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4. Front-line liquid biopsy for early molecular assessment and treatment of hospitalized lung cancer patients

Author

Parisi, Francesca, De Luca, Giuseppa, Mosconi, Manuela, Lastraioli, Sonia, Dellepiane, Chiara, Rossi, Giovanni, Puglisi, Silvia, Bennicelli, Elisa, Barletta, Giulia, Zullo, Lodovica, Santamaria, Sara, Mora, Marco, Ballestrero, Alberto, Montecucco, Fabrizio, Bellodi, Andrea, Del Mastro, Lucia, Lambertini, Matteo, Barisione, Emanuela, Cittadini, Giuseppe, Tagliabue, Elena, Spagnolo, Francesco, Tagliamento, Marco, Coco, Simona, Dono, Mariella, and Genova, Carlo

Published
2024
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5. Diagnosis of lung cancer following emergency admission: Examining care pathways, clinical outcomes, and advanced NSCLC treatment in an Italian cancer Center

Author

Vallome, Giacomo, Cafaro, Iacopo, Bottini, Annarita, Dellepiane, Chiara, Rossi, Giovanni, Bennicelli, Elisa, Parisi, Francesca, Zullo, Lodovica, Tagliamento, Marco, Ballestrero, Alberto, Barisione, Emanuela, Grazia Piroddi, Ines Maria, Montecucco, Fabrizio, Carbone, Federico, Pronzato, Paolo, Lambertini, Matteo, Spagnolo, Francesco, Barletta, Giulia, Barcellini, Lucrezia, Ferrante, Michele, Nardin, Simone, Coco, Simona, Marconi, Silvia, Zinoli, Linda, Moscatelli, Paolo, Arboscello, Eleonora, Del Mastro, Lucia, Bellodi, Andrea, and Genova, Carlo

Published
2023
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7. Age at Tumor Diagnosis in 14,636 Canine Cases from the Pathology-Based UNIPI Animal Cancer Registry, Italy: One Size Doesn't Fit All.

Author

Fonti, Niccolò, Parisi, Francesca, Lachi, Alessio, Dhein, Elena Sophie, Guscetti, Franco, Poli, Alessandro, and Millanta, Francesca

Subjects
MAST cell tumors, FEMALE dogs, EVENT history analysis, AGE distribution, AGE differences, DOGS
Abstract

Simple Summary: Cancer is the leading cause of death in adult dogs. All dogs would benefit from early diagnosis, but there are no official guidelines for cancer screening in pets, although many different diagnostic tools for cancer detection are being studied. With our analysis of 14,636 cases, we aimed to determine the age of cancer diagnosis for dogs. Malignant tumors were diagnosed more often than benign neoplasms in older dogs. Intact females, large-sized, brachy-/dolichocephalic, and purebred dogs developed cancer at a younger age, but wide differences between breeds were noted. The earliest age at diagnosis was recorded for lymphomas and mast cell tumors. Due to the wide phenotypic and genetic variability of canines, breed-based screening schedules should be devised. Cancer is the most common cause of death in adult dogs. All dogs would benefit from early diagnosis, but there are no specific guidelines regarding the schedule of cancer screening in companion animals. The aim of this study was to retrospectively evaluate the age at diagnosis in Italian oncological canine patients. A total of 14,636 canine histologically confirmed neoplastic cases were coded according to the Vet-ICD-O-canine-1 and stratified by malignancy, sex, neutering status, breed, cephalic index, body size, and tumor type. Differences in age distribution were analyzed and the influence of these variables on the time of first malignancy diagnosis was assessed using an event history analysis model. The median age at diagnosis for benign and malignant tumors was 9 and 10 years, respectively. Intact and purebred dogs were diagnosed earlier, but the median age differed significantly by breed. The earliest age at diagnosis was recorded for lymphomas and mast cell tumors. The model showed an accelerating effect of large size, brachy- and dolichocephaly, and sexual integrity in female dogs on the time of malignancy diagnosis. Our results confirm that a "one-size-fits-all" approach to cancer screening is not accurate in dogs and provide relevant data that may lead to the establishment of breed-based screening schedules. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Ranolazine Unveiled: Rediscovering an Old Solution in a New Light.

Author

De Santis, Giulia Azzurra, De Ferrari, Tommaso, Parisi, Francesca, Franzino, Marco, Molinero, Agustin Ezequiel, Di Carlo, Alessandro, Pistelli, Lorenzo, Vetta, Giampaolo, Parlavecchio, Antonio, Torre, Marco, Parollo, Matteo, Mansi, Giacomo, Tamborrino, Pietro Paolo, Canu, Antonio, Grifoni, Gino, Segreti, Luca, Di Cori, Andrea, Viani, Stefano Marco, and Zucchelli, Giulio

Subjects
VENTRICULAR arrhythmia, ARRHYTHMIA, VENTRICULAR fibrillation, ATRIAL arrhythmias, ATRIAL fibrillation
Abstract

Ranolazine is an anti-anginal medication that has demonstrated antiarrhythmic properties by inhibiting both late sodium and potassium currents. Studies have shown promising results for ranolazine in treating both atrial fibrillation and ventricular arrhythmias, particularly when used in combination with other medications. This review explores ranolazine's mechanisms of action and its potential role in cardiac arrhythmias treatment in light of previous clinical studies. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Placental Bioenergetics and Antioxidant Homeostasis in Maternal Obesity and Gestational Diabetes.

Author

Mandò, Chiara, Castiglioni, Sara, Novielli, Chiara, Anelli, Gaia Maria, Serati, Anaïs, Parisi, Francesca, Lubrano, Chiara, Zocchi, Monica, Ottria, Roberta, and Giovarelli, Matteo

Subjects
ADENOSINE triphosphatase, OBESITY in women, CHARGE exchange, FETAL development, OXYGEN consumption, GESTATIONAL diabetes
Abstract

Maternal obesity has been associated with short- and long-term risks of pregnancy-perinatal adverse events, possibly due to alterations of placental mitochondrial bioenergetics. However, several detrimental mechanisms occurring in the placentas of women with obesity still need to be clarified. Here, we analyzed placental mitochondrial features and oxidative environment of 46 pregnancies in relation to pre-pregnancy BMI. Seventeen Caucasian normal-weight (NW) and twenty-nine women who were obese (OB) were enrolled. The protein expression of mitochondrial CypD and electron transfer chain complexes (C) I–V were measured, as well as ATP production and oxygen consumption rates (OCRs). The protein levels of the pro/anti-oxidant enzymes TXNIP, SOD2, and PON2 were also analyzed. Despite no differences in CypD expression, OCRs were significantly lower in OB vs. NW women. Accordingly, ATP synthase (CV) levels and ATP content were decreased in OB women, positively correlating with placental efficiency, suggesting a link between ATP deficiency and placental dysfunction. SOD2 expression negatively correlated with maternal BMI, indicating a possible impairment of antioxidant defenses with increasing BMI. These changes were worsened in 10 OB women presenting with gestational diabetes mellitus. Overall, these results suggest alterations of placental bioenergetics in pregnancies of women with obesity, possibly leading to placental dysfunction and altered fetal development and programming. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Histiocytic Sarcoma in a Captive Hybrid Orangutan (Pongo sp.): Morphological and Immunohistochemical Features.

Author

Galietta, Valentina, Fonti, Niccolò, Cocumelli, Cristiano, Raso, Caterina, Di Cerbo, Pilar, Parisi, Francesca, Bovi, Emanuela, Parmigiani, Raffaella, Pietrella, Gabriele, Cersini, Antonella, Friedrich, Klaus G., and Eleni, Claudia

Subjects
RETICULUM cell sarcoma, ORANGUTANS, HEMATOLOGIC malignancies, ANIMAL species, SYMPTOMS, PRIMATES
Abstract

Simple Summary: Histiocytic sarcoma (HS), a rare and highly aggressive cancer of histiocytic origin, has been identified across various animal species, including sporadic cases in non-human primates. This research presents the initial documented instance of disseminated HS in a captive orangutan. The clinical presentation closely resembled symptoms observed in human HS cases. A thorough examination of tissue samples revealed typical features of this cancer through histopathology, and the diagnosis was confirmed using immunohistochemistry, employing markers such as Iba-1 and HLA-DR. Notably, the lack of expression of CD163 and CD204 challenges their effectiveness as diagnostic indicators in non-human primates. This investigation contributes to our comprehension of diagnosing HS in non-human primates, emphasizing the importance of standardized markers and diagnostic procedures. Histiocytic sarcoma (HS), an infrequent highly aggressive hematopoietic tumor, has been observed in diverse animal species, with isolated occurrences in non-human primates. This study describes the first case of disseminated HS in a 45-year-old female hybrid captive orangutan. The clinical profile mirrored symptoms seen in human HS cases, encompassing anorexia and ascites. Detailed histopathological examination demonstrated characteristic features of this tumor and immunohistochemistry, using markers such as Iba-1 and HLA-DR, confirmed the diagnosis. Significantly, the absence of CD163 and CD204 expression challenges their diagnostic utility in non-human primates. This investigation enhances our understanding of HS diagnosis in non-human primates, underscoring the necessity for standardized markers and diagnostic protocols. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The Long-Term Benefit of Sacubitril/Valsartan in Patients with HFrEF: A 5-Year Follow-Up Study in a Real World Population

Author

Dattilo, Giuseppe, primary, Laterra, Giulia, additional, Licordari, Roberto, additional, Parisi, Francesca, additional, Pistelli, Lorenzo, additional, Colarusso, Luigi, additional, Zappia, Luca, additional, Vaccaro, Vittoria, additional, Demurtas, Elisabetta, additional, Allegra, Marta, additional, Crea, Pasquale, additional, Di Bella, Gianluca, additional, Signorelli, Salvatore Santo, additional, Aspromonte, Nadia, additional, Imbalzano, Egidio, additional, and Correale, Michele, additional

Published
2023
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18. Minipuberty assessment in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia: a single-center case–control study

Author

Lanciotti, Lucia, primary, Sica, Rossella, additional, Penta, Laura, additional, Parisi, Francesca, additional, Argentiero, Alberto, additional, Radicioni, Maurizio, additional, Di Cara, Giuseppe, additional, Di Genova, Francesca, additional, Verrotti, Alberto, additional, Troiani, Stefania, additional, and Esposito, Susanna Maria Roberta, additional

Published
2023
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19. Keep me safe at home! Epidemiological study on domestic injuries among children and risk of hospitalization

Author

Bezzini, Daiana, primary, Amaddeo, Alessandro, additional, Bondone, Claudia, additional, Calvi, Matteo, additional, Canetto, Alessandro, additional, Gaiero, Alberto, additional, Grosso, Salvatore, additional, Lanari, Marcello, additional, Liguoro, Ilaria, additional, Lombardi, Francesca, additional, Manieri, Sergio, additional, Marchetti, Federico, additional, Parisi, Francesca, additional, Raffaele, Carmela, additional, Reale, Antonino, additional, Silenzi, Francesco, additional, Silvagni, Davide, additional, and Schiavetti, Irene, additional

Published
2023
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20. Second-line treatment outcomes after progression from first-line chemotherapy plus immunotherapy in patients with advanced non-small cell lung cancer

Author

Auclin, Edouard, Benitez-Montanez, Jose, Tagliamento, Marco, Parisi, Francesca, Gorria, Teresa, Garcia-Campelo, Rosario, Dempsey, Naomi, Pinato, David J., Reyes, Roxana, Albarran-Artahona, Victor, Dall'Olio, Filippo, Soldato, Davide, Hendriks, Lizza, Nana, Frank Aboubakar, Tonneau, Marion, Lopez-Castro, Rafael, Nadal, Ernest, Kazandjian, Suzanne, Muanza, Thierry, Blanc-Durand, Felix, Fabre, Elizabeth, Castro, Natalia, Arasanz, Hugo, Rochand, Adrien, Besse, Benjamin, Routy, Bertrand, Mezquita, Laura, Auclin, Edouard, Benitez-Montanez, Jose, Tagliamento, Marco, Parisi, Francesca, Gorria, Teresa, Garcia-Campelo, Rosario, Dempsey, Naomi, Pinato, David J., Reyes, Roxana, Albarran-Artahona, Victor, Dall'Olio, Filippo, Soldato, Davide, Hendriks, Lizza, Nana, Frank Aboubakar, Tonneau, Marion, Lopez-Castro, Rafael, Nadal, Ernest, Kazandjian, Suzanne, Muanza, Thierry, Blanc-Durand, Felix, Fabre, Elizabeth, Castro, Natalia, Arasanz, Hugo, Rochand, Adrien, Besse, Benjamin, Routy, Bertrand, and Mezquita, Laura

Abstract

Introduction: Chemotherapy plus immunotherapy is the standard of care for patients with metastatic NSCLC. No study has evaluated the outcomes of second-line chemotherapy treatments after progression following first-line chemo-immunotherapy. Method: This multicenter retrospective study evaluated the efficacy of second line (2L) chemotherapies after progression under first-line (1L) chemo-immunotherapy, measured by overall survival (2L-OS) and progression free survival (2L-PFS). Results: A total of 124 patients were included. The mean age was 63.1 years, 30.6 % of the patients were female, 72.6 % had an adenocarcinoma and 43.5 % had a poor ECOG-performance status prior to 2L initiation. Sixty-four (52.0 %) patients were considered resistant to first line chemo-immunotherapy. (1L-PFS < 6 months). In 2L treatments, 57 (46.0 %) patients received taxane monotherapy, 25 (20.1 %) taxane plus anti-angiogenic, 12 (9.7 %) platinum-based chemotherapy and 30 (24.2 %) other chemotherapy.

Published
2023

25. Gliflozins: From Antidiabetic Drugs to Cornerstone in Heart Failure Therapy—A Boost to Their Utilization and Multidisciplinary Approach in the Management of Heart Failure

Author

Pistelli, Lorenzo, primary, Parisi, Francesca, additional, Correale, Michele, additional, Cocuzza, Federica, additional, Campanella, Francesca, additional, de Ferrari, Tommaso, additional, Crea, Pasquale, additional, De Sarro, Rosalba, additional, La Cognata, Olga, additional, Ceratti, Simona, additional, Recupero, Tonino, additional, Ruocco, Gaetano, additional, Palazzuoli, Alberto, additional, Imbalzano, Egidio, additional, and Dattilo, Giuseppe, additional

Published
2023
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27. Skeletal muscle dissemination in a dog with T‐cell lymphoma

Author

Magni, Tommaso, primary, Signore, Francesca Del, additional, Vignoli, Massimo, additional, Terragni, Rossella, additional, Poli, Alessandro, additional, Parisi, Francesca, additional, Sampaolo, Michele, additional, Boari, Andrea, additional, Miglio, Arianna, additional, and Crisi, Paolo Emidio, additional

Published
2022
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28. 380 CARDIAC AND VASCULAR IMPAIRMENT IN PATIENTS WITH MILD PSORIASIS: A LONGITUDINAL STUDY

Author

Cocuzza, Federica, primary, Carciotto, Gabriele, additional, Pistelli, Lorenzo, additional, Parisi, Francesca, additional, De Murtas, Elisabetta, additional, Poleggi, Cristina, additional, Campanella, Francesca, additional, De Sarro, Rosalba, additional, Vinciguerra, Paolo, additional, Imbalzano, Egidio, additional, Di Bella, Gianluca, additional, Micari, Antonio, additional, Dattilo, Giuseppe, additional, and Casale, Matteo, additional

Published
2022
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29. 381 PROGNOSTIC VALUE OF TWO DIMENSIONAL STRAIN IN EARLY ISCHEMIC HEART DISEASE: A 5-YEAR FOLLOW-UP STUDY

Author

Campanella, Francesca, primary, Licordari, Roberto, additional, Pistelli, Lorenzo, additional, Parisi, Francesca, additional, Cocuzza, Federica, additional, Allegra, Marta, additional, Lo Savio, Armando, additional, La Cognata, Olga, additional, Poleggi, Cristina, additional, De Sarro, Rosalba, additional, Morabito, Claudia, additional, Crea, Pasquale, additional, Imbalzano, Egidio, additional, Micari, Antonio, additional, Di Bella, Gianluca, additional, and Dattilo, Giuseppe, additional

Published
2022
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30. 746 DAL COMPASS AI DATI DI REAL LIFE: UNO STUDIO CASO-CONTROLLO

Author

Poleggi, Cristina, primary, Luongo, Alfredo, additional, De Sarro, Rosalba, additional, Lo Savio, Armando, additional, La Cognata, Olga, additional, Cocuzza, Federica, additional, Restelli, Davide, additional, Parisi, Francesca, additional, Pistelli, Lorenzo, additional, Allegra, Marta, additional, Crea, Pasquale, additional, Micari, Antonio, additional, Di Bella, Gianluca, additional, and Dattilo, Giuseppe, additional

Published
2022
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32. 772 SCREENING FOR ANDERSON-FABRY DISEASE IN RELATIVELY YOUNG PATIENTS WITH UNEXPLAINED CONDUCTION DISORDERS REQUIRING PACEMAKER IMPLANTATION

Author

Allegra, Marta, primary, Crea, Pasquale, additional, Poleggi, Cristina, additional, Mancinelli, Anna, additional, Parisi, Francesca, additional, Dattilo, Giuseppe, additional, Licordari, Roberto, additional, Demurtas, Elisabetta, additional, Giuffrida, Giulia, additional, Carerj, Scipione, additional, Micari, Antonio, additional, and Bella, Gianluca Di, additional

Published
2022
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33. Frequency and type of domestic injuries among children during COVID-19 lockdown: what changes from the past? An Italian multicentre cohort study

Author

Bezzini, Daiana, Lanari, Marcello, Amaddeo, Alessandro, Aricò, Melodie O, Castagno, Emanuele, Cherchi, Gabriella, Giacomini, Giulia, Graziani, Giulia, Grosso, Salvatore, Liguoro, Ilaria, Lombardi, Francesca, Manieri, Sergio, Moschettini, Laura, Parisi, Francesca, Reale, Antonino, Romanisio, Giulia, Silvagni, Davide, and Schiavetti, Irene

Subjects
Hospitalization, Accident, Incidence, Accident, Home, Hospitalization, Incidence, Home
Published
2023

37. Immune Checkpoint Blockade: A Strategy to Unleash the Potential of Natural Killer Cells in the Anti-Cancer Therapy

Author

Grottoli, Melania, primary, Carrega, Paolo, additional, Zullo, Lodovica, additional, Dellepiane, Chiara, additional, Rossi, Giovanni, additional, Parisi, Francesca, additional, Barletta, Giulia, additional, Zinoli, Linda, additional, Coco, Simona, additional, Alama, Angela, additional, Marconi, Silvia, additional, Parodi, Monica, additional, Orecchia, Paola, additional, Bassi, Sara, additional, Vitale, Massimo, additional, Mingari, Maria Cristina, additional, Pfeffer, Ulrich, additional, Genova, Carlo, additional, and Pietra, Gabriella, additional

Published
2022
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40. Associations between Maternal Dietary Patterns, Biomarkers and Delivery Outcomes in Healthy Singleton Pregnancies: Multicenter Italian GIFt Study

Author

Anelli, Gaia Maria, primary, Parisi, Francesca, additional, Sarno, Laura, additional, Fornaciari, Ottavia, additional, Carlea, Annunziata, additional, Coco, Chiara, additional, Porta, Matteo Della, additional, Mollo, Nunzia, additional, Villa, Paola Maria, additional, Guida, Maurizio, additional, Cazzola, Roberta, additional, Troiano, Ersilia, additional, Pasotti, Monica, additional, Volpi, Graziella, additional, Vetrani, Laura, additional, Maione, Manuela, additional, and Cetin, Irene, additional

Published
2022
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49. 686 Coronary lesion distribution in young patient presenting with acute coronary syndrome

Author

Franzino, Marco, primary, Pistelli, Lorenzo, additional, Parisi, Francesca, additional, De Santis, Giulia Azzurra, additional, Nicolò, Claudio, additional, Andò, Giuseppe, additional, Virga, Vittorio, additional, Vizzari, Giampiero, additional, Saporito, Francesco, additional, Carerj, Scipione, additional, Di Bella, Gianluca, additional, Micari, Antonio, additional, and Costa, Francesco, additional

Published
2021
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50. 636 Global cardiovascular assessment in patients with PH+ chronic myeloid leukaemia treated with TKI: long-term follow-up

Author

Demurtas, Elisabetta, primary, Piccione, Maurizio Cusma, additional, Parisi, Francesca, additional, Vinciguerra, Paolo, additional, Caminiti, Rodolfo, additional, Manganaro, Roberta, additional, Russo, Sabina, additional, Musolino, Caterina, additional, Micari, Antonio, additional, Zito, Concetta, additional, Di Bella, Gianluca, additional, and Carerj, Scipione, additional

Published
2021
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