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3. Niemann–Pick C1-like 1 as a Prognostic Marker in Renal Cell Carcinoma: A Retrospective Cohort Study.

Author

Kwon, Ryuk Jun, Kim, Ho Jun, Lee, Young-Shin, Lee, Hye Sun, Lee, Sang Yeoup, Park, Eun-Ju, Lee, Youngin, Lee, Sae Rom, Choi, Jung-In, Son, Soo Min, Lee, Jeong Gyu, Yi, Yu Hyeon, Tak, Young Jin, Lee, Seung-Hun, Kim, Gyu Lee, Ra, Young Jin, and Cho, Young Hye

Subjects
RENAL cell carcinoma, OVERALL survival, PROGRESSION-free survival, SURVIVAL rate, RENAL cancer
Abstract

Background: Renal cell carcinoma (RCC) is a highly aggressive malignancy accounting for the majority of kidney cancers. Despite recent advancements in therapeutic options, the prognosis for advanced-stage RCC remains poor. Niemann–Pick C1-Like 1 (NPC1L1) plays a crucial role in cholesterol absorption and has been implicated in cancer progression across various cancers. However, its expression patterns and prognostic significance in RCC remain unclear. Methods: In this study, NPC1L1 expression in normal and RCC tissues, including subtypes, was compared using TCGA, GEPIA2, and The Human Protein Atlas. Clinical correlations were assessed, and the impact of NPC1L1 on overall survival (OS) and progression-free survival (PFS) was evaluated. Gene effect scores were analyzed using the DepMap tool to determine the involvement of NPC1L1 in RCC progression. Results: NPC1L1 expression was significantly lower in RCC tissues compared to normal tissues, particularly in the clear cell RCC (ccRCC), papillary RCC (pRCC), and chromophobe RCC (chRCC) subtypes, but increased in advanced tumor stages. Higher NPC1L1 expression was associated with worse OS and PFS in RCC patients. Multivariable Cox regression confirmed NPC1L1 as an independent prognostic marker. Additionally, gene effect scores showed that NPC1L1 is essential for the survival of specific RCC cell lines. Conclusions: This study determines NPC1L1 as an independent prognostic indicator in RCC, with higher expression associated with poor survival outcomes. These findings suggest that NPC1L1 could serve as a valuable marker for identifying high-risk RCC patients. Further research is required to investigate the molecular mechanisms underlying the role of NPC1L1 in RCC progression. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Correlation between Hearing Impairment and the Triglyceride Glucose Index in Middle-Aged Female Based on a Korean National Health and Nutrition Examination Survey.

Author

Kim, Dong Oh, Lee, Youngin, Lee, Sang Yeoup, Lee, Jeong Gyu, Yi, Yu Hyeon, Cho, Young Hye, Tak, Young Jin, Park, Eun Ju, Lee, Seung Hun, Kim, Gyu Lee, Choi, Jung In, Ra, Young Jin, Lee, Sae Rom, Kwon, Ryuk Jun, Son, Soo Min, Lee, Su Min, and Lee, Jong Suk

Subjects
AUDIOMETRY, HEALTH & Nutrition Examination Survey, HORMONE therapy, HEARING disorders, MIDDLE-aged women
Abstract

Background and Objectives: This study aimed to investigate the association between insulin resistance, as measured by the triglyceride–glucose index (TyG index), and hearing impairment in middle-aged women in Korea. Materials and Methods: This cross-sectional survey utilized data from the Korea National Health and Nutrition Examination Survey (KNHANES) IV (2007–2009), specifically from the period after July 21, 2009, when hearing test results became available, and from the KNHANES V (2010–2012). This study was conducted on 5416 women aged 40 to 69 who had completed both the health examination survey and audiometric tests, excluding those with missing data on menopausal status and the use of hormone replacement therapy. Results: In the study group, the prevalence of high-frequency hearing loss according to the TyG index was significantly higher in the mild hearing loss group (OR = 1.29; 95% CI: 1.12, 1.49, p < 0.001) and the moderate hearing loss group (OR = 1.27; 95% CI: 1.09, 1.48, p = 0.002). Conversely, the prevalence of low-frequency hearing loss did not show a significant difference in either the mild hearing loss group (OR = 1.17; 95% CI: 0.99, 1.37, p = 0.065) and the moderate hearing loss group (OR = 1.13; 95% CI: 0.94, 1.35, p = 0.199) Conclusions: Since diabetes can induce hearing impairment in women, it is recommended that women with a high TyG index undergo early hearing tests [ABSTRACT FROM AUTHOR]

Published
2024
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14. Association between Sleep Duration and Presbycusis in Korean Adults: Korea National Health and Nutrition Examination Survey

Author

Kang, Min Ju, primary, Lee, Youngin, additional, Kim, Yun Jin, additional, Lee, Sang Yeoup, additional, Lee, Jeong Gyu, additional, Yi, Yu Hyeon, additional, Cho, Young Hye, additional, Tak, Young Jin, additional, Park, Eun Ju, additional, Lee, Seung Hun, additional, Kim, Gyu Lee, additional, Choi, Jung In, additional, Ra, Young Jin, additional, Lee, Sae Rom, additional, Kwon, Ryuk Jun, additional, Son, Soo Min, additional, Lee, Yea Ji, additional, and Choi, Young Eun, additional

Published
2023
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17. Association between Serum Folic Acid Levels and Asthma in the Korean Population: A Study Based on the 2016–2018 Korea National Health and Nutrition Examination Survey

Author

Kim, So Ra, primary, Park, Eun Ju, additional, Cho, Young Hye, additional, Lee, Sang Yeoup, additional, Choi, Jung-In, additional, Lee, Young-In, additional, Lee, Sae Rom, additional, Kim, Yun Jin, additional, Lee, Jeong Gyu, additional, Yi, Yu Hyeon, additional, Tak, Young Jin, additional, Lee, Seung Hun, additional, Kim, Gyu Lee, additional, and Ra, Young Jin, additional

Published
2022
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20. Association between new anthropometric parameters and arterial stiffness based on brachial-ankle pulse wave velocity

Author

Choi,Hee Seon, Cho,Young Hye, Lee,Sang Yeoup, Park,Eun Ju, Kim,Yun Jin, Lee,Jeong Gyu, Yi,Yu Hyeon, Tak,Young Jin, Hwang,Hye Rim, and Lee,Seung Hun

Subjects
anthropometric index, arterial stiffness, cardiovascular diseases, brachial-ankle pulse wave velocity, Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity], Original Research
Abstract

Hee Seon Choi,1Young Hye Cho,1Sang Yeoup Lee,1Eun Ju Park,1Yun Jin Kim,2,3Jeong Gyu Lee,2,3Yu Hyeon Yi,2,3Young Jin Tak,2,3Hye Rim Hwang,2,3Seung Hun Lee2,3 1Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 50612, South Korea; 2Department of Family Medicine, Pusan National University School of Medicine, Yangsan 626-780, South Korea; 3Department of Family Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 626-770, South KoreaCorrespondence: Young Hye ChoFamily Medicine Clinic, Obesity, Metabolism and Nutrition Center and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, South KoreaTel +82 51 240 7707Fax +82 51 240 7843Email younghey82@naver.comBackground: Obesity is an important risk factor of cardiovascular disease (CVD). Atherosclerosis can be considered an important signal of CVD. Primary physicians can reduce the risk of CVD by preventing and treating obesity. Therefore, finding a tool to diagnose the association of obesity with arteriosclerosis is important. The association between obesity parameters and arterial stiffness remains controversial. To our knowledge, no previous studies reported the relationships between multiple new anthropometric parameters (a body shape index [ABSI], body round index [BRI], and visceral adiposity index [VAI]) and brachial-ankle wave velocity (ba-PWV) as an indicator of CVD risk, especially in the Korean population.Objective: To investigate the relationships between arterial stiffness (assessed using ba-PWV) and anthropometric parameters estimated on the basis of body mass index (BMI), waist circumference (WC), ABSI, BRI, and VAI, and to identify the indicators of obesity that best represents CVD risk.Methods: A total of 2,647 adults (1,474 men and 1,173 women) were recruited for this cross-sectional study. The correlations between the anthropometric indexes (BMI, WC, ABSI, BRI, and VAI) and mean ba-PWV were analyzed. Amultivariate linear regression analysis was performed to evaluate the association between each anthropometric and the presence of arterial stiffness.Results: We investigated the relationships between the obesity parameters and ba-PWV by adjusting the covariates (age, diabetes mellitus [DM], hypertension [HTN], and smoking status) related to the mean ba-PWV. In the multivariate regression analysis, ABSI (men: β =0.066, p

Published
2019

21. Association between Near Work Time and Depression among Workers in South Korea

Author

Jeong, Na Rae, primary, Lee, Seung Hun, additional, Kim, Yun Jin, additional, Lee, Jeong Gyu, additional, Yi, Yu Hyeon, additional, Tak, Yougn Jin, additional, Hwang, Hye Rim, additional, Kim, Gyu Lee, additional, Lee, Sang Yeoub, additional, Cho, Young Hye, additional, Park, Eun Ju, additional, Lee, Young In, additional, and Choi, Jung In, additional

Published
2021
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26. Safety, Efficacy, and Patient Satisfaction with Initial Peripherally Inserted Central Catheters Compared with Usual Intravenous Access in Terminally Ill Cancer Patients: A Randomized Phase II Study

Author

Park, Eun Ju, primary, Park, Kwonoh, additional, Kim, Jae-Joon, additional, Oh, Sang-Bo, additional, Jung, Ki Sun, additional, Oh, So Yeon, additional, Hong, Yun Jeong, additional, Kim, Jin Hyeok, additional, Jang, Joo Yeon, additional, and Jeon, Ung-Bae, additional

Published
2021
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27. Diet-Regulating Microbiota and Host Immune System in Liver Disease

Author

Eom, Jung A, primary, Kwon, Goo Hyun, additional, Kim, Na Yeon, additional, Park, Eun Ju, additional, Won, Sung Min, additional, Jeong, Jin Ju, additional, Raja, Ganesan, additional, Gupta, Haripriya, additional, Asmelash Gebru, Yoseph, additional, Sharma, Satyapriya, additional, Choi, Ye Rin, additional, Kim, Hyeong Seop, additional, Yoon, Sang Jun, additional, Hyun, Ji Ye, additional, Jeong, Min Kyo, additional, Park, Hee Jin, additional, Min, Byeong Hyun, additional, Choi, Mi Ran, additional, Kim, Dong Joon, additional, and Suk, Ki Tae, additional

Published
2021
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28. Association between Time to First Cigarette and Health-Related Quality of Life of Middle-Aged Male Current Smokers: A Nationwide Representative Study in Korea

Author

Jo, Sung Eun, primary, Hwang, Hye Rim, additional, Kim, Yun Jin, additional, Lee, Sang Yeoup, additional, Lee, Jeong Gyu, additional, Yi, Yu Hyeon, additional, Cho, Young Hye, additional, Tak, Young Jin, additional, Lee, Seung Hun, additional, Park, Eun Ju, additional, and Lee, Youngin, additional

Published
2021
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29. The Risk of Osteoporosis and Osteoporotic Fracture Following the Use of Irritable Bowel Syndrome Medical Treatment: An Analysis Using the OMOP CDM Database

Author

Kim, Gyu Lee, primary, Yi, Yu Hyeon, additional, Hwang, Hye Rim, additional, Kim, Jinmi, additional, Park, Youngmin, additional, Kim, Yun Jin, additional, Lee, Jeong Gyu, additional, Tak, Young Jin, additional, Lee, Seung Hun, additional, Lee, Sang Yeoup, additional, Cho, Youn Hye, additional, Park, Eun Ju, additional, and Lee, Youngin, additional

Published
2021
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30. Association Between Weekend Catch-Up Sleep and Metabolic Syndrome with Sleep Restriction in Korean Adults: A Cross-Sectional Study Using KNHANES

Author

Son, Soo Min, Park, Eun-Ju, Cho, Young Hye, Lee, Sang Yeoup, Choi, Jung-In, Lee, Young-In, Kim, Yun Jin, Lee, Jeong Gyu, Yi, Yu Hyeon, Tak, Young Jin, Hwang, Hye Rim, Lee, Seung-Hun, Kwon, Ryuk Jun, and Kim, Choongrak

Subjects
insulin sensitivity, sleep deprivation, Targets and Therapy [Diabetes, Metabolic Syndrome and Obesity], sleep recovery, metabolic syndrome, Original Research
Abstract

Soo Min Son,1 Eun-Ju Park,1 Young Hye Cho,1 Sang Yeoup Lee,1 Jung-In Choi,1 Young-In Lee,1 Yun Jin Kim,2 Jeong Gyu Lee,2 Yu Hyeon Yi,2 Young Jin Tak,2 Hye Rim Hwang,2 Seung-Hun Lee,2 Ryuk Jun Kwon,1 Choongrak Kim3 1Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 50612, South Korea; 2Department of Family Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 626-770, South Korea; 3Department of Statistics Pusan National University, Busan 609-735, South KoreaCorrespondence: Eun-Ju ParkMedical of Family Medicine, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan 50612 Tel +82-55-360-2140Fax +82-55-360-2170Email everblue124@hanmail.netBackground: Many researchers have identified that adequate sleep duration is linked to the quality of life and metabolic diseases. Nowadays, it is hard to take enough sleep, so weekend catch-up sleep (CUS) may be an alternative option in modern society. To our knowledge, no previous studies reported the association between weekend CUS and metabolic syndrome, especially in the Korean population.Objective: We investigated the association between weekend CUS and the prevalence of metabolic syndrome in Korean adults (≥ 20 years old) with less than 6 hours of average weekday sleep.Patients and Methods: A total of 1,453 individuals were selected from the Korean National Health and Nutrition Examination Survey. Weekend CUS was divided into four categories: ≤ 0 hour, 0– 1 hour, 1– 2 hours, and ≥ 2 hours. Odds ratios (ORs) with 95% confidence intervals (CIs) were derived by univariate and multivariate logistic regression analyses.Results: Participants with weekend CUS ≥ 1 hour had decreased risk of metabolic syndrome in univariate analysis (CUS 1– 2 hours: OR: 0.413, 95% CI: 0.301– 0.568; CUS ≥ 2 hours: OR: 0.382, 95% CI 0.296– 0.493). Weekend CUS 1– 2 hours reduced the risk of metabolic syndrome in multivariate logistic regression analysis (OR: 0.552, 95% CI: 0.369– 0.823). Based on the age group analysis, weekend CUS ≥ 1 hour reduced the metabolic syndrome among those aged 20– 39 and 40– 65 (20– 39: CUS 1– 2 hours OR: 0.248, 95% CI: 0.078– 0.783, CUS ≥ 2 hours OR: 0.374, 95% CI: 0.141– 0.991; 40– 65: CUS 1– 2 hours OR: 0.507, 95% CI 0.309– 0.832 CUS ≥ 2 hours OR: 0.638, 95% CI: 0.415– 0.981).Conclusion: Weekend CUS was associated with a low risk of metabolic syndrome among Korean adults with sleep restriction.Keywords: sleep recovery, sleep deprivation, metabolic syndrome, insulin sensitivity

Published
2020

32. The Relationship of Sitting Time and Physical Activity on the Quality of Life in Elderly People

Author

Choi, Jung In, primary, Cho, Young Hye, additional, Kim, Yun Jin, additional, Lee, Sang Yeoup, additional, Lee, Jeong Gyu, additional, Yi, Yu Hyeon, additional, Tak, Young Jin, additional, Hwang, Hye Rim, additional, Lee, Seung Hun, additional, Park, Eun Ju, additional, Lee, Young In, additional, Ra, Young Jin, additional, and Lee, Su Jin, additional

Published
2021
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34. Association between Relative Handgrip Strength and Dyslipidemia in Korean Adults: Findings of the 2014–2015 Korea National Health and Nutrition Examination Survey

Author

Kim, Bo Mi, primary, Yi, Yu Hyeon, additional, Kim, Yun Jin, additional, Lee, Sang Yeoup, additional, Lee, Jeong Gyu, additional, Cho, Young Hye, additional, Tak, Young Jin, additional, Hwang, Hye Rim, additional, Lee, Seung Hun, additional, Park, Eun Ju, additional, and Lee, Youngin, additional

Published
2020
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37. Validating the Translated Version of CARS(Changes in Attitude About the Relevance of Science), Exploring Variables Related to CARS Scores, and Constructing Two Equivalent Test Sets of CARS

Author

Arif Rachmatullah, Park Eun Ju, Sangeui Lee, and Ha， Min Su

Subjects
business.industry, Computer science, Relevance (information retrieval), Artificial intelligence, computer.software_genre, business, computer, Natural language processing, Test (assessment)
Published
2017
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39. Association Between Weekend Catch-Up Sleep and Metabolic Syndrome with Sleep Restriction in Korean Adults: A Cross-Sectional Study Using KNHANES

Author

Son,Soo Min, Park,Eun-Ju, Cho,Young Hye, Lee,Sang Yeoup, Choi,Jung-In, Lee,Young-In, Kim,Yun Jin, Lee,Jeong Gyu, Yi,Yu Hyeon, Tak,Young Jin, Hwang,Hye Rim, Lee,Seung-Hun, Kwon,Ryuk Jun, Kim,Choongrak, Son,Soo Min, Park,Eun-Ju, Cho,Young Hye, Lee,Sang Yeoup, Choi,Jung-In, Lee,Young-In, Kim,Yun Jin, Lee,Jeong Gyu, Yi,Yu Hyeon, Tak,Young Jin, Hwang,Hye Rim, Lee,Seung-Hun, Kwon,Ryuk Jun, and Kim,Choongrak

Abstract

Soo Min Son,1 Eun-Ju Park,1 Young Hye Cho,1 Sang Yeoup Lee,1 Jung-In Choi,1 Young-In Lee,1 Yun Jin Kim,2 Jeong Gyu Lee,2 Yu Hyeon Yi,2 Young Jin Tak,2 Hye Rim Hwang,2 Seung-Hun Lee,2 Ryuk Jun Kwon,1 Choongrak Kim3 1Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 50612, South Korea; 2Department of Family Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 626-770, South Korea; 3Department of Statistics Pusan National University, Busan 609-735, South KoreaCorrespondence: Eun-Ju ParkMedical of Family Medicine, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan 50612 Tel +82-55-360-2140Fax +82-55-360-2170Email everblue124@hanmail.netBackground: Many researchers have identified that adequate sleep duration is linked to the quality of life and metabolic diseases. Nowadays, it is hard to take enough sleep, so weekend catch-up sleep (CUS) may be an alternative option in modern society. To our knowledge, no previous studies reported the association between weekend CUS and metabolic syndrome, especially in the Korean population.Objective: We investigated the association between weekend CUS and the prevalence of metabolic syndrome in Korean adults (≥ 20 years old) with less than 6 hours of average weekday sleep.Patients and Methods: A total of 1,453 individuals were selected from the Korean National Health and Nutrition Examination Survey. Weekend CUS was divided into four categories: ≤ 0 hour, 0– 1 hour, 1– 2 hours, and ≥ 2 hours. Odds ratios (ORs) with 95% confidence intervals (CIs) were derived by univariate and multivariate logistic regression analyses.Results: Participants with weekend CUS ≥ 1 hour had decreased risk of metabolic syndrome in univariate analysis (CUS 1– 2 hours: OR: 0.413, 95% CI: 0.301– 0.568; CUS &

Published
2020

43. Metabolic syndrome as a risk factor for high intraocular pressure: the Korea National Health and Nutrition Examination Survey 2008–2010

Author

Yi,Yu Hyeon, Cho,Young Hye, Kim,Yun Jin, Lee,Sang Yeoup, Lee,Jeong Gyu, Kong,EunHee, Cho,Byung Mann, Tak,Young Jin, Hwang,Hye Rim, Lee,Seung Hun, Park,Eun Ju, Yi,Yu Hyeon, Cho,Young Hye, Kim,Yun Jin, Lee,Sang Yeoup, Lee,Jeong Gyu, Kong,EunHee, Cho,Byung Mann, Tak,Young Jin, Hwang,Hye Rim, Lee,Seung Hun, and Park,Eun Ju

Abstract

Yu Hyeon Yi,1,2 Young Hye Cho,3 Yun Jin Kim,1,2 Sang Yeoup Lee,3 Jeong Gyu Lee,1,2 Eun Hee Kong,4 Byung Mann Cho,5 Young Jin Tak,1,2 Hye Rim Hwang,1,2 Seung Hun Lee,1,2 Eun Ju Park3 1Department of Family Medicine, Pusan National University School of Medicine, Yangsan 626-780, Korea; 2Department of Family Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan 626-770, Korea; 3Department of Family Medicine, Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626–780, Korea; 4Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea; 5Department of Preventive Medicine, Pusan National University School of Medicine, Yangsan 626-780, Korea Background: High intraocular pressure (IOP) is well established as the most significant risk factor for both the development and progression of primary open-angle glaucoma. Elevated IOP is more frequently seen in the presence of metabolic disturbances that are associated with the components of metabolic syndrome (MetS). The aim of this study was to investigate the association between ocular hypertension and MetS.Patients and methods: We examined the relationship between ocular hypertension and MetS in 17,160 Korean adults without glaucoma aged >19 years (7,368 men and 9,792 women) who participated in the 2008–2010 Korea National Health and Nutrition Examination Survey. Multivariate logistic regression analysis was used to assess the relationship between MetS and ocular hypertension, after adjusting for age, body mass index, smoking, alcohol consumption, and regular exercise.Results: The prevalence of MetS was 35.1% among males and 30.1% among females. The prevalence of ocular hypertension was 1.3% among males with MetS and 0.7% among females with MetS. Participants with MetS had a significantly higher IOP than those without MetS (P≤0.001), and each component of MetS had a differen

Published
2019

48. HMGCLL1 is a predictive biomarker for deep molecular response to imatinib therapy in chronic myeloid leukemia

Author

Park, Jong-Ho, primary, Woo, Young Min, additional, Youm, Emilia Moonkyung, additional, Hamad, Nada, additional, Won, Hong-Hee, additional, Naka, Kazuhito, additional, Park, Eun-Ju, additional, Park, June-Hee, additional, Kim, Hee-Jin, additional, Kim, Sun-Hee, additional, Kim, Hyeoung-Joon, additional, Ahn, Jae Sook, additional, Sohn, Sang Kyun, additional, Moon, Joon Ho, additional, Jung, Chul Won, additional, Park, Silvia, additional, Lipton, Jeffrey H., additional, Kimura, Shinya, additional, Kim, Jong-Won, additional, and Kim, Dennis (Dong Hwan), additional

Published
2018
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50. Histopathologic characteristics of lung adenocarcinomas with epidermal growth factor receptor mutations in the International Association for the Study of Lung Cancer/ American Thoracic Society/European Respiratory Society lung adenocarcinoma classification

Author

Shim, Hyo Sup, Lee, Da Hye, Park, Eun Ju, and Kim, Se Hoon

Subjects
Tumors -- Genetic aspects -- Analysis, Adenocarcinoma -- Genetic aspects -- Analysis, Medical records -- Analysis, Epidermal growth factor -- Analysis, Health, World Health Organization, European Respiratory Society
Abstract

* Context.--The proposed International Association for the Study of Lung Cancer/American Thoracic Society/ European Respiratory Society classification of lung adenocarcinomas has been published. Objective.--To evaluate the correlation between epidermal growth factor receptor mutations and histologic subtypes of lung adenocarcinomas according to the upcoming new classification of lung adenocarcinomas. Design.--Medical records and pathologic slides were reviewed for a total of 107 surgically resected lung adenocarcinomas. All tumors were reclassified according to the predominant histologic subtype, and comprehensive histologic subtyping with semiquantitative assessment of each of the histologic subtypes in increments of 5% was performed. Correlations with epidermal growth factor receptor status were then evaluated. Results.--Epidermal growth factor receptor mutations were found in 54 cases (50.5%). Epidermal growth factor receptor mutations were significantly associated with the micropapillary-predominant subtype (P = .02) and with the presence (any amount) of the lepidic component (P = .02). Conclusion.--The upcoming International Association for the Study of Lung Cancer/American Thoracic Society/ European Respiratory Society classification of lung adenocarcinoma is relevant in that it shows a phenotype-genotype correlation. Comprehensive histologic subtyping should be recommended because of the association of particular subtypes with epidermal growth factor receptor mutations. doi:10.5858/arpa.2010-0493-OA, Non-small cell lung cancer (NSCLC) is a major cause of cancer deaths. (1,2) Among histologic types of NSCLCs, rates of adenocarcinoma are increasing in most countries. (3) Lung adenocarcinomas are [...]

Published
2011
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