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Rationale: The contribution of the adiponectin gene polymorphisms (ADIPOQ, located at 3q27) in the residents of Nigeria and China to the risk of overweight and its association with the risk of arterial hypertension in the European population have been demonstrated.Aim: To identify associations between rs266729 and rs16861194 polymorphisms of the ADIPOQ gene with overweight and obesity in the Moscow region residents.Materials and methods: Identification of rs266729 and rs16861194 polymorphisms of the ADIPOQ gene was carried out in 222 people (140 women and 82 men, aged 25 to 65 years) living in the Moscow region. Genotyping was performed using allele-specific amplification with real-time detection of the results on the CFX96 Real-Time System amplifier (Bio-Rad, USA) and using TaqMan probes complementary to polymorphic DNA regions. To assess an association between these genetic polymorphisms and overweight/obesity, we performed a case control study, with the cases being subjects with body mass index (BMI) of ≥ 30 kg/m2, and the controls those with BMI of < 30 kg/m2.Results: The mean frequency of the minor allele G rs266729 polymorphism of the ADIPOQ gene in the subjects from the Moscow region was 26.8% and similar in men and women. Comparison of the CC and GG genotypes carriers of the rs266729 polymorphism of the ADIPOQ gene in men showed a statistically significant association of the GG genotype to the BMI value (p = 0.04). There were no statistically significant differences between anthropometric indicators (BMI, body fat mass) in the carriers of different rs16861194 polymorphism genotypes of the ADIPOQ. No association between the studied polymorphisms and blood glucose levels and lipid spectrum could be found.Conclusion: The frequency of the minor allele G of the rs266729 polymorphism of the ADIPOQ gene in the subjects from the Moscow region was similar to their rates in the Russian Federation and European countries. In Moscow residents, the rs266729 polymorphism of the ADIPOQ gene (G allele) contributes to the risk of obesity in homozygous carriers (genotype GG). No association of the rs16861194 polymorphism of the ADIPOQ gene with the BMI was found; therefore, this polymorphism cannot be considered as a genetic marker of the obesity risk.

Objective: to study the vitamins level in athletes of various sports. Materials and methods: during the training process, 400 athletes of various sports and specializations were examined: martial artists, game sport athletes, cyclic, complex coordination sports. We assessed the dietery intake of vitamins A, C, B1, B2 and PP and the blood serum level of vitamins A, E, C, B2 and beta-carotene. Results: The assessement the dietary intake of vitamins in relation to the energy value revealed insufficient intake of vitamins B1, B2 and PP in vast majority of the athletes. Only 15.2% of athlets demonstrated adequate level of all vitamins. Most frequently we found a reduced blood serum riboflavin concentration. Conclusions: An increase of B vitamins dietary intake by athletes through a high level of dietary vitamin supplements.

Background: It has been shown that vitamin D availability depends on the body mass index (BMI). Genetic polymorphisms contribute to the development of vitamin D deficiency.Aim: To study the availability of vitamin D in the population of various regions of the Russian Federation, depending on the BMI values and the rs2228570 polymorphisms of the VDR gene and rs9939609 of the FTO gene.Materials and methods: The rs2228570 polymorphisms of the VDR gene and rs9939609 of the FTO gene were identified in 311 subjects (136, from the midland of Russia, and 175 from the Far North). Serum 25-hydroxyvitamin D [25(OH)D] levels were measured by an immunoenzyme assay in the autumn and winter seasons. Genotyping was performed with the allele-specific amplification and real-time detection of results using TaqMan probes complementary to the polymorphic DNA segments and the CFX96 Real Time System amplifier (Bio-Rad, USA). We studied associations of the rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene located at 16q12.2, as well as the rs2228570 polymorphism of the vitamin D receptor gene (VDR) located at 12q13.11.Results: Frank vitamin D deficiency (serum 25 (OH) D levelConclusion: The association between obesity and vitamin D availability in the individuals with the rs2228570 polymorphism of the VDR gene and the rs9939609 polymorphism of the FTO gene depends on their ethnicity.

The study of actual nutrition and nutritional status was conducted in 180 residents of the settlements of Tazovsky and Gyda of the Yamal-Nenets Autonomous District. In comparison with the out-of-town population, Arctic indigenous people reliably consume bakery products, meat products (due to venison), fish and fish products, and less - dairy products, vegetables and mushrooms, fruits, berries, dried fruit, vegetable, fruit and fruit juices. When analyzing the chemical composition of the diet, in comparison with the indices of the newborn population, the caloric content of the ration was significantly higher because of its higher protein content (18% of calories). The fat content in the diet of the indigenous population was almost close to the recommended values (30% by caloric content), while in the alien population it exceeded them (33%). The indigenous population, in comparison with the out-of-home population, had a lower content of total and animal fat in the diet, mono- and disaccharides against a background of lower BMI (27.2 kg / m2 and 28.8 kg / m2, respectively) and fat mass. Body factors also were affected by genetic factors. The indigenous population consumed less Vitamin C (2 times) compared to the alien, which was due to the significantly lower content of vegetables, fruits, berries and fruit juices in their diet, and Ca at an unfavorable ratio of Ca: P (1: 2.5) On the background of insufficient intake of dairy products, and more - sodium due to canned (smoked, dried and salted) fish.