1. Optical coherence tomography angiography analysis of macular flow density in glaucoma
- Author
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Bernd Junker, Carsten Framme, Robert Kromer, Amelie Pielen, and Philipp Glusa
- Subjects
Male ,medicine.medical_specialty ,genetic structures ,Fundus Oculi ,Optic Disk ,Flow density ,Glaucoma ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Nerve Fibers ,Ophthalmology ,Medicine ,Humans ,Macula Lutea ,Prospective Studies ,Fluorescein Angiography ,Aged ,Retina ,Plexus ,business.industry ,Significant difference ,Retinal Vessels ,Retinal ,General Medicine ,Optical coherence tomography angiography ,Blood flow ,medicine.disease ,eye diseases ,medicine.anatomical_structure ,chemistry ,030221 ophthalmology & optometry ,Visual Field Tests ,Female ,sense organs ,Visual Fields ,business ,030217 neurology & neurosurgery ,Blood Flow Velocity ,Glaucoma, Open-Angle ,Tomography, Optical Coherence ,Follow-Up Studies - Abstract
PURPOSE Modifications in ocular blood flow may play a significant role in glaucoma development. Optical coherence tomography angiography (OCT-A) is based on the detection and analysis of the reflection behaviour of motion in a static environment and therefore is able to quantify the retinal flow density. We used this new technology to examine the density of the active flow vasculature in the macular area in glaucoma patients compared to healthy patients. METHODS Thirty patients with primary open-angle glaucoma (mean age: 72.6 ± 7.1 years) and 21 healthy patients (mean age: 70.3 ± 8.6 years) were recruited. Patients received perimetry and OCT measurements of the peripapillary retinal nerve fibre layer thickness (RNFLT) and macular retinal thickness and OCT-A of the macular area in the superficial and deep retinal (DR) plexus. Flow density of the OCT-A scan was calculated by binarisation and quantification of the pixel density. RESULTS Macular flow density was globally and nasally reduced in glaucoma patients in the superficial (globally: p = 0.0203; nasally: p = 0.0003) and DR plexus (globally: p = 0.0113, nasally: p
- Published
- 2017