Search

Your search keyword '"P. Malighetti"' showing total 30 results
Start Over Author "P. Malighetti" Search Limiters Full Text
30 results on '"P. Malighetti"'

1. Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma

Author

Villa, Matteo, Sharma, Geeta G., Malighetti, Federica, Mauri, Mario, Arosio, Giulia, Cordani, Nicoletta, Lobello, Cosimo, Larose, Hugo, Pirola, Alessandra, D’Aliberti, Deborah, Massimino, Luca, Criscuolo, Lucrezia, Pagani, Lisa, Chinello, Clizia, Mastini, Cristina, Fontana, Diletta, Bombelli, Silvia, Meneveri, Raffaella, Lovisa, Federica, Mussolin, Lara, Janikova, Andrea, Pospíšilová, Šárka, Turner, Suzanne D., Inghirami, Giorgio, Magni, Fulvio, Urso, Mario, Pagni, Fabio, Ramazzotti, Daniele, Piazza, Rocco, Chiarle, Roberto, Gambacorti-Passerini, Carlo, and Mologni, Luca

Published
2024
Full Text
View/download PDF

7. Utility of the Khorana and the new-Vienna CATS prediction scores in cancer patients of the HYPERCAN cohort

Author

Verzeroli, Cristina, Giaccherini, Cinzia, Russo, Laura, Bolognini, Silvia, Gamba, Sara, Tartari, Carmen J., Schieppati, Francesca, Ticozzi, Chiara, Vignoli, Alfonso, Masci, Giovanna, Sarmiento, Roberta, Spinelli, Daniele, Malighetti, Paolo, Tondini, Carlo, Petrelli, Fausto, Giuliani, Francesco, D’Alessio, Andrea, Gasparini, Giampietro, Minelli, Mauro, De Braud, Filippo, Santoro, Armando, Labianca, Roberto, Marchetti, Marina, Falanga, Anna, Marina, Marchetti, Silvia, Bolognini, Sara, Gamba, Cinzia, Giaccherini, Laura, Russo, Francesca, Schieppati, Julia, Tartari Carmen, Chiara, Ticozzi, Cristina, Verzeroli, Alfonso, Vignoli, Armando, Santoro, Giovanna, Masci, Filippo, De Braud, Antonia, Martinetti, Carlo, Tondini, Roberto, Labianca, Giampietro, Gasparini, Roberta, Sarmiento, Elisabetta, Gennaro, Mauro, Minelli, Sandro, Barni, Fausto, Petrelli, Mara, Ghilardi, Andrea, D’Alessio, Sara, Cecchini, Francesco, Giuliani, Paolo, Malighetti, Chiara, Morlotti, Daniele, Spinelli, and Falanga, Anna

Abstract

Risk assessment models (RAMs) are relevant approaches to identify cancer outpatients at high risk of venous thromboembolism (VTE). Among the proposed RAMs, the Khorana (KRS) and the new-Vienna CATS risk scores have been externally validated in ambulatory patients with cancer.

Published
2023
Full Text
View/download PDF

10. A grid-based evolutionary spatial algorithm for airline service design in multi-airport systems

Author

Cattaneo, Mattia, Birolini, Sebastian, Malighetti, Paolo, and Paleari, Stefano

Abstract

This paper proposes an integrated modeling framework to support airline frequency planning in a multi-airport system. First, a grid-based spatial model is developed to estimate passenger demand as a function of air-service characteristics (such as flight frequency and airfare) and ground accessibility. Second, an evolutionary algorithm is proposed to provide decision support for the allocation of flights to airports belonging to the multi-airport system, subject to fleet availability, flow balance and operational requirements. We apply the proposed approach to model frequent flyer passengers departing from one of the major multi-airport systems in Europe. Our results show that the degree of diversification of a multi-airport system—i.e., the presence of alternative airports—plays a significant role on both the demand and supply sides, providing passengers with more diversified and accessible services and providing airlines with higher operational flexibility and resilience in case of disruptions. Our modeling framework can be extended to capture additional managerial objectives or practical requirements.

Published
2022
Full Text
View/download PDF

11. Thrombin generation predicts early recurrence in breast cancer patients

Author

Marchetti, Marina, Giaccherini, Cinzia, Masci, Giovanna, Verzeroli, Cristina, Russo, Laura, Celio, Luigi, Sarmiento, Roberta, Gamba, Sara, Tartari, Carmen J., Diani, Erika, Vignoli, Alfonso, Malighetti, Paolo, Spinelli, Daniele, Kuderer, Nicole M., Nichetti, Federico, Minelli, Mauro, Tondini, Carlo, Barni, Sandro, Giuliani, Francesco, Petrelli, Fausto, D’Alessio, Andrea, Gasparini, Giampietro, Labianca, Roberto, Santoro, Armando, De Braud, Filippo, Falanga, Anna, Schieppati, Francesca, Martinetti, Antonia, Gennaro, Elisabetta, and Ghilardi, Mara

Abstract

Cancer patients present with a hypercoagulable state often associated with poor disease prognosis.

Published
2020
Full Text
View/download PDF

12. Hb Monza: A novel extensive HBB duplication with preserved α-β subunit interaction and unstable hemoglobin phenotype

Author

Civettini, Ivan, Zappaterra, Arianna, Corti, Paola, Messina, Amedeo, Aroldi, Andrea, Biondi, Andrea, Cavalca, Fabrizio, Crippa, Valentina, Crosti, Francesca, Ferrari, Giulia Maria, Malighetti, Federica, Mologni, Luca, Piperno, Alberto, Ramazzotti, Daniele, Scollo, Chiara, Zambon, Alfonso, Rossi, Fabio, and Gambacorti-Passerini, Carlo

Abstract

Unstable hemoglobins are caused by single amino acid substitutions in the HBB gene, often affecting key histidine residues, leading to protein destabilization and hemolytic crises. In contrast, long HBB variants, exceeding 20 bp, are rare and associated with a β-thalassemia phenotype due to disrupted α-β chain interactions. We describe a family wherein four of six members carry a novel 23-amino-acid in-frame duplication of HBB (c.176_244dup), named hemoglobin (Hb) Monza. Despite its length, this duplication manifests as an unstable hemoglobin variant rather than a β-thalassemia phenotype.

Published
2024
Full Text
View/download PDF

13. Biallelic PI4KAmutations Disrupt B Cell Mitochondrial Metabolism and Cause Hypogammaglobulinemia

Author

Saettini, Francesco, Guerra, Fabiola, Mauri, Mario, Fazio, Grazia, Bugarin, Cristina, Quadri, Manuel, Rebellato, Stefano, Chinello, Clizia, Pagani, Lisa, Malighetti, Federica, González Gutiérrez-Solana, Luis, Denti, Vanna, Emam Mousavi, Fatemeh, Raspall-Chaure, Miquell, Andrea, Martin-Nalda, Barredo, Estibaliz, Adams, David, Melanie, O'Leary, D'Souza, Precilla, Macnamara, Ellen, Rosenzweig, Sergio, Kuehn, Hye Sun, Stoddard, Jennifer, Mefford, Heather C, Mandrile, Giorgia, Pavinato, Lisa, Brusco, Alfredo, Velez Santamaria, Patricia Valentina, Pujol, Aurora, Michaud, Vincent, Roubertie, Agathe, Nelson, Zoe, Adam, Margaret P, Lo, Bernice, Uhlig, Holm, Salter, Claire G, Baple, Emma, Crosby, Andrew H, Bhatia, Sanil, Magni, Fulvio, Paglia, Giuseppe, Cazzaniga, Giovanni, Piazza, Rocco, Biondi, Andrea, and Barberis, Matteo

Abstract

Introduction

Published
2023
Full Text
View/download PDF

15. Evolution of the European network and implications for self-connection.

Author

Cattaneo, Mattia, Malighetti, Paolo, Paleari, Stefano, and Redondi, Renato

Subjects
COMMERCIAL aeronautics, AIR travelers, AIR travel, LOW cost airlines, AIRPORTS, BUSINESS expansion
Abstract

Self-connection has become an appealing alternative for passengers in the European air transportation market, along with the remarkable growth of the low-cost carriers (LCCs) network over the last decade. As the development of self-connectivity is not directly designed in airports and airlines' growth strategies, this study aims to deeply understand the evolution of self-connectivity options in the intra-European market over time. By implementing a quickest travel time approach, we analyse the number of quickest connections and the share of indirect quickest paths that remained un-managed in years 2006 and 2016. Results document that, overall, travelling in Europe has become faster (−5.7 min of weighted average), while European airports' coverage, that is, airport pairs that can be directly or indirectly connected, decreased from 65% to 53%. The strong increase in LCCs' seat capacity (74%) did not translate into a similar growth of indirect connections options. Due to LCCs' offer redistribution and traditional carriers' partial retreatment from the European market to concentrate on intercontinental destinations, 1-transfer managed or un-managed options available to passengers in Europe dropped by 9.5%, and the share of 1-transfer quickest paths achievable by self-connecting flights increased by only 3pp, from 66% in 2006 to 69% in 2016. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

16. Prefabrication as Large-scale Efficient Strategy for the Energy Retrofit of the Housing Stock: An Italian Case Study.

Author

Pittau, Francesco, Malighetti, Laura E., Iannaccone, Giuliana, and Masera, Gabriele

Subjects
PRECAST concrete construction, PRESERVATION of architecture, ENERGY consumption, INSULATING materials, STRUCTURAL frames
Abstract

In this work a multi-story residential building located in Cinisello Balsamo, near Milan, was considered as case study for the application of two new prefabricated building systems for the energy retrofit. The first one, developed within EASEE, a European project funded by 7 th Framework Program, consists in a preassembled insulated panel for the retrofit of facades, based on two TRC thin precast layers rigidly connected to an EPS core. The panels can be easily applied on the external side of existing facades without the use of scaffoldings, providing an additional efficient insulation as well a new external cladding. The second one consists in a preassembled timber panel for existing pitched roofs. The process includes the substitution of the existing roof with modular integrated panels with a high content of recycled materials that can be easily fixed on the existing structures (timber frames, concrete, masonry, etc.). The combination of the two prefabricated construction systems, applied on the case study, allowed the reduction of the building energy demand by 82%. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

17. Base abandonments by low-cost carriers.

Author

Malighetti, Paolo, Paleari, Stefano, and Redondi, Renato

Subjects
BUSINESS airplanes, LOW cost airlines, AIRPORTS, AIRLINE industry, DOWNSIZING of organizations
Abstract

This paper is the first attempt to systematically investigate the phenomenon of base abandonments by low-cost carriers (LCCs) in the world, from 1997 to 2014. Our results identify 109 cases where the LCCs decreased their presence in airports by at least 50 per cent in terms of offered seats. In 28 cases, the LCCs completely abandoned the airports. The incidence of downsizing is significantly reduced for important base airports. The abandonment by LCCs can be reversed, even though this is not very likely; in only 7.3 per cent of cases the same LCCs recovered full capacity. The impact on airports of LCC abandonments depends on the carrier level of dominance. The presence of middle size alternative airports increases the likelihood of downsizings. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

18. Quantity price discrimination in the air transport industry: The easyJet case.

Author

Cattaneo, Mattia, Malighetti, Paolo, Morlotti, Chiara, and Redondi, Renato

Subjects
COMMERCIAL aeronautics, PRICE discrimination, SINGLE consumers, MULTIVARIATE analysis
Abstract

This paper extends the literature on low-cost carriers' pricing strategies by investigating the presence of quantity price discrimination implemented through a two-part tariff in offered fares. By analysing Internet fares for all easyJet flights departing from the Amsterdam Schiphol airport between March and April 2015, we search for price differentials based on the number of seats booked by a single consumer. We find that the lowest average unit price is associated with a single consumer reserving 5 seats. On average, the per-seat discount for a single consumer reserving 5 seats is €9.48, which is 14% of the single-seat fare. Additionally, a multivariate analysis shows that quantity discounts are greater for flights with a larger fraction of available seats at the time of booking, the seats are booked longer in advance, and the destination's gross domestic product per capita is greater. Conversely, quantity discounts are lower for longer routes, larger destination airports, and routes for which easyJet's market share is higher. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

19. ANTROPOLOGIA PELA EDUCAÇÃO. NOTAS POR UMA DESCOLONIZAÇÃO DO PENSAMENTO.

Author

MALIGHETTI, ROBERTO

Subjects
POLICY sciences, DECOLONIZATION, VIOLENCE, MULTICULTURALISM, CITIZENSHIP
Abstract

Copyright of Educacao & Sociedade is the property of Centro de Estudos de Educacao e Sociedade and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014
Full Text
View/download PDF

20. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two: Genoa, Italy. 28 September – 01 October 2016

Author

Lomakina, Olga, Alekseeva, Ekaterina, Valieva, Sania, Bzarova, Tatiana, Nikishina, Irina, Zholobova, Elena, Rodionovskaya, Svetlana, Kaleda, Maria, Nakagishi, Yasuo, Shimizu, Masaki, Mizuta, Mao, Yachie, Akihiro, Sugita, Yuko, Okamoto, Nami, Shabana, Kousuke, Murata, Takuji, Tamai, Hiroshi, Smith, Eve M., Yin, Peng, Jorgensen, Andrea L., Beresford, Michael W., Eleuteri, Antonio, Goilav, Beatrice, Lewandowski, Laura, Phuti, Angel, Wahezi, Dawn, Rubinstein, Tamar, Jones, Caroline, Newland, Paul, Marks, Stephen, Corkhill, Rachel, Ekdawy, Diana, Pilkington, Clarissa, Tullus, Kjell, Putterman, Chaim, Scott, Chris, Fisher, Antony C., Jorgensen, Andrea, Batu, Ezgi Deniz, Kosukcu, Can, Taskiran, Ekim, Akman, Sema, Ozturk, Kubra, Sozeri, Betul, Unsal, Erbil, Ekinci, Zelal, Bilginer, Yelda, Alikasifoglu, Mehmet, Ozen, Seza, Lythgoe, Hanna, Brunner, Hermine I., Gulati, Gaurav, Jones, Jordan T., Altaye, Mekibib, Eaton, Jamie, Difrancesco, Mark, Yeo, Joo Guan, Leong, Jingyao, Bathi, Loshinidevi D/O Thana, Arkachaisri, Thaschawee, Albani, Salvatore, Abdelrahman, Nagla, Beresford, Michael W, Leone, Valentina, Groot, Noortje, Shaikhani, D., Bultink, I. E. M., Bijl, M., Dolhain, R. J. E. M., Teng, Y. K. O., Zirkzee, E., de Leeuw, K., Fritsch-Stork, R., Kamphuis, S. S. M., Wright, Rachael D., Abdawani, Reem, Al Shaqshi, Laila, Al Zakwani, Ibrahim, Gormezano, Natali W., Kern, David, Pereira, Oriany L., Esteves, Gladys C. C., Sallum, Adriana M., Aikawa, Nadia E., Pereira, Rosa M., Silva, Clovis A., Bonfa, Eloisa, Beckmann, Jessica, Bartholomä, Nora, Venhoff, Nils, Henneke, Philipp, Salzer, Ulrich, Janda, Ales, Boteanu, Alina Lucica, Corral, Sandra Garrote, Giraldo, Alberto Sifuentes, Gámir, Mariluz Gámir, Mendoza, Antonio Zea, Adrovic, Amra, Dedeoglu, Reyhan, Sahin, Sezgin, Barut, Kenan, Koka, Aida, Oztunc, Funda, Kasapcopur, Ozgur, Rodriguez-Lozano, Ana Luisa, Rivas-Larrauri, Francisco, de la Puente, Silvestre García, Alves, Andressa G. F., Giacomin, Maria F. D. A., Farhat, Juliana, Braga, Alfésio L. F., Sallum, Adriana M. E., Campos, Lúcia M. D. A., Pereira, Luiz A. A., Lichtenfels, Ana J. D. F. C., Silva, Clóvis A., Farhat, Sylvia C. L., Acar, Banu, Ozcakar, Z. Birsin, Çakar, Nilgün, Uncu, Nermin, Gür, Gökçe, Özdel, Semanur, Yalçınkaya, Fatoş, Scott, Christiaan, Brice, Nicky, Nourse, Peter, Arango, Christine, Mosquera, Angela C., Malagon, Clara, Sakamoto, Ana P., Silva, Marco F. C. D., Lopes, Ananadreia S., Russo, Gleice C. S., Sallum, Adriana E. M., Kozu, Katia, Bonfá, Eloisa, Saad-Magalhães, Claudia, Pereira, Rosa M. R., Len, Claudio A., Terreri, Maria T., Suri, Deepti, Didel, Siyaram, Rawat, Amit, Singh, Surjit, Maritsi, Despoina, Onoufriou, MArgarita, Vougiouka, Olga, Tsolia, Maria, Bosak, Edi Paleka, Vidović, Mandica, Lamot, Mirta, Lamot, Lovro, Harjaček, Miroslav, Van Nieuwenhove, Erika, Liston, Adrian, Wouters, Carine, Tahghighi, Fatemeh, Ziaee, Vahid, Raeeskarami, Seid-Reza, Aguiar, Francisca, Pereira, Sandra, Rodrigues, Mariana, Moura, Cláudia, Rocha, Gustavo, Guimarães, Hercília, Brito, Iva, Fonseca, Rita, Horneff, Gerd, Klein, Ariane, Minden, Kirsten, Huppertz, Hans-Iko, Weller-Heinemann, Frank, Kuemmerle-Deschner, Jasmin, Haas, J-Peter, Hospach, Anton, Menendez-Castro, Ricardo, Huegle, Boris, Haas, Johannes-Peter, Swart, Joost, Giancane, Gabriella, Bovis, Francesca, Castagnola, Elio, Groll, Andreas, Lovell, Daniel J., Wolfs, Tom, Hofer, Michael, Panaviene, Violeta, Nielsen, Susan, Anton, Jordi, Uettwiller, Florence, Stanevicha, Valda, Trachana, Maria, Marafon, Denise Pires, Ailioaie, Constantin, Tsitsami, Elena, Kamphuis, Sylvia, Herlin, Troels, Doležalová, Pavla, Susic, Gordana, Flatø, Berit, Sztajnbok, Flavio, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Gattorno, Marco, Brucato, Antonio, Finetti, Martina, Lazaros, George, Maestroni, Silvia, Carraro, Mara, Cumetti, Davide, Carobbio, Alessandra, Lorini, Monia, Rimini, Alessandro, Marcolongo, Renzo, Valenti, Anna, Erre, Gian Luca, Belli, Riccardo, Gaita, Fiorenzo, Sormani, Maria Pia, Imazio, Massimo, Abinun, Mario, Smith, Nicola, Rapley, Tim, McErlane, Flora, Kearsley-Fleet, Lianne, Hyrich, Kimme L., Foster, Helen, Tzaribachev, Nikolay, Zeft, Andrew, Cimaz, Rolando, Bohnsack, John, Griffin, Thomas, Carrasco, Ruy, Dare, Jason, Foeldvari, Ivan, Vehe, Richard, Simon, Teresa, Brunner, Hermine, Verazza, S., Davì, S., Consolaro, A., Insalaco, A., Gerloni, V., Cimaz, R., Zulian, F., Pastore, S., Corona, F., Conti, G., Barone, P., Cattalini, M., Cortis, E., Breda, L., Olivieri, A. N., Civino, A., Podda, R., Rigante, D., La Torre, F., D’Angelo, G., Jorini, M., Gallizzi, R., Maggio, M. C., Consolini, R., De Fanti, A., Alpigiani, M. G., Martini, A., Ravelli, A., Kısaarslan, Aysenur Pac, Gunduz, Zubeyde, Dusunsel, Ruhan, Dursun, Ismail, Poyrazoglu, Hakan, Kuchinskaya, Ekaterina, Abduragimova, Farida, Kostik, Mikhail, Sundberg, Erik, Omarsdottir, Soley, Klevenvall, Lena, Erlandsson-Harris, Helena, Basbozkurt, Gokalp, Erdemli, Ozge, Simsek, Dogan, Yazici, Fatih, Karsioglu, Yildirim, Tezcaner, Aysen, Keskin, Dilek, Ozkan, Huseyin, Acikel, Cengizhan, Demirkaya, Erkan, Orbán, Ilonka, Sevcic, Krisztina, Brodszky, Valentin, Kiss, Emese, Tekko, Ismaiel A., Rooney, Madeleine, McElnay, James, Taggart, Cliff, McCarthy, Helen, Donnelly, Ryan F., Slatter, Mary, Nademi, Zohreh, Friswell, Mark, Jandial, Sharmila, Flood, Terence, Hambleton, Sophie, Gennery, Andrew, Cant, Andrew, Duong, Phoi-Ngoc, Koné-Paut, Isabelle, Filocamo, Giovanni, Gamir, María Luz, Sanner, Helga, Carenini, Laura, Topdemir, Mesut, Karslioglu, Yildirim, Gok, Faysal, Tsurikova, Nadezhda, Ligostaeva, Elena, Ramchurn, Navdha R., Kostareva, O., Nikishina, I., Arsenyeva, S., Rodionovskaya, S., Kaleda, M., Alexeev, D., Dursun, Ismail Dursun, Murias, Sara, Barral, Estefania, Alcobendas, Rosa, Enriquez, Eugenia, Remesal, Agustin, de Inocencio, Jaime, Castro, Tania M., Lotufo, Simone A., Freye, Tatjana, Carlomagno, Raffaella, Zumbrunn, Thomas, Bonhoeffer, Jan, Schneider, Elvira Cannizzaro, Kaiser, Daniela, Hofer, Michaël, Hentgen, Véronique, Woerner, Andreas, Schwarz, Tobias, Klotsche, Jens, Niewerth, Martina, Ganser, Gerd, Jeyaratnam, Jerold, ter Haar, Nienke, Rigante, Donato, Dedeoglu, Fatma, Baris, Ezgi, Vastert, Sebastiaan, Frenkel, Joost, Hausmann, Jonathan S., Lomax, Kathleen G., Shapiro, Ari, Durrant, Karen L., Brogan, P. A., Hofer, M., Kuemmerle-Deschner, J. B., Lauwerys, B., Speziale, A., Leon, K., Wei, X., Laxer, R. M., Signa, Sara, Rusmini, Marta, Campione, Elena, Chiesa, Sabrina, Grossi, Alice, Omenetti, Alessia, Caorsi, Roberta, Viglizzo, Gianmaria, Ceccherini, Isabella, Federici, Silvia, Lachmann, Helen, Ruperto, Nicola, Vanoni, Federica, Gomes, Sonia Melo, Omoyinmi, Ebun, Arostegui, Juan I., Gonzalez-Roca, Eva, Eleftheriou, Despina, Klein, Nigel, Brogan, Paul, Volpi, Stefano, Santori, Elettra, Picco, Paolo, Pastorino, Claudia, Rice, Gillian, Tesser, Alessandra, Crow, Yanick, Candotti, Fabio, Sinoplu, Ada B., Yucel, Gozde, Pamuk, Gizem, Damian, Laura O., Lazea, Cecilia, Sparchez, Mihaela, Vele, Paulina, Muntean, Laura, Albu, Adriana, Rednic, Simona, Lazar, Calin, Mendonça, Leonardo O., Pontillo, Alessandra, Kalil, Jorge, Castro, Fabio M., Barros, Myrthes T., Pardeo, Manuela, Messia, Virginia, De Benedetti, Fabrizio, Insalaco, Antonella, Malighetti, Giorgia, Gorio, Chiara, Ricci, Francesca, Parissenti, Ilaria, Montesano, Paola, Bonafini, Barbara, Medeghini, Veronica, Cattalini, Marco, Giordano, Lucio, Zani, Giulia, Ferraro, Rosalba, Vairo, Donatella, Giliani, Silvia, Maggio, Maria Cristina, Luppino, Girolamo, Corsello, Giovanni, Fernandez, Maria Isabel Gonzalez, Montesinos, Berta Lopez, Vidal, Adriana Rodriguez, Gorospe, Juan I. Arostegui, Penades, Inmaculada Calvo, Rafiq, Nadia K., Wynne, Karen, Hussain, Khalid, Brogan, Paul A., Ang, Elizabeth, Ng, Nicholas, Kacar, Ayla, Gucenmez, Ozge Altug, Makay, Balahan, Unsal, Sevket Erbil, Sahin, Yasin, Kutlu, Tufan, Cullu-Cokugras, Fugen, Ayyildiz-Civan, Hasret, Erkan, Tulay, Al Zuhbi, Sana, Abdalla, Eiman, Russo, Ricardo A., Katsicas, María M., Minoia, Francesca, Ravelli, Angelo, Bhattad, Sagar, Gupta, Anju, Pandiarajan, Vignesh, Nada, Ritambhra, Tiewsoh, Kaara, Hawkins, Philip, Rowczenio, Dorota, Fingerhutova, Sarka, Franova, Jana, Prochazkova, Leona, Hlavackova, Eva, Dolezalova, Pavla, Evrengül, Havva, Yüksel, Selçuk, Doğan, Mustafa, Gürses, Dolunay, Evrengül, Harun, De Pauli, Silvia, Pastore, Serena, Bianco, Anna Monica, Severini, Giovanni Maria, Taddio, Andrea, Tommasini, Alberto, Salugina, Svetlana O., Fedorov, Evgeny, Kamenets, Elena, Zaharova, Ekaterina, Sleptsova, Tatiana, Alexeeva, Ekaterina, Savostyanov, Kirill, Pushkov, Alexander, Bzarova, Tatyana, Valieva, Saniya, Denisova, Rina, Isayeva, Kseniya, Chistyakova, Evgeniya, Soloshenko, Margarita, Kaschenko, Elena, Kaneko, Utako, Imai, Chihaya, Saitoh, Akihiko, Teixeira, Vitor A., Ramos, Filipa O., Costa, Manuela, Aviel, Yonatan Butbul, Fahoum, Shafe, Brik, Riva, Özçakar, Zeynep Birsin, Celikel, Banu Acar, Yalcinkaya, Fatos, Schiappapietra, Benedetta, Davi’, Sergio, Mongini, Federica, Giannone, Luisa, Bava, Cecilia, Alpigiani, Maria Giannina, Consolaro, Alessandro, Lazarevic, Dragana S., Vojinovic, Jelena, Basic, Jelena, Muratore, Valentina, Marzetti, Valentina, Quilis, Neus, Benavente, Belen Serrano, Alongi, Alessandra, Civino, Adele, Quartulli, Lorenzo, Januskeviciute, Giedre, van Dijkhuizen, Pieter, Groot, N., van Dijk, W., Kardolus, A., Suárez, Raul Gutiérrez, Nordal, Ellen B., Rypdal, Veronika G., Berntson, Lillemor, Ekelund, Maria, Aalto, Kristiina, Peltoniemi, Suvi, Zak, Marek, Glerup, Mia, Arnstad, Ellen D., Fasth, Anders, Rygg, Marite, Duarte, Ana Catarina, Sousa, Sandra, Teixeira, Lídia, Cordeiro, Ana, Santos, Mª José, Mourão, Ana Filipa, Santos, Maria José, Eusébio, Mónica, Lopes, Ana, Oliveira-Ramos, Filipa, Salgado, Manuel, Estanqueiro, Paula, Melo-Gomes, José, Martins, Fernando, Costa, José, Furtado, Carolina, Figueira, Ricardo, Branco, Jaime C., Fonseca, João E., Canhão, Helena, Mourão, Ana F., Santos, Maria Jose, Coda, Andrea, Cassidy, Samuel, West, Kerry, Hendry, Gordon, Grech, Debra, Jones, Julie, Hawke, Fiona, Grewal, Davinder Singh, Foley, Charlene, Killeen, Orla, MacDermott, Emma, Veale, Douglas, Fearon, Ursula, Konukbay, Dilek, Tarakci, Ela, Arman, Nilay, Şahin, Sezgin, Munro, Jane, Morgan, Esi, Riebschleger, Meredith, Horonjeff, Jennifer, Strand, Vibeke, Bingham, Clifton, Collante, Ma. Theresa M., Ganeva, Margarita, Stefanov, Stefan, Telcharova, Albena, Mihaylova, Dimitrina, Saraeva, Radoslava, Tzveova, Reni, Kaneva, Radka, Tsakova, Adelina, Temelkova, Katya, Picarelli, Maria Mercedes C., Danzmann, Luiz C., Barbé-Tuana, Florencia, Grun, Lucas K., Jones, Marcus H., Frković, Marijan, Ištuk, Karla, Birkić, Ika, Sršen, Saša, Jelušić, Marija, Easton, Alan, Quarmby, Rachael, Khubchandani, Raju, Chan, Mercedes, Srp, Radoslav, Kobrova, Katerina, Nemcova, Dana, Hoza, Jozef, Uher, Michal, Saifridova, Melania, Linkova, Lenka, Charuvanij, Sirirat, Leelayuwattanakul, Isree, Pacharapakornpong, Thita, Vallipakorn, Sakda A.-O., Lerkvaleekul, Butsabong, Vilaiyuk, Soamarat, Lanni, Stefano, Davì, Sergio, Cron, Randy Q., Passarelli, Chiara, Pisaneschi, Elisa, Novelli, Antonio, Bracaglia, Claudia, Caiello, Ivan, de Graaf, Kathy, Guilhot, Florence, Ferlin, Walter, Schulert, Grant, Grom, Alexi A., Nelson, Robert, de Min, Cristina, Holzinger, Dirk, Kessel, Christoph, Fall, Ndate, Grom, Alexei, de Jager, Wilco, Strippoli, Raffaele, Horne, Anna, Ehl, Stephan, Ammann, Sandra, Lehmberg, Kai, Beutel, Karin, Foell, Dirk, Horne, AnnaCarin, Pagani, Laura, Espada, Graciela, Gao, Yi-jin, Shenoi, Susan, Weitzman, Sheila, Prencipe, Giusi, Pascarella, Antonia, Ferlin, Walter G., Chatel, Laurence, Jacqmin, Philippe, De Graaf, Kathy, Ballabio, Maria, Johnson, Zoë, Lapeyre, Geneviève, de Benedetti, Fabrizio, Cristina, de Min, Wakiguchi, Hiroyuki, Hasegawa, Shunji, Hirano, Reiji, Okazaki, Fumiko, Nakamura, Tamaki, Kaneyasu, Hidenobu, Ohga, Shouichi, Yamazaki, Kazuko, Nozawa, Tomo, Kanetaka, Taichi, Ito, Shuichi, Yokota, Shumpei, McLellan, Kirsty, MacGregor, Ishbel, Martin, Neil, Davidson, Joyce, Hansmann, Sandra, Eikelberg, Andreas, Haug, Iris, Schuller, Sabrina, Benseler, Susanne M., Nazarova, Liliia S., Danilko, Kseniia V., Malievsky, Viktor A., Viktorova, Tatiana V., Mauro, Angela, Barnicoat, Angela, Hurst, Jane, Canham, Nathalie, Lacassagne, Sandrine, Wiener, Anastasia, Hügle, Boris, Denecke, Bernd, Costa-Filho, Ivan, Haas, Johannes Peter, Tenbrock, Klaus, Popp, David, Boltjes, Arjan, Rühle, Frank, Herresthal, Stefanie, van Wijk, Femke, Schultze, Joachim, Stoll, Monika, Klotz, Luisa, Vogl, Thomas, Roth, Johannes, Quesada-Masachs, Estefania, de la Sierra, Daniel Álvarez, Prat, Marina Garcia, Sánchez, Ana M. Marín, Borrell, Ricardo Pujol, Barril, Sara Marsal, Gallo, Mónica Martínez, Caballero, Consuelo Modesto, Chyzheuskaya, Iryna, Byelyaeva, Lyudmyla M., Filonovich, Rostislav M., Khrustaleva, Helena K., Zajtseva, Larisa I., Yuraga, Tamara M., Giner, Thomas, Hackl, Lukas, Albrecht, Julia, Würzner, Reinhard, Brunner, Juergen, Minute, Marta, Parentin, Fulvio, Nocerino, Agostino, Nørgaard, Mette, Alberdi-Saugstrup, Mikel, Zak, Marek S., Nielsen, Susan M., Nordal, Ellen, Müller, Klaus G., Avramovič, Mojca Zajc, Dolžan, Vita, Toplak, Nataša, Avčin, Tadej, Ruperto, N., Lovell, D. J., Wallace, C., Toth, M., Foeldvari, I., Bohnsack, J., Milojevic, D., Rabinovich, C., Kingsbury, D., Marzan, K., Quartier, P., Minden, K., Chalom, E., Horneff, G., Kuester, R. M., Dare, J., Heinrich, M., Kupper, H., Kalabic, J., Brunner, H. I., Burgos-Vargas, Ruben, Constantin, Tamas, Dehoorne, Joke, Stanevica, Valda, Kobusinska, Katarzyna, Zuber, Zbigniew, Mouy, Richard, Rumba-Rozenfelde, Ingrida, Job-Deslandre, Chantal, Pederson, Ronald, Bukowski, Jack, Hinnershitz, Tina, Vlahos, Bonnie, Keskitalo, Paula, Kangas, Salla, Vähäsalo, Paula, Valencia, Raul A. Chavez, Martino, David, Ponsonby, Anne-Louise, Chiaroni-Clarke, Rachel, Meyer, Braydon, Allen, Roger C., Akikusa, Jonathan D., Craig, Jeffrey M., Saffrey, Richard, Ellis, Justine A., Wallace, Carol, Uziel, Yosef, Sterba, Gary, Schneider, Rayfel, Russo, Ricardo, Ramanan, Athimalaipet V., Schmid, Jana Pachlopnik, Nichols, Kim E, Miettunen, Paivi, Kitoh, Toshiyuki, Ilowite, Norman T., Henter, Jan-Inge, Grom, Alexei A, Behrens, Edward M., Avcin, Tadej, Aricò, Maurizio, Grevich, Sriharsha, Lee, Peggy, Ringold, Sarah, Leroux, Brian, Leahey, Hannah, Yuasa, Megan, Foster, Jessica, Sokolove, Jeremy, Lahey, Lauren, Robinson, William, Newson, Joshua, Stevens, Anne, Shoop, Stephanie J. W., Verstappen, Suzanne M. M., Thomson, Wendy, McDonagh, Janet E., Beukelman, Timothy, Kimura, Yuki, Natter, Marc, Ilowite, Norm, Mieszkalski, Kelly, Burrell, Grendel, Best, Brian, Bristow, Helen, Carr, Shannon, Dennos, Anne, Kaufmann, Rachel, Schanberg, Laura, Simonini, Gabriele, Lancini, Francesca, Gerbaux, Margaux, Lê, Phu-Quoc, Goffin, Laurence, Badot, Valérie, La, Céline, Caspers, Laure, Willermain, François, Ferster, Alina, Ceci, Maria, Licciardi, Francesco, Turco, Marco, Santarelli, Francesca, Montin, Davide, Toppino, Claudia, Alizzi, Clotilde, Papia, Bruno, Vergara, Beatrice, Corpora, Umberto, Messina, Luca, Tsinti, Maria, Dermentzoglou, Vasiliko, Tziavas, Panagiotis, Perica, Marija, Bukovac, Lana Tambić, Çakan, Mustafa, Ayaz, Nuray Aktay, Keskindemirci, Gonca, Lang, Michael, Laing, Catherine, Benseler, Susanne, Gerschman, Tommy, Luca, Nadia, Schmeling, Heinrike, Dropol, Anastasia, Taiani, Jaymi, Johnson, Nicole, Rusted, Brian, Nalbanti, Panagiota, Pratsidou, Polyxeni, Pardalos, Grigoris, Tzimouli, Vasiliki, Taparkou, Anna, Stavrakidou, Maria, Papachristou, Fotios, Kanakoudi-Tsakalidou, Florence, Bale, Peter, Robinson, Emily, Palman, Jason, Ralph, Elizabeth, Gilmour, Kimberly, Heard, Clare, Wedderburn, Lucy R., Barrense-Dias, Yara, Gregory, Antonarakis, Amira, Dhouib, Paolo, Scolozzi, Sylviane, Hanquinet, Michaël, Hofer, Panko, Nataliya, Shokry, Salah, Rakovska, Liudmila, Pino, Sally, Diaz-Maldonado, Adriana, Guarnizo, Pilar, Torreggiani, Sofia, Cressoni, Paolo, Garagiola, Umberto, Di Landro, Giancarla, Farronato, Giampietro, Corona, Fabrizia, Bell, Samantha, Bhatti, Parveen, Nelson, Lee, Mueller, Beth A., Simon, T. A., Baheti, A., Ray, N., Guo, Z., Hazra, Anasuya, Stock, Thomas, Wang, Ronnie, Mebus, Charles, Alvey, Christine, Lamba, Manisha, Krishnaswami, Sriram, Conte, Umberto, Wang, Min, Kingsbury, Daniel, Koskova, Elena, Smolewska, Elzbieta, Vehe, Richard K., Lovell, Daniel, Kubota, Tomohiro, Yasumura, Junko, Kizawa, Toshitaka, Yashiro, Masato, Yamatou, Tsuyoshi, Yamasaki, Yuichi, Takei, Syuji, Kawano, Yoshifumi, Nykvist, Ulrika Järpemo, Magnusson, Bo, Wicksell, Rikard, Palmblad, Karin, Olsson, Gunnar L., Modaressi, Mohammadreza, Moradinejad, Mohammad-Hassan, Seraya, Valentina, Vitebskaya, Alisa, Moshe, Veronica, Amarilyo, Gil, Harel, Liora, Hashkes, Phillip J, Mendelson, Amir, Rabinowicz, Noa, Reis, Yonit, Dāvidsone, Zane, Lazareva, Arina, Šantere, Ruta, Bērziņa, Dace, Staņēviča, Valda, Varnier, Giulia Camilla, Maillard, Susan, Ferrari, Cristina, Zaffarano, Silvia, Wienke, Judith, Enders, Felicitas Bellutti, van den Hoogen, Lucas L., Mertens, Jorre S., Radstake, Timothy R., Hotten, Henny G., Fritsch, Ruth, Wedderburn, Lucy, Nistala, Kiran, Prakken, Berent, van Royen-Kerkhof, Annet, Alhemairi, Mohammad, Muzaffer, Mohammed, Van Dijkhuizen, Pieter, Deakin, Claire T., Simou, Stefania, De Iorio, Maria, Wu, Qiong, Amin, Tania, Dossetter, Lee, Campanilho-Marques, Raquel, Deakin, Claire, Pilkington, Clarissa A., Rosina, Silvia, Soponkanaporn, Sirisucha, Arıcı, Zehra S., Tuğcu, Gökçen D., Batu, Ezgi D., Sönmez, Hafize E., Doğru-Ersöz, Deniz, Talim, Beril, Kiper, Nural, Özen, Seza, Solyom, Alexander, Batu, Ezgi, Mitchell, John, Kariminejad, Ariana, Hadipour, Fatemeh, Hadipour, Zahra, Torcoletti, Marta, Agostoni, Carlo, Di Rocco, Maja, Tanpaiboon, Pranoot, Superti-Furga, Andrea, Bonafé, Luisa, Arslan, Nur, Guelbert, Norberto, Ehlert, Karoline, Grigelioniene, Giedre, Puri, Ratna, Schuchman, Edward, Gomez, Pilar, Gonzalez, Tatiana, Yepez, Ricardo, Vargas, Camilo, Fernanda, Falcini, Lepri, Gemma, Ferrari, Alessandra, Matucci-Cerinic, Marco, Meini, Antonella, Moneta, Gian Marco, Marasco, Emiliano, Nicolai, Rebecca, Bracci-Laudiero, Luisa, Kopchak, Olga, Mushkin, Alexander, Maletin, Alexey, Mosquera, Catalina, Amorim, Rita A., Molina, Juliana, Moreira, Gustavo, Santos, Flávia H., Fraga, Melissa, Keppeke, Livia, Silva, Vanessa M., Hirotsu, Camila, Tufik, Sergio, Terreri, Maria Teresa, Braga, Vinícius L., Fonseca, Maria Beatriz, Schinzel, Vania, Terreri, Maria Teresa R., Jorge, Liliana, Guerra, Liana, Junior, Edson Amaro, Castiglione, Maria Cristina, Tricarico, Alessandra, Boulter, Emily, Schultz, Andre, Murray, Kevin, Falcini, Fernanda, Stagi, Stefano, Bellucci, Eleonora, Grein, Ingrid H. R., Pileggi, Gecilmara, Pinto, Natália B. F., de Oliveira, Aline L., Belyaeva, Lyudmila, Filonovich, Rostislav, Khrustaleva, Helena, Zajtseva, Larisa, Ilisson, Jaanika, Pruunsild, Chris, Gilliaux, Olivier, Corazza, Francis, Lelubre, Christophe, Morel, Zoilo, C, Claudia Saad-Magalhães, Lira, Luis, Ladino, Mabel, Eraso, Ruth, Arroyo, Ivonne, Silva, Clovis, and Rose, Carlos

Published
2017
Full Text
View/download PDF

21. The impact of airport competition on technical efficiency: A stochastic frontier analysis applied to Italian airport.

Author

Scotti, Davide, Malighetti, Paolo, Martini, Gianmaria, and Volta, Nicola

Subjects
COMPETITION in the airline industry, TECHNICAL assistance, COMMERCIAL aeronautics, MONOPOLY capitalism, ECONOMIC competition, AIRPORTS
Abstract

Abstract: We investigate how the intensity of competition among airports affects their technical efficiency by computing airports’ markets on the basis of a potential demand approach. We find that the intensity of competition has a negative impact on airports’ efficiency in Italy from 2005 to 2008. This implies that airports belonging to a local air transportation system where competition is strong exploit their inputs less intensively than do airports with local monopoly power. Further, we find that public airports are more efficient than private and mixed ones. Hence, policy makers should provide incentives to implement airports’ specialization in local systems where competition is strong and monitor the inputs’ utilization rate even when private investors are involved. [Copyright &y& Elsevier]

Published
2012
Full Text
View/download PDF

22. De-hubbing of airports and their recovery patterns.

Author

Redondi, Renato, Malighetti, Paolo, and Paleari, Stefano

Subjects
AIRPORTS, RECOVERY movement, COMMERCIAL aeronautics, LITERARY libraries, DOCUMENT clustering, COST effectiveness
Abstract

Abstract: The paper analyzes cases of de-hubbing in air transport between 1997 and 2009. It initially addresses the conditions to be met for airports to be identified as de-hubbing cases. Second, it examines what happens after de-hubbing by clustering the cases into homogenous groups that show that, on average, airports that experienced de-hubbing did not recover their original traffic within five years and that de-hubbing is likely to be irreversible. When hub carriers were replaced at least partially by low-cost carriers, airports on average recovered faster. De-hubbing adversely affects the number of destinations served less severely than the seats offered by carriers. [Copyright &y& Elsevier]

Published
2012
Full Text
View/download PDF

23. Pricing strategies of low-cost airlines: The Ryanair case study.

Author

Malighetti, Paolo, Paleari, Stefano, and Redondi, Renato

Subjects
AIRLINE rates, PRICING, AIR travel, CASE studies
Abstract

Abstract: We analyse the pricing policy adopted by Ryanair, the main low-cost carrier in Europe. Based on a year''s fare data for all of Ryanair''s European flights, using a family of hyperbolic price functions, the optimal pricing curve for each route is estimated. The analysis shows a positive correlation between the average fare for each route and its length, the frequency of flights operating on that route, and the percentage of fully booked flights. As the share of seats offered by the carrier at the departure and destination airports increases, fares tend to decrease. The correlation of dynamic pricing to route length and the frequency of flights is negative. Conversely, as competition increases discounts on advance fares rise. [Copyright &y& Elsevier]

Published
2009
Full Text
View/download PDF

24. Connectivity of the European airport network: “Self-help hubbing” and business implications.

Author

Malighetti, Paolo, Paleari, Stefano, and Redondi, Renato

Subjects
AIRPORTS, COMMERCIAL aeronautics, AIRLINE industry, AIR travel, TRAVEL time (Traffic engineering)
Abstract

Abstract: This paper investigates the connectivity of the European air transportation network. A time-dependent minimum path approach is employed to calculate the minimum travel time between each pair of airports in the network, inclusive of flight times and waiting times. The connectivity offered by each alliance''s network is compared with that of the overall network. The results show that roughly two-thirds of the fastest indirect connections are not operated by the alliance system; this could be exploited to enable a new passenger strategy of “self-help hubbing”. [Copyright &y& Elsevier]

Published
2008
Full Text
View/download PDF

25. EU-US Open Skies Agreement: What Is Changed in the North Transatlantic Skies?

Author

Morandi, Valentina, Malighetti, Paolo, Paleari, Stefano, and Redondi, Renato

Abstract

This article presents analysis of air service levels and competition dynamics in the transatlantic market before and after the EU-US Open Skies Agreement (OSA) signed in 2008. By comparing direct and connecting flights in a typical off-peak week, we investigate whether the EU-US OSA has led to more choices for transatlantic travelers. We examine the impact of the EU-US OSA on competition between carriers, alliances, and hub airports. The results show that the number of direct transatlantic connections and served airport pairs decreased and only indirect competition increased.

Published
2014
Full Text
View/download PDF

26. A tale of airline competition: When full-service carriers undercut low-cost carriers fares.

Author

Avogadro, Nicolò, Malighetti, Paolo, Redondi, Renato, and Salanti, Andrea

Subjects
FARES, AIRLINE routes, AIRLINE industry, AIRLINE rates, TIME-based pricing, PRODUCT differentiation
Abstract

The pricing of low-cost carriers (LCCs) compared with traditional airlines has been extensively investigated since their inception in the air transport market. Abundant empirical evidence attests that, on average , LCCs' fares (per km) are lower than those usually offered by full-service carriers (FSCs). Such literature, however, paid virtually no attention to the conditions under which LCCs lose their convenience compared to traditional airlines. The purpose of this study is to investigate the occurrence of LCCs sometimes offering higher fares than FSCs on competing flights. By using a dataset expressly collected for this purpose, we are able to quantify its frequency and suggest some possible explanations. These findings concur to cast some questions on the widely held preconception of vertical differentiation between LCCs' and FSCs' offered services. Further research will be needed in order to understand the relative weight of the suggested factors. • The article analyses the cases in which LCCs offer higher fares than FSCs on competing flights. • The phenomenon is more likely when approaching the date of the flight. • "Price reversal" is related to passengers' search habits and airlines' reputations. • The phenomenon is more frequent on routes connecting multi-airport cities. • We identify the typical price interactions between LCCs and FSCs leading to the phenomenon. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

27. Thrombotic Risk Assessment in a Prospective Cohort of Newly Diagnosed Ambulatory Cancer Patients Candidate to Chemotherapy

Author

Falanga, Anna, Verzeroli, Cristina, Marchetti, Marina, Giaccherini, Cinzia, Russo, Laura, Masci, Giovanna, Celio, Luigi, Sarmiento, Roberta, Gamba, Sara, Tartari, Carmen J, Diani, Erika, Vignoli, Alfonso, Malighetti, Paolo, Spinelli, Daniele, Tondini, Carlo, Barni, Sandro, Giuliani, Francesco, Petrelli, Fausto, D'Alessio, Andrea, Gasparini, Giampietro, De Braud, Filippo, Santoro, Armando, and Labianca, Roberto

Abstract

Santoro: Eisai: Consultancy, Speakers Bureau; Novartis: Speakers Bureau; MSD: Speakers Bureau; Servier: Consultancy, Speakers Bureau; Pfizer: Consultancy, Speakers Bureau; BMS: Consultancy; Abb-Vie: Speakers Bureau; Roche: Speakers Bureau; Bayer: Consultancy, Speakers Bureau; AstraZeneca: Speakers Bureau; BMS: Speakers Bureau; Amgen: Speakers Bureau; Celgene: Speakers Bureau; Lilly: Speakers Bureau; Arqule: Consultancy, Speakers Bureau; Gilead: Consultancy, Speakers Bureau; Sandoz: Speakers Bureau; Takeda: Speakers Bureau.

Published
2019
Full Text
View/download PDF

28. A Thrombotic Biomarker-Based Risk Assessment Scoring Model for Disease Recurrence in Breast Cancer Patient Candidate to Systemic Chemotherapy

Author

Falanga, Anna, Giaccherini, Cinzia, Marchetti, Marina, Masci, Giovanna, Verzeroli, Cristina, Russo, Laura, Celio, Luigi, Sarmiento, Roberta, Gamba, Sara, Tartari, Carmen J, Diani, Erika, Vignoli, Alfonso, Malighetti, Paolo, Spinelli, Daniele, Tondini, Carlo, Barni, Sandro, Giuliani, Francesco, Petrelli, Fausto, D'Alessio, Andrea, Gasparini, Giampietro, De Braud, Filippo, Santoro, Armando, and Labianca, Roberto

Abstract

Background. Hypercoagulability, a common finding in cancer patients, is associated with an increased risk of both thrombosis and tumor development. The HYPERCAN study (ClinicalTrials.gov, ID# NCT02622815) is an ongoing Italian prospective, multicenter, observational study, evaluating the predictive value of thrombotic markers for early cancer diagnosis in healthy subjects and for cancer prognosis and venous thromboembolism in patients with newly diagnosed malignant disease. In this analysis of a large cohort of patients with breast cancer, we evaluated whether pre-chemotherapy thrombotic biomarker levels: 1. are associated with breast cancer-specific clinicopathological features; and 2. may predict for disease recurrence (DR).

Published
2019
Full Text
View/download PDF

29. Pre-Chemotherapy Levels of Hemostatic Biomarkers and Prediction of Prognosis in Newly Diagnosed Metastatic Cancer Patients from the Hypercan Study

Author

Falanga, Anna, Giaccherini, Cinzia, Verzeroli, Cristina, Marchetti, Marina, Russo, Laura, Masci, Giovanna, Celio, Luigi, Merelli, Barbara, Sarmiento, Roberta, Ghilardi, Mara, Tartari, Carmen J, Brevi, Shenaz, Caldara, Gloria, Gamba, Sara, Malighetti, Paolo, Spinelli, Daniele, Santoro, Armando, De Braud, Filippo, Gasparini, Giampietro, Giuliani, Francesco, Barni, Sandro, D'Alessio, Andrea, and Labianca, Roberto

Abstract

No relevant conflicts of interest to declare.

Published
2018
Full Text
View/download PDF

30. Thrombotic biomarkers for risk prediction of malignant disease recurrence in patients with early stage breast cancer.

Author

Giaccherini C, Marchetti M, Masci G, Verzeroli C, Russo L, Celio L, Sarmiento R, Gamba S, Tartari CJ, Diani E, Vignoli A, Malighetti P, Spinelli D, Tondini C, Barni S, Giuliani F, Petrelli F, D'Alessio A, Gasparini G, De Braud F, Santoro A, Labianca R, and Falanga A

Subjects
Biomarkers, Biomarkers, Tumor, Humans, Neoplasm Recurrence, Local, Prognosis, Prospective Studies, Breast Neoplasms diagnosis, Breast Neoplasms therapy
Abstract

In cancer patients, hypercoagulability is a common finding. It has been associated with an increased risk of venous thromboembolism, but also to tumor proliferation and progression. In this prospective study of a large cohort of breast cancer patients, we aimed to evaluate whether pre-chemotherapy abnormalities in hemostatic biomarkers levels: (i) are associated with breast cancer-specific clinico-pathological features; and (ii) can predict for disease recurrence. D-dimer, fibrinogen, prothrombin fragment 1+2, and FVIIa/antithrombin levels were measured in 701 early-stage resected breast cancer patients candidate to adjuvant chemotherapy and prospectively enrolled in the HYPERCAN study. Significant prognostic parameters for disease recurrence were identified by Cox regression multivariate analysis and used for generating a risk assessment model. Pre-chemotherapy D-dimer, fibrinogen, and pro-thrombin fragment 1+2 levels were significantly associated with tumor size and lymph node metastasis. After 3.4 years of follow up, 71 patients experienced a recurrence. Cox multivariate analysis identified prothrombin fragment 1+2, tumor size, and Luminal B HER2-negative or triple negative molecular subtypes as independent risk factors for disease recurrence. Based on these variables, we generated a risk assessment model that significantly differentiated patients at low- and high-risk of recurrence (cumulative incidence: 6.2 vs 20.7%; Hazard Ratio=3.5; P <0.001). Our prospective clinical and laboratory data from the HYPERCAN study were crucial for generating a scoring model for assessing risk of disease recurrence in resected breast cancer patients, candidate to systemic chemotherapy. This finding stimulates future investigations addressing the role of plasma prothrombin fragment 1+2 in the management of breast cancer patients to provide the rationale for new therapeutic strategies. (The HYPERCAN study is registered at clinicaltrials.gov identifier 02622815 )., (Copyright© 2020 Ferrata Storti Foundation.)

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results