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1. Tracking the Spread of the BA.2.86 Lineage in Italy Through Wastewater Analysis

Author: Veneri, C, Brandtner, D, Mancini, P, Bonanno Ferraro, G, Iaconelli, M, Suffredini, E, Petrillo, M, Leoni, G, Paracchini, V, Gawlik, B, Marchini, A, Torlontano, P, Aprea, G, Scattolini, S, Acciari, V, La Bianca, M, Cifarelli, R, Palma, A, Lauria, G, La Vecchia, G, Giordano, V, Cossentino, L, Pennino, F, Lombardi, A, Gentili, L, Angelini, P, Nasci, D, Alborali, G, Formenti, N, Guarneri, F, Fontani, N, Guercio, M, Mariuz, M, Trani, G, Pariani, A, De Lellis, L, Ancona, C, Barca, A, Serio, F, Giorgi, D, Ferrante, I, Capparuccini, V, Scicluna, M, Cersini, A, Pietrella, G, Nicosia, E, Grasselli, E, Izzotti, A, Tomesani, I, Bellisomi, M, Rosatto, S, Ammoni, E, Cereda, D, Bertasi, B, Losio, M, Oliva, D, Castiglioni, S, Schiarea, S, Binda, S, Primache, V, Pellegrinelli, L, Cocuzza, C, Musumeci, R, Bolognini, L, Filippetti, F, Paniccia', M, Briscolini, S, Magi, S, Grucci, A, Colitti, M, Ciccaglione, A, Montanaro, C, Griglio, B, Costa, A, Decastelli, L, Romano, A, Bianchi, M, Carraro, E, Pignata, C, Macrì, M, Bonetta, S, Albano, N, Di Vittorio, G, Mongelli, O, Apollonio, F, Triggiano, F, De Giglio, O, Montagna, M, Palermo, M, Maida, C, Mazzucco, W, Tramuto, F, De Grazia, S, Giammanco, G, Filizzolo, C, Purpari, G, Gucciardi, F, Ferrante, M, Agodi, A, Barchitta, M, Cala', P, Carducci, A, Verani, M, Federigi, I, Macrì, S, Federici, E, Petricciuolo, M, Carnevali, A, Russo, F, Pitter, G, Groppi, V, Rigoli, F, Zampini, M, Baldovin, T, Amoruso, I, Cadonna, M, Postinghel, M, Foladori, P, Zago, L, Stenico, A, Marco, M, Matteo, D, La Rosa, G, Veneri, C., Brandtner, D., Mancini, P., Bonanno Ferraro, G., Iaconelli, M., Suffredini, E., Petrillo, M., Leoni, G., Paracchini, V., Gawlik, B. M., Marchini, A., Torlontano, Paolo, Aprea, Giuseppe, Scattolini, Silvia, Acciari, Vicdalia Aniela, La Bianca, Michele, Cifarelli, Rosa Anna, Palma, Achille, Lauria, Giuseppe, La Vecchia, Giovanna, Giordano, Vincenzo, Cossentino, Luigi, Pennino, Francesca, Lombardi, Annalisa, Gentili, Lisa, Angelini, Paola, Nasci, Daniele, Alborali, Giovanni, Formenti, Nicoletta, Guarneri, Flavia, Fontani, Nadia, Guercio, Marco, Mariuz, Marika, Trani, Gabriella, Pariani, Anna, De Lellis, Laura, Ancona, Carla, Barca, Alessandra, Serio, Flavia, Giorgi, Doriana Antonella, Ferrante, Irene, Capparuccini, Valeria, Scicluna, Maria Teresa, Cersini, Antonella, Pietrella, Gabriele, Nicosia, Elena, Grasselli, Elena, Izzotti, Alberto, Tomesani, Irene, Bellisomi, Marta, Rosatto, Stefano, Ammoni, Emanuela, Cereda, Danilo, Bertasi, Barbara, Losio, Marina Nadia, Oliva, Desdemona, Castiglioni, Sara, Schiarea, Silvia, Binda, Sandro, Primache, Valeria, Pellegrinelli, Laura, Cocuzza, Clementina, Musumeci, Rosario, Bolognini, Luigi, Filippetti, Fabio, Paniccia', Marta, Briscolini, Sara, Magi, Silvia, Grucci, Annalisa, Colitti, Michele, Ciccaglione, Angela, Montanaro, Carmen, Griglio, Bartolomeo, Costa, Angela, Decastelli, Lucia, Romano, Angelo, Bianchi, Manila, Carraro, Elisabetta, Pignata, Cristina, Macrì, Manuela, Bonetta, Silvia, Albano, Nehludoff, Di Vittorio, Giuseppe, Mongelli, Onofrio, Apollonio, Francesca, Triggiano, Francesco, De Giglio, Osvalda, Montagna, Maria Teresa, Palermo, Mario, Maida, Carmelo Massimo, Mazzucco, Walter, Tramuto, Fabio, De Grazia, Simona, Giammanco, Giovanni Maurizio, Filizzolo, Chiara, Purpari, Giuseppa, Gucciardi, Francesca, Ferrante, Margherita, Agodi, Antonella, Barchitta, Martina, Cala', Piergiuseppe, Carducci, Annalaura, Verani, Marco, Federigi, Ileana, Macrì, Salvatore, Federici, Ermanno, Petricciuolo, Maya, Carnevali, Agnese, Russo, Francesca, Pitter, Gisella, Groppi, Vanessa, Rigoli, Franco, Zampini, Marco, Baldovin, Tatjana, Amoruso, Irene, Cadonna, Maria, Postinghel, Mattia, Foladori, Paola, Zago, Lorella, Stenico, Alberta, Marco, Morelli, Matteo, Dossena, La Rosa, G., Veneri, C, Brandtner, D, Mancini, P, Bonanno Ferraro, G, Iaconelli, M, Suffredini, E, Petrillo, M, Leoni, G, Paracchini, V, Gawlik, B, Marchini, A, Torlontano, P, Aprea, G, Scattolini, S, Acciari, V, La Bianca, M, Cifarelli, R, Palma, A, Lauria, G, La Vecchia, G, Giordano, V, Cossentino, L, Pennino, F, Lombardi, A, Gentili, L, Angelini, P, Nasci, D, Alborali, G, Formenti, N, Guarneri, F, Fontani, N, Guercio, M, Mariuz, M, Trani, G, Pariani, A, De Lellis, L, Ancona, C, Barca, A, Serio, F, Giorgi, D, Ferrante, I, Capparuccini, V, Scicluna, M, Cersini, A, Pietrella, G, Nicosia, E, Grasselli, E, Izzotti, A, Tomesani, I, Bellisomi, M, Rosatto, S, Ammoni, E, Cereda, D, Bertasi, B, Losio, M, Oliva, D, Castiglioni, S, Schiarea, S, Binda, S, Primache, V, Pellegrinelli, L, Cocuzza, C, Musumeci, R, Bolognini, L, Filippetti, F, Paniccia', M, Briscolini, S, Magi, S, Grucci, A, Colitti, M, Ciccaglione, A, Montanaro, C, Griglio, B, Costa, A, Decastelli, L, Romano, A, Bianchi, M, Carraro, E, Pignata, C, Macrì, M, Bonetta, S, Albano, N, Di Vittorio, G, Mongelli, O, Apollonio, F, Triggiano, F, De Giglio, O, Montagna, M, Palermo, M, Maida, C, Mazzucco, W, Tramuto, F, De Grazia, S, Giammanco, G, Filizzolo, C, Purpari, G, Gucciardi, F, Ferrante, M, Agodi, A, Barchitta, M, Cala', P, Carducci, A, Verani, M, Federigi, I, Macrì, S, Federici, E, Petricciuolo, M, Carnevali, A, Russo, F, Pitter, G, Groppi, V, Rigoli, F, Zampini, M, Baldovin, T, Amoruso, I, Cadonna, M, Postinghel, M, Foladori, P, Zago, L, Stenico, A, Marco, M, Matteo, D, La Rosa, G, Veneri, C., Brandtner, D., Mancini, P., Bonanno Ferraro, G., Iaconelli, M., Suffredini, E., Petrillo, M., Leoni, G., Paracchini, V., Gawlik, B. M., Marchini, A., Torlontano, Paolo, Aprea, Giuseppe, Scattolini, Silvia, Acciari, Vicdalia Aniela, La Bianca, Michele, Cifarelli, Rosa Anna, Palma, Achille, Lauria, Giuseppe, La Vecchia, Giovanna, Giordano, Vincenzo, Cossentino, Luigi, Pennino, Francesca, Lombardi, Annalisa, Gentili, Lisa, Angelini, Paola, Nasci, Daniele, Alborali, Giovanni, Formenti, Nicoletta, Guarneri, Flavia, Fontani, Nadia, Guercio, Marco, Mariuz, Marika, Trani, Gabriella, Pariani, Anna, De Lellis, Laura, Ancona, Carla, Barca, Alessandra, Serio, Flavia, Giorgi, Doriana Antonella, Ferrante, Irene, Capparuccini, Valeria, Scicluna, Maria Teresa, Cersini, Antonella, Pietrella, Gabriele, Nicosia, Elena, Grasselli, Elena, Izzotti, Alberto, Tomesani, Irene, Bellisomi, Marta, Rosatto, Stefano, Ammoni, Emanuela, Cereda, Danilo, Bertasi, Barbara, Losio, Marina Nadia, Oliva, Desdemona, Castiglioni, Sara, Schiarea, Silvia, Binda, Sandro, Primache, Valeria, Pellegrinelli, Laura, Cocuzza, Clementina, Musumeci, Rosario, Bolognini, Luigi, Filippetti, Fabio, Paniccia', Marta, Briscolini, Sara, Magi, Silvia, Grucci, Annalisa, Colitti, Michele, Ciccaglione, Angela, Montanaro, Carmen, Griglio, Bartolomeo, Costa, Angela, Decastelli, Lucia, Romano, Angelo, Bianchi, Manila, Carraro, Elisabetta, Pignata, Cristina, Macrì, Manuela, Bonetta, Silvia, Albano, Nehludoff, Di Vittorio, Giuseppe, Mongelli, Onofrio, Apollonio, Francesca, Triggiano, Francesco, De Giglio, Osvalda, Montagna, Maria Teresa, Palermo, Mario, Maida, Carmelo Massimo, Mazzucco, Walter, Tramuto, Fabio, De Grazia, Simona, Giammanco, Giovanni Maurizio, Filizzolo, Chiara, Purpari, Giuseppa, Gucciardi, Francesca, Ferrante, Margherita, Agodi, Antonella, Barchitta, Martina, Cala', Piergiuseppe, Carducci, Annalaura, Verani, Marco, Federigi, Ileana, Macrì, Salvatore, Federici, Ermanno, Petricciuolo, Maya, Carnevali, Agnese, Russo, Francesca, Pitter, Gisella, Groppi, Vanessa, Rigoli, Franco, Zampini, Marco, Baldovin, Tatjana, Amoruso, Irene, Cadonna, Maria, Postinghel, Mattia, Foladori, Paola, Zago, Lorella, Stenico, Alberta, Marco, Morelli, Matteo, Dossena, and La Rosa, G.
Abstract: The emergence of new SARS-CoV-2 variants poses challenges to global surveillance efforts, necessitating swift actions in their detection, evaluation, and management. Among the most recent variants, Omicron BA.2.86 and its sub-lineages have gained attention due to their potential immune evasion properties. This study describes the development of a digital PCR assay for the rapid detection of BA.2.86 and its descendant lineages, in wastewater samples. By using this assay, we analyzed wastewater samples collected in Italy from September 2023 to January 2024. Our analysis revealed the presence of BA.2.86 lineages already in October 2023 with a minimal detection rate of 2% which then rapidly increased, becoming dominant by January 2024, accounting for a prevalence of 62%. The findings emphasize the significance of wastewater-based surveillance in tracking emerging variants and underscore the efficacy of targeted digital PCR assays for environmental monitoring.
Published: 2024

2. The rapid spread of SARS-COV-2 Omicron variant in Italy reflected early through wastewater surveillance

Author: La Rosa, G, Iaconelli, M, Veneri, C, Mancini, P, Bonanno Ferraro, G, Brandtner, D, Lucentini, L, Bonadonna, L, Rossi, M, Grigioni, M, Suffredini, E, Bucciarelli, G, Torlontano, P, Aprea, G, La Bianca, M, Cifarelli, R, Palma, A, La Vecchia, G, Lauria, G, Brienza, R, Montenegro, P, D'Argenzio, A, Cossentino, L, Olivares, R, Pizzolante, A, Fusco, G, Tosco, A, Porta, A, Pennino, F, Maria, T, Angelini, P, De Lellis, L, Nasci, D, Alborali, G, Formenti, N, Guarneri, F, Fontani, N, Nani, G, Palumbo, F, Borlone, G, Guercio, M, Gentili, L, Mariuz, M, Trani, G, Pariani, A, Ancona, C, Giorgi, D, Ferrante, I, Monfrinotti, M, Riosa, S, Capparuccini, V, Scicluna, M, Cersini, A, Arizzi, M, Cecchini, G, Ottaviano, C, Nicosia, E, Grasselli, E, Allaria, G, Izzotti, A, Rosatto, S, Ammoni, E, Cereda, D, Losio, M, Bertasi, B, Aliscioni, A, Oliva, D, Castiglioni, S, Schiarea, S, Zuccato, E, Antonelli, M, Azzellino, A, Malpei, F, Turolla, A, Binda, S, Laura, P, Primache, V, Cocuzza, C, Franzetti, A, Bertanza, G, Callegari, M, Bolognini, L, Filippetti, F, Paniccia', M, Ciuti, F, Briscolini, S, Magi, S, Colitti, M, Montanaro, C, Cerroni, M, Griglio, B, Berruti, R, Cravero, M, Costa, A, Bianchi, M, Decastelli, L, Romano, A, Zuccon, F, Carraro, E, Pignata, C, Bonetta, S, Di Vittorio, G, Mongelli, O, De Giglio, O, Apollonio, F, Triggiano, F, Montagna, M, Ungaro, N, Palermo, M, Maida, C, Mazzucco, W, De Grazia, S, Giammanco, G, Purpari, G, Ferrante, M, Agodi, A, Barchitta, M, Cala', P, Carducci, A, Verani, M, Federigi, I, Lauretani, G, Muzio, S, Ramazzotti, M, Antonelli, A, Ricci, E, Santoro, G, Federici, E, Petricciuolo, M, Barigelli, S, Ruffier, M, Borney, F, Grange, E, Damasco, F, Russo, F, Pitter, G, Groppi, V, Rigoli, F, Zampini, M, Baldovin, T, Amoruso, I, Mengon, E, Cadonna, M, Postinghel, M, Pizzo, F, Schiavuzzi, A, Cutrupi, F, Foladori, P, Manara, S, Zago, L, Stenico, A, Prast, A, La Rosa G., Iaconelli M., Veneri C., Mancini P., Bonanno Ferraro G., Brandtner D., Lucentini L., Bonadonna L., Rossi M., Grigioni M., Suffredini E., Bucciarelli G., Torlontano P., Aprea G., La Bianca M., Cifarelli R. A., Palma A., La Vecchia G., Lauria G., Brienza R., Montenegro P., D'Argenzio A., Cossentino L., Olivares R., Pizzolante A., Fusco G., Tosco A., Porta A., Pennino F., Maria T., Angelini P., De Lellis L., Nasci D., Alborali G., Formenti N., Guarneri F., Fontani N., Nani G., Palumbo F., Borlone G., Guercio M., Gentili L., Mariuz M., Trani G., Pariani A., Ancona C., Giorgi D. A., Ferrante I., Monfrinotti M., Riosa S., Capparuccini V., Scicluna M. T., Cersini A., Arizzi M., Cecchini G., Ottaviano C., Nicosia E., Grasselli E., Allaria G., Izzotti A., Rosatto S., Ammoni E., Cereda D., Losio M. N., Bertasi B., Aliscioni A., Oliva D., Castiglioni S., Schiarea S., Zuccato E., Antonelli M., Azzellino A., Malpei F., Turolla A., Binda S., Laura P., Primache V., Cocuzza C., Franzetti A., Bertanza G., Callegari M. L., Bolognini L., Filippetti F., Paniccia' M., Ciuti F., Briscolini S., Magi S., Colitti M., Montanaro C., Cerroni M. G., Griglio B., Berruti R., Cravero M., Costa A., Bianchi M., Decastelli L., Romano A., Zuccon F., Carraro E., Pignata C., Bonetta S., Di Vittorio G., Mongelli O., De Giglio O., Apollonio F., Triggiano F., Montagna M. T., Ungaro N., Palermo M., Maida C. M., Mazzucco W., De Grazia S., Giammanco G., Purpari G., Ferrante M., Agodi A., Barchitta M., Cala' P., Carducci A., Verani M., Federigi I., Lauretani G., Muzio S., Ramazzotti M., Antonelli A., Ricci E., Santoro G., Federici E., Petricciuolo M., Barigelli S., Ruffier M., Borney F., Grange E., Damasco F., Russo F., Pitter G., Groppi V., Rigoli F., Zampini M., Baldovin T., Amoruso I., Mengon E., Cadonna M., Postinghel M., Pizzo F., Schiavuzzi A., Cutrupi F., Foladori P., Manara S., Zago L., Stenico A., Prast A. -M., La Rosa, G, Iaconelli, M, Veneri, C, Mancini, P, Bonanno Ferraro, G, Brandtner, D, Lucentini, L, Bonadonna, L, Rossi, M, Grigioni, M, Suffredini, E, Bucciarelli, G, Torlontano, P, Aprea, G, La Bianca, M, Cifarelli, R, Palma, A, La Vecchia, G, Lauria, G, Brienza, R, Montenegro, P, D'Argenzio, A, Cossentino, L, Olivares, R, Pizzolante, A, Fusco, G, Tosco, A, Porta, A, Pennino, F, Maria, T, Angelini, P, De Lellis, L, Nasci, D, Alborali, G, Formenti, N, Guarneri, F, Fontani, N, Nani, G, Palumbo, F, Borlone, G, Guercio, M, Gentili, L, Mariuz, M, Trani, G, Pariani, A, Ancona, C, Giorgi, D, Ferrante, I, Monfrinotti, M, Riosa, S, Capparuccini, V, Scicluna, M, Cersini, A, Arizzi, M, Cecchini, G, Ottaviano, C, Nicosia, E, Grasselli, E, Allaria, G, Izzotti, A, Rosatto, S, Ammoni, E, Cereda, D, Losio, M, Bertasi, B, Aliscioni, A, Oliva, D, Castiglioni, S, Schiarea, S, Zuccato, E, Antonelli, M, Azzellino, A, Malpei, F, Turolla, A, Binda, S, Laura, P, Primache, V, Cocuzza, C, Franzetti, A, Bertanza, G, Callegari, M, Bolognini, L, Filippetti, F, Paniccia', M, Ciuti, F, Briscolini, S, Magi, S, Colitti, M, Montanaro, C, Cerroni, M, Griglio, B, Berruti, R, Cravero, M, Costa, A, Bianchi, M, Decastelli, L, Romano, A, Zuccon, F, Carraro, E, Pignata, C, Bonetta, S, Di Vittorio, G, Mongelli, O, De Giglio, O, Apollonio, F, Triggiano, F, Montagna, M, Ungaro, N, Palermo, M, Maida, C, Mazzucco, W, De Grazia, S, Giammanco, G, Purpari, G, Ferrante, M, Agodi, A, Barchitta, M, Cala', P, Carducci, A, Verani, M, Federigi, I, Lauretani, G, Muzio, S, Ramazzotti, M, Antonelli, A, Ricci, E, Santoro, G, Federici, E, Petricciuolo, M, Barigelli, S, Ruffier, M, Borney, F, Grange, E, Damasco, F, Russo, F, Pitter, G, Groppi, V, Rigoli, F, Zampini, M, Baldovin, T, Amoruso, I, Mengon, E, Cadonna, M, Postinghel, M, Pizzo, F, Schiavuzzi, A, Cutrupi, F, Foladori, P, Manara, S, Zago, L, Stenico, A, Prast, A, La Rosa G., Iaconelli M., Veneri C., Mancini P., Bonanno Ferraro G., Brandtner D., Lucentini L., Bonadonna L., Rossi M., Grigioni M., Suffredini E., Bucciarelli G., Torlontano P., Aprea G., La Bianca M., Cifarelli R. A., Palma A., La Vecchia G., Lauria G., Brienza R., Montenegro P., D'Argenzio A., Cossentino L., Olivares R., Pizzolante A., Fusco G., Tosco A., Porta A., Pennino F., Maria T., Angelini P., De Lellis L., Nasci D., Alborali G., Formenti N., Guarneri F., Fontani N., Nani G., Palumbo F., Borlone G., Guercio M., Gentili L., Mariuz M., Trani G., Pariani A., Ancona C., Giorgi D. A., Ferrante I., Monfrinotti M., Riosa S., Capparuccini V., Scicluna M. T., Cersini A., Arizzi M., Cecchini G., Ottaviano C., Nicosia E., Grasselli E., Allaria G., Izzotti A., Rosatto S., Ammoni E., Cereda D., Losio M. N., Bertasi B., Aliscioni A., Oliva D., Castiglioni S., Schiarea S., Zuccato E., Antonelli M., Azzellino A., Malpei F., Turolla A., Binda S., Laura P., Primache V., Cocuzza C., Franzetti A., Bertanza G., Callegari M. L., Bolognini L., Filippetti F., Paniccia' M., Ciuti F., Briscolini S., Magi S., Colitti M., Montanaro C., Cerroni M. G., Griglio B., Berruti R., Cravero M., Costa A., Bianchi M., Decastelli L., Romano A., Zuccon F., Carraro E., Pignata C., Bonetta S., Di Vittorio G., Mongelli O., De Giglio O., Apollonio F., Triggiano F., Montagna M. T., Ungaro N., Palermo M., Maida C. M., Mazzucco W., De Grazia S., Giammanco G., Purpari G., Ferrante M., Agodi A., Barchitta M., Cala' P., Carducci A., Verani M., Federigi I., Lauretani G., Muzio S., Ramazzotti M., Antonelli A., Ricci E., Santoro G., Federici E., Petricciuolo M., Barigelli S., Ruffier M., Borney F., Grange E., Damasco F., Russo F., Pitter G., Groppi V., Rigoli F., Zampini M., Baldovin T., Amoruso I., Mengon E., Cadonna M., Postinghel M., Pizzo F., Schiavuzzi A., Cutrupi F., Foladori P., Manara S., Zago L., Stenico A., and Prast A. -M.
Abstract: The SARS-CoV-2 Omicron variant emerged in South Africa in November 2021, and has later been identified worldwide, raising serious concerns. A real-time RT-PCR assay was designed for the rapid screening of the Omicron variant, targeting characteristic mutations of the spike gene. The assay was used to test 737 sewage samples collected throughout Italy (19/21 Regions) between 11 November and 25 December 2021, with the aim of assessing the spread of the Omicron variant in the country. Positive samples were also tested with a real-time RT-PCR developed by the European Commission, Joint Research Centre (JRC), and through nested RT-PCR followed by Sanger sequencing. Overall, 115 samples tested positive for Omicron SARS-CoV-2 variant. The first occurrence was detected on 7 December, in Veneto, North Italy. Later on, the variant spread extremely fast in three weeks, with prevalence of positive wastewater samples rising from 1.0% (1/104 samples) in the week 5–11 December, to 17.5% (25/143 samples) in the week 12–18, to 65.9% (89/135 samples) in the week 19–25, in line with the increase in cases of infection with the Omicron variant observed during December in Italy. Similarly, the number of Regions/Autonomous Provinces in which the variant was detected increased from one in the first week, to 11 in the second, and to 17 in the last one. The presence of the Omicron variant was confirmed by the JRC real-time RT-PCR in 79.1% (91/115) of the positive samples, and by Sanger sequencing in 66% (64/97) of PCR amplicons. In conclusion, we designed an RT-qPCR assay capable to detect the Omicron variant, which can be successfully used for the purpose of wastewater-based epidemiology. We also described the history of the introduction and diffusion of the Omicron variant in the Italian population and territory, confirming the effectiveness of sewage monitoring as a powerful surveillance tool.
Published: 2022

3. COVID-19: opinions and behavior of Italian general population during the first epidemic phase

Author: Genovese, C., La Fauci, V., Di Pietro, A., Trimarchi, G., Odone, A., Casuccio, A., Costantino, C., Restivo, V., Fantini, M., Gori, D., Azzara, A., Deiana, G., Castaldi, S., Righi, E., Palandri, L., Panciroli, G., Bianco, A., Licata, F., Cosentino, S., Mistretta, A., Marranzano, M., Ragusa, R., Gabutti, G., Stefanati, A., Prato, R., Fortunato, F., Martinelli, D., Icardi, G., Panatto, D., Amicizia, D., Fabiani, L., Moretti, A., Di Risio, D., Siliquini, R., Voglino, G., Bert, F., Lorini, C., Bonaccorsi, G., Torre, I., Pennino, F., Pavia, M., Di Giuseppe, G., Paolantonio, A., Villari, P., Marzuillo, C., Messina, G., Rivieri, C., Nante, N., Majori, S., Tardivo, S., Moretti, F., D'Amato, S., Mazzitelli, F., Giunta, I., Lo Giudice, D., Panto, G., Signorelli, C., Squeri, R., Genovese, Cristina, La Fauci, Vincenza, Di Pietro, Angela, Trimarchi, Giuseppe, Odone, Anna, Casuccio, Alessandra, Costantino, Claudio, Restivo, Vincenzo, Fantini, Mariapia, Gori, Davide, Azara, Antonio, Deiana, Giovanna, Castaldi, Silvana, Righi, Elena, Palandri, Lucia, Panciroli, Giovanni, Bianco, Aida, Licata, Francesca, Cosentino, Sofia, Mistretta, Antonio, Marranzano, Marina, Ragusa, Rosalia, Gabutti, Giovanni, Stefanati, Armando, Prato, Rosa, Fortunato, Francesca, Martinelli, Domenico, Icardi, Giancarlo, Panatto, Donatella, Amicizia, Daniela, Fabiani, Leila, Moretti, Annalucia, Di Risio, Damiana, Siliquini, Roberta, Voglino, Gianluca, Bert, Fabrizio, Lorini, Chiara, Bonaccorsi, Guglielmo, Torre, Ida, Pennino, Francesca, Pavia, Maria, Di Giuseppe, Gabriella, Paolantonio, Andrea, Villari, Paolo, Marzuillo, Carolina, Messina, Gabriele, Rivieri, Cesare, Nante, Nicola, Majori, Silvia, Tardivo, Stefano, Moretti, Francesca, D'Amato, Smeralda, Mazzitelli, Francesco, Giunta, Ioselita, Lo Giudice, Daniela, Pantò, Giuseppe, Signorelli, Carlo, Squeri, Raffaele, Genovese C., La Fauci V., Di Pietro A., Trimarchi G., Odone A., Casuccio A., Costantino C., Restivo V., Fantini M., Gori D., Azzara A., Deiana G., Castaldi S., Righi E., Palandri L., Panciroli G., Bianco A., Licata F., Cosentino S., Mistretta A., Marranzano M., Ragusa R., Gabutti G., Stefanati A., Prato R., Fortunato F., Martinelli D., Icardi G., Panatto D., Amicizia D., Fabiani L., Moretti A., Di Risio D., Siliquini R., Voglino G., Bert F., Lorini C., Bonaccorsi G., Torre I., Pennino F., Pavia M., Di Giuseppe G., Paolantonio A., Villari P., Marzuillo C., Messina G., Rivieri C., Nante N., Majori S., Tardivo S., Moretti F., D'amato S., Mazzitelli F., Giunta I., Lo Giudice D., Panto G., Signorelli C., and Squeri R.
Subjects: risk perception, Male, knowledge, SARS-CoV-2, attitude, COVID-19, perception, population, attitude, COVID-19, knowledge, perception, population, risk perception, Attitude, Humans, Female, Public Health, Epidemics, Human
Abstract: Background and aim: On January 9, 2020, the World Health Organization (WHO) declared that Chinese health authorities had identified a new coronavirus strain never before isolated in humans, the 2019-nCoV later redefined SARS-CoV-2, that still today represent a public health problem. The present survey started on 10 February 2020 with the aim of a) assessing the risk perception in healthcare workers and young students, following the evolution of attitudes, perception and knowledge over time, b) provide useful information to the general population during survey. Results: A study sample consisting of 4116 Italian in-dividuals of both sexes was enrolled. High levels of risk perception, low perception of self-efficacy and low levels of knowledge scores (24.55 ± 5.76 SD) were obtained indicating the need for continuous population monitoring as well as further communication strategies carried out at institution levels. Conclusion: The results of the present study could help public health authorities in carrying out informative campaigns for general population and could be an important tool in evaluating public knowledge and misperceptions during the management of the COVID-19. (www.actabiomedica.it).
Published: 2022

4. A multicentre study on epidemiology and prevention of needle stick injuries among students of nursing schools

Author: Veronesi, L, Giudice, L, Agodi, A, Arrigoni, C, Baldovin, T, Barchitta, M, Benedetti, T, Caggiano, G, Cannizzaro, S G, De Giglio, O, D'Errico, M, Destri, S, Fiorentini, R, Gentile, L, Mannone, A, Mascipinto, S, Mercuri, M, Montagna, M T, Novati, R, Oriani, R, Ortolani, S, Pennino, F, Ripabelli, G, Rossini, A, Sammarco, M L, Sodano, L, Squeri, R, Tamarri, F, Tamburro, M, Torre, I, Troiani, S, Pasquarella, C, Veronesi, L, Giudice, L, Agodi, A, Arrigoni, C, Baldovin, T, Barchitta, M, Benedetti, T, Caggiano, G, Cannizzaro, SUSANNA GAIA, De Giglio, O, D'Errico, M, Destri, S, Fiorentini, R, Gentile, L, Mannone, A, Mascipinto, S, Mercuri, M, Montagna, Mt, Novati, R, Oriani, R, Ortolani, S, Pennino, F, Ripabelli, G, Rossini, A, Sammarco, Ml, Sodano, L, Squeri, R, Tamarri, F, Tamburro, M, Torre, I, Troiani, S, Pasquarella, C., Veronesi, L., Giudice, L., Agodi, A., Arrigoni, C., Baldovin, T., Barchitta, M., Benedetti, T., Caggiano, G., Cannizzaro, S. G., De Giglio, O., D'Errico, M., Destri, S., Fiorentini, R., Gentile, L., Mannone, A., Mascipinto, S., Mercuri, M., Montagna, M. T., Novati, R., Oriani, R., Ortolani, S., Pennino, F., Ripabelli, G., Rossini, A., Sammarco, M. L., Sodano, L., Squeri, R., Tamarri, F., Tamburro, M., Torre, I., and Troiani, S.
Subjects: Adult, Male, Schools, Nursing, Biological risk, Education, Internship, Needle stick injuries, Training, Nursing, Young Adult, Humans, Infortunio, Sex Distribution, Needlestick Injuries, Students, Schools, Formazione, Punture da ago, Rischio biologico, Tirocinio, Albania, Female, Internship and Residency, Italy, Middle Aged, Post-Exposure Prophylaxis, Students, Nursing, Environmental and Occupational Health, Infectious Diseases, Public Health, Environmental and Occupational Health, Needle stick injurie, Public Health
Abstract: Introduction. Among the health professions with a long period of training, the students of the Nursing Bachelor's Degree are the most exposed to biological risk resulting from accidents, in particular with needles and cutting edges. The aim of the study was to estimate the frequency and the circumstances for the occurrence of needle stick injuries, as a knowledge base for targeted prevention interventions. Methods. The study was carried out between May and July 2017 in 11 Universities in Italy and 1 in Albania (associated with the "Tor Vergata" University of Rome). An anonymous semi-structured questionnaire was proposed to 1st (second semester), 2nd and 3rd year students of Nursing Bachelor's Degree. Results. A total of 2742 questionnaires were collected. The average age of participants was 22.9 years (median 22, range 19-60 years), 73% of whom were females. A total of 381 injuries were reported. Three hundred and sixteen students (11.8%) underwent at least 1 injury (12.7% among females, 9.7% among males); 41 students declared two or more injuries; four students did not report the number of injuries occurred. The first injury occurred, as an average, 17 days after the start of the internship (median 15 days) and, in 25% of the cases, during the first 9 days. The highest percentage of accidents occurred during the first internship (25.3% of the total) and decreased with the progress of the training path. The injuries occurred in 38% of cases during drug preparation, 24% when disposing of sharp devices, 15% while re capping needles, 13% during blood sampling and 10% in other circumstances. In 51.2% of cases, the needle was not sterile. Among the nursing students who suffered a needle stick injury, 58.1% declared that they had performed the post-exposure prophylaxis. 96% of students stated to be vaccinated against Hepatitis B virus. Amongst the students who had their serological status checked (74%), 18% stated the antibody titre was not protective. 49.8% of students answered to have been trained in advance on the correct procedures to avoid needle stick and cutting edges injuries in each clinical ward attended, 41.2% referred that this occurred only in some wards and 10% in no ward at all. Conclusions. The results of this study show a high percentage of needle stick injuries in students of the Nursing Bachelor's Degree. Therefore, there is a need for careful reflection on the most effective methods of targeted training acquisition of knowledge, skills and behavioural models useful for the exercise of the profession.
Published: 2018

5. Predicting needlestick and sharps injuries in nursing students: Development of the SNNIP scale

Author: Bagnasco, A., Zanini, M., Catania, G., Watson, R., Hayter, M., Dasso, N., Dini, G., Agodi, A., Pasquarella, C., Zotti, C. M., Durando, P., Sasso, L., Barchitta, M., Maugeri, A., Favara, G., San Lio, R. M., Rossini, A., Squeri, R., Genovese, C., D'Amato, S., La Fauci, V., Tardivo, S., Moretti, F., Carli, A., Casini, B., Baggiani, A., Verani, M., Rita Giuliani, A., Fabiani, L., D'Eugenio, S., Boccia, G., Santoro, E., Battista Orsi, G., Napoli, C., Montesano, M., Berdini, S., Bertamino, E., Perre, A., Zerbetto, A., D'Errico, M., Ortolani, S., Mercuri, M., Traini, T., Santarelli, A., Fiorentini, R., Benedetti, T., Montagna, M., Mascipinto, S., Torre, I., Pennino, F., Schiavone, D., Maria Iannicelli, A., Tartaglia, E., Veronesi, L., Palandri, L., Miguel Morgado, M. S., Giudice, L., Arrigoni, C., Gentile, L., Bascape, B., Mura, I., Sotgiu, G., Barberis, I., Maria Bersi, F., Manca, A., Massa, E., Montecucco, A., Rahmani, A., Zacconi, S., Ricco, M., Magnavita, N., Di Prinzio, R. R., Torregrossa, M. V., Calamusa, G., Firenze, A., Bargellini, A., Ferri, P., Righi, E., Carraro, E., Borraccino, A., Traversi, D., Ottino, M. C., Baldovin, T., Torre, S. D., Sulaj, A., Bianco, A., Teti, V., Novati, R., Oriani, R., Magnavita N. (ORCID:0000-0002-0988-7344), Di Prinzio R. R., Bagnasco, A., Zanini, M., Catania, G., Watson, R., Hayter, M., Dasso, N., Dini, G., Agodi, A., Pasquarella, C., Zotti, C. M., Durando, P., Sasso, L., Barchitta, M., Maugeri, A., Favara, G., San Lio, R. M., Rossini, A., Squeri, R., Genovese, C., D'Amato, S., La Fauci, V., Tardivo, S., Moretti, F., Carli, A., Casini, B., Baggiani, A., Verani, M., Rita Giuliani, A., Fabiani, L., D'Eugenio, S., Boccia, G., Santoro, E., Battista Orsi, G., Napoli, C., Montesano, M., Berdini, S., Bertamino, E., Perre, A., Zerbetto, A., D'Errico, M., Ortolani, S., Mercuri, M., Traini, T., Santarelli, A., Fiorentini, R., Benedetti, T., Montagna, M., Mascipinto, S., Torre, I., Pennino, F., Schiavone, D., Maria Iannicelli, A., Tartaglia, E., Veronesi, L., Palandri, L., Miguel Morgado, M. S., Giudice, L., Arrigoni, C., Gentile, L., Bascape, B., Mura, I., Sotgiu, G., Barberis, I., Maria Bersi, F., Manca, A., Massa, E., Montecucco, A., Rahmani, A., Zacconi, S., Ricco, M., Magnavita, N., Di Prinzio, R. R., Torregrossa, M. V., Calamusa, G., Firenze, A., Bargellini, A., Ferri, P., Righi, E., Carraro, E., Borraccino, A., Traversi, D., Ottino, M. C., Baldovin, T., Torre, S. D., Sulaj, A., Bianco, A., Teti, V., Novati, R., Oriani, R., Magnavita N. (ORCID:0000-0002-0988-7344), and Di Prinzio R. R.
Abstract: Aim: To develop an instrument to investigate knowledge and predictive factors of needlestick and sharps injuries (NSIs) in nursing students during clinical placements. Design: Instrument development and cross-sectional study for psychometric testing. Methods: A self-administered instrument including demographic data, injury epidemiology and predictive factors of NSIs was developed between October 2018–January 2019. Content validity was assessed by a panel of experts. The instrument's factor structure and discriminant validity were explored using principal components analysis. The STROBE guidelines were followed. Results: Evidence of content validity was found (S-CVI 0.75; I-CVI 0.50–1.00). A three-factor structure was shown by exploratory factor analysis. Of the 238 participants, 39% had been injured at least once, of which 67.3% in the second year. Higher perceptions of “personal exposure” (4.06, SD 3.78) were reported by third-year students. Higher scores for “perceived benefits” of preventive behaviours (13.6, SD 1.46) were reported by second-year students.
Published: 2020

6. How much is tuberculosis screening practiced among italian university students? A cross-sectional study

Author: Montagna, M. T., Mascipinto, S., Bianchi, F. P., Auxilia, F., Baldovin, T., Bargellini, A., Boccia, G, Casini, B, Napoli, C., Novati, R, Odone, A., Orsi, G. B., Pasquarella, C., Ripabelli, G, Rossini, A., Squeri, R., Tardivo, S., Pennino, F., Torregrossa, M. V., Agodi, A., Barchitta, M., and GISIO-SItI, Group
Published: 2018

7. Epidemiologia e prevenzione delle ferite da punta negli studenti dei corsi di laurea in infermieristica. Risultati preliminari di uno studio multicentrico

Author: Veronesi, L., Agodi, A., Arrigoni, C., Baldovin, T., Barchitta, M., Benedetti, T., Cannizzaro, S. G., D’Errico, M., Destri, S., Diella, G., Fiorentini, R., Gentile, L., Giudice, L., Mannone, A., Mascipinto, S., Mercuri, M., Montagna, M. T., Novati, R., Oriani, R., Ortolani, S., Pennino, F., Ripabelli, G., Rossini, A., Sammarco, M. L., Shahinaj, E., Sodano, L., Squeri, R., Tamarri, F., Tamburro, M., Torre, I., Troiani, S., and Pasquarella, C.
Published: 2017

8. Legionella Indoor Air Contamination in Healthcare Environments

Author: Montagna, aEmail Author, M. T., Giglio, De, Cristina, O., bEmail Author, M. L., Albertini, cEmail Author, R., Pasquarella, Author, C. E., GISIO-SItI Working Group, AIA Working Group, SIMPIOS Working Group, Agodi, A, Coniglio, M., Baldovin, T. i., Spagnolo, A. M. j., D'Errico, M. M. k., Delia, S. A. l., Laganà, P. l., Giuliano, A. m., Liguori, G. n., Guida, M. n., Torre, I. n., Pennino, F. n., Diella, G. o., Divenuto, F. o., Rutigliano, S. o., Caggiano, G. o., Moro, M. p., Mura, I. q., Deriu, M. G. q., Napoli, C. r., Romano, Spica, Valeriani, V. r., Rossini, F. r., Privitera, A. r., Casini, G. s., Tardivo, B. s., Sembeni, S. t., Torregrossa, S. t., Cannova, M. V., Villafrate, L., and M. R.
Subjects: Air sampling, Legionella, Indoor air, Water source, Health Informatics, bioaerosol, indoor air, legionella, water, 030501 epidemiology, Legionella pneumophila, 03 medical and health sciences, 0302 clinical medicine, Environmental health, 030212 general & internal medicine, Bioaerosol, Water, Public Health, Environmental and Occupational Health, Health Policy, biology, Environmental and Occupational Health, Sampling (statistics), Bioaerosol, Indoor air, Legionella, Water, Public Health, Environmental and Occupational Health, Health Informatics, Health Policy, Contamination, biology.organism_classification, Environmental science, Public Health, 0305 other medical science
Abstract: Legionella spp. is a ubiquitous intracellular microorganism in aquatic environments both natural and artificial. Although Legionella pneumophila sg 1 and sg 6 are the main causes of disease, other species have recently been associated with cases of legionellosis. Since 2000, some international documents related to the control and prevention of Legionnaires’ disease have been issued, providing different environmental matrices’ sampling, but not for air. To date, the control on water mains is preferred; however, air sampling could be a useful tool for exposure evaluation. To sample biological particles in the air, active and passive methods can be used. Several studies have compared the values of microbial counts obtained with these sampling methods, attaining discordant results. Based on this scientific background and on the experience about Legionella spp. contamination and air microbial sampling in health care environments, GISIO-SItI, AIA, and SIMPIOS promoted two multicenter studies focused on identifying a standardized sampling protocol to detect the airborne contamination coming from water sources contaminated with Legionella spp.
Published: 2017

9. A multicenter study on Legionella air contamination in healthcare facilities: comparison of different sampling methods

Author: De Giglio, O., Montagna, M. T., Diella, G., Divenuto, F., Pacifico, C., Rutigliano, S., Cristina, M. L., Napoli, C., Agodi, A., Baldovin, T., Casini, B., Coniglio, M. A., D’Errico, M. M., Delia, A. S., Deriu, M. G., Guida, M., Laganà, P., Liguori, G., Moro, M., Mura, I., Pennino, F., Privitera, G., Romano Spica, V., Sembeni, S., Spagnolo, A. M., Tardivo, S., Torre, I., Valeriani, F., Albertini, R., Pasquarella, C., GISIO-SItI, Aia, and and SIMPIOS Working, Groups.
Published: 2017

10. Risk perception of acquiring vaccine preventable diseases in Italy: results from NAVIDAD Study

Author: Gualano, MR, primary, Voglino, G, additional, Castaldi, S, additional, Pennino, F, additional, Signorelli, C, additional, Masanotti, G, additional, Mogini, V, additional, Massimi, A, additional, Nante, N, additional, Olivero, E, additional, Rossello, P, additional, and Siliquini, R, additional
Published: 2018
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11. La contaminazione indoor da Legionella spp: risultati preliminari di una indagine multicentrica italiana Legionella spp contamination in indoor air: preliminary results of an italian multicenter study

Author: Montagna, M., Giglio, O., Napoli, C., Cristina, M., Deriu, M., Delia, S., Giuliano, A., Guida, M., Laganà, P., Liguori, G., Mura, I., Pennino, F., Rossini, A., Tardivo, S., Torre, I., Villafrate, M., Albertini, R., Pasquarella, C., CANNOVA, Lucia, TORREGROSSA, Maria Valeria, Montagna, M., Giglio, O., Napoli, C., Cannova, L., Cristina, M., Deriu, M., Delia, S., Giuliano, A., Guida, M., Laganà, P., Liguori, G., Mura, I., Pennino, F., Rossini, A., Tardivo, S., Torre, I., Torregrossa, M., Villafrate, M., Albertini, R., and Pasquarella, C.
Subjects: legionella, aria,acqua, Settore MED/42 - Igiene Generale E Applicata
Published: 2014

12. [Legionella spp. contamination in indoor air: preliminary results of an Italian multicenter study]

Author: Mt, Montagna, Osvalda De Giglio, Napoli C, Cannova L, Ml, Cristina, Mg, Deriu, Sa, Delia, Giuliano A, Guida M, Laganà P, Liguori G, Mura I, Pennino F, Rossini A, Tardivo S, Torre I, Mv, Torregrossa, Villafrate MR, Albertini R, Pasquarella C, torregrossa m.v., Montagna Maria, Teresa, De Giglio, Osvalda, Napoli, Christian, Cannova, Lucia, Cristina Maria, Luisa, Deriu Maria, Grazia, Delia Santi, Antonino, Giuliano, Ada, Guida, Marco, Lagana, Pasqualina, Liguori, Giorgio, Mura, Ida, Pennino, Francesca, Rossini, Angelo, Tardivo, Stefano, Torre, Ida, Torregrossa Maria, Valeria, Villafrate Maria, Rosaria, Albertini, Roberto, and Pasquarella, Cesira
Subjects: Air Microbiology, Legionella, Legionella, indoor, aria, indoor air, Settore MED/42 - Igiene Generale E Applicata, Waste Disposal, Fluid, contamination, Air Pollution, Humans, Indoor, Toilet Facilities, Cross Infection, Legionellosis, legionella spp, Legionella, aria, acqua, SAS, IMA, Waste Disposal, bacterial infections and mycoses, aria, Hospitals, respiratory tract diseases, Bacterial Typing Techniques, Italy, Air Pollution, Indoor, Environmental Monitoring, Water Microbiology, bacteria, Fluid
Abstract: Obiettivo. Rilevare la presenza di Legionella spp. nell’aria attraverso un protocollo standardizzato, a fianco dei tradizionali metodi impiegati per la rete idrica. Disegno. In dieci strutture sanitarie è stato selezionato un bagno, la cui acqua presentava una contaminazione da Legionella >1.000 unità formanti colonie (ufc)/litro. La contaminazione dell’aria è stata valutata tramite campionamento attivo (Surface Air System, SAS) e passivo, impiegando piastre di sedimentazione per la valutazione dell’Indice Microbico Aria (Index of Microbial Air, IMA). I campionamenti sono stati effettuati per 8 ore consecutive, a circa 1 m dal pavimento e a 50 cm dal rubinetto. Con il campionamento attivo, 200 litri di aria erano aspirati ogni 12 min, dopo flussaggio dell’acqua per 2 min. Il valore IMA era calcolato come valore medio di ufc/16 piastre esposte nel corso del campionamento (due per ogni ora). La contaminazione dell’acqua è stata valutata al tempo zero, dopo 4 e 8 ore, secondo le procedure descritte nelle linee guida del 2000. Risultati. Legionella spp. è stata rilevata nell’aria di tre strutture sanitarie (in una con il metodo SAS, in due con il metodo IMA), la cui contaminazione idrica è risultata compresa tra 1.100 e 43.000 ufc/l (mediana=40.000). I restanti sette ospedali hanno riportato una contaminazione da Legionella solo nell’acqua (mediana=8.000; range 1.200-70.000 ufc/l), mai nell’aria circostante. Conclusioni. I nostri dati suggeriscono che la valutazione della contaminazione ambientale da Legionella spp, quando effettuata esclusivamente attraverso il campionamento dell’aria, può portare a una sottostima del rischio, anche in presenza di un elevato grado di contaminazione idrica
Published: 2015

13. Ricerca di Legionella spp in aerosol: metodi di campionamento a confronti

Author: Montagna, Mt, Degiglio, O, Agodi, A, Baldovin, T, Caggiano, G, Casini, B, Coniglio, MARIA ANNA, Cristina, Ml, Delia, Sa, Deriu, Mg, Diella, G, Guida, M, Laganà, P, Liguori, G, Mura, I, Pennino, F, Privitera, G, Romano Spica, V, Rutigliano, S, Sembeni, S, Spagnolo, Am, Tardivo, S, Torre, I, Valeriani, F, Moro, M, D'Errico, Mm, Albertini, R, Pasquarella, C, Gdl GISIO SITI, Gdl, Aia, and Gdl, Simpios
Subjects: IMA, Aria, Coriolis, Legionella, SAS
Published: 2015

14. Ricerca di Legionella spp. in aerosol: metodi di campionamento a confronto

Author: Montagna Maria Teresa, De Giglio Osvalda, Agodi, Antonella, Baldovin, Tatiana, Caggiano, G, Casini, Beatrice, Coniglio Maria Anna, Cristina Maria Luisa, Delia, Santi Antonino, Deriu, Mg, Diella, G, Guida, Marco, Lagana', Pasqualina, Liguori, Giorgio, Mura, Ida, Pennino, F, Privitera, G, Romano Spica Vincenzo, Rutigliano, S, Sembeni, S, Spagnolo Anna Maria, Tardivo, S, Torre, I, Valeriani, F, Moro, M, D’Errico, Mm, Albertini, R, and Pasquarella, Cesira
Subjects: IMA, Coriolis, Legionella, aria, Coriolis, SAS, IMA, Legionella, SAS, aria
Published: 2015

15. Microbial environmental contamination in Italian dental clinics: A multicenter study yielding recommendations for standardized sampling methods and threshold values

Author: Pasquarella, C., Veronesi, L., Napoli, C., Castiglia, P., Liguori, G., Rizzetto, Rolando, Torre, I., Righi, E., Farruggia, P., Tesauro, M., Torregrossa, M. V., Montagna, M. T., Colucci, M. E., Gallè, F., Masia, M. D., Strohmenger, L., Bergomi, M., Tinteri, Carola, Panico, M., Pennino, F., Cannova, L., Tanzi, M., Working, S. I., Cesira, Pasquarella, Licia, Veronesi, Christian, Napoli, Paolo, Castiglia, Giorgio, Liguori, Rolando, Rizzetto, Torre, Ida, Elena, Righi, Patrizia, Farruggia, Marina, Tesauro, Maria V., Torregrossa, Maria T., Montagna, Maria E., Colucci, Francesca, Gallè, Maria D., Masia, Laura, Strohmenger, Margherita, Bergomi, Carola, Tinteri, Manuela, Panico, Pennino, Francesca, Lucia, Cannova, and Marialuisa, Tanzi
Subjects: Environmental Engineering, air, Legionella, water, Air Microbiology, Dentistry, Total Viable Count, surfaces, Dental Equipment, dental unit water system, Toxicology, Tap water, Environmental monitoring, Environmental Chemistry, Medicine, Humans, Threshold Limit Values, Waste Management and Disposal, Air Microbiology, Dental Clinics, Dental Equipment, microbiology, Environmental Monitoring, standards, Equipment Contamination, Humans, Italy, Threshold Limit Values, Water Microbiology, biology, business.industry, Dental Clinics, microbiology, Environmental Monitoring, Italy, Equipment Contamination, Water Microbiology, Liter, Contamination, dental clinic, microbiological contanimation, biology.organism_classification, Pollution, standards, business
Abstract: A microbiological environmental investigation was carried out in ten dental clinics in Italy. Microbial contamination of water, air and surfaces was assessed in each clinic during the five working days, for one week per month, for a three-month period. Water and surfaces were sampled before and after clinical activity; air was sampled before, after, and during clinical activity. A wide variation was found in microbial environmental contamination, both within the participating clinics and for the different sampling times. Before clinical activity, microbial water contamination in tap water reached 51,200cfu/mL (colony forming units per milliliter), and that in Dental Unit Water Systems (DUWSs) reached 872,000cfu/mL. After clinical activity, there was a significant decrease in the Total Viable Count (TVC) in tap water and in DUWSs. Pseudomonas aeruginosa was found in 2.38% (7/294) of tap water samples and in 20.06% (59/294) of DUWS samples; Legionella spp. was found in 29.96% (89/297) of tap water samples and 15.82% (47/297) of DUWS samples, with no significant difference between pre- and post-clinical activity. Microbial air contamination was highest during dental treatments, and decreased significantly at the end of the working activity (p
Published: 2012

16. La contaminazione microbica dell’aria negli ambulatori odontoiatrici: risultati di uno studio multicentrico condotto in 9 città italiane

Author: Pasquarella, C, Veronesi, L, Castiglia, P, Liguori, Giorgio, Montagna, Mt, Napoli, C, Rizzetto, R, Torre, I, Deriu, Mg, Strohmenger, L, DI ONOFRIO, Valeria, Tesauro, M, Colucci, Me, Righi, E, Bergomi, M, Farruggia, P, Torregrossa, Mv, Tinteri, C, Panico, M, Pennino, F, Cannova, L, and Tanzi, Ml
Subjects: riuniti odontoiatrici, carica batterica totale, contaminazione microbica dell'aria, legionella pneumophila
Published: 2011

17. La qualità microbiologica dell’acqua negli ambulatori odontoiatrici: indagine in 9 città Italiane

Author: Tanzi, M, Veronesi, L, Castiglia, P, Liguori, G, Montagna, Mt, Napoli, C, Rizzetto, R, Torre, I, Deriu, Mg, Strohmenger, L, Gallè, Tesauro, M, Colucci, Me, Righi, Elena, Bergomi, Margherita, Farruggia, P, Torregrossa, Mv, Tinteri, C, Panico, M, Pennino, F, Cannova, L, Pasquarella, C, and Gruppo di Lavoro SItI 'Igiene in Odontoiatria', E.
Subjects: acqua, contaminazione microbiologica, legionella pnuemophila, carica batterica totale, Pseudomonas aeruginosa, riunito odontoiatrico
Published: 2011

18. Antimicrobial susceptibility and glycopeptide-resistance of enterococci in vegetables

Author: Torre, I., Pennino, F., Diana, M. V., Marco, G., Anna Maria Trotta, Borriello, T., Troiano, E., Torre, Ida, Pennino, Francesca, Diana, M. V., De Marco, G., Borriello, T., Trotta, A. M., and Troiano, E.
Subjects: lcsh:Public aspects of medicine, GRE, lcsh:R, DOAJ:Public Health, lcsh:Medicine, vegetable, lcsh:RA1-1270, antimicrobial-resistance, biochemical phenomena, metabolism, and nutrition, Enterococci, DOAJ:Health Sciences, ENTEROCOCCI
Abstract: Background: Vancomycin-resistant enterococci (VRE), often responsible for nosocomial infections, have frequently been isolated from animal and vegetable foods. In our study we evaluated the antibiotic susceptibility of enterococci isolated from eight types of vegetables randomly selected from grocery stores in Naples.Methods: From July to November 2008, we analyzed 150 samples: the bacteria were isolated with standardized methods and antibiotic susceptibility was determined using the disc diffusion method. The resistance to vancomycin versus other antibiotics was assessed by the Kappa test.Results: 70% of the samples, mainly parsley (96.2%), showed enterococci. Of these, 59.1% belonged to the species Enterococcus faecium. Strains resistant to vancomycin and teicoplanin were isolated respectively in 47.6% and 49.5% of the samples: the first one mainly in curly endive (72.7%) and the second one in parsley (76.9%). Almost all the isolated strains showed resistance to methicillin (89%), kanamycin (82%) and cephalothin (68%). The Kappa test showed statistically significant associations between resistance to vancomycin and resistance to teicoplanin, erythromycin, methicillin, tetracycline and chloramphenicol.Conclusions: Because of the possible involvement of food in the transmission of resistant micro-organisms to human intestinal microbiota, our data may provide the basis for future studies.
Published: 2010

19. Studio multicentrico italiano sulla Legionellosi. Contaminazione ambientale da Legionella spp in strutture pubbliche e private

Author: Borella, Paola, Leoni, E., Montagna, M. T., Romano Spica, V., Stancanelli, G., Triassi, M., Marchesi, Isabella, Bargellini, Annalisa, Cauteruccio, Laura, Sacchetti, R., Zanetti, F., Tatò, D., Napoli, C., Scaltriti, Stefania, Montegrosso, S., Pennino, F., and Boccia, S.
Subjects: Legionella, legionellosi, case, contaminazione ambientale, alberghi
Published: 2006

20. IL RISCHIO LEGIONELLOSI IN SOGGETTI HIV POSITIVI

Author: Marchesi, I, Bargellini, A, Stancanelli, G, Scaltriti, S, Moro, M, Pignato, S, Coniglio, MARIA ANNA, Giammanco, G, RIBERA DALCAL, G, Pennino, F, and Borella, P.
Subjects: anticorpi anti-Legionella, soggetti sieropositivi per HIV, legionellosi, fattori di rischio
Published: 2005

21. Is there a professional risk of Legionnaires’ disease? Results of a multicentric serological study

Author: Borella, Paola, Mazzini, Elisa, Bargellini, Annalisa, Montagna, M. T., Tatò, D., Napoli, C., Pignato, S., Giammanco, G., Coniglio, M. A., Stancanelli, G., Scaltriti, Stefania, Lopalco, L., Zotti, C. M., Giacomuzzi, M., Gentile, M., Triassi, M., Ribera D’Alcalà, G., and Pennino, F.
Subjects: Europe, Legionella infections, surveillance
Published: 2005

22. Sporadic Isolation of Sabin-Like Polioviruses and High-Level Detection of Non-Polio Enteroviruses during Sewage Surveillance in Seven Italian Cities, after Several Years of Inactivated Poliovirus Vaccination

Author: Battistone, A., primary, Buttinelli, G., additional, Fiore, S., additional, Amato, C., additional, Bonomo, P., additional, Patti, A. M., additional, Vulcano, A., additional, Barbi, M., additional, Binda, S., additional, Pellegrinelli, L., additional, Tanzi, M. L., additional, Affanni, P., additional, Castiglia, P., additional, Germinario, C., additional, Mercurio, P., additional, Cicala, A., additional, Triassi, M., additional, Pennino, F., additional, and Fiore, L., additional
Published: 2014
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23. The rapid spread of SARS-COV-2 Omicron variant in Italy reflected early through wastewater surveillance

Author: La Rosa, G., Iaconelli, M., Veneri, C., Mancini, P., Bonanno Ferraro, G., Brandtner, D., Lucentini, L., Bonadonna, L., Rossi, M., Grigioni, M., Suffredini, E., Giuseppe, Bucciarelli, Paolo, Torlontano, Giuseppe, Michele La Bianca, Rosa Anna Cifarelli, Achille, Palma, Giovanna La Vecchia, Giuseppe, Lauria, Rosanna, Brienza, Patrizia, Montenegro, Angelo, D'Argenzio, Luigi, Cossentino, Renato, Olivares, Antonio, Pizzolante, Giovanna, Fusco, Alessandra, Tosco, Amalia, Porta, Francesca, Pennino, Triassi, Maria, Paola, Angelini, Laura De Lellis, Daniele, Nasci, Giovanni, Alborali, Nicoletta, Formenti, Flavia, Guarneri, Nadia, Fontani, Giulia, Nani, Franca, Palumbo, Gianluca, Borlone, Marco, Guercio, Lisa, Gentili, Marika, Mariuz, Gabriella, Trani, Anna, Pariani, Carla, Ancona, Doriana Antonella Giorgi, Irene, Ferrante, Monica, Monfrinotti, Silvia, Riosa, Valeria, Capparuccini, Maria Teresa Scicluna, Antonella, Mariaconcetta, Arizzi, Giancarlo, Cecchini, Claudio, Ottaviano, Elena, Nicosia, Elena, Grasselli, Giorgia, Allaria, Alberto, Izzotti, Stefano, Rosatto, Emanuela, Ammoni, Danilo, Cereda, Marina Nadia Losio, Barbara, Bertasi, Andrea, Aliscioni, Desdemona, Oliva, Sara, Castiglioni, Silvia, Schiarea, Ettore, Zuccato, Manuela, Antonelli, Arianna, Azzellino, Francesca, Malpei, Andrea, Turolla, Sandro, Binda, Pellegrinelli, Laura, Valeria, Primache, Clementina, Cocuzza, Andrea, Franzetti, Giorgio, Bertanza, Maria Luisa Callegari, Luigi, Bolognini, Fabio, Filippetti, Marta, Paniccia, Francesca, Ciuti, Sara, Briscolini, Silvia, Magi, Michele, Colitti, Carmen, Montanaro, Giuseppe, Aprea, Maria Grazia Cerroni, Bartolomeo, Griglio, Renza, Berruti, Mauro, Cravero, Angela, Costa, Manila, Bianchi, Lucia, Decastelli, Angelo, Romano, Fabio, Zuccon, Elisabetta, Carraro, Cristina, Pignata, Silvia, Bonetta, Giuseppe Di Vittorio, Onofrio, Mongelli, Osvalda De Giglio, Francesca, Apollonio, Francesco, Triggiano, Maria Teresa Montagna, Nicola, Ungaro, Mario, Palermo, Carmelo Massimo Maida, Walter, Mazzucco, Simona De Grazia, Giovanni, Giammanco, Giuseppa, Purpari, Margherita, Ferrante, Antonella, Agodi, Martina, Barchitta, Piergiuseppe, Cala’, Carducci, Annalaura, Verani, Marco, Federigi, Ileana, Giulia, Lauretani, Sara, Muzio, Matteo, Ramazzotti, Alberto, Antonelli, Enrica, Ricci, Giovanni, Santoro, Ermanno, Federici, Maya, Petricciuolo, Sofia, Barigelli, Mauro, Ruffier, Francesca, Borney, Eric, Grange, Florida, Damasco, Francesca, Russo, Gisella, Pitter, Vanessa, Groppi, Franco, Rigoli, Marco, Zampini, Tatjana, Baldovin, Irene, Amoruso, Elena, Mengon, Maria, Cadonna, Mattia, Postinghel, Francesco, Pizzo, Alessandra, Schiavuzzi, Francesca, Cutrupi, Paola, Foladori, Serena, Manara, Lorella, Zago, Alberta, Stenico, Anna-Maria, Prast., La Rosa, G, Iaconelli, M, Veneri, C, Mancini, P, Bonanno Ferraro, G, Brandtner, D, Lucentini, L, Bonadonna, L, Rossi, M, Grigioni, M, Suffredini, E, Bucciarelli, G, Torlontano, P, Aprea, G, La Bianca, M, Cifarelli, R, Palma, A, La Vecchia, G, Lauria, G, Brienza, R, Montenegro, P, D'Argenzio, A, Cossentino, L, Olivares, R, Pizzolante, A, Fusco, G, Tosco, A, Porta, A, Pennino, F, Maria, T, Angelini, P, De Lellis, L, Nasci, D, Alborali, G, Formenti, N, Guarneri, F, Fontani, N, Nani, G, Palumbo, F, Borlone, G, Guercio, M, Gentili, L, Mariuz, M, Trani, G, Pariani, A, Ancona, C, Giorgi, D, Ferrante, I, Monfrinotti, M, Riosa, S, Capparuccini, V, Scicluna, M, Cersini, A, Arizzi, M, Cecchini, G, Ottaviano, C, Nicosia, E, Grasselli, E, Allaria, G, Izzotti, A, Rosatto, S, Ammoni, E, Cereda, D, Losio, M, Bertasi, B, Aliscioni, A, Oliva, D, Castiglioni, S, Schiarea, S, Zuccato, E, Antonelli, M, Azzellino, A, Malpei, F, Turolla, A, Binda, S, Laura, P, Primache, V, Cocuzza, C, Franzetti, A, Bertanza, G, Callegari, M, Bolognini, L, Filippetti, F, Paniccia', M, Ciuti, F, Briscolini, S, Magi, S, Colitti, M, Montanaro, C, Cerroni, M, Griglio, B, Berruti, R, Cravero, M, Costa, A, Bianchi, M, Decastelli, L, Romano, A, Zuccon, F, Carraro, E, Pignata, C, Bonetta, S, Di Vittorio, G, Mongelli, O, De Giglio, O, Apollonio, F, Triggiano, F, Montagna, M, Ungaro, N, Palermo, M, Maida, C, Mazzucco, W, De Grazia, S, Giammanco, G, Purpari, G, Ferrante, M, Agodi, A, Barchitta, M, Cala', P, Carducci, A, Verani, M, Federigi, I, Lauretani, G, Muzio, S, Ramazzotti, M, Antonelli, A, Ricci, E, Santoro, G, Federici, E, Petricciuolo, M, Barigelli, S, Ruffier, M, Borney, F, Grange, E, Damasco, F, Russo, F, Pitter, G, Groppi, V, Rigoli, F, Zampini, M, Baldovin, T, Amoruso, I, Mengon, E, Cadonna, M, Postinghel, M, Pizzo, F, Schiavuzzi, A, Cutrupi, F, Foladori, P, Manara, S, Zago, L, Stenico, A, Prast, A, La Rosa G., Iaconelli M., Veneri C., Mancini P., Bonanno Ferraro G., Brandtner D., Lucentini L., Bonadonna L., Rossi M., Grigioni M., Bucciarelli G., Torlontano P., Aprea G., La Bianca M., Cifarelli R.A., Palma A., La Vecchia G., Lauria G., Brienza R., Montenegro P., D'Argenzio A., Cossentino L., Olivares R., Pizzolante A., Fusco G., Tosco A., Porta A., Pennino F., Maria T., Angelini P., De Lellis L., Nasci D., Alborali G., Formenti N., Guarneri F., Fontani N., Nani G., Palumbo F., Borlone G., Guercio M., Gentili L., Mariuz M., Trani G., Pariani A., Ancona C., Giorgi D.A., Ferrante I., Monfrinotti M., Riosa S., Capparuccini V., Scicluna M.T., Cersini A., Arizzi M., Cecchini G., Ottaviano C., Nicosia E., Grasselli E., Allaria G., Izzotti A., Rosatto S., Ammoni E., Cereda D., Losio M.N., Bertasi B., Aliscioni A., Oliva D., Castiglioni S., Schiarea S., Zuccato E., Antonelli M., Azzellino A., Malpei F., Turolla A., Binda S., Laura P., Primache V., Cocuzza C., Franzetti A., Bertanza G., Callegari M.L., Bolognini L., Filippetti F., Paniccia' M., Ciuti F., Briscolini S., Magi S., Colitti M., Montanaro C., Cerroni M.G., Griglio B., Berruti R., Cravero M., Costa A., Bianchi M., Decastelli L., Romano A., Zuccon F., Carraro E., Pignata C., Bonetta S., Di Vittorio G., Mongelli O., De Giglio O., Apollonio F., Triggiano F., Montagna M.T., Ungaro N., Palermo M., Maida C.M., Mazzucco W., De Grazia S., Giammanco G., Purpari G., Ferrante M., Agodi A., Barchitta M., Cala' P., Carducci A., Verani M., Federigi I., Lauretani G., Muzio S., Ramazzotti M., Antonelli A., Ricci E., Santoro G., Federici E., Petricciuolo M., Barigelli S., Ruffier M., Borney F., Grange E., Damasco F., Russo F., Pitter G., Groppi V., Rigoli F., Zampini M., Baldovin T., Amoruso I., Mengon E., Cadonna M., Postinghel M., Pizzo F., Schiavuzzi A., Cutrupi F., Foladori P., Manara S., Zago L., Stenico A., Prast A.-M., Suffredini E., and Triassi, M
Subjects: Omicron, RT-qPCR, SARS-CoV-2, Sewage, Variant, Wastewater-based epidemiology, Wastewater-Based Epidemiological Monitoring, Environmental Engineering, COVID-19, Wastewater, Pollution, Humans, RNA, Viral, Waste Water, SARS-Cov2, Environmental Chemistry, RNA, Viral, wastewater based epidemiology, Waste Management and Disposal, Human, Omicron, RT-qPCR, SARS-CoV-2, Sewage, Variant, Wastewater-based epidemiology
Abstract: The SARS-CoV-2 Omicron variant emerged in South Africa in November 2021, and has later been identified worldwide, raising serious concerns. A real-time RT-PCR assay was designed for the rapid screening of the Omicron variant, targeting characteristic mutations of the spike gene. The assay was used to test 737 sewage samples collected throughout Italy (19/21 Regions) between 11 November and 25 December 2021, with the aim of assessing the spread of the Omicron variant in the country. Positive samples were also tested with a real-time RT-PCR developed by the European Commission, Joint Research Centre (JRC), and through nested RT-PCR followed by Sanger sequencing. Overall, 115 samples tested positive for Omicron SARS-CoV-2 variant. The first occurrence was detected on 7 December, in Veneto, North Italy. Later on, the variant spread extremely fast in three weeks, with prevalence of positive wastewater samples rising from 1.0% (1/104 samples) in the week 5-11 December, to 17.5% (25/143 samples) in the week 12-18, to 65.9% (89/135 samples) in the week 19-25, in line with the increase in cases of infection with the Omicron variant observed during December in Italy. Similarly, the number of Regions/Autonomous Provinces in which the variant was detected increased from one in the first week, to 11 in the second, and to 17 in the last one. The presence of the Omicron variant was confirmed by the JRC real-time RT-PCR in 79.1% (91/115) of the positive samples, and by Sanger sequencing in 66% (64/97) of PCR amplicons. In conclusion, we designed an RT-qPCR assay capable to detect the Omicron variant, which can be successfully used for the purpose of wastewater-based epidemiology. We also described the history of the introduction and diffusion of the Omicron variant in the Italian population and territory, confirming the effectiveness of sewage monitoring as a powerful surveillance tool.
Published: 2022

24. Predicting needlestick and sharps injuries in nursing students: Development of the SNNIP scale

Author: Milko Zanini, Christian Napoli, Alessia Manca, Leandro Gentile, Leila Fabiani, Elena Righi, Tiziana Traini, Marzia Montesano, Emanuela Santoro, Roberta Magnano San Lio, Gianluca Catania, Francesca Moretti, A Zerbetto, Mark Hayter, Beatrice Casini, C Genovese, I. Torre, Loredana Sasso, Giuseppe Calamusa, Ilaria Barberis, Nicoletta Dasso, Giovanni Battista Orsi, Cristina Arrigoni, Annamaria Bagnasco, Stefania Berdini, Anna Maria Iannicelli, Alberto Carli, Alborz Rahmani, Roger Watson, Tiziana Benedetti, Barbara Bascapè, Silvia D'Eugenio, Alberto Borraccino, Adoriano Santarelli, Raffaele Squeri, Martina Barchitta, Marco Verani, Antonio Perre, Simona Mascipinto, Mariana Sao Miguel Morgado, Lucia Palandri, Smeralda D'Amato, Maria Teresa Montagna, Giuliana Favara, Licia Veronesi, Alfredo Montecucco, Matteo Riccò, Maria Valeria Torregrossa, E Bertamino, Antonella Agodi, Vincenza La Fauci, Annalisa Bargellini, Arda Sulaj, Alberto Firenze, Ida Mura, Roberto Novati, Nicola Magnavita, Reparata Rosa Di Prinzio, Francesca Maria Bersi, Tatjana Baldovin, Sandro Ortolani, Carla Maria Zotti, Rita Fiorentini, Roberta Oriani, Marcello Mario D’Errico, Francesca Pennino, Ada Bianco, Andrea Maugeri, Anna Rita Giuliani, Giovanni Sotgiu, Paola Ferri, Valeria Teti, Edoardo Tartaglia, A Rossini, Angelo Baggiani, Guglielmo Dini, Sonia Zacconi, Daniela Schiavone, Leandra Giudice, Cesira Pasquarella, Sara Dalla Torre, Giovanni Boccia, Maria Chiara Ottino, Maurizio Mercuri, Paolo Durando, Stefano Tardivo, Emanuela Massa, Elisabetta Carraro, Deborah Traversi, Bagnasco A., Zanini M., Catania G., Watson R., Hayter M., Dasso N., Dini G., Agodi A., Pasquarella C., Zotti C.M., Durando P., Sasso L., Barchitta M., Maugeri A., Favara G., San Lio R.M., Rossini A., Squeri R., Genovese C., D'Amato S., La Fauci V., Tardivo S., Moretti F., Carli A., Casini B., Baggiani A., Verani M., Rita Giuliani A., Fabiani L., D'Eugenio S., Boccia G., Santoro E., Battista Orsi G., Napoli C., Montesano M., Berdini S., Bertamino E., Perre A., Zerbetto A., D'Errico M., Ortolani S., Mercuri M., Traini T., Santarelli A., Fiorentini R., Benedetti T., Montagna M., Mascipinto S., Torre I., Pennino F., Schiavone D., Maria Iannicelli A., Tartaglia E., Veronesi L., Palandri L., Miguel Morgado M.S., Giudice L., Arrigoni C., Gentile L., Bascape B., Mura I., Sotgiu G., Barberis I., Maria Bersi F., Manca A., Massa E., Montecucco A., Rahmani A., Zacconi S., Ricco M., Magnavita N., Di Prinzio R.R., Torregrossa M.V., Calamusa G., Firenze A., Bargellini A., Ferri P., Righi E., Carraro E., Borraccino A., Traversi D., Ottino M.C., Baldovin T., Torre S.D., Sulaj A., Bianco A., Teti V., Novati R., Oriani R., Bagnasco, A., Zanini, M., Catania, G., Watson, R., Hayter, M., Dasso, N., Dini, G., Agodi, A., Pasquarella, C., Zotti, C. M., Durando, P., Sasso, L., Barchitta, M., Maugeri, A., Favara, G., San Lio, R. M., Rossini, A., Squeri, R., Genovese, C., D'Amato, S., La Fauci, V., Tardivo, S., Moretti, F., Carli, A., Casini, B., Baggiani, A., Verani, M., Rita Giuliani, A., Fabiani, L., D'Eugenio, S., Boccia, G., Santoro, E., Battista Orsi, G., Napoli, C., Montesano, M., Berdini, S., Bertamino, E., Perre, A., Zerbetto, A., D'Errico, M., Ortolani, S., Mercuri, M., Traini, T., Santarelli, A., Fiorentini, R., Benedetti, T., Montagna, M., Mascipinto, S., Torre, I., Pennino, F., Schiavone, D., Maria Iannicelli, A., Tartaglia, E., Veronesi, L., Palandri, L., Miguel Morgado, M. S., Giudice, L., Arrigoni, C., Gentile, L., Bascape, B., Mura, I., Sotgiu, G., Barberis, I., Maria Bersi, F., Manca, A., Massa, E., Montecucco, A., Rahmani, A., Zacconi, S., Ricco, M., Magnavita, N., Di Prinzio, R. R., Torregrossa, M. V., Calamusa, G., Firenze, A., Bargellini, A., Ferri, P., Righi, E., Carraro, E., Borraccino, A., Traversi, D., Ottino, M. C., Baldovin, T., Torre, S. D., Sulaj, A., Bianco, A., Teti, V., Novati, R., and Oriani, R.
Subjects: cross-sectional, knowledge, Psychometrics, Factor structure, nursing student, Settore MED/44 - MEDICINA DEL LAVORO, Nursing, prevention, Surveys and Questionnaires, Content validity, needlestick, Medicine, Health belief model, Humans, sharps injurie, Psychometric testing, Needlestick Injuries, General Nursing, Research Articles, nursing students, lcsh:RT1-120, validation, lcsh:Nursing, business.industry, Injury epidemiology, questionnaire, sharps injuries, Discriminant validity, Exploratory factor analysis, Cross-Sectional Studies, Scale (social sciences), Students, Nursing, cross‐sectional, business, Health Belief Model, Research Article
Abstract: © 2020 The Authors. Nursing Open published by John Wiley & Sons Ltd. Aim: To develop an instrument to investigate knowledge and predictive factors of needlestick and sharps injuries (NSIs) in nursing students during clinical placements. Design: Instrument development and cross-sectional study for psychometric testing. Methods: A self-administered instrument including demographic data, injury epidemiology and predictive factors of NSIs was developed between October 2018–January 2019. Content validity was assessed by a panel of experts. The instrument's factor structure and discriminant validity were explored using principal components analysis. The STROBE guidelines were followed. Results: Evidence of content validity was found (S-CVI 0.75; I-CVI 0.50–1.00). A three-factor structure was shown by exploratory factor analysis. Of the 238 participants, 39% had been injured at least once, of which 67.3% in the second year. Higher perceptions of “personal exposure” (4.06, SD 3.78) were reported by third-year students. Higher scores for “perceived benefits” of preventive behaviours (13.6, SD 1.46) were reported by second-year students.
Published: 2020

25. Hospital discharges-based search of acute flaccid paralysis cases 2007-2016 in Italy and comparison with the National Surveillance System for monitoring the risk of polio reintroduction

Author: Stefanelli, Paola, Bellino, Stefania, Fiore, Stefano, Fontana, Stefano, Amato, Concetta, Buttinelli, Gabriele, Ansaldi, Filippo, Binda, Sandro, Pellegrinelli, Laura, Bonaccorsi, Guglielmo, Lorini, Chiara, Brusaferro, Silvio, Camilloni, Barbara, Capannolo, Benita, Mancini, Cristiana, Carraro, Valter, Castiglia, Paolo, Arghittu, Antonella, D'Errico, Marcello Mario, De Stefano, Carlo, Foca, Alfredo, CinziaGerminario, Larocca, Angela, Giammanco, Giovanni M, De Grazia, Simona, Grasso, Guido Maria, DanielaLombardi, Russo, Francesca, Napoletano, Giuseppina, Zanella, Francesca, Spertini, Silvia, Veronesi, Licia, Affanni, Paola, Triassi, Maria, Pennino, Francesca, Vairo, Francesco, Stefanelli, P., Bellino, S., Fiore, S., Fontana, S., Amato, C., Buttinelli, G., Ansaldi, F., Binda, S., Pellegrinelli, L., Bonaccorsi, G., Lorini, C., Brusaferro, S., Camilloni, B., Capannolo, B., Mancini, C., Carraro, V., Castiglia, P., Arghittu, A., D'Errico, M. M., De Stefano, C., Foca, A., Germinario, C., Larocca, A., Giammanco, G. M., De Grazia, S., Grasso, G. M., Lombardi, D., Russo, F., Napoletano, G., Zanella, F., Spertini, S., Veronesi, L., Affanni, P., Triassi, M., Pennino, F., Vairo, F., Stefanelli P., Bellino S., Fiore S., Fontana S., Amato C., Buttinelli G., Ansaldi F., Binda S., Pellegrinelli L., Bonaccorsi G., Lorini C., Brusaferro S., Camilloni B., Capannolo B., Mancini C., Carraro V., Castiglia P., Arghittu A., D'errico M.M., De Stefano C., Foca A., Germinario C., Larocca A., Giammanco G., De Grazia S., Grasso G.M., Lombardi D., Russo F., Napoletano G., Zanella F., Spertini S., Veronesi L., Affanni P., Triassi M., Pennino F., and Vairo F.
Subjects: Male, Settore MED/07 - Microbiologia E Microbiologia Clinica, Pediatrics, ERADICATION, Acute flaccid paralysi, 0302 clinical medicine, WORLDWIDE, Epidemiology, Paralysis, Medicine, 030212 general & internal medicine, Child, Public, Environmental & Occupational Health, 0303 health sciences, Polio, lcsh:Public aspects of medicine, Hospital Records, Acute flaccid paralysis, Patient Discharge, Poliomyelitis, Italy, Child, Preschool, Population Surveillance, Female, Diagnosis code, medicine.symptom, Hospital discharge record, Life Sciences & Biomedicine, Encephalitis, Research Article, Human, medicine.medical_specialty, Adolescent, Myelitis, 03 medical and health sciences, Poliomyelitis eradication, Hospital discharge records, Hospital Record, Humans, National surveillance system, Preschool, Science & Technology, 030306 microbiology, business.industry, Public Health, Environmental and Occupational Health, Infant, lcsh:RA1-1270, medicine.disease, Paralysi, Poliomyeliti, business
Abstract: Background Acute flaccid paralysis (AFP) surveillance has been adopted globally as a key strategy for monitoring the progress of the polio eradication initiative. Hereby, to evaluate the completeness of the ascertainment of AFP cases in Italy, a hospital-discharges based search was carried out. Methods AFP cases occurring between 2007 and 2016 among children under 15 years of age were searched in the Italian Hospital Discharge Records (HDR) database using specific ICD-9-CM diagnostic codes. AFP cases identified between 2015 and 2016 were then compared with those notified to the National Surveillance System (NSS). Results Over a 10-year period, 4163 hospital discharges with diagnosis of AFP were reported in Italy. Among these, 956 (23.0%) were acute infective polyneuritis, 1803 (43.3%) myopathy, and 1408 (33.8%) encephalitis, myelitis and encephalomyelitis. During the study period, a decreasing trend was observed for all diagnoses and overall the annual incidence rate (IR) declined from 5.5 to 4.5 per 100,000 children. Comparing NSS with HDR data in 2015–2016, we found a remarkable underreporting, being AFP cases from NSS only 14% of those recorded in HDR. In particular, the acute infective polyneuritis cases reported to NSS accounted for 42.6% of those detected in HDR, while only 0.9% of myopathy cases and 13.1% of encephalitis/myelitis/encephalomyelitis cases have been notified to NSS. The highest AFP IRs per 100,000 children calculated on HDR data were identified in Liguria (17.4), Sicily (5.7), and Veneto (5.1) Regions; regarding the AFP notified to the NSS, 11 out of 21 Regions failed to reach the number of expected cases (based on 1/100,000 rate), and the highest discrepancies were observed in the Northern Regions. Overall, the national AFP rate was equal to 0.6, therefore did not reach the target value. Conclusions AFP surveillance data are the final measure of a country’s progress towards polio eradication. The historical data obtained by the HDR have been useful to assess the completeness of the notification data and to identify the Regions with a low AFP ascertainment rate in order to improve the national surveillance system.
Published: 2019

26. Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery

Author: Francesca Pennino, Roberta Lanzillo, Primo Sergianni, Marcello Moccia, Raffaele Palladino, Guido Corbisiero, Vincenzo Brescia Morra, Antonio Capacchione, Giacomo Lus, Andrea Tajani, Adriano Vercellone, Maria Triassi, Rosa Acampora, Elisabetta Signoriello, Moccia, M., Tajani, Andrea, Acampora, R., Signoriello, E., Corbisiero, G., Vercellone, A., Sergianni, Primo, Pennino, F., Lanzillo, R., Palladino, R., Capacchione, A., Morra, V. B., Lus, G., Triassi, M., Moccia, M, Tajani, A, Acampora, R, Signoriello, E, Corbisiero, G, Vercellone, A, Sergianni, P, Pennino, F, Lanzillo, R, Palladino, R, Capacchione, A, Brescia Morra, V, and Lus, G
Subjects: Male, European People, Economics, Health Care Providers, Organizational model, Social Sciences, Geographical locations, Diagnostic Radiology, 0302 clinical medicine, Mathematical and Statistical Techniques, Multidisciplinary approach, Health care, Medicine and Health Sciences, Ethnicities, 030212 general & internal medicine, Allied Health Care Professionals, Multidisciplinary, Radiology and Imaging, Statistics, Neurodegenerative Diseases, Health Care Costs, Health Services, Middle Aged, Magnetic Resonance Imaging, Italian People, Medication possession ratio, Europe, Treatment Outcome, Italy, Neurology, Physical Sciences, Medicine, Regression Analysis, Female, Research Article, medicine.medical_specialty, Multiple Sclerosis, General Science & Technology, Imaging Techniques, Science, Immunology, Linear Regression Analysis, Research and Analysis Methods, Medication Adherence, Autoimmune Diseases, 03 medical and health sciences, Health Economics, Healthcare delivery, Diagnostic Medicine, medicine, Humans, Immunologic Factors, European Union, Statistical Methods, Retrospective Studies, Service (business), business.industry, Multiple sclerosis, Biology and Life Sciences, Patient Acceptance of Health Care, medicine.disease, Demyelinating Disorders, Health Care, Emergency medicine, People and Places, Linear Models, Clinical Immunology, Population Groupings, Clinical Medicine, business, Delivery of Health Care, 030217 neurology & neurosurgery, Resource utilization, Mathematics
Abstract: BackgroundMultiple sclerosis (MS) requires multidisciplinary management. We evaluated differences in healthcare resource utilization and costs between Federico II and Vanvitelli MS Centres of Naples (Italy), representative of centralised (i.e., MS Care Unit) and local service-based models of multidisciplinary care, respectively.MethodsWe included MS patients continuously seen at the same local healthcare services and MS Centre (Federico II = 187; Vanvitelli = 90) from 2015 to 2017. Healthcare resources for MS treatment and management were collected and costs were calculated. Adherence was estimated as the rate of medication possession ratio (MPR) during 3-years of follow-up. Mixed-effect linear regression models were used to estimate differences in all outcomes between Federico II and Vanvitelli.ResultsPatients at Federico II had more consultations within the MS centre (pDiscussionHealthcare services were more complete (and expensive) at the Federico II centralised MS Care Unit, compared with the Vanvitelli local service-based organizational model. Future research should evaluate whether better integration between MS Centres and local services can lead to improved MS management and lower costs.
Published: 2019

27. Attitudes towards compulsory vaccination in Italy: Results from the NAVIDAD multicentre study

Author: A. Miduri, F Quattrocolo, Francesca Pennino, F. Di Donna, E Olivero, Azzurra Massimi, Maria Rosaria Gualano, C de Waure, Fabrizio Stracci, Ilaria Loperto, P Di Giovanni, Nicola Nante, Antonio Giuliani, Marina Marranzano, Emilia Prospero, LG Sisti, C. Signorelli, Giuseppe Michele Masanotti, Silvana Castaldi, G Voglino, M. Golfera, Roberta Siliquini, Raffaele Squeri, Fabrizio Bert, P Rossello, M P Fantini, M. M. D'Errico, P. Greco, A. Stefanati, Annalisa Rosso, C Genovese, Davide Gori, G Di Martino, E. Buttinelli, G. Zappalà, Gualano, M. R., Bert, F., Voglino, G., Buttinelli, E., D'Errico, M. M., De Waure, C., Di Giovanni, P., Fantini, M. P., Giuliani, A. R., Marranzano, M., Masanotti, G., Massimi, A., Nante, N., Pennino, F., Squeri, R., Stefanati, A., Signorelli, C., Siliquini, R., Castaldi, S., Di Donna, F., Di Martino, G., Genovese, C., Golfera, M., Gori, D., Greco, P., Loperto, I., Miduri, A., Olivero, E., Prospero, E., Quattrocolo, F., Rossello, P., Rosso, A., Sisti, L. G., Stracci, F., Zappalà, G., Gualano, Mr, Bert, F, Voglino, G, Buttinelli, E, D'Errico, Mm, De Waure, C, Di Giovanni, P, Fantini, Mp, Giuliani, Ar, Marranzano, M, Masanotti, G, Massimi, A, Nante, N, Pennino, F, Squeri, R, Stefanati, A, Signorelli, C, Siliquini, R, Gualano, M R, D'Errico, M M, Fantini, M P, and Giuliani, A R
Subjects: Health Knowledge, Attitudes, Practice, Multivariate analysis, Cross-sectional study, Immunology and Microbiology (all), Attitudes, Italy, Mandatory vaccination, Multicentre survey, Pregnancy, Vaccine hesitancy, Molecular Medicine, Veterinary (all), Public Health, Environmental and Occupational Health, Infectious Diseases, Mandatory Programs, Socioeconomic Factor, Heterogeneous-Nuclear Ribonucleoproteins, Health personnel, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Multivariate Analysi, Practice, Immunization Program, Health Knowledge, Mandatory Program, Vaccination, Adolescent, Adult, Cross-Sectional Studies, Female, Health Personnel, Humans, Multivariate Analysis, Pregnant Women, Socioeconomic Factors, Immunization Programs, Public Health, Human, medicine.medical_specialty, Socio-culturale, 03 medical and health sciences, 030225 pediatrics, Socioeconomic status, Cross-Sectional Studie, Mandatory vaccination, Vaccine hesitancy, Pregnancy, Multicentre survey, Italy, General Veterinary, General Immunology and Microbiology, Health professionals, business.industry, Environmental and Occupational Health, Attitude, Family medicine, Heterogeneous-Nuclear Ribonucleoprotein, Healthcare service, business
Abstract: Background: Vaccine hesitancy is a considerable issue in European countries and leads to low coverage rates. After a long debate, Italy has made vaccination mandatory for admission to its schools.Methods: In the NAVIDAD study (a cross-sectional multicentre study), a 63-item questionnaire was administered to 1820 pregnant women from 15 Italian cities. The questionnaire assessed the interviewee's opinion on mandatory vaccines, as well as their socioeconomic status, sources of information about vaccines, confidence in the Italian National Healthcare Service (NHS), and intention to vaccinate their newborn.Results: Information sources play a key role in determining the opinion on restoration of mandatory vaccines; in particular, women who obtained information from anti-vaccination movements are less likely to accept the vaccines (OR: 0.35, 95% CI: 0.21-0.58, p < 0.001). Women who had confidence in healthcare professional information agreed more on mandatory vaccination than did the other women (OR: 2.66, 95% CI: 1.62-4.36, p < 0.001); those who perceived that healthcare professionals have economic interest in child immunization and who declared that healthcare providers inform only on vaccinations benefits not on risks were less likely to agree on compulsory vaccination (OR: 0.66, CI 95%: 0.46-0.96, p = 0.03; OR: 0.66, CI 95%: 0.46-0.95, p = 0.03, respectively).Conclusion: Information sources and confidence towards health professionals are the main determinants of acceptance of mandatory vaccine restoration. To increase the acceptability of the restoration and reduce vaccine hesitancy, these aspects need to be strengthened.
Published: 2018

28. Wastewater surveillance of SARS-CoV-2 variants in October-November 2022 in Italy: detection of XBB.1, BA.2.75 and rapid spread of the BQ.1 lineage

Author: G. La Rosa, D. Brandtner, G. Bonanno Ferraro, C. Veneri, P. Mancini, M. Iaconelli, L. Lucentini, C. Del Giudice, L. Orlandi, E. Suffredini, Achille Palma, Adelaide Calabria, Agnese Carnevali, Albano Nehludoff, Alberta Stenico, Alberto Izzotti, Alessandra Barca, Alessandra Tosco, Amalia Porta, Annalisa Lombardi, Antonia Voli, Andrea Franzetti, Angela Ciccaglione, Angela Costa, Angelo D’Argenzio, Angelo Romano, Anna Pariani, Annalaura Carducci, Annalisa Grucci, Anna-Maria Prast, Antonella Agodi, Antonella Cersini, Antonella Giorgi, Barbara Bertasi, Bartolomeo Griglio, Carla Ancona, Carmelo Massimo Maida, Carmen Montanaro, Chiara Filizzolo, Claudio Ottaviano, Clementina Cocuzza, Cristina Pignata, Daniele Nasci, Danilo Cereda, Desdemona Oliva, Doriana Antonella Giorgi, Edoardo Malacaria, Elena Grasselli, Elena Nicosia, Elisabetta Carraro, Emanuela Ammoni, Eric Grange, Ermanno Federici, Fabio Filippetti, Fabio Tramuto, Flavia Guarneri, Flavia Serio, Florida Damasco, Franca Palumbo, Francesca Apollonio, Francesca Cutrupi, Francesca Gucciardi, Francesca Pennino, Francesca Russo, Francesco Triggiano, Franco Rigoli, Gabriele Pietrella, Gabriella Trani, Gian Maria Rossolini, Giorgia Bulotta, Giovanna Fusco, Giovanna La Vecchia, Giovanni Alborali, Giovanni Giammanco, Giovanni Santoro, Gisella Pitter, Giuseppa Purpari, Giuseppe Aprea, Giuseppe Di Vittorio, Giuseppe Folino, Giuseppe Lauria, Ileana Federigi, Irene Amoruso, Irene Ferrante, Irene Tomesani, Laura De Lellis, Laura Pellegrinelli, Lea Demetz, Lisa Gentili, Lisa Richiardi, Lorella Zago, Lorena Masieri, Lucia Decastelli, Luigi Bolognini, Luigi Cossentino, Manila Bianchi, Marco Verani, Marco Zampini, Margherita Ferrante, Maria Cadonna, Maria Teresa Montagna, Maria Teresa Scicluna, Mariaconcetta Arizzi, Marika Mariuz, Mario Palermo, Marta Bellisomi, Marta Paniccià, Martina Barchitta, Matteo Ramazzotti, Mattia Postinghel, Maurizio Viscardi, Mauro Ruffier, Maya Petricciuolo, Michele La Bianca, Michele Colitti, Monica Monfrinotti, Nadia Fontani, Nicoletta Formenti, Onofrio Mongelli, Osvalda De Giglio, Paola Angelini, Paola Foladori, Paolo Torlontano, Piergiuseppe Calà, Rosa Anna Cifarelli, Sandro Binda, Sara Briscolini, Sara Castiglioni, Silvia Bonetta, Silvia Magi, Silvia Scattolini, Silvia Schiarea, Simona De Grazia, Stefano Rosatto, Tatjana Baldovin, Valeria Primache, Vanessa Groppi, Vicdalia Aniela Acciari, Walter Mazzucco, La Rosa, G, Brandtner, D, Bonanno Ferraro, G, Veneri, C, Mancini, P, Iaconelli, M, Lucentini, L, Del Giudice, C, Orlandi, L, Suffredini, E, Cocuzza, C, Franzetti, A, La Rosa, G., Brandtner, D., Bonanno Ferraro, G., Veneri, C., Mancini, P., Iaconelli, M., Lucentini, L., Del Giudice, C., Orlandi, L., Suffredini, E., Pennino, F., Lombardi, A., Maida, CM, Mazzucco, W, and Tramuto, F
Subjects: BA2.75, Environmental Engineering, Surveillance, MED/42 - IGIENE GENERALE E APPLICATA, Omicron, SARS-CoV-2, BQ.1, Wastewater, XBB.1, BIO/19 - MICROBIOLOGIA GENERALE, Pollution, MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, BA2.75, BQ.1, Omicron, SARS-CoV-2, Surveillance, Wastewater, XBB.1, Environmental Chemistry, Waste Management and Disposal
Abstract: This study adds insight regarding the occurrence and spread of SARS-CoV-2 Variants of Concern (VOCs) and Var-iants of Interest (VOIs) in Italy in October and November 2022, by testing urban wastewater collected through-out the country. A total of 332 wastewater samples were collected from 20 Italian Regions/Autonomous Provinces (APs) within the framework of national SARS-CoV-2 environmental surveillance. Of these, 164 were collected in the first week of October and 168 in the first week of November. A similar to 1600 bp fragment of the spike protein was sequenced by Sanger (for individual samples) and long-read nanopore sequencing (for pooled Region/AP samples).In October, mutations characteristic of Omicron BA.4/BA.5 were detected in the vast majority (91 %) of the samples amplified by Sanger sequencing. A fraction of these sequences (9 %) also displayed the R346T mutation. Despite the low prevalence documented in clinical cases at the time of sampling, amino acid substitutions characteristic of sublineages BQ.1 or BQ.1.1 were detected in 5 % of sequenced samples from four Regions/APs. A significantly higher variability of sequences and variants was documented in November 2022, when the rate of se-quences harbouring mutations of lineages BQ.1 and BQ1.1 increased to 43 %, and the number of Regions/APs positive for the new Omicron subvariant more than tripled (n = 13) compared to October. Moreover, an increase in the number of sequences with the mutation package BA.4/BA.5 + R346T (18 %), as well as the detection of variants never observed before in wastewater in Italy, such as BA.2.75 and XBB.1 (the latter in a Region where no clinical cases asso-ciated with this variant had ever been documented) was recorded.The results suggest that, as predicted by the ECDC, BQ.1/BQ.1.1 is rapidly becoming dominant in late 2022. Environ-mental surveillance proves to be a powerful tool for tracking the spread of SARS-CoV-2 variants/subvariants in the population.
Published: 2023

29. Job Satisfaction: Knowledge, Attitudes, and Practices Analysis in a Well-Educated Population

Author: Paolo Montuori, Michele Sorrentino, Pasquale Sarnacchiaro, Fabiana Di Duca, Alfonso Nardo, Bartolomeo Ferrante, Daniela D’Angelo, Salvatore Di Sarno, Francesca Pennino, Armando Masucci, Maria Triassi, Antonio Nardone, Montuori, P., Sorrentino, M., Sarnacchiaro, P., Di Duca, F., Nardo, A., Ferrante, B., D'Angelo, D., Di Sarno, S., Pennino, F., Masucci, A., Triassi, M., and Nardone, A.
Subjects: Adult, Health Knowledge, Attitudes, Practice, knowledge, Attitude of Health Personnel, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Personnel Turnover, job satisfaction, attitude, practice, cross-sectional survey, Surveys and Questionnaires, Humans, Child
Abstract: Job satisfaction has a huge impact on overall life quality involving social relationships, family connection and perceived health status, affecting job performances, work absenteeism and job turnover. Over the past decades, the attention towards it has grown constantly. The aim of this study is to analyze simultaneously knowledge, attitudes, and practices toward job satisfaction in a general population in a large metropolitan area. The data acquired from 1043 questionnaires—administered to subjects with an average age of 35.24 years—revealed that only 30% is satisfied by his job. Moreover, among all the tested sample, 12% receive, or often receive intimidation by their superior, and 23% wake up unhappy to go to work. Marital status and having children seem to be an important factor that negatively influences job satisfaction through worst behaviours. The multiple linear regression analysis shows how knowledge is negatively correlated to practices; although this correlation is not present in a simple linear regression showing a mediation role of attitudes in forming practices. On the contrary, attitudes, correlated both to knowledge and practices, greatly affect perceived satisfaction, leading us to target our proposed intervention toward mindfulness and to improve welfare regulation towards couples with children.
Published: 2022

30. Air microbial contamination in dental clinics: Comparison between active and passive methods

Author: Licia, Veronesi, Maria Eugenia, Colucci, Christian, Napoli, Paolo, Castiglia, Giorgio, Liguori, Ida, Torre, Elena, Righi, Patrizia, Farruggia, Marina, Tesauro, Maria Teresa, Montagna, Francesca, Gallè, Maria Dolores, Masia, Valeria, Di Onofrio, Giuseppina, Caggiano, Carola, Tinteri, Manuela, Panico, Francesca, Pennino, Lucia, Cannova, Cesira, Pasquarella, Veronesi, L., Colucci, M. E., Napoli, C., Castiglia, P., Liguori, G., Torre, I., Righi, E., Farruggia, P., Tesauro, M., Montagna, M. T., Galle, F., Masia, M. D., Di Onofrio, V., Caggiano, G., Tinteri, C., Panico, M., Pennino, F., Cannova, L., and Pasquarella, C.
Subjects: Active sampling, air, Dental Clinics, Air, Air Microbiology, Colony Count, Microbial, dental clinic, microbial contamination, air, active sampling, passive sampling, correlation, Microbial contamination, Correlation, Short Papers, Passive sampling, Dental clinic, Correlation of Data, dental clinic, microbial contamination, air, active sampling, passive sampling, correlation, active sampling, Environmental Monitoring
Abstract: The aim of this study was to evaluate the correlation between the microbial air contamination values obtained by active sampling (colony-forming units per cubic metre, CFU/m3) and by passive sampling (Index of microbial air contamination, IMA) and to calculate the corresponding equations. Air sampling was performed in ten dental clinics (DC), before (T0), during (T1) and after (T2) the clinical activity, for five consecutive days, once a month for a period of three months, for a total of 450 air samplings. The correlation was evaluated using the Spearman test, and a p value below 0.05 was considered statistically significant. A statistically significant correlation was found considering both the results obtained from the total observations and from the single sampling times, T0, T1 and T2. Different correlation patterns were observed stratifying by DC. Both methods were able to evaluate the microbial air quality and highlight critical situations; therefore, both can be used with this aim. However, in particular during the activity, passive sampling resulted more sensitive, and for its simplicity, economy and standardization by IMA, as suggested by several authors, can be suggested for routine monitoring.
Published: 2020

31. Molecular Characterization of Coxsackievirus B5 Isolates from Sewage, Italy 2016–2017

Author: Gabriele Buttinelli, Concetta Amato, Paolo Castiglia, Stefano Fiore, Paola Stefanelli, Licia Veronesi, Simona De Grazia, Antonella Cicala, Angela Maria Vittoria Larocca, Andrea Cossu, Francesca Pennino, Silvia Spertini, Sabine Gamper, Giovanni M. Giammanco, Roberta Zoni, Stefano Fontana, Angelo Siragusa, Maria Triassi, Cinzia Germinario, Fontana, S., Fiore, S., Buttinelli, G., Amato, C., Veronesi, L., Zoni, R., Triassi, M., Pennino, F., Giammanco, G. M., De Grazia, S., Cicala, A., Siragusa, Danilo, Gamper, S., Spertini, S., Castiglia, P., Cossu, A., Germinario, C., Larocca, A. M. V., Stefanelli, P., Fontana, Stefano, Fiore, Stefano, Buttinelli, Gabriele, Amato, Concetta, Veronesi, Licia, Zoni, Roberta, Triassi, Maria, Pennino, Francesca, Giammanco, Giovanni Maurizio, De Grazia, Simona, Cicala, Antonella, Siragusa, Angelo, Gamper, Sabine, Spertini, Silvia, Castiglia, Paolo, Cossu, Andrea, Germinario, Cinzia, Larocca, Angela Maria Vittoria, and Stefanelli, Paola
Subjects: 0301 basic medicine, Settore MED/07 - Microbiologia E Microbiologia Clinica, Epidemiology, Viral protein, Health, Toxicology and Mutagenesis, viruses, 030106 microbiology, Sewage, 010501 environmental sciences, Biology, Coxsackievirus, medicine.disease_cause, Brief Communication, 01 natural sciences, 03 medical and health sciences, Viral Proteins, Phylogenetic analysi, Non-polio enteroviruse, Phylogenetics, Virology, medicine, Phylogeny, 0105 earth and related environmental sciences, Polioviruse, Phylogenetic analysis, CV-B5, Phylogenetic tree, business.industry, virus diseases, Non-polio enteroviruses, biology.organism_classification, Enterovirus B, Human, Italy, GenBank, Polioviruses, Coxsackieviru, business, Food Science, Environmental Monitoring
Abstract: Hereby, the partial Viral Protein 1 sequences of Coxsackievirus B5 (CV-B5) from sewage samples, collected in Italy from 2016 to 2017, were compared with those available in GenBank from clinical samples. Phylogenetic analysis highlighted: (I) the predominant circulation of CV-B5 genogroup B in Italy, and (II) the presence of two new sub-genogroups.
Published: 2019

32. A competitive cell-permeable peptide impairs Nme-1 (NDPK-A) and Prune-1 interaction: therapeutic applications in cancer

Author: Massimo Zollo, Francesco Paolo Pennino, Veronica Ferrucci, Roberto Siciliano, Fatemeh Asadzadeh, Ferrucci, V., Pennino, F. P., Siciliano, R., Asadzadeh, F., and Zollo, M
Subjects: 0301 basic medicine, Prune-1, Nme-1, cell motility, mimetic peptides, metastases, Cell signaling, Peptide, Computational biology, Cell-Penetrating Peptides, Pathology and Forensic Medicine, Protein–protein interaction, 03 medical and health sciences, 0302 clinical medicine, Neuroblastoma, Neoplasms, medicine, Humans, Cell permeable peptide, Phosphorylation, Molecular Biology, chemistry.chemical_classification, Chemistry, Cancer, Cell Biology, NM23 Nucleoside Diphosphate Kinases, medicine.disease, Phosphoric Monoester Hydrolases, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Tumor Suppressor Protein p53, Carrier Proteins
Abstract: The understanding of protein–protein interactions is crucial in order to generate a second level of functional genomic analysis in human disease. Within a cellular microenvironment, protein–protein interactions generate new functions that can be defined by single or multiple modes of protein interactions. We outline here the clinical importance of targeting of the Nme-1 (NDPK-A)–Prune-1 protein complex in cancer, where an imbalance in the formation of this protein–protein complex can result in inhibition of tumor progression. We discuss here recent functional data using a small synthetic competitive cell-permeable peptide (CPP) that has shown therapeutic efficacy for impairing formation of the Nme-1–Prune-1 protein complex in mouse preclinical xenograft tumor models (e.g., breast, prostate, colon, and neuroblastoma). We thus believe that further discoveries in the near future related to the identification of new protein–protein interactions will have great impact on the development of new therapeutic strategies against various cancers.
Published: 2017

33. Consumer awareness and knowledge regarding use of non-steroidal anti-inflammatory drugs (NSAIDs) in a metropolitan area.

Author: Montuori P, Shojaeian SZ, Pennino F, D'Angelo D, Sorrentino M, Di Sarno S, Nubi R, Nardo A, and Triassi M
Abstract: Background: Non-steroidal anti-inflammatory drugs (NSAIDs) have well-known adverse effects, and numerous studies have shown inappropriate behaviors regarding their use. The primary aim of this study was to analyze the knowledge, attitudes, and behaviors regarding the use of NSAIDs simultaneously in one of the largest and most populated areas of Italy, Naples., Methods: From 2021 December 14th to 2022 January 4th, a cross-sectional survey study was conducted among community centers, working places, and universities using a snowball sampling method. For inclusion in the study, the participants were required to be at least 18 years old and residents in the metropolitan area of Naples. Three multiple linear regression analysis (MLRA) models were developed by including variables that could potentially be associated with the following outcomes of interest: knowledge (Model I), attitudes (Model II), and behavior (Model III) regarding the use of NSAIDs., Results: Data were acquired from 1,012 questionnaires administered to subjects evenly divided by gender with an average age of 36.8 years and revealed that only 7.9% of the participants self-admittedly did not take NSAIDs, while approximately half the participants (50%) admitted to occasionally using them. The results showed a statistically significant correlation between attitudes regarding the appropriate use of NSAIDs and less knowledge. The regression analyses indicated that behaviors regarding the appropriate use of NSAIDs were statistically significant in younger respondents, non-smokers, and those without children. These interesting results showed that behaviors regarding the appropriate use of NSAIDs were significantly higher among respondents with less knowledge and more positive attitudes., Conclusion: According to the collected data and statistical analysis results, it is possible to identify factors that can greatly affect inappropriate behaviors regarding the use of NSAIDs and establish targeted prevention programs., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Montuori, Shojaeian, Pennino, D’Angelo, Sorrentino, Di Sarno, Nubi, Nardo and Triassi.)
Published: 2024
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34. Investigating Awareness Regarding Travel-Related Infectious Disease Prevention in a Metropolitan Area.

Author: Pennino F, Fiorilla C, Sorrentino M, Armonia U, Parisi A, Mirizzi PD, Di Lillo M, De Silva O, Montuori P, Triassi M, and Nardone A
Abstract: The rise in international travel has led to an increase in travel-related infectious diseases. It is predicted that by 2030, the number of international travelers will reach 1.8 billion, with over 250 million people affected globally. This issue also has an economic impact, as the eradication of travel-related infectious diseases leads to a loss of USD 12 billion in tourism. To understand the association between demographic variables and knowledge, attitude, and behaviors related to travel-related infectious diseases, a cross-sectional survey-based study was conducted among 1191 individuals in the metropolitan city of Naples, Italy. Multiple linear regression was performed over three models. The results revealed that knowledge about travel-related infectious diseases was positively associated with age, female gender, non-smoking habits, being single, and higher education attainment. The attitude towards travel-related infectious diseases was positively associated with being female, non-smoking habits, being single, higher education attainment, and a higher level of knowledge. A statistically significant association was observed between behaviors and non-smoking habits and between higher levels of knowledge and attitudes. To address this issue, public health programs could be implemented to improve behaviors in the general population. Overall, this study provides valuable information about the determinants of knowledge, attitude, and behaviors related to travel-related infectious diseases in the general population.
Published: 2023
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35. Understanding Factors Contributing to Vaccine Hesitancy in a Large Metropolitan Area.

Author: Montuori P, Gentile I, Fiorilla C, Sorrentino M, Schiavone B, Fattore V, Coscetta F, Riccardi A, Villani A, Trama U, Pennino F, Triassi M, and Nardone A
Abstract: Vaccine hesitancy has become a major global concern, leading to a significant decrease in the vaccination rate, with the World Health Organization recognizing it as one of the top ten threats to public health. Moreover, the health cost generated is evaluated to be 27 billion dollars per year in the US alone. To investigate the association between demographic variables and knowledge, attitudes, and behaviours related to vaccination, a survey-based cross-sectional study was conducted with 1163 individuals. Three models were used to perform a multiple linear regression analysis. In Model I, knowledge about vaccinations was found to be associated with smoking habits, education, and marital status. In Model II, attitudes towards vaccinations were significantly associated with sex, smoking habits, education, marital status, and knowledge. In Model III, behaviours related to vaccination were associated with sex, smoking habits, having children, knowledge, and attitudes. One potential solution to improve behaviours related to vaccinations in the general population is to implement specific public health programs, which can be a cost-effective intervention. This study provides valuable insights into the determinants of knowledge, attitudes, and behaviours related to vaccinations in the general population.
Published: 2023
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36. Insights from a Cross-Sectional Study on Knowledge, Attitudes and Behaviors Concerning Antibiotic Use in a Large Metropolitan Area: Implications for Public Health and Policy Interventions.

Author: Pennino F, Maccauro ML, Sorrentino M, Gioia M, Riello S, Messineo G, Di Rosa C, Montuori P, Triassi M, and Nardone A
Abstract: The overuse and inappropriate use of antibiotics pose a grave threat to public health, contributing significantly to the accelerated development of antimicrobial resistance (AMR) and increased rates of morbidity and mortality, making it a leading cause of death globally. To examine the relationship between demographic variables and knowledge, attitudes, and behaviors concerning antibiotic use, a survey-based cross-sectional study was conducted involving 1158 individuals. The questionnaire included two sections: in the first section, participants' socio-demographic characteristics were analyzed; the second investigated knowledge, attitudes, and behaviors concerning antibiotics utilization using a total of 36 questions. Descriptive statistics were used, and then a multiple linear regression analysis (MLRA) using three models was carried out. In Model I, knowledge about antibiotics exhibited correlations with smoking habits and educational attainment. In Model II, attitudes were significantly associated with gender, smoking habits, age, education, relationship status, and knowledge. In Model III, behaviors related to antibiotics were correlated with educational attainment, having children, knowledge, and attitudes. Implementing tailored public health programs could be a cost-effective intervention to enhance behaviors associated with antibiotic use in the general population. This study offers valuable insights into the determinants of knowledge, attitudes, and behaviors regarding antibiotics in the general population.
Published: 2023
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37. SARS-CoV-2 RNA in Wastewater and Bivalve Mollusk Samples of Campania, Southern Italy.

Author: Lombardi A, Voli A, Mancusi A, Girardi S, Proroga YTR, Pierri B, Olivares R, Cossentino L, Suffredini E, La Rosa G, Fusco G, Pizzolante A, Porta A, Campiglia P, Torre I, Pennino F, and Tosco A
Subjects: Humans, Animals, Wastewater, RNA, Viral genetics, SARS-CoV-2 genetics, Italy epidemiology, COVID-19 epidemiology, Bivalvia
Abstract: SARS-CoV-2 can be detected in the feces of infected people, consequently in wastewater, and in bivalve mollusks, that are able to accumulate viruses due to their ability to filter large amounts of water. This study aimed to monitor SARS-CoV-2 RNA presence in 168 raw wastewater samples collected from six wastewater treatment plants (WWTPs) and 57 mollusk samples obtained from eight harvesting sites in Campania, Italy. The monitoring period spanned from October 2021 to April 2022, and the results were compared and correlated with the epidemiological situation. In sewage, the ORF1b region of SARS-CoV-2 was detected using RT-qPCR, while in mollusks, three targets-RdRp, ORF1b, and E-were identified via RT-dPCR. Results showed a 92.3% rate of positive wastewater samples with increased genomic copies (g.c.)/(day*inhabitant) in December-January and March-April 2022. In the entire observation period, 54.4% of mollusks tested positive for at least one SARS-CoV-2 target, and the rate of positive samples showed a trend similar to that of the wastewater samples. The lower SARS-CoV-2 positivity rate in bivalve mollusks compared to sewages is a direct consequence of the seawater dilution effect. Our data confirm that both sample types can be used as sentinels to detect SARS-CoV-2 in the environment and suggest their potential use in obtaining complementary information on SARS-CoV-2.
Published: 2023
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38. Risk Influence of Some Environmental and Behavioral Factors on Air Contamination in the Operating Room: An Experimental Study.

Author: Albertini P, Mainardi P, Bagattini M, Lombardi A, Riccio P, Ragosta M, Pennino F, Bruzzese D, and Triassi M
Subjects: Humans, Dust, Bacterial Load, Drug Contamination, Operating Rooms, Air Pollution
Abstract: Air contamination in operating rooms (ORs) depends on the conditions of the room and on activities therein performed. Methodologies of air quality assessment in ORs are often inadequately described in the scientific literature, and the time required for a change in status in air quality is never taken into account. The purpose of this study was to determine the influence of the state and the presence of human operators on air quality by implementing a precise measurement protocol that also took into account the time required for changes in the room to affect air pollution. As the main indicators of air pollution, bacterial load and concentration of airborne dust were measured. The results showed that: the use of surgical masks by operators in the OR did not significantly affect bacterial load within a distance of 2 m; keeping OR doors open did not induce a significant increase in bacterial load and of 5 μm particles while 10 μm particles concentration was positively affected; and air pollution measured with open doors was not significantly different from that due to the presence of two staff members, whether or not they were wearing masks. The results clarified the role of some factors on air pollution in ORs.
Published: 2023
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39. Understanding Hearing Health: A Cross-Sectional Study of Determinants in a Metropolitan Area.

Author: Pennino F, Di Lillo M, Sorrentino M, Fiorilla C, Parisi A, Mirizzi PD, De Simone B, Montuori P, Triassi M, and Nardone A
Abstract: Hearing health prevention has emerged as a significant public health concern worldwide. With nearly two and a half billion people experiencing some degree of hearing loss, and around seven hundred million requiring medical intervention, the impact on global health is substantial. The economic burden is equally substantial, with estimated health costs reaching 980 billion dollars in the United States alone. To shed light on this issue, we conducted a survey-based cross-sectional study involving 1150 individuals. Utilizing multiple linear regression across three models, we aimed to explore the association between demographic variables and knowledge, attitude, and behaviors related to hearing health. In Model I, we observed a correlation between knowledge and several factors, including age, smoking habits, marital status, and education. In Model II, attitudes were found to associate with non-smoking habits, education, and knowledge. Model III revealed a statistically significant correlation between behaviors and age, gender, parenthood, knowledge, and attitudes. These findings emphasize the importance of targeted public health programs aimed at improving behaviors among the general population. Such interventions can be both effective and relatively inexpensive. By addressing these determinants, we can enhance overall hearing health in the community. Our study contributes valuable information about the knowledge, attitudes, and behaviors related to hearing health in the general population. Understanding these factors is crucial in developing evidence-based strategies to promote hearing health and prevent hearing loss effectively. As we continue to work towards better hearing health, the findings from this study can serve as a cornerstone for informed decision-making and successful intervention implementation.
Published: 2023
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40. Environmental Monitoring of Legionella in Hospitals in the Campania Region: A 5-Year Study.

Author: Lombardi A, Borriello T, De Rosa E, Di Duca F, Sorrentino M, Torre I, Montuori P, Trama U, and Pennino F
Subjects: Humans, Chlorine analysis, Water Supply, Hospitals, Environmental Monitoring, Water analysis, Water Microbiology, Legionella, Legionella pneumophila
Abstract: Legionella is a pathogen that colonizes soils, freshwater, and building water systems. People who are most affected are those with immunodeficiencies, so it is necessary to monitor its presence in hospitals. The purpose of this study was to evaluate the presence of Legionella in water samples collected from hospitals in the Campania region, Southern Italy. A total of 3365 water samples were collected from January 2018 to December 2022 twice a year in hospital wards from taps and showers, tank bottoms, and air-treatment units. Microbiological analysis was conducted in accordance with the UNI EN ISO 11731:2017, and the correlations between the presence of Legionella and water temperature and residual chlorine were investigated. In total, 708 samples (21.0%) tested positive. The most represented species was L. pneumophila 2-14 (70.9%). The serogroups isolated were 1 (27.7%), 6 (24.5%), 8 (23.3%), 3 (18.9%), 5 (3.1%), and 10 (1.1%). Non- pneumophila Legionella spp. represented 1.4% of the total. Regarding temperature, the majority of Legionella positive samples were found in the temperature range of 26.0-40.9 °C. An influence of residual chlorine on the presence of the bacterium was observed, confirming that chlorine disinfection is effective for controlling contamination. The positivity for serogroups other than serogroup 1 suggested the need to continue environmental monitoring of Legionella and to focus on the clinical diagnosis of other serogroups.
Published: 2023
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41. Determinants Analysis Regarding Household Chemical Indoor Pollution.

Author: Montuori P, Gioia M, Sorrentino M, Di Duca F, Pennino F, Messineo G, Maccauro ML, Riello S, Trama U, Triassi M, and Nardone A
Abstract: Indoor household pollution is not yet sufficiently studied in the general population. Over 4 million people die prematurely every year due to air pollution in households. This study aimed to propose quantitative data research through the administration of a KAP (Knowledge, Attitudes, and Practices) Survey Questionnaire. This cross-sectional study administered questionnaires to adults from the metropolitan city of Naples (Italy). Three Multiple Linear Regression Analyses (MLRA) were developed, including Knowledge, Attitudes, and Behavior regarding household chemical air pollution and the related risks. One thousand six hundred seventy subjects received a questionnaire to be filled out and collected anonymously. The mean age of the sample was 44.68 years, ranging from 21-78 years. Most of the people interviewed (76.13%) had good attitudes toward house cleaning, and 56.69% stated paying attention to cleaning products. Results of the regression analysis indicated that positive attitudes were significantly higher among subjects who graduated, with older age, male and non-smokers, but they were correlated with lower knowledge. In conclusion, a behavioral and attitudinal program targeted those with knowledge, such as younger subjects with high educational levels, but do not engage in correct practices towards household indoor chemical pollution.
Published: 2023
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42. Assessment on Practicing Correct Body Posture and Determinant Analyses in a Large Population of a Metropolitan Area.

Author: Montuori P, Cennamo LM, Sorrentino M, Pennino F, Ferrante B, Nardo A, Mazzei G, Grasso S, Salomone M, Trama U, Triassi M, and Nardone A
Abstract: An incorrect posture can generate stress of the spine and can be the cause of musculoskeletal disorders. Considering the extensive use of the computer, which worsens posture disorders, among workers, is important to analyze the phenomenon in order to reduce his impact on industry. The aim of this study is to assess determinants regarding posture in a large population of a metropolitan area. A total of 1177 questionnaires was analyzed. The majority of sample showed good knowledge and attitude regarding correct posture; most of the sample, 70.4% was aware of the definition of posture and 68.7% feel that not enough attention is paid at posture at workplace. Despite the good predisposition, only 2.8% of the sample consult a specialist for posture. The multiple linear regression analysis shows that those who have higher knowledge and best attitudes will consequently have good behaviors in maintaining a correct posture. Furthermore, age and education resulted main drivers of correct posture in any model considered. The results enlighten the necessity of conducting further studies to analyze attitudes of the general population and suggest improving educational and training programs to the enrichment of knowledge and to correct posture behaviors.
Published: 2023
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43. Job Satisfaction: Knowledge, Attitudes, and Practices Analysis in a Well-Educated Population.

Author: Montuori P, Sorrentino M, Sarnacchiaro P, Di Duca F, Nardo A, Ferrante B, D'Angelo D, Di Sarno S, Pennino F, Masucci A, Triassi M, and Nardone A
Subjects: Child, Humans, Adult, Personnel Turnover, Attitude of Health Personnel, Surveys and Questionnaires, Health Knowledge, Attitudes, Practice, Job Satisfaction
Abstract: Job satisfaction has a huge impact on overall life quality involving social relationships, family connection and perceived health status, affecting job performances, work absenteeism and job turnover. Over the past decades, the attention towards it has grown constantly. The aim of this study is to analyze simultaneously knowledge, attitudes, and practices toward job satisfaction in a general population in a large metropolitan area. The data acquired from 1043 questionnaires-administered to subjects with an average age of 35.24 years-revealed that only 30% is satisfied by his job. Moreover, among all the tested sample, 12% receive, or often receive intimidation by their superior, and 23% wake up unhappy to go to work. Marital status and having children seem to be an important factor that negatively influences job satisfaction through worst behaviours. The multiple linear regression analysis shows how knowledge is negatively correlated to practices; although this correlation is not present in a simple linear regression showing a mediation role of attitudes in forming practices. On the contrary, attitudes, correlated both to knowledge and practices, greatly affect perceived satisfaction, leading us to target our proposed intervention toward mindfulness and to improve welfare regulation towards couples with children.
Published: 2022
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44. COVID-19: opinions and behavior of Italian general population during the first epidemic phase.

Author: Genovese C, La Fauci V, Di Pietro A, Trimarchi G, Odone A, Casuccio A, Costantino C, Restivo V, Fantini M, Gori D, Azara A, Deiana G, Castaldi S, Righi E, Palandri L, Panciroli G, Bianco A, Licata F, Cosentino S, Mistretta A, Marranzano M, Ragusa R, Gabutti G, Stefanati A, Prato R, Fortunato F, Martinelli D, Icardi G, Panatto D, Amicizia D, Fabiani L, Moretti A, Di Risio D, Siliquini R, Voglino G, Bert F, Lorini C, Bonaccorsi G, Torre I, Pennino F, Pavia M, Di Giuseppe G, Paolantonio A, Villari P, Marzuillo C, Messina G, Rivieri C, Nante N, Majori S, Tardivo S, Moretti F, D'Amato S, Mazzitelli F, Giunta I, Lo Giudice D, Pantò G, Signorelli C, and Squeri R
Subjects: Attitude, Female, Humans, Male, Public Health, SARS-CoV-2, COVID-19, Epidemics
Abstract: Background and Aim: On January 9, 2020, the World Health Organization (WHO) declared that Chinese health authorities had identified a new coronavirus strain never before isolated in humans, the 2019-nCoV later redefined SARS-CoV-2, that still today represent a public health problem. The present survey started on 10 February 2020 with the aim of a) assessing the risk perception in healthcare workers and young students, following the evolution of attitudes, perception and knowledge over time, b) provide useful information to the general population during survey., Results: A study sample consisting of 4116 Italian individuals of both sexes was enrolled. High levels of risk perception, low perception of self-efficacy and low levels of knowledge scores (24.55 ± 5.76 SD) were obtained indicating the need for continuous population monitoring as well as further communication strategies carried out at institution levels., Conclusion: The results of the present study could help public health authorities in carrying out informative campaigns for general population and could be an important tool in evaluating public knowledge and misperceptions during the management of the COVID-19. (www.actabiomedica.it).
Published: 2022
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45. Prevalence of SARS-CoV-2 Antibodies in Multiple Sclerosis: The Hidden Part of the Iceberg.

Author: Capasso N, Palladino R, Montella E, Pennino F, Lanzillo R, Carotenuto A, Petracca M, Iodice R, Iovino A, Aruta F, Pastore V, Buonomo AR, Zappulo E, Gentile I, Triassi M, Brescia Morra V, and Moccia M
Abstract: Background: We compared the prevalence of SARS-CoV-2 IgG/IgM in multiple sclerosis (MS), low-risk, and high-risk populations and explored possible clinical correlates., Methods: In this cross-sectional study, we recruited MS patients, low-risk (university staff from non-clinical departments), and high-risk individuals (healthcare staff from COVID-19 wards) from 11 May to 15 June 2020. We used lateral flow immunoassay to detect SARS-CoV-2 IgG and IgM. We used t-test, Fisher's exact test, chi square test, or McNemar's test, as appropriate, to evaluate between-group differences., Results: We recruited 310 MS patients (42.3 ± 12.4 years; females 67.1%), 862 low-risk individuals (42.9 ± 13.3 years; females 47.8%), and 235 high-risk individuals (39.4 ± 10.9 years; females 54.5%). The prevalence of SARS-CoV-2 IgG/IgM in MS patients (n = 9, 2.9%) was significantly lower than in the high-risk population (n = 25, 10.6%) ( p < 0.001), and similar to the low-risk population (n = 11, 1.3%) ( p = 0.057); these results were also confirmed after random matching by age and sex (1:1:1). No significant differences were found in demographic, clinical, treatment, and laboratory features. Among MS patients positive to SARS-CoV-2 IgG/IgM (n = 9), only two patients retrospectively reported mild and short-lasting COVID-19 symptoms., Conclusions: MS patients have similar risk of SARS-CoV-2 infection to the general population, and can be asymptomatic from COVID-19, also if using treatments with systemic immunosuppression.
Published: 2020
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46. Predicting needlestick and sharps injuries in nursing students: Development of the SNNIP scale.

Author: Bagnasco A, Zanini M, Catania G, Watson R, Hayter M, Dasso N, Dini G, Agodi A, Pasquarella C, Zotti CM, Durando P, Sasso L, Barchitta M, Maugeri A, Favara G, Lio RMS, Rossini A, Squeri R, Genovese C, D'Amato S, La Fauci V, Tardivo S, Moretti F, Carli A, Casini B, Baggiani A, Verani M, Giuliani AR, Fabiani L, D'Eugenio S, Boccia G, Santoro E, Orsi GB, Napoli C, Montesano M, Berdini S, Bertamino E, Perre A, Zerbetto A, D'Errico M, Ortolani S, Mercuri M, Traini T, Santarelli A, Fiorentini R, Benedetti T, Montagna MT, Mascipinto S, Torre I, Pennino F, Schiavone D, Iannicelli AM, Tartaglia E, Veronesi L, Palandri L, Morgado MSM, Giudice L, Arrigoni C, Gentile L, Bascapè B, Mura I, Sotgiu G, Barberis I, Bersi FM, Manca A, Massa E, Montecucco A, Rahmani A, Zacconi S, Riccò M, Magnavita N, Di Prinzio RR, Torregrossa MV, Calamusa G, Firenze A, Bargellini A, Ferri P, Righi E, Carraro E, Borraccino A, Traversi D, Ottino MC, Baldovin T, Torre SD, Sulaj A, Bianco A, Teti V, Novati R, and Oriani R
Subjects: Cross-Sectional Studies, Humans, Psychometrics, Surveys and Questionnaires, Needlestick Injuries epidemiology, Students, Nursing
Abstract: Aim: To develop an instrument to investigate knowledge and predictive factors of needlestick and sharps injuries (NSIs) in nursing students during clinical placements., Design: Instrument development and cross-sectional study for psychometric testing., Methods: A self-administered instrument including demographic data, injury epidemiology and predictive factors of NSIs was developed between October 2018-January 2019. Content validity was assessed by a panel of experts. The instrument's factor structure and discriminant validity were explored using principal components analysis. The STROBE guidelines were followed., Results: Evidence of content validity was found (S-CVI 0.75; I-CVI 0.50-1.00). A three-factor structure was shown by exploratory factor analysis. Of the 238 participants, 39% had been injured at least once, of which 67.3% in the second year. Higher perceptions of "personal exposure" (4.06, SD 3.78) were reported by third-year students. Higher scores for "perceived benefits" of preventive behaviours (13.6, SD 1.46) were reported by second-year students., Competing Interests: Roger Watson, Editor in Chief, and Mark Hayter, Editor of the Journal of Advanced Nursing, hold honorary positions at the University of Genoa where the study was conducted., (© 2020 The Authors. Nursing Open published by John Wiley & Sons Ltd.)
Published: 2020
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47. Air microbial contamination in dental clinics: comparison between active and passive methods.

Author: Veronesi L, Colucci ME, Napoli C, Castiglia P, Liguori G, Torre I, Righi E, Farruggia P, Tesauro M, Montagna MT, Gallè F, Masia MD, Di Onofrio V, Caggiano G, Tinteri C, Panico M, Pennino F, Cannova L, and Pasquarella C
Subjects: Colony Count, Microbial, Correlation of Data, Air Microbiology, Dental Clinics, Environmental Monitoring methods
Abstract: The aim of this study was to evaluate the correlation between the microbial air contamination values obtained by active sampling (colony-forming units per cubic metre, CFU/m3) and by passive sampling (Index of microbial air contamination, IMA) and to calculate the corresponding equations. Air sampling was performed in ten dental clinics (DC), before (T0), during (T1) and after (T2) the clinical activity, for five consecutive days, once a month for a period of three months, for a total of 450 air samplings. The correlation was evaluated using the Spearman test, and a p value below 0.05 was considered statistically significant. A statistically significant correlation was found considering both the results obtained from the total observations and from the single sampling times, T0, T1 and T2. Different correlation patterns were observed stratifying by DC. Both methods were able to evaluate the microbial air quality and highlight critical situations; therefore, both can be used with this aim. However, in particular during the activity, passive sampling resulted more sensitive, and for its simplicity, economy and standardization by IMA, as suggested by several authors, can be suggested for routine monitoring.
Published: 2020
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48. Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery.

Author: Moccia M, Tajani A, Acampora R, Signoriello E, Corbisiero G, Vercellone A, Sergianni P, Pennino F, Lanzillo R, Palladino R, Capacchione A, Brescia Morra V, Lus G, and Triassi M
Subjects: Delivery of Health Care organization & administration, Female, Health Care Costs, Health Services, Humans, Italy, Linear Models, Male, Medication Adherence, Middle Aged, Retrospective Studies, Treatment Outcome, Immunologic Factors economics, Immunologic Factors therapeutic use, Multiple Sclerosis drug therapy, Multiple Sclerosis economics, Patient Acceptance of Health Care statistics & numerical data
Abstract: Background: Multiple sclerosis (MS) requires multidisciplinary management. We evaluated differences in healthcare resource utilization and costs between Federico II and Vanvitelli MS Centres of Naples (Italy), representative of centralised (i.e., MS Care Unit) and local service-based models of multidisciplinary care, respectively., Methods: We included MS patients continuously seen at the same local healthcare services and MS Centre (Federico II = 187; Vanvitelli = 90) from 2015 to 2017. Healthcare resources for MS treatment and management were collected and costs were calculated. Adherence was estimated as the rate of medication possession ratio (MPR) during 3-years of follow-up. Mixed-effect linear regression models were used to estimate differences in all outcomes between Federico II and Vanvitelli., Results: Patients at Federico II had more consultations within the MS centre (p<0.001), blood tests (p<0.001), and psychological/cognitive evaluations (p = 0.040). Patients at Vanvitelli had more consultations at local services (p<0.001). Adherence was not-significantly lower at Vanvitelli (p = 0.060), compared with Federico II. Costs for MS treatment and management were 10.6% lower at Vanvitelli (12417.08±8448.32EUR) (95%CI = -19.0/-2.7%;p = 0.007), compared with Federico II (15318.57±10919.59EUR)., Discussion: Healthcare services were more complete (and expensive) at the Federico II centralised MS Care Unit, compared with the Vanvitelli local service-based organizational model. Future research should evaluate whether better integration between MS Centres and local services can lead to improved MS management and lower costs., Competing Interests: The authors have declared that no competing interests exist.
Published: 2019
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49. A Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis.

Author: Reale C, Russo F, Credendino SC, Cuomo D, De Vita G, Mallardo M, Pennino F, Porreca I, Triassi M, De Felice M, and Ambrosino C
Subjects: Animals, Carcinogenesis, Carcinogens toxicity, Cell Line, Chlorpyrifos toxicity, Female, Maternal-Fetal Exchange, Mice, Mitogen-Activated Protein Kinases metabolism, Polychlorinated Dibenzodioxins toxicity, Pregnancy, Rats, Receptors, Cell Surface genetics, Thyroid Epithelial Cells drug effects, Thyroid Epithelial Cells metabolism, Transcription Factors genetics, Tristetraprolin genetics, Gene Regulatory Networks, Thyroid Neoplasms genetics
Abstract: Epidemiological and experimental studies emphasize the link between environmental chemicals exposure and thyroid cancer. However, this association is strongly debated and the mechanisms of action of environmental thyroid carcinogens still need to be identified. The analysis of in vitro transcriptomic data developed to investigate the effects of chlorpyrifos on immortalized thyrocytes highlighted the impaired expression of genes involved in endodermal carcinogenesis. This endodermal carcinogenic gene-network (ECGN, including Zfp36l2 , Dmbt1 , Ddit4 ), was validated in cellular and mouse models of thyroid carcinogenesis, characterized by the constitutive activation of the mitogen-activated protein kinase (MAPK) pathway and in immortalized thyrocytes exposed to tetrachlorodibenzo- p -dioxin (TCDD) and chlorpyrifos (CPF). The mRNA levels of Zfp36l2 , Dmbt1 and Ddit4 were increased in models characterized by MAPK activation or following TCDD exposure, whereas they were inhibited by CPF exposure. Overall, the ECGN transcripts identify a novel gene-regulatory network associated with thyroid carcinogenesis promoted by genetic mutation or by environmental carcinogens. The latter have opposite effects on the modulation of the ECGN transcripts according to their mechanisms of action in promoting carcinogenesis. Therefore, the analyses of ECGN might be helpful in discriminating compounds that promote cellular survival associated or not to proliferation of thyrocytes.
Published: 2019
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50. Knowledge, experiences, and attitudes toward Mantoux test among medical and health professional students in Italy: a cross-sectional study.

Author: Montagna MT, Mascipinto S, Pousis C, Bianchi FP, Caggiano G, Carpagnano LF, De Giglio O, Barbuti G, Auxilia F, Destrebecq A, Castaldi S, Baldovin T, Bargellini A, Righi E, Boccia G, Santoro E, Casini B, Baggiani A, Novati R, Oriani R, Odone A, Mezzoiuso AG, Orsi GB, Napoli C, Pasquarella C, Veronesi L, Ripabelli G, Sammarco ML, Rossini A, Squeri R, Laganà P, Antonuccio GM, Genovese C, Tardivo S, Torre I, Alfano R, Pennino F, Torregrossa MV, Barchitta M, and Agodi A
Subjects: Adolescent, Adult, Cross-Sectional Studies, Female, Humans, Italy, Latent Tuberculosis diagnosis, Logistic Models, Male, Middle Aged, Statistics, Nonparametric, Students, Health Occupations statistics & numerical data, Surveys and Questionnaires, Tuberculosis, Pulmonary diagnosis, Young Adult, Attitude of Health Personnel, Health Knowledge, Attitudes, Practice, Latent Tuberculosis prevention & control, Students, Health Occupations psychology, Tuberculin Test psychology, Tuberculosis, Pulmonary prevention & control
Abstract: Background: The World Health Organization's Action Framework for tuberculosis elimination in low-tuberculosis incidence countries includes the screening for active and latent tuberculosis in selected high-risk groups, including health care workers. In this context, medical and health profession students, exposed to nosocomial tuberculosis transmission during training and clinical rotations, are target populations for tuberculosis screening. No updated data are available on tuberculosis screening practice and knowledge of medical and health profession students in Italy., Methods: Within the activities Italian Study Group on Hospital Hygiene of the Italian Society of Hygiene, Preventive Medicine and Public Health, we carried out a multicentre cross-sectional study to assess knowledge, attitude and practices on tuberculosis prevention and control among Medical, Dentistry, Nursing and other health professions' students. Students were enrolled in the study on a voluntary basis and were administered a previously piloted structured questionnaire. Logistic regression models were applied to explore knowledge on tuberculosis prevention by selected socio-demographic variables and University-based tuberculosis prevention practice., Results: Students of seventeen Universities across Italy participated in the study, and 58.2% of them received compulsory tuberculin skin test either at enrollment or while attending clinical practice. A total of 5,209 students filled the questionnaire. 37.7% were medicine and dentistry students (Group 1), 44.9% were nursing students (Group 2) and 17.4% were other health professions' students (Group 3). Age and gender had different distributions by groups, as well as knowledge and practice on tuberculin skin test. 84.4% of the study population (95% CI = 83.3-85.3) was aware of the existence of the tuberculin skin test, 74.4% (95% CI = 73.2-75.6) knew what is the first-level screening test for latent tuberculosis and only 22.5% (95% CI = 21.4-23.6) knew how to proceed after a positive tuberculin skin test result. Overall, knowledge on tuberculosis prevention was higher in Group 2 and lower Group 3, as compared to Group 1., Conclusion: In Italy, the knowledge on tuberculosis screening among University students is generally good. To reduce some of the criticalities found among the different study courses, it would be appropriate to harmonize both the regulations on tuberculosis screening practices for admission to University courses, and the educational activities on the topic of tuberculosis, to be extended to all workers involved in health care setting.
Published: 2018
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