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1,250 results on '"Plymouth University"'

1. Preventing Relapse to Smoking Among Prisoners After Release (PROSPER)

Author: Her Majesty's Prison and Probation Service (HMPPS), Public Health England, Cancer Research UK, and Plymouth University Peninsula Schools of Medicine & Dentistry (PUPSMD)
Published: 2024

2. Do Good Non-Technical Skills Correlate With Good Clinical Outcomes in Endoscopy?

Author: Torbay and South Devon NHS Foundation Trust and Plymouth University Peninsula Schools of Medicine & Dentistry
Published: 2023

3. Taking sides? Aspect has limited influence on soil environment or litter decomposition in pan-European study of roadside verges

Author: Plymouth University, Ministerio de Economía y Competitividad (España), Research Foundation - Flanders, Gómez Aparicio, Lorena [0000-0001-5122-3579], Graae, B. J. [0000-0002-5568-4759], Vangansbeke, Pieter [0000-0002-6356-2858], Amstutz, A., Firth, Louise, Spicer, John I., De Frenne, Pieter, Gómez Aparicio, Lorena, Graae, B. J., Kuś, S., Lindmo, S., Orczewska, A., Rodríguez-Sánchez, Francisco, Vangansbeke, Pieter, Vanneste, Thomas, Hanley, Mick E., Plymouth University, Ministerio de Economía y Competitividad (España), Research Foundation - Flanders, Gómez Aparicio, Lorena [0000-0001-5122-3579], Graae, B. J. [0000-0002-5568-4759], Vangansbeke, Pieter [0000-0002-6356-2858], Amstutz, A., Firth, Louise, Spicer, John I., De Frenne, Pieter, Gómez Aparicio, Lorena, Graae, B. J., Kuś, S., Lindmo, S., Orczewska, A., Rodríguez-Sánchez, Francisco, Vangansbeke, Pieter, Vanneste, Thomas, and Hanley, Mick E.
Abstract: In addition to well-known effects on species ecophysiology, phenology, and distributions, climate change is widely predicted to impact essential ecosystem services such as decomposition and nutrient cycling. While temperature and soil moisture are thought to influence litter decomposition, elucidating consistent soil process responses to observed or predicted shifts in climate have proven difficult to evidence. Here we investigated how aspect (i.e., north-south orientation), a natural model for variation in soil temperature, influenced soil physico-chemical conditions and decomposition of two standardised litter types (Green tea and Rooibos teabags) in Pole-facing (PF) and Equator-facing (EF) roadside verges spanning a 3000 km and 27° latitudinal gradient across Europe. Despite average daily temperatures being 1.5 - 3.0 °C warmer on EF than PF slopes, there were only minor region-specific differences in initial soil physico-chemical conditions and short-term variation in litter decomposition (i.e., litter mass loss was higher in EF-verges for the first month of deployment only) associated with aspect. We conclude that previously observed differences in soil environments and the decomposition process associated with slope orientation, is largely litter or environment specific, although medium-term soil-decomposition in semi-natural grassland ecosystems may also be insensitive to the magnitude of temperature variation within the range predicted by the IPCC SSP1–2.6 emissions scenario. Nonetheless, consistent average and extreme temperature differences between adjacent PF- and EF-aspects along roadside verges provides a model system to explore exactly how resilient the soil environment and the micro-organisms responsible for decomposition, are to temperature variation.
Published: 2024

4. The impact of the Covid-19 pandemic on teleworking and the logistics of work in Egypt

Author: Leat, Mike; Plymouth University, Plymouth, El-Kot, Ghada; Arab Academy for Science, Technology and Maritime Transport, Leat, Mike; Plymouth University, Plymouth, and El-Kot, Ghada; Arab Academy for Science, Technology and Maritime Transport
Abstract: Purpose: The aim of this paper is to investigate the impact of the Covid-19 pandemic on the implementation of teleworking and other flexible work practices, and the logistics of work in Egypt. Design/Methodology / approach: A review of relevant literature and a survey were conducted. The survey data was collected from a purposive sample of women working in professional and managerial roles in Alexandria and Cairo. The data was collected online between March and May in 2021. The questionnaire was in English. A sample of 1089 employees participated in the study. Data was collected on the perceived impact of the Covid-19 pandemic on employing organizations implementation of teleworking, other flexible work practices and childcare provision. A range of demographic and employing organization data was collected. Paired comparison and T-test analysis were employed in this study. Findings: The survey results indicated that before Covid-19 implementation of flexible working policies, workplace childcare and childcare allowances was limited. However, Covid-19 is significant in explaining marked increases in the implementation of all the flexible working policies and across all organisational ownership types and size groupings, this is not the case for the policies on childcare where there has been little change to rates of affirmation of implementation. Ownership type and organisational size were also significant in explaining some of the variations in rates of perceived implementation both before and after the pandemic.Research implication/limitation: The study has limitations in terms of the sample being limited to women working in professional and managerial roles in Alexandria and Cairo, the results are therefore not generalisable. Nevertheless, it provides evidence of and confirmed the significant influence of Covid-19 on the incidence of teleworking and other flexible work practices in Egypt. Research is needed to investigate this impact amongst a wider population. Re
Published: 2022

5. Generation of a conjoint surface plasmon by an infrared nano-antenna array

Author: Aston University, Plymouth University, University of Hull, Engineering and Physical Sciences Research Council (UK), National Natural Science Foundation of China, European Commission, Ministerio de Ciencia e Innovación (España), Comunidad de Madrid, Higher Learning Institutions in Shanghai Municipality, Allsop, Thomas D.P., Mou, Chengbo, Neal, Ronald, Kundrat, V., Wang, Changle, Kalli, K., Webb, David, Liu, Xiaoping, Davey, Paul, Culverhouse, P., Ania Castañón, Juan Diego, Aston University, Plymouth University, University of Hull, Engineering and Physical Sciences Research Council (UK), National Natural Science Foundation of China, European Commission, Ministerio de Ciencia e Innovación (España), Comunidad de Madrid, Higher Learning Institutions in Shanghai Municipality, Allsop, Thomas D.P., Mou, Chengbo, Neal, Ronald, Kundrat, V., Wang, Changle, Kalli, K., Webb, David, Liu, Xiaoping, Davey, Paul, Culverhouse, P., and Ania Castañón, Juan Diego
Abstract: Localized surface plasmons (LSP) excited by optical fields have many potential applications resulting from their ability in detecting ultra-small, ambient refractive index change. Current methods using surface nano-patterning by means of lithography have given rise to LSP of limited propagation and interaction lengths, meaning that practical applications remain challenging. This article describes a new all-optical method of generating LSP by means of a carefully fabricated low-dimensional nano-structured material using a direct-write photochemical lithography. It is shown that the resulting array of localized SPs combine or “Conjoin” to have an unprecedented large interaction length, via coupled evanescent fields, giving rise to superior spectral sensitivities; several orders of magnitude better than those quoted elsewhere and reaching 6 × 103 nm RIU−1 in the aqueous regime and 104 nm RIU−1 in the gaseous regime. Numerical modeling is performed that shows this design of plasmonic platform is capable of producing sensitivities of 105–106 nm RIU−1. It is believed the results achieved in this investigation show that a unique conjoint SP operational mode will significantly impact areas of interest, such as single molecular dynamics, drug delivery systems, etc.
Published: 2021

6. An ultra-sensitive aptasensor on optical fibre for the direct detection of bisphenol A

Author: Aston University, Plymouth University, Engineering and Physical Sciences Research Council (UK), Ministero dell'Istruzione, dell'Università e della Ricerca, Allsop, Thomas D.P., Neal, R., Wang, C., Nagel, D. A., Hine, A. V., Culverhouse, P., Ania Castañón, Juan Diego, Webb, D. J., Scarano, S., Minunni, M., Aston University, Plymouth University, Engineering and Physical Sciences Research Council (UK), Ministero dell'Istruzione, dell'Università e della Ricerca, Allsop, Thomas D.P., Neal, R., Wang, C., Nagel, D. A., Hine, A. V., Culverhouse, P., Ania Castañón, Juan Diego, Webb, D. J., Scarano, S., and Minunni, M.
Abstract: We present a plasmonic biosensor capable of detecting the presence of bisphenol A in ultra-low concentrations, yielding a wavelength shift of 0.15 ± 0.01 nm in response to a solution of 1 fM concentration with limit of detection of 330 ± 70 aM The biosensing device consists of an array of gold nano-antennae with a total length of 2.3 cm that generate coupled localised surface plasmons (cLSPs) and is covalently modified with an aptamer specific for bisphenol A recognition. The array of nano-antennae is fabricated on a lapped section of standard telecommunication optical fibre, allowing for potential multiplexing and its use in remote sensing applications. These results have been achieved without the use of enhancement techniques and therefore the approach allows the direct detection of bisphenol A, a low molecular weight (228 Da) target usually detectable only by indirect detection strategies. Its detection at such levels is a significant step forward in measuring small molecules at ultra-low concentrations. Furthermore, this new sensing platform paves the way for the development of portable systems for in-situ agricultural measurements capable of retrieving data on a substance of very high concern at ultra-low concentrations.
Published: 2019

7. Identification of the direct regulon of NtcA during early acclimation to nitrogen starvation in the cyanobacterium Synechocystis sp. PCC 6803

Author: Fundação para a Ciência e a Tecnologia (Portugal), Ministerio de Economía y Competitividad (España), Junta de Andalucía, European Commission, Plymouth University, Giner-Lamia, Joaquín, Robles-Rengel, Rocío, Hernández-Prieto, Miguel A., Muro-Pastor, M. Isabel, Florencio, Francisco J., Futschik, Matthias E., Fundação para a Ciência e a Tecnologia (Portugal), Ministerio de Economía y Competitividad (España), Junta de Andalucía, European Commission, Plymouth University, Giner-Lamia, Joaquín, Robles-Rengel, Rocío, Hernández-Prieto, Miguel A., Muro-Pastor, M. Isabel, Florencio, Francisco J., and Futschik, Matthias E.
Abstract: In cyanobacteria, nitrogen homeostasis is maintained by an intricate regulatory network around transcription factor NtcA. Although mechanisms controlling NtcA activity appear to be well understood, its regulon remains poorly defined. To determine the NtcA regulon during the early stages of nitrogen starvation for the model cyanobacterium Synechocystis sp. PCC 6803, we performed chromatin immunoprecipitation, followed by sequencing (ChIP-seq), in parallel with transcriptome analysis (RNA-seq). Through combining these methods, we determined 51 genes activated and 28 repressed directly by NtcA. In addition to genes associated with nitrogen and carbon metabolism, a considerable number of genes without current functional annotation were among direct targets providing a rich reservoir for further studies. The NtcA regulon also included eight non-coding RNAs, of which Ncr1071, Syr6 and NsiR7 were experimentally validated, and their putative targets were computationally predicted. Surprisingly, we found substantial NtcA binding associated with delayed expression changes indicating that NtcA can reside in a poised state controlled by other factors. Indeed, a role of PipX as modulating factor in nitrogen regulation was confirmed for selected NtcA-targets. We suggest that the indicated poised state of NtcA enables a more differentiated response to nitrogen limitation and can be advantageous in native habitats of Synechocystis.
Published: 2017

8. Antarctic sea ice region as a source of biogenic organic nitrogen in aerosols

Author: Ministerio de Economía y Competitividad (España), Consiglio Nazionale delle Ricerche, European Commission, Natural Environment Research Council (UK), Plymouth University, Dall'Osto, Manuel, Cortes, Pau, Zamanillo Campos, Marina, Nunes, Sdena, Ortega-Retuerta, E., Emelianov, Mikhail, Vaqué, Dolors, Marrasé, Cèlia, Estrada, Marta, Sala, M. Montserrat, Simó, Rafel, Ministerio de Economía y Competitividad (España), Consiglio Nazionale delle Ricerche, European Commission, Natural Environment Research Council (UK), Plymouth University, Dall'Osto, Manuel, Cortes, Pau, Zamanillo Campos, Marina, Nunes, Sdena, Ortega-Retuerta, E., Emelianov, Mikhail, Vaqué, Dolors, Marrasé, Cèlia, Estrada, Marta, Sala, M. Montserrat, and Simó, Rafel
Abstract: Climate warming affects the development and distribution of sea ice, but at present the evidence of polar ecosystem feedbacks on climate through changes in the atmosphere is sparse. By means of synergistic atmospheric and oceanic measurements in the Southern Ocean near Antarctica, we present evidence that the microbiota of sea ice and sea ice-influenced ocean are a previously unknown significant source of atmospheric organic nitrogen, including low molecular weight alkyl-amines. Given the keystone role of nitrogen compounds in aerosol formation, growth and neutralization, our findings call for greater chemical and source diversity in the modelling efforts linking the marine ecosystem to aerosol-mediated climate effects in the Southern Ocean
Published: 2017

9. Late-glacial and Holocene European pollen data

Author: Basil A. S. Davis, Steffen Wolters, Graciela Gil-Romera, Richard H. W. Bradshaw, Walter Finsinger, Ralph Fyfe, Heather Binney, Michelle Leydet, Petr Kuneš, Jacques-Louis de Beaulieu, Thomas Giesecke, Norbert Kühl, Simon Brewer, University of Utah, Georg-August-Universität Göttingen, Université de Genève ( UNIGE ), Centre de Bio-Archéologie et d'Ecologie ( CBAE ), Université Montpellier 2 - Sciences et Techniques ( UM2 ) -École pratique des hautes études ( EPHE ) -Centre National de la Recherche Scientifique ( CNRS ), University of Southampton [Southampton], Institut méditerranéen de biodiversité et d'écologie marine et continentale ( IMBE ), Centre National de la Recherche Scientifique ( CNRS ) -Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université ( AMU ) -Université d'Avignon et des Pays de Vaucluse ( UAPV ), School of Geography, University of Plymouth-University of Plymouth, Instituto Pirenaico de Ecologia, Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Steinmann-Institut für Geologie, Mineralogie und Paläontologie, Bonn Universität [Bonn], Charles University [Prague], School of Environmental Sciences, University of Liverpool, University of Liverpool, Department of Geography, University of Liverpool-University of Liverpool, ÉcolePolytechniqueFédérale de Lausanne (EPFL), School of Architecture, Civil and Environmental, Institut des Sciences de l'Evolution de Montpellier ( ISEM ), Université de Montpellier ( UM ) -Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique ( CNRS ), Institut Méditerranéen d'Ecologie et de Paléoécologie ( IMEP ), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Centre National de la Recherche Scientifique ( CNRS ), Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Aix Marseille Université ( AMU ) -Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique ( CNRS ), Georg-August-University = Georg-August-Universität Göttingen, Université de Genève = University of Geneva (UNIGE), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), University of Southampton, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Plymouth University-Plymouth University, Instituto Pirenaico de Ecologìa = Pyrenean Institute of Ecology [Zaragoza] (IPE - CSIC), Rheinische Friedrich-Wilhelms-Universität Bonn, Charles University [Prague] (CU), Georg-August-University [Göttingen], Université de Genève (UNIGE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Instituto Pirenaico de Ecologia (IPE), and Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: 010506 paleontology, 010504 meteorology & atmospheric sciences, [ SDV.BV.BOT ] Life Sciences [q-bio]/Vegetal Biology/Botanics, Geography, Planning and Development, medicine.disease_cause, 01 natural sciences, [ SDV.SA.SF ] Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, Abundance (ecology), vegetation, lcsh:G3180-9980, Pollen, Earth and Planetary Sciences (miscellaneous), medicine, [ SDU.ENVI ] Sciences of the Universe [physics]/Continental interfaces, environment, Glacial period, Environmental history, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Holocene, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, lcsh:Maps, [ SDE.BE ] Environmental Sciences/Biodiversity and Ecology, Vegetation, 15. Life on land, Europe, [ SDE.MCG ] Environmental Sciences/Global Changes, Taxon, Geography, Climatology, European Pollen Database, late-glacial, Physical geography, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, [ SDE.ES ] Environmental Sciences/Environmental and Society
Abstract: International audience; The European Pollen Database (EPD) is a community effort to archive and make available pollen sequences from across the European continent. Pollen sequences provide records that may be used to infer past vegetation and vegetation change. We present here maps based on 828 sites from the EPD giving an overview of changes in postglacial pollen assemblages in Europe over the past 15,000 years. The maps show the distribution and abundance of 54 different pollen taxa at 500 year intervals, supported by new age-depth models and associated chronological uncertainty analysis. Results show the individualistic patterns of spread of different pollen taxa, and provide a standardized dataset for further analysis, defining a spatial context for the study of past plant and vegetation changes and other aspects of environmental history in Europe.
Published: 2017
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10. A decision support system for evaluation of the knowledge sharing crossing boundaries in agri-food value chains

Author: Alejandro Fernández, Shaofeng Liu, Biljana Mileva Boshkoska, Pascale Zaraté, Huilan Chen, Jorge E. Hernández, Guoqing Zhao, Mariana del Pino, Susana Gamboa, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Universidad Nacional de la Plata - UNLP (ARGENTINA), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), Institut 'Jožef Stefan' - IJS (SLOVENIA), Plymouth University (UNITED KINGDOM), University of Liverpool (UNITED KINGDOM), Institut de Recherche en Informatique de Toulouse - IRIT (Toulouse, France), Jozef Stefan Institute [Ljubljana] (IJS), University of Liverpool, Plymouth University, Universidad Nacional de la Plata [Argentine] (UNLP), Argumentation, Décision, Raisonnement, Incertitude et Apprentissage (IRIT-ADRIA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), and Université Fédérale Toulouse Midi-Pyrénées
Subjects: Ingenierías y Tecnologías, 0209 industrial biotechnology, Decision support system, Knowledge management, Knowledge sharing, General Computer Science, Computer science, Interoperability, Ciencias Informáticas, 02 engineering and technology, Decision support systems, Ontology (information science), 020901 industrial engineering & automation, Common knowledge, 0202 electrical engineering, electronic engineering, information engineering, business.industry, Agricultural value chain, General Engineering, Recherche d'information, Identification (information), [INFO.INFO-IR]Computer Science [cs]/Information Retrieval [cs.IR], Transparency (graphic), Knowledge boundaries, 020201 artificial intelligence & image processing, business
Abstract: An agri-food value chain (VC) represents a set of activities aimed at delivering highly valuable products to the market. Due to the diversity of actors in the agri-food VCs ́ accumulated knowledge is typically situated within the boundaries of each entity of the VC. Hence, the question is how to improve knowledge sharing in agri-food VC, or more specifically how can knowledge flow and mobilize among different actors in the VC. To answer this question, we present a decision support system (DSS) for evaluation of knowledge sharing crossing boundaries in agri-food VC. The proposed DSS is developed through two phases: (i) identification of the most common knowledge boundaries by using machine learning and ontology technologies; (ii) transformation of the obtained ontology into a DSS for the evaluation of existing knowledge boundaries. In particular, the developed DSS helps in identifying, evaluating and providing directions for improvement of the knowledge sharing crossing boundaries in agri-food VC. We apply the DSS to evaluate three real VCs: a tomato VC in Argentina, a Chinese leaf VC in China and a brassica VC in the UK. The comparative analysis across the three varied case studies and their evaluation with the proposed DSS lead to more insights into knowledge-based decisions that a particular VC needs to address to improve its knowledge flow, in particular, to obtain insights in the transparency and interoperability of data and knowledge crossing boundaries in agri-food VCs., Laboratorio de Investigación y Formación en Informática Avanzada
Published: 2019
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11. Holocene landscape dynamics and long-term population trends in the Levant

Author: Alessio Palmisano, Andrew Bevan, Andrea Miebach, Ralph Fyfe, C. Neil Roberts, Thomas Litt, Jessie Woodbridge, Raphael Greenberg, Suzanne A.G. Leroy, Stephen Shennan, Rachid Cheddadi, David Kaniewski, Dafna Langgut, University College of London [London] (UCL), School of Geography, Earth and Environmental Sciences [Plymouth] (SoGEES), Plymouth University, Plymouth University, Plymouth, United Kingdom, Institute of archaeology (UCL), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226, L'Homme préhistorique : son évolution, son milieu, ses activités, Université de la Méditerranée - Aix-Marseille 2-Muséum national d'Histoire naturelle (MNHN)-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Institute of Paleontology, Rheinische Friedrich-Wilhelms-Universität Bonn, School of Geography, Plymouth University-Plymouth University, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Laboratoire Ecologie Fonctionnelle et Environnement (ECOLAB), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)
Subjects: demography, 010506 paleontology, Archeology, Population, settlement patterns, Wetland, Woodland, medicine.disease_cause, 01 natural sciences, Grassland, law.invention, vegetation, law, Pollen, medicine, archaeology, climate, Levant, pollen, 0601 history and archaeology, Radiocarbon dating, education, Holocene, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Earth-Surface Processes, Global and Planetary Change, geography, education.field_of_study, geography.geographical_feature_category, 060102 archaeology, Ecology, Paleontology, 06 humanities and the arts, Vegetation, 15. Life on land, [SDE.ES]Environmental Sciences/Environmental and Society, [SDE]Environmental Sciences, Physical geography
Abstract: International audience; This paper explores long-term trends in human population and vegetation change in the Levant from the early to the late Holocene in order to assess when and how human impact has shaped the region’s landscapes over the millennia. To do so, we employed multiple proxies and compared archaeological, pollen and palaeoclimate data within a multi-scalar approach in order to assess how Holocene landscape dynamics change at different geographical scales. We based our analysis on 14 fossil pollen sequences and applied a hierarchical agglomerative clustering and community classification in order to define groups of vegetation types (e.g. grassland, wetland, woodland, etc.). Human impact on the landscape has been assessed by the analysis of pollen indicator groups. Archaeological settlement data and Summed Probability Distribution (SPD) of radiocarbon dates have been used to reconstruct long-term demographic trends. In this study, for the first time, the evolution of the human population is estimated statistically and compared with environmental proxies for assessing the interplay of biotic and abiotic factors in shaping the Holocene landscapes in the Levant.
Published: 2019
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12. Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial

Author: Priti Patel, Raquel Izumi, Richa Dua, Eric D. Jacobsen, Ahmed Hamdy, Stephen D. Smith, Pier Luigi Zinzani, Jeanette K. Doorduijn, Lucie Oberic, Andrew Davies, Andre Goy, Arnon P. Kater, Wayne Rothbaum, Carlos Panizo, Taduesz Robak, Franck Morschhauser, Thierry Lamy, Simon Rule, Todd Covey, Richard Eek, Steven Le Gouill, Jehan Dupuis, J. Greg Slatter, Michael Wang, Xin Huang, Gandhi Damaj, Olivier Casasnovas, Bijal D. Shah, Wojciech Jurczak, Wang, Michael, Rule, Simon, Zinzani, Pier Luigi, Goy, Andre, Casasnovas, Olivier, Smith, Stephen D, Damaj, Gandhi, Doorduijn, Jeanette, Lamy, Thierry, Morschhauser, Franck, Panizo, Carlo, Shah, Bijal, Davies, Andrew, Eek, Richard, Dupuis, Jehan, Jacobsen, Eric, Kater, Arnon P, Le Gouill, Steven, Oberic, Lucie, Robak, Taduesz, Covey, Todd, Dua, Richa, Hamdy, Ahmed, Huang, Xin, Izumi, Raquel, Patel, Priti, Rothbaum, Wayne, Slatter, J. Greg, Jurczak, Wojciech, Hematology, Department of Lymphoma and Myeloma [Houston, TX, USA], The University of Texas M.D. Anderson Cancer Center [Houston], Department of Stem Cell Transplantation and Cellular Therapy [Houston, TX, USA], Plymouth University Medical School [Plymouth, UK], The Institute of Hematology and Oncology L. and A. Seràgnoli [Bologna, Italy], Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), John Theurer Cancer Center [Hackensack, NJ, USA], Hackensack University Medical Center [Hackensack], Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hématologie Clinique (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Institut d'Hématologie de Basse-Normandie (IHBN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, Erasmus Medical Centre [Rotterdam, The Netherlands], HOVON Lunenburg Lymphoma Phase I/II Consortium [Amsterdam, The Netherlands], CHU Pontchaillou [Rennes], Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Clínica Universidad de Navarra [Pamplona, Spain], H. Lee Moffitt Cancer Center and Research Institute, Cancer Sciences Unit [Southampton, UK] (Cancer Research UK Centre), University of Southampton, Faculty of Medicine [Southampton, UK], Border Medical Oncology [Wodonga, VIC, Australia], Unité des hémopathies lymphoïdes [CHU Henri Mondor], CHU Henri Mondor, Dana-Farber Cancer Institute [Boston], Harvard Medical School [Boston] (HMS), Academic Medical Center [Amsterdam, Netherlands], Hôpital Hôtel-Dieu de Nantes - Centre Hospitalier Universitaire de Nantes (Hôpital Hôtel-Dieu de Nantes - CHU de Nantes), Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma (CRCINA-ÉQUIPE 10), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Medical University of Łódź (MUL), Acerta Pharma (Redwood City, CA), Department of Hematology [Krakow, Poland], Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Acerta Pharma, a member of the AstraZeneca Group., Department of Haematology, Derriford Hospital, L. and A. Seràgnoli Hospital, University of Bologna, John Theurer Cancer Center - Hackensack University Medical Center, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Fred Hutchinson Cancer Research Center [Seattle] ( FHCRC ), CHU Caen, Erasmus University Medical Centre Rotterdam [Rotterdam], Biophysique, Médecine Nucléaire et Technologies Médicales ( EA 1049 ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Hematology Service, Clínica Universitaria, Universidad de Navarra [Pamplona] ( UNAV ), H. Lee Moffitt Cancer Center & Research Institute, Electrical Engineering University of Leeds, Service d'hématologie clinique, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Centre de Recherche en Cancérologie / Nantes - Angers ( CRCNA ), CHU Angers-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Hôpital Laennec-Centre National de la Recherche Scientifique ( CNRS ) -Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes ( CHU Nantes ), Institut Universitaire du Cancer de Toulouse - Oncopole ( IUCT Oncopole - UMR 1037 ), Université Paul Sabatier - Toulouse 3 ( UPS ) -CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Medical University of Lodz, Copernicus Memorial Hospital, Jagiellonian University [Krakow] ( UJ ), Clinical Haematology, CCA - Cancer Treatment and Quality of Life, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Biophysique, Médecine Nucléaire et Technologies Médicales (EA 1049), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Universidad de Navarra [Pamplona] (UNAV), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Jagiellonian University [Krakow] (UJ), Bernardo, Elizabeth, Plymouth University, Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), CCA - Cancer Treatment and quality of life, CHU Henri Mondor [Créteil], and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: 0301 basic medicine, Male, medicine.medical_specialty, Population, Phases of clinical research, [SDV.CAN]Life Sciences [q-bio]/Cancer, Lymphoma, Mantle-Cell, Neutropenia, Gastroenterology, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Recurrence, Internal medicine, medicine, Clinical endpoint, Humans, education, Protein Kinase Inhibitors, Survival analysis, Aged, Tyrosine kinase inhibitors, education.field_of_study, Mantle cell lymphoma, Dose-Response Relationship, Drug, business.industry, Acalabrutinib, General Medicine, Middle Aged, medicine.disease, Survival Analysis, 3. Good health, 030104 developmental biology, Treatment Outcome, 030220 oncology & carcinogenesis, Pyrazines, Benzamides, Refractory Mantle Cell Lymphoma, Female, business, Progressive disease
Abstract: International audience; BACKGROUND:Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma. Acalabrutinib (ACP-196) is a highly selective, potent Bruton tyrosine kinase inhibitor developed to minimise off-target activity.METHODS:In this open-label, phase 2 study, oral acalabrutinib (100 mg twice per day) was given to patients with relapsed or refractory mantle cell lymphoma, until disease progression or unacceptable toxicity. The primary endpoint was overall response assessed according to the Lugano classification, and safety analyses were done in all participants. This trial is registered with ClinicalTrials.gov, number NCT02213926.FINDINGS:From March 12, 2015, to Jan 5, 2016, 124 patients with relapsed or refractory mantle cell lymphoma were enrolled and all patients received treatment; median age 68 years. Patients received a median of two (IQR 1-2) previous therapies. At a median follow-up of 15·2 months, 100 (81%) patients achieved an overall response and 49 (40%) patients achieved a complete response. The Kaplan-Meier estimated medians for duration of response, progression-free survival, and overall survival were not reached; the 12-month rates were 72% (95% CI 62-80), 67% (58-75), and 87% (79-92%), respectively. The most common adverse events were primarily grade 1 or 2 and were headache (47 [38%]), diarrhoea (38 [31%]), fatigue (34 [27%]), and myalgia (26 [21%]). The most common grade 3 or worse adverse events were neutropenia (13 [10%]), anaemia (11 [9%]), and pneumonia (six [5%]). There were no cases of atrial fibrillation and one case of grade 3 or worse haemorrhage. The median duration of treatment was 13·8 months. Treatment was discontinued in 54 (44%) patients, primarily due to progressive disease (39 [31%]) and adverse events (seven [6%]).INTERPRETATION:Acalabrutinib treatment provided a high rate of durable responses and a favourable safety profile in patients with relapsed or refractory mantle cell lymphoma. These findings suggest an important role for acalabrutinib in the treatment of this disease population.FUNDING:Acerta Pharma, a member of the AstraZeneca Group.Copyright © 2017 Elsevier Ltd. All rights reserved.
Published: 2018
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13. Constraining the deforestation history of Europe: Evaluation of historical land use scenarios with pollen-based land cover reconstructions

Author: Anne Birgitte Nielsen, Shinya Sugita, Ralph Fyfe, Anna-Kari Trondman, Kristen M. Krumhardt, Marie-José Gaillard, Jed O. Kaplan, Laurent Marquer, Florence Mazier, Department of Archaeogenetics [Jena] (DAG), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, University of Colorado [Boulder], Department of Biology and Environmental Science, Linnaeus University, Institute of Ecology, Tallinn University-Tallinn University, Department of Biology and Environmental Science, School of Geography, Plymouth University-Plymouth University, Géographie de l'environnement (GEODE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), and Department of Geology, Lund University, Sölvegatan 12, SE-22362 Lund, Sweden
Subjects: 010506 paleontology, 010504 meteorology & atmospheric sciences, Biodiversity, Land cover, environmental history, 01 natural sciences, paleoecology, Ecosystem services, lcsh:Agriculture, land use, human-environment interactions, Deforestation, Holocene, 0105 earth and related environmental sciences, Nature and Landscape Conservation, Global and Planetary Change, Ecology, Land use, lcsh:S, Vegetation, [SHS.GEO]Humanities and Social Sciences/Geography, 15. Life on land, Earth system science, 13. Climate action, Environmental science, Physical geography
Abstract: International audience; Anthropogenic land cover change (ALCC) is the most important transformation of the Earth system that occurred in the preindustrial Holocene, with implications for carbon, water and sediment cycles, biodiversity and the provision of ecosystem services and regional and global climate. For example, anthropogenic deforestation in preindustrial Eurasia may have led to feedbacks to the climate system: both biogeophysical, regionally amplifying winter cold and summer warm temperatures, and biogeochemical, stabilizing atmospheric CO 2 concentrations and thus influencing global climate. Quantification of these effects is difficult, however, because scenarios of anthropogenic land cover change over the Holocene vary widely, with increasing disagreement back in time. Because land cover change had such widespread ramifications for the Earth system, it is essential to assess current ALCC scenarios in light of observations and provide guidance on which models are most realistic. Here, we perform a systematic evaluation of two widely-used ALCC scenarios (KK10 and HYDE3.1) in northern and part of central Europe using an independent, pollen-based reconstruction of Holocene land cover (REVEALS). Considering that ALCC in Europe primarily resulted in deforestation, we compare modeled land use with the cover of non-forest vegetation inferred from the pollen data. Though neither land cover change scenario matches the pollen-based reconstructions precisely, KK10 correlates well with REVEALS at the country scale, while HYDE systematically underestimates land use with increasing magnitude with time in the past. Discrepancies between modeled and reconstructed land use are caused by a number of factors, including assumptions of per-capita land use and socio-cultural factors that cannot be predicted on the basis of the characteristics of the physical environment, including dietary preferences, long-distance trade, the location of urban areas and social organization.
Published: 2017
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14. Simulations of the Holocene climate in Europe using an interactive downscaling within the iLOVECLIM model (version 1.1)

Author: Frank Arthur, Didier M. Roche, Ralph Fyfe, Aurélien Quiquet, Hans Renssen, Earth Sciences, University of South-Eastern Norway (USN), Vrije Universiteit Amsterdam [Amsterdam] (VU), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Modélisation du climat (CLIM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), School of Geography, Earth and Environmental Sciences [Plymouth] (SoGEES), and Plymouth University
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Global and Planetary Change, Stratigraphy, SDG 13 - Climate Action, Paleontology, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment
Abstract: This study presents the application of an interactive downscaling in Europe using iLOVECLIM (a model of intermediate complexity), increasing its atmospheric resolution from 5.56 to 0.25∘ kilometric. A transient simulation using the appropriate climate forcings for the entire Holocene (11.5–0 ka BP) was done for both the standard version of the model and with an interactive downscaling applied. Our results show that simulations from downscaling present spatial variability that agrees better with proxy-based reconstructions and other climate models as compared to the standard model. The downscaling scheme simulates much higher (by at least a factor of 2) precipitation maxima and provides detailed information in mountainous regions. We focus on examples from the Scandes mountains, the Alps, the Scottish Highlands, and the Mediterranean. The higher spatial resolution of the downscaling provides a more realistic overview of the topography and gives local climate information, such as precipitation and temperature gradient, that is important for paleoclimate studies. With downscaling, we simulate similar trends and spatial patterns of the precipitation changes reconstructed by other proxy studies (for example in the Alps) as compared to the standard version. Our downscaling tool is numerically cheap, implying that our model can perform kilometric, multi-millennial simulations and is suitable for future studies.
Published: 2023
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15. Tracking Hunter-Gatherer Impact on Vegetation in Last Interglacial and Holocene Europe

Author: Nikulina, Anastasia, Macdonald, Katharine, Scherjon, Fulco, A. Pearce, Elena, Davoli, Marco, Svenning, Jens-Christian, Vella, Emily, Gaillard, Marie-José, Zapolska, Anhelina, Arthur, Frank, Martinez, Alexandre, Hatlestad, Kailin, Mazier, Florence, Serge, Maria Antonia, Lindholm, Karl-Johan, Fyfe, Ralph, Renssen, Hans, Roche, Didier, Kluiving, Sjoerd, Roebroeks, Wil, Serge, Maria, Universiteit Leiden, Aarhus University [Aarhus], Uppsala University, Linnaeus University, Vrije Universiteit Amsterdam [Amsterdam] (VU), University of South-Eastern Norway (USN), Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Plymouth University, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Modélisation du climat (CLIM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Earth and Climate, CLUE+, Art and Culture, History, Antiquity, Earth Sciences, Amsterdam Sustainability Institute, Leiden University, Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, 010506 paleontology, Archeology, 010504 meteorology & atmospheric sciences, Holocene, 15. Life on land, Human-environment interaction, Mesolithic, Neanderthal, Last Interglacial, Hunter-gatherers, 01 natural sciences, Archaeology, 13. Climate action, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Arkeologi, 0105 earth and related environmental sciences
Abstract: We review palaeoenvironmental proxies and combinations of these relevant for understanding hunter-gatherer niche construction activities in pre-agricultural Europe. Our approach consists of two steps: (1) identify the possible range of hunter-gatherer impacts on landscapes based on ethnographic studies; (2) evaluate proxies possibly reflecting these impacts for both the Eemian (Last Interglacial, Middle Palaeolithic) and the Early–Middle Holocene (Mesolithic). We found these paleoenvironmental proxies were not able to unequivocally establish clear-cut differences between specific anthropogenic, climatic and megafaunal impacts for either time period in this area. We discuss case studies for both periods and show that published evidence for Mesolithic manipulation of landscapes is based on the interpretation of comparable data as available for the Last Interglacial. If one applies the ‘Mesolithic’ interpretation schemes to the Neanderthal record, three common niche construction activities can be hypothesised: vegetation burning, plant manipulation and impact on animal species presence and abundance. Our review suggests that as strong a case can be made for a Neanderthal impact on landscapes as for anthropogenic landscape changes during the Mesolithic, even though the Neanderthal evidence comes from only one high-resolution site complex. Further research should include attempts (e.g. by means of modelling studies) to establish whether hunter-gatherer impact on landscapes played out at a local level only versus at a larger scale during both time periods, while we also need to obtain comparative data on the population sizes of Last Interglacial and Holocene hunter-gatherers, as these are usually inferred to have differed significantly.
Published: 2022
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16. Litter Decomposition as an Indicator of Stream Ecosystem Functioning at Local-to-Continental Scales

Author: Chauvet, Eric, Ferreira, Verónica, Giller, Paul S., McKie, Brendan G., Tiegs, Scott D., Woodward, Guy, Elosegi, Arturo, Dobson, Michael, Fleituch, Tadeusz, Graça, Manuel A. S., Gulis, Vladislav, Hladyz, Sally, Lacoursiere, Jean O., Lecerf, Antoine, Pozo, Jesús, Preda, Elena, Riipinen, Miira P., Risnoveanu, Geta, Vadineanu, Angheluta, Vought, Lena B.-M., Gessner, Mark O., Centre National de la Recherche Scientifique - CNRS (FRANCE), Universidade de Coimbra (PORTUGAL), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Polish Academy of Sciences (POLAND), Technische Universität Berlin - TU Berlin (GERMANY), University College Cork (IRELAND), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Universidad del País Vasco - Euskal Herriko Unibertsitatea - EHU (SPAIN), University of Bucharest (ROMANIA), Coastal Carolina University - CCU (USA), Edinburgh Technopole (UNITED KINGDOM), Imperial College London (UNITED KINGDOM), Kristianstad University College - HKR (SWEDEN), Leibniz-Institute of Freshwater Ecology and Inland Fisheries - IGB (GERMANY), Monash University (AUSTRALIA), Oakland University (USA), Plymouth University (UNITED KINGDOM), Sveriges lantbruksuniversitet - SLU (SWEDEN), Laboratoire Ecologie Fonctionnelle et Environnement (LEFE), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Swedish University of Agricultural Sciences (SLU), Oakland University (UNITED STATES), Imperial College London, Coastal Carolina University - CCU (UNITED STATES), and Plymouth University
Subjects: River, Biodiversité et Ecologie, Ecosystem functioning, Stream, Riparian forest, Biodiversity, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Functional assessment, Leaf litter decomposition, Nutrient, Management
Abstract: International audience; RivFunction is a pan-European initiative that started in 2002 and was aimed at esta- blishing a novel functional-based approach to assessing the ecological status of rivers. Litter decomposition was chosen as the focal process because it plays a central role in stream ecosystems and is easy to study in the field. Impacts of two stressors that occur across the continent, nutrient pollution and modified riparian vegetation, were exam- ined at >200 paired sites in nine European ecoregions. In response to the former, decomposition was dramatically slowed at both extremes of a 1000-fold nutrient gra- dient, indicating nutrient limitation in unpolluted sites, highly variable responses across Europe in moderately impacted streams, and inhibition via associated toxic and addi- tional stressors in highly polluted streams. Riparian forest modification by clear cutting or replacement of natural vegetation by plantations (e.g. conifers, eucalyptus) or pasture produced similarly complex responses. Clear effects caused by specific riparian distur- bances were observed in regionally focused studies, but general trends across different types of riparian modifications were not apparent, in part possibly because of important indirect effects. Complementary field and laboratory experiments were undertaken to tease apart the mechanistic drivers of the continental scale field bioassays by addressing the influence of litter, fungal and detritivore diversity. These revealed generally weak and context-dependent effects on decomposition, suggesting high levels of redundancy (and hence potential insurance mechanisms that can mitigate a degree of species loss) within the food web. Reduced species richness consistently increased decomposition variability, if not the absolute rate. Further field studies were aimed at identifying impor- tant sources of this variability (e.g. litter quality, temporal variability) to help constrain ranges of predicted decomposition rates in different field situations. Thus, although many details still need to be resolved, litter decomposition holds considerable potential in some circumstances to capture impairment of stream ecosystem functioning. For instance, species traits associated with the body size and metabolic capacity of the con- sumers were often the main driver at local scales, and these were often translated into important determinants of otherwise apparently contingent effects at larger scales. Key insights gained from conducting continental scale studies included resolving the appar- ent paradox of inconsistent relationships between nutrients and decomposition rates, as the full complex multidimensional picture emerged from the large-scale dataset, of which only seemingly contradictory fragments had been seen previously.
Published: 2016
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17. A new trend for knowledge-based decision support systems design

Author: Shaofeng Liu, Pascale Zaraté, Argumentation, Décision, Raisonnement, Incertitude et Apprentissage (IRIT-ADRIA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Plymouth University, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), Plymouth University (UNITED KINGDOM), and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Subjects: Underpinning, Service (systems architecture), Decision support system, Information Systems and Management, Knowledge management, Knowledge representation and reasoning, Computer science, Strategy and Management, Inference, 02 engineering and technology, Decision support systems, application domains, Knowledge modelling and representation, [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL], [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], Intelligent DSS, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], 020204 information systems, Management of Technology and Innovation, 0202 electrical engineering, electronic engineering, information engineering, service systems, H- INFORMATIQUE, Tertiary sector of the economy, Knowledge-based decision support systems, DSS, Logique en informatique, business.industry, Knowledge economy, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], Informatique et langage, KBDSS, Intelligence artificielle, Apprentissage, Computer Science Applications, Systems design, 020201 artificial intelligence & image processing, business, Reasoning and inference
Abstract: International audience; Knowledge-based decision support systems (KBDSS) have evolved greatly over the last few decades. The key technologies underpinning the development of KBDSS can be classified into three categories: technologies for knowledge modelling and representation, technologies for reasoning and inference and web-based technologies. In the meantime, service systems have emerged and become increasingly important to value adding activities in the current knowledge economy. This paper provides a review on the recent advances in the three types of technologies, as well as the main application domains of KBDSS as service systems. Based on the examination of literature, future research directions are recommended for the development of KBDSS in general and in particular to support decision-making in service industry.
Published: 2016
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18. Testing the Effect of Relative Pollen Productivity on the REVEALS Model: A Validated Reconstruction of Europe-Wide Holocene Vegetation

Author: M. Serge, F. Mazier, R. Fyfe, M.-J. Gaillard, T. Klein, A. Lagnoux, D. Galop, E. Githumbi, M. Mindrescu, A. Nielsen, A.-K. Trondman, A. Poska, S. Sugita, J. Woodbridge, D. Abel-Schaad, C. Åkesson, T. Alenius, B. Ammann, S. Andersen, R. Anderson, M. Andrič, L. Balakauskas, L. Barnekow, V. Batalova, J. Bergman, H. Birks, L. Björkman, A. Bjune, O. Borisova, N. Broothaerts, J. Carrion, C. Caseldine, J. Christiansen, Q. Cui, A. Currás, S. Czerwiński, R. David, A. Davies, R. De Jong, F. Di Rita, B. Dietre, W. Dörfler, E. Doyen, K. Edwards, A. Ejarque, E. Endtmann, D. Etienne, E. Faure, I. Feeser, A. Feurdean, E. Fischer, W. Fletcher, F. Franco-Múgica, E. Fredh, C. Froyd, S. Garcés-Pastor, I. García-Moreiras, E. Gauthier, G. Gil-Romera, P. González-Sampériz, M. Grant, R. Grindean, J. Haas, G. Hannon, A.-J. Heather, M. Heikkilä, K. Hjelle, S. Jahns, N. Jasiunas, G. Jiménez-Moreno, I. Jouffroy-Bapicot, M. Kabailienė, I. Kamerling, M. Kangur, M. Karpińska-Kołaczek, A. Kasianova, P. Kołaczek, P. Lagerås, M. Latalowa, J. Lechterbeck, C. Leroyer, M. Leydet, M. Lindbladh, O. Lisitsyna, J.-A. López-Sáez, John Lowe, R. Luelmo-Lautenschlaeger, E. Lukanina, L. Macijauskaitė, D. Magri, D. Marguerie, L. Marquer, A. Martinez-Cortizas, I. Mehl, J. Mesa-Fernández, T. Mighall, A. Miola, Y. Miras, C. Morales-Molino, A. Mrotzek, C. Sobrino, B. Odgaard, I. Ozola, S. Pérez-Díaz, R. Pérez-Obiol, C. Poggi, P. Rego, M. Ramos-Román, P. Rasmussen, M. Reille, M. Rösch, P. Ruffaldi, M. Goni, N. Savukynienė, T. Schröder, M. Schult, U. Segerström, H. Seppä, G. Vives, L. Shumilovskikh, H. Smettan, M. Stancikaite, A. Stevenson, N. Stivrins, I. Tantau, M. Theuerkauf, S. Tonkov, W. van der Knaap, J. van Leeuwen, E. Vecmane, G. Verstraeten, S. Veski, R. Voigt, H. Von Stedingk, M. Waller, J. Wiethold, K. Willis, S. Wolters, V. Zernitskaya, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Plymouth University, Linnaeus University, Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Biology and Environmental Science, Linnaeus University, Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund], Department of Geography, Stefan cel Mare University of Suceava, Suceava 720229, Romania, Department of Geology, Lund University, 22100 Lund, Sweden, School of natural sciences, Linnaeus University, Institute of Geology at Tallinn, Tallinn University of Technology (TTÜ), Planetary Exploration Research Center [Chiba] (PERC), Chiba Institute of Technology (CIT), School of Geography, Earth and Environmental Sciences, University of Plymouth, PL4 8AA Plymouth, United Kingdom, Universidad de Granada = University of Granada (UGR), University of Turku, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Oeschger Centre for Climate Change Research (OCCR), University of Bern, Institute of Plant Sciences, Norwegian Institute for Water Research (NIVA), School of Earth & Sustainability, Northern Arizona University, Flagstaff, AZ 86011, USA, Scientific Research Centre of the Slovenian Academy of Sciences and Arts (ZRC SAZU), Department of Geology and Mineralogy [Vilnius], Vilnius University [Vilnius], Department of Palynology and Climate Dynamics, Albrecht-von-Haller-Institute for Plant Sciences, Georg-August-University of Göttingen, Institutet fur rymdfysik (IRFU), Department of Biological Sciences, Bjerknes Centre for Climate Research, University of Bergen, 7803 Bergen, Norway, Viscum Pollenanalys & Miljöhistoria, Nässjö, Sweden, Department of Biological Sciences [Bergen] (BIO / UiB), University of Bergen (UiB), Bjerknes Centre for Climate Research (BCCR), University of Bergen (UiB)-University of Bergen (UiB), Institute of Geography of RAS, Russian Academy of Sciences [Moscow] (RAS), Division of Geography and Tourism, Department of Earth and Environmental Sciences, Celestijnenlaan 200E, Heverlee, B-3001 KU Leuven, Belgium, Génie instrumental qualité alimentaire (UR GIMO), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), College of Life and Environmental Sciences, Georg-August-University = Georg-August-Universität Göttingen, University of Wisconsin-Madison, Instituto de Ciencias del Patrimonio, Consejo Superior de Investigaciones Cientificas (Incipit-CSIC), Adam Mickiewicz University in Poznań (UAM), Centre de Recherche en Archéologie, Archéosciences, Histoire (CReAAH), Le Mans Université (UM)-Université de Rennes (UR)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Nantes Université - UFR Histoire, Histoire de l'Art et Archéologie (Nantes Univ - UFR HHAA), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Kingston University [London], Geobiosphere Science Centre, Leopold Franzens Universität Innsbruck - University of Innsbruck, Institut für Ur- und Frühgeschichte, Christian-Albrechts-Universität zu Kiel (CAU), Bureau d’étude spécialisé en reconstitution des paléoenvironnements à partir de vestiges botaniques (Paleobotalab), Department of physical chemistry, Uppsala University, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Landesamt für Geologie und Bergwesen Sachsen-Anhalt, Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre Léon Bérard [Lyon], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut fûr Ur- und Frühgeschichte, Senckenberg biodiversität und klima forschungszentrum (BIK-F), Forschungsinstitut Senckenberg (SGN), Institute for Atmospheric and Climate Science [Zürich] (IAC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), University of Manchester [Manchester], The Arctic University of Norway [Tromsø, Norway] (UiT), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Institut national de recherches archéologiques préventives (Inrap), Archéologie, Terre, Histoire, Sociétés [Dijon] (ARTeHiS), Ministère de la Culture et de la Communication (MCC)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Niedersächsisches Institut für Historische Küstenforschung (NIHK), This research was funded by the TERRANOVA Project, H2020 Marie Sklodowska-Curie grant agreement no. 813904., European Project: 813904], Department of Cultures, Helsinki Collegium for Advanced Studies, Ecosystems and Environment Research Programme, University of Helsinki, Geology (-2014), Department of Forest Sciences, Department of Geosciences and Geography, Doctoral Programme in Geosciences, Yu, Le, University of St Andrews. School of Geography & Sustainable Development, University of St Andrews. Centre for Energy Ethics, University of St Andrews. Geographies of Sustainability, Society, Inequalities and Possibilities, and University of St Andrews. Environmental Change Research Group
Subjects: Europe, quantitative past land cover, Holocene, pollen data, REVEALS model, relative pollen productivity, validation, QK Botany, Validation, SDG 15 - Life on Land, Nature and Landscape Conservation, MCC, GB, Global and Planetary Change, Ecology, Humaniora: 000::Arkeologi: 090 [VDP], QK, DAS, Quantitative past land cover, GB Physical geography, 1181 Ecology, evolutionary biology, [SDE]Environmental Sciences, Pollen data, Relative pollen productivity
Abstract: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/land12050986/s1. File S1 Glossary of abbreviations used in the paper., This research was funded by the TERRANOVA Project, H2020 Marie Sklodowska-Curie grant agreement no. 813904., Reliable quantitative vegetation reconstructions for Europe during the Holocene are crucial to improving our understanding of landscape dynamics, making it possible to assess the past effects of environmental variables and land-use change on ecosystems and biodiversity, and mitigating their effects in the future. We present here the most spatially extensive and temporally continuous pollen-based reconstructions of plant cover in Europe (at a spatial resolution of 1° × 1°) over the Holocene (last 11.7 ka BP) using the ‘Regional Estimates of VEgetation Abundance from Large Sites’ (REVEALS) model. This study has three main aims. First, to present the most accurate and reliable generation of REVEALS reconstructions across Europe so far. This has been achieved by including a larger number of pollen records compared to former analyses, in particular from the Mediterranean area. Second, to discuss methodological issues in the quantification of past land cover by using alternative datasets of relative pollen productivities (RPPs), one of the key input parameters of REVEALS, to test model sensitivity. Finally, to validate our reconstructions with the global forest change dataset. The results suggest that the RPPs.st1 (31 taxa) dataset is best suited to producing regional vegetation cover estimates for Europe. These reconstructions offer a long-term perspective providing unique possibilities to explore spatial-temporal changes in past land cover and biodiversity., H2020 Marie Sklodowska-Curie TERRANOVA Project 813904, Swiss National Science Foundation, Swiss Academy of Sciences, U.S. National Science Foundation, Chinese Academy of Science, Linnaeus University’s, MERGE PRG323, ETF PRG323
Published: 2023
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19. The Role of Decision Making in the Big Data Era

Author: Dargam, Fatima, Zaraté, Pascale, Ribeiro, Rita, Liu, Shaofeng, SimTech Simulation Technology (AUSTRIA), Argumentation, Décision, Raisonnement, Incertitude et Apprentissage (IRIT-ADRIA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, CA3, Uninova, Campus New University of Lisbon/FC, Plymouth University, Grélaud, Françoise, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Université Toulouse - Jean Jaurès - UT2J (FRANCE), Université Toulouse 1 Capitole - UT1 (FRANCE), Graz University of Technology - TU Graz (AUSTRIA), Plymouth University (UNITED KINGDOM), Institut de Recherche en Informatique de Toulouse - IRIT (Toulouse, France), Computational Intelligence Research Group (CA3), Centre of Technology and Systems (CTS), Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), IRIT : Institut de Recherche Informatique de Toulouse, and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Subjects: Big data, Analytics, Internet of things, [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB], Internet of Things, Base de données, [INFO]Computer Science [cs], [INFO] Computer Science [cs], Decision support systems, H- INFORMATIQUE, Decision making, DSS
Abstract: We current live in an era, in which data heavily, constantly, and globally flows into all areas of our activities. This mobile world based on the Internet of Things and the concepts of Web 2.0, 3.0 and 4.0, connects us at anytime with our conveniences and contacts, keeps our appointments up-to-date, feeds our information needs, influences our moods, guides our shopping tendencies, and informs us about businesses and opportunities in a way that most of the times it is difficult to manage, due to the massive amount of data involved. Time has come that individuals and mainly organizations have to tackle the problem of how to process large amounts of data in support of their respective needs and operations, aiming at improving their handling and response efficiency. Big Data gives birth to an era, which cannot count anymore with classical database tools to manage and analyze information data-sets. New methods and technologies are required to enable the decision maker to understand and examine the massive, multi-dimensional, multi-source, time varying information stream to make effective decisions, sometimes in time-critical situations. In this work the authors discuss the importance of having appropriate technologies for Decision Making and Decision Support Systems to exploit the potentiality of Big Data analysis, so that organizations can improve their productivity to face increased competition in this new Big Data-Driven Decision-Making era. The study behind this paper also addresses the problem of the current widespread data-centrism tendency for almost all applications requiring decision support, since not all of them have the answers to their problems based only on data.
Published: 2015

20. Pollen-based quantitative reconstructions of Holocene regional vegetation cover (plant-functional types and land-cover types) in Europe suitable for climate modelling

Author: Małgorzata Latałowa, Thomas Giesecke, Matts Lindbladh, B. van Geel, Marie-José Gaillard, P. van der Knaap, Shinya Sugita, Chris Caseldine, Walter Dörfler, Chantal Leroyer, Jutta Lechterbeck, Mihkel Kangur, Siim Veski, Anneli Poska, Per Lagerås, Laurent Marquer, Anna-Kari Trondman, Ralph Fyfe, Philip Barratt, Florence Mazier, Manfred Rösch, Tiiu Koff, E. Fischer, Tove Hultberg, Thomas Persson, Bent Vad Odgaard, Michelle Leydet, Anna Broström, Petr Kuneš, Heikki Seppä, Harry John Betteley Birks, John Dodson, Anne Birgitte Nielsen, Fraser J.G. Mitchell, Lucia Wick, Laimdota Kalnina, Leif Björkman, Claire L. Twiddle, S. M. Peglar, Rémi David, Anne E. Bjune, Department of Biology and Environmental Science, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Institute of Ecology, Tallinn University-Tallinn University, School of Geography, Plymouth University-Plymouth University, Department of Geology, Lund University [Lund], Northern Rivers Institute, School of Geosciences, University of Aberdeen, Queen's University [Belfast] (QUB), Department of Biology and Bjerkness Centre for Climate Research, Uni Research Climate, Uni Research Ltd, Bjerknes Centre for Climate Research (BCCR), Department of Biological Sciences [Bergen] (BIO / UiB), University of Bergen (UiB)-University of Bergen (UiB), Viscum pollenanalys and miljohistoria, Viscum pollenanalys and miljohistoria-Viscum pollenanalys and miljohistoria, Department of Geology, Quaternary Sciences, College of Life and Environmental Sciences, Centre de Recherche en Archéologie, Archéosciences, Histoire (CReAAH), Université de Nantes (UN)-Le Mans Université (UM)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Institute for Environmental Research, Australian Nuclear Science and Technology Organisation, Institute fur Ur und fruhgeschichte, Department of Paleoecology and landscape Ecology, Department of Palynology and Climate Dynamics, Georg-August-University [Göttingen]-Georg-August-University [Göttingen], Southern Swedish Forest Research Centre, Swedish University of Agricultural Sciences (SLU), Faculty of Geography and Earth Sciences [Riga], University of Latvia (LU), Institute of Plant Sciences, Department of Botany, Faculty of Science, Swedish National Heritage Board, Laboratory of Palaeoecology and Archaeology, University of Gdańsk (UG)-University of Gdańsk (UG), State Office for cultural Heritage Baden-Wuerttemberg, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Botany Department, Trinity College Dublin (TCD), Trinity College Dublin, Department of Geoscience [Aarhus], Aarhus University [Aarhus], Department of Physical Geography and Ecosystem Science [Lund], P.O. Box 64, Institute of Geology, Tallinn University of Technology (TTÜ), University of Basel (Unibas), VR 349-2007-8705, Swedish [VR] Research Council, Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Nantes Université (NU)-Ministère de la Culture (MC)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Le Mans Université (UM), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Le Mans Université (UM)-Université de Rennes (UR)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR Histoire, Histoire de l'Art et Archéologie (UFR HHAA), Université de Nantes (UN)-Université de Nantes (UN)-Ministère de la Culture (MC), Georg-August-University = Georg-August-Universität Göttingen-Georg-August-University = Georg-August-Universität Göttingen, Charles University [Prague] (CU), Paleoecology and Landscape Ecology (IBED, FNWI), Department of Geosciences and Geography, Université de Nantes - UFR Histoire, Histoire de l'Art et Archéologie (UFR HHAA), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Université de Rennes 2 (UR2), and Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU)
Subjects: DYNAMICS, Climate Change, Biodiversity, SOURCE AREA, Land cover, 580 Plants (Botany), medicine.disease_cause, 114 Physical sciences, pollen data, FUTURE, Deforestation, Pollen, medicine, Environmental Chemistry, ALGORITHM, 1172 Environmental sciences, Holocene, ComputingMilieux_MISCELLANEOUS, General Environmental Science, Global and Planetary Change, Ecology, REVEALS model, OPENNESS, Plant Dispersal, QUATERNARY PALYNOLOGICAL DATABASE, SOUTHERN SWEDEN, Vegetation, [SHS.GEO]Humanities and Social Sciences/Geography, Models, Theoretical, 15. Life on land, Evergreen, quantitative past land cover, TERRESTRIAL ECOSYSTEMS, Europe, Deciduous, Matematikk og naturvitenskap: 400 [VDP], Mathematics and natural scienses: 400 [VDP], 13. Climate action, 1181 Ecology, evolutionary biology, plant-functional types, REVEALS-MODEL, CARBON-CYCLE
Abstract: A contribution to the PAGES Focus 4 Land Use and Cover Theme ABSTRACT: We present quantitative reconstructions of regional vegetation cover in north western Europe western Europe north of the Alps and eastern Europe for five time windows in the Holocene [around 6k 3k 0.5k 0.2k and 0.05k calendar years before present (bp)] at a 1° × 1° spatial scale with the objective of producing vegetation descriptions suitable for climate modelling. The REVEALS model was applied on 636 pollen records from lakes and bogs to reconstruct the past cover of 25 plant taxa grouped into 10 plant functional types and three land cover types [evergreen trees summer green (deciduous) trees and open land]. The model corrects for some of the biases in pollen percentages by using pollen productivity estimates and fall speeds of pollen and by applying simple but robust models of pollen dispersal and deposition. The emerging patterns of tree migration and deforestation between 6k bp and modern time in the REVEALS estimates agree with our general understanding of the vegetation history of Europe based on pollen percentages. However the degree of anthropogenic deforestation (i.e. cover of cultivated and grazing land) at 3k 0.5k and 0.2k bp is significantly higher than deduced from pollen percentages. This is also the case at 6k in some parts of Europe in particular Britain and Ireland. Furthermore the relationship between summer green and evergreen trees and between individual tree taxa differs significantly when expressed as pollen percentages or as REVEALS estimates of tree cover. For instance when Pinus is dominant over Picea as pollen percentages Picea is dominant over Pinus as REVEALS estimates. These differences play a major role in the reconstruction of European landscapes and for the study of land cover–climate interactions biodiversity and human resources.
Published: 2015
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21. On the dynamics of the adenylate energy system: homeorhesis vs homeostasis

Author: Jesus M. Cortes, Mathieu Desroches, Luis Martínez, Serafim Rodrigues, Edelmira Valero, Iker Malaina, Ildefonso M. De la Fuente, University of the Basque Country [Bizkaia] ( UPV/EHU ), BioCruces Research Institute, University of the Basque Country [Bizkaia] ( UPV/EHU ) -Cruces University Hospital, IKERBASQUE, IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain, University of Castilla-La Mancha ( UCLM ), Multiscale dYnamiCs in neuroENdocrine AxEs ( Mycenae ), Inria Paris-Rocquencourt, Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Plymouth University, U.K., University of the Basque Country [Bizkaia] (UPV/EHU), University of the Basque Country [Bizkaia] (UPV/EHU)-Hospital Universitario Cruces = Cruces University Hospital, University of Castilla-La Mancha (UCLM), Multiscale dYnamiCs in neuroENdocrine AxEs (Mycenae), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Plymouth University, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU)-Hospital Universitario Cruces = Cruces University Hospital, Ikerbasque - Basque Foundation for Science, and Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM)
Subjects: Periodicity, Bioenergetics, BIOCHEMISTRY AND MOLECULAR BIOLOGY, Biochemistry, Systems Science, chemistry.chemical_compound, 0302 clinical medicine, Adenosine Triphosphate, Adenine nucleotide, physarum polycephalum, Homeostasis, Energy charge, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Multidisciplinary, pancreatic beta-cell, yeast sacchcromyces-cerevisiae, Adenosine Diphosphate, AGRICULTURAL AND BIOLOGICAL SCIENCES, [ SCCO.NEUR ] Cognitive science/Neuroscience, Physical Sciences, Research Article, Adenosine monophosphate, Computer and Information Sciences, Science, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], [ MATH.MATH-DS ] Mathematics [math]/Dynamical Systems [math.DS], Adenylate kinase, Biology, cellular metabolic structure, Models, Biological, 03 medical and health sciences, Animals, Humans, Computer Simulation, 030304 developmental biology, long-range correlations, Homeorhesis, MEDICINE, [SCCO.NEUR]Cognitive science/Neuroscience, intracellular ATP concentration, Biology and Life Sciences, tobacco BY-2 cells, Adenosine Monophosphate, Adenosine diphosphate, Kinetics, Metabolism, chemistry, Nonlinear Dynamics, Biophysics, escherichia-coli, biochemical oscillations, Energy Metabolism, Adenosine triphosphate, adenine-nucleotide concentrations, 030217 neurology & neurosurgery, Mathematics
Abstract: Biochemical energy is the fundamental element that maintains both the adequate turnover of the biomolecular structures and the functional metabolic viability of unicellular organisms. The levels of ATP, ADP and AMP reflect roughly the energetic status of the cell, and a precise ratio relating them was proposed by Atkinson as the adenylate energy charge (AEC). Under growth-phase conditions, cells maintain the AEC within narrow physiological values, despite extremely large fluctuations in the adenine nucleotides concentration. Intensive experimental studies have shown that these AEC values are preserved in a wide variety of organisms, both eukaryotes and prokaryotes. Here, to understand some of the functional elements involved in the cellular energy status, we present a computational model conformed by some key essential parts of the adenylate energy system. Specifically, we have considered (I) the main synthesis process of ATP from ADP, (II) the main catalyzed phosphotransfer reaction for interconversion of ATP, ADP and AMP, (III) the enzymatic hydrolysis of ATP yielding ADP, and (IV) the enzymatic hydrolysis of ATP providing AMP. This leads to a dynamic metabolic model (with the form of a delayed differential system) in which the enzymatic rate equations and all the physiological kinetic parameters have been explicitly considered and experimentally tested in vitro. Our central hypothesis is that cells are characterized by changing energy dynamics (homeorhesis). The results show that the AEC presents stable transitions between steady states and periodic oscillations and, in agreement with experimental data these oscillations range within the narrow AEC window. Furthermore, the model shows sustained oscillations in the Gibbs free energy and in the total nucleotide pool. The present study provides a step forward towards the understanding of the fundamental principles and quantitative laws governing the adenylate energy system, which is a fundamental element for unveiling the dynamics of cellular life.
Published: 2014
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22. Creating spatially continuous maps of past land cover from point estimates: A new statistical approach applied to pollen data

Author: Benjamin Smith, Johan Lindström, Anne E. Bjune, Shinya Sugita, Anne Birgitte Nielsen, Anneli Poska, Małgorzata Latałowa, Thomas Giesecke, Ralph Fyfe, Jed O. Kaplan, Marie-José Gaillard, Anna-Kari Trondman, Mikhel Kangur, H. John B. Birks, Laurent Marquer, Florence Mazier, Behnaz Pirzamanbein, Mathematical Statistics, Centre for Mathematical Sciences, Lund University [Lund], Department of Physical Geography and Ecosystem Science [Lund], Institute of Ecology, Tallinn University-Tallinn University, Department of Biology and Environmental Science, School of Geography, Plymouth University-Plymouth University, Géographie de l'environnement (GEODE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Department of Geology, Institute for Environmental Sciences [Geneva] (ISE), University of Geneva [Switzerland], Department of Biology and Bjerkness Centre for Climate Research, Department of Biological Sciences [Bergen] (BIO / UiB), University of Bergen (UiB), Department of Palynology and Climate Dynamics, Georg-August-University [Göttingen]-Georg-August-University [Göttingen], and Laboratory of palaecology and archeobotany
Subjects: Land cover, Deviance (statistics), Information Criteria, Compositional data, Gaussian Markov random fields, spatial modeling, Point estimation, Probability Theory and Statistics, Ecology, Evolution, Behavior and Systematics, Ecology, Gaussian Markov randaom fields, Ecological Modeling, Statistical model, Vegetation, palaecology, [SHS.GEO]Humanities and Social Sciences/Geography, 15. Life on land, Spatial modeling, compositional data, 13. Climate action, pollen, Paleoecology, Pollen, Environmental science, Physical geography, Earth and Related Environmental Sciences
Abstract: Reliable estimates of past land cover are critical for assessing potential effects of anthropogenic land-cover changes on past earth surface-climate feedbacks and landscape complexity. Fossil pollen records from lakes and bogs have provided important information on past natural and human-induced vegetation cover. However, those records provide only point estimates of past land cover, and not the spatially continuous maps at regional and sub-continental scales needed for climate modelling. We propose a set of statistical models that create spatially continuous maps of past land cover by combining two data sets: 1) pollen-based point estimates of past land cover (from the REVEALS model) and 2) spatially continuous estimates of past land cover, obtained by combining simulated potential vegetation (from LPJ-GUESS) with an anthropogenic land-cover change scenario (KK10). The proposed models rely on statistical methodology for compositional data and use Gaussian Markov Random Fields to model spatial dependencies in the data. Land-cover reconstructions are presented for three time windows in Europe: 0.05, 0.2, and 6 ka years before present (BP). The models are evaluated through cross-validation, deviance information criteria and by comparing the reconstruction of the 0.05 ka time window to the present-day land-cover data compiled by the European Forest Institute (EFI). For 0.05 ka, the proposed models provide reconstructions that are closer to the EFI data than either the REVEALS- or LPJ-GUESS/KK10-based estimates; thus the statistical combination of the two estimates improves the reconstruction. The reconstruction by the proposed models for 0.2 ka is also good. For 6 ka, however, the large differences between the REVEALS- and LPJ-GUESS/KK10-based estimates reduce the reliability of the proposed models. Possible reasons for the increased differences between REVEALS and LPJ-GUESS/KK10 for older time periods and further improvement of the proposed models are discussed.
Published: 2014
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23. Holocene changes in vegetation composition in northern Europe: why quantitative pollen-based vegetation reconstructions matter

Author: Anneli Poska, Anna-Kari Trondman, Jörg Christiansen, Mihkel Kangur, Bent Vad Odgaard, Manuela Schult, Ulrike Herzschuh, Marie-José Gaillard, Ralph Fyfe, Anne Birgitte Nielsen, H. John B. Birks, Kevin J. Edwards, Sebastian Lorenz, Thomas Giesecke, Shinya Sugita, Teija Alenius, Heikki Seppä, John Dodson, Anne E. Bjune, Laurent Marquer, Florence Mazier, Department of Biology and Environmental Science, Institute of Ecology, Tallinn University-Tallinn University, Géographie de l'environnement (GEODE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Department of Geology, Lund University, Sölvegatan 12, SE-22362 Lund, Sweden, School of Geography, Plymouth University-Plymouth University, Institute of Geosciences, Aarthus University, Department of Philosophy, History, Culture and Art Studies, Department of Biology and Bjerkness Centre for Climate Research, Department of Palynology and Climate Dynamics, Georg-August-University [Göttingen]-Georg-August-University [Göttingen], Institute for Environmental Research, Australian Nuclear Science and Technology Organisation, Departments of Geography and Environmental and Archaeology, School of Geosciences, Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), Department of geography and Geology, Ernst Moritz Amdt University, Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund], Department of Geosciences and Geography [Helsinki], Falculty of Science [Helsinki], and University of Helsinki-University of Helsinki
Subjects: 010506 paleontology, Archeology, 010504 meteorology & atmospheric sciences, Biome, Biodiversity, Northern Europe, medicine.disease_cause, 01 natural sciences, Diversity index, Abundance (ecology), Pollen, medicine, ta615, Ecology, Evolution, Behavior and Systematics, Holocene, 0105 earth and related environmental sciences, Quantitative regional plant abundance Rate of compositional change, Global and Planetary Change, Ecology, Geology, Human impact, Vegetation, [SHS.GEO]Humanities and Social Sciences/Geography, 15. Life on land, REVEALS (Regional Estimates of VEgetation Abundance from Large Sites) model Vegetation diversity indices, 13. Climate action, [SDE]Environmental Sciences, Species evenness, Institut für Geowissenschaften
Abstract: We present pollen-based reconstructions of the spatio-temporal dynamics of northern European regional vegetation abundance through the Holocene. We apply the Regional Estimates of VEgetation Abundance from Large Sites (REVEALS) model using fossil pollen records from eighteen sites within five modern biomes in the region. The eighteen sites are classified into four time-trajectory types on the basis of principal components analysis of both the REVEALS-based vegetation estimates (RVs) and the pollen percentage (PPs). The four trajectory types are more clearly separated for RVs than PPs. Further, the timing of major Holocene shifts, rates of compositional change, and diversity indices (turnover and evenness) differ between RVs and PPs. The differences are due to the reduction by REVEALS of biases in fossil pollen assemblages caused by different basin size, and inter-taxonomic differences in pollen productivity and dispersal properties. For example, in comparison to the PPs, the RVs show an earlier increase in Corylus and Ulmus in the early-Holocene and a more pronounced increase in grassland and deforested areas since the mid-Holocene. The results suggest that the influence of deforestation and agricultural activities on plant composition and abundance from Neolithic times was stronger than previously inferred from PPs. Relative to PPs, RVs show a more rapid compositional change, a largest decrease in turnover, and less variable evenness in most of northern Europe since 5200 cal yr BP. All these changes are primarily related to the strong impact of human activities on the vegetation. This study demonstrates that RV-based estimates of diversity indices, timing of shifts, and rates of change in reconstructed vegetation provide new insights into the timing and magnitude of major human distribution on Holocene regional, vegetation, feature that are critical in the assessment of human impact on vegetation, land-cover, biodiversity, and climate in the past. (C) Elsevier Ltd.All tights reserved.
Published: 2014
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24. O denerwującej niemożliwości inkluzywnej architektury

Author: Nawratek, Krzysztof, School of Architecture, Design and Environment Plymouth University, UK, and Dr Krzysztof Nawratek – dyrektor studiów magisterskich w szkole architektury w Plymouth University (UK), teoretyk miasta, autor książek Ideologie w przestrzeni. Próby demistyfikacji (Kraków 2005), Miasto jako idea polityczna (Kraków 2008, wydanie angielskie Plymouth 2011), Dziury w całym. Wstęp do miejskich rewolucji (Warszawa 2012, wydanie angielskie Washington 2012). W przygotowaniu Re-industrialisation and progressive urbanism (Nowy Jork 2015), [Architecture and Urbanism of] Radical Inclusivity (Plymouth 2015) oraz Autonomia, terytorium i ekonomia mocy. Studia nad miastem po-kapitalistycznym (Warszawa 2015).
Subjects: postmodernizm, Theilard de Chardin, Orygenes, Solieri, architektura
Abstract: Artykuł rozważa możliwość i warunki zaistnienia architektury i przestrzeni inkluzywnej, reinterpretując i „uprzestrzenniając” idee powszechnego zbawienia (Orygenes) oraz punktu Omega (Theilard de Chardin, w interpretacji Paolo Solierego). Powołując się na chrześcijański „problem piekła” jako przestrzeni z definicji ekskluzywnej, artykuł konstruuje model architektury, która ów ekskluzywizm przezwycięża. Artykuł przywołuje przykłady zrealizowanych obiektów oraz elementy postmodernistycznych teorii architektonicznych, by pokazać możliwość dalszego rozwoju architektury poza obecnie obowiązujący paradygmat autonomicznego obiektu o zdefiniowanych funkcjach.
Published: 2014

25. The European Modern Pollen Database (EMPD) project

Author: Basil A. S. Davis, Marco Zanon, Pamella Collins, Achille Mauri, Johan Bakker, Doris Barboni, Alexandra Barthelmes, Celia Beaudouin, Anne E. Bjune, Elissaveta Bozilova, Richard H. W. Bradshaw, Barbara A. Brayshay, Simon Brewer, Elisabetta Brugiapaglia, Jane Bunting, Simon E. Connor, Jacques-Louis de Beaulieu, Kevin Edwards, Ana Ejarque, Patricia Fall, Assunta Florenzano, Ralph Fyfe, Didier Galop, Marco Giardini, Thomas Giesecke, Michael J. Grant, Jöel Guiot, Susanne Jahns, Vlasta Jankovská, Stephen Juggins, Marina Kahrmann, Monika Karpińska-Kołaczek, Piotr Kołaczek, Norbert Kühl, Petr Kuneš, Elena G. Lapteva, Suzanne A. G. Leroy, Michelle Leydet, José Guiot, José Antonio López Sáez, Alessia Masi, Isabelle Matthias, Florence Mazier, Vivika Meltsov, Anna Maria Mercuri, Yannick Miras, Fraser J. G. Mitchell, Jesse L. Morris, Filipa Naughton, Anne Birgitte Nielsen, Elena Novenko, Bent Odgaard, Elena Ortu, Mette Venås Overballe-Petersen, Heather S. Pardoe, Silvia M. Peglar, Irena A. Pidek, Laura Sadori, Heikki Seppä, Elena Severova, Helen Shaw, Joanna Święta-Musznicka, Martin Theuerkauf, Spassimir Tonkov, Siim Veski, W. O. van der Knaap, Jacqueline F. N. van Leeuwen, Jessie Woodbridge, Marcelina Zimny, Jed O. Kaplan, López Sáez, José Antonio, ÉcolePolytechniqueFédérale de Lausanne (EPFL), School of Architecture, Civil and Environmental, Center for Archaeological Sciences, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Dipartimento de Scienze Animali, Vegetali e dell' Ambiente, Università degli Studi del Molise = University of Molise (UNIMOL), Department of Geography, University of Hull-University of Hull, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), ICAC, Icac, Laboratorio di Palinologia e Paleobotanica, School of Geography, Plymouth University-Plymouth University, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di biologia ambientale, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Laboratoire Ecologie Fonctionnelle et Environnement (LEFE), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), López Sáez, José Antonio [0000-0002-3122-2744], Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Università del Molise, Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Università degli Studi di Roma 'La Sapienza' [Rome], Laboratoire Ecologie Fonctionnelle et Environnement (ECOLAB), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Environnements, Dynamiques et Territoires de la Montagne (EDYTEM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP)
Subjects: 010506 paleontology, Archeology, Research groups, europe, pollen, epd, empd, surface sample, database, 010504 meteorology & atmospheric sciences, Climate change, Plant Science, 580 Plants (Botany), computer.software_genre, medicine.disease_cause, 01 natural sciences, Proxy (climate), Database, Pollen, medicine, EMPD, Biogeosciences, 0105 earth and related environmental sciences, Surface sample, Surface Sample, EPD, Europe, Paleontology, 15. Life on land, Geography, European Pollen Database, [SDE]Environmental Sciences, computer
Abstract: Davis, B.A.S. et al., Modern pollen samples provide an invaluable research tool for helping to interpret the quaternary fossil pollen record, allowing investigation of the relationship between pollen as the proxy and the environmental parameters such as vegetation, land-use, and climate that the pollen proxy represents. The European Modern Pollen Database (EMPD) is a new initiative within the European Pollen Database (EPD) to establish a publicly accessible repository of modern (surface sample) pollen data. This new database will complement the EPD, which at present holds only fossil sedimentary pollen data. The EMPD is freely available online to the scientific community and currently has information on almost 5,000 pollen samples from throughout the Euro-Siberian and Mediterranean regions, contributed by over 40 individuals and research groups. Here we describe how the EMPD was constructed, the various tables and their fields, problems and errors, quality controls, and continuing efforts to improve the available data.
Published: 2013
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26. Towards mapping the late Quaternary vegetation change of Europe

Author: Giesecke, T., Davis, B., Brewer, S., Finsinger, W., Wolters, S., Blaauw, M., de Beaulieu, J.-L., Binney, H., Fyfe, R.M., Gaillard, M.-J., Gil-Romera, G., van der Knaap, W.O., Kunes, P., Kühl, N., van Leeuwen, J.F.N., Leydet, M., Lotter, A.F., Ortu, E., Semmler, M., Bradshaw, R.H.W., Coastal dynamics, Fluvial systems and Global change, Dep Biologie, Palaeo-ecologie, Department of Geography, University of Liverpool-University of Liverpool, ÉcolePolytechniqueFédérale de Lausanne (EPFL), School of Architecture, Civil and Environmental, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Queen's University [Belfast] (QUB), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Palaeoecology Laboratory, University of Southampton-University of Southampton, School of Geography, Plymouth University-Plymouth University, Department of Biology and Environmental Science, Institute of Plant Sciences, University of Bern, Environnements, Dynamiques et Territoires de la Montagne (EDYTEM), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre européen de recherche et d'enseignement de géosciences de l'environnement ( CEREGE ), Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Collège de France ( CdF ) -Institut National de la Recherche Agronomique ( INRA ) -Institut national des sciences de l'Univers ( INSU - CNRS ), Institut des Sciences de l'Evolution de Montpellier ( ISEM ), Université de Montpellier ( UM ) -Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique ( CNRS ), Queen's University [Belfast] ( QUB ), Institut Méditerranéen d'Ecologie et de Paléoécologie ( IMEP ), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Centre National de la Recherche Scientifique ( CNRS ), University of Southampton [Southampton]-University of Southampton [Southampton], University of Plymouth-University of Plymouth, Institut méditerranéen de biodiversité et d'écologie marine et continentale ( IMBE ), Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Aix Marseille Université ( AMU ) -Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique ( CNRS ), Environnements, Dynamiques et Territoires de la Montagne ( EDYTEM ), Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Coastal dynamics, Fluvial systems and Global change, Dep Biologie, and Palaeo-ecologie
Subjects: 010506 paleontology, Archeology, 010504 meteorology & atmospheric sciences, [ SDV.BV.BOT ] Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDE.MCG]Environmental Sciences/Global Changes, Climate change, Plant Science, 580 Plants (Botany), 01 natural sciences, [ SDV.SA.SF ] Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, law.invention, Paleontology, [SDV.SA.SF]Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, law, Plantago lanceolata, [ SDU.ENVI ] Sciences of the Universe [physics]/Continental interfaces, environment, Radiocarbon dating, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Holocene, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Chronology, [ SDE.BE ] Environmental Sciences/Biodiversity and Ecology, EPD, European pollen database, Age-depth relationships, Age uncertainty, Palaeontology, Earth Sciences, Biogeosciences, Climate Change, Anthropology, Archaeology, Vegetation, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDE.ES]Environmental Sciences/Environmental and Society, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [ SDE.MCG ] Environmental Sciences/Global Changes, 13. Climate action, European Pollen Database, Physical geography, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Scale (map), Quaternary, Geology, [ SDE.ES ] Environmental Sciences/Environmental and Society
Abstract: 23 páginas.- Thomas Giesecke et.al., The number of well-dated pollen diagrams in Europe has increased considerably over the last 30 years and many of them have been submitted to the European Pollen Database (EPD). This allows for the construction of increasingly precise maps of Holocene vegetation change across the continent. Chronological information in the EPD has been expressed in uncalibrated radiocarbon years, and most chronologies to date are based on this time scale. Here we present new chronologies for most of the datasets stored in the EPD based on calibrated radiocarbon years. Age information associated with pollen diagrams is often derived from the pollen stratigraphy itself or from other sedimentological information. We reviewed these chronological tie points and assigned uncertainties to them. The steps taken to generate the new chronologies are described and the rationale for a new classification system for age uncertainties is introduced. The resulting chronologies are fit for most continental-scale questions. They may not provide the best age model for particular sites, but may be viewed as general purpose chronologies. Taxonomic particularities of the data stored in the EPD are explained. An example is given of how the database can be queried to select samples with appropriate age control as well as the suitable taxonomic level to answer a specific research question. The readers are reques, We wish to thank all those who have contributed data to the EPD. Keith Bennett provided valuable comments in discussions and to the manuscript.
Published: 2013
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27. Major loss of coralline algal diversity in response to ocean acidification

Author: Marco Milazzo, Jason M. Hall-Spencer, Lucia Porzio, Viviana Peña, Ben P. Harvey, Sylvain Agostini, Paulo Antunes Horta, Line Le Gall, Universidade da Coruña, Université de Tsukuba = University of Tsukuba, Dipartimento di Scienze della Terra e del Mare [Palermo] (DiSTeM), Università degli studi di Palermo - University of Palermo, Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Plymouth University, Pena V., Harvey B.P., Agostini S., Porzio L., Milazzo M., Horta P., Le Gall L., and Hall-Spencer J.M.
Subjects: macroalgae, 0106 biological sciences, ecosystem engineers, Oceans and Seas, Biodiversity, adaptation, 010603 evolutionary biology, 01 natural sciences, Ecosystem engineer, Evolutionary history, Macroalgae, Algae, Climate change, Environmental Chemistry, Seawater, Photic zone, Ecosystem, 14. Life underwater, Adaptation, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography, biodiversity, General Environmental Science, Global and Planetary Change, Ecology, biology, 010604 marine biology & hydrobiology, Ocean chemistry, fungi, Coralline algae, Ocean acidification, Seaweeds, Hydrogen-Ion Concentration, 15. Life on land, biology.organism_classification, psbA, seaweeds, climate change, 13. Climate action, Rhodophyta, Ecosystem engineers, [SDV.EE.BIO]Life Sciences [q-bio]/Ecology, environment/Bioclimatology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, evolutionary history
Abstract: [Abstract] Calcified coralline algae are ecologically important in rocky habitats in the marine photic zone worldwide and there is growing concern that ocean acidification will severely impact them. Laboratory studies of these algae in simulated ocean acidification conditions have revealed wide variability in growth, photosynthesis and calcification responses, making it difficult to assess their future biodiversity, abundance and contribution to ecosystem function. Here, we apply molecular systematic tools to assess the impact of natural gradients in seawater carbonate chemistry on the biodiversity of coralline algae in the Mediterranean and the NW Pacific, link this to their evolutionary history and evaluate their potential future biodiversity and abundance. We found a decrease in the taxonomic diversity of coralline algae with increasing acidification with more than half of the species lost in high pCO2 conditions. Sporolithales is the oldest order (Lower Cretaceous) and diversified when ocean chemistry favoured low Mg calcite deposition; it is less diverse today and was the most sensitive to ocean acidification. Corallinales were also reduced in cover and diversity but several species survived at high pCO2; it is the most recent order of coralline algae and originated when ocean chemistry favoured aragonite and high Mg calcite deposition. The sharp decline in cover and thickness of coralline algal carbonate deposits at high pCO2 highlighted their lower fitness in response to ocean acidification. Reductions in CO2 emissions are needed to limit the risk of losing coralline algal diversity. Fieldwork in the Mediterranean was supported by the EU ‘Mediterranean Sea Acidification under a changing climate’ project (MedSeA; grant agreement 265103; MM, JH-S)
Published: 2021
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28. Novel DNM1L variants impair mitochondrial dynamics through divergent mechanisms

Author: Kelsey A Nolden, John M Egner, Jack J Collier, Oliver M Russell, Charlotte L Alston, Megan C Harwig, Michael E Widlansky, Souphatta Sasorith, Inês A Barbosa, Andrew GL Douglas, Julia Baptista, Mark Walker, Deirdre E Donnelly, Andrew A Morris, Hui Jeen Tan, Manju A Kurian, Kathleen Gorman, Santosh Mordekar, Charu Deshpande, Rajib Samanta, Robert McFarland, R Blake Hill, Robert W Taylor, Monika Oláhová, Medical College of Wisconsin [Milwaukee] (MCW), Newcastle University [Newcastle], McGill University = Université McGill [Montréal, Canada], Newcastle Upon Tyne Hospitals NHS Foundation Trust, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), King‘s College London, University Hospital Southampton NHS Foundation Trust, University of Southampton, Plymouth University, Belfast City Hospital, Manchester Centre for Genomic Medicine [Manchester, UK] (MCGM), St Mary's Hospital Manchester-Manchester Academic Health Science Centre (MAHSC), University of Manchester [Manchester]-University of Manchester [Manchester]-Manchester University NHS Foundation Trust (MFT)-Faculty of Biology, Medicine and Health [Manchester, UK], University of Manchester [Manchester], Central Manchester University Hospitals [Manchester, U.K.], University College of London [London] (UCL), Children's Health Ireland [Crumlin, Dublin, Ireland] (CHI), University College Dublin [Dublin] (UCD), Sheffield Children's NHS Foundation Trust, Guy's and St Thomas' NHS Foundation Trust [London, UK], University Hospitals Leicester, and MORNET, Dominique
Subjects: [SDV] Life Sciences [q-bio], Ecology, Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], Plant Science, Biochemistry, Genetics and Molecular Biology (miscellaneous)
Abstract: Imbalances in mitochondrial and peroxisomal dynamics are associated with a spectrum of human neurological disorders. Mitochondrial and peroxisomal fission both involve dynamin-related protein 1 (DRP1) oligomerisation and membrane constriction, although the precise biophysical mechanisms by which distinct DRP1 variants affect the assembly and activity of different DRP1 domains remains largely unexplored. We analysed four unreported de novo heterozygous variants in the dynamin-1-like geneDNM1L, affecting different highly conserved DRP1 domains, leading to developmental delay, seizures, hypotonia, and/or rare cardiac complications in infancy. Single-nucleotide DRP1 stalk domain variants were found to correlate with more severe clinical phenotypes, with in vitro recombinant human DRP1 mutants demonstrating greater impairments in protein oligomerisation, DRP1-peroxisomal recruitment, and both mitochondrial and peroxisomal hyperfusion compared to GTPase or GTPase-effector domain variants. Importantly, we identified a novel mechanism of pathogenesis, where a p.Arg710Gly variant uncouples DRP1 assembly from assembly-stimulated GTP hydrolysis, providing mechanistic insight into how assembly-state information is transmitted to the GTPase domain. Together, these data reveal that discrete, pathologicalDNM1Lvariants impair mitochondrial network maintenance by divergent mechanisms.
Published: 2022
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29. Focused wave interactions with floating structures: a blind comparative study

Author: Jun Zang, Guillaume Ducrozet, Jennifer Van Rij, Martyn Hann, Alison Williams, Harry B. Bingham, Jack Hughes, Haoyu Ding, SA Brown, Hao Chen, Shiqiang Yan, Ian Masters, Benjamin Bouscasse, Christian Windt, Pal Schmitt, Qiang Chen, Zhihua Ma, Josh Davidson, Junxian X Wang, Ling Qian, Deborah Greaves, Giuseppe Giorgi, Zhihua Xie, Qingwei Ma, Edward Ransley, Jinghua H Wang, Zaibin Lin, Yi Hsiang Yu, John V. Ringwood, Zhaobin Li, Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Plymouth University, Queen's University [Belfast] (QUB), Shanghai Mental Health Center, Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), College of Engineering [Swansea], Swansea University, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Spatio-Temporal Activity Recognition Systems (STARS), Inria Sophia Antipolis - Méditerranée (CRISAM), and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: Renewable energy, Dynamic time warping, Computer science, fluid mechanics, Hydraulics & hydrodynamics, 020101 civil engineering, 02 engineering and technology, hydraulics & hydrodynamics, 01 natural sciences, 010305 fluids & plasmas, 0201 civil engineering, 0103 physical sciences, Fluid mechanics, Cylinder, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], SDG 7 - Affordable and Clean Energy, Offshore engineering, ComputingMilieux_MISCELLANEOUS, Simulation, Civil and Structural Engineering, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Mechanics of the fluids [physics.class-ph], Numerical analysis, Linear model, Mooring, Nonlinear system, TA, Mechanics of Materials, Offshore geotechnical engineering, offshore engineering
Abstract: International audience; The paper presents results from the Collaborative Computational Project in Wave Structure Interaction (CCP-WSI) Blind Test Series 2. Without prior access to the physical data, participants, with numerical methods ranging from low-fidelity linear models to fully non-linear Navier–Stokes (NS) solvers, simulate the interaction between focused wave events and two separate, taut-moored, floating structures: a hemispherical-bottomed cylinder and a cylinder with a moonpool. The ‘blind’ numerical predictions for heave, surge, pitch and mooring load, are compared against physical measurements. Dynamic time warping is used to quantify the predictive capability of participating methods. In general, NS solvers and hybrid methods give more accurate predictions; however, heave amplitude is predicted reasonably well by all methods; and a WEC-Sim implementation, with CFD-informed viscous terms, demonstrates comparable predictive capability to even the stronger NS solvers. Large variations in the solutions are observed (even among similar methods), highlighting a need for standardisation in the numerical modelling of WSI problems.
Published: 2021
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30. The European Pollen Database: past efforts and current activities

Author: Pavel E. Tarasov, Jacques-Louis de Beaulieu, Petr Kuneš, Heather Binney, André F. Lotter, Thomas Giesecke, Walter Finsinger, Marie-José Gaillard, Eric C. Grimm, Ralph Fyfe, Norbert Kühl, Spassimir Tonkov, Anne Le Flao, Graciela Gil-Romera, Richard H. W. Bradshaw, Simon Brewer, Brian Huntley, Michelle Leydet, School of Geography, Plymouth University-Plymouth University, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Palaeoecology Laboratory, University of Southampton-University of Southampton, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Utrecht University Palaeoecology, Laboratory of Palaeobotany and Palynology (UTRECHT UNIVERSITY), Utrecht University [Utrecht], Department of Biology and Environmental Science, Department of Geography, University of Liverpool, Freie Universität Berlin, Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), and Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, 010506 paleontology, Archeology, Group method of data handling, Computer science, Earth Sciences, Archaeology, Anthropology, Climate Change, Biogeosciences, Paleontology, [SDE.MCG]Environmental Sciences/Global Changes, Climate change, Plant Science, medicine.disease_cause, 010603 evolutionary biology, 01 natural sciences, Task (project management), [SDV.SA.SF]Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, Pollen, medicine, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Pollen count, ComputingMilieux_MISCELLANEOUS, database, 0105 earth and related environmental sciences, Palynology, Palaeontology, EPD, European Pollen Database, Data accuracy, Data archive, Vegetation, 15. Life on land, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, Data science, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDE.ES]Environmental Sciences/Environmental and Society, Europe, pollen analysis, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract: Pollen stratigraphies are the most spatially extensive data available for the reconstruction of past land-cover change. Detailed knowledge of past land-cover is becoming increasingly important to evaluate the present trends in, and drivers of, vegetation composition. The European Pollen Database (EPD) was established in the late 1980s and developed in the early 1990s to provide a structure for archiving, exchanging, and analysing Quaternary pollen data from Europe. It provides a forum for scientists to meet and engage in collaborative investigations or data analysis. In May 2007 several EPD support groups were developed to assist in the task of maintaining and updating the database. The mapping and data accuracy work group (MADCAP) aims to produce an atlas of past plant distributions as detected by pollen analyses in Europe, in order to meet the growing need for this data from palaeoecologists and the wider scientific community. Due to data handling problems in the past, a significant number of EPD datasets have errors. The initial task of the work group, therefore, was a systematic review of pollen sequences, in order to identify and correct errors. The EPD currently (January 2009) archives 1,032 pollen sequences, of which 668 have age-depth models that allow chronological comparison. Many errors have been identified and corrected, or flagged for users, most notably errors in the pollen count data. The application of spatial analyses to pollen data is related to the number of data points that are available for analysis. We therefore take this opportunity to encourage the submission of pollen analytical results to the EPD or other relevant pollen databases. Only in this way will the scientific community be able to gain a better understanding of past vegetation dynamics. peerReviewed
Published: 2009
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31. Pollen productivity estimates of key European plant taxa for quantitative reconstruction of past vegetation: a review

Author: Brostrom, Anna, Nielsen, Anne Brigitte, Gaillard, M.J., Hjelle, Kari, Mazier, Florence, Binney, Heather, Bunting, Jane, Fyfe, Ralph, Meltsov, Viveca, Poska, Anneli, Rasanen, Satu, Soepboer, Welmoed, von Stedingk, Henirk, Sugita, Shinya, Geobiosphere Science Centre, Lund University, Geobiosphere Science Centre, Lund University [Lund]-Lund University [Lund], Department of Quaternary Geology, Geological Survey of Denmark and Greenland (GEUS)-Geological Survey of Denmark and Greenland (GEUS), School of Pure and Applied Natural Sciences, University of Kalmar, Natural History Collections, University of Bergen (UiB)-University of Bergen (UiB), Géographie de l'environnement (GEODE), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Palaeoecology Laboratory, University of Southampton-University of Southampton, Department of Geography, University of Hull-University of Hull, School of Geography, Plymouth University-Plymouth University, Institute of Geology at Tallin University of technology, Institute of Geology at Tallin University of Technology, University of Technology-University of Technology, Department of Geography [Oulu], University of Oulu, Department of Palaeoecology, Utrecht University [Utrecht]-Utrecht University [Utrecht], Department of Forest ecology and Management, Department of Forest Ecology and Management, Swedish University of Agricultural Sciences (SLU)-Swedish University of Agricultural Sciences (SLU), University of Minnesota System, and Gil, Emilie
Subjects: Pollen productivity estimates (PPE, Herb taxa, [SHS.GEO] Humanities and Social Sciences/Geography, Tree taxa, [SHS.GEO]Humanities and Social Sciences/Geography, Landscape reconstruction algorithm (LRA), Moss polsters, Lake sediments
Abstract: International audience; Information on the spatial distribution of past vegetation on local, regional and global scales is increasingly used within climate modelling, nature conservancy and archaeology. It is possible to obtain such information from fossil pollen records in lakes and bogs using the landscape reconstruction algorithm (LRA) and its two models, REVEALS and LOVE. These models assume that reliable pollen productivity estimates (PPEs) are available for the plant taxa involved in the quantitative reconstruc -tions of past vegetation, and that PPEs are constant through time. This paper presents and discusses the PPEs for 15 tree and 18 herb taxa obtained in nine study areas of Europe. Observed differences in PPEs between regions may be explained by methodological issues and environmental variables, of which climate and related factors such as reproduction strategies and growth forms appear to be the most important. An evaluation of the PPEs at hand so far suggests that they can be used in modelling applications and quantitative reconstructions of pastvegetation, provided that consideration of past environmental variability within the region is used to inform selection of PPEs, and bearing in mind that PPEs might have changed through time as a response to climate change. Application of a range of possible PPEs will allow a better evaluation of the results.
Published: 2008

32. Big Data Palaeoecology reveals significant variation in Black Death mortality in Europe [Preprint]

Author: Izdebski, A., Guzowski, P., Poniat, R., Masci, L., Palli, J., Vignola, C., Bauch, M., Cocozza, C., Fernandes, R., Ljungqvist, F. C., Newfield, T., Seim, A., Abel-Schaad, D., Alba-Sánchez, F., Björkman, L., Brauer, A., Brown, A., Czerwiński, S., Ejarque, A., Fiłoc, M., Florenzano, A., Fredh, E. D., Fyfe, R., Jasiunas, N., Kołaczek, P., Kouli, K., 1, Kozáková, R., Kupryjanowicz, M., Lagerås, P., Lamentowicz, M., Lindbladh, M., López-Sáez, J. A., Luelmo-Lautenschlaeger, R., Marcisz, K., Mazier, F., Mensing, S., Mercuri, A. M., Milecka, K., Miras, Y., Noryśkiewicz, A. M., Novenko, E., Obremska, M., Panajiotidis, S., Papadopoulou, M. L., Pędziszewska, A., Pérez-Díaz, S., Piovesan, G., Pluskowski, A., Pokorny, P., Poska, A., Reitalu, T., Rösch, M., Sadori, L., Sá Ferreira, C., Sebag, D., Słowiński, M., Stančikaitė, M., Stivrins, N., Tunno, I., Veski, S., Wacnik, A., Masi, A., Universidad de Cantabria, Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University of Bialystok, Department of Earth Sciences, Sapienza University of Rome, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Department of Environmental Biology, Sapienza University of Rome, Università degli studi della Tuscia [Viterbo], Leibniz Institute for the History and Culture of Eastern Europe (GWZO), Universität Leipzig, ArchaeoBioCenter, Ludwig-Maximilians-Universität München, München, Germany, School of Archaeology, University of Oxford, Oxford, UK, Masaryk University [Brno] (MUNI), Stockholm University, Bolin Centre for Climate Research, Swedish Collegium for Advanced Study [Uppsala], Department of History, Georgetown University, Washington DC, USA, Department of biology, georgetown University, Washington DC, Chair of Forest Growth and Dendroecology, University of Freiburg, Institute of Botany [Innsbruck], Leopold Franzens Universität Innsbruck - University of Innsbruck, Universidad de Granada = University of Granada (UGR), Viscum Pollenanalys & Miljöhistoria, Nässjö, Sweden, German Research Centre for Geosciences - Helmholtz-Centre Potsdam (GFZ), Institute of Geosciences [Potsdam], University of Potsdam = Universität Potsdam, Wessex Archaeology [Salisbury], Department of Archaeology and Centre for Past Climate Change, University of Reading, Reading, UK, Adam Mickiewicz University in Poznań (UAM), Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Department of Palaeobiology, Faculty of Biology, University of Białystok, Białystok, Poland, Laboratory of Palynology and Palaeobotany, Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy, The Arctic University of Norway [Tromsø, Norway] (UiT), School of Geography, Earth and Environmental Sciences [Plymouth] (SoGEES), Plymouth University, University of Latvia (LU), National and Kapodistrian University of Athens (NKUA), Institute of Archaeology of the Czech Academy of Sciences, Prague, The Archaeologists, National Historical Museums, Lund, Sweden, Southern Swedish Forest Research Centre, Swedish University of Agricultural Sciences (SLU), Environmental Archaeology Research Group, Institute of History, CSIC, Madrid, Spain, Department of Geography, Universidad Autónoma de Madrid, Madrid, Spain, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Geography, University of Nevada, Reno, USA, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Nicolaus Copernicus University [Toruń], MSU Faculty of Geography [Moscow], Lomonosov Moscow State University (MSU), Institute of Geography, Russian Academy of Sciences, Moscow, Russian Federation, Institute of Geological Sciences, Polish Academy of Sciences, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Laboratory of Forest Botany-Geobotany, School of Forestry and Natural Environment, Aristotle University of Thessaloniki, Thessaloniki, Greece, University of Cologne, Faculty of Biology [Gdansk, Poland], University of Gdańsk (UG), Department of Geography, Urban and Regional Planning, Universidad de Cantabria, Santander, Spain., Centre for Theoretical Studies, Charles University, Czechia (CTS), Charles University [Prague] (CU)-Czech Academy of Sciences [Prague] (CAS), Institute of Geology at Tallinn, Tallinn University of Technology (TTÜ), Universität Heidelberg [Heidelberg] = Heidelberg University, Queen's University [Belfast] (QUB), IFP Energies nouvelles (IFPEN), Institute of Geography and Spatial Organization, Polish Academy of Sciences, Nature Research Centre, Institute of Geology and Geography, Vilnius, Lithuania, Center for Accelerator Mass Spectrometry (CAMS), Lawrence Livermore National Laboratory, Lawrence, CA, USA, W. Szafer Institute of Botany, Polish Academy of Sciences, European Project: 263735,EC:FP7:ERC,ERC-2010-StG_20091209,TEC(2010), Max Planck Institute for the Science of Human History, Kahlaische Str. 10, 07745, Jena, Germany, Faculty of History and International Relations, University of Bialystok, Bialystok, Poland, Department of Earth Science, Sapienza University of Rome, Rome, Italy, Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy, Leibniz Institute for the History and Culture of Eastern Europe (GWZO), Leipzig, Germany, Swedish Collegium for Advanced Study, Uppsala, Sweden, Chair of Forest Growth and Dendroecology, Institute of Forest Sciences, Albert-Ludwigs-University Freiburg, Freiburg, Universität Innsbruck [Innsbruck], GFZ-German Research Centre for Geosciences, Section Climate Dynamics and Landscape Evolution, Potsdam, Germany, Institute of Geosciences, University of Potsdam, Potsdam, Germany, Wessex Archaeology, Portway House, Salisbury, UK, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), The Arctic University of Norway (UiT), Institute of Archeology, Academy of Sciences of the Czech Republic, Prague, Czech Republi, Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Faculty of Geography, Lomonosov Moscow State University, Moscow, Russia., Department of Quaternary Research, Institute of Geography Russian Academy of Science, Moscow, Russia, Institute of Geological Sciences, Polish Academy of Sciences, Warsaw, Poland., Laboratory of Palaeoecology and Archaeobotany, Department of Plant Ecology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland., Charles University [Prague] (CU), Department of Geology, Tallinn University of Technology, Tallinn, Estonia, Lund University [Lund], Department of Geology, Tallinn University of Technology, Tallinn, Estonia., Institute of Ecology and Earth Sciences, University of Tartu, Tartu, Estonia, University of Tartu, Universität Heidelberg [Heidelberg], IFP Energies Nouvelles, Earth Sciences and Environmental Technologies Division, Rueil-Malmaison, Rueil-Malmaison, Past Landscape Dynamics Laboratory, Institute of Geography and Spatial Organization, Polish Academy of Sciences, Warsaw, Poland., 3 Department of Geology, Tallinn University of Technology, Tallinn, Estonia, W. Szafer Institute of Botany, Polish Academy of Sciences, Kraków, Poland., Institute of History, Jagiellonian University in Krakow, Krakow, Poland, Department of Agriculture and Forest Sciences (Dafne), University of Tuscia, Viterbo, Italy, Department of Ecological and Biological Sciences (Deb), University of Tuscia, Viterbo, Italy., Faculty of Arts, Masaryk University, Brno, Czech Republic, Department of Botany, University of Innsbruck, Innsbruck, Austria, Department of Botany, University of Granada, Granada, Spain, Climate Change Ecology Research Unit, Adam Mickiewicz University, Poznań, Poland., Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne (UCA)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), ISEM, UMR 5554, Université Montpellier, CNRS, EPHE, IRD, Montpellier, Museum of Archaeology, University of Stavanger, Stavanger, Norway, School of Geography, Earth and Environmental Science, University of Plymouth, Plymouth, UK, Department of Geography, University of Latvia, Riga, Latvia., Climate Change Ecology Research Unit, Adam Mickiewicz University, Poznań, Poland, Department of Geology and Geoenvironment, National and Kapodistrian University of Athens, Athens, Greece, Southern Swedish Forest Research Centre, Swedish University of Agricultural Sciences, Alnarp, Sweden, Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Anthropocene Research Unit, Faculty of Geographical and Geological Sciences, Adam Mickiewicz University, Poznań, CNRS, HNHP UMR 7194, Muséum National d’Histoire Naturelle, Institut de Paléontologie Humaine, Paris, France, Institute of Archaeology, Faculty of History, Nicolaus Copernicus University, Toruń, Poland., Centre for Climate Change Research, Nicolaus Copernicus University, Toruń, Poland, Institute of Geography, University of Cologne, Cologne, Germany, Department of Ecological and Biological Sciences (Deb), University of Tuscia, Viterbo, Italy, Centre for Theoretical Study, Charles University and Academy of Sciences of the Czech Republic, Prague, Czech Republic., Department of Physical Geography and Ecosystem Science, Lund University, Lund, Sweden, Department of Pre- and Early History and West Asian Archaeology, University of Heidelberg, Heidelberg, Germany, School of Natural and Built Environment, Queen’s University, Belfast, Northern Ireland, Department of Geography, University of Latvia, Riga, Latvia, Institute of Latvian History, University of Latvia, Riga, Latvia., Max Planck Society, Estonian Research Council, European Research Council, Latvian Council of Science, Ministerio de Economía y Competitividad (España), Ministerio de Educación, Cultura y Deporte (España), Swedish Research Council, Volkswagen Foundation, Ministerio de Ciencia e Innovación (España), López Sáez, José Antonio [0000-0002-3122-2744], López Sáez, José Antonio, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD)
Subjects: Land-use changes, Ecology, black death pandemic, Humaniora: 000::Arkeologi: 090 [VDP], palaeoecological data, [SHS.GEO]Humanities and Social Sciences/Geography, paleoecology, palynology, big data, paleoecology, Europe, big data, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, [SDE]Environmental Sciences, [SHS.HIST]Humanities and Social Sciences/History, palynology, Ecology, Evolution, Behavior and Systematics
Abstract: The authors acknowledge the following funding sources: Max Planck Independent Research Group, Palaeo-Science and History Group (A.I., A.M. and C.V.); Estonian Research Council #PRG323, PUT1173 (A.Pos., T.R., N.S. and S.V.); European Research Council #FP7 263735 (A.Bro. and A.Plu.), #MSC 655659 (A.E.); Georgetown Environmental Initiative (T.N.); Latvian Council of Science #LZP-2020/2-0060 (N.S. and N.J.); LLNL-JRNL-820941 (I.T.); NSF award #GSS-1228126 (S.M.); Polish-Swiss Research Programme #013/2010 CLIMPEAT (M.Lam.), #086/2010 CLIMPOL (A.W.); Polish Ministry of Science and Higher Education #N N306 275635 (M.K.); Polish National Science Centre #2019/03/X/ST10/00849 (M.Lam.), #2015/17/B/ST10/01656 (M.Lam.), #2015/17/B/ST10/03430 (M.So.), #2018/31/B/ST10/02498 (M.So.), #N N304 319636 (A.W.); SCIEX #12.286 (K.Mar.); Spanish Ministry of Economy and Competitiveness #REDISCO-HAR2017-88035-P (J.A.L.S.); Spanish Ministry of Education, Culture and Sports #FPU16/00676 (R.L.L.); Swedish Research Council #421-2010-1570 (P.L.), #2018-01272 (F.C.L. and A.S.); Volkswagen Foundation Freigeist Fellowship Dantean Anomaly (M.B.), Spanish Ministry of Science and Innovation #RTI2018-101714-B-I00 (F.A.S. and D.A.S.), OP RDE, MEYS project #CZ.02.1.01/0.0/0.0/16_019/0000728 (P.P.)., The Black Death (1347–1352 ce) is the most renowned pandemic in human history, believed by many to have killed half of Europe’s population. However, despite advances in ancient DNA research that conclusively identified the pandemic’s causative agent (bacterium Yersinia pestis), our knowledge of the Black Death remains limited, based primarily on qualitative remarks in medieval written sources available for some areas of Western Europe. Here, we remedy this situation by applying a pioneering new approach, ‘big data palaeoecology’, which, starting from palynological data, evaluates the scale of the Black Death’s mortality on a regional scale across Europe. We collected pollen data on landscape change from 261 radiocarbon-dated coring sites (lakes and wetlands) located across 19 modern-day European countries. We used two independent methods of analysis to evaluate whether the changes we see in the landscape at the time of the Black Death agree with the hypothesis that a large portion of the population, upwards of half, died within a few years in the 21 historical regions we studied. While we can confirm that the Black Death had a devastating impact in some regions, we found that it had negligible or no impact in others. These inter-regional differences in the Black Death’s mortality across Europe demonstrate the significance of cultural, ecological, economic, societal and climatic factors that mediated the dissemination and impact of the disease. The complex interplay of these factors, along with the historical ecology of plague, should be a focus of future research on historical pandemics., Max Planck Independent Research Group, Palaeo-Science and History Group, Estonian Research Council PRG323 PUT1173, European Research Council (ERC) European Commission FP7 263735 MSC 655659, Georgetown Environmental Initiative, Latvian Ministry of Education and Science LZP-2020/2-0060 LLNL-JRNL-820941, National Science Foundation (NSF) GSS-1228126, Polish-Swiss Research Programme 013/2010 086/2010, Ministry of Science and Higher Education, Poland N306 275635, Polish National Science Centre 2019/03/X/ST10/00849 2015/17/B/ST10/01656 2015/17/B/ST10/03430 2018/31/B/ST10/02498 N N304 319636, SCIEX 12.286, Spanish Government REDISCO-HAR2017-88035-P FPU16/00676, Swedish Research Council, European Commission 421-2010-1570 2018-01272, Volkswagen Foundation Freigeist Fellowship Dantean Anomaly, Spanish Government RTI2018-101714-B-I00, OP RDE, MEYS project CZ.02.1.01/0.0/0.0/16_019/0000728
Published: 2022
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33. Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice

Author: Lettie E. Rawlins, Hashem Almousa, Shazia Khan, Stephan C. Collins, Miroslav P. Milev, Joseph Leslie, Djenann Saint-Dic, Valeed Khan, Ana Maria Hincapie, Jacob O. Day, Lucy McGavin, Christine Rowley, Gaurav V. Harlalka, Valerie E. Vancollie, Wasim Ahmad, Christopher J. Lelliott, Asma Gul, Binnaz Yalcin, Andrew H. Crosby, Michael Sacher, Emma L. Baple, Rawlins, Lettie E [0000-0002-6764-253X], Almousa, Hashem [0000-0003-2679-5350], Collins, Stephan C [0000-0002-1533-3380], Leslie, Joseph [0000-0003-0972-8818], Saint-Dic, Djenann [0000-0001-9328-7108], Khan, Valeed [0000-0002-3840-5439], Day, Jacob O [0000-0002-6020-510X], Harlalka, Gaurav V [0000-0001-8968-2447], Vancollie, Valerie E [0000-0003-1547-1975], Lelliott, Christopher J [0000-0001-8087-4530], Yalcin, Binnaz [0000-0002-1924-6807], Crosby, Andrew H [0000-0003-3667-9054], Sacher, Michael [0000-0003-2926-5064], Baple, Emma L [0000-0002-6637-3411], Apollo - University of Cambridge Repository, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital [Exeter, UK] (RDEH), Concordia University [Montreal], International Islamic University [Islamabad, Pakistan] (2IU), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Rehman Medical Institute [Peshawar, Pakistan] (RMI), Plymouth University, University Hospitals Plymouth NHS Trust [Plymouth, UK] (UHP), The Wellcome Trust Sanger Institute [Cambridge], Rajarshi Shahu College of Pharmacy [Malvihir, Buldana, India] (RSCP), Quaid-i-Azam University (QAU), McGill University = Université McGill [Montréal, Canada], and Dupuis, Christine
Subjects: [SDV] Life Sciences [q-bio], Cancer Research, Mice, Phenotype, Neurodevelopmental Disorders, [SDV]Life Sciences [q-bio], Genetics, Microcephaly, Animals, Humans, Molecular Biology, Genetics (clinical), Ecology, Evolution, Behavior and Systematics
Abstract: The highly evolutionarily conserved transport protein particle (TRAPP) complexes (TRAPP II and III) perform fundamental roles in subcellular trafficking pathways. Here we identified biallelic variants in TRAPPC10, a component of the TRAPP II complex, in individuals with a severe microcephalic neurodevelopmental disorder. Molecular studies revealed a weakened interaction between mutant TRAPPC10 and its putative adaptor protein TRAPPC2L. Studies of patient lymphoblastoid cells revealed an absence of TRAPPC10 alongside a concomitant absence of TRAPPC9, another key TRAPP II complex component associated with a clinically overlapping neurodevelopmental disorder. The TRAPPC9/10 reduction phenotype was recapitulated in TRAPPC10-/- knockout cells, which also displayed a membrane trafficking defect. Notably, both the reduction in TRAPPC9 levels and the trafficking defect in these cells could be rescued by wild type but not mutant TRAPPC10 gene constructs. Moreover, studies of Trappc10-/- knockout mice revealed neuroanatomical brain defects and microcephaly, paralleling findings seen in the human condition as well as in a Trappc9-/- mouse model. Together these studies confirm autosomal recessive TRAPPC10 variants as a cause of human disease and define TRAPP-mediated pathomolecular outcomes of importance to TRAPPC9 and TRAPPC10 mediated neurodevelopmental disorders in humans and mice.
Published: 2022
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34. In vitro effects of glyphosate-based herbicides and related adjuvants on primary culture of hemocytes from Haliotis tuberculata

Author: Jean-Marc Lebel, Katherine Costil, Adèle James, Lorna J. Dallas, Antoine Mottier, Antoine Serpentini, Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), School of Biological Sciences [Plymouth], Plymouth University, Institut Français de Recherche pour l'Exploitation de la Mer - Brest (IFREMER Centre de Bretagne), and Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)
Subjects: 0301 basic medicine, Glyphosate, Hemocytes, food.ingredient, Cell Survival, medicine.medical_treatment, Gastropoda, Viability assay, Glycine, Aquaculture, Aquatic Science, Biology, Microbiology, Lethal Dose 50, 03 medical and health sciences, chemistry.chemical_compound, food, Phagocytosis, Lysosome, medicine, Animals, Environmental Chemistry, Haliotis, Cells, Cultured, EC50, Herbicides, Neutral red retention assay, Cell Membrane, 04 agricultural and veterinary sciences, General Medicine, In vitro, Organelle membrane, 030104 developmental biology, medicine.anatomical_structure, chemistry, POEAs, 040102 fisheries, [SDV.IMM]Life Sciences [q-bio]/Immunology, 0401 agriculture, forestry, and fisheries, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, Adjuvant, Haliotis tuberculata
Abstract: International audience; Glyphosate-based herbicides are among the most produced and widely-used herbicides. Studies have shown that commercial formulations and adjuvants may be more toxic to non-target organisms than the active ingredients alone, but the mechanisms of action of these chemicals remain unclear. The aim of this study was to investigate the in vitro effects of glyphosate, a commercial formulation and adjuvant alone using primary culture of hemocytes from the European abalone Haliotis tuberculata, a commonly farmed shellfish. Glyphosate was found to have negligible effects on viability, phagocytic activities and lysosome stability even with very high doses (i.e. 100 mg L−1). By contrast, greater effects on viability were observed for the commercial formulation and adjuvant alone, with EC50 values of 41.42 mg L−1 and 1.85 mg L−1, respectively. These results demonstrate that the toxic sublethal effects (i.e. phagocytic activity and destabilization of lysosomal membranes) of formulated glyphosate came from adjuvants and suggest they may be related to cell and organelle membrane destabilization.
Published: 2020
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35. Platooning Control for Heterogeneous Sailboats Based on Constant Time Headway

Author: Christophe Viel, Ulysse Vautier, Jian Wan, Luc Jaulin, Plymouth University, Lab-STICC_ENSTAB_CID_PRASYS, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)
Subjects: Platooning, 050210 logistics & transportation, Computer science, Mechanical Engineering, 05 social sciences, Control (management), Heterogeneous fleet, Wind direction, Nonlinear control, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Computer Science Applications, Vehicle dynamics, Acceleration, Control theory, 0502 economics and business, Automotive Engineering, Path (graph theory), Non-linear control, Trajectory, Autonomous sailboats, Constant (mathematics)
Abstract: International audience; This paper addresses the problem of platooning control for a fleet of heterogeneous sailboats. The platooning maintains a constant time headway (CTH) between sailboats following a circular path, a complex problem for sailboats due to the influence of wind direction. First, the desired acceleration based on the CTH and the sailboat velocity needed to converge to the platooning is defined. Second, a control of sailboat orientation to manage the sailboat acceleration is proposed. The proposed platooning strategy adapts to the specific characteristics of sailboats, which are different from other motorized marine vehicles. Two tack strategies can be used for the method: the first is to regulate the sailboat velocity; the second is to go front of the wind while staying in a short corridor. The desired acceleration for fulfilling the platooning has been derived and validated. The simulation results demonstrate the effectiveness of the proposed approach in comparison with an optimal receding horizon control algorithm.
Published: 2020
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36. Construction Field Monitoring of a COB Prototype Building

Author: Azil, A., Le Guern, M., Karim Touati, Gomina, M., Nassim Sebaibi, Boutouil, M., Streiff, F., Goodhew, S., Louahlia, H., Laboratoire de recherche de l'ESITC, École Supérieure d'ingénieurs des Travaux de la Construction (ESITC Caen), Laboratoire de cristallographie et sciences des matériaux (CRISMAT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Parc Naturel Régional des Marais du Cotentin et du Bessin, Plymouth University, Laboratoire Universitaire des Sciences Appliquées de Cherbourg (LUSAC), Normandie Université (NU)-Normandie Université (NU), Sofiane Amziane, Mohammed Sonebi, and COMUE Normandie Université - Laboratoire de Recherche ESITC Caen, France
Subjects: [SPI]Engineering Sciences [physics], Monitoring, Density, Cob, Prototype building, Compressive strength
Abstract: Cob is an earthen building material made by soil, fibres and water used for millennia. However, cob construction disappeared out during the nineteenth century. These last years, it is experiencing a renaissance in Northwestern France and Southern England. Due to a limited technical knowledge, the investigation of engineering properties is important for modern design practice and code requirements. Moreover, to ensure building properties, it is necessary to have same quality mix along the building phases. The aim of this study is to determine material variation during the monitoring of a cob prototype building in Normandy (France). This study investigated structural cob mix composition, water content, density, mechanical properties and thermal conductivity. Specimens shape used were cylindrical 110 x H220 mm and prismatic 300 x 300 x 70 mm. Results indicated a variation in cob mix (water content, materials proportions) between three different lifts. These variations lead to different densities and, consequently, to variables compressive strengths: 0.99 to 1.38 MPa and thermal conductivities from 0.610 - 0.816 W.m-1∙K-1.
Published: 2022
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37. Human–nature connectedness as a pathway to sustainability: A global meta‐analysis

Author: Barragan‐jason, Gladys, de Mazancourt, Claire, Parmesan, Camille, Singer, Michael, Loreau, Michel, Station d'Ecologie Théorique et Expérimentale (SETE), Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Agrobiosciences, Interactions et Biodiversité (FR AIB), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), University of Texas at Austin [Austin], Plymouth University, ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010), and European Project: 666971,H2020,ERC-2014-ADG,BIOSTASES(2015)
Subjects: meta-analysis, human–nature connectedness, environmental education, [SDE]Environmental Sciences, nature conservation, proenvironmental behavior, human health, sustainability, nature-based solutions, people and nature, human-nature connectedness
Abstract: International audience; Internationally agreed sustainability goals are being missed. Here, we conduct global meta-analyses to assess how the extent to which humans see themselves as part of nature—known as human–nature connectedness (HNC)—can be used as a leverage point to reach sustainability. A meta-analysis of 147 correlational studies shows that individuals with high HNC had more pronature behaviours and were significantly healthier than those with low HNC. A meta-analysis of 59 experimental studies shows significant increases in HNC after manipulations involving contact with nature and mindfulness practices. Surprisingly, this same meta-analysis finds no significant effect of environmental education on HNC. Thus, HNC is positively linked to mind-sets that value sustainability and behaviours that enhance it. Further, we argue that HNC can be enhanced by targeted practices, and we identify those most likely to succeed. Our results suggest that enhancing HNC, via promotion of targeted practices, can improve sustainability and should be integrated into conservation policy.
Published: 2022
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38. OC6 Phase Ib : validation of the CFD predictions of difference-frequency wave excitation on a FOWT semisubmersible

Author: Rupesh Kumar, SA Brown, Hamid Sarlak, Amy Robertson, Haoran Li, Stefan Netzband, Martyn Hann, Beatriz Méndez López, Romain Pinguet, Wei Shi, Xinmeng Zeng, Lu Wang, Yi Hsiang Yu, Edward Ransley, Malwin Wermbter, Jason Jonkman, Yang Zhou, Qing Xiao, Adrià Borràs Nadal, Erin Elizabeth Bachynski-Polic, Arjen Koop, National Renewable Energy Laboratory (NREL), Maritime Research Institute Netherlands (MARIN), IFP Energies nouvelles (IFPEN), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Institut de Recherche sur les Phénomènes Hors Equilibre (IRPHE), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Principle Power, Inc. (PPI), Emeryville, CA, USA, Dalian University of Technology, University of Strathclyde [Glasgow], University of Ulsan, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Plymouth University, Hamburg University of Technology (TUHH), Centro Nacional de Energías Renovables - Fundación CENER-CIEMAT (CENER), and Technical University of Denmark [Lyngby] (DTU)
Subjects: Environmental Engineering, 020209 energy, Phase (waves), Ocean Engineering, 02 engineering and technology, Computational fluid dynamics, 7. Clean energy, 01 natural sciences, Resonance (particle physics), 010305 fluids & plasmas, [SPI]Engineering Sciences [physics], Nonlinear excitation, Validation, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Surge, Offshore wind, OC6, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Physics, business.industry, Mechanics, Nonlinear system, Offshore wind power, Structural load, Bichromatic wave, CFD, business, TC, Excitation
Abstract: International audience; During the previous OC511 project, state-of-the-art mid-fidelity engineering tools for floating wind systems were found to consistently underpredict the nonlinear, low-frequency responses of semisubmersible offshore wind platforms, leading to substantial errors in the structural loads because of low-frequency surge and pitch resonance. To examine this underprediction, a coordinated investigation with computational fluid dynamics (CFD) simulations and model-basin experiments was carried out. Both investigations involved a fixed and simplified OC5-DeepCwind semisubmersible in bichromatic waves. The wave excitations—especially the nonlinear, difference-frequency excitation—on the structure from the CFD simulations were compared to the experimental measurements for validation, with uncertainty analyses for both the experimental and the CFD results. Further, the wave excitations on each column of the semisubmersible were measured separately in the experiment, allowing the validation of the CFD results to be done on a per-column basis. Overall, the CFD predictions of the difference-frequency excitations agree with the experimental measurements, suggesting the CFD solutions can be used as a reference for tuning and improving the engineering-level tools and can provide a means to better understand the underprediction at low frequencies.
Published: 2021
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39. Olive groves around the lake. A ten-thousand-year history of a Cretan landscape (Greece) reveals the dominant role of humans in making this Mediterranean ecosystem

Author: Roberto Sulpizio, Isabelle Jouffroy-Bapicot, Maxime Debret, Sophie Field, Kevin Walsh, Neil Roberts, Boris Vannière, Pierre Sabatier, Giovanni Zanchetta, Tiziana Pedrotta, Willy Tinner, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux (UAR 3124) (MSHE), Oeschger Centre for Climate Change Research (OCCR), University of Bern, Morphodynamique Continentale et Côtière (M2C), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), School of Geography, Earth and Environmental Sciences [Plymouth] (SoGEES), Plymouth University, University of Bari Aldo Moro (UNIBA), University of Pisa - Università di Pisa, Environnements, Dynamiques et Territoires de la Montagne (EDYTEM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut d'Etudes Avancées [AMU] (IMéRA), Aix Marseille Université (AMU), Universität Bern [Bern], Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire Chrono-environnement (UMR 6249) (LCE), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Universität Bern [Bern] (UNIBE), Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux (MSHE), Dipartimento di Scienze Delle Terra, University of Pisa, School of Archaeology, University of Oxford, and BioArCh, Department of Archaeology, University of York, York, YO10 5NG, UK
Subjects: 010506 paleontology, Archeology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Biodiversity, Climate change, Woodland, Land cover, Socio-ecosystem, Mediterranean, 010502 geochemistry & geophysics, 01 natural sciences, Anthropisation, Crete, Holocene, Human impacts, Land-use, Olive grove, Paleoecology, 11. Sustainability, 14. Life underwater, ComputingMilieux_MISCELLANEOUS, Ecology, Evolution, Behavior and Systematics, 0105 earth and related environmental sciences, Global and Planetary Change, Land use, Flood myth, Ecology, Geology, Vegetation, 15. Life on land, Geography, 13. Climate action, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, [SDE]Environmental Sciences
Abstract: (IF 4.45: Q1); International audience; The reconstruction of millennial-scale interactions between ecosystems and societies can provide unique and valuable references for understanding the creation of cultural landscapes and help elucidate their value, weaknesses and legacies. Among the most emblematic forms of Mediterranean land use, olive groves and pastoralism have occupied a prominent place. Therefore, it is vital to know when, how, and with what ecological consequences these practices were established and developed. Located in the southern part of the Aegean Sea, Crete is the largest island of Greece. The island is characterised by a long human history of land use, but our understanding of past environmental changes for the entire Holocene is fragmentary. This paper presents a new investigation of Lake Kournas in Crete, where recent coring provided a 15-m sequence covering ten millennia of land cover and land-use history. The study of this new core involves the analysis of the sediment dynamics, flood deposits, pollen, diatoms, fungal and algal remains, and microcharcoals. Results show that ecosystem development near Lake Kournas was not a linear process. They reveal linkages and feedbacks between vegetation, biodiversity, fire, human impact, erosion, and climate change. A possible human occupation and agro-pastoral activities around the lake may have been detected as early as 9500 cal BP, perhaps in a transitional phase between the Mesolithic and the Neolithic. At 8500 cal BP, climatic conditions may have promoted the expansion of the evergreen oak woodland. However, human impact was probably the most important driver of ecosystem change with the establishment of an agro-system after 8000 years ago. Thereafter, the trajectory of Kournas’ lake and catchment ecosystems from the Mid to Late Holocene follow the rhythm of land-use change. Among the traditional Mediterranean land uses, olive cultivation locally played a major role in the socio-ecosystem interactions, providing economic benefits but also destabilising soils. During the last six millennia, three main phases of olive cultivation occurred during the Final Neolithic-Minoan period, the Hellenistic-Roman-Byzantine (HRB) period and Modern times. Along with the changing land use under the successive political and economic influences rules, the resilience capacities of vegetation permitted it to shift back to higher biodiversity again after decreasing phases. Forest vegetation was always able to recover until the onset of the Venetian period (13th century), when woodlands were dramatically reduced. Only during the past century has forest vegetation slightly recovered, while the flood regime had already been altered during previous centuries. During the past 100 years, biodiversity markedly declined, probably in response to the industrialization of agriculture.
Published: 2021
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40. Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma

Author: Nishanthan Rajakumaraswamy, Simon Rule, Krimo Bouabdallah, John Radford, Loic Ysebaert, Christopher Fegan, Stephen E. Spurgeon, Gilles Salles, Alexey V. Danilov, Rita Humeniuk, Xi Huang, Pankaj Bhargava, Guillaume Cartron, Biao Li, Martin J. S. Dyer, Harriet S. Walter, Andrew Davies, Daniel J. Hodson, Franck Morschhauser, Juliane M. Jürgensmeier, Morschhauser, Franck [0000-0002-3714-9824], Walter, Harriet S [0000-0003-2618-711X], Hodson, Daniel James [0000-0001-6225-2033], Rule, Simon A [0000-0001-8937-6351], Rajakumaraswamy, Nishanthan [0000-0002-0226-0637], Salles, Gilles [0000-0002-9541-8666], Apollo - University of Cambridge Repository, Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Ernest and Helen Scott Haematological Research Institute, University of Leicester, City of Hope National Medical Center, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Cambridge [UK] (CAM), University Hospital of Wales (UHW), Plymouth University, University of Manchester [Manchester], The Christie NHS Foundation Trust [Manchester, Royaume-Uni], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHU Bordeaux [Bordeaux], University of Southampton, Knight Cancer Institute, Oregon Health and Science University [Portland] (OHSU), Gilead Sciences, Inc. [Foster City, CA, USA], Hospices Civils de Lyon (HCL), Université de Lyon, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Herrada, Anthony, CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospital of Wales [Cardiff, UK], Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Walter, Harriet S. [0000-0003-2618-711X], and Rule, Simon A. [0000-0001-8937-6351]
Subjects: [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Adult, Male, Cancer Research, Letter, Entospletinib, Indazoles, Lymphoma, B-Cell, Cancer therapy, Drug development, [SDV.CAN]Life Sciences [q-bio]/Cancer, Antineoplastic Agents, 03 medical and health sciences, 0302 clinical medicine, 692/699/67/1059, [SDV.CAN] Life Sciences [q-bio]/Cancer, immune system diseases, Phase (matter), hemic and lymphatic diseases, medicine, Humans, 692/308/153, B-cell lymphoma, Purine metabolism, Protein Kinase Inhibitors, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Aged, Quinazolinones, 0303 health sciences, Manchester Cancer Research Centre, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Imidazoles, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology, Middle Aged, medicine.disease, 3. Good health, Pyrimidines, Oncology, Purines, 030220 oncology & carcinogenesis, Pyrazines, Cancer research, Female, Idelalisib, Previously treated, business
Abstract: B-cell receptor (BCR) signaling pathway inhibitors (including Bruton’s tyrosine kinase [BTK] inhibitors, and phosphatidylinositol-3 kinase inhibitors [PI3Ki]) have shown clinical efficacy in non-Hodgkin lymphoma (NHL). However, responses to these agents have been limited in depth and duration. This may be due to resistance to PI3Kδ and BTK inhibitors as monotherapy [1,2,3,4,5]. The emergence of resistant clones may be addressed by combining these 2 classes of drugs. Furthermore, tolerability of these drug classes has been a concern. Combination therapy using lower doses of one or more classes of inhibitors may address some limitations.
Published: 2021
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41. Restricted Orientation Dubins Path With Application to Sailboats

Author: Ulysse Vautier, Christophe Viel, Robert Hone, Jian Wan, Luc Jaulin, Ming Dai, Plymouth University, Lab-STICC_ENSTAB_CID_PRASYS, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT), and Zhejiang University of Science and Technology
Subjects: 0209 industrial biotechnology, Turning, Control and Optimization, Computer science, Biomedical Engineering, 02 engineering and technology, Orientation (graph theory), Topology, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Computer Science::Robotics, 020901 industrial engineering & automation, Artificial Intelligence, Position (vector), [INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, Motion planning, Path planning, Mechanical Engineering, Indexes, Dubins path, Computer Science Applications, Human-Computer Interaction, Planning, Control and Systems Engineering, Face, Face (geometry), Shortest path problem, Robot, Computer Vision and Pattern Recognition, Robots
Abstract: International audience; This paper develops a geometrical construction of a shortest Dubins path in a discontinuous orientation restricted environment. The method proposed here builds the shortest path from one pose to the other while avoiding a no-go zone in terms of orientation, and being constrained to move forward. Finally, an application to autonomous sailboats is then provided to validate the feasibility of the planned shortest path in a position keeping scenario.
Published: 2019
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42. Preface—evaluating the response of critical zone processes to human impacts with sediment source fingerprinting

Author: William H. Blake, Olivier Evrard, Allen C. Gellis, J. Patrick Laceby, Alexander J. Koiter, Environmental Monitoring and Science Division of Alberta (EMSD), Alberta Government, United States Geological Survey (USGS), Brandon University, School of Geography, Earth and Environmental Sciences [Plymouth] (SoGEES), Plymouth University, Géochimie Des Impacts (GEDI), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Hydrology, sediment tracing, Stratigraphy, 0207 environmental engineering, Critical zone, Sediment, fine-grained sediment, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, sediment fingerprinting, Anthropocene, CZ processes, Environmental science, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, 020701 environmental engineering, 0105 earth and related environmental sciences, Earth-Surface Processes
Abstract: International audience; Note: Several figures follow the manuscript text towards the end of the word file
Published: 2019
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43. Platooning Control for Sailboats Using a Tack Strategy

Author: Christophe Viel, Luc Jaulin, Jian Wan, Ulysse Vautier, Plymouth University, Zhejiang University of Science and Technology, Lab-STICC_ENSTAB_CID_PRASYS, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT), and École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)
Subjects: Platooning, 0209 industrial biotechnology, Quadrilateral, business.industry, Computer science, Control (management), Robotics, 02 engineering and technology, Mechatronics, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Computer Science Applications, Task (project management), Acceleration, 020901 industrial engineering & automation, Autonomous sailboat, Control and Systems Engineering, Control theory, [INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, Path (graph theory), Non-linear control, [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], 14. Life underwater, Artificial intelligence, Underwater, business
Abstract: International audience; This paper addresses the problem of platooning control for a fleet of sailboats. A quadrilateral path is proposed to avoid going into the wind. A tack strategy is defined to go front the wind, stay in a short corridor and regulate the sailboat acceleration, which is a challenging task in comparison to autonomous underwater vehicles (AUVs) or surface vehicles that can use motors for such regulation. Desired acceleration which guarantees to reach the platooning has been derived and validated. A method of regulating the sail angle using a proportional command is proposed to control the sailboat acceleration. Simulation results demonstrate the effectiveness of the proposed approach.
Published: 2019
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44. Holocene land cover and population dynamics in Southern France

Author: Ralph Fyfe, Jessie Woodbridge, Laure Nuninger, Florence Mazier, Elise Doyen, Alessiano Palmisano, Carole Bégeot, Jean‑françois Berger, C. Neil Roberts, Valérie Andrieu-Ponel, Julien Azuara, Sebastien Guillon, Andrew Bevan, Stephen Shennan, Environnement, Ville, Société (EVS), École normale supérieure de Lyon (ENS de Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Institute of archaeology (UCL), University College of London [London] (UCL), School of Geography, Earth and Environmental Sciences [Plymouth] (SoGEES), Plymouth University, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux (UAR 3124) (MSHE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Chrono-environnement (UMR 6249) (LCE), Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Laboratoire de chrono-écologie - CNRS (UMR6565) (LCE), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Changing the face of the Mediterranean Land cover and population since the advent of farming - Leverhulme Trust funded project (2015-2018), University of Plymouth, University College London, Environnement Ville Société (EVS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Lyon (ENSAL)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Nationale des Travaux Publics de l'État (ENTPE)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux (MSHE), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de chrono-écologie (LCE), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD), École normale supérieure - Lyon (ENS Lyon)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-École Nationale des Travaux Publics de l'État (ENTPE)-École nationale supérieure d'architecture de Lyon (ENSAL)-Centre National de la Recherche Scientifique (CNRS), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université de Perpignan Via Domitia (UPVD)
Subjects: 010506 paleontology, Archeology, human impact, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, 010504 meteorology & atmospheric sciences, aoristic weights, Population, Land cover, [SHS.DEMO]Humanities and Social Sciences/Demography, medicine.disease_cause, 01 natural sciences, Vegetation cover, law.invention, land cover, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], site count, law, population proxy, Pollen, population dynamics, medicine, Radiocarbon dating, education, radiocarbon summed probability distribution, Holocene, 0105 earth and related environmental sciences, Earth-Surface Processes, Global and Planetary Change, education.field_of_study, [SHS.STAT]Humanities and Social Sciences/Methods and statistics, Ecology, Paleontology, 15. Life on land, pollen, Southern France, Geography, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, Physical geography, Count data
Abstract: This paper describes long-term changes in human population and vegetation cover in southern France, using summed radiocarbon probability distributions and site count data as population proxies and information from fossil pollen cores as a proxy for past land cover. Southern France is particularly well-suited to this type of study as a result of previous programmes of intensive survey work and excavation in advance of large-scale construction. These make it possible to calibrate the larger scale occupation patterns in the light of the visibility issues created by the burial of archaeological sites beneath alluvial sediments. For purposes of analysis, the region was divided into three biogeographical zones (BGZ), going from the Mediterranean coast to the middle Rhône valley (MRV). All the different population proxies in a given zone show broadly similar patterns of fluctuation, though with varying levels of resolution. The long-term patterns in the different zones all show significant differences from the overall regional pattern, but this is especially the case for the non-Mediterranean middle Rhône area. Cluster analysis of pollen samples has been carried out to identify the main regional land cover types through the Holocene, which are increasingly dominated by open types over time. A variety of other pollen indicators show evidence of increasing human impact through time. Measures of human impact correlate strongly with the population proxies. A series of thresholds are identified in the population–human impact trajectory that are related to other changes in the cultural sequence. The lack of independent climate data for the region means that its impact cannot currently be assessed with confidence. However, for the later periods, it is clear that the incorporation of southern France into larger regional systems played a major role in accounting for changes in land cover and settlement.
Published: 2019
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45. Delayed sedimentary response to abrupt climate change at the Paleocene-Eocene boundary, northern Spain

Author: John J. Armitage, Stephen T. Grimes, Hayley Manners, Tom Dunkley Jones, Robert A. Duller, Univ Liverpool, Dept Earth Ocean & Ecol Sci, Liverpool L69 3BX, Merseyside, England, Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Univ Plymouth, Sch Geog Earth & Environm Sci, Plymouth PL4 8AA, Devon, England, School of Geography, Earth and Environmental Sciences [Plymouth] (SoGEES), Plymouth University, School of Geography, Earth and Environmental Sciences [Birmingham], University of Birmingham [Birmingham], and French Agence National de la Recherche, Accueil de Chercheurs de Haut Niveau call, grant 'InterRift' NERC Natural Environment Research CouncilNE/P013112/1
Subjects: PETM, Delta, TIME SCALES, 010504 meteorology & atmospheric sciences, Lag, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Climate change, 010502 geochemistry & geophysics, 01 natural sciences, CARBON, COMPENSATIONAL STACKING, RECORDS, 0105 earth and related environmental sciences, RELEASE, SEA, KeyWords Plus:THERMAL MAXIMUM, Global warming, Sediment, Geology, Radiative forcing, [SDU]Sciences of the Universe [physics], 13. Climate action, BIGHORN BASIN, Abrupt climate change, Sedimentary rock, Physical geography
Abstract: International audience; Sediment routing systems (SRSs) are a critical element of the global response to ongoing climate change. However SRS response to climate forcing is complex, fragmentary, and obscured when viewed over short, human time scales (10(-1)-10(2) yr). Over long time scales (>10(2)-10(3) yr), the aggregated, system-wide response of SRSs to climate forcing can be gleaned with more confidence from the sedimentary record, but the nature and time scales of this aggregated response to abrupt climate change are still poorly understood. Here, we investigate the aggregated temporal response of a SRS in northern Spain to abrupt climate warming at the Paleocene-Eocene thermal maximum (PETM). Our results show that terrestrial sites in northern Spain record a temporal lag of 16.5 +/- 7.5 k.y. between the onset of the PETM, defined by an abrupt negative excursion in the delta C-13 profile, and the onset of coarse-grained deposition. Within the same SRS at a deep marine site 500 km to the west, we observe a temporal lag of 16.5 +/- 1.5 k.y. using an age model that is independent of that used for the terrestrial sites. These results suggest that the aggregated, system-wide response of SRSs to present-day global warming-if we take the PETM as an appropriate modern-day analogue-may persist for many millennia into the future.
Published: 2019
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46. Efficacy of non-pharmacological interventions to treat malnutrition in older persons : A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project

Author: Roy L. Soiza, Avril Collinson, Mary Hickson, Lisette C. P. G. M. de Groot, Antonio Cherubini, Isabel Lozano-Montoya, Dorothee Volkert, Marjolein Visser, Alfonso José Cruz Jentoft, Andrea Correa-Pérez, Dominique Dardevet, Maike Wolters, Denis O'Mahony, Iosief Abraha, Marian A. E. de van der Schueren, Javier Jaramillo-Hidalgo, Antje Hebestreit, Servicio de Geriatría, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Italian National Research Centre on Aging (INRCA), Institute of Health and Community, Plymouth University, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Division of Human Nutrition and Health, Wageningen University and Research [Wageningen] (WUR), department of nutrition and health, HAN University of Applied sciences, department of nutrition and dietetics, VU University Amsterdam Medical Center, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Hospital Central de la Cruz Roja San José y Santa Adela, Department of Geriatric Medicine, Oslo University Hospital [Oslo], Department of Medicine for the Elderly, Grampian University Hospitals NHS Trust, Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, MalNutrition in the ELderly (MaNuEL) knowledge hub Joint Programming Initiative 'Healthy Diet for a Healthy Life' from the European Union's H2020 Research and Innovation Programme 696300SENATOR from the European Union 305930, European Project: 696300,H2020,H2020-ISIB-2015-1,CSA JPI HDHL 2.0(2016), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Wageningen University and Research Center (WUR)
Subjects: 0301 basic medicine, Aging, Activities of daily living, Protein–energy malnutrition, Psychological intervention, Review, Biochemistry, 0302 clinical medicine, Elderly, Quality of life, Activities of Daily Living, systematic, Dietary supplementation, Elderly, dietary supplementation, 2. Zero hunger, Protein energy malnutrition, Review, systematic, Aged, Body Weight, Exercise, Humans, Malnutrition, Muscle Strength, Nutritional Status, Quality of Life, Dietary Supplements, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Systematic review, Neurology, Meta-analysis, Biotechnology, Systematic, medicine.medical_specialty, 03 medical and health sciences, medicine, SDG 2 - Zero Hunger, Molecular Biology, VLAG, Global Nutrition, Wereldvoeding, business.industry, dietary supplementation, medicine.disease, 030104 developmental biology, Physical therapy, business, Body mass index, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery
Abstract: Introduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. Results: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. Conclusions: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.
Published: 2019
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47. Role of Atmospheric Indices in Describing Inshore Directional Wave Climate in the United Kingdom and Ireland

Author: Andy Saulter, Gerd Masselink, Guillaume Dodet, Adam A. Scaife, Tim Scott, Bruno Castelle, Robert Jak McCarroll, Nick Dunstone, School of Biological and Marine Sciences, Plymouth University, Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Océanographie Physique et Spatiale (LOPS), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), United Kingdom Met Office [Exeter], College of Engineering, Mathematics and Physical Sciences [Exeter] (EMPS), University of Exeter, Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), and ANR-17-CE01-0014,SONO,Marier les objectifs de défense côtière avec ceux de la protection du milieu naturel grâce aux dunes sableuses(2017)
Subjects: 010504 meteorology & atmospheric sciences, Earthquake Source Observations, Biogeosciences, 01 natural sciences, Volcanic Effects, Global Change from Geodesy, Ionospheric Physics, Volcanic Hazards and Risks, Oceans, Sea Level Change, Earth and Planetary Sciences (miscellaneous), GE1-350, Disaster Risk Analysis and Assessment, Earthquake Interaction, Forecasting, and Prediction, QH540-549.5, General Environmental Science, Gravity Methods, climate indices, Climate and Interannual Variability, Wave climate, Seismic Cycle Related Deformations, Tectonic Deformation, Climate Impact, Earthquake Ground Motions and Engineering Seismology, Explosive Volcanism, Time Variable Gravity, Earth System Modeling, Atmospheric Processes, Seismicity and Tectonics, Ocean Monitoring with Geodetic Techniques, Ocean/Atmosphere Interactions, Mathematical Geophysics, Atmospheric, Probabilistic Forecasting, Regional Modeling, Atmospheric Effects, [SDE.MCG]Environmental Sciences/Global Changes, Volcanology, Hydrological Cycles and Budgets, Decadal Ocean Variability, Land/Atmosphere Interactions, Earthquake Dynamics, Magnetospheric Physics, Geodesy and Gravity, Global Change, wave direction, Air/Sea Interactions, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Numerical Modeling, Solid Earth, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography, Gravity anomalies and Earth structure, Geological, inshore wave climate, Ocean/Earth/atmosphere/hydrosphere/cryosphere interactions, Water Cycles, Modeling, Avalanches, Volcano Seismology, Benefit‐cost Analysis, seasonal forecasting, Computational Geophysics, Regional Climate Change, Subduction Zones, Transient Deformation, Natural Hazards, Abrupt/Rapid Climate Change, Informatics, Surface Waves and Tides, Atmospheric Composition and Structure, 010502 geochemistry & geophysics, Volcano Monitoring, long term prediction, Range (statistics), Seismology, Climatology, Exploration Geophysics, Ecology, Ocean Predictability and Prediction, Radio Oceanography, Coastal Processes, Gravity and Isostasy, Marine Geology and Geophysics, Physical Modeling, Regression, Oceanography: General, Policy, Estimation and Forecasting, Space Weather, Cryosphere, Impacts of Global Change, Oceanography: Physical, Research Article, coastal evolution, Risk, Oceanic, Theoretical Modeling, Satellite Geodesy: Results, Radio Science, Tsunamis and Storm Surges, Paleoceanography, Climate Dynamics, Ionosphere, Long-term prediction, Monitoring, Forecasting, Prediction, 0105 earth and related environmental sciences, Wave power, Numerical Solutions, Climate Change and Variability, Continental Crust, Effusive Volcanism, Climate Variability, General Circulation, Policy Sciences, Climate Impacts, Mud Volcanism, Air/Sea Constituent Fluxes, Environmental sciences, Mass Balance, Interferometry, Ocean influence of Earth rotation, 13. Climate action, Seasonal forecasting, Volcano/Climate Interactions, Environmental science, Hydrology, Prediction, Sea Level: Variations and Mean, Forecasting
Abstract: Improved understanding of how our coasts will evolve over a range of time scales (years‐decades) is critical for effective and sustainable management of coastal infrastructure. A robust knowledge of the spatial, directional and temporal variability of the inshore wave climate is required to predict future coastal evolution and hence vulnerability. However, the variability of the inshore directional wave climate has received little attention, and an improved understanding could drive development of skillful seasonal or decadal forecasts of coastal response. We examine inshore wave climate at 63 locations throughout the United Kingdom and Ireland (1980–2017) and show that 73% are directionally bimodal. We find that winter‐averaged expressions of six leading atmospheric indices are strongly correlated (r = 0.60–0.87) with both total and directional winter wave power (peak spectral wave direction) at all studied sites. Regional inshore wave climate classification through hierarchical cluster analysis and stepwise multi‐linear regression of directional wave correlations with atmospheric indices defined four spatially coherent regions. We show that combinations of indices have significant skill in predicting directional wave climates (R 2 = 0.45–0.8; p, Key Points Over 70% of inshore wave climates analyzed throughout the United Kingdom and Ireland were directionally bimodalCombinations of winter atmospheric indices NAO, WEPA, SCAND, and EA are significantly correlated with directional wave climate in all regionsRegression models using multiple winter atmospheric indices enable skillful reconstructions of directional wave climate in all regions
Published: 2021
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48. Antagonistic cytoprotective effects of C60 fullerene nanoparticles in simultaneous exposure to benzo[a]pyrene in a molluscan animal model

Author: Volker M. Arlt, Aldo Viarengo, Yann Aminot, Awadhesh N. Jha, Susanna Sforzini, Andrei N. Khlobystov, Mohamed Banni, Michael N Moore, James W. Readman, Audrey Barranger, Plymouth University, University of Exeter Medical School, University of Exeter, Plymouth Marine Laboratory (PML), Plymouth Marine Laboratory, Consiglio Nazionale delle Ricerche (CNR), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut Français de Recherche pour l'Exploitation de la Mer - Brest (IFREMER Centre de Bretagne), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), University of Nottingham, UK (UON), King‘s College London, Institut Salah Azaiz [Tunis] (ISA), and Natural Environment Research Council (NERC), UK UK Research and Innovation (UKRI) NERC Natural Environment Research Council [NE/L006782/1]
Subjects: Environmental Engineering, animal structures, 010504 meteorology & atmospheric sciences, Membrane permeability, Cell, mTORC1, Oxidative phosphorylation, 010501 environmental sciences, 01 natural sciences, Lipofuscin, chemistry.chemical_compound, medicine, polycyclic compounds, Autophagy, Environmental Chemistry, Oxidative-injury, Waste Management and Disposal, 0105 earth and related environmental sciences, chemistry.chemical_classification, Antagonism, Reactive oxygen species, Chemistry, Complexity, Pollution, C-60-nanoparticles, Cytosol, medicine.anatomical_structure, Biochemistry, Benzo(a)pyrene, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Lysosomes
Abstract: International audience; The hypothesis that C fullerene nanoparticles (C) exert an antagonistic interactive effect on the toxicity of benzo[a]pyrene (BaP) has been supported by this investigation. Mussels were exposed to BaP (5, 50 & 100μg/L) and C (C-1mg/L) separately and in combination. Both BaP and C were shown to co-localize in the secondary lysosomes of the hepatopancreatic digestive cells in the digestive gland where they reduced lysosomal membrane stability (LMS) or increased membrane permeability, while BaP also induced increased lysosomal lipid and lipofuscin, indicative of oxidative cell injury and autophagic dysfunction. Combinations of BaP and C showed antagonistic effects for lysosomal stability, mTORC1 (mechanistic target of rapamycin complex 1) inhibition and intralysosomal lipid (5 & 50μg/L BaP). The biomarker data (i.e., LMS, lysosomal lipidosis and lipofuscin accumulation; lysosomal/cell volume and dephosphorylation of mTORC1) were further analysed using multivariate statistics. Principal component and cluster analysis clearly indicated that BaP on its own was more injurious than in combination with C. Use of a network model that integrated the biomarker data for the cell pathophysiological processes, indicated that there were significant antagonistic interactions in network complexity (% connectance) at all BaP concentrations for the combined treatments. Loss of lysosomal membrane stability probably causes the release of intralysosomal iron and hydrolases into the cytosol, where iron can generate harmful reactive oxygen species (ROS). It was inferred that this adverse oxidative reaction induced by BaP was ameliorated in the combination treatments by the ROS scavenging property of intralysosomal C, thus limiting the injury to the lysosomal membrane; and reducing the oxidative damage in the cytosol and to the nuclear DNA. The ROS scavenging by C, in combination with enhanced autophagic turnover of damaged cell constituents, appeared to have a cytoprotective effect against the toxic reaction to BaP in the combined treatments.
Published: 2021
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49. A 3D In Vitro Model of the Human Airway Epithelium Exposed to Tritiated Water: Dosimetric Estimate and Cytotoxic Effects

Author: Bernard Rousseau, Andrea Ottolenghi, Thierry Orsière, Giorgio Baiocco, Yordenca Lamartinière, Sébastien Garcia-Argote, Leonardo Lonati, Véronique Malard, Christian Grisolia, Awadhesh N. Jha, Isabella Guardamagna, Laurence Lebaron-Jacobs, Isabelle George, Laboratory of Radiation Biophysics and Radiobiology, Department of Physics, University of Pavia, Pavia, Italy, Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), School of Biological and Marine Sciences, University of Plymouth, Plymouth, United Kingdom, Aix Marseille University, CEA, CNRS, BIAM, Saint Paul-Lez-Durance, France., Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Università degli Studi di Pavia = University of Pavia (UNIPV), Plymouth University, Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: Tritiated water, Biophysics, Context (language use), [SDV.CAN]Life Sciences [q-bio]/Cancer, Absorption (skin), Tritium, Epithelium, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, Viability assay, Radiometry, Lung, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Radiation, Chemistry, Cumulative dose, Water, Tritiated Water, [SDE.ES]Environmental Sciences/Environmental and Society, 3. Good health, Human Airway Epithelium, medicine.anatomical_structure, 13. Climate action, Cytotoxic Effects, 030220 oncology & carcinogenesis, Animal studies, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, 3D In Vitro Model
Abstract: International audience; Tritium has been receiving worldwide attention, particularly because of its production and use in existing fission reactors and future nuclear fusion technologies, leading to an increased risk of release in the environment. Linking human health effects to low-dose tritium exposures presents a challenge for many reasons. Among these: biological effects strongly depend on the speciation of tritiated products and exposure pathway; large dosimetric uncertainties may exist; measurements using in vitro cell cultures generally lack a description of effects at the tissue level, while large-scale animal studies might be ethically questionable and too highly demanding in terms of resources. In this context, threedimensional models of the human airway epithelium are a powerful tool to investigate potential toxicity induced upon inhalation of radioactive products in controlled physiological conditions. In this study we exposed such a model to tritiated water (HTO) for 24 h, with a range of activity levels (up to ;33 kBq ll–1 cm–2). After the exposures, we measured cell viability, integrity of epithelial layer and pro-inflammatoryresponse at different post-exposure time-points. We also quantified tritium absorption and performed dosimetric estimates considering HTO passage through the epithelial layer, leading to reconstructed upper limits for the dose to the tissue of less than 50 cGy cumulative dose for the highest activity. Upon exposure to the highest activity, cell viability was not decreased; however, we observed a small effect on epithelial integrity and an inflammatory response persisting after seven days. These results represent a reference condition and will guide future experiments using human airway epithelium to investigate the effects of other peculiar tritiated products.
Published: 2021
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50. Role of silicon in the development of complex crystal shapes in coccolithophores

Author: Charlotte E. Walker, Glenn M. Harper, Alison Taylor, Erin M. Meyer, Oz Ben Joseph, Assaf Gal, Glen L. Wheeler, Colin Brownlee, Ian Probert, Gerald Langer, Marine Biological Association, University of North Carolina [Wilmington] (UNC), University of North Carolina System (UNC), Weizmann Institute of Science [Rehovot, Israël], Plymouth University, Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and University of Southampton
Subjects: 0106 biological sciences, 0301 basic medicine, Silicon, Physiology, Coccolithophore, [SDV]Life Sciences [q-bio], Morphogenesis, chemistry.chemical_element, Plant Science, 01 natural sciences, Calcium Carbonate, Carbon Cycle, Coccolith, Crystal, calcification, 03 medical and health sciences, Calcification, Physiologic, evolution, coccolithophore, 14. Life underwater, biology, Chemistry, Haptophyta, silicon, biology.organism_classification, biomineralization, 030104 developmental biology, Biophysics, 010606 plant biology & botany, Biomineralization, coccolith
Abstract: International audience; The development of calcification by the coccolithophores had a profound impact on ocean carbon cycling, but the evolutionary steps leading to the formation of these complex biomineralized structures are not clear. Heterococcoliths consisting of intricately shaped calcite crystals are formed intracellularly by the diploid life cycle phase. Holococcoliths consisting of simple rhombic crystals can be produced by the haploid life cycle stage but are thought to be formed extracellularly, representing an independent evolutionary origin of calcification. We use advanced microscopy techniques to determine the nature of coccolith formation and complex crystal formation in coccolithophore life cycle stages. We find that holococcoliths are formed in intracellular compartments in a similar manner to heterococcoliths. However, we show that silicon is not required for holococcolith formation and that the requirement for silicon in certain coccolithophore species relates specifically to the process of crystal morphogenesis in heterococcoliths. We therefore propose an evolutionary scheme in which the lower complexity holococcoliths represent an ancestral form of calcification in coccolithophores. The subsequent recruitment of a silicon-dependent mechanism for crystal morphogenesis in the diploid life cycle stage led to the emergence of the intricately shaped heterococcoliths, enabling the formation of the elaborate coccospheres that underpin the ecological success of coccolithophores.
Published: 2021
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