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1. Evaluation of a photonic lantern spatial demultiplexer based receiver for optical communication

Author

Billault, Vincent, Leviandier, Luc, Bourderionnet, Jerome, Pierre, Christophe, Sanquer, Raynald, Castaing, Marc, and Brignon, Arnaud

Subjects
Physics - Optics
Abstract

In this paper, we present a method based on a modal decomposition to quantify the efficiency of photonic lanterns (PL) based free space optical (FSO) communication receivers. We fabricate a seven port PL and we evaluate numerically the free space to fiber coupling efficiency based on a reconstruction of the fields at the PL FSO multimode port. We validate the numerical approach with an experimental characterization of the PL. Then we compare the PL to a commercial multiplane light converter spatial demultiplexer. The PL shows better coupling efficiency for low order spatial modes with orders of magnitude of demultiplexer size reduction. Finally we evaluate the PL receiver with a simulation of received optical wavefront in a FSO communication

Published
2024

2. Evaluation of a multimode receiver with a photonic integrated combiner for satellite to ground optical communications

Author

Billault, Vincent, Bourderionnet, Jerome, Leviandier, Luc, Feneyrou, Patrick, Maho, Anaelle, Sotom, Michel, and Brignon, Arnaud

Subjects
Electrical Engineering and Systems Science - Signal Processing, Physics - Optics
Abstract

Multimode receivers based on spatial or modal diversity are promising architectures to mitigate in real time the atmospheric turbulence effects for free space optical (FSO) communications. In this paper, we evaluate and comment on the dynamical communication performances of a FSO mode diversity receiver, based on a spatial demultiplexer and a silicon photonic coherent combiner, for an optical link from a GEO satellite to an optical ground station (OGS). We simulate time series of distorted wavefronts received by the OGS and we show numerically that the coherent combination of spatial modes mitigate the signal fading compared to a conventional single mode fiber (SMF) receiver. We verify this property in a laboratory environment by generating the wavefronts corresponding to the use case with an atmospheric propagation channel emulator. Then we modulate the optical carrier prior to the wavefront emulator with 10G OOK and DPSK data sequences to measure the BER performance of the proposed receiver during the time series emulation. Finally, we study and comment on the influence of the number of modes combined and the wavelength multiplexing on the BER performances. We prove that the mode diversity receiver provide a higher collection efficiency, has better BER performances and much less synchronization losses., Comment: 8 pages, 9 figures

Published
2022

3. Free space optical communication receiver based on a spatial demultiplexer and a photonic integrated coherent combining circuit

Author

Billault, Vincent, Bourderionnet, Jerome, Mazellier, Jean-Paul, Leviandier, Luc, Feneyrou, Patrick, Maho, Anaelle, Sotom, Michel, Normandin, Xavier, Lonjaret, Herve, and Brignon, Arnaud

Subjects
Physics - Applied Physics, Physics - Optics
Abstract

Atmospheric turbulences can generate scintillation or beam wandering phenomena that impairs free space optical (FSO) communication. In this paper, we propose and demonstrate a proof-of-concept FSO communication receiver based on a spatial demultiplexer and a photonic integrated circuit coherent combiner. The system collects the light from several Hermite Gauss spatial modes and coherently combine on chip the energy from the different modes into a single output. The FSO receiver is characterized with a wavefront emulator bench that generates arbitrary phase and intensity patterns. The multimode receiver presents a strong resilience to wavefront distortions, compared to a monomode FSO receiver. The system is then used to detect a modulation of the optical beam through a random wavefront profile., Comment: 8 pages, 7 figures

Published
2021
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5. A risk-based method to prioritize cumulative impacts assessment on marine biodiversity and research policy for offshore wind farms in France.

Author

Brignon, Jean-Marc, Lejart, Morgane, Nexer, Maëlle, Michel, Sylvain, Quentric, Alan, and Thiebaud, Léa

Subjects
MARINE biodiversity, OFFSHORE wind power plants, WIND power
Abstract

This study developed the "ECUME" risk-based approach to identify and prioritize critical impact pathways to be considered in cumulative impact assessment of offshore windfarms, and for future research. The prioritization framework has been tested on two offshore windfarms projects located in the French part of the English Channel off the coast of Normandy, those of Fécamp and Courseulles-sur-Mer. The approach is based on a complete inventory of impact pathways, prioritizing those for which an impact assessment will be carried out. The aim was to avoid a "quantification bias" and elaborate a systemic vision. The novelty of the study is to apply a combination of expert judgement, consensus building, and a scoring system, to prioritize the pairs of pressures and receptors of the marine environment to work on. The scoring system is based on the ecological importance of receptors, the degree of knowledge on the effect of a pressure on a receptor and the sensitivity of each receptor to pressures. Priorities for research were also determined during the same process. Bringing together a large set of specialized marine environnement scientists, the initial challenge was to build a common vocabulary, and a shared understanding of the risk-based prioritization approach. This required significant time and effort but secured foundations for further work. This study confirms the increasingly shared view that adopting a risk-based approach considering adverse effects on receptors is an efficient way to assess cumulative impacts, to focus on critical impact pathways, and manage the scientific complexity and the significant uncertainties. • We prioritize issues in cumulative impact assessment of offshore windfarms. • Prioritization combines risk-based expert judgement and a scoring system. • It is also used to identify priority research areas for the future. • It was tested on two French offshore windfarm projects. • Such a risk-based approach allows to manage scientific complexity and uncertainties. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Posterpräsentation

Author

Erb, N., Dürig, P., Dietz, U., Müller, K., Lachat R., Dietz Th. U., Berger E., Junod M., Schneider H., Gaudin, G., Borgeat, A., Taziari, G., Borgeat, A., Valiton, A., Fahti, M., Rifat, K., Schreyer, A., Maillard-Brignon, C., Vial, Y., Hohlfeld, P., Laurini, R., Pescia, G., Schnegg, A., Leuenberger, E., Dürig, P., Hänngi, W., and Sidiropoulos, D.

Published
1995
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7. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author

Couchoud, Cécile, Bayer, Florian, Ayav, Carole, Béchade, Clémence, Brunet, Philippe, Chantrel, François, Frimat, Luc, Galland, Roula, Hourmant, Maryvonne, Laurain, Emmanuelle, Lobbedez, Thierry, Mercadal, Lucile, Moranne, Olivier, Abbassi, Abdelhamid, Debure, Alain, Guerraoui, Abdallah, Benmoussa, Abdelatif, Hamani, Abdelaziz, Ziane, Abdelaziz, Nefti, Abdelhamid, Hadj, Abdelkader, El Amari, Abderrahim, Ghazali, Abderrahmane, Abd El Fatah Mohamed, Abo Bakr, Laradi, Achour, Ben Ahmed, Adel, Sahar, Adel, Pillet, Adele, Lacraz, Adeline, Moinat, Adnan, Massoumi, Afshin, Pardon, Agathe, Beaudoin, Agnes Caillette, Debout, Agnes Chapelet, Mariot, Agnes, Rachi, Ahmed, Afiani, Aida, Boula, Aime Remy, Jalaby, Al, Cremault, Alain, Fournier, Alain, Jeanson, Alain, Lyon, Alain, Nony, Alain, Robert, Alain, Slingeneyer, Alain, Labatide, Alanor Agnes, Sartorius, Albane Brodin, Bensman, Albert, Fournier, Albert, Ranlin, Alex, Sandor, Alex Vido, Colombo, Alexandra, Duhem, Alexandra, Stancu, Alexandra, Dufay, Alexandre, Dumoulin, Alexandre, Ebel, Alexandre, Klein, Alexandre, Martin, Alexandre, Mouneimne, Alexandre, Seidowsky, Alexandre, De Martin, Alfio, Zannier, Alfredo, Aizel, Ali, Hafi, Ali, Diddaoui, Ali Zineddine, Heyani, Alim, Mocanu, Alina, Preda, Alina, Hafi, Aline, Talaszka, Aline, Duquesne, Alyette, Amaouche, Amar, Ghemmour, Amel, Simon, Amelie, Skalli, Amina, Boukadida, Amine, Ragab Eid, Amr Ekhlas, Fedorca, Ana, Baillet, Anabelle, Poyet, Anais, Giorgita, Ancuta Bouffandeau, Ratsimbazafy, Anderson, Pruna, Andre, Argiles, Angel, Testa, Angelo, Vandooren, Ann Karolien, Jolivot, Anne, Labadens, Anne Kolko, Lataste, Anne, Maisin, Anne, Paris, Anne, Sechet, Anne, Wuillai, Anne, Heng, Anne Elisabeth, Josse, Anne Gaelle, Querard, Anne Helene, Reboux, Anne Helene, Adra, Anne Laure, Faller, Anne Laure, Leclerc, Anne Laure, Poitou, Anne Laure, Manucci, Annie Lahoche, Jacquet, Antoine, Pommereau, Antoine, Thierry, Antoine, Adem, Arezki, Chapelet, Arielle, Del Bello, Arnaud, Delezire, Arnaud, Garnier, Arnaud, Guerard, Arnaud, Klisnick, Arnaud, Lionet, Arnaud, Roccabianca, Arnaud, Stolz, Arnaud, Capdeville, Arthur, Allal, Asma, Alrifai, Assem, Diarrassouba, Assetou, Djema, Assia, Carre, Assia Ferhat, Dubrasquet, Astrid Godron, Elmrabet, Atman Haddj, Jegado, Audrey, Thomas, Aurelia Bertholet, Salandre, Aurelie Davourie, Pajot, Aurelie, Lorthioir, Aurelien, Tiple, Aurelien, Sury, Aurore, Abokasem, Ayman, Sarraj, Ayman, Henaoui, Bachir, Chaghouri, Baher, Wehbe, Bassem, Ball, Beatrice, Viron, Beatrice, Issad, Belkassem, Corne, Benedicte Hodemon, Janbon, Benedicte, Deroure, Benjamin, Savenkoff, Benjamin, Jonon, Benoit, Vendrely, Benoit, Djelaleddine, Benyakoub, Ohry, Bernard, Painchart, Bernard, Strullu, Bernard, Temperville, Bernard, Ebikili, Bertin, Hacq, Bertrand, Morel, Bertrand, Aoun, Bilal, Muniz, Blanca, Chlih, Bouchra, Amara, Brahim, Mayor, Brice, Gilson, Brigitte, Llanas, Brigitte, Zins, Brigitte, Bourgeon, Bruno, Coevoet, Bruno, Guery, Bruno, Legallicier, Bruno, 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Emilie, Kalbacher, Emilie, Pambrun, Emilie, Pincon, Emilie, Launay, Emma Allain, Baron, Emmanuel, Dupuis, Emmanuel, Villar, Emmanuel, Charlin, Emmanuelle, Hecquet, Emmanuelle, Kohler, Emmanuelle, Laurain, Emmanuelle, Rosier, Emmanuelle, Figueroa, Enrique, Azoulay, Eric, Canivet, Eric, Daugas, Eric, Gauthier, Eric, Laruelle, Eric, Le Guen, Eric, Legrand, Eric, Moumas, Eric, Postec, Eric, Prinz, Eric, Renaudineau, Eric, Desport, Estelle, Sutra, Estelle Ricard, Berard, Etienne, Ged, Etienne, Robin, Etienne, Vilaine, Eve, Bargas, Evelyne, Namara, Evelyne Mac, Combarnous, François, Yazbeck, Fatima, Gerard, Fabien, Metivier, Fabien, Parazols, Fabien, Soulis, Fabien, Garnier, Fabrice, Messaoudene, Fadhila Pech, Haidar, Fadi, Boullenger, Fanny, Lepeytre, Fanny, Leroy, Fanny, Frejate, Fares, Bellahsene, Farid, Bellhasene, Farid, Saidani, Farid, Toure, Fatouma, Kriaa, Faycal, Nemmar, Fazia, Vetromile, Fernando, Chalmin, Florence, Lucats, Florence, Sens, Florence, Villemain, Florence, Plasse, Florent, Lebhour, Fouad, Schillinger, Francis, Berge, Franck, Bourdon, Franck, Bridoux, Franck, Reynaud, Franck, Babinet, Francois, Basse, Francois, Chantrel, Francois, Clair, Francois, Coulomb, Francois, De Cornelissen, Francois, Glowacki, Francois, Marchal, Francois, Maurice, Francois, Nobili, Francois, Pourreau, Francois, Provot, Francois, Amani, Francois Roux, Broux, Francoise, Bulte, Francoise, Heibel, Francoise, Leonetti, Francoise, Schott, Francoise Moussion, Le Roy, Frank, Besson, Frederic, Lavainne, Frederic, Tollis, Frederic, Bocquentin, Frederique, Meeus, Frederique, Vecina, Frederique, Von Ey, Friederike, Balit, Gabriel, Choukroun, Gabriel, Gruget, Gabriel, Huchard, Gabriel, Golea, Gabriella, Duneau, Gabrielle, Lefrancois, Gaelle, Pelle, Gaelle, Lebrun, Gaetan, Dumont, Genevieve, Brillet, Georges, Deschenes, Georges, Mourad, Georges, Stamatakis, Georges, Cazajous, Geraldine, D'ythurbide, Geraldine, Wiart, Geraldine Robitaille, Cardon, Gerard, Champion, Gerard, Deschodt, Gerard, Mangenot, Gerard, Motte, Gerard, Schortgen, Gerard, Boulahia, Ghada, Maakaroun, Ghassan, Michel, Ghylene Bourdat, Zanetta, Gilbert, Hufnagel, Gilles, Messier, Gilles, Piccoli, Giorgina, Desvergnes, Gregoire Couvrat, Bobrie, Guillaume, Bonnard, Guillaume, Clement, Guillaume, Jean, Guillaume, Queffeulou, Guillaume, Seret, Guillaume, Vernin, Guillaume, Delavaud, Guy, Lambrey, Guy, Rostoker, Guy, Poussard, Gwenaelle, Kesler, Gwenaelle Roussey, Leon, H., Aboubekr, Habib, Boulechfar, Hacene, Sekhri, Hacene, Hebibi, Hadia, Benalia, Hadjira, Fessi, Hafed, Atchia, Hafsabhai, Bittar, Haiat, Maiza, Hakim, Mazouz, Hakim, El Ali, Hamid, Bougrida, Hammouche, Van Der Pijl, Hans, Lokmane, Hassan, Izzedine, Hassane, Adda, Hassen, De Preneuf, Helene, Leray, Helene, Philippot, Helene, Boulanger, Henri, Merault, Henri, Renaud, Henri, Bonarek, Herve, Maheut, Herve, Nzeyimana, Hilaire, Mehama, Hocine, Zaidi, Hocine, Weclawiak, Hugo, Flodrops, Hugues, Karaaslan, Huseyin, Haskour, Ibrahim, Belhadj, Ihssen, Almoubarak, Imad, Haddad, Imad, Castellano, Ines, Ferrandiz, Ines, Daniliuc, Ioana, Darie, Ioana, Enache, Ioana, Prunescu, Ionut, Djiconkpode, Irenee, Shahapuni, Irina, Bouchoule, Isabelle, Devriendt, Isabelle, Kazes, Isabelle, Kolb, Isabelle, Landru, Isabelle, Poli, Isabelle, Rey, Isabelle, Segalen, Isabelle, Selcer, Isabelle, Vernier, Isabelle, Vrillon, Isabelle, Guenifi, Ismahane, Gheerbrandt, J. Dominique, Potier, Jacky, Becart, Jacques, Cledes, Jacques, Ducros, Jacques, Duvic, Jacques, Fourcade, Jacques, Gaultier, Jacques, Jurine, Jacques, Lebleu, Jacques, Ollier, Jacques, Charles, Jacques Ibsen, Yazji, Jamal, Mansour, Janette, Arnautou, Jean, Brocard, Jean, Carolfi, Jean, Montoriol, Jean, Gouin, Jean Baptiste, Palcoux, Jean Bernard, Bendini, Jean Christophe, Aldigier, Jean Claude, Alphonse, Jean Claude, Delbet, Jean Daniel, Bonne, Jean Francois, Cantin, Jean Francois, De Fremont, Jean Francois, Dessassis, Jean Francois, Subra, Jean Francois, Valentin, Jean Francois, Verdier, Jean Francois, Dion, Jean Jacques, Haultier, Jean Jacques, Montseny, Jean Jacques, Bacri, Jean Louis, Bouchet, Jean Louis, Mahe, Jean Luc, Chalopin, Jean Marc, Gabriel, Jean Marc, Hurot, Jean Marc, Lanau, Jean Marc, Batho, Jean Marie, Coulibaly, Jean Marie, Hardin, Jean Michel, Marc, Jean Michel, Poux, Jean Michel, Rebibou, Jean Michel, Tivollier, Jean Michel, Ottavioli, Jean Noel, Faucon, Jean Paul, Imiela, Jean Paul, Jaulin, Jean Paul, Masselot, Jean Paul, Ortiz, Jean Paul, Bourdenx, Jean Philippe, Devaux, Jean Philippe, Hammelin, Jean Philippe, Rivory, Jean Pierre, Wauquier, Jean Pierre, Larue, Jean Rene, Mondain, Jean Rene, Borde, Jean Sebastien, Virot, Jean Simon, Bosc, Jean Yves, Achiche, Jedjiga, Parasote, Jennifer, Diolez, Jeremie, Harambat, Jerome, Potier, Jerome, Sampol, Jerome, Mustel, Jihad, Lefevre, Jean Jacques, Maurizi, Jocelyne, Gamberoni, Joel, Claudeon, Joelle, Terzic, Joelle, Rogol, Joffrey, Sayegh, Johnny, Cardozo, Jorge, Brasseur, Jose, Guiserix, Jose, Barsumau, Joseph, Albaret, Julie, Beaume, Julie, Attias, Julie Sohier, Dehay, Julien, Hogan, Julien, Journet, Julien, Ott, Julien, Baleynaud, Juliette, Bacchetta, Justine, Faucher, Justine, Yousfi, Kamel, Dardim, Karim, Clabault, Karine, Moreau, Karine, Thomas, Kedna, Sirajedine, Khaled, Chedid, Khalil, El Kaeoui, Khalil, El Karoui, Khalil, Bouachi, Khedidja, Hue, Kheira, El Nasser, Khuzama, Akposso, Kodso, Kunz, Kristian, Bijak, Krzysztof, Kihal, Lilia, Rasoloarijaona, L., Harbouche, Laid, Bencheikh, Larbi, Lamriben, Larbie, Hanafi, Latifa, Parvez, Laura Braun, Champion, Laure, Croze, Laure, Eprinchard, Laure, Patrier, Laure, Nicolet, Laurence, Vrigneaud, Laurence, Duflot, Laurent, Mackaya, Leandre, Chenine, Leila, Odry, Leon, Tamiji, Lili Taghipour, Bouzar, Lilia Antri, Nga Messi, Liliane Ngango, Le Mouellic, Lionel, Mandart, Lise, Weis, Lise, Pouteau, Lise Marie, Georgieva, Lora, Vitanova, Lorita, Chalabi, Lotfi, Delvallez, Luc, Frimat, Luc, Fromentin, Luc, Marty, Luc, Monjot, Luc, Spataru, Luciana, Bessenay, Lucie, Boissinot, Lucie, Wajsbrot, Lucie, Rakoff, Lucien, Lebourg, Ludivine, Perez, Lydie, Lafage, Lyliane, Azzouz, Lynda, Dumoulin, Madeleine, Ouziala, Messaoud, Joseph, Maan, Brahimi, Mabrouk, Fat, Maeva Wong, Fort, Magalie, Nakhla, Magued, Abtahi, Mahdi, Albadawy, Mahen, Alouach, Mahmoud, Mezghani, Mahmoud, Daroux, Maite, Boukelmoune, Maklouf, Dhib, Malek, Touam, Malik, Dubau, Malina, Balde, Mamadou, Khoa, Man Nguyen, Ismer, Manfred, Mehdi, Manolie, Laforet, Manon, Bouiller, Marc, Eugene, Marc, Fila, Marc, Hazzan, Marc, Kribs, Marc, Ladriere, Marc, Lebot, Marc, Padilla, Marc, Souid, Marc, Marraoui, Marcel, Burbach, Maren, Manescu, Maria, Noguera Gonzalez, Maria Eugenia, Revenco, Mariana, Terrasse, Marianne, Essi, Marie, Macher, Marie Alice, Nogier, Marie Beatrice, Cazin, Marie Cecile, Schweitzer Camoin, Marie Christine, Thouret, Marie Christine, Hannaert, Marie Claude, Servel, Marie France, Chabannier, Marie Helene, Coudert Krier, Marie Jeanne, Catoliquot, Marie Noelle, Guillodo, Marie Paule, Gavard, Marie Sophie, Vairon Codaccioni, Marie Xaviere, Rabec, Marina, Freist, Marine, Gauthier, Marion, Lemaire, Marion, Mehrenberger, Marion, Venot, Marion, Pongas, Marios, Diant, Marlene Beaubrun, Levannier, Martial, Bertaux, Martine, Jablonski, Mathieu, Sacquepee, Mathieu, Dargelos, Mathilde, Lemoine, Mathilde, Tamain, Mathilde, Monge, Matthieu, Reberolle, Matthieu, Cousin, Maud, Francois, Maud, Baron, Maurice, Hoffmann, Maxime, Ingwiller, Maxime, Touzot, Maxime, Mohajer, Mederick, Maaz, Mehadji, Hanoy, Melanie, Marroc, Melanie, Cuny, Melodie, Van Der Straaten, Menno, Serveaux, Mf., Basteri, Michel, Chong, Michel Fen, Hecht, Michel, Massad, Michel, Normand, Michel, Olmer, Michel, Tolani, Michel, Tsimaratos, Michel, Hemery, Michele, Kessler, Michele, Esposito, Miguel, Shenouda, Milad, Kareche, Mimi, Khalili, Mina, Diaconita, Mirella, Rifard, Mohamad Khair, Aladib, Mohamed, Belmouaz, Mohamed, Brahim, Mohamed, Diouani, Mohamed, Cherif, Mohamed Fodil, Jamali, Mohamed, Maghlaoua, Mohamed, Meddeb, Mohamed, Ramdane, Mohamed, Rifaat, Mohamed, Islam, Mohamed Sharifull, Abbade, Mohamed Adnan, Amrandi, Mokhtar, Chawki, Mokhtar, Ciobotaru, Monica, Indrieis, Monica, Chanas, Monique, Hoarau, Monique, Tomeh, Monzer, Bellou, Moufida, Bouzernidj, Mouloud, Ammor, Mounia, Guergour, Mounir, Benzakour, Mountassir, Hachicha, Mourad, Coulibaly, Moussa, Smati, Mustafa, Al Morabiti, Mustapha, Amirou, Mustapha, Isnard, Myriam, Pastural, Myriam, Pujo, Myriam, Boumendjel, Nourredine, Majbri, Nabil, Goumri, Nabila, Mingat, Nadege, Bassilios, Nader, Kerkeni, Nadia, Sedrati, Nadia, Soltani, Nadia, Maroun, Nadine, Neyrat, Nadine, Luang, Nahn, El Esper, Najeh, Ammar, Naji, Ghali, Nasredine, Hamdini, Nasser, Noel, Natacha, Potelune, Natacha, Maisonneuve, Nathalie, Pertuiset, Nathalie, Raynal, Nathalie, Vittoz, Nathalie, Terki, Nazim, Castin, Nelly, Nankeu, Nestor, Bouvier, Nicolas, Keller, Nicolas, Legros, Nicolas, Peters, Nicolas, Quirin, Nicolas, Lefrancois, Nicole, Monnier, Nicole, Rance, Nicole, Bruckmann, Niels, Mertens, Noel, Lorcy, Nolwenn, Gilbert, Olivia, Coldefy, Olivier, Drouineau, Olivier, Dunand, Olivier, Fritz, Olivier, Imhoff, Olivier, Kourilsky, Olivier, Lavelle, Olivier, Moranne, Olivier, Papin, Olivier, Roques, Olivier, Le Maner, Ophelie, Benbrahim, Oussamah Fikri, Erina Torres, Pablo Antonio, Urena Torres, Pablo Antonio, Malvezzi, Paolo, Bindi, Pascal, Cluzel, Pascal, Fontanier, Pascal, Wheatley, Pascal, Depraetre, Pascale, Dubosq, Pascale, Halin, Pascale, Sebahoun, Pascale, Siohan, Pascale, Testevuide, Pascale, Deteix, Patrice, Nolen, Patrice, Hue, Patricia, Lemarchand, Patricia, Donnadieu, Patrick, Fievet, Patrick, Fohrer, Patrick, Francais, Patrick, Giraud, Patrick, Hallonet, Patrick, Henri, Patrick, Michaut, Patrick, Michaut, Patrick, Niaudet, Patrick, Pauly, Patrick, Thomas, Patrick, Deleaval, Patrik, Finielz, Paul, Stroumza, Paul, Yverneau, Paule Hardy, Caillard, Pauline, Palacin, Pedro, Aubertin, Perrine, Attias, Philippe, Brunet, Philippe, Chauveau, Philippe, Coindre, Philippe, Coste, Philippe, Dubot, Philippe, Fournier, Philippe, Hiernaux, Philippe, Jousset, Philippe, Yue Wah, Philippe Lan, Lang, Philippe, Le Cacheux, Philippe, Dupont, Philippe Martin, Michel, Philippe, Mirgaine, Philippe, Moriniere, Philippe, Nicoud, Philippe, Rieu, Philippe, Rousseau, Philippe, Sporer, Philippe, Thorel, Philippe, Vanhille, Philippe, Vigeral, Philippe, Zaoui, Philippe, Bataille, Pierre, Brignon, Pierre, Filipozzi, Pierre, Housset, Pierre, Peyronnet, Pierre, Ramperez, Pierre, Vautrin, Pierre, Michel, Pierre Alexandre, Westeel, Pierre Francois, Carron, Pierre Louis, Durand, Pierre Yves, Parent, Pierrot, Seniuta, Piotr, Kuentz, François, Fraoui, Rabah, Tetaz, Rachel, Amaria, Rachid, Bourouma, Rachid, Djeffal, Rachid, Nebbad, Rachida, Allal, Radia, Dimulescu, Radu, Boustani, Rafaat, Mesbah, Rafik, Makdassi, Raifat, Diab, Raji, Puslenghea, Raluca, Roura, Raoul, Khayat, Rateb, Azar, Raymond, Frayssinet, Raymond, Monkam, Regine, Boulahrouz, Rehouni, Boudet, Remi, Demontis, Renato, Gansey, Renaud, Cuvelier, Rene, Schmitt, Renee, Noordally, Reschad, Binaut, Reynald, Latif, Rezkallah, Dufresne, Richard, Montagnac, Richard, Reade, Richard, Genin, Robert, Novo, Robert, Fickl, Rocsana, Dufresne, Roger, Magnol, Roger, Issautier, Roland, Mortelette, Romain, Delaval, Ronan, Lohro, Ronan, M'barga, Roseline, Beau, S., Dupuis, Clémentine, Vidil, Marie Jacques, Hacini, Sabria, Dahmoune, Said, Lekhal, Saliha, Sakso, Salima Ahriz, Saksi, Salima, Citarda, Salvatore, Boubenider, Samir, Kassis, Samuel, Verhille, Sandra, Genestier, Sandrine, Muller, Sandrine, Krid, Saoussen, Richter, Sarah, Delbes, Sebastien, Mailliez, Sebastien, Veillon, Sebastien, Nony, Sébastien, Benarbia, Seddick, Beaudreuil, Severine, Benyaghla, Sidi Ali, Duquennoy, Simon, Baluta, Simona, Boncila, Simona, Mzoughi, Sonia, Ribal, Sonia, Acamer, Sophie, Chauvet, Sophie, Girerd, Sophie, Ozenne, Sophie, Parahy, Sophie, Duval, Sophie Rubens, Taque, Sophie, Menouer, Soraya, Chargui, Soumaya, Bataille, Stanislas, Barbier, Stephane, Billion, Stephane, Roueff, Stephane, Torner, Stephane, Martin, Stephane Jean, Coupel, Stephanie, Cloarec, Sylvie, Lavaud, Sylvie, Leou, Sylvie, Chatelet, T., Onesta, Tania, Benhabib, Tassadit, Bensalem, Tayeb, Dimulescu, Theodora, Sawadogo, Theophile, Hitze, Thibault Dolley, Baranger, Thierry, Boudemaghe, Thierry, Hannedouche, Thierry, Krummel, Thierry, Lobbedez, Thierry, Milcent, Thierry, Dervaux, Thomas, Guincestre, Thomas, Kofman, Thomas, Raphael, Thomas, Sadreux, Thomas, Ulinski, Tim, Roger, Tiphaine Guyon, Serrato, Tomas, Kofman, Tomek, Wong, Tony, Boubia, Toufik, Gbindoun, Ubald Assogba, Khuzaie, Usama, Caudwell, Valerie, Chatelet, Valerie, Crougneau, Valerie, De Precigout, Valerie, Drouillat, Valerie, Galantine, Valerie, Hugot, Valerie Granveau, Leroy, Valerie, Boubia, Veronique, Falque, Veronique, Fournier, Veronique, Queron, Veronique, Viviani, Veronique, Gueuttin, Victor, Panescu, Victor, Calonge, Victorio Menoyo, Nguyen, Viet, Allot, Vincent, Delattre, Vincent, Leduc, Vincent, Pradier, Vincent, Aglae, Violaine Emal, Badulescu, Viorica, Molina, Virginia, Besson, Virginie, Chaigne, Virginie, Jaber, Waddah, Boudi, Wael, El Haggan, Wael, Guillon, Wen Qin, Aneni, Wided Tabbi, Hanf, William, Kohn, Wladimir, Bellenfant, Xavier, Gaudry, Xavier Moreau, Delmas, Yahsou, Knefati, Yannick, Saingra, Yannick, Tirolien, Yannick, Mann, Youssef, Brunak, Yvan, Dimitrov, Yves, Doussy, Yves, Tanter, Yves, Benabid, Zaid, Soltani, Zaara, Boukerroucha, Zacharia, Takla, Zafer, Ramanantsialonina, Zana, Dickson, Zara, Tubail, Zead, Pour, Zoe Koochaki, Boukhalfa, Zohra, and Jacquot, Zohra

Abstract

The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed.

Published
2020
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9. Moving towards ambitious climate policies: Monetised health benefits from improved air quality could offset mitigation costs in Europe.

Author

Schucht, Simone, Colette, Augustin, Rao, Shilpa, Holland, Mike, Schöpp, Wolfgang, Kolp, Peter, Klimont, Zbigniew, Bessagnet, Bertrand, Szopa, Sophie, Vautard, Robert, Brignon, Jean-Marc, and Rouïl, Laurence

Subjects
CLIMATE change, ENVIRONMENTAL policy, HEALTH impact assessment, AIR quality, COST analysis
Abstract

Air quality and related health effects are not only affected by policies directly addressed at air pollution but also by other environmental strategies such as climate mitigation. This study addresses how different climate policy pathways indirectly bear upon air pollution in terms of improved human health in Europe. To this end, we put in perspective mitigation costs and monetised health benefits of reducing PM 2.5 (particles less than 2.5 μm in diameter) and ozone concentrations. Air quality in Europe and related health impacts were assessed using a comprehensive modelling chain, based on global and regional climate and chemistry-transport models together with a health impact assessment tool. This allows capturing both the impact of climate policy on emissions of air pollutants and the geophysical impact of climate change on air quality. Results are presented for projections at the 2050 horizon, for a set of consistent air pollution and climate policy scenarios, combined with population data from the UN's World Population Prospects, and are expressed in terms of morbidity and mortality impacts of PM 2.5 and ozone pollution and their monetised damage equivalent. The analysis shows that enforcement of current European air quality policies would effectively reduce health impacts from PM 2.5 in Europe even in the absence of climate policies (life years lost from the exposure to PM 2.5 decrease by 78% between 2005 and 2050 in the reference scenario), while impacts for ozone depend on the ambition level of international climate policies. A move towards stringent climate policies on a global scale, in addition to limiting global warming, creates co-benefits in terms of reduced health impacts (68% decrease in life years lost from the exposure to PM 2.5 and 85% decrease in premature deaths from ozone in 2050 in the mitigation scenario relative to the reference scenario) and air pollution cost savings (77%) in Europe. These co-benefits are found to offset at least 85% of the additional cost of climate policy in this region. [ABSTRACT FROM AUTHOR]

Published
2015
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12. Les « ichtyolites » (Actinopterygii) de la collection Jean-Baptiste Beurard (1745–1835) : intérêt historique et redécouverte de la série type d’Armigatus brevissimus(Blainville, 1818) du Cénomanien du Liban

Author

Brignon, Arnaud and Brignon, Arnaud

Abstract

Cet article souligne le rôle Jean-Baptiste Beurard dans l’histoire de la paléoichtyologie. Ancien chanoine de la cathédrale de Toul, il trouva après les affres des débuts de la Révolution un emploi d’agent du gouvernement attaché à l’administration des mines entre 1794 et 1815. Chargé de la surveillance des mines de mercure dans les nouveaux départements annexés par la France sur la rive gauche du Rhin, il redécouvrit en juillet 1799 le fameux gisement d’« ichtyolites» (poissons fossiles) imprégnés de cinabre de Münsterappel daté du Permien inférieur. Il envoya plusieurs spécimens dans des collections institutionnelles parisiennes. Des représentants de l’espèce Paramblypterus duvernoy(Agassiz, 1833) (Actinopterygii, Amblypteridae), probablement envoyés par Beurard avant 1809 d’après le témoignage de Barthélémy Faujas de Saint-Fond, ont été identifiés dans les collections du Muséum national d’Histoire Naturelle, Paris. Un autre spécimen ayant appartenu de manière incontestable à Beurard est conservé dans les collections Géosciences de Sorbonne Université et revêt un intérêt historique tout particulier. Beurard possédait également dans sa collection deux échantillons de poissons fossiles du Cénomanien de Haqel dans l’actuel Liban, qu’il avait reçu de son neveu Claude Charles Harmand (1784–1847), officier de marine, en 1817. À partir d’eux, Henri Marie Ducrotay de Blainville décrivit deux espèces qu’il nomma Clupea beurardiBlainville, 1818aet Clupea brevissimaBlainville, 1818a. La première n’est plus considérée comme valide et la seconde est aujourd’hui assignée au genre ArmigatusGrande, 1982(Actinopterygii, Clupeomorpha) dont elle est l’espèce type. Un de ces spécimens est conservé au Natural History Museum, Londres, et provient de la collection de William Willoughby Cole (1807–1886), comte d’Enniskillen, qui avait acquis une partie de la collection Beurard. Étiqueté par erreur Clupea beurardipar Beurard, cet échantillon porte en réalité les quatre syntypes d’Armigatus brevissimus. Un lectotype est désigné ici pour fixer le statut de cette espèce, certainement la plus abondante et la plus iconique du gisement de Haqel.

Published
2021
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13. Assessment of space radiation effects on solid-state Brillouin phase conjugate mirrors

Author

Brignon, A., Richard, S., Gusarov, A., Berghmans, F., Georges, M., Thibert, T., and Lien, Y.

Abstract

Optical phase conjugation (OPC) provides a means of dynamical correction of thermally induced aberrations in high-power laser systems. This method is particularly interesting for space applications because it is passive, mechanically simple, and allows for improved beam quality with only a small loss in power. To exploit it one has to assess the effect of the space environment, and in particular of space radiation, on the properties of the materials that are suitable for phase-conjugating mirrors (PCMs). We have investigated both materials providing OPC via stimulated Brillouin scattering and actual PCMs with regard to their radiation hardness. Proton- and gamma-irradiated PCMs in the form of 30-cm long silica rods and 5-cm long TeO_2 crystals were tested in a single frequency flash-lamp pumped Nd:YAG system delivering up to 220 mJ pulses with a 20 ns duration at a 50 Hz repetition rate. The difference in the reflectivity between irradiated and nonirradiated components was found to be within the measurement errors. Gamma irradiation of TeO_2 resulted in a decrease of the laser-induced damage threshold, while for silica possible changes were below the detection limit. Our results show that synthetic fused silica, and Lithosil in particular, can be used for generating the OPC in laser systems operating in a space radiation environment.

Published
2007

14. Influence de la teneur en cas?ine ? sur les caract?ristiques physico-chimiques et l'aptitude ? la coagulation enzymatique du lait de ch?vre

Author

Remeuf, Florent, Ricordeau, Guy, Brignon, Ghislaine, and Grosclaude, Fran?ois

Abstract

The influence of ?-casein content on physico-chemical and renneting properties of goat's milk. Milks from goats of A/A, A/O and O/O genotypes at the ?-casein locus were compared in terms of N fractions, micellar characteristics, Ca distribution and renneting properties. A/A milks were associated with higher casein and lower total calcium contents, lower pH, and larger and more hydrated and mineralized micelles than O/O milks. These showed a poor rennetability as compared with normal milks. These results were in good accordance with current micellar models, and with previous data on ?s1-casein genetic polymorphism. Les fractions prot?iques et calciques de trois types de laits caprins de g?notypes A/A, A/O et O/O pour la cas?ine ? ont ?t? analys?es. Les laits A/A sont caract?ris?s par des teneurs en cas?ine et en prot?ine plus ?lev?es, une concentration en calcium total et un pH plus bas, des micelles plus grosses, plus hydrat?es et moins min?ralis?es que les laits O/O. Les laits O/O pr?sentent une aptitude ? la coagulation enzymatique tr?s d?ficiente par rapport aux laits "normaux " . Ces r?sultats pr?sentent une bonne coh?rence avec les mod?les de structure micellaire actuellement admis, ainsi qu'avec les r?sultats d?j? acquis sur les effets du polymorphisme g?n?tique de la cas?ine ?s1.

Published
2001
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15. Influence de la teneur en caséine <formula notation="TeX">$\beta$</formula> sur les caractéristiques physico-chimiques et l'aptitude à la coagulation enzymatique du lait de chèvre

Author

Remeuf, Florent, Ricordeau, Guy, Brignon, Ghislaine, and Grosclaude, François

Abstract

The influence of $\beta$-casein content on physico-chemical and renneting properties of goat's milk. Milks from goats of A/A, A/O and O/O genotypes at the $\beta$-casein locus were compared in terms of N fractions, micellar characteristics, Ca distribution and renneting properties. A/A milks were associated with higher casein and lower total calcium contents, lower pH, and larger and more hydrated and mineralized micelles than O/O milks. These showed a poor rennetability as compared with normal milks. These results were in good accordance with current micellar models, and with previous data on $\alpha_{{\rm s1}}$-casein genetic polymorphism.

Published
2001

16. Two-dimensional gel analysis of the proteome of lager brewing yeasts

Author

Joubert, Richard, Brignon, Pierre, Lehmann, Christophe, Monribot, Christelle, Gendre, François, and Boucherie, Hélian

Abstract

Modern lager brewing yeasts used in beer production are hybrid strains consisting of at least two different genomes. To obtain information on the identity of the parental strains that gave rise to industrial lager yeasts, we used two-dimensional (2-D) gel electrophoresis and analysed the proteomes of different Saccharomyces species isolated from breweries. We found that the proteome of lager brewing yeasts and of the type strains of S. carlsbergensis, S. monacensis and S. pastorianus can be interpreted as the superimposition of two elementary patterns. One originates from proteins encoded by a S. cerevisiae-like genome. The other corresponds to a divergent Saccharomyces species whose best representative is a particular S. pastorianus strain, NRRL Y-1551. A map of industrial lager brewing yeasts has been established, with the individual origin of proteins and with identification of protein spots by comparison to known S. cerevisiae proteins. This 2-D map can be accessed on the Lager Brewing Yeast Protein Map server through the World Wide Web. This study provides the first example of the use of proteome analysis for investigating taxonomic relationships between divergent yeast species. Copyright © 2000 John Wiley & Sons, Ltd.

Published
2000

17. Premiers elements de structure primaire des caseines αs2bovines

Author

Brignon, Ghislaine, Dumas, Bruno Ribadeau, and Mercier, Jean-Claude

Abstract

The bovine αs2‐, αs3‐, αs4‐ and αs6‐caseins [1] were isolated. The 4 proteins had the same amino‐acid composition and C‐terminal sequence, but different phosphorus contents. From a mixture of these proteins (designated as ‘αs2‐complex’) and from αs3‐casein a single and identical N‐terminal sequence was obtained by Edman degradation. It seems therefore that the 4 proteins have the same peptide chain and only differ in their phosphorus content. For this reason we propose to modify the nomenclature of Annan and Manson [1] and to use in future the single term αs2to designate the caseins which have been previously called αs2, αs3, αs4and αs6by these authors. The study of the primary structure of the peptide chain, which has confirmed these results, was undertaken on the S‐carboxymethylated αs2‐complex. From a cyanogen bromide digest and from a tryptic hydrolyzate of the αs2‐complex, 5 and 25 peptides were obtained respectively, both sets of peptides accounting for the whole peptide chain. Examination of the tryptic peptides containing methionine combined with the N‐ and C‐terminal sequences of the αs2‐complex and some CNBr peptides, gave the order of the CNBr peptides, H.CN4CN2CN5CN1CN3.OH, which contain 4, 22, 115, 49 and 17 residues respectively. A partial sequence accounting for half of the peptide chain of the αs2‐complex is given. This peptide chain is likely composed of 207 amino‐acid residues

Published
1976
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19. Rhodium-doped barium titanate phase-conjugate mirror for an all-solid-state, high-repetition-rate, diode-pumped Nd:YAG master-oscillator power amplifier laser

Author

Brignon, Arnaud, Sénac, Stéphane, Ayral, Jean-Luc, and Huignard, Jean-Pierre

Abstract

Self-pumped phase conjugation in infrared-sensitive photorefractive rhodium-doped barium titanate (Rh:BaTiO_3) is investigated with a kilohertz-repetition-rate, diode-pumped Nd:YAG laser. We also demonstrate the operation of a diode-pumped Nd:YAG master-oscillator power-amplifier system with such a compact and solid-state phase-conjugate mirror for wave-front restoration. We obtain near-diffraction-limited output pulses of 20-mJ energy at a repetition rate of 200 Hz and a 1-min response time of the phase-conjugate mirror. The performances of the Rh:BaTiO_3 crystal are compared with those obtained with a conventional Brillouin mirror.

Published
1998

20. Preparation and amino acid sequence of human κ-casein

Author

Brignon, Ghislaine, Chtourou, Abdessatar, and Ribadeau-Dumas, Bruno

Abstract

Human κ-casein was prepared from whole casein by successive hydroxyapatite and thiol-Sepharose chromatographies. The primary structure of its 99-residue N-terminal fragment has been determined by sequencing peptides obtained by tryptic and chymotryptic digestions of the whole protein. This fragment overlaps the known sequence of the 65-residue C-terminal fragment. The 158-residue sequence of human κ-casein was compared to those of goat, ewe, cow and rat κ-caseins. Only 22% of the residues are identical in homologous positions. The rate of divergence of the 93-residue N-terminal segment (para-κ-casein) appears to be higher than that of the rest of the molecule.

Published
1985
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22. Spatial beam cleanup of a Nd:YAG laser operating at 1.06 µm with two-wave mixing in Rh:BaTiO_3

Author

Brignon, Arnaud, Huignard, Jean-Pierre, Garrett, Mark H., and Mnushkina, Irina

Abstract

Spatial beam cleanup of a distorted cw Nd:YAG laser operating at λ = 1.06 µm is demonstrated with two-wave mixing in an infrared-sensitive rhodium-doped barium titanate crystal. Because of the high coupling gain of our crystal, high efficiencies are achieved in agreement with the standard photorefractive model.

Published
1997

27. Nouvelles données historiques sur les premiers dinosaures trouvés en France

Author

Brignon, Arnaud and Brignon, Arnaud

Abstract

Cet article passe en revue les premières découvertes de dinosaures faites en France avant que le terme Dinosauria n’ait été introduit par Richard Owen en 1842. En mettant à part les premières découvertes du théropode Streptospondylus altdorfensisfaites au XVIIIesiècle par Charles Bacheley dans le Jurassique des Vaches Noires, les principaux résultats démontrés ici sont les suivants (par ordre chronologique) : 1) les premiers restes de dinosaures (dents de théropodes) du Calcaire de Caen (Bathonien) furent collectés par Arcisse de Caumont dans les carrières de Quilly en, ou avant, avril 1826 et la première mention de cette découverte fut publiée en 1827 ; 2) les restes de théropode que William Buckland avait observés en octobre 1826 dans le Cabinet d’Histoire naturelle de Besançon furent signalés dans une publication dès 1830 ; 3) la première mention à un dinosaure du Jurassique supérieur du Boulonnais fut longtemps considérée avoir été celle faite par Constant Prévost en 1839. Des dents d’un théropode et d’un dinosaure herbivore furent, semble-t-il, découvertes dans ces formations par Eugène Robert en automne 1833. Une autre dent de théropode, celle-ci identifiable de manière incontestable, fut collectée en, ou avant, juillet 1835 par Bruno Marmin comme en atteste une lettre inédite à Jules Desnoyers ; 4) Le genre PoekilopleuronEudes-Deslongchamps, 1836 et son espèce type P. bucklandiiEudes-Deslongchamps, 1836, du Calcaire de Caen (Bathonien moyen), ont été créés de manière valide en 1836 ; 5) l’humérus de sauropode découvert dans le Crétacé supérieur de la plaine de Lisle près de Périgueux et figuré par Paul Gervais en 1852 fut donné au Muséum d’Histoire naturelle à Paris par un certain Simon Bornet en 1841 ; 6) l’humérus de sauropode du grès vert (Albien) de Bédoin près du mont Ventoux, décrit par Gervais en 1852 sous le nom d’Aepisaurus elephantinus, fut découvert par Prosper Renaux en 1841. Ce dernier effectua des dessins du spécimen à partir desquels une lithographie restée inédite fut réalisée. Renaux est ainsi le premier à avoir découvert et étudié un dinosaure, authentifié de manière incontestable, dans le Crétacé provençal. Les affinités de cet os avec les genres Megalosauruset Iguanodonfurent reconnues par Henri Marie Ducrotay de Blainville dès 1842.

Published
2018
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34. CKD and Its Risk Factors among Patients with Cystinuria.

Author

Prot-Bertoye C, Lebbah S, Daudon M, Tostivint I, Bataille P, Bridoux F, Brignon P, Choquenet C, Cochat P, Combe C, Conort P, Decramer S, Doré B, Dussol B, Essig M, Gaunez N, Joly D, Le Toquin-Bernard S, Méjean A, Meria P, Morin D, N'Guyen HV, Noël C, Normand M, Pietak M, Ronco P, Saussine C, Tsimaratos M, Friedlander G, Traxer O, Knebelmann B, and Courbebaisse M

Subjects
Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Child, Child, Preschool, Comorbidity, Cystinuria diagnosis, Cystinuria therapy, Delayed Diagnosis, Female, France epidemiology, Glomerular Filtration Rate, Humans, Infant, Male, Middle Aged, Nephrectomy, Prevalence, Renal Insufficiency, Chronic pathology, Renal Insufficiency, Chronic physiopathology, Retrospective Studies, Risk Factors, Sex Factors, Young Adult, Cystinuria epidemiology, Hypertension epidemiology, Renal Insufficiency, Chronic epidemiology
Abstract

Background and Objectives: Cystinuria is an autosomal recessive disorder affecting renal cystine reabsorption; it causes 1% and 8% of stones in adults and children, respectively. This study aimed to determine epidemiologic and clinical characteristics as well as comorbidities among cystinuric patients, focusing on CKD and high BP., Design, Setting, Participants, & Measurements: This retrospective study was conducted in France, and involved 47 adult and pediatric nephrology and urology centers from April 2010 to January 2012. Data were collected from 442 cystinuric patients., Results: Median age at onset of symptoms was 16.7 (minimum to maximum, 0.3-72.1) years and median diagnosis delay was 1.3 (0-45.7) years. Urinary alkalinization and cystine-binding thiol were prescribed for 88.8% and 52.2% of patients, respectively, and 81.8% had at least one urological procedure. Five patients (1.1%, n=4 men) had to be treated by dialysis at a median age of 35.0 years (11.8-70.7). Among the 314 patients aged ≥16 years, using the last available plasma creatinine, 22.5% had an eGFR≥90 ml/min per 1.73 m(2) (calculated by the Modification of Diet in Renal Disease equation), whereas 50.6%, 15.6%, 7.6%, 2.9%, and 0.6% had an eGFR of 60-89, 45-59, 30-44, 15-29, and <15, respectively. Among these 314 patients, 28.6% had high BP. In multivariate analysis, CKD was associated with age (odds ratio, 1.05 [95% confidence interval, 1.03 to 1.07]; P<0.001), hypertension (3.30 [1.54 to 7.10]; P=0.002), and severe damage of renal parenchyma defined as a past history of partial or total nephrectomy, a solitary congenital kidney, or at least one kidney with a size <10 cm in patients aged ≥16 years (4.39 [2.00 to 9.62]; P<0.001), whereas hypertension was associated with age (1.06 [1.04 to 1.08]; P<0.001), male sex (2.3 [1.3 to 4.1]; P=0.003), and an eGFR<60 ml/min per 1.73 m(2) (2.7 [1.5 to 5.1]; P=0.001)., Conclusions: CKD and high BP occur frequently in patients with cystinuria and should be routinely screened., (Copyright © 2015 by the American Society of Nephrology.)

Published
2015
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35. Direct detection of viable bacteria, molds, and yeasts by reverse transcriptase PCR in contaminated milk samples after heat treatment.

Author

Vaitilingom M, Gendre F, and Brignon P

Subjects
Animals, Hot Temperature, Peptide Elongation Factor Tu genetics, Bacteria isolation & purification, Fungi isolation & purification, Milk microbiology, Polymerase Chain Reaction, Yeasts isolation & purification
Abstract

A fast, sensitive, and target contaminant-modulable method was developed to detect viable bacteria, molds, and yeasts after heat treatment. By reverse transcriptase PCR with elongation factor gene (EF-Tu or EF-1 alpha)-specific primers, the detection level was 10 cells ml of milk-1. The simplicity and rapidity (4 h) of the procedure suggests that this method may be easily transposable to other foods and other contaminants.

Published
1998
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36. Identification of cis-elements regulating the expression of an Arabidopsis histone H4 gene.

Author

Chaubet N, Flénet M, Clément B, Brignon P, and Gigot C

Subjects
Base Sequence, DNA Footprinting, Genes, Reporter, Glucuronidase analysis, Glucuronidase genetics, Meristem, Molecular Sequence Data, Mutation, Plants, Genetically Modified, RNA, Messenger biosynthesis, RNA, Plant, Recombinant Fusion Proteins analysis, Recombinant Fusion Proteins biosynthesis, Arabidopsis genetics, Gene Expression Regulation, Plant genetics, Histones genetics, Promoter Regions, Genetic genetics
Abstract

Protein-DNA interactions in the proximal region of an Arabidopsis H4 histone gene promoter were analyzed by DMS in vivo footprinting combined with LMPCR amplification. Interactions were identified over six particular sequence motifs, five of which were previously shown to bind proteins in maize histone H3 and H4 promoters and are commonly found in the corresponding regions of other plant histone gene promoters. These motifs are located within a 126 bp fragment which was previously shown to confer preferential expression in meristems of transgenic plants. The contribution of each cis-element to the overall expression level and specificity was investigated by testing individual or combined mutations in transgenic Arabidopsis plants. All five motifs behaved as positive cis-elements of unequal strength. The GCCAAT-like sequence GCCACT behaved as a strong positive cis-element but had no influence on the specificity. In contrast, the nonamer AGATCGACG and to a lesser extent the closely linked hexamer CCGTCG proved to be essential for meristem-specific expression. Involvement of the highly conserved histone-specific octamer CGCGGATC in specific expression was revealed at some stages of meristem development. Importance of these three cis-elements, nonamer, hexamer, and octamer, was further confirmed by the fact that combining mutations of two of them either abolished the promoter activity or completely modified the promoter specificity. Mutation of the fifth cis-element, a degenerate copy of the octamer, little perturbed the promoter function. However disruption of both octamers had a dramatic negative effect, thus suggesting that the two copies cooperate to achieve maximal function in the wild-type promoter, possibly by mobilizing the proliferation-specific factors binding to the nonamer and CCGTCG cis-elements.

Published
1996
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37. Constitutive and cell-division-inducible protein-DNA interactions in two maize histone gene promoters.

Author

Brignon P and Chaubet N

Subjects
Base Sequence, Cell Division genetics, DNA genetics, DNA Fingerprinting, Deoxyribonuclease I, Gene Expression, Molecular Sequence Data, Multigene Family, Sulfuric Acid Esters, Zea mays cytology, Genes, Plant, Histones genetics, Promoter Regions, Genetic, Zea mays genetics
Abstract

Protein-DNA interactions in the promoter regions of two maize histone genes have been analyzed by DNase I and DMS in vivo footprinting combined with LMPCR amplification. Both promoters present a bimodular structure characterized by a proximal cell division-specific set of interactions and a distal region which displays constitutive footprints but enhancement of these footprints upon cell proliferation. The inducible region contains two cis-elements common to all replication-dependent plant histone genes, one of them having previously been shown to be a target for the wheat nuclear protein HBP-2. In the constitutive region, the first demonstration for the existence of a transcription factor binding to the highly conserved plant histone-specific octamer CGCGGATC is provided. Exchange of cell-type-specific factors is postulated to occur at that site. Additional immediate upstream constitutive elements binding regulatory proteins include a degenerate octameric sequence, a CCAAT-box, a CACCC sequence and composite ACGTCA/ACGTGG hexameric sequences binding HBP-1-related trans-acting factors. The close proximity of these elements within the constitutive region and the redundancy of some of them suggest complex cooperation and competition mechanisms contributing to achieve the final expression level and likely also to mediate the interplay between constitutive and inducible factors.

Published
1993
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