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1. Endovascular Therapy or Medical Management Alone for Isolated Posterior Cerebral Artery Occlusion: A Multicenter Study

Author

Sabben, Candice, Charbonneau, Frédérique, Delvoye, François, Strambo, Davide, Heldner, Mirjam R., Ong, Elodie, Ter Schiphorst, Adrien, Henon, Hilde, Ben Hassen, Wagih, Agasse-Lafont, Thomas, Legris, Loïc, Sibon, Igor, Wolff, Valérie, Sablot, Denis, Elhorany, Mahmoud, Preterre, Cécile, Nehme, Nour, Soize, Sébastien, Weisenburger-Lile, David, Triquenot-Bagan, Aude, Mione, Gioia, Aignatoaie, Andreea, Papassin, Jérémie, Poll, Roxana, Béjot, Yannick, Carrera, Emmanuel, Garnier, Pierre, Michel, Patrik, Saliou, Guillaume, Mordasini, Pasquale, Berthezene, Yves, Costalat, Vincent, Bricout, Nicolas, Albers, Gregory W., Mazighi, Mikael, Turc, Guillaume, Seners, Pierre, Antonenko, Kateryna, Arquizan, Caroline, Benammar, Lynda, Boutet, Claire, Clarençon, Frédéric, Comby, Pierre-Olivier, Desal, Hubert, Detante, Olivier, Eugene, François, Gerardin, Emmanuel, Gory, Benjamin, Kremer, Stéphane, Ledure, Sylvain, Krug, Mathieu, Lapergue, Bertrand, Niclot, Philippe, Magni, Christophe, Obadia, Michael, Ozsancak, Canan, Pico, Fernando, Pilgram-Pastor, Sara, Pop, Raoul, Richard, Sébastien, Rosso, Charlotte, Savatovsky, Julien, Moulin, Solène, Tracol, Clément, and Zbinden, Martin

Published
2023
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2. Baseline characteristics and outcome of stroke patients after endovascular therapy according to previous symptomatic vascular disease and sex

Author

Peycheva, Marieta, primary, Padlina, Giovanna, additional, Genceviciute, Kotryna, additional, Krasteva, Marina P., additional, Boronylo, Anna, additional, Goeldlin, Martina B., additional, Müller, Madlaine, additional, Wenz, Elena S., additional, Müller, Mandy D., additional, Hammer, Helly, additional, Bücke, Philipp, additional, Bigi, Sandra, additional, Simonetti, Barbara Goeggel, additional, Hoffmann, Angelika, additional, Umarova, Roza M., additional, Pilgram-Pastor, Sara, additional, Gralla, Jan, additional, Mordasini, Pasquale, additional, Antonenko, Kateryna, additional, and Heldner, Mirjam R., additional

Published
2024
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3. Value of Immediate Flat Panel Perfusion Imaging after Endovascular Therapy (AFTERMATH): A Proof of Concept Study

Author

Mujanovic, Adnan, primary, Kurmann, Christoph C., additional, Manhart, Michael, additional, Piechowiak, Eike I., additional, Pilgram-Pastor, Sara M., additional, Serrallach, Bettina L., additional, Boulouis, Gregoire, additional, Meinel, Thomas R., additional, Seiffge, David J., additional, Jung, Simon, additional, Arnold, Marcel, additional, Nguyen, Thanh N., additional, Fischer, Urs, additional, Gralla, Jan, additional, Dobrocky, Tomas, additional, Mordasini, Pasquale, additional, and Kaesmacher, Johannes, additional

Published
2024
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4. Abstract 034: Value of Immediate Flat Panel Perfusion Imaging After Endovascular Therapy: A proof of concept study

Author

Mujanovic, Adnan, primary, Kurmann, Christoph, additional, Manhart, Michael, additional, Piechowiak, Eike, additional, Pilgram‐Pastor, Sara, additional, Serrallach, Bettina, additional, Boulouis, Gregoire, additional, Meinel, Thomas, additional, Seiffge, David, additional, Jung, Simon, additional, Arnold, Marcel, additional, Nguyen, Thanh, additional, Fischer, Urs, additional, Gralla, Jan, additional, Dobrocky, Tomas, additional, Mordasini, Pasquale, additional, and Kaesmacher, Johannes, additional

Published
2023
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6. Absence of susceptibility vessel sign and hyperdense vessel sign in patients with cancer-related stroke

Author

Beyeler, Morin, Grunder, Lorenz, Göcmen, Jayan, Steinauer, Fabienne, Belachew, Nebiyat F, Kielkopf, Moritz, Clénin, Leander, Mueller, Madlaine, Silimon, Norbert, Kurmann, Christoph, Meinel, Thomas, Bücke, Philipp, Seiffge, David Julian, Dobrocky, Tomas, Piechowiak, Eike I, Pilgram-Pastor, Sara, Mattle, Heinrich P, Navi, Babak B, Arnold, Marcel, Fischer, Urs, Pabst, Thomas, Gralla, Jan, Berger, Martin D, Jung, Simon, and Kaesmacher, Johannes

Subjects
Neurology, 610 Medicine & health, Neurology (clinical)
Abstract

Background and aimIdentification of paraneoplastic hypercoagulability in stroke patients helps to guide investigations and prevent stroke recurrence. A previous study demonstrated an association between the absence of the susceptibility vessel sign (SVS) on brain MRI and active cancer in patients treated with mechanical thrombectomy. The present study aimed to confirm this finding and assess an association between the absence of the hyperdense vessel sign (HVS) on head CT and active cancer in all stroke patients.MethodsSVS and HVS status on baseline imaging were retrospectively assessed in all consecutive stroke patients treated at a comprehensive stroke center between 2015 and 2020. Active cancer, known at the time of stroke or diagnosed within 1 year after stroke (occult cancer), was identified. Adjusted odds ratios (aOR) and their 95% confidence interval (CI) for the association between the thrombus imaging characteristics and cancer were calculated using multivariable logistic regression.ResultsOf the 2,256 patients with thrombus imaging characteristics available at baseline, 161 had an active cancer (7.1%), of which 36 were occult at the time of index stroke (1.6% of the total). The absence of SVS was associated with active cancer (aOR 3.14, 95% CI 1.45–6.80). No significance was reached for the subgroup of occult cancer (aOR 3.20, 95% CI 0.73–13.94). No association was found between the absence of HVS and active cancer (aOR 1.07, 95% CI 0.54–2.11).ConclusionThe absence of SVS but not HVS could help to identify paraneoplastic hypercoagulability in stroke patients with active cancer and guide patient care.

Published
2023
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7. Benefit of Advanced 3D DSA and MRI/CT Fusion in Neurovascular Pathology

Author

Dobrocky, Tomas, Matzinger, Marco, Piechowiak, Eike I, Kaesmacher, Johannes, Pilgram-Pastor, Sara, Goldberg, Johannes, Bervini, David, Klail, Tomas, Pereira, Vitor Mendes, Z'Graggen, Werner, Raabe, Andreas, Mordasini, Pasquale, and Gralla, Jan

Subjects
610 Medicine & health, Radiology, Nuclear Medicine and imaging, Neurology (clinical), 610 Medizin und Gesundheit
Abstract

Digital subtraction angiography provides excellent spatial and temporal resolution; however, it lacks the capability to depict the nonvascular anatomy of the brain and spinal cord.A review of the institutional database identified five patients in whom a new integrated fusion workflow of cross-sectional imaging and 3D rotational angiography (3DRA) provided important diagnostic information and assisted in treatment planning. These included two acutely ruptured brain arteriovenous malformations (AVM), a small superficial brainstem AVM after radiosurgery, a thalamic microaneurysm, and a spine AVM, and fusion was crucial for diagnosis and influenced further treatment.Fusion of 3DRA and cross-sectional imaging may help to gain a deeper understanding of neurovascular diseases. This is advantageous for planning and providing treatment and, most importantly, may harbor the potential to minimize complication rates. Integrating image fusion in the work-up of cerebrovascular diseases is likely to have a major impact on the neurovascular field in the future.

Published
2023
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8. sj-docx-1-eso-10.1177_23969873231164274 – Supplemental material for Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy

Author

Mujanovic, Adnan, Brigger, Robin, Kurmann, Christoph C, Ng, Felix, Branca, Mattia, Dobrocky, Tomas, Meinel, Thomas R, Windecker, Daniel, Almiri, William, Grunder, Lorenz, Beyeler, Morin, Seiffge, David J, Pilgram-Pastor, Sara, Arnold, Marcel, Piechowiak, Eike I, Campbell, Bruce, Gralla, Jan, Fischer, Urs, and Kaesmacher, Johannes

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873231164274 for Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy by Adnan Mujanovic, Robin Brigger, Christoph C Kurmann, Felix Ng, Mattia Branca, Tomas Dobrocky, Thomas R Meinel, Daniel Windecker, William Almiri, Lorenz Grunder, Morin Beyeler, David J Seiffge, Sara Pilgram-Pastor, Marcel Arnold, Eike I Piechowiak, Bruce Campbell, Jan Gralla, Urs Fischer and Johannes Kaesmacher in European Stroke Journal

Published
2023
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9. sj-pdf-2-eso-10.1177_23969873231164274 – Supplemental material for Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy

Author

Mujanovic, Adnan, Brigger, Robin, Kurmann, Christoph C, Ng, Felix, Branca, Mattia, Dobrocky, Tomas, Meinel, Thomas R, Windecker, Daniel, Almiri, William, Grunder, Lorenz, Beyeler, Morin, Seiffge, David J, Pilgram-Pastor, Sara, Arnold, Marcel, Piechowiak, Eike I, Campbell, Bruce, Gralla, Jan, Fischer, Urs, and Kaesmacher, Johannes

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-2-eso-10.1177_23969873231164274 for Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy by Adnan Mujanovic, Robin Brigger, Christoph C Kurmann, Felix Ng, Mattia Branca, Tomas Dobrocky, Thomas R Meinel, Daniel Windecker, William Almiri, Lorenz Grunder, Morin Beyeler, David J Seiffge, Sara Pilgram-Pastor, Marcel Arnold, Eike I Piechowiak, Bruce Campbell, Jan Gralla, Urs Fischer and Johannes Kaesmacher in European Stroke Journal

Published
2023
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10. Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy

Author

Mujanovic, Adnan, primary, Brigger, Robin, additional, Kurmann, Christoph C, additional, Ng, Felix, additional, Branca, Mattia, additional, Dobrocky, Tomas, additional, Meinel, Thomas R, additional, Windecker, Daniel, additional, Almiri, William, additional, Grunder, Lorenz, additional, Beyeler, Morin, additional, Seiffge, David J, additional, Pilgram-Pastor, Sara, additional, Arnold, Marcel, additional, Piechowiak, Eike I, additional, Campbell, Bruce, additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2023
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11. Abstract Number ‐ 184: Prediction Model For Medical Rescue Treatment Strategies In Patients With Incomplete Reperfusion

Author

Mujanovic, Adnan, primary, Kurmann, Christoph, additional, Dobrocky, Tomas, additional, Meinel, Thomas, additional, Grunder, Lorenz, additional, Beyeler, Morin, additional, Lang, Matthias F, additional, Jung, Simon, additional, Klail, Tomas, additional, Hoffmann, Angelika, additional, Seiffge, David J, additional, Heldner, Mirjam, additional, Pilgram‐Pastor, Sara, additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Piechowiak, Eike I, additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2023
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12. Abstract TMP3: Prediction Model For Medical Rescue Treatment Strategies In Patients With Incomplete Reperfusion

Author

Mujanovic, Adnan, primary, Kurmann, Christoph, additional, Dobrocky, Tomas, additional, Meinel, Thomas, additional, Almiri, William, additional, Grunder, Lorenz, additional, Beyeler, Morin, additional, Lang, Matthias, additional, Jung, Simon, additional, Klail, Tomas, additional, Hoffmann, Angelika, additional, Seiffge, David, additional, Heldner, Mirjam, additional, Pilgram-Pastor, Sara, additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Piechowiak, Eike, additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2023
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13. Should Patients With Acute Minor Ischemic Stroke With Isolated Internal Carotid Artery Occlusion Be Thrombolysed?

Author

Boulenoir, Naouel, primary, Turc, Guillaume, additional, Ter Schiphorst, Adrien, additional, Heldner, Mirjam R., additional, Strambo, Davide, additional, Laksiri, Nadia, additional, Girard Buttaz, Isabelle, additional, Papassin, Jérémie, additional, Sibon, Igor, additional, Chausson, Nicolas, additional, Michel, Patrik, additional, Rosso, Charlotte, additional, Bourdain, Frédéric, additional, Lamy, Chantal, additional, Weisenburger-Lile, David, additional, Agius, Pierre, additional, Yger, Marion, additional, Obadia, Michael, additional, Sablot, Denis, additional, Legris, Nicolas, additional, Jung, Simon, additional, Pilgram-Pastor, Sara, additional, Henon, Hilde, additional, Bernardaud, Lucy, additional, Arquizan, Caroline, additional, Baron, Jean-Claude, additional, Seners, Pierre, additional, Ben Hassen, Wagih, additional, Lapergue, Bertrand, additional, Lucas, Ludovic, additional, Leys, Didier, additional, Philippeau, Frédéric, additional, Bennani, Omar, additional, Mechtouff, Laura, additional, Klapczynski, Frédéric, additional, Detante, Olivier, additional, Costalat, Vincent, additional, Mione, Gioia, additional, Gazzola, Sébastien, additional, Debiais, Séverine, additional, Cakmak, Serkan, additional, Grigoras, Valer, additional, Denier, Christian, additional, Smadja, Didier, additional, Mounier-Vehier, François, additional, Peres, Roxane, additional, Spelle, Laurent, additional, Bricout, Nicolas, additional, Bracard, Serge, additional, Triquenot, Aude, additional, Lyoubi, Aïcha, additional, Cottier, Jean-Philippe, additional, Duong, Duc-Long, additional, and Ollivier, Camille, additional

Published
2022
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14. Importance of Delayed Reperfusions in Patients With Incomplete Thrombectomy

Author

Mujanovic, Adnan, primary, Jungi, Noel, additional, Kurmann, Christoph C., additional, Dobrocky, Tomas, additional, Meinel, Thomas R., additional, Almiri, William, additional, Grunder, Lorenz, additional, Beyeler, Morin, additional, Lang, Matthias F., additional, Jung, Simon, additional, Klail, Tomas, additional, Hoffmann, Angelika, additional, Seiffge, David J., additional, Heldner, Mirjam R., additional, Pilgram-Pastor, Sara, additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Piechowiak, Eike I., additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2022
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15. Absence of Susceptibility Vessel Sign in Patients With Malignancy-Related Acute Ischemic Stroke Treated With Mechanical Thrombectomy

Author

Beyeler, Morin, primary, Belachew, Nebiyat F., additional, Kielkopf, Moritz, additional, Aleman, Enrique B., additional, León Betancourt, Alejandro Xavier, additional, Genceviciute, Kotryna, additional, Kurmann, Christoph, additional, Grunder, Lorenz, additional, Birner, Barbara, additional, Meinel, Thomas R., additional, Scutelnic, Adrian, additional, Bücke, Philipp, additional, Seiffge, David J., additional, Dobrocky, Tomas, additional, Piechowiak, Eike I., additional, Pilgram-Pastor, Sara, additional, Mattle, Heinrich P., additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Fischer, Urs, additional, Pabst, Thomas, additional, Gralla, Jan, additional, Berger, Martin D., additional, Jung, Simon, additional, and Kaesmacher, Johannes, additional

Published
2022
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16. Long‐Term Outcome and Quality of Life in Patients With Stroke Presenting With Extensive Early Infarction

Author

Beyeler, Morin, primary, Weber, Loris, additional, Buffle, Eric, additional, Kurmann, Christoph C., additional, Piechowiak, Eike Immo, additional, Branca, Mattia, additional, Meinel, Thomas Raphael, additional, Jung, Simon, additional, Seiffge, David, additional, Heldner, Mirjam R., additional, Pilgram‐Pastor, Sara M., additional, Dobrocky, Tomas, additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2022
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18. Stroke and splenic infarct in a 17-year-old patient with COVID-associated hypercoagulable state and relative ADAMTS13 deficiency

Author

Pistor, Maximilian, Hoffmann, Angelika, Horvath, Thomas, Oberholzer, Michael, Arnold, Marcel, and Pilgram-Pastor, Sara Magdalena

Subjects
Stroke, endovascular therapy, SARS-CoV2, hypercoagulable state, young stroke, COVID-19, 610 Medicine & health, Neurosciences. Biological psychiatry. Neuropsychiatry, cardiovascular diseases, ADAMTS13, COVID, RC321-571
Abstract

In this case report, we present the case of a 17-year-old stroke patient suffering from coronavirus disease (COVID)-19. He was successfully treated with intravenous and endovascular treatment. After extensive work-up, a hypercoagulable state due to the COVID-19 infection was assumed as probable cause of stroke.

Published
2021
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21. In-Hospital Complication Rates After Stent Treatment of 388 Symptomatic Intracranial Stenoses: Results From the INTRASTENT Multicentric Registry

Author

Kurre, Wiebke, Berkefeld, Joachim, Brassel, Friedhelm, Brüning, Roland, Eckert, Bernd, Kamek, Seniye, Klein, Guenther E., Knauth, Michael, Liebig, Thomas, Maskova, Jana, Mucha, Dirk, Neumann-Haefelin, Tobias, Pilgram-Pastor, Sara, Sitzer, Matthias, Sonnberger, Michael, Tietke, Mark, Trenkler, Johannes, and Turowski, Bernd

Published
2010
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22. Basilar Artery Perforator Aneurysms – The Phantom Menace of the Intracranial Universe

Author

Klail, Tomas, Pilgram-Pastor, Sara, Serrallach, Bettina, Noti, Luca, Raabe, Max, Bervini, David, Goldberg, Johannes, Kaesmacher, Johannes, Piechowiak, Eike I, Z’Graggen, Werner, Gralla, Jan, and Dobrocky, Tomas

Abstract

Cerebral perforators are end-arteries that vascularize specific deep territories in the cerebral hemispheres and brainstem. Due to improved imaging quality, these aneurysms are increasingly diagnosed in clinical routine. High resolution 3D angiographic images are mandatory and in some occasions fusion images might be helpful to detect these aneurysms. Basilar artery perforator aneurysms (or BAPAs) are one of the most common subtypes of perforator aneurysms and might cause subarachnoid hemorrhage along the brainstem (perimesencephalic hemorrhage). Due to the limited evidence, the management of BAPAs may pose a challenge in clinical routine. While some aneurysms can be managed conservatively, a few might require treatment to prevent rebleeding. We present the cases of two patients with BAPAs managed at our center in order to increase the awareness on these potentially underdiagnosed aneurysms.

Published
2024
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24. Value of Immediate Flat Panel Perfusion Imaging after Endovascular Therapy (AFTERMATH): A Proof of Concept Study.

Author

Mujanovic A, Kurmann CC, Manhart M, Piechowiak EI, Pilgram-Pastor SM, Serrallach BL, Boulouis G, Meinel TR, Seiffge DJ, Jung S, Arnold M, Nguyen TN, Fischer U, Gralla J, Dobrocky T, Mordasini P, and Kaesmacher J

Subjects
Humans, Proof of Concept Study, Tomography, X-Ray Computed methods, Thrombectomy, Perfusion Imaging, Treatment Outcome, Stroke diagnostic imaging, Stroke surgery, Endovascular Procedures, Brain Ischemia
Abstract

Background and Purpose: Potential utility of flat panel CT perfusion imaging (FPCT-PI) performed immediately after mechanical thrombectomy (MT) is unknown. We aimed to assess whether FPCT-PI obtained directly post-MT could provide additional potentially relevant information on tissue reperfusion status., Materials and Methods: This was a single-center analysis of all patients with consecutive acute stroke admitted between June 2019 and March 2021 who underwent MT and postinterventional FPCT-PI ( n  = 26). A core lab blinded to technical details and clinical data performed TICI grading on postinterventional DSA images and qualitatively assessed reperfusion on time-sensitive FPCT-PI maps. According to agreement between DSA and FPCT-PI, all patients were classified into 4 groups: hypoperfusion findings perfectly matched by location (group 1), hypoperfusion findings mismatched by location (group 2), complete reperfusion on DSA with hypoperfusion on FPCT-PI (group 3), and hypoperfusion on DSA with complete reperfusion on FPCT-PI (group 4)., Results: Detection of hypoperfusion (present/absent) concurred in 21/26 patients. Of these, reperfusion findings showed perfect agreement on location and size in 16 patients (group 1), while in 5 patients there was a mismatch by location (group 2). Of the remaining 5 patients with disagreement regarding the presence or absence of hypoperfusion, 3 were classified into group 3 and 2 into group 4. FPCT-PI findings could have avoided TICI overestimation in all false-positive operator-rated TICI 3 cases (10/26)., Conclusions: FPCT-PI may provide additional clinically relevant information in a considerable proportion of patients undergoing MT. Hence, FPCT-PI may complement the evaluation of reperfusion efficacy and potentially inform decision-making in the angiography suite., (© 2024 by American Journal of Neuroradiology.)

Published
2024
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