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3. Wheat chromatin architecture is organized in genome territories and transcription factories

Author

Concia, Lorenzo, Veluchamy, Alaguraj, Ramirez-Prado, Juan S., Martin-Ramirez, Azahara, Huang, Ying, Perez, Magali, Domenichini, Severine, Rodriguez Granados, Natalia Y., Kim, Soonkap, Blein, Thomas, Duncan, Susan, Pichot, Clement, Manza-Mianza, Deborah, Juery, Caroline, Paux, Etienne, Moore, Graham, Hirt, Heribert, Bergounioux, Catherine, Crespi, Martin, Mahfouz, Magdy M., Bendahmane, Abdelhafid, Liu, Chang, Hall, Anthony, Raynaud, Cécile, Latrasse, David, and Benhamed, Moussa

Published
2020
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6. El Control Preventivo Empresarial para Mitigar el Riesgo del Lavado de Activos de Sujetos Activos en el Sector de Extracción y Comercialización de la Madera de la Provincia de Coronel Portillo del Departamento de Ucayali - 2017

Author

Palacios Perez, Magali and Lozano Ruiz, Roger

Subjects
Lavado de activos, Control Preventivo, purl.org/pe-repo/ocde/ford#5.06.02 [https], Gestión tributaria y articulación institucional y empresarial, Riesgo
Abstract

magalipalaciosperez@outlook.es El control preventivo empresarial resulta sumamente importante a fin de lograr de que las empresas en el sector de extracción y comercialización de la madera de la provincia de Coronel portillo, pueda detectar anomalías que pueden de manera involuntaria a configurar hechos ilícitos en las operaciones comerciales, que pueden estar asociadas al blanqueo del dinero provenientes del narcotráfico u otros hechos ilegales, permitiendo de esta manera mitigar el riesgo del lavado de activos. El control preventivo de operaciones en efectivo, comercial ayuda evitar a una vinculación sospechosa, o el levantamiento del secreto bancario por desconocimiento del grado de cumplimiento del contador público, la investigación es descriptiva correlacional de diseño transversal no experimental. De acuerdo a los resultados el control preventivo si evita a mitigar el riesgo del lavado de activos en el sector extracción y comercialización de manera en la provincia de Coronel Portillo.

Published
2021

7. GCN5 modulates salicylic acid homeostasis by regulating H3K14ac levels at the 5′ and 3′ ends of its target genes

Author

Ruggieri, Valentino, Alexiou, Konstantinos, Morata, Jordi, Argyris, Jason, Pujol, Marta, Yano, Ryoichi, Nonaka, Satoko, Ezura, Hiroshi, Cigliano, Riccardo Aiese, Sanseverino, Walter, Puigdomenech, Pere, Casacuberta, Josep, Kirienko, Anna, Porozov, Yuri, Malkov, Nikita, Akhtemova, Gulnara, Le Signor, Christine, Thompson, Richard, Saffray, Christine, Dalmais, Marion, Tikhonovich, Igor, Dolgikh, Elena, Boucheham, Anouar, Sommard, Vivien, Zehraoui, Farida, Batouche, Mohamed, Israeli, David, Tahi, Fariza, Jacob, Pierre, Avni, Adi, Ligerot, Yasmine, De Saint Germain, Alexandre, Waldie, Tanya, Kadakia, Nikita, Pillot, Jean-Paul, Prigge, Michael, Aubert, Gregoire, Leyser, Ottoline, Estelle, Mark, Debellé, Frederic, Rameau, Catherine, GOUZY, Jerome, Badouin, Hélène, Lemainque, Arnaud, Vergne, Philippe, Moja, Sandrine, Choisne, Nathalie, Pont, Caroline, Carrere, Sebastien, Caissard, Jean-Claude, Couloux, Arnaud, Cottret, Ludovic, Aury, Jean-Marc, Szécsi, Judit, Madoui, Mohammed-Amin, Yang, Shu-Hua, Piola, Florence, Larrieu, Antoine, Perez, Magali, Labadie, Karine, Perrier, Lauriane, govetto, Benjamin, LABROUSSE, Yoan, Villand, Priscilla, Bardoux, Claudia, Boltz, Véronique, Lopez-Roques, Celine, Heitzler, Pascal, Vernoux, Teva, Quesneville, Hadi, Boualem, Adnane, Liu, Chang, Le Bris, Manuel, Salse, Jerome, Baudino, Sylvie, Wincker, Patrick, François, Léa, Verdenaud, Marion, Fu, Xiaopeng, Ruleman, Darcy, Dubois, Annick, Vandenbussche, Michiel, Raymond, Olivier, Just, Jérémy, Bendahmane, Mohammed, Giner, Ana, Pascual, Laura, Bourgeois, Michael, Gyetvai, Gabor, Rios, Pablo, Picó, Belén, Troadec, Christelle, Bendahmane, Abdel, Garcia-Mas, Jordi, MARTIN-HERNANDEZ, Ana Montserrat, Kim, Soonkap, Piquerez, Sophie, Ramirez-Prado, Juan, Mastorakis, Emmanouil, Veluchamy, Alaguraj, Latrasse, David, Manza-Mianza, Deborah, Brik-Chaouche, Rim, Huang, Ying, Rodriguez-Granados, Natalia, Concia, Lorenzo, Blein, Thomas, Citerne, Sylvie, Bendahmane, Abdelhafid, Bergounioux, Catherine, Crespi, Martin, Mahfouz, Magdy, Raynaud, Cécile, Hirt, Heribert, Ntoukakis, Vardis, BENHAMED, Moussa, Centre for Research in Agricultural Genomics (CRAG), IRTA, Center for Research in Agricultural Genomics, University of Tsukuba, Sequentia Biotech SL, LAboratoire PLasma et Conversion d'Energie (LAPLACE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Agroécologie [Dijon], Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), All-Russia Research Institute for Agricultural Microbiology, University Salah Boubnider Constantine 3, Laboratoire d'Informatique de Paris-Nord (LIPN), Université Sorbonne Paris Cité (USPC)-Institut Galilée-Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), LIRE laboratory, Constantine, University of Constantine, GENETHON 3, Université Paris Saclay (COmUE), Tel Aviv University [Tel Aviv], Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Sainsbury Laboratory, University of Cambridge [UK] (CAM), University of California [San Diego] (UC San Diego), University of California, Laboratoire de chimie organique et organométallique (LCOO), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), Division of Biology [La Jolla], University of California-University of California, UMR 0441 INRA / CNRS : Laboratoire de Biologie moléculaire des relations plantes-microorganismes, Institut National de la Recherche Agronomique (INRA), Laboratoire des interactions plantes micro-organismes (LIPM), Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Sexe et évolution, Département PEGASE [LBBE] (PEGASE), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales (LBVPAM), Université Jean Monnet [Saint-Étienne] (UJM), Unité de Recherche Génomique Info (URGI), Génétique Diversité et Ecophysiologie des Céréales (GDEC), Institut National de la Recherche Agronomique (INRA)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Département de chirurgie, CRLCC Val d'Aurelle - Paul Lamarque, Génomique métabolique (UMR 8030), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE), Reproduction et développement des plantes (RDP), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Centre for Plant Integrative Biology [Nothingham] (CPIB), University of Nottingham, UK (UON), Institut de Génomique d'Evry (IG), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), GeT PlaGe, Genotoul, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sun Yat-Sen University [Guangzhou] (SYSU), Institut Méditerranéen d'Ecologie et de Paléoécologie (IMEP), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Avignon Université (AU)-Centre National de la Recherche Scientifique (CNRS), Huazhong Agricultural University, Division of Biology [Pasadena], California Institute of Technology (CALTECH), Unité de recherche Génétique et amélioration des fruits et légumes (GAFL), Génétique et Ecophysiologie des Légumineuses à Graines (UMRLEG) (UMR 102), Etablissement National d'Enseignement Supérieur Agronomique de Dijon (ENESAD)-Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Universitat Politecnica de Valencia (UPV), Institute of Agrifood Research and Technology (IRTA), Institut de Recerca i Tecnologia Agroalimentaries, King Abdullah University of Science and Technology (KAUST), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), School of Economics and Management [Beijing] (BUAA), Beihang University, Institut de biotechnologie des plantes (IBP), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Warwick [Coventry], AgroParisTech, and ANR-18-CE20-0015,EPICLIPSE,Dynamique des marques épigénétiques dans les cellules hôtes infectées et subversion de l'épigénome par le pathogène.(2018)

Subjects
0106 biological sciences, Transcription, Genetic, AcademicSubjects/SCI00010, [SDV]Life Sciences [q-bio], Arabidopsis, Biology, Genes, Plant, 01 natural sciences, Histones, 03 medical and health sciences, Gene Expression Regulation, Plant, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Genetics, Homeostasis, Plant Immunity, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Epigenetics, Promoter Regions, Genetic, QH426, ComputingMilieux_MISCELLANEOUS, Histone Acetyltransferases, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Arabidopsis Proteins, Lysine, Gene regulation, Chromatin and Epigenetics, Acetylation, Biotic stress, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, Cell biology, Chromatin, enzymes and coenzymes (carbohydrates), Histone, Acetyltransferase, Transcription Coactivator, biology.protein, 5' Untranslated Regions, Salicylic Acid, 010606 plant biology & botany
Abstract

The modification of histones by acetyl groups has a key role in the regulation of chromatin structure and transcription. The Arabidopsis thaliana histone acetyltransferase GCN5 regulates histone modifications as part of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) transcriptional coactivator complex. GCN5 was previously shown to acetylate lysine 14 of histone 3 (H3K14ac) in the promoter regions of its target genes even though GCN5 binding did not systematically correlate with gene activation. Here, we explored the mechanism through which GCN5 controls transcription. First, we fine-mapped its GCN5 binding sites genome-wide and then used several global methodologies (ATAC-seq, ChIP-seq and RNA-seq) to assess the effect of GCN5 loss-of-function on the expression and epigenetic regulation of its target genes. These analyses provided evidence that GCN5 has a dual role in the regulation of H3K14ac levels in their 5′ and 3′ ends of its target genes. While the gcn5 mutation led to a genome-wide decrease of H3K14ac in the 5′ end of the GCN5 down-regulated targets, it also led to an increase of H3K14ac in the 3′ ends of GCN5 up-regulated targets. Furthermore, genome-wide changes in H3K14ac levels in the gcn5 mutant correlated with changes in H3K9ac at both 5′ and 3′ ends, providing evidence for a molecular link between the depositions of these two histone modifications. To understand the biological relevance of these regulations, we showed that GCN5 participates in the responses to biotic stress by repressing salicylic acid (SA) accumulation and SA-mediated immunity, highlighting the role of this protein in the regulation of the crosstalk between diverse developmental and stress-responsive physiological programs. Hence, our results demonstrate that GCN5, through the modulation of H3K14ac levels on its targets, controls the balance between biotic and abiotic stress responses and is a master regulator of plant-environmental interactions.

Published
2020
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8. ACS Sustainable Chemistry & Engineering / A Unified Method for the Recovery of Metals from Chalcogenides

Author

Bevan, Francesca, Galeb, Hanaa, Black, Alexander, Pateli, Ioanna Maria, Allen, Jack, Perez, Magali, Feldmann, Jörg, Harris, Robert, Jenkin, Gawen, Abbott, Andrew, Hartley, Jennifer, Bevan, Francesca, Galeb, Hanaa, Black, Alexander, Pateli, Ioanna Maria, Allen, Jack, Perez, Magali, Feldmann, Jörg, Harris, Robert, Jenkin, Gawen, Abbott, Andrew, and Hartley, Jennifer

Abstract

Metal chalcogenides are ubiquitous starting materials for the extraction of metals from both primary and secondary sources. In this study, it is shown that chalcogenide compounds are electrochemically active and can be solubilized from solid powders by electrochemical oxidation in a deep eutectic solvent. Importantly, the metal ions released into solution were unaffected by the type of chalcogenide present in the initial compound, maintaining the same speciation as would be obtained from dissolution of a chloride salt. Therefore, metals can be recovered by the same process from mixtures of chalcogenides. The chalcogenides form a mixture of oxyanions in the + IV and + VI oxidation states, which are separable via standard processes., NE/M010848/1 FIRG005 FIRG006 KAU1526, Europäische Kommission 721385, Version of record

Published
2021
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11. Additional file 5 of Wheat chromatin architecture is organized in genome territories and transcription factories

Author

Concia, Lorenzo, Alaguraj Veluchamy, Ramirez-Prado, Juan S., Azahara Martin-Ramirez, Huang, Ying, Perez, Magali, Domenichini, Severine, Granados, Natalia Y. Rodriguez, Soonkap Kim, Blein, Thomas, Duncan, Susan, Pichot, Clement, Manza-Mianza, Deborah, Juery, Caroline, Paux, Etienne, Moore, Graham, Hirt, Heribert, Bergounioux, Catherine, Crespi, Martin, Magdy M. Mahfouz, Abdelhafid Bendahmane, Liu, Chang, Hall, Anthony, Raynaud, Cécile, Latrasse, David, and Benhamed, Moussa

Abstract

Additional file 5: Review history.

Published
2020
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12. Additional file 1 of DNA polymerase epsilon is required for heterochromatin maintenance in Arabidopsis

Author

Bourguet, Pierre, López-González, Leticia, Gómez-Zambrano, Ángeles, Pélissier, Thierry, Hesketh, Amy, Potok, Magdalena E., Marie-Noëlle Pouch-Pélissier, Perez, Magali, Ines, Olivier Da, Latrasse, David, White, Charles I., Jacobsen, Steven E., Benhamed, Moussa, and Mathieu, Olivier

Abstract

Additional file 1: Figure S1. Release of transcriptional silencing in three new pol2a mutants. Figure S2. Contribution of H3K27me3 in POL2A-dependent gene silencing. Figure S3. POL2A is required for heterochromatin over-replication in atxr5/6. Figure S4. DNA repeats, H3K27me1 and H3K9me2 at pol2a-12 chromocenters. Figure S5. DNA methylation and H3K9me2 profiles in pol2a mutants. Figure S6. Comparison of pol2a and fas2 molecular phenotypes. Figure S7. Changes in small RNA accumulation in pol2a mutants. Figure S8. Characterization of pol2a cmt3 double mutants. Figure S9. DNA methylation profiles in mutant and drug contexts of replicative stress. Figure S10. Comparison of sequencing replicates.

Published
2020
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13. Additional file 1 of Wheat chromatin architecture is organized in genome territories and transcription factories

Author

Concia, Lorenzo, Alaguraj Veluchamy, Ramirez-Prado, Juan S., Azahara Martin-Ramirez, Huang, Ying, Perez, Magali, Domenichini, Severine, Granados, Natalia Y. Rodriguez, Soonkap Kim, Blein, Thomas, Duncan, Susan, Pichot, Clement, Manza-Mianza, Deborah, Juery, Caroline, Paux, Etienne, Moore, Graham, Hirt, Heribert, Bergounioux, Catherine, Crespi, Martin, Magdy M. Mahfouz, Abdelhafid Bendahmane, Liu, Chang, Hall, Anthony, Raynaud, Cécile, Latrasse, David, and Benhamed, Moussa

Abstract

Additional file 1. Supplementary figures.

Published
2020
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14. Liberation of selenium from alteration of the Bowland Shale Formation: evidence from the Mam Tor landslide

Author

Parnell, John, Bullock, Liam, Armstrong, Joseph, and Perez, Magali

Abstract

The Bowland Shale Formation is anomalously rich in selenium (Se) at levels an order of magnitude greater than other black shales. The Mam Tor landslide, Derbyshire, England, offers an opportunity to measure whether the Se anomaly is conferred to the alteration products formed by oxidative water flow through the shale. Selenium in the shale is concentrated in diagenetic pyrite. Alteration of the shale causes decomposition of the pyrite to iron oxyhydroxide, which is carried in colloidal form (ochre) by springs draining the landslide. The iron oxyhydroxide contains anomalously high Se, and anomalously high Se was measured in water ponded where the ochre precipitated, although not in flowing groundwater. Other trace elements including cadmium and thallium also occur at concentrations higher than in other ochres. Given the widespread nature of the Se anomaly in the Bowland Shale Formation and equivalents across Britain and Ireland, any alteration products derived from workings through the shale should be disposed of with care.

Published
2018

15. Selenium and tellurium resources in Kisgruva Proterozoic volcanogenic massive sulphide deposit (Norway)

Author

Bullock, Liam A., Perez, Magali, Armstrong, Joseph G., Parnell, John, Still, John, and Feldmann, Joerg

Abstract

The former mining site at Kisgruva near Kongsberg, Norway, is primarily composed of worked sulphide ore deposits, of hydrothermal origin, which occur within Precambrian metamorphic basement. Though the original targets at the Kisgruva mine site were extraction of copper (Cu), sulphur (S) and iron (Fe), the sulphide ore also contains exceptionally high concentrations of selenium (Se) and tellurium (Te), hosted within selenides (clausthalite and minor naumannite) and tellurides (hessite and minor altaite and tellurobismuthite). Both Se and Te are also present within the sulphide ore in pyrite and chalcopyrite, which contain exceptionally high concentrations of up to 688 ppm Se and 81 ppm Te. Additionally, oxidative weathering of the exposed bedrock has resulted in the accumulation of hyper-enriched, unconsolidated weathered crust deposits at surface (Se up to 1590 ppm; Te up to 63 ppm), containing selenite (SeO3 2−) and tellurite (TeO3 2−) ions. Concentrations of Se and Te are subsequently higher in the weathering products than in the sulphide ore, due to fixation on to organic matter (∼0.4% in weathered ore crusts), jarosite (formed from oxidation of sulphides from the primary ore), ferric oxide and hydroxide phases (goethite and haematite). Increasing demand for Se and Te to use in green technologies has led to the reassessment of these orebodies and their associated weathered ore crust deposits. Though these elements are currently considered mining contaminants, this and similar sites may be of future economic importance, particularly as demand for Se and Te continues to rise.

Published
2018

16. High selenium in the Carboniferous Coal Measures of Northumberland, north east England

Author

Bullock, Liam A., Parnell, John, Perez, Magali, Armstrong, Joseph G., Feldmann, Joerg, and Boyce, Adrian J.

Subjects
technology, industry, and agriculture, complex mixtures, respiratory tract diseases
Abstract

The Carboniferous Lower and Middle Coal Measures coals of the Northumberland Coalfield are anomalously rich in selenium (Se) content (up to 62 ppm) compared to the averages for the common UK and worldwide coals. As well as posing an environmental toxicity threat, Se is now regarded as an important resource for alloys, photovoltaic products and nanotechnologies, and high Se coals in North East England offer an opportunity to assess the Se means of occurrence, origins, transport mechanisms and enrichment in coals. At least two generations of pyrite host high Se in the sampled coal seams: microbial-formed disseminated pyrite (both cubic and framboidal in habit) and later cleat-filling pyrite, identified by petrographic observations, laser ablation methods and sulphur isotope compositions. There is a notable Se enrichment of up to 250 ppm in later formed cleat-filling pyrite. Trace element enrichment may have been sourced and influenced by seawater distribution during diagenesis, and localised dykes and deformation may have acted as an enrichment mechanism for sampled seams in the region. The high Se coals in Northumberland may provide a potential E tech element source and should be considered and carefully managed as coal mining and production are reduced in the area. The study also highlights the nature of Se enrichment in pyritic coals affected by cleat formation and multiple episodes of mineralisation, important as critical element demand continues to increase worldwide.

Published
2018

18. A study of selenoproteins in atlantic salmon (Salmo salar) using hyphenated mass spectrometry and bioinformatics

Author

Sele, Veronika, Perez, Magali, Raab, Andrea, Mariotti, Marco, Krupp, Eva, Feldmann, Joerg, Sloth, Jens Jørgen, Ørnsrud, Robin, Berntssen, Marc H. G., Rasinger, Josef D., Sele, Veronika, Perez, Magali, Raab, Andrea, Mariotti, Marco, Krupp, Eva, Feldmann, Joerg, Sloth, Jens Jørgen, Ørnsrud, Robin, Berntssen, Marc H. G., and Rasinger, Josef D.

Abstract

Selenium (Se) is an essential micronutrient for vertebrates and fish. Se is central to the function of selenoproteins, which play key roles in many biological functions including redox signaling, antioxidant defense, hormone metabolism, and immune responses. The number and expression levels of selenoproteins vary between different animal species with teleost fish featuring a much higher number of selenoproteins compared to vertebrates. While selenoproteomes have been well described for many species, a comprehensive analysis of selenoproteins in Atlantic salmon (Salmo salar) has yet to be performed. With recent advances in bioinformatics it has become possible to predict selenoproteins using computational tools; however, these in silico predictions description require validation through analytical data. In the present study we applied gel electrophoresis with subsequent use of laser ablation coupled to inductively coupled plasma mass spectrometry (LA-ICP-MS), and tryptic digestion with subsequent analysis with high performance liquid chromatography (HPLC) coupled to both ICPMS and high-resolution tandem electrospray mass spectrometry (HR-ESI-MS) for the analysis of selenooproteins. Furthermore, we set out to combine theoretical selenoprotein predictions with hyphenated analytical techniques to characterize the selenoproteome of salmon liver tissue. The results and challenges related to the analytical work will be presented and the presentation will show how bioinformatics data can be combined with analytical data to study selenoproteomes in fish.

Published
2018

24. Empatía en el contexto romántico: diseño y validación de una medida

Author

Sanchez Aragon, Rozzana, Martinez Perez, Magali, Sanchez Aragon, Rozzana, and Martinez Perez, Magali

Abstract

La empatía en su naturaleza involucra una serie de nociones (Batson, 2009) cuyos énfasis van de menos a más en cuanto a dos elementos psicológicos fundamentales: la cognición y la emoción que se vinculan en uno u otro sentido, es decir, en un carácter de comprensión intelectual o imaginativa de la condición del otro sin experimentar realmente los sentimientos de esa persona (e.g., Hogan, 1969) o como una reacción emocional o simpatía en respuesta a los sentimientos o experiencias de otros (e.g., Mehrabian & Epstein, 1972). Dado el carácter inherentemente interaccional de la empatía, el contexto de la relación de pareja se vuelve sumamente interesante de explorar en virtud de ella, ya que precisamente este vínculo, incluye matices de emocionalidad y cognición muy particulares que favorecen el despliegue de dicha variable que implicará la integración de sus miembros en una lectura cognitivo-emocional característica y por tanto, determinará el grado de intimidad e inmediatez alcanzado por ellos. Ante esto, el propósito de este estudio fue diseñar y validar una medida de empatía hacia la pareja en una muestra no probabilística propositiva de 467 adultos de la Ciudad de México que contaban con una relación romántica. Los resultados muestran la obtención de cuatro factores clave en el entendimiento de la variable como lo son: toma de perspectiva, empatía cognoscitiva de las emociones, perturbación propia y compasión empática. Dichos factores mostraron validez de constructo y coeficientes alpha de Cronbach moderados y en su conjunto representa una contribución conceptual, metodológica y cultural al estudio de la variable en el contexto romántico.

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