74 results on '"Pagava K"'
Search Results
2. The worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children
- Author
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Versporten A1, Bielicki J2, Drapier N1, Sharland M2, Goossens H3, ARPEC project group. Calle GM, Garrahan JP, Clark J, Cooper C, Blyth CC, Francis JR, Alsalman J, Jansens H, Mahieu L, Van Rossom P, Vandewal W, Lepage P, Blumental S, Briquet C, Robbrecht D, Maton P, Gabriels P, Rubic Z, Kovacevic T, Nielsen JP, Petersen JR, Poorisrisak P, Jensen LH, Laan M, Tamm E, Matsinen M, Rummukainen ML, Gajdos V, Olivier R, Le Maréchal F, Martinot A, Dubos F, Lagrée M, Prot-Labarthe S, Lorrot M, Orbach D, Pagava K, Hufnagel M, Knuf M, Schlag SA, Liese J, Renner L, Enimil A, Awunyo M, Syridou G, Spyridis N, Critselis E, Kouni S, Mougkou K, Ladomenou F, Gkentzi D, Iosifidis E, Roilides E, Sahu S, Murki S, Malviya M, Kalavalapalli DB, Singh S, Singhal T, Garg G, Garg P, Kler N, Soltani J, Jafarpour Z, Pouladfar G, Nicolini G, Montagnani C, Galli L, Esposito S, Tenconi R, Lo Vecchio A, Dona' D, Giaquinto C, Borgia E, D'Argenio P, De Luca M, Centenari C, Raka L, Raka D, Omar A, Al-Mousa H, Mozgis D, Sviestina I, Burokiene S, Usonis V, Tavchioska G, Hargadon-Lowe A, Zarb P, Borg MA, González Lozano CA, Zárate Castañon P, Cancino ME, McCullagh B, McCorry A, Gormley C, Al Maskari Z, Al-Jardani A, Pluta M, Rodrigues F, Brett A, Esteves I, Marques L, Ali AlAjmi J, Claudia Cambrea S, Rashed AN, Mubarak Al Azmi AA, Chan SM, Isa MS, Najdenov P, Čižman M, Unuk S, Finlayson H, Dramowski A, Maté-Cano I, Soto B, Calvo C, Santiago B, Saavedra-Lozano J, Bustinza A, Escosa-García L, Ureta N, Lopez-Varela E, Rojo P, Tagarro A, Barrero PT, Rincon-Lopez EM, Abubakar I, Aston J, Heginbothom M, Satodia P, Garbash M, Johnson A, Sharpe D, Barton C, Menson E, Arenas-Lopez S, Luck S, Doerholt K, McMaster P, Caldwell NA, Lunn A, Drysdale SB, Howe R, Scorrer T, Gahleitner F, Gupta R, Nash C, Alexander J, Raman M, Bell E, Rajagopal V, Kohlhoff S, Cox E, Zaoutis T., Mahieu, Ludo, ARPEC Project Grp, ARPEC project group, Versporten, A1, Bielicki, J2, Drapier, N1, Sharland, M2, Goossens, H3, ARPEC project group., Calle GM, Garrahan, Jp, Clark, J, Cooper, C, Blyth, Cc, Francis, Jr, Alsalman, J, Jansens, H, Mahieu, L, Van Rossom, P, Vandewal, W, Lepage, P, Blumental, S, Briquet, C, Robbrecht, D, Maton, P, Gabriels, P, Rubic, Z, Kovacevic, T, Nielsen, Jp, Petersen, Jr, Poorisrisak, P, Jensen, Lh, Laan, M, Tamm, E, Matsinen, M, Rummukainen, Ml, Gajdos, V, Olivier, R, Le Maréchal, F, Martinot, A, Dubos, F, Lagrée, M, Prot-Labarthe, S, Lorrot, M, Orbach, D, Pagava, K, Hufnagel, M, Knuf, M, Schlag, Sa, Liese, J, Renner, L, Enimil, A, Awunyo, M, Syridou, G, Spyridis, N, Critselis, E, Kouni, S, Mougkou, K, Ladomenou, F, Gkentzi, D, Iosifidis, E, Roilides, E, Sahu, S, Murki, S, Malviya, M, Kalavalapalli, Db, Singh, S, Singhal, T, Garg, G, Garg, P, Kler, N, Soltani, J, Jafarpour, Z, Pouladfar, G, Nicolini, G, Montagnani, C, Galli, L, Esposito, S, Tenconi, R, Lo Vecchio, A, Dona', D, Giaquinto, C, Borgia, E, D'Argenio, P, De Luca, M, Centenari, C, Raka, L, Raka, D, Omar, A, Al-Mousa, H, Mozgis, D, Sviestina, I, Burokiene, S, Usonis, V, Tavchioska, G, Hargadon-Lowe, A, Zarb, P, Borg, Ma, González Lozano, Ca, Zárate Castañon, P, Cancino, Me, Mccullagh, B, Mccorry, A, Gormley, C, Al Maskari, Z, Al-Jardani, A, Pluta, M, Rodrigues, F, Brett, A, Esteves, I, Marques, L, Ali AlAjmi, J, Claudia Cambrea, S, Rashed, An, Mubarak Al Azmi, Aa, Chan, Sm, Isa, M, Najdenov, P, Čižman, M, Unuk, S, Finlayson, H, Dramowski, A, Maté-Cano, I, Soto, B, Calvo, C, Santiago, B, Saavedra-Lozano, J, Bustinza, A, Escosa-García, L, Ureta, N, Lopez-Varela, E, Rojo, P, Tagarro, A, Barrero, Pt, Rincon-Lopez, Em, Abubakar, I, Aston, J, Heginbothom, M, Satodia, P, Garbash, M, Johnson, A, Sharpe, D, Barton, C, Menson, E, Arenas-Lopez, S, Luck, S, Doerholt, K, Mcmaster, P, Caldwell, Na, Lunn, A, Drysdale, Sb, Howe, R, Scorrer, T, Gahleitner, F, Gupta, R, Nash, C, Alexander, J, Raman, M, Bell, E, Rajagopal, V, Kohlhoff, S, Cox, E, and Zaoutis, T.
- Subjects
0301 basic medicine ,Male ,Pediatrics ,Latin Americans ,Cross-sectional study ,Prevalence ,Psychological intervention ,Drug resistance ,Global Health ,infectious diseases ,0302 clinical medicine ,Global health ,Medicine ,030212 general & internal medicine ,Child ,antibiotics, children ,Drugs -- Prescribing ,Pharmacology. Therapy ,Hospitals -- Europe ,Drug Resistance, Microbial ,Hospitals ,Anti-Bacterial Agents ,Europe ,Child, Preschool ,Anti-infective agents ,Female ,medicine.drug ,Microbiology (medical) ,medicine.medical_specialty ,Cefepime ,030106 microbiology ,Drug Prescriptions ,03 medical and health sciences ,Surgical prophylaxis ,pharmacology ,pharmacology (medical) ,Environmental health ,Humans ,Biology ,Quality Indicators, Health Care ,business.industry ,Health status indicators -- Europe ,Infant ,Drug Utilization ,Cross-Sectional Studies ,Health Care Surveys ,Human medicine ,business - Abstract
Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Methods: A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Results: Of 17693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusions: Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to monitor future interventions in hospitalized neonates and children. To our knowledge, this study has derived the first global quality indicators for antibiotic use in hospitalized neonates and children., peer-reviewed
- Published
- 2018
3. Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas. The PRINTO multinational quality of life cohort study
- Author
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Gutiérrez-Suárez, R., Pistorio, A., Cruz, A. Cespedes, Norambuena, X., Flato, B., Rumba, I., Harjacek, M., Nielsen, S., Susic, G., Mihaylova, D., Huemer, C., Melo-Gomes, J., Andersson-Gare, B., Balogh, Z., De Cunto, C., Vesely, R., Pagava, K., Romicka, A. M., Burgos-Vargas, R., Martini, A., and Ruperto, N.
- Published
- 2007
4. PRINTO/PRES international website for families of children with rheumatic diseases: www.pediatric-rheumatology.printo.it
- Author
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Ruperto, N, Garcia-Munitis, P, Villa, L, Pesce, M, Aggarwal, A, Fasth, A, Avcin, T, Bae, S-C, Balogh, Z, Li, C, De Inocencio, J, Dibra, M, Dolezalova, P, Miedany, Y El, Flato, B, Harjacek, M, Huppertz, H-I, Kanakoudi-Tsakalidou, F, Wulffraat, N, Lahdenne, P, Melo-Gomes, J A, Mihaylova, D, Nielsen, S, Nikishina, I, Ozdogan, H, Pagava, K, Panaviene, V, Prieur, A-M, Romicka, A-M, Rumba, I, Shafaie, N, Susic, G, Takei, S, Uziel, Y, Vesely, R, Woo, P, and Martini, A
- Published
- 2005
5. Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study
- Author
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Consolaro, A, Giancane, G, Alongi, A, van Dijkhuizen, Ehp, Aggarwal, A, Al-Mayouf, Sm, Bovis, F, De Inocencio, J, Demirkaya, E, Flato, B, Foell, D, Garay, Sm, Lazăr, C, Lovell, Dj, Montobbio, C, Miettunen, P, Mihaylova, D, Nielsen, S, Orban, I, Rumba-Rozenfelde, I, Magalhães, C, Shafaie, N, Susic, G, Trachana, M, Wulffraat, N, Pistorio, A, Martini, A, Ruperto, N, Ravelli, A &, Abdwani R, Aghighi, Y, Aiche, Mf, Ailioaie, C, Aktay Ayaz, N, Al-Abrawi, S, Alexeeva, E, Anton, J, Apostol, A, Arguedas, O, Avcin, T, Barone, P, Berntson, L, Boteanu, Al, Boyko, Y, Burgos-Vargas, R, Calvo Penades, I, Chédeville, G, Cimaz, R, Civino, A, Consolini, R, Constantin, T, Cuttica, R, Dallos, T, Martin, N, Magni-Manzoni, S, De Cunto, C, Dolezalova, P, Ekelund, M, El Miedany, Y, Espada, G, Estmann Christensen, A, Foeldvari, I, Gallizzi, R, Ganser, G, Gerloni, V, Haas, Jp, Harel, L, Harjacek, M, Hashad, S, Herlin, T, Herrera, C, Hofer, M, Holzinger, D, Horneff, G, Huppertz, Hi, Iagăru, N, Ibanez Estrella, A, Ioseliani, M, Joos, R, Knupp Oliveira, S, Kamphuis, S, Kasapcopur, O, Katsicas, Mm, Khubchandani, R, Kondi, A, Kröger, L, La Torre, F, Laday, M, Lahdenne, P, Maggio, Mc, Magnolia, Mg, Malagon, C, Malin, M, Martino, S, Melo-Gomes, Ja, Mesa-Del-Castillo, P, Militaru, A, Minden, K, Miniaci, A, Moradinejad, Mh, Morel Ayala, Z, Nikishina, I, Norambuena, X, Nordal, Eb, Pagava, K, Panaviene, V, Pastore, S, Pieropan, S, Podda, Ra, Pruunsild, C, Putto-Laurila, A, Quartier, P, Remesal, A, Rigante, Donato, Ringold, S, Rutkowska-Sak, L, Rygg, M, Saurenmann, Rk, Sawhney, S, Scott, C, Shiari, R, Smolewska, E, Sozeri, B, Swart, Jf, Sztajnbok, F, Torcoletti, M, Tsitsami, E, Tzaribachev, N, Unsal, E, Uziel, Y, Vähäsalo, P, Varbanova, B, Vargova, V, Vesely, R, Vijatov-Djuric, G, Vilaiyuk, S, Vojinovic, J, Vougiouka, O, Weiss, P, Wouters, C, Rigante D (ORCID:0000-0001-7032-7779), Consolaro, A, Giancane, G, Alongi, A, van Dijkhuizen, Ehp, Aggarwal, A, Al-Mayouf, Sm, Bovis, F, De Inocencio, J, Demirkaya, E, Flato, B, Foell, D, Garay, Sm, Lazăr, C, Lovell, Dj, Montobbio, C, Miettunen, P, Mihaylova, D, Nielsen, S, Orban, I, Rumba-Rozenfelde, I, Magalhães, C, Shafaie, N, Susic, G, Trachana, M, Wulffraat, N, Pistorio, A, Martini, A, Ruperto, N, Ravelli, A &, Abdwani R, Aghighi, Y, Aiche, Mf, Ailioaie, C, Aktay Ayaz, N, Al-Abrawi, S, Alexeeva, E, Anton, J, Apostol, A, Arguedas, O, Avcin, T, Barone, P, Berntson, L, Boteanu, Al, Boyko, Y, Burgos-Vargas, R, Calvo Penades, I, Chédeville, G, Cimaz, R, Civino, A, Consolini, R, Constantin, T, Cuttica, R, Dallos, T, Martin, N, Magni-Manzoni, S, De Cunto, C, Dolezalova, P, Ekelund, M, El Miedany, Y, Espada, G, Estmann Christensen, A, Foeldvari, I, Gallizzi, R, Ganser, G, Gerloni, V, Haas, Jp, Harel, L, Harjacek, M, Hashad, S, Herlin, T, Herrera, C, Hofer, M, Holzinger, D, Horneff, G, Huppertz, Hi, Iagăru, N, Ibanez Estrella, A, Ioseliani, M, Joos, R, Knupp Oliveira, S, Kamphuis, S, Kasapcopur, O, Katsicas, Mm, Khubchandani, R, Kondi, A, Kröger, L, La Torre, F, Laday, M, Lahdenne, P, Maggio, Mc, Magnolia, Mg, Malagon, C, Malin, M, Martino, S, Melo-Gomes, Ja, Mesa-Del-Castillo, P, Militaru, A, Minden, K, Miniaci, A, Moradinejad, Mh, Morel Ayala, Z, Nikishina, I, Norambuena, X, Nordal, Eb, Pagava, K, Panaviene, V, Pastore, S, Pieropan, S, Podda, Ra, Pruunsild, C, Putto-Laurila, A, Quartier, P, Remesal, A, Rigante, Donato, Ringold, S, Rutkowska-Sak, L, Rygg, M, Saurenmann, Rk, Sawhney, S, Scott, C, Shiari, R, Smolewska, E, Sozeri, B, Swart, Jf, Sztajnbok, F, Torcoletti, M, Tsitsami, E, Tzaribachev, N, Unsal, E, Uziel, Y, Vähäsalo, P, Varbanova, B, Vargova, V, Vesely, R, Vijatov-Djuric, G, Vilaiyuk, S, Vojinovic, J, Vougiouka, O, Weiss, P, Wouters, C, and Rigante D (ORCID:0000-0001-7032-7779)
- Abstract
BACKGROUND: To our knowledge, the characteristics and burden of childhood arthritis have never been studied on a worldwide basis. We aimed to investigate, with a cross-sectional study, the prevalence of disease categories, treatment methods, and disease status in patients from across different geographical areas and from countries with diverse wealth status. METHODS: In this multinational, cross-sectional, observational cohort study, we asked international paediatric rheumatologists from specialised centres to enrol children with a diagnosis of juvenile idiopathic arthritis, according to International League of Associations for Rheumatology criteria, who were seen consecutively for a period of 6 months. Each patient underwent retrospective and cross-sectional assessments, including measures of disease activity and damage and questionnaires on the wellbeing and quality of life of the children. We qualitatively compared the collected data across eight geographical areas, and we explored an association between disease activity and damage and a country's gross domestic product (GDP) with a multiple logistic regression analysis. FINDINGS: Between April 4, 2011, and Nov 21, 2016, 9081 patients were enrolled at 130 centres in 49 countries, grouped into eight geographical areas. Systemic arthritis (125 [33·0%] of 379 patients) and enthesitis-related arthritis (113 [29·8%] of 379) were more common in southeast Asia, whereas oligoarthritis was more prevalent in southern Europe (1360 [56·7%] of 2400) and rheumatoid factor-negative polyarthritis was more frequent in North America (165 [31·5%] of 523) than in the other areas. Prevalence of uveitis was highest in northern Europe (161 [19·1%] of 845 patients) and southern Europe (450 [18·8%] of 2400) and lowest in Latin America (54 [6·4%] of 849), Africa and Middle East (71 [5·9%] of 1209), and southeast Asia (19 [5·0%] of 379). Median age at disease onset was lower in southern Europe (3·5 years, IQR 1·9-7·3) than in other regions
- Published
- 2019
6. The worldwide antibiotic resistance and prescribing in european children (ARPEC) point prevalence survey: Developing hospital-quality indicators of antibiotic prescribing for children
- Author
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Versporten, A. Bielicki, J. Drapier, N. Sharland, M. Goossens, H. Calle, G.M. Clark, J. Cooper, C. Blyth, C.C. Francis, J.R. Alsalman, J. Jansens, H. Mahieu, L. Van Rossom, P. Vandewal, W. Lepage, P. Blumental, S. Briquet, C. Robbrecht, D. Maton, P. Gabriels, P. Rubic, Z. Kovacevic, T. Nielsen, J.P. Petersen, J.R. Poorisrisak, P. Jensen, L.H. Laan, M. Tamm, E. Matsinen, M. Rummukainen, M.-L. Gajdos, V. Olivier, R. Le Maréchal, F. Martinot, A. Prot-Labarthe, S. Lorrot, M. Orbach, D. Pagava, K. Hufnagel, M. Knuf, M. Schlag, S.A.A. Liese, J. Renner, L. Enimil, A. Awunyo, M. Syridou, G. Spyridis, N. Critselis, E. Kouni, S. Mougkou, K. Ladomenou, F. Gkentzi, D. Iosifidis, E. Roilides, E. Sahu, S. Murki, S. Malviya, M. Kalavalapalli, D.B. Singh, S. Singhal, T. Garg, G. Garg, P. Kler, N. Soltani, J. Jafarpour, Z. Pouladfar, G. Nicolini, G. Montagnani, C. Galli, L. Esposito, S. Vecchio, A.L. Dona', D. Giaquinto, C. Borgia, E. D'Argenio, P. De Luca, M. Centenari, C. Raka, L. Omar, A. Al-Mousa, H. Mozgis, D. Sviestina, I. Burokiene, S. Usonis, V. Tavchioska, G. Hargadon-Lowe, A. Zarb, P. Borg, M.A. González Lozano, C.A. Castañon, P.Z. Cancino, M.E. McCullagh, B. McCorry, A. Gormley, C. Al Maskari, Z. Al-Jardani, A. Pluta, M. Rodrigues, F. Brett, A. Esteves, I. Marques, L. AlAjmi, J.A. Cambrea, S.C. Rashed, A.N. Al Azmi, A.A.M. Chan, S.M. Isa, M.S. Najdenov, P. Čižman, M. Unuk, S. Finlayson, H. Dramowski, A. Maté-Cano, I. Soto, B. Calvo, C. Santiago, B. Saavedra-Lozano, J. Bustinza, A. Escosa-García, L. Ureta, N. Tagarro, A. Barrero, P.T. Rincon-Lopez, E.M. Abubakar, I. Aston, J. Heginbothom, M. Satodia, P. Garbash, M. Johnson, A. Sharpe, D. Barton, C. Menson, E. Arenas-Lopez, S. Luck, S. Doerholt, K. McMaster, P. Caldwell, N.A. Lunn, A. Drysdale, S.B. Howe, R. Scorrer, T. Gahleitner, F. Gupta, R. Nash, C. Alexander, J. Raman, M. Bell, E. Rajagopal, V. Kohlhoff, S. Cox, E. Zaoutis, T. ARPEC project group
- Abstract
Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Methods: A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Results: Of 17 693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusions: Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to monitor future interventions in hospitalized neonates and children. To our knowledge, this study has derived the first global quality indicators for antibiotic use in hospitalized neonates and children. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
- Published
- 2016
7. PECULIARITIES OF NUTRITION AMONG MEDICAL UNIVERSITY STUDENTS.
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Phagava, H., Mikaberidze, A., Tavadze, O., and Pagava, K.
- Published
- 2019
8. SURVEY OF PRACTICES, KNOWLEDGE AND ATTITUDE CONCERNING ANTIBIOTICS AND ANTIMICROBIAL RESISTANCE AMONG MEDICAL UNIVERSITY STUDENTS.
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Phagava, H., Balamtsarashvili, T., Pagava, K., and Mchedlishvili, I.
- Published
- 2019
9. THE GLOBAL POINT PREVALENCE SURVEY (PPS) OF ANTIMICROBIAL USE AND ANTIMICROBIAL RESISTANCE AMONG HOSPITALIZED CHILDREN IN GEORGIA.
- Author
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Korinteli, I. G., Mchedlishvili, I., Javakhadze, M., Versporten, A., Goossens, H., Phagava, H., and Pagava, K.
- Published
- 2019
10. The worldwide antibiotic resistance and prescribing in european children (ARPEC) point prevalence survey: Developing hospital-quality indicators of antibiotic prescribing for children.
- Author
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Soltani J., Kovacevic T., Nielsen J.P., Petersen J.R., Poorisrisak P., Jensen L.H., Laan M., Tamm E., Matsinen M., Rummukainen M.-L., Gajdos V., Olivier R., Le Marechal F., Martinot A., Prot-Labarthe S., Lorrot M., Orbach D., Pagava K., Hufnagel M., Knuf M., Schlag S.A.A., Liese J., Renner L., Enimil A., Awunyo M., Syridou G., Spyridis N., Critselis E., Kouni S., Mougkou K., Ladomenou F., Gkentzi D., Iosifidis E., Roilides E., Sahu S., Murki S., Malviya M., Kalavalapalli D.B., Singh S., Singhal T., Garg G., Garg P., Kler N., Jafarpour Z., Pouladfar G., Nicolini G., Montagnani C., Galli L., Esposito S., Vecchio A.L., Dona' D., Giaquinto C., Borgia E., D'Argenio P., De Luca M., Centenari C., Raka L., Omar A., Al-Mousa H., Mozgis D., Sviestina I., Burokiene S., Usonis V., Tavchioska G., Hargadon-Lowe A., Zarb P., Borg M.A., Gonzalez Lozano C.A., Castanon P.Z., Cancino M.E., McCullagh B., McCorry A., Gormley C., Al Maskari Z., Al-Jardani A., Pluta M., Rodrigues F., Brett A., Esteves I., Marques L., AlAjmi J.A., Cambrea S.C., Rashed A.N., Al Azmi A.A.M., Chan S.M., Isa M.S., Najdenov P., Cizman M., Unuk S., Finlayson H., Dramowski A., Mate-Cano I., Soto B., Calvo C., Santiago B., Saavedra-Lozano J., Bustinza A., Escosa-Garcia L., Ureta N., Tagarro A., Barrero P.T., Rincon-Lopez E.M., Abubakar I., Aston J., Heginbothom M., Satodia P., Garbash M., Johnson A., Sharpe D., Barton C., Menson E., Arenas-Lopez S., Luck S., Doerholt K., McMaster P., Caldwell N.A., Lunn A., Drysdale S.B., Howe R., Scorrer T., Gahleitner F., Gupta R., Nash C., Alexander J., Raman M., Bell E., Rajagopal V., Kohlhoff S., Cox E., Zaoutis T., Versporten A., Bielicki J., Drapier N., Sharland M., Goossens H., Calle G.M., Clark J., Cooper C., Blyth C.C., Francis J.R., Alsalman J., Jansens H., Mahieu L., Van Rossom P., Vandewal W., Lepage P., Blumental S., Briquet C., Robbrecht D., Maton P., Gabriels P., Rubic Z., Soltani J., Kovacevic T., Nielsen J.P., Petersen J.R., Poorisrisak P., Jensen L.H., Laan M., Tamm E., Matsinen M., Rummukainen M.-L., Gajdos V., Olivier R., Le Marechal F., Martinot A., Prot-Labarthe S., Lorrot M., Orbach D., Pagava K., Hufnagel M., Knuf M., Schlag S.A.A., Liese J., Renner L., Enimil A., Awunyo M., Syridou G., Spyridis N., Critselis E., Kouni S., Mougkou K., Ladomenou F., Gkentzi D., Iosifidis E., Roilides E., Sahu S., Murki S., Malviya M., Kalavalapalli D.B., Singh S., Singhal T., Garg G., Garg P., Kler N., Jafarpour Z., Pouladfar G., Nicolini G., Montagnani C., Galli L., Esposito S., Vecchio A.L., Dona' D., Giaquinto C., Borgia E., D'Argenio P., De Luca M., Centenari C., Raka L., Omar A., Al-Mousa H., Mozgis D., Sviestina I., Burokiene S., Usonis V., Tavchioska G., Hargadon-Lowe A., Zarb P., Borg M.A., Gonzalez Lozano C.A., Castanon P.Z., Cancino M.E., McCullagh B., McCorry A., Gormley C., Al Maskari Z., Al-Jardani A., Pluta M., Rodrigues F., Brett A., Esteves I., Marques L., AlAjmi J.A., Cambrea S.C., Rashed A.N., Al Azmi A.A.M., Chan S.M., Isa M.S., Najdenov P., Cizman M., Unuk S., Finlayson H., Dramowski A., Mate-Cano I., Soto B., Calvo C., Santiago B., Saavedra-Lozano J., Bustinza A., Escosa-Garcia L., Ureta N., Tagarro A., Barrero P.T., Rincon-Lopez E.M., Abubakar I., Aston J., Heginbothom M., Satodia P., Garbash M., Johnson A., Sharpe D., Barton C., Menson E., Arenas-Lopez S., Luck S., Doerholt K., McMaster P., Caldwell N.A., Lunn A., Drysdale S.B., Howe R., Scorrer T., Gahleitner F., Gupta R., Nash C., Alexander J., Raman M., Bell E., Rajagopal V., Kohlhoff S., Cox E., Zaoutis T., Versporten A., Bielicki J., Drapier N., Sharland M., Goossens H., Calle G.M., Clark J., Cooper C., Blyth C.C., Francis J.R., Alsalman J., Jansens H., Mahieu L., Van Rossom P., Vandewal W., Lepage P., Blumental S., Briquet C., Robbrecht D., Maton P., Gabriels P., and Rubic Z.
- Abstract
Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Method(s): A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Result(s): Of 17 693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusion(s): Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to
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- 2016
11. FAMILIAL MEDITERRANEAN FEVER IN CHILDREN AND ADOLESCENTS IN GEORGIA.
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Pagava, K., Sarkisian, T., Shonvadze, D., Korinteli, I. A., Airapetian, A., and Egiazarian, A.
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- 2014
12. SOME PERSONAL VIEWS ON PEDIATRICS AND NOT ONLY ...
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Pagava, K.
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- 2014
13. FAMILIAL MEDITERRANEAN FEVER IN GEORGIA.
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Pagava, K., Rauscher, B., Korinteli, I. A., Shonvadze, D., Kriegshauser, G., and Oberkanins, Ch.
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- 2014
14. FUZZY APPROACHES IN PEDIATRICS.
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Kiseliova, T. and Pagava, K.
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- 2014
15. SOME IMMUNOLOGICAL CHANGES IN CHILDREN WITH BACTERIAL INFECTIONS TREATED WITH BACTERIOPHAGES.
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Pagava, K., Gachechiladze, K., Metskhvarishvili, G., Korinteli, I., Hoyle, N., and Dzuliashvili, M.
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- 2012
16. PER OS GIVEN BACTERIOPHAGES CHANGES THE CLINICAL COURSE OF DISEASES CAUSED BY BACTERIAL AGENTS IN CHILDREN.
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Pagava, K., Metskhvarishvili, G., Korinteli, I., and Gongadze, T.
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- 2012
17. CAPILLAROSCOPY AND ECG PARAMETERS IN CHILDREN AND ADOLESCENTS WITH DIABETES MELLITUS TYPE I.
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Chakhunashvili, G., Jobava, N., Chakhunashvili, K., Shvangiradze, M., Chakhunashvili, D., and Pagava, K.
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- 2012
18. RARE TUBULOPATHY - PRIMARY HYPOPHOSPHATEMIC RICKETS (CASE REPORT).
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Tsanava, M., Abuladze, T., Zenaishvili, B., Kvaratskhelia, E., and Pagava, K.
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- 2011
19. THE CONGENITAL PARCIAL ERITHROBLASTOPENIA - DIAMOND-BLACKFAN ANEMIA.
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Kvezereli-Kopadze, M., Pagava, K., and Korinteli, I.
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- 2011
20. MANAGEMENT OPTIONS FOR RARE DISEASES IN CHILDREN AND ADOLESCENTS IN GEORGIA (EXPERIENCE OF THE COUNTRY WITH TRANSITIONAL ECONOMY).
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Pagava, K., Abesadze, G., Uberi, N., Korinteli, I., Paghava, I., Kvezereli-Kopadze, M., Parulava, T., Korinteli, M., and Kiseliova, T.
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- 2011
21. CLINICAL VALUE OF CHANGES IN RED BLOOD CELL ULTRASTRUCTURE AND ENERGY METABOLISM IN CHILDREN WITH CYSTIC FIBROSIS.
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Badriashvili, N., Chikovani, M., Topuridze, M., Glonti, S., Sharikadze, N., Topuria, T., and Pagava, K.
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- 2011
22. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey
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Versporten, A, Zarb, P, Caniaux, I, Gros, Mf, Drapier, N, Miller, M, Jarlier, V, Nathwani, D, Goossens, H, Global-PPS, Network, Koraqi, A, Hoxha, I, Tafaj, S, Lacej, D, Hojman, M, Quiros, Re, Ghazaryan, L, Cairns, Ka, Cheng, A, Horne, Kc, Doukas, Ff, Gottlieb, T, Alsalman, J, Magerman, K, Marielle, Gy, Ljubovic, Ad, Coelho, Aam, Gales, Ac, Keuleyan, E, Sabuda, D, Boswell, Jl, Conly, Jm, Rojas, A, Carvajal, C, Labarca, J, Solano, A, Valverde, Cr, Villalobos-Vindas, Jm, Pristas, I, Plecko, V, Paphitou, N, Shaqiri, E, Rummukainen, Ml, Pagava, K, Korinteli, I, Brandt, T, Messler, S, Enimil, A, Iosifidis, E, Roilides, E, Sow, Ms, Sengupta, S, George, Jv, Poojary, A, Patil, P, Soltani, J, Jafarpour, Z, Ameen, H, Fitzgerald, D, Maor, Y, Chowers, M, Temkin, E, Esposito, S, Arnoldo, L, Brusaferro, S, Gu, Y, El-Hajji, Fd, Kim, Nj, Kambaralieva, B, Pavare, J, Zarakauska, L, Usonis, V, Burokiene, S, Ivaskeviciene, I, Mijovic, G, Duborija-Kovacevic, N, Bondesio, K, Iregbu, K, Oduyebo, O, Raka, D, Raka, L, Rachina, S, Enani, Ma, Al Shehri, M, Carevic, B, Dragovac, G, Obradovic, D, Stojadinovic, A, Radulovic, L, Wu, Je, Wei Teng Chung, G, Chen, Hh, Tambyah, Pa, Lye, D, Tan, Sh, Ng, Tm, Tay, Hl, Ling, Ml, Chlebicki, Mp, Kwa, Al, Lee, W, Beović, B, Dramowski, A, Finlayson, H, Taljaard, J, Ojeda-Burgos, G, Retamar, P, Lucas, J, Pot, W, Verduin, C, Kluytmans, J, Scott, M, Aldeyab, Ma, Mccullagh, B, Gormley, C, Sharpe, D, Gilchrist, M, Whitney, L, Laundy, M, Lockwood, D, Drysdale, Sb, Boudreaux, J, Septimus, Ej, Greer, N, Gawrys, G, Rios, E, May, S., Centre d'Immunologie et de Maladies Infectieuses ( CIMI ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre National de Référence des Mycobactéries et de la Résistance aux Antituberculeux [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP)-Laboratoire de Bactériologie-Hygiène, CHU Pitié-Salpêtrière, 47-83 bd de l'Hôpital 75651 Paris cedex 13-CHU Pitié-Salpêtrière [APHP], BioMérieux, Global-PPS network, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Global-PpS Network
- Subjects
Adult ,Male ,0301 basic medicine ,Point prevalence survey ,medicine.medical_specialty ,medicine.drug_class ,030106 microbiology ,Antibiotics ,Central asia ,Voluntary participation ,Global Health ,Anatomy -- Case Reports ,Therapeutics -- Case studies ,03 medical and health sciences ,Anti-Infective Agents ,Internet based ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Prevalence ,Drug utilization ,Humans ,Medicine ,Medical prescription ,Internet ,business.industry ,lcsh:Public aspects of medicine ,Medicine (all) ,Drug Resistance, Microbial ,lcsh:RA1-1270 ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,General Medicine ,Antimicrobial ,Hospitals ,3. Good health ,Hospitalization ,Transplantation ,[ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Health Care Surveys ,Emergency medicine ,Anti-infective agents ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Human medicine ,business ,Antibiotics -- Drug utilization - Abstract
Background: The Global Point Prevalence Survey (Global-PPS) established an international network of hospitals to measure antimicrobial prescribing and resistance worldwide. We aimed to assess antimicrobial prescribing and resistance in hospital inpatients. Methods: We used a standardised surveillance method to collect detailed data about antimicrobial prescribing and resistance from hospitals worldwide, which were grouped by UN region. The internet-based survey included all inpatients (adults, children, and neonates) receiving an antimicrobial who were on the ward at 0800 h on one specific day between January and September, 2015. Hospitals were classified as primary, secondary, tertiary (including infectious diseases hospitals), and paediatric hospitals. Five main ward types were defined: medical wards, surgical wards, intensive-care units, haematology oncology wards, and medical transplantation (bone marrow or solid transplants) wards. Data recorded included patient characteristics, antimicrobials received, diagnosis, therapeutic indication according to predefined lists, and markers of prescribing quality (eg, whether a stop or review date were recorded, and whether local prescribing guidelines existed and were adhered to). We report findings for adult inpatients. Findings: The Global-PPS for 2015 included adult data from 303 hospitals in 53 countries, including eight lowermiddle-income and 17 upper-middle-income countries. 86 776 inpatients were admitted to 3315 adult wards, of whom 29 891 (34·4%) received at least one antimicrobial. 41 213 antimicrobial prescriptions were issued, of which 36 792 (89·3%) were antibacterial agents for systemic use. The top three antibiotics prescribed worldwide were penicillins with β-lactamase inhibitors, third-generation cephalosporins, and fluoroquinolones. Carbapenems were most frequently prescribed in Latin America and west and central Asia. Of patients who received at least one antimicrobial, 5926 (19·8%) received a targeted antibacterial treatment for systemic use, and 1769 (5·9%) received a treatment targeting at least one multidrug-resistant organism. The frequency of health-care-associated infections was highest in Latin America (1518 [11·9%]) and east and south Asia (5363 [10·1%]). Overall, the reason for treatment was recorded in 31 694 (76·9%) of antimicrobial prescriptions, and a stop or review date in 15 778 (38·3%). Local antibiotic guidelines were missing for 7050 (19·2%) of the 36 792 antibiotic prescriptions, and guideline compliance was 77·4%. Interpretation: The Global-PPS showed that worldwide surveillance can be accomplished with voluntary participation. It provided quantifiable measures to assess and compare the quantity and quality of antibiotic prescribing and resistance in hospital patients worldwide. These data will help to improve the quality of antibiotic prescribing through education and practice changes, particularly in low-income and middle-income countries that have no tools to monitor antibiotic prescribing in hospitals., peer-reviewed
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23. ENCEPHALOCELE AND SKELETAL MALFORMATIONS (CASE REPORT).
- Author
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Ghonghadze, T., Lekiashvili, M., Gogatishvili, T., and Pagava, K.
- Published
- 2011
24. A CASE OF DiGEORGE SYNDROME IN GEORGIA.
- Author
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Chikovani M., Kutubidze, T., Khvedeliani, N., and Pagava, K.
- Published
- 2011
25. PURPOSEFULNESS OF USING FUZZY LOGIC APPROACHES IN THE RARE DISEASE CLINICAL TRIALS.
- Author
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Kiseliova, T., Pagava, K., Korinteli, I., Korinteli, M., and Shonvadze, D.
- Published
- 2011
26. UNIVERSITY CENTER ON RARE DISEASES, AS A SUCCESSFUL EXAMPLE OF THE INTEGRATION OF THE CLINICAL SECTOR INTO THE SYSTEM OF MEDICAL EDUCATION.
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Vadachkoria, Z., Abesadze, G., Pagava, K., and Korinteli, I.
- Published
- 2011
27. RARE DISEASES EPIDEMIOLOGY, 2010 (BOOK REVIEW).
- Author
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Pagava, K. and Paghava, I.
- Published
- 2011
28. "INTERNATIONAL CONFERENCE ON RARE DISEASES IN TBILISI, 2010.".
- Author
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Pagava, K. and Paghava, I.
- Published
- 2011
29. EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria
- Author
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Nicolino Ruperto, Riva Brik, Antonella Buoncompagni, Claudia Sengler, Silvia Pederzoli, Ximena Norambuena, Laura Nuño, Dimitrina Mihaylova, Vyacheslav Chasnyk, Djamal Djeddi, Amparo Ibanez Estrella, Mauricio Alegria, Maria Odete Esteves Hilário, Alexandre Belot, Flavio Sztajnbok, Silvia M. Iusan, Jürgen Brunner, Alma Nunzia Olivieri, Yackov Berkun, Alberto Martini, Ilmay Bilge, Luciana Breda, I. Rumba, Calin Lazar, Donato Rigante, Lana Tambic-Bukovac, Luca Cantarini, Clovis A. Silva, Angela Pistorio, Karaman Pagava, Seza Ozen, MG Alpigiani, Yosef Uziel, Aysin Bakkaloglu, Chris Pruunsild, Sulaiman M. Al-Mayouf, Troels Herlin, Maria Klein-Gitelman, Anuela Kondi, Hacettepe Univ, IRCCS G Gaslini, PRINTO, Aarhus Univ Hosp, Rambam Med Ctr, Clin Pediat 1, Istanbul Univ, Meir Med Ctr, Univ Cattolica Sacro Cuore, Med Clin & Sci Immunol Ist, Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP), Hosp Ninos Benjamin Bloom, Hosp Dr Exequiel Gonzalez Cortes, Hop Femme Mere Enfant, Safra Childrens Hosp, Inst Salud Nino, Univ Naples 2, IRCCS Ist G Gaslini, Latvian State Univ, Hosp Univ Pedro Ernesto, Univ Zagreb, Univ G dAnnunzio, King Faisal Specialist Hosp & Res Ctr, Univ Children Hosp, Hosp Paediat Dept, Charite, Childrens Mem Hosp, Dept Pediat, Hosp Gen Univ La Paz, Tartu Univ Hosp, Med Univ, Tblisi State Med Univ, Univ Genoa, Ozen, S., Pistorio, A., Iusan, S., Bakkaloglu, A., Herlin, T., Brik, R., Buoncompagni, A., Lazar, C., Bilge, I., Uziel, Y., Rigante, D., Cantarini, L., Hilario, M., Silva, C., Alegria, M., Norambuena, X., Belot, A., Berkun, Y., Estrella, A., Olivieri, Alma Nunzia, Alpigiani, M., Rumba, I., Sztajnbok, F., TAMBIC BUKOVAC, L., Breda, L., AL MAYOUF, S., Mihaylova, D., Chasnyk, V., Sengler, C., KLEIN GITELMAN, M., Djeddi, D., Nuno, L., Pruunsild, C., Brunner, J., Kondi, A., Pagava, K., Pederzoli, S., Martini, A., Ruperto, N., and Çocuk Sağlığı ve Hastalıkları
- Subjects
Genetics and Molecular Biology (all) ,myalgia ,Vasculitis ,medicine.medical_specialty ,Henoch-Schonlein purpura ,Adolescent ,IgA Vasculitis ,Classification criteria ,International Cooperation ,Immunology ,childhood polyarteritis nodosa ,Biochemistry ,General Biochemistry, Genetics and Molecular Biology ,Rheumatology ,hemic and lymphatic diseases ,Terminology as Topic ,Schoenlein-Henoch ,medicine ,Humans ,Immunology and Allergy ,cardiovascular diseases ,Arteritis ,Child ,Purpura ,c-Wegener granulomatosis ,Epidemiologic Methods ,Granulomatosis with Polyangiitis ,Polyarteritis Nodosa ,Purpura, Schoenlein-Henoch ,Takayasu Arteritis ,Biochemistry, Genetics and Molecular Biology (all) ,criteria ,children ,Henoch-Schönlein purpura ,Wegener granulomatosis ,Takayasu arteritis ,EULAR ,PRINTO ,PRES ,Polyarteritis nodosa ,business.industry ,medicine.disease ,Dermatology ,Surgery ,IgA vasculitis ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,medicine.symptom ,Granulomatosis with polyangiitis ,business ,Rheumatism ,c-Takayasu arteriti - Abstract
EULAR/PRINTO/PRES Objectives To validate the previously proposed classification criteria for Henoch-Schonlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA).Methods Step 1: retrospective/prospective webdata collection for children with HSP, c-PAN, c-WG and c-TA with age at diagnosis
- Published
- 2010
30. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004
- Author
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S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. 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Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
- Subjects
0303 health sciences ,medicine.medical_specialty ,business.industry ,EASD ,Endocrinology, Diabetes and Metabolism ,Human physiology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Family medicine ,Internal Medicine ,Medicine ,business ,030217 neurology & neurosurgery ,030304 developmental biology - Published
- 2004
31. Care of patients with inborn errors of immunity in thirty J Project countries between 2004 and 2021.
- Author
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Abolhassani H, Avcin T, Bahceciler N, Balashov D, Bata Z, Bataneant M, Belevtsev M, Bernatowska E, Bidló J, Blazsó P, Boisson B, Bolkov M, Bondarenko A, Boyarchuk O, Bundschu A, Casanova JL, Chernishova L, Ciznar P, Csürke I, Erdős M, Farkas H, Fomina DS, Galal N, Goda V, Guner SN, Hauser P, Ilyina NI, Iremadze T, Iritsyan S, Ismaili-Jaha V, Jesenak M, Kelecic J, Keles S, Kindle G, Kondratenko IV, Kostyuchenko L, Kovzel E, Kriván G, Kuli-Lito G, Kumánovics G, Kurjane N, Latysheva EA, Latysheva TV, Lázár I, Markelj G, Markovic M, Maródi L, Mammadova V, Medvecz M, Miltner N, Mironska K, Modell F, Modell V, Mosdósi B, Mukhina AA, Murdjeva M, Műzes G, Nabieva U, Nasrullayeva G, Naumova E, Nagy K, Onozó B, Orozbekova B, Pac M, Pagava K, Pampura AN, Pasic S, Petrosyan M, Petrovic G, Pocek L, Prodeus AP, Reisli I, Ress K, Rezaei N, Rodina YA, Rumyantsev AG, Sciuca S, Sediva A, Serban M, Sharapova S, Shcherbina A, Sitkauskiene B, Snimshchikova I, Spahiu-Konjusha S, Szolnoky M, Szűcs G, Toplak N, Tóth B, Tsyvkina G, Tuzankina I, Vlasova E, and Volokha A
- Subjects
- Infant, Newborn, Humans, Administration, Intravenous, Educational Status, Egypt, Europe, Immunoglobulin G
- Abstract
Introduction: The J Project (JP) physician education and clinical research collaboration program was started in 2004 and includes by now 32 countries mostly in Eastern and Central Europe (ECE). Until the end of 2021, 344 inborn errors of immunity (IEI)-focused meetings were organized by the JP to raise awareness and facilitate the diagnosis and treatment of patients with IEI., Results: In this study, meeting profiles and major diagnostic and treatment parameters were studied. JP center leaders reported patients' data from 30 countries representing a total population of 506 567 565. Two countries reported patients from JP centers (Konya, Turkey and Cairo University, Egypt). Diagnostic criteria were based on the 2020 update of classification by the IUIS Expert Committee on IEI. The number of JP meetings increased from 6 per year in 2004 and 2005 to 44 and 63 in 2020 and 2021, respectively. The cumulative number of meetings per country varied from 1 to 59 in various countries reflecting partly but not entirely the population of the respective countries. Altogether, 24,879 patients were reported giving an average prevalence of 4.9. Most of the patients had predominantly antibody deficiency (46,32%) followed by patients with combined immunodeficiencies (14.3%). The percentages of patients with bone marrow failure and phenocopies of IEI were less than 1 each. The number of patients was remarkably higher that those reported to the ESID Registry in 13 countries. Immunoglobulin (IgG) substitution was provided to 7,572 patients (5,693 intravenously) and 1,480 patients received hematopoietic stem cell therapy (HSCT). Searching for basic diagnostic parameters revealed the availability of immunochemistry and flow cytometry in 27 and 28 countries, respectively, and targeted gene sequencing and new generation sequencing was available in 21 and 18 countries. The number of IEI centers and experts in the field were 260 and 690, respectively. We found high correlation between the number of IEI centers and patients treated with intravenous IgG (IVIG) (correlation coefficient, cc, 0,916) and with those who were treated with HSCT (cc, 0,905). Similar correlation was found when the number of experts was compared with those treated with HSCT. However, the number of patients treated with subcutaneous Ig (SCIG) only slightly correlated with the number of experts (cc, 0,489) and no correlation was found between the number of centers and patients on SCIG (cc, 0,174)., Conclusions: 1) this is the first study describing major diagnostic and treatment parameters of IEI care in countries of the JP; 2) the data suggest that the JP had tremendous impact on the development of IEI care in ECE; 3) our data help to define major future targets of JP activity in various countries; 4) we suggest that the number of IEI centers and IEI experts closely correlate to the most important treatment parameters; 5) we propose that specialist education among medical professionals plays pivotal role in increasing levels of diagnostics and adequate care of this vulnerable and still highly neglected patient population; 6) this study also provides the basis for further analysis of more specific aspects of IEI care including genetic diagnostics, disease specific prevalence, newborn screening and professional collaboration in JP countries., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Abolhassani, Avcin, Bahceciler, Balashov, Bata, Bataneant, Belevtsev, Bernatowska, Bidló, Blazsó, Boisson, Bolkov, Bondarenko, Boyarchuk, Bundschu, Casanova, Chernishova, Ciznar, Csürke, Erdős, Farkas, Fomina, Galal, Goda, Guner, Hauser, Ilyina, Iremadze, Iritsyan, Ismaili-Jaha, Jesenak, Kelecic, Keles, Kindle, Kondratenko, Kostyuchenko, Kovzel, Kriván, Kuli-Lito, Kumánovics, Kurjane, Latysheva, Latysheva, Lázár, Markelj, Markovic, Maródi, Mammadova, Medvecz, Miltner, Mironska, Modell, Modell, Mosdósi, Mukhina, Murdjeva, Műzes, Nabieva, Nasrullayeva, Naumova, Nagy, Onozó, Orozbekova, Pac, Pagava, Pampura, Pasic, Petrosyan, Petrovic, Pocek, Prodeus, Reisli, Ress, Rezaei, Rodina, Rumyantsev, Sciuca, Sediva, Serban, Sharapova, Shcherbina, Sitkauskiene, Snimshchikova, Spahiu-Konjusha, Szolnoky, Szűcs, Toplak, Tóth, Tsyvkina, Tuzankina, Vlasova and Volokha.)
- Published
- 2022
- Full Text
- View/download PDF
32. ALPHA- AND BETA-GLOBIN GENE MUTATIONS IN GEORGIA AND ARMENIA.
- Author
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Oberkanins C, Pagava K, Babikyan D, Korinteli IA, Phagava H, Hayrapetian H, Kriegshäuser G, and Sarkisian T
- Subjects
- Armenia epidemiology, Georgia (Republic) epidemiology, Humans, Mutation, beta-Globins genetics, Thalassemia
- Abstract
Georgia and Armenia are situated at the northern rim of the thalassemia belt and bordering to countries with a known high prevalence of thalassemias. In this study we assessed the carrier frequency and potential spectrum of alpha- and beta-globin mutations among 202 and 190 unselected Georgian and Armenian subjects, respectively. We found four alpha-globin mutations (-3.7del, -4.2del, anti-3.7 triplication, poly-A2) in 9 Armenians (4.74%) and 4 Georgians (1.78%). The heterozygous beta-globin codon 8 [-AA] mutation was detected in one individual from Armenia only. Overall, carrier frequencies seem to be low in both countries, supporting the notion that thalassemias are not a major health problem there.
- Published
- 2021
33. [PHYSICAL DEVELOPMENT OF CHILDREN IN ORPHANAGES].
- Author
-
Kalatozishvili P, Davituliani N, Phagava H, Beridze V, and Pagava K
- Subjects
- Body Height, Body Mass Index, Body Weight, Child, Child, Preschool, Female, Humans, Infant, Male, Orphanages, Child Development
- Abstract
Aim - to define the parameters of physical development of children in orphanages. 72 children (45 boys, 27 girls) without chronic debilitating diseases and condition aged from 1 to 6 years from Tbilisi and Makhinjauri orphanages (Georgia) were assessed. Height and weight of all subjects were measured and BMI, height SDS (standard deviation score) and weight SDS were calculated. Data were compared to the normal values (national data). The retardation of the physical development were seen along almost all findings. The significant differences regarding age and gender were not revealed. The most expressed tendency to delay was expressed in the height of boys, particularly aged 3-5 years. Our data confirm that institution upbringing has a negative impact on the growth of children of 1-6 years of age. In children aged from 1 to 6 years who are healthy but live in orphanages there is a marked tendency to lag behind in physical development, mainly in height. The above-mentioned confirms the opinion about negative impact of upbringing in orphanages on the physical development of children.
- Published
- 2016
34. Assessment of anthropological, physical and functional indices in sportsmen (basketball players) against the background of high physical loading.
- Author
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Chakhunashvili G, Jobava N, Guchashvili M, Chakhunashvili K, Gogilashvili T, Shvangiradze M, and Pagava K
- Subjects
- Adolescent, Child, Humans, Male, Anthropometry, Athletic Performance physiology, Basketball physiology, Cardiovascular Physiological Phenomena, Exercise physiology
- Abstract
The goal of the investigation was the estimation of functional condition of anthropometrical, physical and cardiovascular system of sportsmen-basketball players against the background of high physical loading. 100 basketball players at the age from 12 till 18 years underlay the study. Randomized and open controllable research was carried out during 6 months. The following characteristics have been studied: how many days the sportsman is training in a week, how many hours the sportsman is training per day, his mood after training, over fatigue and overtension, frequency of heartbeat, time of breath holding, the general condition, the height in sitting and standing position; circumference of lumbus, chest, arm and limbs, the pulse, pulse, systolic and diastolic arterial pressure before and after physical loading. According to these factors the following sport indices are calculated: Index of Rufe (physical work capacity), the coefficient of endurance (Kvas formula), Shtange test (breath holding at sighing), Genchi test (breath holding at exhalation), average arterial pressure, systolic and cardiac output of blood circulation (the formula of Lilienstrad and Tsander), the coefficient of blood circulation effectiveness, Ketle index (the ratio of height and weight), Minuvre index (the ratio of body and feet length), Pinie index (power of body-build). Statistically authentic increase of breath and pulse in frequency was observed in sportsmen-basketball players after physical loading. The study of amplitude parameters of cardiac cycle among sportsmen-basketball players before and after physical loading has revealed the ability of rather low adaptation of cardiovascular system to physical loading.
- Published
- 2011
35. [What happens when the child gets bacteriophage per os?].
- Author
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Pagava KI, Gachechiladze KK, Korinteli IA, Dzuliashvili MG, Alavidze ZI, Hoyle N, and Metskhvarishvili GD
- Subjects
- Administration, Oral, Adolescent, Age Factors, Antibodies, Neutralizing blood, Antibodies, Viral immunology, Bacterial Infections immunology, Child, Child, Preschool, Combined Modality Therapy, Female, Humans, Infant, Infant, Newborn, Male, Pneumonia, Bacterial immunology, Pneumonia, Bacterial therapy, Sepsis immunology, Sepsis therapy, Urinary Tract Infections immunology, Urinary Tract Infections therapy, Bacterial Infections therapy, Bacteriophages, Biological Therapy methods
- Abstract
The aim of the work was to define the distribution of phages administered per os to children for medical reasons, and the immune response. 102 children aged from 5 days to 15 years with different diseases of bacterial etiology (pneumonia, sepsis, urinary infection, pharyngitis/sinusitis, enteral infection) were monitored. Pyobacteriophage was being included into the complex therapy. The drug was administered per os. In 6/7 of blood, 48/55 urine and 64/75 stool samples taken on the 3-5th day of treatment different components of pyobacteriophage were revealed. The titers varied from 103 to 105 pfu/ml. No age differences were seen. In two weeks after the onset of the phagotherapy the antibodies to phages were tested in the blood serum using the neutralization reaction method. The blood samples were taken from 31 patients. In 14 of them the antibodies neutralizing 52.5-97.3% of the phage activity were seen. A significant age-related peculiarity was determined: in newborns and infants the antibodies were not revealed or their activity was low. Obtained results confirm the reasonability to use of peroral phagotherapy in gastro-intestinal infections. At the same time it was ascertained that the phages taken per os can permeate into the internal environment of the organism and thus the peroral phagotherapy can be used to treat systemic infections and urinary tract infections as well. Absence or low production of the antiphage antibodies in newborns and infants suggests high efficacy of the phagotherapy in this age group.
- Published
- 2011
36. [Blood biochemical changes in maternally deprived children and their emotional status].
- Author
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Gogberashvili KIa, Gagoshidze MV, and Pagava KI
- Subjects
- Anxiety blood, Child, Child, Preschool, Dopamine blood, Humans, Infant, Norepinephrine blood, Orphanages, Serotonin blood, Emotions physiology, Interpersonal Relations, Maternal Deprivation, Stress, Psychological blood
- Abstract
Environmental rearing conditions during the neonatal period are critical for the establishment of neurobiological factors controlling behavior and stress responsiveness. Early maternal deprivation in animals consisting of a single 24-h maternal deprivation episode during early neonatal life has been proposed as an animal model for certain psychopathologies including anxiety, depression and schizophrenic-related disorders. The aim of the present research was to show the mechanisms how the early maternal deprivation in humans influences the emotional status of children. To understand the effects of early deprivation on the regulation of the hypothalamic-pituitary-adrenal axis of children following social interactions, we examined the blood neurotransmitters levels (Norepinefrin NA; Dofamin DF; Serotonin SE) in a group of healthy institutionalized children at age from 6 to 36 months from Tbilisi Infant's House. A group of healthy children of the same age from Mother & child shelters formed the control group. Emotional status was assessed by Leusher's Color Test in a group of healthy institutionalized children at age from 3 to 6 years from Tskneti Orphanage. Institutionalized children showed elevations in blood NE and decreased SE and DF concentrations in comparison with non deprived children's blood. The higher was percentage of children with high level of anxiety in the group of children from orphanage than in the children with family care. The results suggest that early maternal deprivation may contribute to long-term regulatory problems of the stress-responsive system that may be resulted in altered emotionality and behavior in deprived children.
- Published
- 2011
37. [Characteristics of heart rate variability in healthy adolescents and male adults].
- Author
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Chkauseli NN, Tabidze GA, Kvachadze ID, Tsibadze AD, and Pagava KI
- Subjects
- Adolescent, Blood Pressure physiology, Electrocardiography, Humans, Male, Respiration, Young Adult, Heart Rate physiology
- Abstract
The primary purpose of the present article is to investigate the comparative characteristics of heart rate variability in healthy adolescents and male adults. The study was carried out on 41 male adolescents aged 15-16 years and 73 male adults aged 18-22 years. For assessment of heart rate variability statistical data of variability and spectral analysis of heart rate were estimated. Achieved results have proved once again that vegetative balance in healthy individuals is not identical that can be explained by various physiological processes of adolescent age. Such start conditions probably may affect the character of body response to different stimulative impacts. The study suggests that adults tend to have the prevalence of sympatic regular mechanisms whereas in mature age the cases of individuals with the balanced vegetative nervous system in quiescent mode without pathologies are much more frequent.
- Published
- 2011
38. [The congenital parcial erithroblastopenia--Diamond-Blackfan anemia].
- Author
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Kvazireli-Kopadze MA, Pagava KI, and Korinteli IA
- Subjects
- Child, Child, Preschool, Erythrocyte Count, Female, Humans, Infant, Male, Young Adult, Anemia, Diamond-Blackfan pathology, Erythroblasts pathology
- Abstract
The article presents twenty-five year observation on 5 patients with Diamond-Blackfan anemia. In 2010 the new case of this pathology in neonate was diagnosed. Research suggests that rarely, the Diamond-Blackfan anemia may be may be the result of an aplastic anemia. To find out what the real cause of anemia is the number of reticulocytes and qualitative and quantitative indicators bone marrow should be investigated in newborns and infants.
- Published
- 2011
39. [University center on rare diseases, as a successful example of the integration of the clinical sector into the system of medical education].
- Author
-
Vadachkoriia ZO, Abesadze GG, Pagava KI, and Korinteli IA
- Subjects
- Georgia (Republic) epidemiology, Humans, Rare Diseases epidemiology, Academic Medical Centers organization & administration, Education, Medical, Rare Diseases diagnosis, Rare Diseases therapy
- Abstract
There is substantiated appropriateness of the establishment of the University Center on Rare Diseases. It is indicated that the center could illustrate a successful integration of the clinical sector into the system of medical education. The model of the functioning of center and its regulations are presented. The main topics of the special teaching module on rare diseases for physicians are submitted as well.
- Published
- 2011
40. [Purposefulness of using fuzzy logic approaches in the rare disease clinical trials].
- Author
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Kiseleva TS, Pagava KI, Korinteli IA, Korinteli MG, and Shonvadze DN
- Subjects
- Bayes Theorem, Data Interpretation, Statistical, Humans, Clinical Trials as Topic statistics & numerical data, Fuzzy Logic, Rare Diseases therapy
- Abstract
Different methods being used in the rare diseases clinical trials are examined. There is shown the purposefulness of using fuzzy approaches for such studies. Some advantages of Fuzzy logic methods in comparison with Baysian approach are substantiated.
- Published
- 2011
41. New approach to estimate different drugs and/or other medical interventions effectiveness based on fuzzy logic principles.
- Author
-
Pagava K and Kiseleva T
- Subjects
- Humans, Drug Therapy methods, Drug Therapy statistics & numerical data, Fuzzy Logic, Health Services standards, Health Services statistics & numerical data
- Abstract
A new approach for the evaluation of the efficacy of drugs and/or other medical interventions is proposed. It is based on the principles of fuzzy logic, particularly on fuzzy sets, fuzzy cluster analysis and fuzzy expert system.
- Published
- 2008
42. The international conference "German-Georgian collaboration in the field of biomedical sciences".
- Author
-
Pagava K, Witte H, and Kachukhashvili G
- Subjects
- Humans, Biological Science Disciplines, Biomedical Research
- Published
- 2007
43. [Fever of Unknown Origin in children and adolescents in Georgia: a review of 52 patients].
- Author
-
Bakashvili LZ, Makhviladze MA, Pagava EK, and Pagava KI
- Subjects
- Adolescent, Biomarkers analysis, Child, Child, Preschool, Female, Georgia (Republic), Hematologic Tests, Humans, Infant, Male, Fever of Unknown Origin diagnosis, Fever of Unknown Origin etiology
- Abstract
The distribution of the disorders causing Fever of Unknown Origin (FUO) may differ according to the geographic area and the socioeconomic status of the country. FUO has not been appropriately investigated in children and adolescents in Georgia and therefore a study was undertaken to determine its causes and clinical characteristics. A total of 52 children fitting the classical FUO criteria seen in our clinic between 2003 and 2005 were investigated retrospectively. 27 (51,9 %) were boys and 25 (48,0%) were girls. 3 children (5,7 %) were less than 3 years old, 4 (7,6%) were 3-9 years old, 14 (26,9 %) were 10-14 years old and 32 (61,5%) were 15-18 years old. The mean age was 15,9 +/-4,8 years (range 1 year-18 years). 25 children (48,0 %) had a prolonged fever that had lasted for 15-30 days, 15 (28.8 %) for 31-60 days, and 12 (23.0 %) had fever lasting for more than 60 days. The most common causes of FUO were sepsis (10/52), tuberculosis (9/52), pneumonia (8/52), pyelonephritis (5/52), collagen tissue disorder (2/52), neoplasm (2/52), and miscellaneous (9/52). In 7 (13,4 %) of the cases the etiology could not be found. Some derivative hematological parameters--leukocytic index of intoxication, organism's allergisation index, ratios lymphocytes/neutrophils and eosinophils/lymphocytes and adaptation reactions can be helpful to distinguish severe infections. Precise evaluation of hematological changes can be useful for differential diagnosis of FUO. The most common cause of FUO in children and adolescents in Georgia remains infection.
- Published
- 2006
44. Substance abuse among adolescents in Georgia.
- Author
-
Phagava H, Bakashvili I, Chanturishvili T, Abashidze G, and Pagava K
- Subjects
- Adolescent, Female, Georgia (Republic) epidemiology, Humans, Male, Surveys and Questionnaires, Substance-Related Disorders epidemiology
- Abstract
To estimate the substance abuse and thus assess the basic indicators of health risk behavior of the adolescents in Georgia: frequencies of their tobacco, alcohol and drugs consumption. A self-administered anonymous questionnaire was adapted from the Swiss Survey (SMASH2002), translated into Georgian and other languages mainly used in schools (Russian, Armenian and Azeri). It contained 87 questions. Two-stage cluster sampling was devised. Weight was adjusted. A total of 599 classes were selected. Field work took place in 2004. All questionnaires (n=9499; 56,8% filled out by girls, 39,6% - by boys; the mean age was 15,5+/-1,1 years) before being processed into the Epidata were edited. The final data were analysed by SPSS 11.0. 10,4% of adolescents have reported to smoke. The average age of starting to smoke is 13,4 years. 61,2% girls and 67.8% boys drink vine. 56,7% out of the total number of respondents claimed to have been never drunk, 30,0% - answered positively. 2,3% said that they had intravenous drug injection. The drug of preference is cannabis - 6,8%. 72,2% of those who have had intravenous drug injections answered positively to the question "Have you ever been really drunk?" Performed survey is a first one done among adolescents in Georgia. It gave us basic information for planning and implementation of necessary measures in order to improve the health of adolescents and raise awareness of professionals involved in health care and prevention settings for adolescents.
- Published
- 2006
45. [Clinical characteristics of juvenile systemic hypertension in the population of Tbilisi].
- Author
-
Chkuaseli NN, Tsinamdzgarishvili BV, Pagava EK, Tsibadze AD, and Pagava KI
- Subjects
- Adolescent, Catchment Area, Health, Georgia (Republic), Humans, Male, Hypertension epidemiology
- Abstract
The goal of the work was to study a prevalence of juvenile systemic hypertension among 15-16 years old adolescents of Tbilisi, its clinical characteristics and several indices of mental capacity. In the result of an analysis of 378 adolescents' blood pressure records only 6 (1.6%) had high normal values and 32 (8,46%) revealed juvenile systemic hypertension. Four youths from 6 with high normal values refused to participate in a further investigation. For this reason the study was continued only in 32 youths with juvenile systemic hypertension. In the contingent noted 6 (18,75%) had overweight, 9 (28,12%) had hereditary predisposition, 15 (46,9%) revealed excessive use of salt, 3 (9,4%) had moderate consumption of alcohol and 7 (21,9%) noted insufficient physical activity. Juvenile systemic hypertension in youth was predominantly asymptomatic, only 9 (28,12%) had mild headache in the evening, 12 (37,5%) had light fatigue and 5 (15,6%) weak dizziness. Fourteen youths noted diminished work-status and being behind in learning process. In the persons with juvenile systemic hypertension diminution of the attention concentration was observed during a fulfilment of a simple sensor and motor task in condition of monotonous work (increment of answers missed up to 13+/-12%). A psycho-emotional loading test has proved the fact of mental capacity lowering within the persons with juvenile systemic hypertension that is expressed in the increment of errors made up to 12+/-3,1% and answers missed up to 11+/-2,3%. Our investigations confirm the reasonability of blood pressure monitoring among adolescents for the early detection of the juvenile systemic hypertension and the conduction of an opportune preventive measures for avoiding of cardiovascular diseases in a mature age.
- Published
- 2006
46. Adolescents health in Georgia: a national portrait.
- Author
-
Pagava K, Michaud PA, Phagava H, Jeannin A, and Abashidze G
- Subjects
- Adolescent, Female, Georgia (Republic), Health Surveys, Humans, Male, Retrospective Studies, Health Status Indicators, Life Style
- Abstract
The aim of the study was to assess the basic indicators of health of adolescents in Georgia. A self-administered anonymous questionnaire was adapted from the Swiss Survey (SMASH2002), translated into Georgian and other languages mainly used in schools (Russian, Armenian and Azeri). It contained 87 questions. Two-stage cluster sampling was devised. Weight was adjusted. A total of 599 classes were selected. All questionnaires before being processed into the Epidata (www.epidata.dk) were edited. The final data were analysed by SPSS 11.0. General health status was considered as excellent and very good by 34.0+/-0.8% of respondents. 21.5% claimed to never miss the school due to the illness. The frequencies of physical disability and chronic diseases were 8.0% and 5.0% correspondingly. Among health-related problems the most frequent are problems with teeth, headache and acne. 5.9% of girls had some kind of gynecological problems quite often and very often. Performed survey is a first one done among adolescents in Georgia. It gave us basic information for planning and implementation of necessary measures in order to improve the health of adolescents and raise awareness of professionals involved in health care and prevention settings for adolescents. The data can be also used for monitoring of health status of adolescents in Georgia.
- Published
- 2006
47. [Visceral leishmaniasis: clinical and epidemiological features among children and adolescents in Georgia].
- Author
-
Zenanishvili OP, Bakashvili LZ, Pagava EK, Mandzhagaladze MR, and Pagava KI
- Subjects
- Adolescent, Child, Female, Georgia (Republic) epidemiology, Humans, Male, Abdominal Pain epidemiology, Diarrhea epidemiology, Leishmaniasis, Visceral epidemiology, Leishmaniasis, Visceral parasitology, Lymphadenitis epidemiology, Nutrition Disorders epidemiology
- Abstract
The aim of the study was to describe the clinical and epidemiological features of children and adolescents with visceral leishmaniasis in Georgia. We performed a retrospective analysis of demographic, clinical and laboratory data from children and adolescents under age of 18 (n=200) with visceral leishmaniasis admitted to the referral center -- Tbilisi S. Virsaladze Institute of Parasitology between 2000 and 2005. Diagnosis was based on detection of amastigotes in the bone marrow punctate. Age ranged from 4 months to 15.9 years, the average age was 2.79+/-0.17 years. There were 84 girls and 116 boys. 190 cases came from Eastern Georgia (123 from the capital), 10 cases -- from Western Georgia. The period between manifestation of first clinical signs of the disease and admission to the referral center varied from 1 week to 1 year (6.8+/-0,6 weeks in average). Main clinical and laboratory presentations were splenomegaly and hepatomagaly, anemia, pancytopenia (84.5%). Among associated diseases, the most frequent were bronchitis and pneumonia (7.0%) and jaundice (3.5%). In all patients glucantime was used for treatment. One patient died. Visceral leishmaniasis can be considered as an important etiological agent of the fever of unknown origin in Georgia, particularly in Eastern Georgia and in children under six. Health care workers should be trained for the early recognition and appropriate management of visceral leishmaniasis and its complications.
- Published
- 2005
48. Pediatric gastroenterological summer school in Tbilisi, Georgia.
- Author
-
Pagava K, Lentze M, and Kolacek S
- Subjects
- Georgia (Republic), Humans, Academic Medical Centers, Gastroenterology organization & administration, Pediatrics organization & administration
- Published
- 2005
49. Health-related interests of Georgian adolescents.
- Author
-
Bouche M, Simonia G, Phagava H, Tabidze N, and Pagava K
- Subjects
- Adolescent, Child, Female, Georgia (Republic), Humans, Male, Surveys and Questionnaires, Adolescent Behavior, Attitude to Health
- Abstract
The aim of the study was to find out what adolescents in Georgia would like to know about health. Pupils of 6-10 grades (11-17 years old) (n=524) of the focus schools (secondary schools where FRESH program is being implemented) were investigated. A method of participatory research (so called social anthropologic approach) was applied. The study was anonymous. It yielded 3756 questions in total. The questions dedicated to health-related issues made up 36.8% for group I (11-13y.o.), 45,75% for group II (14-17y.o.), 40.5% -- total. The interest in different somatic and psychological problems and diseases was the same in both age groups (14,3%). Interest in sexual items was higher in later adolescents (group I -- 10.58+/-0.66%, group II -- 14.97+/-0.90%, p<0.05). Girls have shown more interest in diseases and common medical problems (M -- 27.3+/-3.2%, F - 45.2+/-2.6%; p<0.05). Boys were more interested in sexual behavior (M -- 40.2+/-3.6%, F -- 25.2+/-2.3%; p<0.05). There was shown a purposefullness of applied research methodology.
- Published
- 2005
50. Application of narrative method to the study of adolescent sexuality.
- Author
-
Kuznecova M, Phagava H, and Pagava K
- Subjects
- Adolescent, Communication, Female, Humans, Male, Narration, Sexual Behavior physiology
- Abstract
Sexual life is one of the most important health-related behaviors of adolescents. WHO has proposed the Narrative Research Method, a way to identify adolescents' sexuality as seen by themselves. The aim of the study was to apply the narrative method as a new research method in order to reveal the level of adolescents' knowledge about sexual life and their attitude to it in Georgia. Two groups of adolescents have been investigated. First group (n=69, age 14-16) consisted of students of secondary school in Tkibuli, second group (n=58, age 17-19) -- of students of the Tbilisi State Medical University College. 81.8% of the total number of respondents think that the couple should have some physical intimacy "within the limits"; sexual relationships before marriage were acceptable to 49.6%; in case of unexpected pregnancy or STD almost 50% would have addressed parents; in case of pregnancy 28% would have consider abortion and 55% -- marriage. The study was a pilot one. It has shown the advisability of the narrative research method as an effective approach to the investigation of adolescents sexuality especially in countries where the direct questions are not acceptable because of different reasons.
- Published
- 2005
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