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10. Comparative Analysis of Korean Nasal Morphology Using Cone-Beam Computed Tomography.

Author

Lee, Jeong-Hyun and Park, Jong-Tae

Subjects
NASAL anatomy, FACIAL anatomy, NASAL radiography, FACE, THREE-dimensional imaging, STRUCTURAL models, T-test (Statistics), DATA analysis, RESEARCH funding, COMPUTED tomography, SEX distribution, RHINOPLASTY, ONE-way analysis of variance, STATISTICS, COMPARATIVE studies, DATA analysis software, ANTHROPOMETRY, CONFIDENCE intervals
Abstract

Background/Objectives: Nasal morphology is a significant aspect of facial anatomy and is often used for forensic identification and aesthetic surgery. This study aims to compare nasal dimensions based on sex, facial index (FI), and nasal index (NI) using cone-beam computed tomography (CBCT) and 3D modeling. Methods: To observe differences in nasal dimensions by sex and analyze the relationships between facial shapes (FI) and nasal forms (NI), a total of 100 participants (50 males, 50 females) in their 20s were selected from Dankook University Dental Hospital. CBCT scans were performed, and 3D models were created using Mimics software (version 22.0). The measurement items included the alaria distance between (AL), the distance between N (nasion) and SN (subnasale), the distance between N (nasion) and PRN (pronasale), and the distance between SN (subnasale) and PRN (pronasale). A T-test was used for the sex-based analysis of the nasal dimensions, and the facial index- and nasal index-based nasal dimensions were analyzed using a one-way ANOVA with Scherffe's post hoc test. Additionally, all the statistical analyses were performed using SPSS software (version 23.0). Results: The results indicated that males generally have larger nasal dimensions than females. Additionally, the mesoprosopic facial type (round face) showed the largest nasal dimensions in the FI classification, while the platyrrhine nasal type (broad and short nose) exhibited the largest dimensions in the NI classification. Conclusions: This study demonstrates that the nasal size varies significantly with sex, facial shape, and nasal form. The findings can contribute to forensic identification and provide valuable data for clinical practices in facial reconstruction and nasal surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Postmortem-Derived Exosomal MicroRNA 486-5p as Potential Biomarkers for Ischemic Heart Disease Diagnosis.

Author

Kim, So-Yeon, Lee, Sookyoung, Park, Jong-Tae, Lee, Su-Jin, and Kim, Hyung-Seok

Subjects
MYOCARDIAL infarction, CORONARY disease, MYOCARDIAL ischemia, GENE expression, CORONARY artery disease
Abstract

Exosomes are nanovesicles 30–150 nm in diameter released extracellularly. Those isolated from human body fluids reflect the characteristics of their cells or tissues of origin. Exosomes carry extensive biological information from their parent cells and have significant potential as biomarkers for disease diagnosis and prognosis. However, there are limited studies utilizing exosomes in postmortem diagnostics. In this study, we extended our initial research which identified the presence and established detection methodologies for exosomes in postmortem fluids. We analyzed exosomal miRNA extracted from plasma and pericardial fluid samples of a control group (n = 13) and subjects with acute myocardial infarction (AMI; n = 24). We employed next-generation sequencing (NGS) to investigate whether this miRNA could serve as biomarkers for coronary atherosclerosis leading to acute myocardial infarction. Our analysis revealed 29 miRNAs that were differentially expressed in the AMI group compared to the control group. Among these, five miRNAs exhibited more than a twofold increase in expression across all samples from the AMI group. Specifically, miR-486-5p levels were significantly elevated in patients with high-grade (type VI or above) atherosclerotic plaques, as per the American Heart Association criteria, highlighting its potential as a predictive biomarker for coronary atherosclerosis progression. Our results indicate that postmortem-derived exosomal microRNAs can serve as potential biomarkers for various human diseases, including cardiovascular disorders. This finding has profound implications for forensic diagnostics, a field critically lacking diagnostic markers. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Isolation, Physicochemical Characterization, and Biological Properties of Inotodiol, the Potent Pharmaceutical Oxysterol from Chaga Mushroom

Author

Nguyen, Phu Cuong, primary, Nguyen, My Tuyen Thi, additional, Truong, Ba Tai, additional, Kim, Dae-Ryeol, additional, Shin, Sujin, additional, Kim, Ju-Eun, additional, Park, Kyu-Been, additional, Park, Ji-Hyun, additional, Tran, Phuong Lan, additional, Ban, So-Young, additional, Kim, Jaehan, additional, and Park, Jong-Tae, additional

Published
2023
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44. Association of Urinary Bisphenols Concentration with Asthma in Korean Adolescents: Data from the Third Korean National Environmental Health Survey

Author

Park Jong-Tae, Kwak Kyeongmin, and Baek Kiook

Subjects
medicine.medical_specialty, endocrine system, asthma, bisphenol, endocrine disruptor, Bisphenol F, Health, Toxicology and Mutagenesis, Urinary system, Lifetime prevalence, TP1-1185, Toxicology, urologic and male genital diseases, Article, Environmental health, Epidemiology, medicine, Asthma, Chemical Health and Safety, business.industry, urogenital system, Chemical technology, Confounding, Odds ratio, medicine.disease, respiratory tract diseases, business, hormones, hormone substitutes, and hormone antagonists
Abstract

The effects of bisphenol A (BPA) on asthma have been reported in various in vitro, animal, and human epidemiologic studies. However, epidemiological studies on the effects of bisphenol S (BPS) and bisphenol F (BPF), which are substitutes of BPA, on asthma are lacking. The purpose of this study was to identify the association between BPA, BPS, and BPF and asthma. An asthma-related questionnaire; urinary BPA, BPS, BPF; and the possible confounders were analyzed among 922 adolescents aged 12–17 years who participated in the Korean National Environmental Health Survey 2016. In males, urinary BPA, BPS, and BPF did not show a significant relationship with the lifetime prevalence of asthma. In females, urinary BPS was higher in the asthma group (p < 0.01). High urinary BPS showed a significant relationship with a high odds ratio (OR) of lifetime asthma prevalence in the model adjusted for possible confounders (p < 0.05). High urinary BPS was particularly associated with an increase in the OR of asthma diagnosed after the age of 60 months (p < 0.01). Urinary BPS was significantly associated with asthma diagnosis, especially after the age of 60 months, among Korean adolescent females.

Published
2021

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