21 results on '"Petrone, Luisa"'
Search Results
2. Early calcitonin levels in medullary thyroid carcinoma: Prognostic role in patients without distant metastases at diagnosis
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Sparano, Clotilde, primary, Adornato, Virginia, additional, Puccioni, Matteo, additional, Zago, Elena, additional, Perigli, Giuliano, additional, Badii, Benedetta, additional, Santoro, Roberto, additional, Maggi, Mario, additional, and Petrone, Luisa, additional
- Published
- 2023
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- View/download PDF
3. Classic and Follicular Variant of Papillary Thyroid Microcarcinoma: 2 Different Phenotypes Beyond Tumor Size
- Author
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Sparano, Clotilde, primary, Rotondi, Mario, additional, Verdiani, Valentina, additional, Brunori, Paolo, additional, Castiglione, Francesca, additional, Bartoli, Caterina, additional, Perigli, Giuliano, additional, Badii, Benedetta, additional, Vezzosi, Vania, additional, Simontacchi, Gabriele, additional, Livi, Lorenzo, additional, Antonuzzo, Lorenzo, additional, Maggi, Mario, additional, and Petrone, Luisa, additional
- Published
- 2022
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- View/download PDF
4. Gastric Th17 Cells Specific for H+/K+-ATPase and Serum IL-17 Signature in Gastric Autoimmunity
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Della Bella, Chiara, Antico, Antonio, Panozzo, Maria Piera, Capitani, Nagaja, Petrone, Luisa, Benagiano, Marisa, D’Elios, Sofia, Sparano, Clotilde, Azzurri, Annalisa, Pratesi, Sara, Cianchi, Fabio, Ortiz-Princz, Diana, Bergman, Mathijs, Bizzaro, Nicola, D’Elios, Mario Milco, Molecular Microbiology, and AIMMS
- Subjects
Adenosine Triphosphatases ,gastric autoimmunity ,gastric cancer ,Interleukin-17 ,serum IL-17 ,Immunology ,T cells ,Autoimmunity ,gastric autoantigen ,H+/K+-ATPase ,Th17 ,gastric mucosal immunity ,Cytokines ,Gastric Mucosa ,H(+)-K(+)-Exchanging ATPase ,Humans ,Gastritis ,Th17 Cells ,SDG 3 - Good Health and Well-being ,Immunology and Allergy ,H/K-ATPase - Abstract
Human gastric autoimmunity [autoimmune gastritis (AIG)] is characterized by inflammation of the gastric mucosa and parietal cell loss. The gastric parietal cell proton pump H+/K+-adenosine triphosphatase (H+/K+-ATPase) is the major autoantigen in AIG. Our work aimed to investigate the gastric H+/K+-ATPase-specific T helper 17 (Th17) responses in AIG and serum interleukin (IL)-17 cytokine subfamily in AIG patients, in healthy subjects [healthy controls (HCs)], and in patients with iron deficiency anemia (IDA) without AIG. We analyzed the activation of gastric lamina propria mononuclear cells (LPMCs) by H+/K+-ATPase and the IL-17A and IL-17F cytokine production in eight patients with AIG and four HCs. Furthermore, we compared serum levels of IL-17A, IL-17F, IL-21, IL-17E, IL-22, and IL-23 in 43 AIG patients, in 47 HCs, and in 20 IDA patients without AIG. Gastric LPMCs from all AIG patients, but not those from HCs, were activated by H+/K+-ATPase and were able to proliferate and produce high levels of IL-17A and IL-17F. AIG patients have significantly higher serum IL-17A, IL-17F, IL-21, and IL-17E (393.3 ± 410.02 pg/ml, 394.0 ± 378.03 pg/ml, 300.46 ± 303.45 pg/ml, 34.92 ± 32.56 pg/ml, respectively) than those in HCs (222.99 ± 361.24 pg/ml, 217.49 ± 312.1 pg/ml, 147.43 ± 259.17 pg/ml, 8.69 ± 8.98 pg/ml, respectively) and those in IDA patients without AIG (58.06 ± 107.49 pg/ml, 74.26 ± 178.50 pg/ml, 96.86 ± 177.46 pg/ml, 10.64 ± 17.70 pg/ml, respectively). Altogether, our results indicate that IL-17A and IL-17F are produced in vivo in the stomach of AIG patients following activation with H+/K+-ATPase and that serum IL-17A, IL-17F, IL-21, and IL-17E levels are significantly elevated in AIG patients but not in patients without AIG. These data suggest a Th17 signature in AIG and that IL-17A, IL-17F, IL-21, and IL-17E may represent a relevant tool for AIG management.
- Published
- 2022
5. Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis
- Author
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Della Bella, Chiara, primary, Antico, Antonio, additional, Panozzo, Maria Piera, additional, Capitani, Nagaja, additional, Benagiano, Marisa, additional, Petrone, Luisa, additional, Azzurri, Annalisa, additional, Pratesi, Sara, additional, D’Elios, Sofia, additional, Cianchi, Fabio, additional, Ortiz-Princz, Diana, additional, Bizzaro, Nicola, additional, and D’Elios, Mario Milco, additional
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- 2022
- Full Text
- View/download PDF
6. Thyroidectomy for Cancer: The Surgeon and the Parathyroid Glands Sparing
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Perigli, Giuliano, primary, Cianchi, Fabio, additional, Giudici, Francesco, additional, Russo, Edda, additional, Fiorenza, Giulia, additional, Petrone, Luisa, additional, Sparano, Clotilde, additional, Staderini, Fabio, additional, Badii, Benedetta, additional, and Morandi, Alessio, additional
- Published
- 2021
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- View/download PDF
7. Gastric Th17 Cells Specific for H+ /K+- ATPase and Serum IL-17 Signature in Gastric Autoimmunity.
- Author
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Bella, Chiara Della, Antico, Antonio, Panozzo, Maria Piera, Capitani, Nagaja, Petrone, Luisa, Benagiano, Marisa, D’Elios, Sofia, Sparano, Clotilde, Azzurri, Annalisa, Pratesi, Sara, Cianchi, Fabio, Ortiz-Princz, Diana, Bergman, Mathijs, Bizzaro, Nicola, and D’Elios, Mario Milco
- Abstract
Human gastric autoimmunity [autoimmune gastritis (AIG)] is characterized by inflammation of the gastric mucosa and parietal cell loss. The gastric parietal cell proton pump H
+ /K+ - adenosine triphosphatase (H+ /K+ -ATPase) is the major autoantigen in AIG. Our work aimed to investigate the gastric H+ /K+ -ATPase-specific T helper 17 (Th17) responses in AIG and serum interleukin (IL)-17 cytokine subfamily in AIG patients, in healthy subjects [healthy controls (HCs)], and in patients with iron deficiency anemia (IDA) without AIG. We analyzed the activation of gastric lamina propria mononuclear cells (LPMCs) by H+ /K+ -ATPase and the IL17A and IL-17F cytokine production in eight patients with AIG and four HCs. Furthermore, we compared serum levels of IL-17A, IL-17F, IL-21, IL-17E, IL-22, and IL-23 in 43 AIG patients, in 47 HCs, and in 20 IDA patients without AIG. Gastric LPMCs from all AIG patients, but not those from HCs, were activated by H+ /K+ -ATPase and were able to proliferate and produce high levels of IL-17A and IL-17F. AIG patients have significantly higher serum IL-17A, IL-17F, IL-21, and IL-17E (393.3 ± 410.02 pg/ml, 394.0 ± 378.03 pg/ml, 300.46 ± 303.45 pg/ml, 34.92 ± 32.56 pg/ml, respectively) than those in HCs (222.99 ± 361.24 pg/ml, 217.49 ± 312.1 pg/ml, 147.43 ± 259.17 pg/ml, 8.69 ± 8.98 pg/ml, respectively) and those in IDA patients without AIG (58.06 ± 107.49 pg/ml, 74.26 ± 178.50 pg/ml, 96.86 ± 177.46 pg/ml, 10.64 ± 17.70 pg/ml, respectively). Altogether, our results indicate that IL-17A and IL-17F are produced in vivo in the stomach of AIG patients following activation with H+ /K+ -ATPase and that serum IL-17A, IL-17F, IL-21, and IL-17E levels are significantly elevated in AIG patients but not in patients without AIG. These data suggest a Th17 signature in AIG and that IL-17A, IL-17F, IL-21, and IL-17E may represent a relevant tool for AIG management. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
8. Real-world performance of ATA risk estimates in predicting 1-year DTC outcomes: A prospective multicenter study of 2000 patients (ITCO Study #3)
- Author
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Grani, Giorgio, Zatelli, Maria Chiara, Alfò, Marco, Montesano, Teresa, Torlontano, Massimo, Morelli, Silvia, Deandrea, Maurilio, Antonelli, Alessandro, Francese, Cecilia, Ceresini, Graziano, Orlandi, Fabio, Maniglia, Adele, Bruno, Rocco, Monti, Salvatore, Santaguida, Maria Giulia, Repaci, Andrea, Tallini, Giovanni, Fugazzola, Laura, Monzani, Fabio, Giubbini, Raffaele, Rossetto, Ruth, Mian, Caterina, Crescenzi, Anna, Tumino, Dario, Pagano, Loredana, Pezzullo, Luciano, Lombardi, Celestino Pio, Arvat, Emanuela, Petrone, Luisa, Castagna, Maria Grazia, Spiazzi, Giovanna, Salvatore, Domenico, Meringolo, Domenico, Solaroli, Erica, Monari, Fabio, Magri, Flavia, Triggiani, Vincenzo, Castello, Roberto, Piazza, Cesare, Rossi, Roberta, Ferraro Petrillo, Umberto, Filetti, Sebastiano, and Durante, Cosimo
- Subjects
evidence based guidelines ,differentiated thyroid cancer ,clinical practice ,risk stratification - Published
- 2020
9. Real-World Performance of the American Thyroid Association Risk Estimates in Predicting 1-Year Differentiated Thyroid Cancer Outcomes: A Prospective Multicenter Study of 2000 Patients
- Author
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Grani, Giorgio, Chiara Zatelli, Maria, Alfò, Marco, Montesano, Teresa, Torlontano, Massimo, Morelli, Silvia, Deandrea, Maurilio, Antonelli, Alessandro, Francese, Cecilia, Ceresini, Graziano, Orlandi, Fabio, Adele Maniglia, Carolina, Bruno, Rocco, Monti, Salvatore, Giulia Santaguida, Maria, Repaci, Andrea, Tallini, Giovanni, Fugazzola, Laura, Monzani, Fabio, Giubbini, Raffaele, Rossetto, Ruth, Mian 21, Caterina, Crescenzi 22, Anna, Tumino, Dario, Pagano, Loredana, Pezzullo, Luciano, Lombardi, Celestino Pio, Arvat, Emanuela, Petrone, Luisa, Grazia Castagna, Maria, Spiazzi, Giovanna, Salvatore, Domenico, Meringolo, Domenico, Solaroli, Erica, Monari, Fabio, Magri, Flavia, Triggiani, Vincenzo, Castello, Roberto, Piazza, Cesare, Rossi, Roberta, Ferraro Petrillo, Umberto, Filetti, Sebastiano, Durante, Cosimo, Celestino Pio Lombardi (ORCID:0000-0001-8910-6693), Grani, Giorgio, Chiara Zatelli, Maria, Alfò, Marco, Montesano, Teresa, Torlontano, Massimo, Morelli, Silvia, Deandrea, Maurilio, Antonelli, Alessandro, Francese, Cecilia, Ceresini, Graziano, Orlandi, Fabio, Adele Maniglia, Carolina, Bruno, Rocco, Monti, Salvatore, Giulia Santaguida, Maria, Repaci, Andrea, Tallini, Giovanni, Fugazzola, Laura, Monzani, Fabio, Giubbini, Raffaele, Rossetto, Ruth, Mian 21, Caterina, Crescenzi 22, Anna, Tumino, Dario, Pagano, Loredana, Pezzullo, Luciano, Lombardi, Celestino Pio, Arvat, Emanuela, Petrone, Luisa, Grazia Castagna, Maria, Spiazzi, Giovanna, Salvatore, Domenico, Meringolo, Domenico, Solaroli, Erica, Monari, Fabio, Magri, Flavia, Triggiani, Vincenzo, Castello, Roberto, Piazza, Cesare, Rossi, Roberta, Ferraro Petrillo, Umberto, Filetti, Sebastiano, Durante, Cosimo, and Celestino Pio Lombardi (ORCID:0000-0001-8910-6693)
- Abstract
Background: One of the most widely used risk stratification systems for estimating individual patients' risk of persistent or recurrent differentiated thyroid cancer (DTC) is the American Thyroid Association (ATA) guidelines. The 2015 ATA version, which has increased the number of patients considered at low or intermediate risk, has been validated in several retrospective, single-center studies. The aims of this study were to evaluate the real-world performance of the 2015 ATA risk stratification system in predicting the response to treatment 12 months after the initial treatment and to determine the extent to which this performance is affected by the treatment center in which it is used. Methods: A prospective cohort of DTC patients collected by the Italian Thyroid Cancer Observatory web-based database was analyzed. We reviewed all records present in the database and selected consecutive cases that satisfied inclusion criteria: (i) histological diagnosis of DTC, with the exclusion of noninvasive follicular thyroid neoplasm with papillary-like nuclear features; (ii) complete data of the initial treatment and pathological features; and (iii) results of 1-year follow-up visit (6-18 months after the initial treatment), including all data needed to classify the estimated response to treatment. Results: The final cohort was composed of 2071 patients from 40 centers. The ATA risk of persistent/recurrent disease was classified as low in 1109 patients (53.6%), intermediate in 796 (38.4%), and high in 166 (8.0%). Structural incomplete responses were documented in only 86 (4.2%) patients: 1.5% in the low-risk, 5.7% in the intermediate-risk, and 14.5% in the high-risk group. The baseline ATA risk class proved to be a significant predictor of structural persistent disease, both for intermediate-risk (odds ratio [OR] 4.67; 95% confidence interval [CI] 2.59-8.43) and high-risk groups (OR 16.48; CI 7.87-34.5). Individual center did not significantly influence the prediction of the
- Published
- 2020
10. Intrinsic factor recognition promotes T helper 17/T helper 1 autoimmune gastric inflammation in patients with pernicious anemia
- Author
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Troilo, Arianna, primary, Grassi, Alessia, additional, Petrone, Luisa, additional, Cianchi, Fabio, additional, Benagiano, Marisa, additional, Bella, Chiara Della, additional, Capitani, Nagaja, additional, Bitetti, Jacopo, additional, D’Elios, Sofia, additional, Tapinassi, Simona, additional, Azzurri, Annalisa, additional, Alnwaisri, Heba, additional, Romagnoli, Jacopo, additional, Bizzaro, Nicola, additional, Bergman, Mathijs, additional, Baldari, Cosima Tatiana, additional, and D’Elios, Mario Milco, additional
- Published
- 2019
- Full Text
- View/download PDF
11. Integrity and Quantity of Total Cell-Free DNA in the Diagnosis of Thyroid Cancer: Correlation with Cytological Classification
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Salvianti, Francesca, primary, Giuliani, Corinna, additional, Petrone, Luisa, additional, Mancini, Irene, additional, Vezzosi, Vania, additional, Pupilli, Cinzia, additional, and Pinzani, Pamela, additional
- Published
- 2017
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12. A comparison of NCEP-ATPIII and IDF metabolic syndrome definitions with relation to metabolic syndrome-associated sexual dysfunction
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Corona, Giovanni, Petrone, Luisa, Fisher, Alessandra Daphne, Maggi, Mario, Chiarini, Valerio, Mannucci, Edoardo, Schulman, Claude, Balercia, Giancarlo, Forti, Gianni, Corona, Giovanni, Petrone, Luisa, Fisher, Alessandra Daphne, Maggi, Mario, Chiarini, Valerio, Mannucci, Edoardo, Schulman, Claude, Balercia, Giancarlo, and Forti, Gianni
- Abstract
Introduction: Metabolic syndrome (MetS) is a clustering of cardiovascular and metabolic risk factors, often associated with erectile dysfunction (ED) and hypogonadism. Recently, the International Diabetes Federation (IDF) proposed a substantial revision of the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATPIII) MetS criteria, essentially lowering the diagnostic cutoff values. Aim: To investigate the associations between these two recently proposed definitions of MetS with the relative risk of arteriogenic ED and hypogonadism in a large cohort of patients with male sexual dysfunction. Methods: A consecutive series of 1086 patients with sexual dysfunction (mean age 51.9 ± 12.8 years) was studied. Main Outcome Measures: Several hormonal, biochemical, and instrumental (penile Doppler ultrasound) parameters were studied, along with ANDROTEST, a 12-item validated structured interview, specifically designed for the screening hypogonadism in a sexual dysfunction population. In particular, a score >8 is predictive of low testosterone (<10.4 nmol/L) with a sensitivity and specificity of about 70%. Results: The prevalence of MetS was 32.0% and 44.7% according to NCEP-ATPIII and IDF criteria, respectively. After adjustment for confounding factors, only NCEP-ATPIII was significantly associated with dynamic prostaglandin E1-stimulated penile flow (Vpmax, B = -7.7 ± 3.8; P < 0.05). Patients with MetS defined according to both criteria reported lower total and free testosterone levels, higher prevalence of hypogonadism, and higher ANDROTEST score. However, when IDF, but not NCEP-ATPIII, criteria were fulfilled, the prevalence of hypogonadism was significantly lower than that observed in patients fulfilling both criteria (15.6% vs. 34.8%, respectively; P < 0.00001). Conversely, patients fulfilling NCEP-ATPIII, but not IDF, criteria did not show a significant different prevalence of hypogonadism than those positive for both sets of criteria (30.8% vs. 34., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2007
13. Psychobiologic Correlates of the Metabolic Syndrome and Associated Sexual Dysfunction
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Corona, Giovanni, Petrone, Luisa, Mansani, Riccardo, Cilotti, Antonio, Forti, Gianni, Maggi, Mario, Mannucci, Edoardo, Schulman, Claude, Balercia, Giancarlo, Chiarini, Valerio, Corona, Giovanni, Petrone, Luisa, Mansani, Riccardo, Cilotti, Antonio, Forti, Gianni, Maggi, Mario, Mannucci, Edoardo, Schulman, Claude, Balercia, Giancarlo, and Chiarini, Valerio
- Abstract
Objectives: The association of low testosterone level and erectile dysfunction (ED) with metabolic syndrome (MS) is receiving increasing attention. The present study determined the psychobiologic characteristics of sexual dysfunction (SD) associated with MS (as defined by the National Cholesterol Education Program's Adult Treatment Panel III criteria) in a series of 803 consecutive male outpatients. Methods: Several hormonal, biochemical, and instrumental (penile Doppler ultrasound [PDU]) parameters were studied, along with general psychopathology scores (Middlesex Hospital Questionnaire modified [MHQ]). The Structured Interview on Erectile Dysfunction (SIEDY) was also applied. Results: Among the 236 patients (29.4%) diagnosed as having a MS, 96.5% reported ED, 39.6% hypoactive sexual desire (HSD), 22.7% premature ejaculation, and 4.8% delayed ejaculation. Patients with MS were characterised by greater subjective (as assessed by SIEDY) and objective (as assessed by PDU) ED and by greater somatised anxiety than the rest of the sample. The prevalence of overt hypogonadism (total testosterone <8 nM) was significantly higher in patients with MS. Among MS components, waist circumference and hyperglycaemia were the best predictors of hypogonadism. Hypogonadal patients with MS showed higher gonadotropin and lower free testosterone levels, suggesting a primary hypogonadism. Among patients with MS, hypogonadism was present in 11.9% and 3.8% in the rest of the sample (p < 0.0001) and was associated with typical hypogonadism-related symptoms, such as hypoactive sexual desire, low frequency of sexual intercourse, and depressive symptoms. Conclusions: Our data suggest that MS is associated with a more severe ED and induces somatisation. Furthermore, MS is associated with a higher prevalence of hypogonadism in patients with SD. The presence of hypogonadism can further exacerbate the MS-associated sexual dysfunction, adding the typical hypogonadism-related symptoms (including HSD, SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2006
14. A High-Resolution Melting Protocol for Rapid and Accurate Differential Diagnosis of Thyroid Nodules
- Author
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Mancini, Irene, primary, Pinzani, Pamela, additional, Pupilli, Cinzia, additional, Petrone, Luisa, additional, De Feo, Maria Laura, additional, Bencini, Lapo, additional, Pazzagli, Mario, additional, Forti, Gianni, additional, and Orlando, Claudio, additional
- Published
- 2012
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15. Correlation between, Clinical, Biochemical, Color Doppler Ultrasound Thyroid Parameters, and CXCL-10 in Autoimmune Thyroid Diseases
- Author
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CORONA, Giovanni, primary, BIAGINI, Carlo, additional, ROTONDI, Mario, additional, BONAMANO, Andrea, additional, CREMONINI, Nadia, additional, PETRONE, Luisa, additional, CONFORTI, Barbara, additional, FORTI, Gianni, additional, and SERIO, Mario, additional
- Published
- 2008
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16. Classic and follicular variant of papillary thyroid microcarcinoma: 2 different phenotypes beyond tumor size
- Author
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Sparano, Clotilde, Rotondi, Mario, Verdiani, Valentina, Brunori, Paolo, Castiglione, Francesca, Bartoli, Caterina, Perigli, Giuliano, Badii, Benedetta, Vezzosi, Vania, Simontacchi, Gabriele, Livi, Lorenzo, Antonuzzo, Lorenzo, Maggi, Mario, Petrone, Luisa, Sparano, Clotilde, Rotondi, Mario, Verdiani, Valentina, Brunori, Paolo, Castiglione, Francesca, Bartoli, Caterina, Perigli, Giuliano, Badii, Benedetta, Vezzosi, Vania, Simontacchi, Gabriele, Livi, Lorenzo, Antonuzzo, Lorenzo, Maggi, Mario, and Petrone, Luisa
- Abstract
Context: Despite the wide revision of current guidelines, the management of papillary thyroid microcarcinoma (mPTC) still has to be decided case by case. There is conflicting evidence about the role of more frequent histological subtypes, and no data about potential differences at presentation. Objective: Our aim was to compare the phenotype of the 2 most frequent mPTC variants, namely, classical papillary thyroid microcarcinoma (mPTCc) and the follicular variant of papillary thyroid microcarcinoma (mFVPTC). Methods: Retrospective observational study, from January 2008 to December 2017 of a consecutive series of patients with mPTCc and mFVPTC. All cases were classified according to the 2015 American Thyroid Association (ATA) risk classification. Clinical and preclinical features of mPTCc and mFVPTC at diagnosis were collected. The comparison was also performed according to the incidental/nonincidental diagnosis and differences were verified by binary logistic analysis. Results: In total, 235 patients were eligible for the analysis (125 and 110 mPTCc and mFVPTC, respectively). Compared with mPTCc, mFVPTCs were more often incidental and significantly smaller (4 vs 7mm) (P <. 001 all), possibly influenced by the higher rate of incidental detection. mFVPTC and incidental (P <. 001 both) tumors were significantly more often allocated within the low-risk class. A logistic regression model, with ATA risk class as the dependent variable, showed that both mFVPTC (OR 0.465 [0.235-0.922]; P =. 028]) and incidental diagnosis (OR 0.074 [0.036-0.163]; P <. 001) independently predicted ATA risk stratification. Conclusion: mFVPTC shows some differences in diagnostic presentation compared with mPTCc, and seems to retain a significant number of favorable features, including a prevalent onset as incidental diagnosis.
17. Real-World Performance of the American Thyroid Association Risk Estimates in Predicting 1-Year Differentiated Thyroid Cancer Outcomes: A Prospective Multicenter Study of 2000 Patients
- Author
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Laura Fugazzola, Cecilia Francese, Silvia Morelli, Andrea Repaci, Luisa Petrone, Marco Alfò, Fabio Orlandi, Carolina Adele Maniglia, Emanuela Arvat, Teresa Montesano, Caterina Mian, Giorgio Grani, Maria Chiara Zatelli, R. Rossetto, Maria Grazia Castagna, Massimo Torlontano, Dario Tumino, Fabio Monari, Maria Giulia Santaguida, Erica Solaroli, Domenico Salvatore, Graziano Ceresini, Cesare Piazza, Roberto Castello, Raffaele Giubbini, Loredana Pagano, Domenico Meringolo, Sebastiano Filetti, Salvatore Monti, Giovanna Spiazzi, Vincenzo Triggiani, Flavia Magri, Anna Crescenzi, Giovanni Tallini, Rocco Bruno, Luciano Pezzullo, Cosimo Durante, Celestino Pio Lombardi, Fabio Monzani, Alessandro Antonelli, Maurilio Deandrea, Umberto Ferraro Petrillo, Roberta Elisa Rossi, Grani, Giorgio, Zatelli, Maria Chiara, Alfò, Marco, Montesano, Teresa, Torlontano, Massimo, Morelli, Silvia, Deandrea, Maurilio, Antonelli, Alessandro, Francese, Cecilia, Ceresini, Graziano, Orlandi, Fabio, Maniglia, Carolina Adele, Bruno, Rocco, Monti, Salvatore, Santaguida, Maria Giulia, Repaci, Andrea, Tallini, Giovanni, Fugazzola, Laura, Monzani, Fabio, Giubbini, Raffaele, Rossetto, Ruth, Mian, Caterina, Crescenzi, Anna, Tumino, Dario, Pagano, Loredana, Pezzullo, Luciano, Lombardi, Celestino Pio, Arvat, Emanuela, Petrone, Luisa, Castagna, Maria Grazia, Spiazzi, Giovanna, Salvatore, Domenico, Meringolo, Domenico, Solaroli, Erica, Monari, Fabio, Magri, Flavia, Triggiani, Vincenzo, Castello, Roberto, Piazza, Cesare, Rossi, Roberta, Ferraro Petrillo, Umberto, Filetti, Sebastiano, and Durante, Cosimo
- Subjects
Male ,Time Factors ,Databases, Factual ,Settore MED/18 - CHIRURGIA GENERALE ,Endocrinology, Diabetes and Metabolism ,differentiated thyroid cancer ,evidence-based guidelines ,clinical practice ,risk stratification ,medicine.disease_cause ,Iodine Radioisotopes ,0302 clinical medicine ,Endocrinology ,Risk Factors ,thyroid cancer ,Prospective Studies ,LS4_3 ,Prospective cohort study ,Thyroid cancer ,Thyroid ,Cell Differentiation ,evidence-based guideline ,Middle Aged ,Treatment Outcome ,medicine.anatomical_structure ,Italy ,030220 oncology & carcinogenesis ,Cohort ,Thyroidectomy ,Female ,evidence based guidelines ,Adult ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Risk Assessment ,Decision Support Techniques ,NO ,03 medical and health sciences ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Thyroid Neoplasms ,Pathological ,Thyroid neoplasm ,Settore MED/06 - ONCOLOGIA MEDICA ,business.industry ,Odds ratio ,medicine.disease ,Confidence interval ,Lymph Node Excision ,Neoplasm Recurrence, Local ,Radiopharmaceuticals ,business - Abstract
Background: One of the most widely used risk stratification systems for estimating individual patients' risk of persistent or recurrent differentiated thyroid cancer (DTC) is the American Thyroid Association (ATA) guidelines. The 2015 ATA version, which has increased the number of patients considered at low or intermediate risk, has been validated in several retrospective, single-center studies. The aims of this study were to evaluate the real-world performance of the 2015 ATA risk stratification system in predicting the response to treatment 12 months after the initial treatment and to determine the extent to which this performance is affected by the treatment center in which it is used. Methods: A prospective cohort of DTC patients collected by the Italian Thyroid Cancer Observatory web-based database was analyzed. We reviewed all records present in the database and selected consecutive cases that satisfied inclusion criteria: (i) histological diagnosis of DTC, with the exclusion of noninvasive follicular thyroid neoplasm with papillary-like nuclear features; (ii) complete data of the initial treatment and pathological features; and (iii) results of 1-year follow-up visit (6-18 months after the initial treatment), including all data needed to classify the estimated response to treatment. Results: The final cohort was composed of 2071 patients from 40 centers. The ATA risk of persistent/recurrent disease was classified as low in 1109 patients (53.6%), intermediate in 796 (38.4%), and high in 166 (8.0%). Structural incomplete responses were documented in only 86 (4.2%) patients: 1.5% in the low-risk, 5.7% in the intermediate-risk, and 14.5% in the high-risk group. The baseline ATA risk class proved to be a significant predictor of structural persistent disease, both for intermediate-risk (odds ratio [OR] 4.67; 95% confidence interval [CI] 2.59-8.43) and high-risk groups (OR 16.48; CI 7.87-34.5). Individual center did not significantly influence the prediction of the 1-year disease status. Conclusions: The ATA risk stratification system is a reliable predictor of short-term outcomes in patients with DTC in real-world clinical settings characterized by center heterogeneity in terms of size, location, level of care, local management strategies, and resource availability.
- Published
- 2021
18. Gastric Th17 Cells Specific for H + /K + -ATPase and Serum IL-17 Signature in Gastric Autoimmunity.
- Author
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Della Bella C, Antico A, Panozzo MP, Capitani N, Petrone L, Benagiano M, D'Elios S, Sparano C, Azzurri A, Pratesi S, Cianchi F, Ortiz-Princz D, Bergman M, Bizzaro N, and D'Elios MM
- Subjects
- Adenosine Triphosphatases, Cytokines, Gastric Mucosa, H(+)-K(+)-Exchanging ATPase, Humans, Interleukin-17, Autoimmunity immunology, Gastritis diagnosis, Gastritis immunology, Th17 Cells
- Abstract
Human gastric autoimmunity [autoimmune gastritis (AIG)] is characterized by inflammation of the gastric mucosa and parietal cell loss. The gastric parietal cell proton pump H
+ /K+ -adenosine triphosphatase (H+ /K+ -ATPase) is the major autoantigen in AIG. Our work aimed to investigate the gastric H+ /K+ -ATPase-specific T helper 17 (Th17) responses in AIG and serum interleukin (IL)-17 cytokine subfamily in AIG patients, in healthy subjects [healthy controls (HCs)], and in patients with iron deficiency anemia (IDA) without AIG. We analyzed the activation of gastric lamina propria mononuclear cells (LPMCs) by H+ /K+ -ATPase and the IL-17A and IL-17F cytokine production in eight patients with AIG and four HCs. Furthermore, we compared serum levels of IL-17A, IL-17F, IL-21, IL-17E, IL-22, and IL-23 in 43 AIG patients, in 47 HCs, and in 20 IDA patients without AIG. Gastric LPMCs from all AIG patients, but not those from HCs, were activated by H+ /K+ -ATPase and were able to proliferate and produce high levels of IL-17A and IL-17F. AIG patients have significantly higher serum IL-17A, IL-17F, IL-21, and IL-17E (393.3 ± 410.02 pg/ml, 394.0 ± 378.03 pg/ml, 300.46 ± 303.45 pg/ml, 34.92 ± 32.56 pg/ml, respectively) than those in HCs (222.99 ± 361.24 pg/ml, 217.49 ± 312.1 pg/ml, 147.43 ± 259.17 pg/ml, 8.69 ± 8.98 pg/ml, respectively) and those in IDA patients without AIG (58.06 ± 107.49 pg/ml, 74.26 ± 178.50 pg/ml, 96.86 ± 177.46 pg/ml, 10.64 ± 17.70 pg/ml, respectively). Altogether, our results indicate that IL-17A and IL-17F are produced in vivo in the stomach of AIG patients following activation with H+ /K+ -ATPase and that serum IL-17A, IL-17F, IL-21, and IL-17E levels are significantly elevated in AIG patients but not in patients without AIG. These data suggest a Th17 signature in AIG and that IL-17A, IL-17F, IL-21, and IL-17E may represent a relevant tool for AIG management., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Della Bella, Antico, Panozzo, Capitani, Petrone, Benagiano, D’Elios, Sparano, Azzurri, Pratesi, Cianchi, Ortiz-Princz, Bergman, Bizzaro and D’Elios.)- Published
- 2022
- Full Text
- View/download PDF
19. Assessment of the relational factor in male patients consulting for sexual dysfunction: the concept of couple sexual dysfunction.
- Author
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Corona G, Petrone L, Mannucci E, Magini A, Lotti F, Ricca V, Chiarini V, Forti G, and Maggi M
- Subjects
- Female, Humans, Interview, Psychological, Male, Middle Aged, Sexual Dysfunctions, Psychological physiopathology, Erectile Dysfunction psychology, Interpersonal Relations, Sexual Dysfunctions, Psychological psychology
- Abstract
In a consecutive series of 1140 male subjects reporting a stable couple relationship and different degrees of sexual dysfunction, we evaluated the impact of relational factors, as assessed by the Structured Interview on Erectile Dysfunction (SIEDY) Scale 2 (exploring, as reported by the patient, menopausal symptoms, partner's medical illness interfering with sexual activity, and reduced partner desire and climax). We found that the SIEDY Scale 2 is significantly and independently associated with erectile dysfunction (ED), delayed ejaculation, hypoactive sexual desire, and decreased frequency of intercourse. SIEDY Scale 2 scores are associated with an advanced age of the partner and a long couple relationship, independently from patient's age. In addition, an increased relational factor correlates with increased extramarital affairs, conflicts in the couple, alcohol abuse, and presence of depressive symptoms, as assessed by the Middlesex Hospital Questionnaire. Our results should encourage the andrologist to consider the context in which sexual symptoms develop, analyzing the relationship and partner's behaviors and diseases. Resolving, or at least ameliorating, the relational background and the sexual framework might help in treating male sexual dysfunction.
- Published
- 2006
- Full Text
- View/download PDF
20. Psychobiological correlates of delayed ejaculation in male patients with sexual dysfunctions.
- Author
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Corona G, Mannucci E, Petrone L, Fisher AD, Balercia G, De Scisciolo G, Pizzocaro A, Giommi R, Chiarini V, Forti G, and Maggi M
- Subjects
- Ejaculation drug effects, Humans, Male, Nervous System Diseases complications, Serotonin Agents adverse effects, Selective Serotonin Reuptake Inhibitors adverse effects, Sexual Dysfunction, Physiological etiology, Sexual Dysfunctions, Psychological etiology, Sexual Dysfunctions, Psychological psychology, Ejaculation physiology, Sexual Dysfunction, Physiological psychology
- Abstract
The pathogenesis of delayed ejaculation (DE) is rather unknown, though the contribution of various psychological, marital, hormonal, and neurological factors has been advocated. In this study we systematically investigated the relative relevance of the aforementioned factors in 1,632 men who were seeking medical help for sexual dysfunction. The severity of DE was classified according to Kaplan criteria. Mild and moderate forms of DE (MMDE) recognized different risk factors than the most severe ones (anejaculation or severe DE [ASDE]). ASDE was essentially coupled with the presence of neurological diseases or with the use of serotoninergic drugs. Serotoninergic drugs also significantly increase (by at least 10-fold) the risk for MMDE, which, however, was also coupled with other relational factors (eg, partner's impaired climax, patient's hypoactive sexual desire [HSD]) or intrapsychic factors (eg, stress at work). At multiple regression analysis, some organic pathological conditions (such as psychiatric disorders and hypogonadism) were also associated with MMDE. In particular, hypogonadism retained significance for DE even after adjustment for HSD (adjusted odds ratio = 2.08 [1.11-3.89]; P < .05), suggesting other effects of testosterone deficiency on the ejaculatory reflex besides reduced libido. In conclusion, the present study demonstrates that multiple psychobiological determinants are associated with DE, a still obscure condition that substantially impairs psychosexual equilibrium of the couple.
- Published
- 2006
- Full Text
- View/download PDF
21. Psycho-biological correlates of free-floating anxiety symptoms in male patients with sexual dysfunctions.
- Author
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Corona G, Mannucci E, Petrone L, Ricca V, Balercia G, Giommi R, Forti G, and Maggi M
- Subjects
- Adult, Aged, Humans, Life Change Events, Male, Middle Aged, Stress, Psychological, Surveys and Questionnaires, Anxiety physiopathology, Anxiety psychology, Erectile Dysfunction physiopathology, Erectile Dysfunction psychology
- Abstract
Anxiety has a relevant impact on everyday life, including sexual life, and therefore is considered the final common pathway by which social, psychological, and biological stressors negatively affect sexual functioning. The aim of this study is to define the psycho-biological correlates of free-floating anxiety in a large sample of patients complaining of erectile dysfunction (ED)-based sexual problems. We studied a consecutive series of 882 ED patients using SIEDY, a 13-item structured interview, composed of 3 scales that identify and quantify organic, relational, and intrapsychic domains. MHQ-A scoring from Middlesex Hospital Questionnaire (MHQ) was used as a putative marker of free-floating anxiety symptoms (AS). Metabolic and hormonal parameters, nocturnal penile tumescence (NPT) test, and penile Doppler ultrasound (PDU) examination were also performed. MHQ-A score was significantly higher in patients complaining of difficulties in maintaining erection and in those reporting premature ejaculation (6.5 +/- 3.3 vs 5.8 +/- 3.3 and 6.6 +/- 3.3 vs 6.1 +/- 3.3, respectively; both P < .05). Moreover, ASs were significantly correlated to life stressors quantified by SIEDY scale 2 (relational component) and scale 3 (intrapsychic component) scores, as dissatisfaction at work or within the family or couple relationships. Among physical, biochemical, or instrumental parameters tested, only end-diastolic velocity at PDU was significantly (P < .05) related to ASs. In conclusion, in patients with ED-based sexual problems, ASs are correlated to many relational and life stressors. Conversely, organic problems are not necessarily associated with MHQ-A score.
- Published
- 2006
- Full Text
- View/download PDF
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