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1. Association of body mass index and waist circumference with long-term mortality risk in 10,370 coronary patients and potential modification by lifestyle and health determinants

Author

Cruijsen, Esther, Bonekamp, Nadia E., Koopal, Charlotte, Winkels, Renate M., Visseren, Frank L.J., Geleijnse, J.M., van Damme, I., Heerkens, L., Khandpur, N., Jacobo Cejudo, M.G., Pertiwi, K., van Westing, A.C., Cramer, M.J., Nathoe, H.M., van de Meer, M.G., de Borst, G.J., Teraa, M., Bots, M.L., van Smeden, M., Emmelot-Vonk, M.H., de Jong, P.A., Lely, A.T., van der Kaaij, N.P., Kappelle, L.J., Ruigrok, Y.M., Verhaar, M.C., Dorresteijn, J.A.N., Visseren, F.L.J., Cruijsen, Esther, Bonekamp, Nadia E., Koopal, Charlotte, Winkels, Renate M., Visseren, Frank L.J., Geleijnse, J.M., van Damme, I., Heerkens, L., Khandpur, N., Jacobo Cejudo, M.G., Pertiwi, K., van Westing, A.C., Cramer, M.J., Nathoe, H.M., van de Meer, M.G., de Borst, G.J., Teraa, M., Bots, M.L., van Smeden, M., Emmelot-Vonk, M.H., de Jong, P.A., Lely, A.T., van der Kaaij, N.P., Kappelle, L.J., Ruigrok, Y.M., Verhaar, M.C., Dorresteijn, J.A.N., and Visseren, F.L.J.

Abstract

Background and aims Body adiposity is known to affect mortality risk in patients with coronary artery disease (CAD). We examined associations of body mass index (BMI) and waist circumference (WC) with long term mortality in Dutch CAD patients, and potential and effect modification of these associations by lifestyle and health determinants. Methods 10,370 CAD patients (mean age *65 y; 20% female; >80% on cardiovascular drugs) from the prospective Alpha Omega Cohort and Utrecht Cardiovascular Cohort–Secondary Manifestations of ARTerial disease study were included. Cox models were used to estimate categorical and continuous associations (using restricted cubic splines) of measured BMI and WC with all-cause and cardiovascular mortality risk, adjusting for age, sex, smoking, alcohol, physical activity and educational level. Analyses were repeated in subgroups of lifestyle factors (smoking, physical activity, diet quality), education and health determinants (diabetes, self-rated health). Results During *10 years of follow-up (91,947 person-years), 3,553 deaths occurred, including 1,620 from cardiovascular disease. U-shaped relationships were found for BMI and mortality risk, with the lowest risk for overweight patients (BMI *27 kg/m2). For obesity (BMI ≥30), the HR for all-cause mortality was 1.31 (95% CI: 1.11, 1.41) in male patients and 1.10 (95% CI: 0.92, 1.30) in female patients, compared to BMI 25–30 kg/m2. WC was also non-linearly associated with mortality, and HRs were 1.18 (95%CI:1.06, 1.30) in males and 1.31 (95% CI:1.05, 1.64) in females for the highest vs. middle category of WC. Results for cardiovascular mortality were mostly in line with the results for all-cause mortality. U-shaped associations were found in most subgroups, associations were moderately modified by physical activity, smoking and educational level. Conclusions CAD patients with obesity and a large WC were at increased risk of long-term CVD and all-cause mortality, while mildly overweight patie

Published
2024

4. Hypertension Prevention Education Through Training in Making Herbal Teas in Talango Village, Talango District, Sumenep Regency

Author

Maharani Pertiwi K, Bastiana Bastiana, Asma Rubiah Rosyadahan, Suprapto Maat, Isdiantoni Isdiantoni, and Endry Nugroho Prasetyo

Abstract

Talango Village is one of the villages located in Talango District, Sumenep Regency. The people of this village make a living mainly as fishermen and farmers. One of the habits carried out by fishers and farmers in between their activities is smoking. The nicotine in cigarette smoke can increase blood pressure and heart rate, narrow arteries, harden their walls, and make blood more likely to clot. This condition can increase the risk of hypertension or high blood pressure. Based on interviews and surveys with partners Yayasan Jala Tani Pertiwi, education about hypertension prevention needs to be carried out to prevent hypertension in fishers and hypertension in Talango Village. This problem has prompted a service team to design educational activities to prevent hypertension by manufacturing herbal teas. This activity is structured through the first step, namely the preparation stage (compilation of training modules, participant selection, and evaluation media creation), the second stage (the process of implementing activities with pre-/post-test and discussion), and the third stage (evaluating the results of the training). A total of 20 farmers and fishers who are members of the Jala Tani Pertiwi Foundation were given education about hypertension, then continued with training to make anti-hypertensive herbal teas. The evaluation results showed an increase in participants' understanding of the material provided by 34%. Participants are known to have been able to understand and make herbal teas made from Moringa leaves, jasmine flowers, lemongrass leaves, and roselle flowers. Furthermore, to increase the participants' interest in this activity, the service team also taught them how to make tea packaging and how to sell it.

Published
2022

5. TEKNIK DIAGNOSTIK KONVENSIAL DAN LANJUTAN UNTUK INFEKSI BAKTERI DAN RESISTENSI ANTIBAKTERI DI INDONESIA

Author

Feby Arlingga Putri, Evi Fibriani, Ucik Ghorizatul Urjiyah, Habiba Anggraeny Rodja, Khairunnisa Kusuma Wulandari, and Maharani Pertiwi K

Abstract

Infeksi bakteri patogen menjadi salah satu permasalahan kesehatan di Indonesia. Kondisi ini diperparah dengan munculnya strain bakteri yang resistan terhadap antibiotik. Upaya penegakan diagnosa infeksi bakteri terutama yang resisten antibiotik menjadi salah satu strategi pengendaliannya. Teknik diagnostik mikrobiologi yang cepat, mudah dan harga terjangkau diperlukan untuk mendeteksi keberadaan bakteri patogen, membedakan antara infeksi virus atau bakteri, mengidentifikasi resistensi antibiotik pada bakteri, dan untuk mengetahui agen anti mikroba mana yang harus digunakan dalam terapi. Pada umumnya, pemeriksaan mikrobiologi pada laboratorium medis dilakukan melalui teknik konvensional, yaitu kultur bakteri dalam media buatan, isolasi dan purifikasi isolat, pengamatan makroskopis, uji biokimia dan uji kepekaan antibiotik. Teknik diagnostik lanjutan pemeriksaan infeksi bakteri, yaitu secara molekuler melalui metode amplifikasi gen (Polymerase Chain Reaction, PCR). Metode ini dapat memberikan identifikasi patogen dan dapat mendeteksi keberadaan gen resistensi atau protein resistensi. Kombinasi teknik konvensional dan molekuler adalah pilihan terbaik untuk penegakan diagnosa infeksi bakteri dan identifikasi strain resistan antibakteri, serta penentuan tindakan pengendalian dan pencegahan yang tepat terhadap infeksi. Kajian pustaka ini menyajikan teknik diagnostik yang dapat diaplikasikan di laboratorium medis untuk mengidentifikasi infeksi bakteri, sehingga memberikan wacana dan mendorong pengembangan teknik pemeriksaan mikrobiologi yang lebih efektif dan efisien.

Published
2021

7. N-3 fatty acid biomarkers and incident type 2 diabetes: An individual participant-level pooling project of 20 prospective cohort studies.

Author

Qian F., Ardisson Korat A.V., Imamura F., Marklund M., Tintle N., Virtanen J.K., Zhou X., Bassett J.K., Lai H., Hirakawa Y., Chien K.-L., Wood A.C., Lankinen M., Murphy R.A., Samieri C., Pertiwi K., de Mello V.D., Guan W., Forouhi N.G., Wareham N., Consortium I., Hu F.B., Riserus U., Lind L., Harris W.S., Shadyab A.H., Robinson J.G., Steffen L.M., Hodge A., Giles G.G., Ninomiya T., Uusitupa M., Tuomilehto J., Lindstrom J., Laakso M., Siscovick D.S., Helmer C., Geleijnse J.M., Wu J.H.Y., Fretts A., Lemaitre R.N., Micha R., Mozaffarian D., Sun Q., Qian F., Ardisson Korat A.V., Imamura F., Marklund M., Tintle N., Virtanen J.K., Zhou X., Bassett J.K., Lai H., Hirakawa Y., Chien K.-L., Wood A.C., Lankinen M., Murphy R.A., Samieri C., Pertiwi K., de Mello V.D., Guan W., Forouhi N.G., Wareham N., Consortium I., Hu F.B., Riserus U., Lind L., Harris W.S., Shadyab A.H., Robinson J.G., Steffen L.M., Hodge A., Giles G.G., Ninomiya T., Uusitupa M., Tuomilehto J., Lindstrom J., Laakso M., Siscovick D.S., Helmer C., Geleijnse J.M., Wu J.H.Y., Fretts A., Lemaitre R.N., Micha R., Mozaffarian D., and Sun Q.

Abstract

OBJECTIVE Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of a-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULTS A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS Highercirculating biomarkers of seafood-derivedn-3 fattyacids, including EPA,DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.Copyright © 2021 by the American Diabetes Association.

Published
2021

8. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies.

Author

Fretts A., Sun Q., Qian F., Ardisson Korat A.V., Imamura F., Marklund M., Tintle N., Mozaffarian D., Virtanen J.K., Zhou X., Bassett J.K., Lai H., Hirakawa Y., Chien K.-L., Wood A.C., Lankinen M., Murphy R.A., Samieri C., Micha R., Lemaitre R.N., Pertiwi K., de Mello V.D., Guan W., Forouhi N.G., Wareham N., Hu I.C.F.B., Riserus U., Lind L., Harris W.S., Shadyab A.H., Robinson J.G., Steffen L.M., Hodge A., Giles G.G., Ninomiya T., Uusitupa M., Tuomilehto J., Lindstrom J., Laakso M., Siscovick D.S., Helmer C., Geleijnse J.M., Wu J.H.Y., Fretts A., Sun Q., Qian F., Ardisson Korat A.V., Imamura F., Marklund M., Tintle N., Mozaffarian D., Virtanen J.K., Zhou X., Bassett J.K., Lai H., Hirakawa Y., Chien K.-L., Wood A.C., Lankinen M., Murphy R.A., Samieri C., Micha R., Lemaitre R.N., Pertiwi K., de Mello V.D., Guan W., Forouhi N.G., Wareham N., Hu I.C.F.B., Riserus U., Lind L., Harris W.S., Shadyab A.H., Robinson J.G., Steffen L.M., Hodge A., Giles G.G., Ninomiya T., Uusitupa M., Tuomilehto J., Lindstrom J., Laakso M., Siscovick D.S., Helmer C., Geleijnse J.M., and Wu J.H.Y.

Abstract

OBJECTIVE: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULT(S): A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSION(S): Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.Copyright © 2021 by the American Diabetes Association.

Published
2021

9. 'Democracy is the Cure?': Evolving Constructions of Corruption in Indonesia 1994-2014

Author

Pertiwi, K, Ainsworth, S, Pertiwi, K, and Ainsworth, S

Abstract

Corruption is of central interest to business ethics but its meaning is often assumed to be self-evident and universal. In this paper we seek to re-politicize and unsettle the dominant meaning of corruption by showing how it is culturally specific, relationally derived and varies over time. In particular, we show how corruption’s meaning changes depending on its relationship with Western-style liberal democracy and non-Western local experience with its implementation. We chose this focus because promoting democracy is a central plank of the international anti-corruption and development agenda and yet the relationship between corruption and democracy is rarely specified. Adopting a critical-discursive approach that draws on poststructuralism and postcolonialism, we explore how the meaning of corruption constructed in The Jakarta Post (TJP) changed in relation to Indonesia’s experience in implementing democratic reform, a condition of the international financial aid it received following the 1997 Asian Financial Crisis. In the 1990s, corruption was seen as an illness, and democracy the cure; from 2000 to 2011 experience with democracy brought disillusion—democracy had not cured corruption but caused it to spread; while from 2012 to 2014 democracy was constructed as a valued end in its own right, but needed protection from corruption in order to survive. From translating the international development agenda in a relatively straightforward way, TJP moved towards constructions of increasing complexity and ambivalence. This demonstrates how corruption’s meaning is fundamentally contingent and unstable—even dominant meanings have the potential to be contested, showing how they are an effect of power and raising the possibility of alternatives.

Published
2021

10. Circulating n-3 fatty acids and linoleic acid as indicators of dietary fatty acid intake in post-myocardial infarction patients

Author

Pertiwi, K., Kok, D.E., Wanders, A.J., de Goede, J., Zock, P.L., Geleijnse, J.M., Pertiwi, K., Kok, D.E., Wanders, A.J., de Goede, J., Zock, P.L., and Geleijnse, J.M.

Abstract

Background and aims: Population-based studies often use plasma fatty acids (FAs) as objective indicators of FA intake, especially for n-3 FA and linoleic acid (LA). The relation between dietary and circulating FA in cardiometabolic patients is largely unknown. We examined whether dietary n-3 FA and LA were reflected in plasma lipid pools in post-myocardial infarction (MI) patients. Methods and results: Patients in Alpha Omega Cohort filled out a 203-item food-frequency questionnaire from which eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and LA intake were calculated. Circulating individual FA (% total FA) were assessed in cholesteryl esters (CE; n = 4066), phospholipids (PL; n = 838), and additionally in total plasma for DHA and LA (n = 739). Spearman correlation coefficients (rs) were calculated for dietary vs. circulating FA. Circulating FA were also compared across dietary FA quintiles, overall and in subgroups by sex, obesity, diabetes, statin use, and high alcohol intake. Patients were on average 69 years old and 79% was male. Moderate correlations between dietary and circulating levels were observed for EPA (rs ∼0.4 in CE and PL) and DHA (rs ∼0.5 in CE and PL, ∼0.4 in total plasma), but not for ALA (rs ∼0.0). Weak correlations were observed for LA (rs 0.1 to 0.2). Plasma LA was significantly lower in statin users and in patients with a high alcohol intake. Conclusions: In post-MI patients, dietary EPA and DHA were well reflected in circulating levels. This was not the case for LA, which may partly be influenced by alcohol use and statins.

Published
2019

11. PROFIL PENGETAHUAN DAN KEYAKINAN VAKSINASI HPV SEBAGAI UPAYA PENCEGAHAN KANKER SERVIKS PADA MAHASISWI DI UNIVERSITAS AIRLANGGA, SURABAYA

Author

Nabilah Lutfi, Binati Binati, Pertiwi K. Yekti, Dirani Dirani, Hudiya Syadida, Nur S. Hidayatullah, Lia A. Mulya, Gesnita Nugraheni, Ajeng D. Sari, Intan A. Cahyasari, Nurul Cholifah, Akbar T. Firman, and Tiara P. Asriningrum

Subjects
Keyakinan, Pengetahuan, Kanker Serviks, Vaksinasi HPV, Health Belief Model
Abstract

Kanker serviks merupakan pembunuh wanita nomor satu di Indonesia dengan angka kejadian 50% dari 15.000 kasus penderita meninggal dunia. Penyebab utama dari kanker serviks ini adalah HPV (Human Papilloma Virus) serta beberapa faktor resiko lain. Pencegahan primer kanker serviks dapat dilakukan dengan vaksinasi HPV. Pengetahuan tentang kanker serviks masih rendah sehingga hal ini mempengaruhi keyakinan remaja putri dalam melakukan vaksinasi HPV. Penelitian ini bertujuan untuk menganalisis profil pengetahuan dan keyakinan vaksinasi HPV pada mahasiswi di Universitas Airlangga Surabaya dengan menggunakan teori Health Belief Model (HBM). Metode pengambilan sampel yang digunakan adalah kuota non random sampling sehingga digunakan sejumlah 120 sampel yang berstatus mahasiswi dari fakultas kesehatan dan non kesehatan di Universitas Airlangga Surabaya. Sebanyak 70,8% mahasiswi dikategorikan menjadi kelompok dengan nilai pengetahuan yang tinggi, namun pengetahuan tidak signifikan mempengaruhi niat untuk melakukan vaksinasi HPV. Pada teori HBM, keyakinan responden untuk melakukan vaksinasi HPV sebanyak 90,8% memiliki persepsi yang tinggi terhadap persepsi keseriusan dan 92,5% terhadap persepsi manfaat yang didapatkan setelah melakukan vaksinasi HPV. Adanya dukungan keluarga menunjukkan hubungan yang signifikan mempengaruhi niat untuk melakukan vaksinasi HPV (p

Published
2020

12. P3717More fresh thrombi in cardio embolic than vascular related acute vessel syndromes

Author

Meuwissen, M, primary, Remmers, M J M, additional, Pertiwi, K R, additional, Scholzel, B E, additional, Versteylen, R J, additional, De Boer, O, additional, Sturm, M F A M, additional, Van Den Hoef, T P, additional, Ijsselmuiden, A J J, additional, Van Norden, A G W, additional, De Jong, T E A M, additional, Haans, H A W, additional, Aarts, R A H M, additional, Vos, L D, additional, and Van Der Wal, A C, additional

Published
2019
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14. Atherothrombosis and Thromboembolism : Position Paper from the Second Maastricht Consensus Conference on Thrombosis

Author

Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., Asquith, N., Heemskerk, J., Heinzmann, A., Moorlag, M., Mackman, N., van der Meijden, P., Meijers, J. C. M., Heestermans, M., Renne, T., Dolleman, S., Chayoua, W., Ariens, R. A. S., Baaten, C. C., Nagy, M., Kuliopulos, A., Posma, J. J., Harrison, P., Vries, M. J., Crijns, H. J. G. M., Dudink, E. A. M. P., Buller, H. R., Henskens, Y. M. C., Själander, Anders, Zwaveling, S., Erkuner, O., Eikelboom, J. W., Gulpen, A., Peeters, F. E. C. M., Douxfils, J., Olie, R. H., Baglin, T., Leader, A., Schotten, U., Scaf, B., van Beusekom, H. M. M., Mosnier, L. O., van der Vorm, L., Declerck, P., Visser, M., Dippel, D. W. J., Strijbis, V. J., Pertiwi, K., ten Cate-Hoek, A. J., ten Cate, H., Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., Asquith, N., Heemskerk, J., Heinzmann, A., Moorlag, M., Mackman, N., van der Meijden, P., Meijers, J. C. M., Heestermans, M., Renne, T., Dolleman, S., Chayoua, W., Ariens, R. A. S., Baaten, C. C., Nagy, M., Kuliopulos, A., Posma, J. J., Harrison, P., Vries, M. J., Crijns, H. J. G. M., Dudink, E. A. M. P., Buller, H. R., Henskens, Y. M. C., Själander, Anders, Zwaveling, S., Erkuner, O., Eikelboom, J. W., Gulpen, A., Peeters, F. E. C. M., Douxfils, J., Olie, R. H., Baglin, T., Leader, A., Schotten, U., Scaf, B., van Beusekom, H. M. M., Mosnier, L. O., van der Vorm, L., Declerck, P., Visser, M., Dippel, D. W. J., Strijbis, V. J., Pertiwi, K., ten Cate-Hoek, A. J., and ten Cate, H.

Abstract

Atherothrombosis is a leading cause of cardiovascular mortality and long-term morbidity. Platelets and coagulation proteases, interacting with circulating cells and in different vascular beds, modify several complex pathologies including atherosclerosis. In the second Maastricht Consensus Conference on Thrombosis, this theme was addressed by diverse scientists from bench to bedside. All presentations were discussed with audience members and the results of these discussions were incorporated in the final document that presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following five topics: 1. Risk factors, biomarkers and plaque instability: In atherothrombosis research, more focus on the contribution of specific risk factors like ectopic fat needs to be considered; definitions of atherothrombosis are important distinguishing different phases of disease, including plaque (in) stability; proteomic and metabolomics data are to be added to genetic information. 2. Circulating cells including platelets and atherothrombosis: Mechanisms of leukocyte and macrophage plasticity, migration, and transformation in murine atherosclerosis need to be considered; diseasemechanism-based biomarkers need to be identified; experimental systems are needed that incorporatewhole-blood flow to understand how red blood cells influence thrombus formation and stability; knowledge on platelet heterogeneity and priming conditions needs to be translated toward the in vivo situation. 3. Coagulation proteases, fibrin(ogen) and thrombus formation: The role of factor (F) XI in thrombosis including the lower margins of this factor related to safe and effective antithrombotic therapy needs to be established; FXI is a key regulator in linking platelets, thrombin generation, and inflammatory mechanisms in a renin-angiotensin dependent manner; however, the impact on thrombin-dependent PAR signaling needs further study; the fundamental mechanisms in FXIII b

Published
2018
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15. Relationship of potato consumption, total and by preparation method with blood pressure and body mass index: The International Population Study on Macronutrients and Blood Pressure (INTERMAP) US study

Author

Pertiwi, K, Oude Griep, LM, Stamler, J, Chan, Q, Geleijnse, JM, Steffen, LM, Rodriguez, B, Daviglus, ML, Van Horn, L, Elliott, P, University Of Northwestern, and National Institutes of Health

Subjects
Cardiovascular System & Hematology, 1117 Public Health And Health Services, fungi, food and beverages, 1103 Clinical Sciences, 1102 Cardiovascular Medicine And Haematology
Abstract

Background: Limited evidence from prospective US cohort studies suggests that higher potato intake is associated with a higher risk of hypertension and obesity. Different preparation methods affect the nutritional composition of potatoes and are related to different dietary choices that may influence associations with blood pressure and body mass index (BMI). Objective: To investigate potato consumption, total and by preparation method, in relation to blood pressure and BMI. Methods: We used cross-sectional data of 2,195 participants aged 40 to 59 in 1996-1997 from the United States samples of the population-based INTERMAP study. During four visits, four in-depth multipass 24-hour dietary recalls and eight blood pressure measurements were collected. Reported potato intakes were categorized as fried and non-fried potatoes, using the USDA food grouping system. Potato intakes (g/1000 kcal) were averaged over four days. Regression coefficients per 2SD higher intake were estimated using multivariate linear regression analyses with adjustments for age, sex, sample, lifestyle and disease factors, and other food groups. To assess influence on the association, diet quality (by Dietary Approaches to Stop Hypertension adherence score), BMI, urinary sodium and potassium were added separately to the previous model. Results: Median intake of total, non-fried, and fried potatoes were 40 g/d, 23 g/d and 8 g/d, respectively. Total and non-fried potato intakes were not associated with blood pressure. The association between fried potatoes and blood pressure varied by sex (P for interaction=0.03). In women, higher fried potato intake (2SD: 20 g/1000 kcal) was associated with a +3.00 mmHg (95%CI: 1.29, 4.71) higher systolic and +1.26 mmHg (95%CI: 0.15, 2.38) higher diastolic blood pressure, which prevailed after additional, but separate, adjustments for BMI, diet quality, urinary sodium and potassium. Potato chips contributed predominantly (79%) to fried potato intake and accounted for the direct association of fried potatoes and blood pressure (+3.77 mmHg systolic (95%CI: 1.92, 5.62), and +1.80 mmHg diastolic (95%CI: 0.62, 2.98)). The association between fried potatoes and blood pressure was not found in men. In the total population, higher fried potato intake was positively associated with BMI (+0.62, 95%CI: 0.14, 1.09) but attenuated after adjustment for diet quality. Total and non-fried potatoes were not associated with BMI. Conclusions: In contrast to non-fried potato intake, fried potato consumption was directly related to blood pressure in women. This finding is in line with results of previous US cohort studies and suggests that the association of potatoes with blood pressure may depend on preparation method.

Published
2017

17. Reflecting on Indonesia's young academy movement.

Author

Rakhmani I, Yusuf AA, Saleh H, Sakhiyya Z, Pertiwi K, Nasir S, Wiratraman HP, Juliandi B, Nugroho Y, and Jompa J

Subjects
Indonesia, Germany, Netherlands, Islam
Abstract

In the past three decades, there has been a rise in young academy movements in the Global North and South. Such movements, in at least Germany and the Netherlands, have been shown to be quite effective in connecting scientific work with society. Likewise, these movements share a common goal of developing interdisciplinary collaboration among young scientists, which contributes to the growth of a nation's-but also global-scientific endeavors. This paper focuses on the young academy movement in the fourth-largest country hosting the biggest Muslim population in the world, which is also the third-most populous democracy: Indonesia. We observe that there has been rising awareness among the young generation of scientists in Indonesia of the need to advocate for the use of sciences in responding to upcoming and current multidimensional crises. Science advocacy can be seen in their peer-based identification of Indonesia's future challenges, encompassing the fundamental areas for scientific inquiry, discovery, and intervention. We focus on the Indonesian Young Academy of Sciences (ALMI) and its network of young scientists. We describe ALMI's science communication practice, specifically SAINS45 and Science for Indonesia's Biodiversity, and how they have been useful for policymakers, media, and school engagements. The article closes with a reflection on future directions for the young academy movement in Indonesia and beyond., Competing Interests: Competing interests statement:The authors declare no competing interest.

Published
2024
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18. Dietary and Circulating Long-Chain Omega-3 Polyunsaturated Fatty Acids and Mortality Risk After Myocardial Infarction: A Long-Term Follow-Up of the Alpha Omega Cohort.

Author

Pertiwi K, Küpers LK, de Goede J, Zock PL, Kromhout D, and Geleijnse JM

Subjects
Aged, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Netherlands epidemiology, Risk Assessment, Dietary Fats adverse effects, Fatty Acids, Omega-3 adverse effects, Fatty Acids, Omega-3 blood, Myocardial Infarction mortality
Abstract

Background Habitual intake of long-chain omega-3 fatty acids, especially eicosapentaenoic and docosahexaenoic acid (EPA+DHA) from fish, has been associated with a lower risk of fatal coronary heart disease (CHD) in population-based studies. Whether that is also the case for patients with CHD is not yet clear. We studied the associations of dietary and circulating EPA+DHA and alpha-linolenic acid, a plant-derived omega-3 fatty acids, with long-term mortality risk after myocardial infarction. Methods and Results We analyzed data from 4067 Dutch patients with prior myocardial infarction aged 60 to 80 years (79% men, 86% on statins) enrolled in the Alpha Omega Cohort from 2002 to 2006 (baseline) and followed through 2018. Baseline intake of fish and omega-3 fatty acids were assessed through a validated 203-item food frequency questionnaire and circulating omega-3 fatty acids were assessed in plasma cholesteryl esters. Hazard ratios (HRs) with 95% CIs were obtained from Cox regression analyses. During a median follow-up period of 12 years, 1877 deaths occurred, of which 515 were from CHD and 834 from cardiovascular diseases. Dietary intake of EPA+DHA was significantly inversely associated with only CHD mortality (HR, 0.69 [0.52-0.90] for >200 versus ≤50 mg/d; HR, 0.92 [0.86-0.98] per 100 mg/d). Similar results were obtained for fish consumption (HR CHD , 0.74 [0.53-1.03] for >40 versus ≤5 g/d; P trend : 0.031). Circulating EPA+DHA was inversely associated with CHD mortality (HR, 0.71 [0.53-0.94] for >2.52% versus ≤1.29%; 0.85 [0.77-0.95] per 1-SD) and also with cardiovascular diseases and all-cause mortality. Dietary and circulating alpha-linolenic acid were not significantly associated with mortality end points. Conclusions In a cohort of Dutch patients with prior myocardial infarction, higher dietary and circulating EPA+DHA and fish intake were consistently associated with a lower CHD mortality risk. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT03192410.

Published
2021
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19. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies.

Author

Qian F, Ardisson Korat AV, Imamura F, Marklund M, Tintle N, Virtanen JK, Zhou X, Bassett JK, Lai H, Hirakawa Y, Chien KL, Wood AC, Lankinen M, Murphy RA, Samieri C, Pertiwi K, de Mello VD, Guan W, Forouhi NG, Wareham N, Hu ICFB, Riserus U, Lind L, Harris WS, Shadyab AH, Robinson JG, Steffen LM, Hodge A, Giles GG, Ninomiya T, Uusitupa M, Tuomilehto J, Lindström J, Laakso M, Siscovick DS, Helmer C, Geleijnse JM, Wu JHY, Fretts A, Lemaitre RN, Micha R, Mozaffarian D, and Sun Q

Subjects
Biomarkers, Cohort Studies, Docosahexaenoic Acids, Eicosapentaenoic Acid, Humans, Prospective Studies, Diabetes Mellitus, Type 2 epidemiology, Fatty Acids, Omega-3
Abstract

Objective: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis., Research Design and Methods: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis., Results: A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses., Conclusions: Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk., (© 2021 by the American Diabetes Association.)

Published
2021
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20. Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults.

Author

Pertiwi K, Küpers LK, Geleijnse JM, Zock PL, Wanders AJ, Kruger HS, van Zyl T, Kruger IM, and Smuts CM

Subjects
Adult, Aged, Black People genetics, Female, Glucose genetics, Glycated Hemoglobin metabolism, Humans, Linoleic Acid administration & dosage, Liver drug effects, Liver Diseases blood, Liver Diseases diet therapy, Liver Diseases epidemiology, Liver Diseases pathology, Male, Middle Aged, Phospholipids blood, South Africa epidemiology, gamma-Glutamyltransferase blood, Biomarkers blood, Glucose metabolism, Linoleic Acid blood, Liver metabolism
Abstract

Background: The relation between dietary and circulating linoleic acid (18:2 n-6, LA), glucose metabolism and liver function is not yet clear. Associations of dietary and circulating LA with glucose metabolism and liver function markers were investigated., Methods: Cross-sectional analyses in 633 black South Africans (aged > 30 years, 62% female, 51% urban) without type 2 diabetes at baseline of the Prospective Urban Rural Epidemiology study. A cultural-sensitive 145-item food-frequency questionnaire was used to collect dietary data, including LA (percentage of energy; en%). Blood samples were collected to measure circulating LA (% total fatty acids (FA); plasma phospholipids), plasma glucose, glycosylated hemoglobin (HbA1c), serum gamma-glutamyl transferase (GGT), alanine (ALT) and aspartate aminotransferase (AST). Associations per 1 standard deviation (SD) and in tertiles were analyzed using multivariable regression., Results: Mean (±SD) dietary and circulating LA was 6.8 (±3.1) en% and 16.0 (±3.5) % total FA, respectively. Dietary and circulating LA were not associated with plasma glucose or HbA1c (β per 1 SD: - 0.005 to 0.010, P > 0.20). Higher dietary LA was generally associated with lower serum liver enzymes levels. One SD higher circulating LA was associated with 22% lower serum GGT (β (95% confidence interval): - 0.25 (- 0.31, - 0.18), P < 0.001), but only ≤9% lower for ALT and AST. Circulating LA and serum GGT associations differed by alcohol use and locality., Conclusion: Dietary and circulating LA were inversely associated with markers of impaired liver function, but not with glucose metabolism. Alcohol use may play a role in the association between LA and liver function., Trial Registration: PURE North-West Province South Africa study described in this manuscript is part of the PURE study. The PURE study is registered in ClinicalTrials.gov (Identifier: NCT03225586; URL).

Published
2020
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21. Plasma and Dietary Linoleic Acid and 3-Year Risk of Type 2 Diabetes After Myocardial Infarction: A Prospective Analysis in the Alpha Omega Cohort.

Author

Pertiwi K, Wanders AJ, Harbers MC, Küpers LK, Soedamah-Muthu SS, de Goede J, Zock PL, and Geleijnse JM

Subjects
Aged, Aged, 80 and over, Biomarkers blood, Cohort Studies, Diabetes Mellitus, Type 2 blood, Diet, Dietary Fats blood, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction epidemiology, Nutrition Surveys, Prospective Studies, Risk Factors, Trans Fatty Acids administration & dosage, Trans Fatty Acids blood, Diabetes Mellitus, Type 2 etiology, Dietary Fats administration & dosage, Linoleic Acid administration & dosage, Linoleic Acid blood, Myocardial Infarction blood, Myocardial Infarction complications
Abstract

Objective: To study plasma and dietary linoleic acid (LA) in relation to type 2 diabetes risk in post-myocardial infarction (MI) patients., Research Design and Methods: We included 3,257 patients aged 60-80 years (80% male) with a median time since MI of 3.5 years from the Alpha Omega Cohort and who were initially free of type 2 diabetes. At baseline (2002-2006), plasma LA was measured in cholesteryl esters, and dietary LA was estimated with a 203-item food-frequency questionnaire. Incident type 2 diabetes was ascertained through self-reported physician diagnosis and medication use. Hazard ratios (with 95% CIs) were calculated by Cox regressions, in which dietary LA isocalorically replaced the sum of saturated (SFA) and trans fatty acids (TFA)., Results: Mean ± SD circulating and dietary LA was 50.1 ± 4.9% and 5.9 ± 2.1% energy, respectively. Plasma and dietary LA were weakly correlated (Spearman r = 0.13, P < 0.001). During a median follow-up of 41 months, 171 patients developed type 2 diabetes. Plasma LA was inversely associated with type 2 diabetes risk (quintile [Q]5 vs. Q1: 0.44 [0.26, 0.75]; per 5%: 0.73 [0.62, 0.86]). Substitution of dietary LA for SFA+TFA showed no association with type 2 diabetes risk (Q5 vs. Q1: 0.78 [0.36, 1.72]; per 5% energy: 1.18 [0.59, 2.35]). Adjustment for markers of de novo lipogenesis attenuated plasma LA associations., Conclusions: In our cohort of post-MI patients, plasma LA was inversely related to type 2 diabetes risk, whereas dietary LA was not related. Further research is needed to assess whether plasma LA indicates metabolic state rather than dietary LA in these patients., (© 2019 by the American Diabetes Association.)

Published
2020
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22. Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients.

Author

Pertiwi K, Küpers LK, Wanders AJ, de Goede J, Zock PL, and Geleijnse JM

Abstract

Background: Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. In cohort studies, higher circulating 15:0 and 17:0 were associated with lower type 2 diabetes risk. A recent randomized controlled trial in humans suggested that fiber intake also increased circulating 15:0 and 17:0, potentially resulting from fermentation by gut microbes. We examined the associations of dairy and fiber intake with circulating 15:0 and 17:0 in patients with a history of myocardial infarction (MI)., Methods: We performed cross-sectional analyses in a subsample of 869 Dutch post-MI patients of the Alpha Omega Cohort who had data on dietary intake and circulating fatty acids. Dietary intakes (g/d) were assessed using a 203-item food frequency questionnaire. Circulating 15:0 and 17:0 (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesteryl esters (CE). Spearman correlations ( r s ) were computed between intakes of total dairy, dairy fat, fiber, and circulating 15:0 and 17:0., Results: Patients were on average 69 years old, 78% was male and 21% had diabetes. Total dairy intake comprised predominantly milk and yogurt (69%). Dairy fat was mainly derived from cheese (47%) and milk (15%), and fiber was mainly from grains (43%). Circulating 15:0 in PL was significantly correlated with total dairy and dairy fat intake (both r s  = 0.19, p  < 0.001), but not with dietary fiber intake ( r s  = 0.05, p  = 0.11). Circulating 17:0 in PL was correlated both with dairy intake ( r s  = 0.14 for total dairy and 0.11 for dairy fat, p  < 0.001), and fiber intake ( r s  = 0.19, p  < 0.001). Results in CE were roughly similar, except for a weaker correlation of CE 17:0 with fiber ( r s  = 0.11, p  = 0.001). Circulating 15:0 was highest in those with high dairy intake irrespective of fiber intake, while circulating 17:0 was highest in those with high dairy and fiber intake., Conclusions: In our cohort of post-MI patients, circulating 15:0 was associated with dairy intake but not fiber intake, whereas circulating 17:0 was associated with both dairy and fiber intake. These data suggest that cardiometabolic health benefits previously attributed to 17:0 as a biomarker of dairy intake may partly be explained by fiber intake., Competing Interests: Competing interestsAJW and PLZ are employed at Unilever R&D, The Netherlands; JMG received financial support from Unilever for epidemiological studies of dietary and circulating fatty acids; KP, LKK, JdG, no competing interest., (© The Author(s). 2019.)

Published
2019
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