., Gonzalez-Roca, Eva, Eleftheriou, Despina, Klein, Nigel, Brogan, Paul, Volpi, Stefano, Santori, Elettra, Picco, Paolo, Pastorino, Claudia, Rice, Gillian, Tesser, Alessandra, Crow, Yanick, Candotti, Fabio, Sinoplu, Ada B., Yucel, Gozde, Pamuk, Gizem, Damian, Laura O., Lazea, Cecilia, Sparchez, Mihaela, Vele, Paulina, Muntean, Laura, Albu, Adriana, Rednic, Simona, Lazar, Calin, Mendonça, Leonardo O., Pontillo, Alessandra, Kalil, Jorge, Castro, Fabio M., Barros, Myrthes T., Pardeo, Manuela, Messia, Virginia, De Benedetti, Fabrizio, Insalaco, Antonella, Malighetti, Giorgia, Gorio, Chiara, Ricci, Francesca, Parissenti, Ilaria, Montesano, Paola, Bonafini, Barbara, Medeghini, Veronica, Cattalini, Marco, Giordano, Lucio, Zani, Giulia, Ferraro, Rosalba, Vairo, Donatella, Giliani, Silvia, Maggio, Maria Cristina, Luppino, Girolamo, Corsello, Giovanni, Fernandez, Maria Isabel Gonzalez, Montesinos, Berta Lopez, Vidal, Adriana Rodriguez, Gorospe, Juan I. Arostegui, Penades, Inmaculada Calvo, Rafiq, Nadia K., Wynne, Karen, Hussain, Khalid, Brogan, Paul A., Ang, Elizabeth, Ng, Nicholas, Kacar, Ayla, Gucenmez, Ozge Altug, Makay, Balahan, Unsal, Sevket Erbil, Sahin, Yasin, Kutlu, Tufan, Cullu-Cokugras, Fugen, Ayyildiz-Civan, Hasret, Erkan, Tulay, Al Zuhbi, Sana, Abdalla, Eiman, Russo, Ricardo A., Katsicas, María M., Minoia, Francesca, Ravelli, Angelo, Bhattad, Sagar, Gupta, Anju, Pandiarajan, Vignesh, Nada, Ritambhra, Tiewsoh, Kaara, Hawkins, Philip, Rowczenio, Dorota, Fingerhutova, Sarka, Franova, Jana, Prochazkova, Leona, Hlavackova, Eva, Dolezalova, Pavla, Evrengül, Havva, Yüksel, Selçuk, Doğan, Mustafa, Gürses, Dolunay, Evrengül, Harun, De Pauli, Silvia, Pastore, Serena, Bianco, Anna Monica, Severini, Giovanni Maria, Taddio, Andrea, Tommasini, Alberto, Salugina, Svetlana O., Fedorov, Evgeny, Kamenets, Elena, Zaharova, Ekaterina, Sleptsova, Tatiana, Alexeeva, Ekaterina, Savostyanov, Kirill, Pushkov, Alexander, Bzarova, Tatyana, Valieva, Saniya, Denisova, Rina, Isayeva, Kseniya, Chistyakova, Evgeniya, Soloshenko, Margarita, Kaschenko, Elena, Kaneko, Utako, Imai, Chihaya, Saitoh, Akihiko, Teixeira, Vitor A., Ramos, Filipa O., Costa, Manuela, Aviel, Yonatan Butbul, Fahoum, Shafe, Brik, Riva, Özçakar, Zeynep Birsin, Celikel, Banu Acar, Yalcinkaya, Fatos, Schiappapietra, Benedetta, Davi’, Sergio, Mongini, Federica, Giannone, Luisa, Bava, Cecilia, Alpigiani, Maria Giannina, Consolaro, Alessandro, Lazarevic, Dragana S., Vojinovic, Jelena, Basic, Jelena, Muratore, Valentina, Marzetti, Valentina, Quilis, Neus, Benavente, Belen Serrano, Alongi, Alessandra, Civino, Adele, Quartulli, Lorenzo, Januskeviciute, Giedre, van Dijkhuizen, Pieter, Groot, N., van Dijk, W., Kardolus, A., Suárez, Raul Gutiérrez, Nordal, Ellen B., Rypdal, Veronika G., Berntson, Lillemor, Ekelund, Maria, Aalto, Kristiina, Peltoniemi, Suvi, Zak, Marek, Glerup, Mia, Arnstad, Ellen D., Fasth, Anders, Rygg, Marite, Duarte, Ana Catarina, Sousa, Sandra, Teixeira, Lídia, Cordeiro, Ana, Santos, Mª José, Mourão, Ana Filipa, Santos, Maria José, Eusébio, Mónica, Lopes, Ana, Oliveira-Ramos, Filipa, Salgado, Manuel, Estanqueiro, Paula, Melo-Gomes, José, Martins, Fernando, Costa, José, Furtado, Carolina, Figueira, Ricardo, Branco, Jaime C., Fonseca, João E., Canhão, Helena, Mourão, Ana F., Santos, Maria Jose, Coda, Andrea, Cassidy, Samuel, West, Kerry, Hendry, Gordon, Grech, Debra, Jones, Julie, Hawke, Fiona, Grewal, Davinder Singh, Foley, Charlene, Killeen, Orla, MacDermott, Emma, Veale, Douglas, Fearon, Ursula, Konukbay, Dilek, Tarakci, Ela, Arman, Nilay, Şahin, Sezgin, Munro, Jane, Morgan, Esi, Riebschleger, Meredith, Horonjeff, Jennifer, Strand, Vibeke, Bingham, Clifton, Collante, Ma. Theresa M., Ganeva, Margarita, Stefanov, Stefan, Telcharova, Albena, Mihaylova, Dimitrina, Saraeva, Radoslava, Tzveova, Reni, Kaneva, Radka, Tsakova, Adelina, Temelkova, Katya, Picarelli, Maria Mercedes C., Danzmann, Luiz C., Barbé-Tuana, Florencia, Grun, Lucas K., Jones, Marcus H., Frković, Marijan, Ištuk, Karla, Birkić, Ika, Sršen, Saša, Jelušić, Marija, Easton, Alan, Quarmby, Rachael, Khubchandani, Raju, Chan, Mercedes, Srp, Radoslav, Kobrova, Katerina, Nemcova, Dana, Hoza, Jozef, Uher, Michal, Saifridova, Melania, Linkova, Lenka, Charuvanij, Sirirat, Leelayuwattanakul, Isree, Pacharapakornpong, Thita, Vallipakorn, Sakda A.-O., Lerkvaleekul, Butsabong, Vilaiyuk, Soamarat, Lanni, Stefano, Davì, Sergio, Cron, Randy Q., Passarelli, Chiara, Pisaneschi, Elisa, Novelli, Antonio, Bracaglia, Claudia, Caiello, Ivan, de Graaf, Kathy, Guilhot, Florence, Ferlin, Walter, Schulert, Grant, Grom, Alexi A., Nelson, Robert, de Min, Cristina, Holzinger, Dirk, Kessel, Christoph, Fall, Ndate, Grom, Alexei, de Jager, Wilco, Strippoli, Raffaele, Horne, Anna, Ehl, Stephan, Ammann, Sandra, Lehmberg, Kai, Beutel, Karin, Foell, Dirk, Horne, AnnaCarin, Pagani, Laura, Espada, Graciela, Gao, Yi-jin, Shenoi, Susan, Weitzman, Sheila, Prencipe, Giusi, Pascarella, Antonia, Ferlin, Walter G., Chatel, Laurence, Jacqmin, Philippe, De Graaf, Kathy, Ballabio, Maria, Johnson, Zoë, Lapeyre, Geneviève, de Benedetti, Fabrizio, Cristina, de Min, Wakiguchi, Hiroyuki, Hasegawa, Shunji, Hirano, Reiji, Okazaki, Fumiko, Nakamura, Tamaki, Kaneyasu, Hidenobu, Ohga, Shouichi, Yamazaki, Kazuko, Nozawa, Tomo, Kanetaka, Taichi, Ito, Shuichi, Yokota, Shumpei, McLellan, Kirsty, MacGregor, Ishbel, Martin, Neil, Davidson, Joyce, Hansmann, Sandra, Eikelberg, Andreas, Haug, Iris, Schuller, Sabrina, Benseler, Susanne M., Nazarova, Liliia S., Danilko, Kseniia V., Malievsky, Viktor A., Viktorova, Tatiana V., Mauro, Angela, Barnicoat, Angela, Hurst, Jane, Canham, Nathalie, Lacassagne, Sandrine, Wiener, Anastasia, Hügle, Boris, Denecke, Bernd, Costa-Filho, Ivan, Haas, Johannes Peter, Tenbrock, Klaus, Popp, David, Boltjes, Arjan, Rühle, Frank, Herresthal, Stefanie, van Wijk, Femke, Schultze, Joachim, Stoll, Monika, Klotz, Luisa, Vogl, Thomas, Roth, Johannes, Quesada-Masachs, Estefania, de la Sierra, Daniel Álvarez, Prat, Marina Garcia, Sánchez, Ana M. Marín, Borrell, Ricardo Pujol, Barril, Sara Marsal, Gallo, Mónica Martínez, Caballero, Consuelo Modesto, Chyzheuskaya, Iryna, Byelyaeva, Lyudmyla M., Filonovich, Rostislav M., Khrustaleva, Helena K., Zajtseva, Larisa I., Yuraga, Tamara M., Giner, Thomas, Hackl, Lukas, Albrecht, Julia, Würzner, Reinhard, Brunner, Juergen, Minute, Marta, Parentin, Fulvio, Nocerino, Agostino, Nørgaard, Mette, Alberdi-Saugstrup, Mikel, Zak, Marek S., Nielsen, Susan M., Nordal, Ellen, Müller, Klaus G., Avramovič, Mojca Zajc, Dolžan, Vita, Toplak, Nataša, Avčin, Tadej, Ruperto, N., Lovell, D. J., Wallace, C., Toth, M., Foeldvari, I., Bohnsack, J., Milojevic, D., Rabinovich, C., Kingsbury, D., Marzan, K., Quartier, P., Minden, K., Chalom, E., Horneff, G., Kuester, R. M., Dare, J., Heinrich, M., Kupper, H., Kalabic, J., Brunner, H. I., Burgos-Vargas, Ruben, Constantin, Tamas, Dehoorne, Joke, Stanevica, Valda, Kobusinska, Katarzyna, Zuber, Zbigniew, Mouy, Richard, Rumba-Rozenfelde, Ingrida, Job-Deslandre, Chantal, Pederson, Ronald, Bukowski, Jack, Hinnershitz, Tina, Vlahos, Bonnie, Keskitalo, Paula, Kangas, Salla, Vähäsalo, Paula, Valencia, Raul A. Chavez, Martino, David, Ponsonby, Anne-Louise, Chiaroni-Clarke, Rachel, Meyer, Braydon, Allen, Roger C., Akikusa, Jonathan D., Craig, Jeffrey M., Saffrey, Richard, Ellis, Justine A., Wallace, Carol, Uziel, Yosef, Sterba, Gary, Schneider, Rayfel, Russo, Ricardo, Ramanan, Athimalaipet V., Schmid, Jana Pachlopnik, Nichols, Kim E, Miettunen, Paivi, Kitoh, Toshiyuki, Ilowite, Norman T., Henter, Jan-Inge, Grom, Alexei A, Behrens, Edward M., Avcin, Tadej, Aricò, Maurizio, Grevich, Sriharsha, Lee, Peggy, Ringold, Sarah, Leroux, Brian, Leahey, Hannah, Yuasa, Megan, Foster, Jessica, Sokolove, Jeremy, Lahey, Lauren, Robinson, William, Newson, Joshua, Stevens, Anne, Shoop, Stephanie J. W., Verstappen, Suzanne M. M., Thomson, Wendy, McDonagh, Janet E., Beukelman, Timothy, Kimura, Yuki, Natter, Marc, Ilowite, Norm, Mieszkalski, Kelly, Burrell, Grendel, Best, Brian, Bristow, Helen, Carr, Shannon, Dennos, Anne, Kaufmann, Rachel, Schanberg, Laura, Simonini, Gabriele, Lancini, Francesca, Gerbaux, Margaux, Lê, Phu-Quoc, Goffin, Laurence, Badot, Valérie, La, Céline, Caspers, Laure, Willermain, François, Ferster, Alina, Ceci, Maria, Licciardi, Francesco, Turco, Marco, Santarelli, Francesca, Montin, Davide, Toppino, Claudia, Alizzi, Clotilde, Papia, Bruno, Vergara, Beatrice, Corpora, Umberto, Messina, Luca, Tsinti, Maria, Dermentzoglou, Vasiliko, Tziavas, Panagiotis, Perica, Marija, Bukovac, Lana Tambić, Çakan, Mustafa, Ayaz, Nuray Aktay, Keskindemirci, Gonca, Lang, Michael, Laing, Catherine, Benseler, Susanne, Gerschman, Tommy, Luca, Nadia, Schmeling, Heinrike, Dropol, Anastasia, Taiani, Jaymi, Johnson, Nicole, Rusted, Brian, Nalbanti, Panagiota, Pratsidou, Polyxeni, Pardalos, Grigoris, Tzimouli, Vasiliki, Taparkou, Anna, Stavrakidou, Maria, Papachristou, Fotios, Kanakoudi-Tsakalidou, Florence, Bale, Peter, Robinson, Emily, Palman, Jason, Ralph, Elizabeth, Gilmour, Kimberly, Heard, Clare, Wedderburn, Lucy R., Barrense-Dias, Yara, Gregory, Antonarakis, Amira, Dhouib, Paolo, Scolozzi, Sylviane, Hanquinet, Michaël, Hofer, Panko, Nataliya, Shokry, Salah, Rakovska, Liudmila, Pino, Sally, Diaz-Maldonado, Adriana, Guarnizo, Pilar, Torreggiani, Sofia, Cressoni, Paolo, Garagiola, Umberto, Di Landro, Giancarla, Farronato, Giampietro, Corona, Fabrizia, Bell, Samantha, Bhatti, Parveen, Nelson, Lee, Mueller, Beth A., Simon, T. A., Baheti, A., Ray, N., Guo, Z., Hazra, Anasuya, Stock, Thomas, Wang, Ronnie, Mebus, Charles, Alvey, Christine, Lamba, Manisha, Krishnaswami, Sriram, Conte, Umberto, Wang, Min, Kingsbury, Daniel, Koskova, Elena, Smolewska, Elzbieta, Vehe, Richard K., Lovell, Daniel, Kubota, Tomohiro, Yasumura, Junko, Kizawa, Toshitaka, Yashiro, Masato, Yamatou, Tsuyoshi, Yamasaki, Yuichi, Takei, Syuji, Kawano, Yoshifumi, Nykvist, Ulrika Järpemo, Magnusson, Bo, Wicksell, Rikard, Palmblad, Karin, Olsson, Gunnar L., Modaressi, Mohammadreza, Moradinejad, Mohammad-Hassan, Seraya, Valentina, Vitebskaya, Alisa, Moshe, Veronica, Amarilyo, Gil, Harel, Liora, Hashkes, Phillip J, Mendelson, Amir, Rabinowicz, Noa, Reis, Yonit, Dāvidsone, Zane, Lazareva, Arina, Šantere, Ruta, Bērziņa, Dace, Staņēviča, Valda, Varnier, Giulia Camilla, Maillard, Susan, Ferrari, Cristina, Zaffarano, Silvia, Wienke, Judith, Enders, Felicitas Bellutti, van den Hoogen, Lucas L., Mertens, Jorre S., Radstake, Timothy R., Hotten, Henny G., Fritsch, Ruth, Wedderburn, Lucy, Nistala, Kiran, Prakken, Berent, van Royen-Kerkhof, Annet, Alhemairi, Mohammad, Muzaffer, Mohammed, Van Dijkhuizen, Pieter, Deakin, Claire T., Simou, Stefania, De Iorio, Maria, Wu, Qiong, Amin, Tania, Dossetter, Lee, Campanilho-Marques, Raquel, Deakin, Claire, Pilkington, Clarissa A., Rosina, Silvia, Soponkanaporn, Sirisucha, Arıcı, Zehra S., Tuğcu, Gökçen D., Batu, Ezgi D., Sönmez, Hafize E., Doğru-Ersöz, Deniz, Talim, Beril, Kiper, Nural, Özen, Seza, Solyom, Alexander, Batu, Ezgi, Mitchell, John, Kariminejad, Ariana, Hadipour, Fatemeh, Hadipour, Zahra, Torcoletti, Marta, Agostoni, Carlo, Di Rocco, Maja, Tanpaiboon, Pranoot, Superti-Furga, Andrea, Bonafé, Luisa, Arslan, Nur, Guelbert, Norberto, Ehlert, Karoline, Grigelioniene, Giedre, Puri, Ratna, Schuchman, Edward, Gomez, Pilar, Gonzalez, Tatiana, Yepez, Ricardo, Vargas, Camilo, Fernanda, Falcini, Lepri, Gemma, Ferrari, Alessandra, Matucci-Cerinic, Marco, Meini, Antonella, Moneta, Gian Marco, Marasco, Emiliano, Nicolai, Rebecca, Bracci-Laudiero, Luisa, Kopchak, Olga, Mushkin, Alexander, Maletin, Alexey, Mosquera, Catalina, Amorim, Rita A., Molina, Juliana, Moreira, Gustavo, Santos, Flávia H., Fraga, Melissa, Keppeke, Livia, Silva, Vanessa M., Hirotsu, Camila, Tufik, Sergio, Terreri, Maria Teresa, Braga, Vinícius L., Fonseca, Maria Beatriz, Schinzel, Vania, Terreri, Maria Teresa R., Jorge, Liliana, Guerra, Liana, Junior, Edson Amaro, Castiglione, Maria Cristina, Tricarico, Alessandra, Boulter, Emily, Schultz, Andre, Murray, Kevin, Falcini, Fernanda, Stagi, Stefano, Bellucci, Eleonora, Grein, Ingrid H. R., Pileggi, Gecilmara, Pinto, Natália B. F., de Oliveira, Aline L., Belyaeva, Lyudmila, Filonovich, Rostislav, Khrustaleva, Helena, Zajtseva, Larisa, Ilisson, Jaanika, Pruunsild, Chris, Gilliaux, Olivier, Corazza, Francis, Lelubre, Christophe, Morel, Zoilo, C, Claudia Saad-Magalhães, Lira, Luis, Ladino, Mabel, Eraso, Ruth, Arroyo, Ivonne, Silva, Clovis, and Rose, Carlos

Published
2017
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22. Jüvenil idiyopatik artritli hastalarda sekel durumunun değerlendirilmesi.

Author

Asadova, Sevda, Kısaarslan, Ayşenur Paç, Çiçek, Sümeyra Özdemir, Şahin, Nihal, Taşkın, Sema Nur, Doğantan, Şeyda, and Poyrazoğlu, Hakan

Abstract

Copyright of Journal of Turkish Society for Rheumatology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021

23. Mid-term results of patients following total surgical correction of tetralogy of Fallot.

Author

Erdem, Sevcan, Özbarlas, Nazan, Küçükosmanoğlu, Osman, Poyrazoğlu, Hakan, and Salih, Orhan Kemal

Abstract

The aim of this study was to evaluate the mid-term clinical status of patients following tetralogy of Fallot (TOF) repair. We performed a cross-sectional observational analysis of 57 postoperative TOF patients and 58 age-matched controls. Patients were examined with myocardial performance index (MPI), which was obtained by tissue Doppler imaging (TDI) in addition to the conventional methods. Compared with controls, patients had significantly higher right ventricular (RV) dimensions and volumes, RV MPI and left ventricular (LV) MPI, and significantly lower RV ejection fraction (EF), LV EF, exercise duration, and maximum heart rate with exercise (p<0.001 for all parameters). A positive correlation was found between RV MPI and LV MPI (r=0.541, p<0.001). There was a negative correlation between LV MPI and exercise duration (r=0.260, p=0.034). After total surgical correction of TOF, the patients had a good clinical status at the mid-term follow-up; decreased exercise capacity and impaired functions in both ventricles related to the degree of pulmonary regurgitation were found. By using MPI, impaired cardiac functions can identify such conditions before they become clinically symptomatic. [ABSTRACT FROM AUTHOR]

Published
2012

24. Behçet Hastalığı ile Birlikte Görülen Livedoid Vaskülopati.

Author

Vatansever, Zehra, Paç Kısaarslan, Ayşenur, Sözeri, Betül, Gündüz, Zübeyde, Düşünsel, Ruhan, Poyrazoğlu, Hakan, and Deniz, Kemal

Abstract

Copyright of Journal of Pediatric Research is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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25. Spider poisoning: a report of six cases from the Central Anatolian region, Turkey.

Author

Akyıldız, Başak, Kurtoğlu, Selim, Poyrazoğlu, Hakan, and Özcan, Ahmet

Abstract

Spiders exist in every place and ecosystem. Spiders in tropical regions are particularly poisonous and can be dangerous to humans. Nearly 20,000 spider species are known, and almost all are venomous, although only 60 species worldwide are poisonous in humans. In our area, eight species are reported as poisonous in humans. Although most cases of spider bite are benign and require no intervention, severe local and systemic reactions may occur sometimes in the pediatric population, resulting in admission to the pediatric intensive care unit. In this report, we present the cases of six children from the Central Anatolian region in Turkey who were seriously affected by spider bites, and we review the literature on spider envenomation. [ABSTRACT FROM AUTHOR]

Published
2009

31. Urinary System Infection Caused by Paecilomyces Variotti.

Author

Çolakoglu, Selcan, Durmaz, Süleyman, Poyrazoğlu, Hakan, Tekinsen, F. Filiz Kasap, Altay Atalay, M., and Koc, A. Nedret

Abstract

Fungal organisms are one of the important factor in nosocomial urinary tract infections caused by endourological procedures. Herein we report a case of pyelonephritis caused by Paecilomyces variotti in a 14-month-old child following an uriner tract operation. He had operation in 3.5-month-old for reason of ureteropelvic junction obstruction. Approximately two months after the operation a tissue fragments ejected from urinary tract. The patient admitted to our hospital because of bimonthly recurrence was occured. This tissue fragment was sent for fungal studies to our department. Direct microscopy revealed hyphae. P. variotii was isolated from discarded tissue fragments. Cure was achieved by 2 mg / kg / day for 15 days treatment with amphotericin B. [ABSTRACT FROM AUTHOR]

Published
2016
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32. Juvenil idiyopatik artritli hastalarda oksidatif stres değişkenlerinin değerlendirilmesi ve klinik bulgular arasındaki ilişkisi

Author

Gökçek, İkbal, Poyrazoğlu, Hakan, and Çocuk Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
Arteritis, Oxidative stress, Joint diseases, Children, Antioxidants, Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
Abstract

Amaç: Juvenil idiyopatik artrit (JİA), kronik inflamasyonla giden, tedavi edilmediğinde ya da yetersiz tedavi edildiğinde eklemlerde harabiyet sonucu yaşam kalitesinin olumsuz etkilendiği, çocukluk çağı inflamatuar hastalıklarındandır. Patogenezi henüz tam bilinmemekle beraber, herhangi bir nedenle başlayan nötrofil aktivasyonu sonucu eklemlerde tetiklenen inflamasyon, açığa çıkan serbest oksijen radikalleri ve yetersiz kalan antioksidan sistemin hastalığın kronikleşmesinde rol oynayabileceği düşünülmektedir.Bu çalışmada hastalıktaki mevcut inflamasyonla oksidan-antioksidan sistemler arasındaki ilişkinin belirlenmesi amaçlandı.Gereç ve Yöntem: Bu çalışmaya Eylül 2009 ile Aralık 2009 tarihleri arasında, Erciyes Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Romatoloji Polikliniğine başvuran JİA tanısı almış 45 hasta alındı. Bu hastalar fizik muayene yapıldıktan ve almakta oldukları tedaviler açısından sorgulandıktan sonra, hastalardan tam kan sayımı, karaciğer ve böbrek fonksiyon testleri, eritrosit sedimentasyon hızı, CRP, AOPP, MPO, tiyol, TOK, TAOK ve neopterin düzeyleri çalışılmak üzere kan örnekleri alındı.Bulgular: Çalışmaya 45 hasta alındı. Hastaların ortalama yaşı 9.6 yıl idi. Kız/erkek oranı 1.5 (K/E=27/18) idi. Hastaların 21'ine oligoartiküler JİA, 17'sine poliartiküler JİA ve yedisine sistemik JİA tanısı konulmuş olup, çalışma sırasında 23 hasta aktivasyon, 22 hasta ise remisyon dönemindeydi. Ortalama hastalık süresi 2.2 yıl idi.Aktivasyon dönemindeki hastalarda serum ESH, CRP, TOK, TAOK, MPO düzeyleri remisyon dönemindeki hastalardan yüksek bulundu (p

Published
2010

33. Doğum öncesi hidronefroz tanısı konulan çocuklarda bir yıllık izlem sonuçları ve renal fonksiyonların değerlendirilmesi

Author

Yel, Sibel, Poyrazoğlu, Hakan, and Çocuk Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
Abstract

Giris ve amaç: Ultrasonografinin yaygın kullanımı ile doğum öncesidönemde tespit edilebilen en sık ürolojik anomali hidronefrozdur. Obstruktif üropatiuzun dönemde renal hasar ile renal fonksiyon kaybına ve renal replasman tedavigereksinimine yol açarak ciddi morbidite ve mortalite nedeni olmaktadır.Çalısmamızda doğum öncesi hidronefroz sebepleri ve sıklığını ortaya koymayı, biryıl sonunda hastaların son durumlarını değerlendirmeyi, çalısma sonundaki böbrekfonksiyonları ile baslangıç parametreleri arasında bir iliski varlığını arastırmayı vemuhtemel prognostik faktörleri belirlemeyi amaçladık.Hastalar ve metod: Nisan 2006 ve Ekim 2007 tarihleri arasında doğan vedoğum öncesi dönemde kadın-doğum uzmanı tarafından yapılan fetal USG'dehidronefroz tespit edilerek fakültemiz pediatri nefroloji polkliniğine basvurantoplam 48 bebek doğumdan sonra izlem programına alındı. Doğumdan sonra 72 saat-7. gün, 4-6. hafta, 3.ay, 6.ay ve 12. aylarda hastalar değerlendirildi. Herdeğerlendirmede ultrasonografi ile böbrek boyutları değerlendirildi ve böbrekfonksiyon testleri ölçüldü.Bulgular: Toplam 96 böbreğin doğum öncesi hidronefroz derecesi ile 93böbreğin çalısma sonu hidronefroz derecesinin durumu karsılastırıldığında, çalısmasonunda hidronefroz ciddiyetinin istatistiksel olarak anlamlı derecede azaldığı tespitedildi (p

Published
2009

34. Kronik böbrek yetmezliği olan çocuklarda ateroskleroz ve arter sertliği ile endotel mikropartikül düzeyleri arasındaki ilişkinin in vivo ve in vitro araştırılması

Author

Dursun, İsmail, Poyrazoğlu, Hakan, and Çocuk Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
Abstract

Giris ve amaç: Kronik böbrek yetmezlikli(KBY) hastalarda endotel hasarı ilebaslayan büyük arterlerdeki degisiklikler kardiyovasküler mortalite ve morbiditeninen önemli nedenidir. Arterlerdeki temel degisiklik arteriyel sertlesme ve intimamedia kalınlıgında artıstır. Aktivasyon veya apopitozis endotel hücrelerindenmikropartiküllerin salınmasına yol açar ve endotel fonksiyon bozuklugunu artırır.Çalısmamızın amacı; böbrek yetmezliginin farklı evrelerinde izlenen ve farklı diyalizmodelleri ile tedavi edilen kronik böbrek yetmezlikli çocuklarda, hem arteriyelsertlesme ve intima media kalınlıgı ile endotel kaynaklı mikropartiküllerin arasındakiiliskiyi, hem de kardiyovasküler hastalık risk faktörleri ile arteryal sertlesme, intimamedia kalınlıgı ve endotel kaynaklı mikropartiküller arasındaki iliskinin varlıgınıarastırmaktır.Materyal ve metot: Yasları 2?20 yıl arasında degisen KBY'li 70 hasta (25 peritondiyalizi, 12 hemodiyaliz, 33 konservatif tedavi) ile yas ve cins uyumlu 18 saglıklıkontrol çalısmaya alındı. Çalısma grupları diyaliz, prediyaliz ve kontrol grubu olarakbelirlendi. Olguların antropometrik ve kan basıncı ölçümleri yapıldı, hemoglobin veaçlıkta lipoprotein (a) düzeyleri ölçüldü. Tüm olgularda hem in vivo (CD144+EMP) hem de in vitro (CD146+EMP, HUVEC'de) endotel mikropartikül sayısıölçüldü. Doppler ultrasonografi kullanılarak aortik pulse wave velocity (PWV) vekarotid arter intima-media kalınlıgı (CMK) ölçüldü. Hasta grubunda BUN, kreatinin,albümin, lipitler, Ca, P ALP, PTH ve CRP düzeyleri ölçüldü. Çalısma grupları birbiriile karsılastırıldı. Daha sonra hemodiyaliz ve periton diyaliz grupları arasındakarsılastırma yapıldı.Bulgular:Diyaliz grubunda PWV, karotid arter CMK, CD144 ve CD146+EMP düzeyleriprediyaliz ve kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksekti(p

Published
2007

35. COVID-19 in pediatric nephrology centers in Turkey.

Author

Leventoğlu E, Özdemir Atikel Y, Nalçacioğlu H, Dursun İ, Dursun H, Yürük Yildirim Z, Yildiz N, Kaya Aksoy G, Taşdemir M, Çelakil M, Demircioğlu Kiliç B, Zirhli Selçuk Ş, Canpolat N, Kargin Çakici E, Özlü SG, Tülpar S, Yüksel S, Atmiş B, Sürmeli Döven S, Taner S, Ertan P, Kavaz A, Torun Bayram M, Kalyoncu M, Gülleroğlu K, Kabasakal C, Kasap Demir B, Çiçek RY, Bilge I, Dönmez O, Kara A, Yavaşcan Ö, Özçelik G, Gezgin Yildirim D, Güler MA, Sönmez F, Poyrazoğlu H, Akman S, Topaloğlu R, Alpay H, and Bakkaloğlu SA

Abstract

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey., Materials and Methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11 th March 2020 and 11 th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry., Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period., Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients' susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage., (© TÜBİTAK.)

Published
2022
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36. Evaluation of factors affecting the duration of disease-modifying anti-rheumatic drugs application in patients with enthesitis-related arthritis.

Author

Kısaarslan AP, Sözeri B, Gündüz Z, Zararsız G, Poyrazoğlu H, and Düşünsel R

Abstract

Objective: Treatments for enthesitis-related arthritis (ERA) consist of a mono- or combination therapy with non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs (DMARDs), and biological agents, and they are primarily based on adult studies and studies on other forms of juvenile idiopathic arthritis, depending on whether there is axial or peripheral involvement. We use DMARDs frequently in our daily practice, even in patients with axial involvement. The main reason for this is that the health insurance system in Turkey does not allow the use of Tumor Negrosis Factor (TNF) blockers as the first line of treatment. The aim of this study is to evaluate the factors affecting the duration of DMARDs application in patients with ERA., Methods: Fifty-two patients with ERA were accepted in this retrospective cohort study. These patients did not have an inflammatory bowel disease, reactive arthritis or undifferentiated arthritis, psoriasis, and familial Mediterranean fever. Demographic characteristics, medical history, the initial and follow-up physical examination, initial Juvenile Spondyloarthritis Disease Activity Index (JSpADA), initial laboratory tests, radiographic tests, Juvenile Arthritis Damage Index-articulary (JADI-A) and extra-articulary (JADI-E) on the last admission, and data on medical treatments were recorded from the registered data. The univariate Cox proportional hazards regression analyses was used to determine factors affecting the non-response time of ERA patients to DMARDs before the biological treatment was started., Results: Twenty-seven patients (52%) achieved remission with DMARDs, while 25 (48%) patients did not. The age at diagnosis (HR=1.12; p=0.247); gender (HR=2.53; p=0.210); family history of ankylosing spondylitis (HR=1.17; p=0.730); inflammatory back pain (HR=0.57; p=0.175); the shoulder (HR=0.75 p=0.706), hip (HR=0.45; p=0.129), and small-joint involvement (HR=1.53; p=0.439); sacroiliitis with physical examination (HR=0.90; p=0.814) and magnetic resonance imaging (MRI) (HR=2.84; p=0.110); enthesitis (HR=0.83; p=0.670); presence of uveitis (HR=2.04; p=0.342); presence of HLA-B27 (HR=1.39; p=0.524); initial high acute phase reactants levels(HR=1.89; p=0.183); initial JSpADA score (HR=0.98; p=0.944); and last JADI-A (HR=1.41; p=0.060) score did not affect the duration of DMARDs treatment before switching to biological treatments., Conclusion: In our study, the absence of factors affecting the duration of DMARDs application in patients with ERA showed that DMARDs may still be applied as the first line of treatment.

Published
2019
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37. Voiding cystourethrogram: How much should we be selective?

Author

Yel S, Tülpar S, Düşünsel R, Poyrazoğlu HM, Dursun İ, Abdülrezzak Ü, Gündüz Z, Yılmaz K, and Baştuğ F

Abstract

Objective: In this study, we examined the patients' characteristics, who underwent voiding cystourethrography (VCUG), in order to determine any selectivity for indication of this invasive method., Material and Methods: After exclusion of indications of neurogenic bladder or antenatal hydronephrosis and control VCUGs, 159 VCUGs performed in our clinic within one year were evaluated. Patients are divided into three groups accoding to age. Clinical characteristic and findings of renal ultrasonography (US) and renal scintigraphy were examined., Results: Vesicoureteral reflux (VUR) was detected in 61 (38.3%) of 159 patients who underwent cystourethrographic examinations, in 45.8% of the patients with a history of recurrent urinary tract infection (UTI), in 22.0% of the patients with pathological urinary system US without history of recurrent UTI. High-grade reflux rate was significantly more frequent in renal units with pathological US findings. Severe scar was significantly more frequent in renal units with high-grade reflux when compared to renal units without reflux and those with low-grade reflux. Predictive values of recurrent UTI, scarring status and pathological US for VUR were separately analyzed and seen that likelihood of indicating VUR was increased when all 3 risk factors were assessed together., Conclusion: Vesicoureteral reflux is a problem in which diagnostic process and management strategy should have to be considered in individualized manner for each patient. Before prescribing invasive VCUG, imaging urinary system by US and scintigraphy and determining whether there is recurrent UTI will improve selectivity and success of VCUG., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.

Published
2017
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38. Spider poisoning: a report of six cases from the Central Anatolian region, Turkey.

Author

Akyildiz B, Kurtoğlu S, Poyrazoğlu H, and Ozcan A

Subjects
Adolescent, Child, Diagnosis, Differential, Electrocardiography drug effects, Female, Follow-Up Studies, Humans, Male, Spider Bites diagnosis, Spider Bites therapy, Analgesics therapeutic use, Fluid Therapy methods, Spider Bites epidemiology, Spider Venoms toxicity
Abstract

Spiders exist in every place and ecosystem. Spiders in tropical regions are particularly poisonous and can be dangerous to humans. Nearly 20,000 spider species are known, and almost all are venomous, although only 60 species worldwide are poisonous in humans. In our area, eight species are reported as poisonous in humans. Although most cases of spider bite are benign and require no intervention, severe local and systemic reactions may occur sometimes in the pediatric population, resulting in admission to the pediatric intensive care unit. In this report, we present the cases of six children from the Central Anatolian region in Turkey who were seriously affected by spider bites, and we review the literature on spider envenomation.

Published
2009

39. Diastolic function predicts outcome after aortic valve replacement in patients with chronic severe aortic regurgitation.

Author

Cayli M, Kanadaşi M, Akpinar O, Usal A, and Poyrazoğlu H

Subjects
Adult, Aortic Valve Insufficiency complications, Aortic Valve Insufficiency diagnostic imaging, Aortic Valve Insufficiency physiopathology, Chronic Disease, Diastole, Echocardiography, Doppler, Female, Humans, Hypertrophy, Left Ventricular etiology, Hypertrophy, Left Ventricular physiopathology, Linear Models, Male, Middle Aged, Observer Variation, Predictive Value of Tests, Prospective Studies, Recovery of Function, Reproducibility of Results, Severity of Illness Index, Stroke Volume, Time Factors, Treatment Outcome, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left physiopathology, Aortic Valve Insufficiency surgery, Heart Valve Prosthesis Implantation, Myocardial Contraction, Ventricular Dysfunction, Left etiology
Abstract

Background: Due to eccentric hypertrophy and fibrosis, patients with severe aortic regurgitation (AR) have diastolic dysfunction. Increased fibrosis correlates with increased myocardial stiffness and worsening of diastolic function. Patients with irreversible left ventricular (LV) dysfunction have severe myocardial fibrosis and myocyte apoptosis and do not benefit from aortic valve replacement (AVR)., Hypothesis: To investigate whether diastolic properties of LV predicts outcome after AVR in patients with chronic severe AR and LV systolic dysfunction., Methods: The study population consisted of 41 patients with chronic severe AR and LV systolic dysfunction. Preoperative echocardiographic examinations were repeated at the postoperative 6th month. Left ventricular ejection fraction (LVEF) was calculated. Diastolic function was evaluated with Doppler echocardiography. Patients were classified as Group 1 (impaired relaxation), Group 2 (pseudonormalization), and Group 3 (restrictive pattern)., Results: Postoperative LVEF was significantly increased in Group 1, whereas it tended to decrease in Group 3. Left ventricular size was significantly decreased in Group 1 and 2 during the postoperative period. Multivariate linear regression analysis showed that deceleration time and early/late ratio were independent predictors of postoperative changes in LVEF., Conclusions: Assessment of diastolic function is a reliable parameter in predicting outcome of AVR in patients with chronic AR and systolic dysfunction.

Published
2009
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